Insulin Humalog: momwe mungagwiritsire ntchito, kuchuluka kwake ndizovomerezeka komanso mtengo wake

Humalog® QuickPentTM jakisoni 100 IU / ml, 3 ml

1 ml yankho lili

ntchito yogwira - insulin lispro 100 IU (3.5 mg),

obwera: metacresol, glycerin, zinc oxide (malinga ndi Zn ++), sodium hydrogen phosphate, hydrochloric acid 10% kusintha pH, sodium hydroxide 10% yothetsera kusintha pH, madzi a jakisoni.

Chomveka chopanda utoto

Mankhwala

Pharmacokinetics

The pharmacokinetics ya lyspro insulin imawonetsedwa ndi kuyamwa mwachangu ndi kukwera m'magazi pambuyo pa 30 - 70 Mphindi atatha kubaya jekeseni.

Kutalika kwa nthawi ya insulin lispro kumatha kukhala kosiyanasiyana mwa odwala kapena nthawi zosiyanasiyana wodwala yemweyo ndipo zimatengera mlingo, malo a jakisoni, magazi, kutentha kwa thupi ndi zochitika zolimbitsa thupi.

Insulin ikalowetsedwa, lyspro imawonetsa kuyamwa mwachangu poyerekeza ndi insulin yaumunthu mwa odwala omwe ali ndi impso ndi hepatic, komanso kuchotsedwa kwachangu kwa odwala omwe ali ndi hepatic insufficiency. Odwala omwe ali ndi mtundu wachiwiri wa matenda osokoneza bongo omwe ali ndi vuto laimpso losiyanasiyana, kusiyana kwa pharmacokinetic pakati pa lyspro insulin ndi insulin yocheperako nthawi zambiri kumakhala kulimba ndipo samadalira kuwonongeka kwa aimpso.

Kuyankha kwa glucodynamic ku lyspro insulin sikudalira kugwira ntchito kwa chiwindi ndi impso.

Lyspro insulin yawonetsedwa kuti imakhala yofanana ndi insulin yaumunthu, koma zochita zake zimachitika mwachangu ndipo zimatha kwakanthawi.

Mankhwala

Lyspro insulin ndi analogue ya DNA yomwe imapanganso insulin ya anthu. Amasiyana ndi insulin yaumunthu mu kusintha kwa amino acid m'malo 28 ndi 29 a insulin B.

Chochita chachikulu cha insulin lyspro ndi malamulo a kagayidwe ka glucose. Kuphatikiza apo, imakhala ndi anabolic komanso anti-catabolic zotsatira zosiyanasiyana zamthupi. Mu minofu ya minofu, pali kuchuluka kwa glycogen, mafuta acid, glycerol, kuchuluka kwa mapuloteni komanso kuwonjezereka kwa kumwa ma amino acid, koma nthawi yomweyo kumachepa mu glycogenolysis, gluconeogeneis, ketogeneis, lipolysis, proteinabolism ndi kutulutsidwa kwa ma amino acid.

Mbiri ya pharmacodynamic ya insulin lyspro mwa ana ndiofanana ndi akulu.

Mlingo ndi makonzedwe

Mlingo wa Humalog® umatsimikiziridwa ndi dokotala payekha, kutengera zosowa za wodwala.

Humalog® imatha kutumikiridwa musanadye chakudya, ngati kuli kotheka mukatha kudya. Humalog® iyenera kutumikiridwa ngati jakisoni wofikira. Ngati ndi kotheka (mwachitsanzo, kuwongolera kuchuluka kwa glucose m'magazi panthawi ya ketoacidosis, matenda owopsa, nthawi ya postoperative kapena nthawi pakati pa opaleshoni) Humalog® imatha kutumikiridwa kudzera m'mitsempha.

Jakisoni wotsekemera amayenera kuperekedwa kwa mapewa, m'chiuno, matako kapena pamimba. Masamba a jakisoni ayenera kusinthidwa kuti malo omwewo sawagwiritsidwa ntchito nthawi zambiri kuposa kamodzi pamwezi.

Ndi makina amakono a Humalog®, chisamaliro chimayenera kutengedwa kuti musalowe mumtsempha wamagazi pakubaya. Pambuyo pa jakisoni, tsamba la jakisidwe siliyenera kutenthedwa. Odwala ayenera kuphunzitsidwa njira yolondola ya jakisoni.

Humalog® imadziwika ndi kuyamba mwachangu komanso nthawi yofupika yotalikira (maola 2-5) ndi makina oyenda poyerekeza ndi insulin wamba yamunthu. Kuyamba mwachangu kumakupatsani mwayi woperekera mankhwala musanadye. Kutalika kwa zochita za insulin iliyonse kumasiyana mosiyanasiyana mwa anthu osiyanasiyana komanso nthawi zosiyanasiyana mwa munthu m'modzi. Kuyamba mwachangu kwa mankhwalawa, poyerekeza ndi insulin yaumunthu, imasungidwa mosasamala malo omwe jakisoniyo anali. Kutalika kwa zochitika za Humalog® zimatengera mlingo, malo a jakisoni, magazi, kutentha ndi zochitika zolimbitsa thupi kwa wodwalayo.

Potsatira lingaliro la adotolo, Humalog® mu mawonekedwe a jekeseni wa subcutaneous amatha kuyikidwa limodzi ndi insulin kapena zotumphukira za sulfonylurea.

Kukonzekera mawu oyamba

Njira yothetsera mankhwalawa iyenera kukhala yowoneka bwino komanso yopanda utoto. Njira yothira ngati yafinya, kapena yakuwala pang'ono,

Kugwiritsa zolembera Zisanachitike

Musanapereke insulin, muyenera kuwerengera mosamala ma InstPions a QuickPen ™ Syringe pen. Pogwiritsa ntchito cholembera cha syringe cha QuickPenTM, ndikofunikira kutsatira zomwe zaperekedwa mu bukulo.

Sankhani tsamba la jakisoni.

Konzani khungu lanu jakisoni monga momwe dokotala wanenera.

Chotsani kapu yakunja yoteteza ku singano.

Konzani khungu pakuliphatikiza khola lalikulu.

Ikani singano mobisalira mu khola lomwe mwasonkhanitsa ndikuchita jekeseni mogwirizana ndi malangizo ogwiritsa ntchito cholembera.

Chotsani singano ndikufinya pang'onopang'ono malo a jakisoni ndi swab ya thonje kwa masekondi angapo. Osatupa malo a jakisoni.

Pogwiritsa ntchito singano yoteteza kunja, inthanitsani singano ndikuitaya.

Ikani chipewa pa cholembera.

Ndikofunikira kusinthana mawebusayiti enanso kuti tsamba lomwelo lisagwiritsidwe ntchito koposa kamodzi pamwezi.

Ma cholembera omwe amagwiritsidwa ntchito, mankhwala osagwiritsidwa ntchito, singano, ndi zogwiritsa ntchito ziyenera kutayidwa malinga ndi zofunikira zakomweko.

QuickPen ™ Syringe chole Guide

Mukamagwiritsa ntchito QUICKPEN ™ SYRINGE HANDLES, PESANI werengani izi zofunika.

Mawu Oyamba

QuickPen ™ Syringe chole ndi yosavuta kugwiritsa ntchito. Ndi chida chothandizira kuperekera insulini ("insulin cholembera") yokhala ndi 3 ml (300) ya kukonzekera kwa insulini ndi ntchito ya 100 IU / ml. Mutha kubaya kuchokera 1 mpaka 60 magawo a insulin pa jakisoni. Mutha kukhazikitsa muyeso wa gawo limodzi nthawi. Ngati mwakhazikitsa mayunitsi ambiri, mutha kusintha mankhwalawo popanda kutaya insulin.

Musanagwiritse ntchito cholembera cha SyPinge cha QuickPen ™, werengani bukuli lonse ndikutsatira malangizo ake ndendende. Ngati simutsatira malangizowa, mutha kulandira inshuwaransi yotsika kwambiri kapena kwambiri.

Pulogalamu yanu ya insulin ya QuickPen ™ iyenera kugwiritsidwa ntchito povulala panu. Osapatsira cholembera kapena singano kwa ena, chifukwa izi zimatha kufalitsa kachilomboka. Gwiritsani ntchito singano yatsopano jekeseni iliyonse.

Musagwiritse ntchito cholembera ngati gawo lake lina lawonongeka kapena lawonongeka.

Nthawi zonse tengani cholembera chopanda kanthu ngati mungataye cholembera kapena chikaonongeka.

Sitikulimbikitsidwa kugwiritsa ntchito cholembera cha syringe kwa odwala omwe ataya kuwona kwathunthu kapena kuwonongeka popanda kuthandizidwa ndi anthu omwe alibe mavuto amaso, ophunzitsidwa kugwira ntchito ndi cholembera.

Kukonzekera Kwachangu kwa Syninge™

Werengani ndikutsatira malangizo ogwiritsira ntchito mankhwalawa potsatira mankhwalawa.

Onani cholembera pa cholembera asanalowe jakisoni iliyonse kuti muwonetsetse kuti tsiku lakelo linatha ndipo mukugwiritsa ntchito mtundu woyenera wa insulini, musachotse chizindikiro pa cholembera.

