Espa Lipon (600 mg

Malinga ndi malangizo a Espa-Lipon, mankhwalawa ali ndi detoxization, hypoglycemic, hypocholesterolemic ndi hepatoprotective, potenga nawo gawo la metabolism. Thioctic acid, yomwe ndi gawo la Espa-Lipon, imaphatikizidwa ndi oxidative reaction ya alpha-keto acids ndi pyruvic acid, imayendetsa ntchito ya chiwindi, komanso imathandizira kagayidwe ka cholesterol.

Mwa chikhalidwe chake, thioctic acid ndi ofanana ndi mavitamini a gulu B. Espa-Lipon amathandizira kukulitsa glycogen m'maselo a chiwindi, amachepetsa kuchuluka kwa shuga m'magazi, ndikuthana ndi kuphwanyidwa kwa chiwopsezo cha maselo pakuchitika kwa insulin. Mankhwalawa amathandizira kuthetsa poizoni m'thupi, amateteza maselo a chiwindi kuti asatchulidwe ndi zinthu zoopsa, amateteza thupi poizoni ndi mchere wazitsulo zolemera.

Mphamvu ya neuroprotective ya Espa-Lipon ndikuletsa lipid peroxidation m'mitsempha yamanjenje, kuyambitsa kutsika kwa magazi kwa endoneural, ndikuwongolera njira yoyendetsera kukhudzidwa kwa mitsempha kudzera m'maselo.

Kumwa mankhwalawa odwala omwe ali ndi motor neuropathy, malinga ndi ndemanga ya Espa-Lipon, kumayambitsa kuwoneka kwa ma macroergic ambiri m'misempha.

Mukamamwa pakamwa, Espa-Lipon amakhala bwino ndipo amatengeka mosavuta m'mimba, ndipo kugwiritsa ntchito mankhwalawa pamodzi ndi chakudya kumachepetsa kuthamanga ndi mtundu wa kuyamwa kwa mankhwalawo.

Kupanga kwa thioctic acid kumachitika ndi conjugation ndi oxidation a mbali zam'mbali. The yogwira mankhwala Espa-Lipon amuchotsa mu mkodzo mu mawonekedwe a metabolites. Hafu ya moyo wa mankhwala a m'madzi am'magazi ndi 10-20 mphindi.

Espa-Lipon imakhala ndi "woyamba kupitilira" kudzera mu chiwindi - ndiye kuti, mphamvu zomwe zimagwiritsidwa ntchito ndi mankhwalawa zimachepetsedwa mothandizidwa ndioteteza zachilengedwe kuchokera kuzinthu zakunja kulowa thupi.

Mlingo

Tsatirani njira yothetsera kulowetsedwa 600 mg / 24 ml

24 ml ndi 1 ml ya mankhwala omwe ali

ntchito yogwira: thioctic acid mu 24 ml-600.0 mg ndi 1 ml-25.0 mg

muwothandiziraszinthua: ethylenediamine, madzi a jakisoni.

Transparent amadzimadzi kuwala kuwala chikasu chikasu chikasu.

Mankhwala

Pharmacokinetics

Zogulitsa. Ndi makonzedwe amtsempha, nthawi yofika ndende yozama ya plasma ndi mphindi 10-11, kupezeka kwa ndende 25 25 μg / ml, dera lomwe lili pansi pa nthawi yokhazikika ndi pafupifupi 5 μg h / ml. Bioavailability ndi 100%.

Kupenda: Thioctic acid imadutsa "yoyamba kudutsa" kudzera mu chiwindi.

Kugawa: kuchuluka kwa magawidwe ndi pafupifupi 450 ml / kg.

Kuchotsa: thioctic acid ndi metabolites ake amuchotsa impso (80-90%). Kutha kwa theka-moyo ndi mphindi 20-50. Chilolezo chonse cha plasma ndi mphindi 10-15.

