Glucobay: malangizo ntchito mankhwalawa matenda a shuga a 2 osakanikirana ndi mankhwala othandizira

M'nkhaniyi, tikambirana malangizo a "Glucobuy".

Mankhwala ndi mankhwala amkamwa omwe amagwiritsidwa ntchito kwambiri pothandizira matenda a shuga. Kodi ndi matenda amtundu wanji awa?

Type 2 shuga mellitus ndimatenda odziyimira pawokha.

Matenda a 2 a matenda a shuga ndi matenda a endocrine pomwe kuphwanya chidwi cha zochita za insulin kumachitika m'thupi lathu. Kupanga kwakukulu kwa maselo a pancreatic β-omwe amakwiya ndi matendawa kumatha mphamvu za maselo, kupanga insulini kumayamba kuchepa, zomwe zimabweretsa kufunika kwa jakisoni wake. Matendawa nthawi zambiri amayambira zaka 40. Kukhazikika kwa matendawa kumachitika pokhapokha chifukwa cha zovuta zaumoyo komanso sizitengera majini. Odwala ambiri amakhala ndi cholozera chowonjezera cha thupi.

Gulu la matenda

Matendawa ali, malinga ndi gulu la mayiko, mndandanda wake ndi kufotokozera. Khodi ya ICD-10 yodwala matenda ashuga achiwiri idzafotokozeredwa pansipa.

Chifukwa chachikulu chomwe matendawa amalemera kwambiri, chifukwa chake anthu omwe ali ndi vuto lakelo ayenera kuyang'anitsitsa shuga wawo wamagazi. Zizindikiro zoyambirira:

kukodza pafupipafupi
ludzu lalikulupo
njala yosatha.

Ponena za zizindikiro zowonjezera, ndizosintha zosiyanasiyana mthupi zomwe zimachitika chifukwa cha njirayi.

Chithandizo cha matenda a shuga 2 amtundu wodziwikiridwa atazindikira (omwe, mosiyana ndi matenda amtundu wa 1 wodwala, samadalira insulin) imapereka njira zambiri zopangira maphikidwe ndi mankhwala a wowerengeka. Chomwe chikutsimikizidwa kwambiri ndikusintha kwa moyo wanu pankhani ya kadyedwe. Zochita zachipatala zimawonetsa kuti njira zochiritsira izi nthawi zambiri zimapereka zotsatira zabwino ngati wodwala amakwaniritsa zonse zomwe akulimbikitsazo.

Nambala zoperekedwa ziyeneranso kudziwidwa:

Khodi ya ICD-10 yokhala ndi matenda a shuga a 2 ndi E10.
Matenda a shuga omwe amadalira insulin sakhala ndi nambala ya E11.
Code E12 imafotokoza za matenda ashuga, omwe amapezeka chifukwa cha kuperewera kwa zakudya m'thupi (mtundu wa gestational).
Code E14 imatanthawuza zikhalidwe zonse zokhudzana ndi mitundu yosadziwika ya pathological process.

Pharmacological zimatha mankhwala

Monga momwe malangizo a Glucobuy akusonyezera, gawo lomwe limagwiritsa ntchito mankhwalawa ndi acarbose. Izi zimalepheretsa kusintha kwamphamvu kwa sucrose kukhala glucose, komwe kumachepetsa mayamwidwe ake m'magazi kuchokera m'mimba.

Mankhwalawa "Glucobay" amawonetsedwa ndi katswiri wodzipatula pomwe zakudya zapadera zaumoyo sizinapatse zotsatira zoyambitsa matenda. Mankhwalawa amagwiritsidwa ntchito ngati mankhwala a monotherapeutic kapena osakanikirana ndi insulin ndi mankhwala ena a pharmacological.

"Glucobai", kugwiritsa ntchito komwe kumafuna kudya komanso kuchita masewera olimbitsa thupi, ndikugwiritsa ntchito pafupipafupi, kumachepetsa mwayi wokhudzana ndi hypo- ndi hyperglycemia, chiopsezo chotenga myocardial infarction ndi mtima wina matenda opatsirana pamtima. Mphamvu ya yogwira pophika mankhwala amapangidwa chifukwa cha kuchepa kwa magwiritsidwe a alpha-glucosidase komanso kutalikirana kwa nthawi ya mayamwidwe m'magazi. Chifukwa chake, mankhwalawa amachepetsa kuchuluka kwake m'magazi mukatha kudya ndikuchepetsa kusinthasintha kwa tsiku ndi tsiku m'magazi a m'magazi a plasma.