Chidziwitso: Mtundu wa batani la syringe cholembera wa QuickPick ™ ulingana ndi mtundu wa Mzere pa cholembera cholembera ndipo zimatengera mtundu wa insulin. Mu buku ili, batani la mlingo limayimitsidwa. Mtundu wamtambo wa cholembera cha syringe cholembapo cha QuickPen ™ umawonetsera kuti umapangidwa kuti ugwiritse ntchito ndi zinthu za Humalog®.

Kukongoletsa Mtundu wa batani la Dose:

DNA imabweretsanso insulin ya anthu. Amasiyana ndi omwe amasinthidwa motsatizana mwa ma amino acid m'malo 28 ndi 29 a insulin B.

Choyambitsa chachikulu cha mankhwalawa ndi kuyamwa kwa kagayidwe kazakudya. Kuphatikiza apo, ili ndi anabolic zotsatira. Mu minofu ya minofu, pali kuchuluka kwa glycogen, mafuta acid, glycerol, kuchuluka kwa mapuloteni komanso kuwonjezereka kwa kumwa ma amino acid, koma nthawi yomweyo kumachepa mu glycogenolysis, gluconeogeneis, ketogeneis, lipolysis, proteinabolism ndi kutulutsidwa kwa ma amino acid.

Odwala omwe ali ndi mtundu woyamba wa 2 ndi mtundu wa 2 shuga, akamagwiritsa ntchito insulin lyspro, hyperglycemia yomwe imachitika chakudya itatha amachepetsa kwambiri poyerekeza ndi insulin yaumunthu. Kwa odwala omwe amalandira ma insulin achidule komanso ofunika, amafunika kusankha kuchuluka kwa ma insulin onse kuti tsiku lililonse azikhala ndi shuga.

Monga momwe akukonzekera insulin yonse, kutalika kwa nthawi ya lyspro insulin kumatha kukhala kosiyanasiyana mwa odwala kapena nthawi zosiyanasiyana wodwala yemweyo ndipo zimatengera mlingo, malo a jakisoni, magazi, kutentha kwa thupi ndi zochitika zolimbitsa thupi.

Mankhwala a lyspro insulin mwa ana ndi achinyamata ali ofanana ndi omwe amawonekera mwa akulu.

Odwala omwe ali ndi matenda a shuga a 2 omwe amalandila Mlingo wambiri wa sulfonylurea, kuwonjezera kwa insulin kumabweretsa kuchepa kwakukulu kwa hemoglobin wa glycated.

Mankhwala a Lyspro insulin odwala omwe ali ndi vuto la mtundu woyamba 1 komanso 2 amaperekedwera limodzi ndi kuchepa kwa ziwopsezo za nocturnal hypoglycemia.

Kuyankha kwa glucodynamic ku isulin lispro sikudalira kugwira ntchito kwa impso kapena chiwindi.

Lyspro insulin yawonetsedwa kuti imakhala yofanana ndi insulin yaumunthu, koma zochita zake zimachitika mwachangu kwambiri ndikukhalitsa kwakanthawi.

Lyspro insulin imadziwika ndi kuyamba mwachangu (pafupifupi mphindi 15), monga Ili ndi mayamwidwe ambiri, ndipo izi zimakupatsani mwayi woti mulowe musanadye (0-15 mphindi musanadye), mosiyana ndi insulin yachilendo (mphindi 30-45 musanadye). Lyspro insulin imakhala ndi nthawi yofupikirako (maola 2 mpaka 5) poyerekeza ndi insulin ya anthu wamba.

Zogulitsa ndi kugawa

Pambuyo pa kayendetsedwe ka sc, Lyspro insulin imatengedwa mwachangu ndikufika ku C_max mu madzi am'madzi pambuyo pa mphindi 30-70. V_d Lyspro insulin ndi insulin yabwinobwino yamunthu ndi yofanana ndipo ili mulifupi 0.26-0.36 l / kg.

Ndi sc director T_1/2 lyspro insulin ndi pafupifupi ola limodzi. Odwala omwe ali ndi impso ndi hepatic insufficiency amakhala ndi kuchuluka kwa kuyamwa kwa lyspro poyerekeza ndi insulin ya anthu.

- shuga mellitus mwa akulu ndi ana, omwe amafunikira chithandizo cha insulin kuti akhalebe ndi shuga.

Dokotala amawerengera aliyense payekha, kutengera zosowa za wodwalayo. Humalog ® imatha kuperekedweratu chakudya chisanafike, ngati kuli kofunika mukangomaliza kudya.

Kutentha kwa mankhwala omwe amaperekedwa kuyenera kukhala kutentha kwambiri.

Humalog ® imayendetsedwa s / c mwanjira zamajekeseni kapena m'njira yofikira ya kulowetsedwa kwa s / c pogwiritsa ntchito pampu ya insulin. Ngati ndi kotheka (ketoacidosis, matenda apakatikati, nthawi pakati pa ntchito kapena nthawi ya postoperative) Humalog ® ikhoza kulowa mkati / mkati.

SC iyenera kuperekedwa kwa phewa, ntchafu, matako, kapena pamimba. Masamba a jakisoni ayenera kusinthidwa kuti malo omwewo asagwiritsidwerenso nthawi 1 pamwezi. Mukamayambitsa mankhwala a Humalog ® pakukhazikitsidwa, chisamaliro chiyenera kutengedwa kuti mupewe magazi. Pambuyo pa jakisoni, tsamba la jakisidwe siliyenera kutenthedwa. Wodwala ayenera kuphunzitsidwa njira yolondola ya jakisoni.

Malangizo a makuponi a Humalog ®

Kukonzekera mawu oyamba

Mankhwala osokoneza bongo a Humalog ® ayenera kukhala owonekera komanso opanda khungu. Njira yothira ngati yafinya, kapena yakuwala pang'ono,

Mukakhazikitsa cartridge mu syringe cholembera (cholembera), ndikulowa ndi singano ndikuchita jakisoni wa insulin, ndikofunikira kutsatira malangizo a wopanga omwe amaphatikizidwa ndi cholembera chilichonse.

2. Sankhani tsamba la jakisoni.

3. Antiseptic kuchitira khungu malo jakisoni.

4. Chotsani kapu ku singano.

5. Sinthani khungu lanu mwakuutambasula kapena poteteza khola lalikulu. Ikani singano molingana ndi malangizo ogwiritsa ntchito cholembera.

6. Kanikizani batani.

7. Chotsani singano ndikufinya pang'onopang'ono malo a jakisoni kwa masekondi angapo. Osatupa malo a jakisoni.

8. Pogwiritsa ntchito singano, inaninso singano ndikuwononga.

9. Mawebusayiti ayenera kusinthidwa kuti malo omwewo asagwiritsenso ntchito nthawi 1 pamwezi.

I kuyang'anira insulin

Jekeseni wa intravenous wa Humalog ® uyenera kuchitika molingana ndi chizolowezi chachipatala cha jakisoni wamkati, mwachitsanzo, kulowetsedwa kwa bolus kapena kugwiritsa ntchito kulowetsedwa. Poterepa, nthawi zambiri ndikofunikira kulamula kuchuluka kwa shuga m'magazi.

Makina a kulowetsedwa okhala ndi zozungulira kuyambira 0,1 IU / ml mpaka 1,0 IU / ml insulin lispro mu 0,9% sodium chloride solution kapena 5% dextrose solution amakhala okhazikika firiji kwa maola 48.

Kulowetsedwa kwa insulin / P / C pogwiritsa ntchito pampu ya insulin

Potengera kulowetsedwa kwa Humalog ®, mapampu Ochepera ndi Disetronic amatha kugwiritsa ntchito kulowetsedwa kwa insulin. Muyenera kutsatira mosamalitsa malangizo omwe abwera ndi pampu. Njira ya kulowetsedwa imasinthidwa maola 48 aliwonse. Pakachitika vuto la hypoglycemic, kulowetsaku kumayimitsidwa mpaka gawo litatsimikiza. Ngati pali shuga wobwereza mobwerezabwereza kapena wochepa kwambiri m'magazi, ndiye kuti muyenera kudziwitsa dokotala za izi ndikuganiza kuchepetsa kapena kuletsa kulowetsedwa kwa insulin. Kuperewera kwa pampu kapena kufalikira mu dongosolo la kulowetsedwa kumatha kubweretsa kukwera msanga kwamagazi. Ngati mukukayikira kuti akuphwanya insulin, muyenera kutsatira malangizowo ndipo ngati kuli koyenera dziwitsani adokotala. Mukamagwiritsa ntchito pampu, kukonzekera kwa Humalog ® sikuyenera kusakanikirana ndi ma insulini ena.

Zotsatira zoyipa zomwe zimapezeka ndi mankhwala: hypoglycemia. Hypoglycemia yayikulu imatha kutha mphamvu ya chikumbumtima (hypoglycemic chikomokere), ndipo, mwatsatanetsatane, kufa.