Mankhwala

Espa-lipon - mankhwala am'mbuyomu antioxidant (amamanga ma radicals aulere), amapangidwa m'thupi ndi oxidative decarboxylation wa alpha-keto acid. Monga coenzyme ya mitochondrial multienzyme complexes, imatenga nawo oxidative decarboxylation wa pyruvic acid ndi alpha-keto acid. Zimathandizira kuchepetsa kuchuluka kwa shuga m'magazi ndikuwonjezera glycogen m'chiwindi, komanso kuthana ndi insulin. Mwa chikhalidwe cha zochita zamapangidwe azachilengedwe, zimakhala pafupi ndi mavitamini a B. Zimatenga nawo gawo pazolemba za lipid ndi carbohydrate metabolism, zimathandizira kagayidwe ka cholesterol, zimapangitsa chiwindi kugwira ntchito, zimachepetsa kuwonongeka kwa pooin ndi exo native poizoni. Amakweza ma neuroni a trophic.

Mankhwala

Thioctic acid — antioxidant, yomwe imapangidwa mthupi ndi decarboxylation ya alpha-keto acid. Ili ndi mphamvu yofanana Mavitamini B. Imagwira gawo la metabolism yamphamvu, imayendetsa lipid (cholesterol metabolism) ndi metabolism ya carbohydrate. Ogulitsa lipotropicndi kutulutsa mphamvu. Zotsatira zama kagayidwe kazakudya zimayambitsa kuwonjezeka glycogenmu chiwindi ndikuchepa shugam'magazi.

Imakonza trophism ya neurons, chifukwa imadziunjikira mkati ndikuchepetsa zomwe zili mwaulere ndi ma chiwindi ntchito (ndi njira yamankhwala).

Ogulitsa lipid-kutsitsa, hypoglycemic, hepatoprotectivendi Hypocholesterolemic kwenikweni.

Mlingo ndi makonzedwe

Kumayambiriro kwa mankhwalawa, mankhwalawa amaperekedwa kwa kholo. Pambuyo pake, pochita mankhwala othandizira kukonza, amasintha kumwa mankhwalawo mkati.

Tsatirani njira yothetsera kulowetsedwa:

Mankhwala chikuyendetsedwera m`nsinga mu mawonekedwe a infusions pambuyo koyambirira dilution mu 200-250 ml ya isotonic sodium kolorayidi njira.

At mitundu yayikulu ya matenda ashuga polyneuropathy The mankhwala kutumikiridwa kamodzi patsiku mu mtsempha wa 24 ml ya mankhwala mu isotonic sodium mankhwala enaake (omwe amafanana ndi 600 mg wa thioctic acid patsiku). Kutalika kwa kulowetsedwa ndi mphindi 30. Kutalika kwa kulowetsedwa ndi masiku 5-28.

Makonzedwe okonzedwa okonzedwa amayenera kusungidwa m'malo amdima ndikugwiritsa ntchito maola 6 mutatha kukonzekera. Pa kulowetsedwa ayenera kukulunga botolo ndi pepala lakuda. Chotsatira, muyenera kusinthira ku mankhwalawa pokonzanso mapiritsi a 400-600 mg patsiku. Kutalika kochepa kwambiri kwa mapiritsi ndi miyezi itatu.

Nthawi zina, kumwa mankhwalawa kumakhudzanso kugwiritsa ntchito nthawi yayitali, nthawi yomwe madokotala amayenera kudziwa.

Zotsatira zoyipa

- totupa pakhungu, urticaria, kuyabwa

- zokhudza zonse zoyipa (anaphylactic mantha)

kusanza, kusanza

- Amataya magazi, amakonda kutuluka magazi

kuperewera kwa zinthu za m'mwazi

- Kulimbitsa shuga (chifukwa cha kuchuluka kwa glucose), kumatha kutsatana ndi chizungulire, kuwonongeka kosiyanasiyana kwa mawonekedwe, kutuluka thukuta kwambiri

- kupweteka kwa mutu (kudutsa mosazungulira), kuchuluka kwazovuta zamkati, kupuma kwamatenda (pambuyo pakuwongolera mwachangu)

Zochita zamankhwala osokoneza bongo

Pogwiritsa ntchito munthawi yomweyo Espa-Lipon wokhala ndi insulin komanso pakamwa antidiabetesic othandizira, zotsatira za hypoglycemic zotsalazo zimatheka.