Malinga ndi malangizo a "Glucobuy" mutamwa mankhwalawa pambuyo pa maola 1-2, chitukuko cha nsonga yoyamba ya acarbose chimadziwika. Mtengo wachiwiri umapezeka pamtunda kuyambira maola 14 mpaka 24. Zake bioavailability zimasiyanasiyana pakati 1-2%. Zinthu za metabolic zomwe zimapangidwa ndimankhwala zimapangidwa kudzera m'matumbo - 51% ndi impso - 35%.

Kutulutsa mawonekedwe ndi kapangidwe kake

Mapangidwe a mapiritsi a Glucobai amaphatikiza mankhwala acarbose omwe ali mu Mlingo wa 100 ndi 50 mg, komanso zina zowonjezera: colloidal silicon dioxide, magnesium stearate, starch ya chimanga ndi mapadi.

Mankhwalawa amapangidwa ngati mapiritsi oyera a biconvex ndi mtundu wachikasu wamitundu iwiri, womwe umasiyana ndi zomwe zimathandizira komanso zogwira ntchito. Mbali ina ya ngalawa pali mulingo wa acarbose ndi zolemba zamakampani monga mawonekedwe a mtanda wa Bayer kumbuyo.

Mapiritsi a Glucobay amapakidwa m'matumba 15 ndi m'mabokosi amakatoni. Alumali moyo wa mankhwala 5 zaka.

Mlingo

Monga momwe malangizo a Glucobuy amanenera, mankhwalawa amatengedwa pakamwa, kwathunthu, osatafuna, osambitsidwa ndi madzi pang'ono, asanadye. Mlingo woyenera wa mankhwalawa amasankhidwa kwa wodwala aliyense payekhapayekha.

Monga lamulo, mlingo woyambirira ndi piritsi limodzi la 50 mg kapena theka la piritsi la 100 mg katatu patsiku. Wapakati tsiku lililonse mankhwala ndi 300 mg.

Ngati mankhwalawa ofanana sagwiranso ntchito pambuyo pa masabata 4-8 a chithandizo, tikulimbikitsidwa kuti muonjezere mlingo wa 200 mg katatu pa tsiku. Mlingo wapamwamba ndi 600 mg. Odwala okalamba (zaka zopitilira 65), kusintha kwa myezo kapena mankhwala a dost sikofunikira. Mwa anthu omwe ali ndi vuto la chiwindi, palibe chifukwa chosinthira njira.

Zotsatira zoyipa

Mukamagwiritsa ntchito mankhwala amakonzekera "Glucobay", zotsatira zoyipa zimachitika. Izi zikuphatikiza:

Kuchokera pamatumbo: kutsekula m'mimba, kuphwanya thupi, kupweteka kwa epigastrium, nseru, kuwonjezeka kwa kuchuluka kwa michere ya chiwindi (kangapo), yomwe imazimiririka pambuyo posiya mankhwala, kutsekeka kwamatumbo, jaundice kapena hepatitis, komanso kuwonongeka kwa minyewa ya chiwindi yomwe imakhudzana ndi matenda. Nkhani zokhazokha za chitukuko cha chiwindi chokwanira ndi zotsatira zoyipa zinaonedwa, koma ubale wa milandu yotereyi ndi kayendetsedwe ka acarbose sunafotokozedwe bwino.
Mawonekedwe a thupi lawo: zotupa za pakhungu, urticaria, hyperemia, exanthema.
Mavuto ena obisika mthupi: kutupa.

Contraindication

Mankhwala "Glucobay" (analogues adzawonetsedwa kumapeto kwa nkhaniyo) akuphatikizidwa kuti mugwiritse ntchito potsatira zotsatirazi:

Matenda am'mimba a chamoyo chachilengedwe, omwe amapezeka ndi kusokonezeka kwakukulu komwe kumayamwa michere ndi kuphwanya kwa magawo ambiri pakudya,
zovuta zomwe zimatha kutsatiridwa ndi kumachitika mwaulemu (ma hernias akuluakulu amtundu uliwonse, Remkheld's syndrome, zilonda zam'mimba, zotsekeka m'matumbo),
kulephera kwakukulu kwa aimpso (ndi CC December 6, 2018

Momwe mungamwe mapiritsi Glucofage pakuchepetsa thupi - malangizo, ntchito, ndemanga

Pazonse, Glucophage ndi piritsi yomwe imalembedwa mtundu wachiwiri wa matenda ashuga. Koma azimayi omwe amafunafuna mawonekedwe abwino nthawi zambiri samakhala wokondwa chifukwa chogwiritsira ntchito mankhwala apadera.