Zotsatira zoyipa: thupi lawo siligwirizana angathe - redness, kutupa kapena kuyabwa pa jakisoni jekeseni (nthawi zambiri zimatha patadutsa masiku angapo kapena masabata), zokhudza zonse zomwe zimachitika (zimachitika kangapo, koma zimakhala zowopsa) - kuyabwa kwambiri, urticaria, angioedema, kutentha thupi, kufupika, kuchepa HELL, tachycardia, kuchuluka thukuta. Milandu yambiri yokhudzana ndimomwe thupi limagwirira ntchito ikhoza kukhala pachiwopsezo cha moyo.

Zomwe zimachitika: lipodystrophy pamalo a jekeseni.

- Hypersensitivity ku zigawo za mankhwala.

Mpaka pano, palibe zotsatira zosasangalatsa za Lyspro insulin pa mimba kapena thanzi la mwana wosabadwayo / wakhanda. Palibe kafukufuku wokhudzana ndi mliri omwe adachitika.

Cholinga cha mankhwala a insulin panthawi yapakati ndikusunga chiwongolero chokwanira cha glucose mwa odwala omwe ali ndi matenda a shuga a shuga kapena omwe amadwala matenda a shuga. Kufunika kwa insulin nthawi zambiri kumachepera mu trimester yoyamba ndikuwonjezeka muyezo wachiwiri ndi wachitatu wama trimesters apakati.Nthawi yobadwa pambuyo pokhapokha ndipo mwayamba kubadwa, zofunika za insulin zimatha kugwa kwambiri.

Akazi azaka zaubalaAnthu omwe ali ndi matenda ashuga ayenera kudziwitsa dokotala za mimba yomwe akukonzekera kapena yomwe ikukonzekera. Pa nthawi yoyembekezera, odwala matenda a shuga amafunika kuwunika mosamala kuchuluka kwa shuga m'magazi, komanso kuyang'aniridwa kawirikawiri kuchipatala.

Odwala omwe ali ndi matenda a shuga mellitus nthawi yoyamwitsa, kusintha kwa insulin ndi / kapena zakudya kungafunike.

Zizindikiro hypoglycemia, limodzi ndi zizindikiro zotsatirazi: ulesi, kuchuluka thukuta, tachycardia, mutu, kusanza, chisokonezo.

Chithandizo: Hypoglycemia yofewa nthawi zambiri imayimitsidwa ndi kulowerera kwa shuga kapena shuga wina, kapena zinthu zomwe zimakhala ndi shuga.

Kuwongolera kwa hypoglycemia moyenera kumatha kuchitika mothandizidwa ndi / m kapena s / c kukhudzana ndi glucagon, kenako kutsekeka kwa chakudya chamagulu pambuyo pakhazikika pakudwala. Odwala omwe samalabadira glucagon amapatsidwa njira ya iv dextrose (glucose).

Wodwala akakhala kuti akomoka, ndiye kuti glucagon uyenera kutumikiridwa / m kapena s / c. Pokhapokha glucagon kapena ngati palibe chochita ndi kayendetsedwe kake, ndikofunikira kuyambitsa njira yokhazikika ya dextrose (glucose). Atangozindikira, wodwalayo ayenera kupatsidwa chakudya chopatsa thanzi.

Zakudya zowonjezera zowonjezera zamafuta othandizira ndikuwunikira odwala zingafunike, popeza kuyambiranso kwa hypoglycemia ndikotheka.

Mphamvu ya Humalog's hypoglycemic imachepetsedwa ndi kulera kwapakamwa, corticosteroids, kukonzekera kwa mahomoni a chithokomiro, danazol, beta₂-adrenomimetics (kuphatikizapo rhytodrine, salbutamol, terbutaline), ma tridclic antidepressants, thiazide diuretics, chlorprotixen, diazoxide, isoniazid, lithiamu carbonate, nicotinic acid, zotumphukira za phenothiazine.

Zotsatira za hypoglycemic za Humalog zimapangidwira ndi ophatikiza ndi beta, ma ethanol ndi mankhwala okhala ndi ethanol, anabolic steroids, fenfluramine, guanethidine, tetracyclines, mankhwala apakamwa a hypoglycemic, salicylates (mwachitsanzo, acetylsalicylic acid, aniloprilactyl antagonists, MAP inhibitors, angiotensin II zolandila.

Humalog ® sayenera kusakanikirana ndi kukonzekera kwa insulin ya nyama.

Humalog ® ikhoza kugwiritsidwa ntchito (kuyang'aniridwa ndi dokotala) kuphatikiza ndi insulin ya anthu omwe amakhala nthawi yayitali kapena kuphatikiza ndi othandizira pakamwa a hypoglycemic, zotumphukira za sulfonylurea.

Mankhwala ndi mankhwala.

Mndandanda B. Mankhwalawa amayenera kusungidwa kuti ana asawafikire, mufiriji, kutentha kwa 2 ° mpaka 8 ° C, osazizira. Moyo wa alumali ndi zaka 2.

Mankhwala omwe amagwiritsidwa ntchito akuyenera kusungidwa kutentha 15th mpaka 25 ° C, otetezedwa ku dzuwa kapena kutentha mwachindunji. Moyo wa alumali - osaposa masiku 28.

Kufunika kwa insulin kumatha kuchepa ndi vuto la chiwindi.

Odwala omwe ali ndi hepatic insufficiency, kuchuluka kwa mayamwidwe a lyspro insulin kumakhalabe kuyerekezera ndi wamba insulin.

Kufunika kwa insulin kumatha kuchepa ndi kulephera kwa aimpso.

Odwala omwe amalephera kupweteka kwa impso, chiwopsezo chambiri cha lyspro insulin chimasungidwa poyerekeza ndi insulin yaumunthu.

Kusamutsa wodwala kupita ku mtundu wina kapena mtundu wa insulin kuyenera kuchitika moyang'aniridwa ndi achipatala. Kusintha kwa zochitika, mtundu (wopanga), mtundu (mwachitsanzo, Wokhazikika, NPH, Tepi), mitundu (nyama, anthu, ma insulin analogue) ndi / kapena njira yopanga (DNA recombinant insulin kapena insulini yachikhalidwe) ingafunike kusintha kwa mlingo.

Mikhalidwe yomwe zizindikiro zoyambirira za hypoglycemia zitha kukhala zosakhudzika komanso zochepa zomwe zimaphatikizidwa zimaphatikizapo kukhalapo kwa matenda a shuga, kulimbitsa kwambiri insulin, matenda amanjenje m'matenda a shuga, kapena mankhwala, monga beta-blockers.

Odwala omwe ali ndi vuto la hypoglycemic atasamutsidwa kuchokera ku insulin yochokera ku nyama kupita ku insulin yaumunthu, zizindikiro zoyambirira za hypoglycemia zitha kutchulidwa pang'ono kapena zosiyana ndi zomwe adakumana nazo kale ndi insulin. Hypoglycemic yosasinthika kapena ma hyperglycemic zomwe zimachitika zimatha kuyambitsa chikumbumtima, chikomokere, kapena kufa.

Mlingo wosakwanira kapena kusiya kulandira chithandizo, makamaka ndi matenda a shuga a shuga.

Kufunika kwa insulini kumatha kuchepa kwa odwala omwe amalephera kupweteka kwa impso, komanso kwa odwala omwe ali ndi vuto la chiwindi chifukwa cha kuchepa kwa njira ya gluconeogeneis ndi insulin metabolism. Komabe, mwa odwala omwe ali ndi vuto losatha la chiwindi, kukana kwa insulini kungayambitse kuchuluka kwa insulin.

Kufunika kwa insulin kumatha kuwonjezeka ndi matenda opatsirana, kupsinjika kwamalingaliro, ndikuwonjezereka kwa kuchuluka kwa chakudya chamagulu muzakudya.

Kusintha kwa mlingo kumafunikanso ngati wodwala akuchulukitsa kapena kusintha kwachilendo kwa zakudya. Kuchita masewera olimbitsa thupi mukangomaliza kudya kumawonjezera chiopsezo cha hypoglycemia. Zotsatira za pharmacodynamics za insulin analogi zomwe zimagwira mwachangu ndikuti ngati hypoglycemia imayamba, ndiye kuti imatha kupanga jekeseni m'mbuyomu kuposa kubayidwa insulin yamunthu.

Wodwalayo ayenera kuchenjezedwa kuti ngati dokotala atayambitsa kukonzekera kwa insulin ndi kuchuluka kwa 40 IU / ml mu vial, ndiye kuti insulini sayenera kutengedwa kuchokera ku cartridge ndi insulin ya 100 IU / ml ndi syringe ya jekeseni wa insulin wochita ndi 40 IU / ml.

Ngati kuli kofunikira kumwa mankhwala ena nthawi imodzi ndi Humalog ®, wodwalayo ayenera kufunsa dokotala.

Kukopa pa kuyendetsa magalimoto ndi kayendedwe kazinthu

Ndi hypoglycemia kapena hyperglycemia yolumikizana ndi mtundu wosakwanira wa dosing, kuphwanya kuthekera kwambiri komanso kuthamanga kwa zochitika zama psychomotor ndikotheka. Izi zitha kukhala pachiwopsezo cha zinthu zoopsa (kuphatikizapo kuyendetsa galimoto kapena kugwira ntchito ndi makina).