Thioctic acid imapanga zovuta zovuta zosungunuka ndi mamolekyulu a shuga (mwachitsanzo, yankho la levulose).

Njira yothetsera imakhala yosagwirizana ndi yankho la glucose, yankho la Ringer, komanso ndi mayankho omwe amatha kuyanjana ndi magulu a SH-magulu kapena mabuluni osokoneza.

Thioctic acid (monga njira yothetsera kulowetsedwa) amachepetsa mphamvu ya cisplatin.

Ndi munthawi yomweyo, chithandizo cha chitsulo, magnesium, mkaka wokhala ndi mkaka sichikulimbikitsidwa.

Malangizo apadera

Mukamachita mankhwala a Espa-Lipon odwala omwe ali ndi matenda a shuga, makamaka kumayambiriro kwa chithandizo, kuwunikira pafupipafupi (malinga ndi malingaliro a dokotala) kuyang'anira kuchuluka kwa shuga m'magazi. Nthawi zina, kuchepetsa mankhwala a hypoglycemic wothandizira amafunikira.

Pa chithandizo, ndikofunikira kukana kumwa mowa, chifukwa achire a thioctic acid amakhala ofooka.

Njira yothetsera kulowetsedwa imayendetsedwa kudzera m'mitsempha, mwachitsanzo, mkati mwa masabata 2-4 koyambirira kwa chithandizo.

Mwa kuyamwa kwamitsempha, zomwe zili mu Espa-Lipon 600 mg ampoule zimasungunuka ndi 250 ml ya 0,9% sodium kolorayidi, munjira yophika kwakanthawi osachepera mphindi 30.

Chifukwa cha kuchuluka kwa zinthu zomwe zimagwira, njira y kulowetsedwa iyenera kukonzedwa musanayendetse, ma ampoules ayenera kuchotsedwa pokhapira pokhapokha asanagwiritse ntchito, vial iyenera kukulungidwa ndi pepala lakuda panthawi ya kulowetsedwa. Alumali moyo wa yankho lomwe lakonzedwa kuti mugwiritse ntchito pambuyo povunditsidwa ndi isotonic sodium chloride solution ndi wokwanira maola 6 mukasungidwa m'malo amdima.

Mimba komanso kuyamwa

Chifukwa chochepa ndi kugwiritsa ntchito mankhwalawa, Espa-Lipon sanalembedwe amayi apakati.

Iwo ali osavomerezeka kugwiritsa ntchito mankhwalawa pa mkaka wa m'mawere, popeza palibe chidziwitso chambiri pakuchitika kwa mankhwala ndi mkaka wa m'mawere.

Zotsatira pa kuthekera koyendetsa galimoto kapena makina owopsa

Popeza mungakhale ndi zovuta zoyipa (zopweteka, diplopia, chizungulire), chisamaliro chikuyenera kuthandizidwa poyendetsa galimoto kapena pogwira ntchito ndi makina osunthira

Bongo

Zizindikiro mutu, nseru, kusanza.

Mankhwala osokoneza bongo amatha kuonetsa kuledzera kwamankhwala ndikusintha kwapakati pa dongosolo lamkati (psychomotor mukubwadamuka ndi kusokonezeka kwakukulu), lactic acidosis, hypoglycemia, ndi kukula kwa DIC.

Chithandizo: symptomatic mankhwala, ngati n`koyenera - anticonvulsant mankhwala, amayesa kukhalabe ntchito ziwalo zofunika. Palibe mankhwala enieni.