Ndipo amayamba kugwiritsa ntchito polimbana ndi mapaundi owonjezera pazinthu zonse zovomerezeka ndi zosavomerezeka zomwe amaziwona m'mafakitore. Chifukwa chake Glucophage yakuchepetsa thupi yakhala ikugwiritsidwa ntchito pafupipafupi.

Kodi ndichifukwa choti dzina la mankhwalawo limakhala ndi tanthauzo lakusintha ("odya mafuta"), kapena kuti limathandizadi? Ndipo ngati zingathandize, ndiye bwanji?

Kodi glucophage imagwirizana bwanji ndi kuchepa thupi?

Monga tanena kale, mankhwalawa Glucophage adapangidwa kuti azithandiza odwala matenda ashuga. Chofunikira chake chachikulu, metformin, chimachepetsa shuga.

Koma "mbali" yakuthengo ndi kuwotcha kwamafuta amthupi. Ichi ndichifukwa chake mapiritsi ndi anthu onenepa kwambiri adazikonda ndi izi (mwa njira, pakati pa odwala matenda ashuga nawonso, izi zimachitika kawirikawiri).

Chifukwa chake, Nazi zabwino zake za mankhwalawa zomwe zimathandiza kuthana ndi kunenepa kwambiri:

kubwezeretsanso kwa matenda a lipid metabolism,
Kuchepetsa kuwonongeka kwa chakudya cham'madzi ndipo, motero, kusintha kwa maselo amafuta,
malamulo a shuga ndi cholesterol yoyipa m'magazi,
kuponderezana kwachilengedwe kwa kulakalaka (makamaka, kuchepa kwa chidwi cha maswiti) chifukwa cha kuphatikiza kwa kupanga kwa insulin.

Pali zoyerekeza zingapo za Glucofage, ndipo ambiri aiwo amadziwa kwa iwo omwe akuyesera kukonza njira yochepetsera thupi. Choyamba, izi ndi mankhwala monga Siofor ndi Metformin. Chofunikira chachikulu cha mapiritsi a shuga imapezekanso ku Bagomet, Glycon, Metospanin, Gliminfor, Glformin, Langerin, Formetin, Metadiene, ndi zina zambiri.

Malangizo ogwiritsira ntchito Glucofage

Chinthu choyamba chomwe muyenera kukumana nacho ndikusintha zakudya zanu ndi zochita zanu tsiku ndi tsiku. Zakudya mukamamwa Glucofage sizofunikira, koma zofunika. Ndipo, ayenera kukumana ndi mavuto otani:

kusiyanitsidwa ndi zakudya za zakudya zomwe zimapangitsa shuga m'magazi,
kukana kudya kwamphamvu chakudya (ngakhale tinthu tating'onoting'ono titha kupewetsa mphamvu yonse ya mapiritsi),
kupatsa thanzi kwa zakudya zomwe zimakhala ndi fiber (nyemba, mafuta opaka, masamba).

Sankhani nokha zakudya zamagulu ochepa zopatsa mphamvu (1800 kcal patsiku) ndipo gwiritsitsani menyu yake osapatuka. Koma izi sizovuta zonse. Muyenera kusiya zakumwa zilizonse zomwe zili ndi mowa. Kusuta, mwanjira, kumachepetsa kwambiri phindu la metformin.

Nthawi yomweyo, zolimbitsa thupi ziyenera kuchuluka. Mwa njira, mpaka posachedwapa, ankakhulupirira kuti kuchepa thupi ndi Glucofage ndi masewera sikugwirizana - akuti, kuchuluka kwa acid m'magazi panthawi yophunzitsira kumachepetsa mphamvu ya mankhwalawa. Koma kafukufuku waposachedwa atsutsa kukayikira kumeneku. Komanso, zinadziwika kuti moyo wokangalika uthandizira kupititsa patsogolo njira yochepetsera thupi.

Glucophage imapezeka m'mapiritsi a 500, 850 ndi 1000 mg. Kuchepetsa thupi, mankhwalawa amatengedwa 500 mg katatu patsiku ola limodzi asanadye. Kutalika kwa maphunzirowa sikupitilira masiku 18-20. Pambuyo pa izi, yopuma ya miyezi iwiri iyenera kupangidwa - izi ndizofunikira kuti Metformin iwonetsere kwathunthu mafuta ake omwe amawotcha mafuta.