Odwala ayenera kusamala kuti apewe hypolycemia poyendetsa. Izi ndizofunikira kwambiri kwa odwala omwe ali ndi kuchepetsedwa kapena kusamvetseka kwa zizindikiro zoneneratu za hypoglycemia, kapena omwe zochitika za hypoglycemia ndizofala. Pazochitika izi, ndikofunikira kuyesa kuwongolera kutha kuyendetsa. Odwala omwe ali ndi matenda ashuga amatha kudzithandizira kuti amvetsetse Hypoglycemia wodwala ngati atenga glucose kapena zakudya zamafuta ambiri (tikulimbikitsidwa kuti nthawi zonse mumakhala ndi shuga g) pafupifupi 20 g. Wodwala ayenera kudziwitsa adokotala za hypoglycemia yosamutsidwa.

Insulin Humalog: momwe mungagwiritsire ntchito, kuchuluka kwake ndizovomerezeka komanso mtengo wake

Kanema (dinani kusewera).

Ngakhale kuti asayansi adakwanitsa kubwereza molekyulu yonse ya insulin, yomwe imapangidwa m'thupi la munthu, zochita za mahomoniwo zidasinthiratu chifukwa nthawi yomwe amafunika kunyamula magazi. Mankhwala oyamba osinthika anali insulin Humalog. Imayamba kugwira ntchito patangodutsa mphindi 15 jakisoni, choncho shuga yochokera m'mwaziyo imasamutsidwira minofu yake munthawi yake, ndipo ngakhale hyperglycemia yochepa siyimachitika.

Kanema (dinani kusewera).

Poyerekeza ndi ma insulins omwe adapangidwa kale, Humalog ikuwonetsa zotsatira zabwino: mwa odwala, kusinthasintha kwa tsiku ndi tsiku kwa shuga kumachepetsedwa ndi 22%, magirisi am'magazi amayenda bwino, makamaka masana, ndipo mwayi wa kuchepa kwambiri kwa hypoglycemia umachepa. Chifukwa chachangu, koma chokhazikika, insulin iyi imagwiritsidwa ntchito kwambiri mu shuga.

Malangizo ogwiritsira ntchito insulin Humalog ndiwosakhazikika, ndipo magawo omwe amafotokoza zoyipa ndi mayendedwe akugwiritsidwa ntchito amakhala ndi zigawo zingapo. Kufotokozera kwakutali komwe kumayendera limodzi ndimankhwala ena kumadziwika ndi odwala ngati chenjezo lokhuza kuwopsa kwawo. M'malo mwake, zonse ndizofanana: langizo lalikulu, latsatanetsatane - umboni wa mayesero ambirikuti mankhwalawa adapirira

Humalogue wavomerezedwa kuti agwiritse ntchito zaka 20 zapitazo, ndipo tsopano sizabwino kunena kuti insuliniyi ndi yotetezeka pa mlingo woyenera. Imavomerezedwa kuti agwiritsidwe ntchito ndi akulu ndi ana onse;

Zambiri pa Humalogue:

Mtundu woyamba wa matenda ashuga, mosasamala kanthu za matendawo.
Mtundu 2, ngati othandizira a hypoglycemic ndi zakudya samalola matenda a glycemia kuchepa.
Lembani 2 pakubala, matenda a shuga.
Mitundu yonse iwiri ya matenda a shuga panthawi ya mankhwala a ketoacidotic ndi hyperosmolar coma.

mankhwala zochizira matenda oopsa ndi okodzetsa,
kukonzekera kwa mahomoni, kuphatikizapo njira zakulera za pakamwa,
nicotinic acid amagwiritsa ntchito pofuna kuchiza matenda ashuga.

Limbikitsani izi:

mowa
othandizira a hypoglycemic omwe amagwiritsidwa ntchito pochiza matenda amitundu iwiri,
Asipirin
gawo la antidepressants.

Ngati mankhwalawa sangasinthidwe ndi ena, mlingo wa Humalog uyenera kusintha kwakanthawi.

Zina mwazotsatira zoyipa, hypoglycemia ndi thupi lawo siligwirizana nthawi zambiri zimawonedwa (1-10% ya odwala matenda ashuga). Osakwana 1% odwala amakhala ndi lipodystrophy pamalo opangira jekeseni. Makulidwe azinthu zina zoyipa amakhala ochepera 0.1%.

Kunyumba, Humalog imayendetsedwa pang'onopang'ono pogwiritsa ntchito cholembera kapena pampu ya insulin. Ngati matenda oopsa a hyperglycemia atachotsedwa, mankhwala osokoneza bongo amathandizanso kuchipatala. Pankhaniyi, kuthana ndi shuga pafupipafupi ndikofunikira kupewa bongo.

Chithandizo chogwira ntchito cha mankhwala ndi insulin lispro. Amasiyana ndi mahomoni amunthu pakupanga ma amino acid mu molekyulu. Kusintha koteroko sikulepheretsa ma cell receptors kuzindikira mahomoni, chifukwa chake amapatsira shuga mwa iwo okha. Chiwonetserochi chimakhala ndi ma insulin monomers okha - mamolekyulu osalumikizana. Chifukwa cha izi, imakamizidwa mwachangu komanso moyenera, imayamba kuchepetsa shuga mwachangu kuposa insulin yachilendo.

Humalog ndi mankhwala ofupikitsika kuposa, mwachitsanzo, Humulin kapena Actrapid. Malinga ndi gulu, amatchulidwa ndi ma insulin omwe ali ndi ultrashort action. Kukhazikika kwa ntchito yake kumachitika mwachangu, pafupifupi mphindi 15, kotero odwala matenda ashuga sayenera kudikirira mpaka mankhwalawo atagwira, koma mutha kukonzekera chakudya mukangobaya jakisoni. Chifukwa cha kufupika kwakanthawi, kumakhala kosavuta kukonza zakudya, ndipo chiopsezo cha kuiwala chakudya jakisoni itachepa.

Kuti muthane ndi vuto labwino la glycemic, insulin yothamanga imayenera kuphatikizidwa ndi kuvomerezedwa kwa insulin yayitali. Chokha chosiyana ndi kugwiritsa ntchito pampu ya insulin nthawi zonse.

Mlingo wa Humalog umatengera zinthu zambiri ndipo umatsimikiziridwa payekhapayekha kwa aliyense wodwala matenda ashuga. Kugwiritsa ntchito njira zoyenera sikulimbikitsidwa, popeza zimakulitsa kubwezeretsanso shuga. Ngati wodwala amatsatira zakudya zamafuta ochepa, mlingo wa Humalog umakhala wocheperako kuposa momwe oyang'anira angapangire. Pankhaniyi, tikulimbikitsidwa kugwiritsa ntchito insulin yofulumira.

Hormashort ya Ultrashort imapereka mphamvu kwambiri. Mukasinthira ku Humalog, mlingo wake woyambirira amawerengedwa ngati 40% ya insulin yayifupi. Malinga ndi zotsatira za glycemia, mlingo umasinthidwa. Chofunikira pakukonzekera mkate uliwonse ndimagawo 1-1,5.

Chakudya chimayalidwa chakudya chilichonse chisanachitike. osachepera katatu patsiku. Pankhani ya shuga wambiri, mawonekedwe okhathamira pakati pa jakisoni wamkulu amaloledwa. Malangizo ogwiritsira ntchito akutsimikizira kuwerengera kuchuluka kwa insulini yochokera pamafuta omwe akukonzekera chakudya chotsatira. Pafupifupi mphindi 15 ayenera kuchokera jakisoni kupita chakudya.

Malinga ndi ndemanga, nthawi ino nthawi zambiri zimakhala zochepa, makamaka masana, pomwe insulin kukana imakhala yotsika. Mlingo wa mayamwidwe ndi munthu payekhapayekha, umatha kuwerengeka pogwiritsa ntchito kuchuluka kwa shuga m'magazi pambuyo pobayidwa. Ngati kutsitsa kwa shuga kumawonedwa mwachangu kuposa momwe malangizowo amafunikira, nthawi yomwe chakudya chisanachitike iyenera kuchepetsedwa.

Humalog ndi imodzi mwamankhwala omwe amafulumira kwambiri, chifukwa chake nchosavuta kugwiritsa ntchito ngati thandizo ladzidzidzi kwa matenda ashuga ngati wodwala akuwopseza kuti ali ndi vuto la hyperglycemic.

Peak ya insulin ya ultrashort imawonedwa patatha mphindi 60 kuchokera pakukhazikitsa. Kutalika kwa zochita zimatengera mlingo; kukula kwake ndikutalika kwa shuga, pafupifupi - pafupifupi maola 4.

Kusakaniza kwa Humalog 25

Kuti muwone molondola momwe Humalog ikuyendera, shuga ayenera kuyesedwa pambuyo pa nthawi imeneyi, nthawi zambiri izi zimachitika chakudya chotsatira chisanachitike. Miyeso yoyambirira imafunikira ngati hypoglycemia ikukayikira.