Wogwirizira Sitifiketi Yoyang'anira

Esparma GmbH, Seepark 7, 39116 Magdeburg, Germany

Adilesi ya bungwe yomwe imavomereza zomwe ogula akufuna pa mtundu wa zinthu ku Republic of Kazakhstan

Oimira ofesi ya Pharma Garant GmbH

Zhibek Zholy 64, off.305 Almaty, Kazakhstan, 050002

Zisonyezero zogwiritsira ntchito Espa-Lipona

Malinga ndi malangizowo, Espa-Lipon amawonetsedwa pazotsatira zotsatirazi za odwala:

• Polyneuropathies (kuphatikizapo matenda ashuga ndi zidakwa),
• Matenda a chiwindi (kuphatikizapo matenda amitsempha ya m'mimba ndi matenda otupa chiwindi (hepatitis),
• Mankhwala osokoneza bongo kapena oopsa omwe amaphatikizidwa ndi poyizoni omwe ali ndi mchere wazitsulo zolemera, bowa, etc.

Komanso, mankhwalawa amagwira ntchito motsutsana ndi matenda a atherosulinosis, omwe amagwiritsidwa ntchito pochizira komanso kupewa matenda osokoneza bongo.

Contraindication

Espa-Lipon sinafotokozeredwe odwala omwe amadwala matendawa chifukwa cha kudwala kwambiri, glucose-galactose malabsorption syndrome, komanso anthu omwe ali ndi vuto lactase m'thupi.

Mosamala, kugwiritsa ntchito Espa-Lipon ndikulimbikitsidwa kwa odwala omwe ali ndi matenda osokoneza bongo - ndi kuvomerezedwa kwa kusintha kwa mankhwala a hypoglycemic othandizira. Ana sayenera kulandira chithandizo cha Espa-Lipon kwa ana ochepera zaka 18 - chifukwa cha kusowa kwa chidziwitso pakugwiritsa ntchito mankhwalawa m'gulu la odwala. Ngati pali zisonyezo zofunika, mankhwalawa atha kutumizidwa ndi anthu amsinkhu uwu molingana ndi malingaliro a dokotala, poganizira mlingo wa wodwalayo.

Chitetezo chonse cha Espa-Lipon cha thanzi la mwana wosabadwa mukamamwa mankhwalawa sichinatsimikizidwenso. Ngati kuli koyenera kuthandiza mayi yemwe ali ndi Espa-Lipon panthawi yachilendo, ndikofunikira kuthetsa vuto lakumayamwitsa mwana kuyambira bere.

Kuyanjana kwa mankhwala osokoneza bongo

The munthawi yomweyo mankhwala a Espa-Lipon ndi m`kamwa hypoglycemic mankhwala ndi insulin akhoza kuyambitsa kuwonjezeka kwa hypoglycemic zotsatira - kuwonjezeka kuzindikira kwa zotumphukira zimakhala za thupi insulin.

Kugwiritsidwa ntchito kwa Espa-Lipon malinga ndi malangizo pamodzi ndi ethyl mowa kumachepetsa ntchito ya thioctic acid. Munthawi ya chithandizo ndi mankhwalawa, tikulimbikitsidwa kuti musamamwe mankhwala okhala ndi Mowa ndi zakumwa zoledzeretsa.

Kuphatikiza apo, ntchito ya thioctic acid yokhudzana ndi kumangika kwazitsulo idapezeka, chifukwa chake, kugwiritsa ntchito Espa-Lipon nthawi imodzi ndi mankhwala okhala ndi chitsulo, calcium, ion ya magnesium imatheka ndikutenga kwa maola awiri pakati pamiyeso ya mankhwala.

Kutenga Espa-Lipon ndi chisplatin kumachepetsa mphamvu ya mankhwalawa.

Espa-Lipon, malangizo ogwiritsira ntchito (Njira ndi Mlingo)

Nthawi zambiri, chithandizo chimayamba ndi infusions wa iv, kenako ndikusinthana ndi mapiritsi a Espa-Lipon. Mapiritsi amatengedwa pakamwa, popanda kutafuna, mphindi 30 musanadye 1 nthawi patsiku. Tsiku mlingo wa 600 mg. 3 miyezi Monga adanenera dokotala, mankhwalawa amatha kumwa kwa nthawi yayitali.

At matenda ashuga ulamuliro wofunikira shugam'magazi. Pa chithandizo, kugwiritsa ntchito sikutsalira za mowazomwe zimafotokoza mphamvu ya mankhwalawo.