Glucophage - contraindication ndi mavuto

Metformin, ngati simukuphwanya malangizo ogwiritsira ntchito, sikuyenera kukhala ndi vuto lililonse paumoyo. Ndipo izi zidatsimikiziridwa ndi kafukufuku wobwereza wazaka. Koma contraindication mwachindunji kuti atenge Glucophage, komabe, ilipo. Ndipo kuwanyalanyaza kungakhale kupanda nzeru kwenikweni. Nazi izi:

mtundu 1 shuga
mimba, yoyamwitsa,
nthawi yogwira ntchito komanso yodziwitsa ena,
matenda a mtima
Kulephera kwaimpso ndi matenda ena a impso,
uchidakwa.

Zotsatira zoyipa zomwe nthawi zina zimatsagana ndi Glucophage ndizofanana m'njira zambiri ndi zomwe zimayambitsa poizoni. Mutu, nseru, kusanza kumachitika, kupangika kwa mpweya, kutsekula m'mimba, lactic acidosis imayamba, kutentha kwa thupi kumatuluka, colic yamatumbo ndi kufooka kwakukulu kumawonedwa.

Monga lamulo, zochitika zimachitika kumayambiriro kwa maphunzirowa ndipo zimagwirizanitsidwa ndi mankhwala osokoneza bongo, kapenanso ndimatenda osapatsa thanzi (chakudya chamagulu owonjezera). Mavuto oterewa akachitika, sinthani mlingo wa mankhwalawo. Ngati palibe kusintha, pitani kuchipatala msanga.

Ndemanga za Glucofage

Yana, wazaka 28. Ndakhala ndikutenga Glucophage kwa milungu itatu tsopano - zotsatira zake ndi ziro. Ndipo, chodabwitsa kwambiri, ndikufuna kudya zamadzulo madzulo. Sindingathe kudzithandiza ndekha. Zosangalatsa, kodi iye akungondichita zolakwika?

Galina, wazaka 30. Kuwona Glucofage kwa miyezi 6 (kutenga miyezi 1.5 yopuma). Ndidafunitsitsadi kuchepetsa thupi, koma ndinali ndi chidwi chofuna kudya - kukhala wathanzi. Pakhala zochepa, koma pazifukwa zina sizinachepetse thupi.

Komanso, mavuto ndi chikhodzodzo, adayamba, ma pustule ena adawoneka pa thupi. Mwambiri, adaponya mapiritsi, adayamba kutsatira zakudya zopatsa thanzi. Ndipo izi zokha ndizomwe zidandithandiza kutaya 25 kg pa chaka.

Ndipo sindilangiza aliyense kuti atenge Glucophage.

Margarita, wazaka 34. Metformin sikugwiranso ntchito kwa ine, koma kumva njala kumatha, chifukwa ndinayenera kusiya maukonde omwe ndimawakonda. Ndimapirira china chake kwa milungu itatu. Komabe, zotsatira zake zikadakhala, koma sanali - adataya mphamvu 1 kg.

Olesya, wazaka 26. Ndipo endocrinologist adandiuza kuti Glucofage - tsitsi langa lidayamba kugwa kwambiri nditabadwa. Ndakhala ndikumwa kwa masiku khumi - mkhalidwe wolephera: nseru, chizungulire, kutsekula m'mimba. Mwa njira, chifukwa chomaliza, ndataya kale 3 makilogalamu, ngakhale kuchepetsa thupi sicholinga changa. Tsopano ndichepetsa mlingo wake, monga momwe zalembedwera pano, zitha kumvanso bwino.

Irina, wazaka 31. Sindinamwa ndekha, koma ndidawona zotsatira zoonekera za kuchepetsa thupi. Mnansi wanga amamwa Glyukofazh pa 1000 mg kawiri patsiku ndipo wataya kale 13 kg. Ndiyesanso ndikangosiya kusuta.

Svetlana, wazaka 30. Pa maphunziro amodzi a Glucophage, ndidataya makilogalamu 8. Zinali zosavuta - kutsegula m'mimba, kunyansidwa, kufooka ... Munthawi imeneyi, sindingathe kuchita nawo aerobics. Koma kenako zonse zidapita. Chifukwa chake sizinali pachabe kuti anali kuzunzidwa - anangokhoza kukhala bwino nyengo yakunyanja.

Acarbose, silica anhydrous colloidal, magnesium stearate, chimanga wowuma, cellcrystalline cellulose.