Kutalika kwakanthawi kwa Humalog si koyipa, koma mwayi wa mankhwalawa. Tikuthokoza, odwala omwe ali ndi matenda osokoneza bongo sakhala ndi vuto la hypoglycemia, makamaka usiku.

Kodi mumazunzidwa ndi kuthamanga kwa magazi? Kodi mukudziwa kuti matenda oopsa amachititsa kuti mtima ukhale mwamantha ndi kuwakwiyitsa? Sinthani nkhawa zanu. Maganizo ndi mayankho okhudza njira zomwe mwawerenga apa >>

Kuphatikiza pa Humalog, kampani yopanga zamankhwala Lilly France imatulutsa Humalog Remix. Ndiosakanikirana kwa lyspro insulin ndi protamine sulfate. Chifukwa cha kuphatikiza uku, nthawi yoyambira ya mahomoni imakhalabe mwachangu, ndipo nthawi yochitapo kanthu imawonjezeka kwambiri.

Kusintha kwa Humalog kumapezeka mu 2indi:

Malangizo ogwiritsira ntchito insulin Humalog yothandizira osakhalitsa (yankho ndi kuyimitsidwa Kusakaniza)

Mankhwala apamwamba kwambiri achi French, a insulin Humalog, atsimikizira kuti ndi apamwamba kuposa ma analogues, omwe amapezeka chifukwa chophatikizika bwino pazinthu zazikulu zomwe zimagwira ntchito. Kugwiritsa ntchito insulini iyi kumathandizanso kwambiri kuti athane ndi hyperglycemia mwa odwala omwe ali ndi matenda ashuga.

Insulin Humalog Yachidule imapangidwa ndi kampani yaku France ya Lilly France, ndipo mawonekedwe ake otulutsidwa ndi njira yosavuta komanso yopanda utoto, yokhazikitsidwa ndi kapisolo kapena cartridge. Zotsalazo zitha kugulitsidwa zonse ngati gawo la syringe yokonzedwa kale, kapena padera magawo asanu pa 3 ml pachimake. Monga njira ina, makonzedwe angapo a Humalog Mix amapangidwa mwa kuyimitsidwa kwa kayendetsedwe koyenda, pomwe Humalog Remix imatha kutumikiridwa kudzera m'mitsetse.

Chofunikira chachikulu cha Humalog ndi insulin lispro - mankhwala a magawo awiri pa 100 IU pa 1 ml ya yankho, zomwe zimayendetsedwa ndi zigawo zina zowonjezera:

glycerol
metacresol
zinc oxide
sodium hydrogen phosphate heptahydrate,
hydrochloric acid solution,
sodium hydroxide solution.

Kuchokera pakuwona kwa gulu lazachipatala ndi zamankhwala, Humalog amatanthauza kufananizira kwa insulin yaumunthu yochepa, koma imasiyana ndi iwo m'njira zotsatizana za ma amino acid.Ntchito yayikulu ya mankhwalawa ndikuwongolera kutulutsa kwa glucose, ngakhale ilinso ndi katundu wa anabolic. Pharmacologically, imachita motere: kuwonjezeka kwa glycogen, mafuta acids ndi glycerol kumapangidwira minofu minofu, komanso kuwonjezeka kwa kuchuluka kwa mapuloteni komanso kumwa kwa amino acid ndi thupi. Mofananamo, njira monga glycogenolysis, gluconeogeneis, lipolysis, mapuloteni catabolism, ndi ketogeneis zimayamba kuchepa.

Kafukufuku wasonyeza kuti mwa odwala omwe ali ndi mitundu yonse ya shuga m'matumbo atatha kudya, kuchuluka kwa shuga kumachepa kwambiri ngati Humalog imagwiritsidwa ntchito m'malo mwa insulin ina yosungunuka.

Ndikofunika kukumbukira kuti ngati wodwala yemwe ali ndi matenda ashuga nthawi yomweyo amalandira insulin yochepa komanso basal insulin, ndikofunikira kusintha mlingo wa mankhwala oyamba ndi achiwiri kuti mukhale ndi zotsatira zabwino. Ngakhale kuti Humalog ndi ya ma insulin osakhalitsa, nthawi yotsiriza yochita zake imatsimikizidwa ndi zinthu zingapo payekha kwa wodwala aliyense:

Mlingo
tsamba la jakisoni
kutentha kwa thupi
zolimbitsa thupi
mtundu wamagazi.

Payokha, ndikofunikira kudziwa kuti Humalog insulin imathandizanso chimodzimodzi kwa odwala matenda ashuga komanso pa ana kapena achinyamata. Sizosasinthika kuti mphamvu ya mankhwalawa sizimadalira kupezeka kwa aimpso kapena chiwindi m'thupi, ndipo akaphatikizidwa ndi Mlingo wambiri wa sulfonylurea, kuchuluka kwa hemoglobin ya glycated kumachepa kwambiri. Mwambiri, pakhala pali kuchepa kwakukulu kwa chiwerengero cha nocturnal hypoglycemia, pomwe odwala matenda ashuga nthawi zambiri amavutika ngati samamwa mankhwala oyenera.

Makhalidwe a Humalog insulin omwe akuwonetsedwa manambala amawoneka motere: kuyambika kwa mphindi 15 pambuyo pa jakisoni, nthawi yochitapo kanthu ikuchokera maola awiri mpaka asanu. Kumbali ina, kugwiritsa ntchito bwino mankhwalawa kumakhala kotsika poyerekeza ndi komwe kumachitika panjira, ndipo winayo amatha kugwiritsidwa ntchito mphindi 15 asanadye, osati 30-31, monga momwe zimakhalira ndi ma insulini ena.

Insulin Humalog imapangidwira odwala onse omwe ali ndi vuto la hyperglycemia ndipo amafuna insulin. Itha kukhala funso la mitundu iwiri ya matenda ashuga a mellitus, omwe ndi matenda omwe amadalira insulin, ndi matenda amtundu wa 2, omwe shuga ya magazi amawonjezeka pafupipafupi pambuyo chakudya chomwe chimakhala ndi chakudya.

Insulin Humalog-yofikira mwachidule imakhala othandiza nthawi iliyonse yamatendawa, komanso kwa odwala onse azaka ndi azaka zonse. Monga mankhwala othandiza, kuphatikiza kwake ndi ma insulin apakati komanso a nthawi yayitali, omwe amavomerezedwa ndi adokotala, amawaganiziridwa.

Pali magawo awiri okhazikitsidwa omwe amachititsa kuti munthu agwiritse ntchito Humalog: kusalolerana kwa chinthu chimodzi kapena chinzake cha mankhwala ndi hypoglycemia, pomwe mankhwala a hypoglycemic amangokulitsa zoyipa mthupi. Komabe, mawonekedwe ndi zizindikiro zingapo ziyenera kukumbukiridwa mukamagwiritsa ntchito insulin iyi:

Kafukufuku sanawonetse mavuto aliwonse a Humalog paumoyo komanso thanzi la mwana wosabadwa (komanso mwana wakhanda),
chithandizo cha insulin chimawonetsedwa kwa amayi apakati omwe ali ndi matenda okhudzana ndi insulin kapena matenda a gestational, ndipo potengera izi, ziyenera kukumbukiridwa kuti kufunika kwa insulini kumayamba kuchepa mu trimester yoyamba, kenako ndikuwonjezeka ndi wachiwiri ndi wachitatu trimesters. Pambuyo pobadwa mwana, kufunikira kumeneku kumatha kuchepa kwambiri, komwe kuyenera kukumbukiridwa,
pokonzekera kukhala ndi pakati, mayi yemwe ali ndi matenda ashuga azikambirana ndi adotolo, ndipo mtsogolomo, kuwunika mosamala za momwe aliri kungafunike,
mwina kufunika kokonza kuchuluka kwa Humalog panthawi yoyamwitsa, komanso kukonza zakudya,
odwala matenda ashuga omwe ali ndi aimpso kapena a hepatic insuffuffing amakhala ndi mayamwa mofulumira a Humalog poyerekeza ndi ma insulin ena.
Kusintha kwina kwa mankhwala a insulin kumafunikira dokotala: kusintha mtundu wina wa insulin, kusintha mtundu wa mankhwalawo, kusintha zolimbitsa thupi.

Owerenga mabakera anena zowona zonse zokhudza matenda ashuga! Matenda a shuga amapita pakatha masiku 10 ngati mumamwa m'mawa. »Werengani zambiri >>>

Kumbukirani kuti kugwiritsa ntchito kwambiri mankhwala a insulin kungayambitse vuto losakhazikika kapena kutanthauziridwa pang'ono kwa hypoglycemia (izi zimagwiranso ntchito pakusintha kwa wodwala kuchoka ku insulin ya nyama kupita ku Humalog). M'pofunikanso kuganizira kuti kuchuluka kwa mankhwalawa mopitirira muyeso ndikutha kugwiritsa ntchito kwake kungayambitse hyperglycemia. Kufunika kwa odwala matenda ashuga a insulin kumawonjezereka ndikuphatikizira kwa shuga ku matenda opatsirana kapena kupsinjika.