Kuchita

Kukula kwa zotsatira za hypoglycemic kumadziwika mukagwiritsidwa ntchito ndi insulin kapena mankhwala amkamwa a hypoglycemic.

Kuchepetsa mphamvu Cisplatin pochita ndi thioctic acid.

EthanoliImafooketsa mphamvu ya mankhwalawa.

Imawonjezera odana ndi yotupa GKS.

Zomangira zitsulo, chifukwa chake kukonzekera kwachitsulo sangathe kupatsidwa nthawi yomweyo. Kulandila kwa mankhwalawa kumagawidwa munthawi (2 maola).

Ndemanga ya Espa Lipon

Palibe ndemanga zambiri pakugwiritsa ntchito mankhwalawa, chifukwa Espa-Lipon sanali kugwiritsidwa ntchito ngati monotherapy. Nthawi zambiri pamakhala kuwerengera za kugwiritsidwa ntchito kwake matenda ashuga polyneuropathy. Odwala anazindikira kuti phwando lalitali lidathandizira kuchotsa ululu m'miyendo ndi kumapazi, moto woyaka, "zikwapu", kukokana kwa minofu ndikubwezeretsa chidwi champhamvu.

At mafuta a chiwindi matenda a shuga mankhwalawa adathandizira kubisalira kwa bile ndulu komanso kuthetseratu zizindikiro za dyspeptic. Kupititsa patsogolo kwa odwala kunatsimikiziridwa ndi kusanthula (kusintha kwa ntchito) transaminase) ndi zoyeserera zabwino za zizindikiro za ultrasound.

Pali umboni pamene Espa-Lipon adagwiritsidwa ntchito bwino mu zovuta mankhwala atherosulinosis.

Muzochitika zonse, chithandizo chinayamba ndi madontho (10-20 otsitsa) kuchipatala, kenako odwala amatenga mawonekedwe a piritsi, nthawi zina mlingo wa tsiku ndi tsiku anali 1800 mg (mapiritsi atatu).

Zotsatira zoyipa, mseru ndi kutentha pa mtima zimadziwika mukamamwa mapiritsi komanso thrombophlebitis ndi mtsempha wamitseko.

Dzinalo:

Espa-Lipon (yankho la jakisoni) (Espa-Lipon)

Mndandanda umodzi wa Espa-Lipon 300 uli ndi:
Ethylene bisatsan-salt wa alpha lipoic acid (malinga ndi alpha lipoic acid) - 300 mg,
Zothira: madzi a jakisoni.

Mndandanda umodzi wa Espa-Lipon 600 uli ndi:
Ethylene bisatsan-salt wa alpha lipoic acid (malinga ndi alpha lipoic acid) - 600 mg,
Zothira: madzi a jakisoni.

Mimba

Pakadali pano, palibe deta yodalirika yokhudza kugwiritsa ntchito mankhwalawa Espa-Lipon panthawi yapakati. Mankhwalawa amatha kuikidwa pa nthawi yoyembekezera ndi dotolo wokhazikika ngati phindu lomwe mayi angayembekezere lingathe kupitilira zovuta zomwe zingakhalepo kwa mwana wosabadwayo.
Ngati ndi kotheka kugwiritsa ntchito mankhwalawa panthawi yoyamwitsa, ndikofunikira kuti mufunsane ndi dokotala kuti mupeze kusokonezeka kwa kuyamwitsa.

Malo osungira

Mankhwala tikulimbikitsidwa kuti tisungidwe m'malo owuma kutali ndi dzuwa mwachindunji pa 15 mpaka 25 digiri Celsius. Alpha lipoic acid imakhala ndi zithunzi zochulukirapo, kotero ma ampoule ayenera kuchotsedwa m'bokosi nthawi yomweyo asanagwiritse ntchito.
Alumali moyo wa mankhwala ndi zaka 3.
Yankho lokonzekera kulowetsedwa lithe kusungidwa m'malo amdima osaposa maola 6.