Mankhwala

Hypoglycemic mankhwala inhibitor alpha glucosidase. Acarbose- chachikulu yogwira mankhwala chimakhudzana pseudotetrasaccharides magwero achilengedwe.

Mphamvu ya machitidwe amachokera pakukakamiza kwa ntchito alpha glucosidase (enzyme ya m'mimba yaying'ono) yomwe imasweka saccharides, zomwe zimapangitsa kuti muchepetse zakudya zomwe zimapangitsa kuti mu chakudya muzikhala chakudya pang'ono komanso kuti muchepetse mayendedwe omasulidwa shugazopangidwa munthawi yakusokonekera kwa chakudya. Ndiye kuti, acarbose Kuchedwa ndi kuchepetsa ndende shuga m'magazi. Zotsatira zake, shuga amapezeka m'matumbo moyenera, ndipo kusinthasintha kwake m'magazi tsiku lonse kumachepetsedwa.

Pharmacokinetics

Mankhwalawa amayamba pang'ono pang'onopang'ono kuchokera Matumbo. Mitu iwiri yapadera imadziwika Cmaxacarbose m'magazi. Woyamba pambuyo pa maola 1-2 ndipo wachiwiri utatha maola 16-24. The bioavailability wa mankhwala pafupifupi 1-2%. Amayamwa m'matumbo (51%) komanso impso (35%) makamaka mwa ma metabolites.

Glucobay, malangizo ogwiritsira ntchito (Njira ndi Mlingo)

Mankhwalawa amagwira ntchito limodzi mukamadyedwa musanadye kaye ndi chakudya choyamba. Nthawi yomweyo mapiritsi amayenera kumwa onse, kutsukidwa ndi madzi. Mlingo wa mankhwalawa kwa wodwala aliyense ndiwofanana.

Pafupifupi odwala matenda ashuga Mitundu iwiri, mlingo woyambirira ndi 50 mg katatu pa tsiku. Kumwa mankhwalawa kumaphatikizidwa ndi zakudya zapadera.

Ngati ndi kotheka, ngati palibe achire zotsatira zake, muyezowo utha kuwonjezeka mpaka 300 mg patsiku.

Odwala ndi kulephera kwa aimpso ndikusintha kwakatalika kwa mankhwala sikofunikira. Kugwiritsa ntchito Glucoboy kuyenera kuchitika motsutsana ndi maziko azakudya za okhwima. Simungathetse mankhwalawo nokha, chifukwa izi zimapangitsa kuti shuga wamagazi awonjezeke. Ndi kuwonjezeka kwamtundu wosiyanasiyana wam'matumbo, ndikofunikira kuchepetsa mlingo wa mankhwalawa.

Glucobay exposition

Acarbose ndi cholepheretsa ma amylases - gulu la ma enzymes omwe amachititsa kuti maselo azovuta a carbohydrate akhale osavuta, chifukwa thupi lathu limatha kuyamwa monosaccharides (glucose, fructose, sucrose). Njirayi imayamba mkamwa (imakhala ndi ma amylase ake), koma njira yayikulu imapezeka m'matumbo.

Glucobai, kulowa m'matumbo, imalepheretsa kuphatika kwa mafuta ochulukitsa am'molekyulu, kotero mafuta omwe amalowa mthupi ndi chakudya sangathe kumizidwa kwathunthu.

Mankhwalawa amagwira ntchito kwanuko, makamaka m'matumbo a lumen. Simalowa m'magazi ndipo sizikhudza ntchito ya ziwalo ndi machitidwe (kuphatikiza kupanga insulin, kupanga shuga m'magazi).

Mankhwala ndi oligosaccharide - nayonso mphamvu mankhwala aorganorganism Actinoplanes utahensis. Ntchito zake zimaphatikizapo kutsekereza cy-glucosidase, enzyme ya pancreatic yomwe imagwetsa zovuta zam'mimba kukhala mamolekyulu osavuta. Mwa kuletsa kuyamwa kwa zovuta zamankhwala, Acarbose amathandizira kuthetsa shuga wambiri ndikupangitsa matenda a glycemia kuchepa.

Popeza mankhwalawa amachepetsa kuyamwa, amangogwira ntchito mukatha kudya.

Ndipo popeza sizikulimbikitsa maselo a "responsible-cell" omwe amapanga ndi kubisala kwa insulin ya amkati, Glucobai siyonso imayambitsa matenda a glycemic.