Zotsatira zake zoyipa, mankhwala omwe amagwiritsidwa ntchito angagwiritse ntchito hypoglycemia, pomwe kuphatikiza kwa othandizira ena mwanjira zina kuyambitsa:

thupi lawo siligwirizana (redness kapena kuyabwa pa malo jakisoni),
zokhudza thupi lawo siligwirizana (kuyabwa konse, urticaria, malungo, edema, tachycardia, kutsitsa magazi, kutuluka kwambiri),
lipodystrophy pamalo a jekeseni.

Pomaliza, bongo wambiri wa Humalog umatsogolera ku hypoglycemia yayikulu ndi zotsatirapo zonse: kufooka, thukuta kwambiri, kusokonekera kwa mtima, mutu ndi kusanza. Hypoglycemic syndrome imayimitsidwa ndi miyezo yokhazikika: kumeza shuga kapena chinthu china chokhala ndi shuga.

Kugwiritsa ntchito Humalog kumayambira powerengera mlingo, womwe umatsimikiziridwa payekha ndi adotolo, kutengera ndi kusowa kwa matenda a shuga. Mankhwalawa atha kuperekedwa musanadye komanso pambuyo poti mudye, ngakhale njira yoyamba ndiyabwino. Onetsetsani kuti mukukumbukira kuti yankho siliyenera kuzizira, koma likufanizira kutentha kwa chipinda. Nthawi zambiri, syringe, cholembera, kapena pampu ya insulini imagwiritsidwa ntchito poigwiritsa ntchito, jekeseni mwanjira ina, komabe, pazinthu zina, kulowetsedwa kwa kulowetsedwa kumaloledwa.

Jakisoni wotsekemera amachitika makamaka m'tchafu, phewa, pamimba kapena matako, kusinthana malo a jekeseni kuti chinthu chomwecho sichikugwiranso ntchito kamodzi pamwezi. Kusamalidwa kuyenera kuthandizidwa kuti musalowe m'mitsempha, komanso sikulimbikitsidwa kutikita pakhungu pambuyo poti mwabayidwa. Ma humalog omwe adagulidwa ngati mawonekedwe a cartridge a syringe cholembera agwiritsidwa ntchito motere:

muyenera kusamba m'manja ndi madzi ofunda ndikusankha malo a jekeseni,
khungu m'malo jakisoni ndi opha tizilombo toyambitsa matenda,
chophimba chimachotsedwa pa singano.
Khungu limakonzedwa pamanja pokoka kapena kukanikiza kuti khola lipezeke,
singano imayilidwa pakhungu, batani la syringe limakanikizidwa,
singano imachotsedwa, tsamba la jakisalo limakanikizidwa modekha kwa masekondi angapo (popanda kutsitsa ndi kutikisa),
mothandizidwa ndi kapu yoteteza, singanoyo imatembenuzidwa ndikuchotsedwa.

Malamulo onsewa amagwira ntchito pamitundu yotere ya mankhwalawa monga Humalog Remix 25 ndi Humalog Remix 50, yopangidwa mwanjira yoyimitsidwa. Kusiyanako kuli pakuwoneka ndi kukonzekera kwa mitundu yosiyanasiyana ya mankhwala: yankho lake liyenera kukhala lopanda utoto komanso wowonekera, pomwe limakhala lokonzeka kugwiritsidwa ntchito, pomwe kuyimitsidwa kwake kuyenera kugwedezeka kangapo kuti katoni ikhale ndi yunifolomu, yamitambo, yofanana ndi mkaka.

Kuwongolera kwapakati pa Humalog kumachitika pang'onopang'ono pogwiritsa ntchito njira yolumikizira, momwe yankho limaphatikizidwa ndi yankho la 0.9% sodium chloride kapena 5% dextrose solution. Kugwiritsa ntchito mapampu a insulin poyambitsa Humalog amakonzedwa molingana ndi malangizo omwe aphatikizidwa ndi chipangizocho. Mukamagwira jakisoni wamtundu uliwonse, muyenera kukumbukira kuchuluka kwa shuga komwe kumachepetsa 1 insulin kuti muwoneke molondola mlingo ndi momwe thupi limagwirira. Pa avareji, chizindikirochi ndi 2.0 mmol / L pokonzekera ma insulin ambiri, zomwe zimachitikiranso Humalog.

Kuphatikiza kwa mankhwalawa kwa Humalog ndi mankhwala ena ambiri kumafanana ndi kufanana kwake. Chifukwa chake, zotsatira za hypoglycemic yothetsera vutoli zimachepetsedwa ndikuphatikizidwa ndi njira yolerera pakamwa, glucocorticosteroids, mahomoni a chithokomiro, mitundu yambiri ya okodzetsa ndi antidepressants, komanso nicotinic acid.

Nthawi yomweyo, mphamvu ya insulin iyi imakulirakulira pamodzi ndi mankhwala pogwiritsa ntchito:

beta blockers,
Mowa ndi mankhwala ozikirapo,
anabolic steroids
othandizira otsegula pakamwa,
sulfonamides.

Humalog iyenera kusungidwa m'malo osavomerezeka ndi ana mkati mwa firiji wamba, kutentha kwa +2 mpaka +8 digiri Celsius. Moyo wa alumali wamba ndi zaka ziwiri. Ngati phukusi latsegulidwa kale, insulini iyi iyenera kusungidwa kutentha kutentha +15 mpaka +25 Celsius.

Chisamaliro chikuyenera kuthandizidwa kuti mankhwalawa asatenthe komanso kuti alibe dzuwa. Mukayamba kuyamba kugwiritsa ntchito, moyo wa alumali umachepetsedwa kukhala masiku 28.

Zofananira mwachindunji za Humalog zikuyenera kuwonedwa ngati kukonzekera konse kwa insulin kumathandizanso odwala matenda ashuga chimodzimodzi. Mwa zina mwazotchuka kwambiri ndi Actrapid, Vosulin, Gensulin, Insugen, Insular, Humodar, Isofan, Protafan ndi Homolong.

Kwa odwala omwe ali ndi matenda a shuga 1, ma jakisoni a insulin ndi njira zofunika tsiku lililonse zomwe zimathandizira kuti shuga azikhala bwino.

Masiku ano, pali mitundu yambiri ya mankhwalawa.

Odwala amayankha bwino mankhwala a Humalogmix, omwe ali ndi mitundu yosiyanasiyana yotulutsidwa. Komanso, lembalo limafotokoza malangizo ogwiritsa ntchito.

Humalog ndi mankhwala osokoneza bongo omwe ali ndi insulin yachilengedwe yopangidwa ndi thupi la munthu. DNA ndi njira yosinthira. Chodabwitsa ndichakuti Humalog imasintha kapangidwe ka amino acid m'maketeni a insulin. Mankhwala amawongolera kagayidwe kakang'ono ka shuga m'thupi. Zimatengera mankhwala okhala ndi zotsatira za anabolic.

Kubayidwira mankhwala kumathandizira kukulitsa kuchuluka kwa glycerol, acid acid ndi glocogen m'thupi. Imathandizira kuthamangitsa kaphatikizidwe ka mapuloteni. Njira yothetsera kumwa kwa amino acid imathandizira, zomwe zimapangitsa kuchepa kwa ketogeneis, glucogenogeneis, lipolysis, glycogenolysis, mapuloteni catabolism. Mankhwalawa ali ndi kanthawi kochepa.

Gawo lalikulu la Humalog ndi insulin lispro. Komanso, zikuchokera zimathandizirana ndi omwe amapezeka kwawo. Palinso mitundu yosiyanasiyana ya mankhwalawa - Humalogmix 25, 50 ndi 100. Kusiyanitsa kwake kwakukulu ndi kukhalapo kwa Hagedorn mu proitamin yosalowerera, yomwe imachepetsa mphamvu ya insulin.

Manambala 25, 50 ndi 100 akuwonetsa kuchuluka kwa NPH pamankhwala. Humalogmix yowonjezereka yomwe imakhala ndi kulowererapo kwa Hagedorn, m'pamenenso mankhwala omwe angagwiridwe ntchito amatha kuchita. Chifukwa chake, mutha kuchepetsa kufunika kwa jakisoni yambiri, yopangidwira tsiku limodzi. Kugwiritsa ntchito mankhwalawa kumathandizira kuchiza matenda okoma komanso kumapangitsa moyo kukhala wosavuta.

Monga mankhwala aliwonse a Humalogmix 25, 50 ndi 100 ali ndi zovuta.

Mankhwala salola kupanga chiwonetsero chokwanira pa magazi a shuga.

Palinso milandu yokhudzana ndi chifuwa cha mankhwalawa ndi zovuta zina. Madokotala nthawi zambiri amapereka insulin Humalog mu mawonekedwe oyera m'malo osakanikirana, chifukwa mankhwalawa a NPH 25, 50 ndi 100 angayambitse zovuta za matenda ashuga, nthawi zambiri amatha kudwala. Ndiwothandiza kwambiri kugwiritsa ntchito mitundu komanso mankhwalawa pochiza odwala okalamba omwe ali ndi matenda ashuga.