Yemwe amawonetsedwa ngati mankhwalawo

Kuchepetsa kwa shuga kwa mankhwalawa sikunatchulidwe monga kwa hypoglycemic analogues, chifukwa chake, sizothandiza kugwiritsa ntchito mankhwalawa ngati monotherapy. Nthawi zambiri imafotokozedwa ngati chothandiza, osati pa mitundu yonse ya matenda a shuga okha, komanso pamikhalidwe ya prediabetes: kusala kwa vuto la glycemia, kusintha kwa kulolerana kwa shuga.

Momwe mungamwere mankhwala

Mu pharmac unyolo Acarbose, mutha kupeza mitundu iwiri: ndi mlingo wa 50 ndi 100 mg. Mlingo woyambira wa Glucobay, mogwirizana ndi malangizo ogwiritsira ntchito, 50 mg / tsiku. Sabata lililonse, posakwanira, mutha kutumiza mapiritsi a kuchuluka kwa 50 mg, ndikugawa mapiritsi onse muyezo waukulu. Ngati mankhwalawa amalekeredwa bwino ndi odwala matenda ashuga (ndipo pali zovuta zokwanira zosayembekezereka), ndiye kuti mankhwalawa amatha kusintha mpaka 3 r. / Tsiku. 100 mg aliyense. Muyezo wapamwamba kwambiri wa Glucobay ndi 300 mg / tsiku.

Amamwa mankhwalawo asanadye kapena ali mkati mwake, akumwa piritsi lonse ndi madzi. Nthawi zina madokotala amalangiza kutafuna mapiritsi ndi supuni yoyamba ya chakudya.

Ntchito yayikulu ndikupereka mankhwalawa mukuwunikira m'matumbo ang'onoang'ono, kotero kuti pofika nthawi yodya mafuta, anali wokonzeka kugwira nawo ntchito.

Ngati menyu mukadakhala kuti mulibe zakudya zamafuta (mazira, tchizi tchizi, nsomba, nyama yopanda buledi ndi mbale zokhala ndi wowuma), mutha kudumpha ndikumwa mapiritsi. Acarbose sagwira ntchito pankhani yogwiritsira ntchito monosaccharides yosavuta - shuga wowona, fructose.

Mphamvu ya antihyperglycemic ya Glucobay imakhala yofooka, kotero nthawi zambiri imayikidwa ngati chida chowonjezera pakugwiritsira ntchito zovuta mankhwala. Monga tanena kale, mankhwalawo pawokha samayambitsa hypoglycemia, koma mu zovuta zovuta pamankhwala ena a hypoglycemic, zotere zimatheka. Amaletsa kuukiridwa osati ndi shuga, monga zimakhalira nthawi zina, - wozunzidwayo amayenera kupatsidwa chakudya chochepa cham'mimba, chomwe ma acarbose amakumana.

Zotsatira zoyipa

Popeza acarbose imalepheretsa kuyamwa kwa chakudya cham'madzi, chomaliza chimadziunjikira m'matumbo ndikuyamba kupatsa mphamvu. Zizindikiro za kupsya mtima zimawoneka mu mawonekedwe akukulira kwa kupanga kwa gasi, kugwedezeka, kuyimba muluzi, kumatulutsa, kupweteka m'derali, kutsegula m'mimba. Zotsatira zake, wodwala matendawa amaopa ngakhale kutuluka mnyumbamo, chifukwa vuto losalamulirika limasokoneza chikhalidwe.

Kusavutikako kumakulirakudya pambuyo pakupeza zakudya zamafuta ochulukirapo, makamaka mashuga, m'matumbo am'mimba ndipo amachepetsa ngati chakudya chamafuta pang'ono. Glucobai imagwira ntchito ngati mtundu wa mafuta ochulukirapo, ikukhazikitsa malire ake pazopezeka zamtunduwu. Zomwe gawo lililonse limachita palokha, sipangakhale kusinthika kokwanira m'mimba ngati mungayang'anire zakudya zanu komanso kunenepa.

Kuphatikiza pa α-glucosidase, mankhwalawa amalepheretsa kugwira ntchito kwa lactase, enzyme yomwe imaphwanya shuga ya mkaka ndi 10%. Ngati munthu wodwala matenda ashuga ataona kale kuchepa kwa ntchito ya enzyme, tsankho la mkaka (makamaka mkaka ndi mkaka) zimathandizira izi. Zinthu zamkaka nthawi zambiri zimakhala zosavuta kugaya.

Nthawi zambiri vuto la kusowa kwa magazi ndilomwe thupi limachita ndipo khungu limatupa.

Monga mankhwala opangira ambiri, imatha kukhala totupa pakhungu, kuyabwa, redness, nthawi zina - ngakhale edema ya Quincke.

Contraindication ndi analogues a acarbose

Osakulemberani Glucobai:

Odwala odwala matenda amitsempha
Ndi zilonda zam'mimba,
Panthawi yotupa kwamatumbo (mu mawonekedwe owopsa kapena aakulu),
Anthu odwala matenda ashuga ndi hernia (inguinal, femal, umbilical, epigastric),
Amayi oyembekezera komanso oyembekezera
Ndi malabsorption syndrome,
odwala matenda a impso.

Pali ma fanizo ochepa a Glucobay: malinga ndi gawo lomwe limagwira (acarbose), lingasinthidwe ndi Alumina, komanso ndi chithandizo chamankhwala - ndi Vox.

Glucobay yochepetsa thupi

Ambiri mwa anthu padziko lapansi sakusangalala ndi kulemera kwawo komanso kuchuluka kwawo. Kodi ndizotheka kuletsa mayamwidwe am'madzi muopanda matenda ashuga ngati ndachimwa ndikudya? Omanga thupi amalangizidwa kuti "achotse keke kapena kumwa piritsi la Glucobay." Imalepheretsa ma pancreatic amylases, gulu la ma enzyme omwe amawononga ma polysaccharides kukhala ma analogi a mono. Chilichonse chomwe matumbo sanamwe, amadzipangira okha madzi, ndikuwotchera m'mimba.

Ndipo malingaliro ofunikira: ngati simungathe kudzikonzera nokha maswiti ndi makeke, idyani mapiritsi amodzi kapena awiri a Acarbose (50-100 mg) musanamwe mlingo wotsatira wa chakudya. Ngati mukuwona kuti mukudya kwambiri, mutha kumeza piritsi lina la 50 mg. Kutsegula m'mimba ndi mazunzo a "zakudya" izi, koma sikuwongolera monga kutaya thupi, mwachitsanzo, ndi orlistat.

Ndiye kodi ndichabwino "kuzolowera chemistry" ngati mutha kuyambiranso zakudya zopanda pake pambuyo pa phwando lokondwerera? Gala Ref Refx idzapangidwa pakatha mwezi umodzi, ndipo mudzawongolera mwayi uliwonse, ngakhale wopanda madzi ndi zala ziwiri. Ndizovuta komanso okwera mtengo kuthana ndi ma pathologies amenewo, chifukwa chake ndikosavuta kugwiritsa ntchito matumbo kuti muchepetse kunenepa.

Glucobay - ndemanga za anthu odwala matenda ashuga

Ndiye kodi ndiyofunika kapena siyabwino kumwa Glucobai? Tiyeni tiyambe ndi zabwino zopanda malire:

Mankhwalawa samamwetsedwa m'magazi ndipo alibe mphamvu m'thupi.
Simalimbikitsa kaphatikizidwe ndi insulin yakeyo, motero palibe hypoglycemia pazotsatira zoyipa.
Zinakhazikitsidwa poyesa kuti kugwiritsa ntchito acarbose nthawi yayitali kumachepetsa kwambiri cholesterol "yoyipa" komanso kuchuluka kwa atherosulinosis wodwala matenda ashuga,
Kuletsa kuyamwa kwa mafuta kumathandiza kuti muchepetse kunenepa.

Pali zovuta zochepa: kugwira ntchito molakwika ndi kusayenerera kwa monotherapy, komanso kutchulidwa koyipa mwanjira yamavuto a dyspeptic, omwe amathandizira kuchepetsa kunenepa ndi kudya.

Kuchita

Kugwiritsidwa ntchito mosiyanasiyana kwa Glucobai ndi zakudya zopatsa mpweya kwambiri kungayambitse kutsegula m'mimba ndi chisangalalo.

Ndi munthawi yomweyo mankhwala a matumbo adsorbents, cholesterol, Mankhwala okhala ndi michere yokumba, mphamvu ya Glucobay imachepetsedwa. Glucobai imatha kusintha bioavailability digoxin.

Kulimbikitsa mphamvu ya Hypoglycemic ya mankhwalawa kumatha kuchitika limodzi metforminzotumphukira sulfonylureas, insulin.

Mankhwala omwe amayambitsa hyperglycemia (glucocorticosteroids, okodzetsa, estrogens, njira zakulera zamkamwa, phenothiazine, isoniazid, phenytoin, mahomoni a chithokomiro, nicotinic acid, adrenostimulants) amachepetsa kwambiri ntchito ya Glucobay.