Nthawi zambiri, kusankha kwa mankhwala oterowo kumachitika chifukwa chakuyembekezerera kwakanthawi kochepa kwa odwala komanso kukula kwa demokalase. Pazigawo zotsala za odwala, Humalog mu mawonekedwe ake oyera amalimbikitsidwa.

Momwe mungasungire shuga kukhala wabwinobwino mu 2019

Makalata ochokera kwa Owerenga

Agogo anga akhala akudwala matenda a shuga kwa nthawi yayitali (mtundu 2), koma posachedwapa mavuto atuluka pamiyendo ndi ziwalo zamkati.

Mwangozi ndidapeza nkhani pa intaneti yomwe idapulumutsa moyo wanga. Zinali zovuta kuti ndione chizunzo, ndipo fungo loipa m'chipindacho linali kundiyambitsa misala.

Kupyola nthawi ya chithandizo, agogo aja adasinthanso momwe akumvera. Ananenanso kuti miyendo yake sikupweteka komanso zilonda zake sizinayende; sabata yamawa tidzapita ku ofesi ya dotolo. Falitsa ulalo wa nkhaniyo

Mankhwalawa amapezeka ngati kuyimitsidwa kwa jakisoni pansi pa khungu. The yogwira ndi insulin lispro 100 IU.

Zowonjezera zinalembedwe:

1.76 mg metacresol,
0,80 mg wa phenol madzi,
16 mg a glycerol (glycerol),
0,28 mg proitamin sulfate,
3,78 mg wa sodium hydrogen phosphate,
25 mcg wa zinc oxide,
10% hydrochloric acid solution,
Kufikira 1 ml ya madzi a jakisoni.

Thupi limayera ndi utoto, wokhoza kufalikira. Zotsatira zake zimakhala zoyera komanso zamadzimadzi zomveka zomwe zimasonkhana pamwamba pa mpweya. Kuti mupeze jakisoni, ndikofunikira kusakaniza madzi omwe amapangidwa ndi matope mwa kugwedeza mopepuka ma ampoules. Humalog ikukhudzana ndi njira zophatikiza ma insulin achilengedwe ndi nthawi yayitali komanso yochepa kuchitira.

Osakaniza 50 quicpen ndi osakaniza achilengedwe ochita mwachangu insulin (insulin solution lispro 50%) ndi sing'anga kanthu (proitamin kuyimitsidwa insulin lispro 50%).

Cholinga cha chinthu ichi ndikuwongolera kagayidwe kachakudya ka shuga m'thupi. Zochita za Anabolic komanso zotsutsa-catabolic m'maselo osiyanasiyana a thupi zimadziwikanso.

Lizpro ndi insulin, yomwe imafanananso ndi mahomoni opangidwa m'thupi la munthu, ngakhale kuchepa kwathunthu kwa shuga mumagazi kumachitika mwachangu, koma zotsatira zake zimakhala zochepa. Kumwirira kwathunthu m'magazi ndikuyamba kwa zomwe zikuyembekezeka kuchitazi mwachindunji zimatengera zifukwa zingapo:

Masamba a jekeseni (kulowetsa pamimba, m'chiuno, matako),
Mlingo (kuchuluka kwa insulini),
kayendedwe ka magazi
kutentha kwa thupi kwa wodwalayo
kulimbitsa thupi.

Mutapanga jakisoni, mphamvu ya mankhwalawa imayamba pakatha mphindi 15 zotsatira. Nthawi zambiri, kuyimitsidwa kumayikidwa pakhungu pakatsala mphindi zochepa chakudya chisanachitike, zomwe zimathandiza kuti pasapezeke shuga. Poyerekeza, mphamvu ya lyspro insulin ingafaniziridwe ndi zomwe amachita ndi insulin ya munthu - isophan, yemwe zochita zake zimatha mpaka maola 15.

Ponena za kugwiritsa ntchito moyenera mankhwalawa monga Humalogmix 25, 50 ndi 100, malangizo ogwiritsira ntchito adzafunika. Tiyenera kukumbukira kuti mankhwalawa amagwiritsidwa ntchito mu matenda a shuga pochiza odwala amisinkhu yosiyanasiyana, kwa moyo wabwinobwino womwe insulin imafunikira tsiku ndi tsiku. Mlingo wofunikira komanso kuchuluka kwa makonzedwe kungathe kutsimikiziridwa ndi dokotala.

Pali njira zitatu zovomerezeka:

Timapereka kuchotsera kwa owerenga tsamba lathu!

Akatswiri okhawo omwe amatha kuperekera mankhwalawa mwachisawawa mu mawonekedwe a inpatient. Izi ndichifukwa choti kudziyang'anira wekha mwanjira imeneyi kumakhala ndi zoopsa zina. Insulin yomwe ili mu cartridge idapangidwa kuti iziziritsa cholembera kwa odwala matenda ashuga. Kuyambitsa motere kumachitika kokha pakhungu.

Humalog imalowetsedwa m'thupi kupitilira mphindi 15. musanadye, kapena mwachangu mphindi imodzi mutatha kudya. Pafupipafupi jakisoni amatha kusiyanasiyana kanayi mpaka katatu patsiku limodzi. Odwala akamamwa insulin yayitali, jakisoni wa mankhwalawa amachepetsedwa katatu pa tsiku. Ndi choletsedwa kupitirira muyeso wokwanira womwe madokotala amapereka ngati palibe chifukwa chofunikira chofunikira.

Kufanana ndi mankhwalawa, ma fanizo ena a mahomoni achilengedwe amaloledwa. Imayendetsedwa ndikuphatikizira zinthu ziwiri mu cholembera chimodzi, zomwe zimapangitsa kuti jakisoni azikhala mosavuta, osavuta komanso otetezeka. Jekeseni asanayambe, katoni ndi zinthuzo zimayenera kusakanikirana mpaka osalala, kugudubuza m'manja mwanu. Simungagwedezeni chidebe ndi mankhwalawa kwambiri, popeza pali chiopsezo chopanga chithovu, kuyambitsa kwake komwe sikofunikira.

Malangizowa akutsatira momwe ntchito ikuyendera, momwe mungagwiritsire ntchito Humalogmix molondola:

Choyamba, muyenera kusamba manja anu bwino, kugwiritsa ntchito sopo nthawi zonse.
Tsimikizani tsamba la jakisoni, lipukuteni ndi disk disk.
Ikani cartridge mu syringe, ndikugwedezani pang'onopang'ono mbali zosiyanasiyana. Chifukwa chake chinthucho chimakhala chofanana, chimakhala chowonekera komanso chosakongola. Gwiritsani ntchito ma cartridge okha ndi amadzimadzi opanda zotsalira.
Sankhani mlingo wofunikira pakulipira.
Tsegulani singano pochotsa kapu.
Konzani khungu.
Ikani singano yonse pansi pa khungu. Kukwaniritsa mfundoyi, muyenera kusamala kuti musalowe muzombo.
Tsopano muyenera kukanikiza batani, gwiritsitsani.
Yembekezerani chizindikirocho kuti mutsirize kukonzekera kwa mankhwalawo kuti mumveke, werengani masekondi 10. ndi kutulutsa syringe. Onetsetsani kuti mlingo wosankhidwa ukuperekedwa kwathunthu.
Ikani chimbale cha zidakwa pamalowo a jakisoni. Mulimonsemo muyenera kukanikiza, kupukuta kapena kupukusa malo a jekeseni.
Tsekani singano ndi kapu yoteteza.

Mukamagwiritsa ntchito mankhwalawa, muyenera kudziwa kuti zinthu zomwe zili mu cartridge ziyenera kuzitenthesa m'manja mwanu kuti zizitentha kwambiri. Kukhazikitsidwa pansi pa khungu la mankhwala ndi syringe cholembera kumachitika mu ntchafu, phewa, pamimba kapena matako. Ndikupangiratu kuti musapange jekeseni malo omwewo. Gawo la thupi lomwe insulin imalowetsedwa mwezi uliwonse liyenera kusinthidwa. Muyenera kugwiritsa ntchito Humalog pokhapokha ngati muyeza ma glucose ndi glucometer kuti mupewe kukula kwa zovuta.

Anthu ambiri omwe ali ndi matenda a shuga akhala akugwiritsa ntchito Humalogmix insulin 25, 50 ndi 100 kwazaka zambiri. Malinga ndi ndemanga zosiyanasiyana, koma zabwino zambiri.

Ndakhala ndikudwala matenda ashuga kwa zaka zoposa 10. Humalog yomwe wapeza kumene, yomwe imatha kudindidwa ndi cholembera. Fomu yabwino yoyambira ndipo nthawi zonse ili pafupi. Amasangalatsa ndi mwachangu kuchitapo kanthu kwa mankhwalawa, omwe safunika kudikira. Izi zisanachitike, osakaniza a Actrapid ndi Protafan adabayidwa, koma nthawi zambiri amayenera kuthana ndi hypoglycemia. Ndipo Humalog adathandizira kuiwala za zovutazi.

Mwana wanga wamkazi ali ndi matenda ashuga 1 kwa zaka zitatu. Zaka zonsezi akhala akufunafuna anzawo othamanga. Pofufuza mankhwala omwe akhala akuchita kwa nthawi yayitali, mavuto ngati amenewa sanabuke. Mwa kuchuluka kwamankhwala omwe amadziwika bwino, Humalog - cholembera cha syringe cha Quickpein - adachita chidwi kwambiri. Kuchitapo kanthu kumamveredwa kale kuposa ena onse. Takhala tikugwiritsa ntchito mankhwalawa kwa miyezi 6 ndipo tasiya kufunafuna zabwino.

Ndakhala ndi matenda ashuga kwa nthawi yayitali. Ndimadwala matenda osokoneza bongo osalekeza. Posachedwa, adokotala adalemba Humalog. Tsopano zinthu zakhala bwino, palibe kuwonongeka kowopsa. Chokhacho chomwe sichikondweretsa ndi mtengo wokwera.

Matenda a shuga nthawi zonse amayambitsa zovuta zakupha. Mwazi wamagazi ochulukirapo ndi woopsa kwambiri.

A Alexander Myasnikov mu Disembala 2018 adapereka chidziwitso chokhudza chithandizo cha matenda ashuga. Werengani kwathunthu

Kufotokozera kogwirizana ndi 31.07.2015

Dzina lachi Latin: Humalog
Code ya ATX: A10AB04
Chithandizo: Insulin Lizpro
Wopanga: Lilly France S. A. S., France

Insulin Lizpro, glycerol, metacresol, zinc oxide, sodium hydrogen phosphate heptahydrate, hydrochloric acid (sodium hydroxide solution), madzi.

Njira yothetsera vutoli ndi yopanda utoto, yowonekera m'makatoreji atatu a 3 ml mu paketi yonyamula m'makatoni olemba nambala 15.
Katoni yomwe ili mu cholembera cha syringe ya QuickPen (5) ili pabokosi la makatoni.
Humalog Remix 50 ndi Humalog Mix 25 ikupezekanso.Insulin Humalog Remix ndi msanganizo wofanana wofanana ndi Lizpro yochepa-insulin solution ndi Lizpro insulin kuyimitsidwa ndi nthawi yayitali.

Insulin Humalog ndi DNA yosinthika ya insulin ya anthu. Chochititsa chidwi ndi kusintha kwa kuphatikiza kwa ma amino acid mu insulin B.

Mankhwala amawongolera njirayi shuga kagayidwe ndipo ali nazo anabolic zotsatira. Zilowetsedwa m'matumba a minofu ya anthu, zomwe zimakulirakulira zimachuluka glycerol, glycogenmafuta acids kumatheka mapuloteni kaphatikizidwe, kumwa ma amino acid kukukula, komabe, kukuchepa gluconeogenesis, ketogenesis, glycogenolysis, lipolysiskumasulidwa ma amino acidndi catabolism mapuloteni.

Ngati alipo shuga 1ndi 2mitundu yandi kumayambiriro kwa mankhwala atatha kudya, kutchulidwa kokwanira hyperglycemiaZokhudza insulin ya munthu. Kutalika kwa Lizpro kumasiyanasiyana ndipo kumatengera zinthu zambiri - mlingo, kutentha kwa thupi, jakisoni, magazi, kuchita masewera olimbitsa thupi.

Makonzedwe a insulin a Lizpro amaphatikizidwa ndi kuchepa kwa ziwonetsero nocturnal hypoglycemia Odwala omwe ali ndi matenda a shuga, ndipo zochita zake poyerekeza ndi insulin ya anthu zimachitika mofulumira (pafupifupi pambuyo mphindi 15) ndipo zimakhala zazifupi (kuyambira maola 2 mpaka 5).

Pambuyo pakukonzekera, mankhwalawa amalowetsedwa mwachangu ndikuyendetsedwa kwambiri m'magazi kumachitika pambuyo pa ½ - 1 ora. Odwala kulephera kwa aimpso kuchuluka kwa mayamwidwe poyerekeza ndi anthu insulin. Hafu ya moyo ili pafupifupi ola limodzi.

Insulin-wodwala matenda a shuga: kulekerera bwino kukonzekera insulin ina, postprandial hyperglycemiakukonza pang'ono ndi mankhwala ena, pachimake insulin kukana,

Matenda a shuga: pa milandu yokana mankhwala a antiidiabetes, machitidwendi matenda ochulukitsa chipatala cha odwala matenda ashuga.

Hypersensitivity mankhwala hypoglycemia.

Hypoglycemia ndiye zotsatira zoyipa chifukwa cha zochita za mankhwala. Angayambitse hypoglycemia hypoglycemic chikomokere (kulephera kudziwa), makamaka, wodwalayo atha kufa.

Thupi lawo siligwirizana: nthawi zambiri mu mawonekedwe a mawonekedwe amderalo - kuyimitsidwa pamalo a jakisoni, redness kapena kutupa, lipodystrophypa jakisoni, jakisoni wambiri yemwe samachitika - kuyabwa kwa khungu, malungo, kuchepa kwa magazi, kuchuluka thukuta, angioedema, kupuma movutikira, tachycardia.

Mlingo wa mankhwalawa umayikidwa payekha kutengera mphamvu ya odwala exo native insulin ndi momwe alili. Ndikulimbikitsidwa kupatsa mankhwala osapitirira mphindi 15 musanadye kapena mutatha kudya. Njira yoyendetsera ntchito ndi payokha. Pochita izi, kutentha kwa mankhwala akhale pamalo oyenera.

Zofunikira zatsiku ndi tsiku zimatha zosiyanasiyana, mpaka nthawi zambiri zimakhala 0.5-1 IU / kg. M'tsogolo, tsiku ndi tsiku Mlingo wa mankhwalawa umasinthidwa malinga ndi momwe wodwalayo amagwirira ntchito ndi zambiri kuchokera pamagazi angapo ndi mkodzo poyeserera shuga.

Intravenous management ya Humalog imachitika ngati muyezo wa jekeseni wovomerezeka. Jakisoni wotsekemera amapangidwa m'apewa, matako, ntchafu kapena pamimba, nthawi ndi nthawi kuwasinthana osaloleza kugwiritsa ntchito malo amodzimodzi kamodzi pamwezi, ndipo malo omwe jakisoniyo sayenera kutenthedwa. Pakati pa njirayi, chisamaliro chimayenera kutengedwa kuti musalowe mumtsempha wamagazi.

Wodwala ayenera kuphunzira njira yolondola ya jakisoni.

Mankhwala osokoneza bongo amatha kuyambitsa hypoglycemiaNdikuphatikizidwa ndi zoopsa, thukuta, kusanza, mphwayikunjenjemera, kusokonezeka kwa chikumbumtima, tachycardiamutu. Nthawi yomweyo, hypoglycemia imatha kuchitika osagwiritsa ntchito mankhwala osokoneza bongo okha, komanso zotsatira zake kuchuluka kwa insulinchifukwa cha mphamvu yamagetsi kapena kudya. Kutengera kuuma kwa hypoglycemia, njira zoyenera zimatengedwa.

Hypoglycemic zotsatira za mankhwala amachepetsa kulera kwamlomo, Mankhwala Osokoneza bongo mahomoni a chithokomiro, GKS, Danazol, beta 2-adrenergic agonists, tridclic antidepressants, okodzetsa, Diazoxide, Isoniazid, Chlorprotixen, lithiamu carbonatezotumphukira phenothiazine, nicotinic acid.

Hypoglycemic zotsatira za mankhwalawa zimatheka anabolic steroids, opanga betamankhwala okhala ndi Mowa Fenfluramine, manzeru, Guanethidine, Mao zoletsa, m`kamwa hypoglycemic mankhwala, salicylates, sulfonamides, ACE zoletsa, Octreotide.

Humalog sikulimbikitsidwa kuti isakanikidwe ndi kukonzekera kwa insulin ya nyama, koma imatha kuyang'aniridwa ndi dokotala wokhala ndi insulin yayitali yaumunthu.

Musazizire m'firiji pa kutentha kwa 2 ° mpaka 8 ° C.

Perekrest S.V., Shainidze K.Z., Korneva E.A. Kachitidwe ka mitsempha yama orexin. Mapangidwe ndi ntchito, ELBI-SPb - M., 2012. - 80 p.
Matenda A shuga, Mankhwala - M., 2016. - 603 c.
Chakudya chomwe chimachiritsa matenda ashuga. - M: Club yazosangalatsa za mabanja, 2011. - 608 c.

Ndiloleni ndidziwitse. Dzina langa ndi Elena. Ndakhala ndikugwira ntchito ya endocrinologist kwa zaka zoposa 10. Ndikukhulupirira kuti pakadali pano ndili katswiri pantchito yanga ndipo ndikufuna kuthandiza alendo onse omwe amapezeka pamalowo kuti athetse zovuta osati ntchito. Zinthu zonse za tsambalo amazisonkhanitsa ndikuzikonza mosamala kuti athe kufotokoza zambiri zofunikira. Musanagwiritse ntchito zomwe zikufotokozedwa pa webusayiti, kukambirana ndi akatswiri ndizofunikira nthawi zonse.