Ndemanga za Glucobaya

Ndemanga ya mankhwala ambiri mwa odwala ndiabwino. Komabe, munthu sayenera kuyiwala kuti ntchito yake imatsimikiziridwa ndi mlingo woyenera komanso kuvomerezera kudya motsutsana ndi maziko a chithandizo cha mankhwala.

Alendo ambiri opezeka pazowonda zolemetsa amafunsa funso kuti: Kodi ndingagwiritse ntchito mankhwalawa Glucobay kuti muchepetse thupi? Tengani mankhwalawa kuti muchepetse kunenepa osavomerezeka.

Gwiritsani ntchito zida zapadera kuti muchite izi.

Mtengo wa Glucobay, komwe mugule

Mtengo wa mapiritsi a Glucobaya umasiyana pakati pa 360 - 420 rubles pakiti iliyonse. Mutha kugula Glucobay m'masitolo ogulitsa mankhwala ku Moscow ndi m'mizinda ina popanda zovuta.

Mankhwala ogulitsa pa intaneti ku Russia
Mankhwala ogulitsa pa intaneti ku Kazakhstan

Glucobai mapiritsi 50 mg 30 pcs Bayer
Glucobai mapiritsi 100 mg 30 pcs Bayer

Glucobai 50mg No. 30 mapiritsi Bayer Schering Pharma AG
Glucobai 100mg No. 30 mapiritsi Bayer Schering Pharma AG

Mankhwala IFC

Glucobai 100 mg No. 30 tabu.

LAPANI ZOTSATIRA! Zambiri pamankhwala omwe ali pamalowo ndizokhudza zonse, zomwe zimatengedwa kuchokera kwa anthu ndipo sizingagwiritsidwe ntchito ngati lingaliro la kugwiritsa ntchito mankhwalawa munthawi ya chithandizo. Musanagwiritse ntchito mankhwala Glucobai, onetsetsani kuonana ndi dokotala.

Acarbose - mawonekedwe ogwiritsira ntchito: katundu ndi kuchitapo kanthu, mtengo wake ndi analogi ya glucobai, ndemanga zakuyamwa

Mankhwala ena opangidwa pofuna kuchiza matenda ashuga amatchulidwa ngati njira yochepetsera thupi. Mankhwala othandizira pakudya amatha kuchitika limodzi ndi mapiritsi okhala ndi zinthu monga acarbose, chifukwa choti kugaya chakudya mwachangu ndi chimbudzi cha michere kumachitika, hyperglycemia, ndiye kuti, shuga wamagazi ambiri.

Kodi acarbose ndi chiyani

Mankhwalawa ali ndi katundu wa hypoglycemic, chifukwa chomwe chimbudzi ndi mayamwidwe am'mimba ndi matumbo ochepa amakhala oletsedwa.

Chifukwa cha izi, glucose omwe ali m'magazi amatsitsidwa, omwe pamapeto pake amachititsa kuti achepetse kunenepa kwambiri.

Acarbose amalembedwa kwa anthu odwala matenda ashuga ngati mankhwala ena a hypoglycemic osagwira ntchito moyenera ndi chithandizo chowonjezera chofunikira.

Acarbose ndi mankhwala ochokera ku gulu la oligosaccharides (conjugates, polysaccharides), ufa wopepuka womwe umasungunuka mofulumira m'madzi. Zomwe zimagwiritsidwa ntchito zimapezeka kuchokera kuma tizilombo tating'onoting'ono Actinoplanes utahensis pogwiritsa ntchito nayonso mphamvu, ndipo kulemera kwake ndi 645.6 g pa mamolekyulu. Kuti zithetsedwe kwathunthu ndi thunthu, malovu ndi kapamba ndizofunikira.

Zizindikiro zogwiritsidwa ntchito

Mankhwala ovuta mtundu 2 shuga pamodzi ndi zakudya.

Contraindication

Adalengeza kulephera kwa aimpsomatenda Matumbom'mimba kwambiri ndi mayamwidwe, mimba, wazaka zapakati pa 18, kukhudzidwa kwambiri ndi mankhwalawa, mikhalidwe yotsatira chisangalalo (hernias, zilonda zam'mimbamatumbo kutsekereza). Gwiritsani ntchito mosamala odwala malungo, kuvulala, matenda opatsirana, kulowererapo kwakukulu.

Zotsatira zoyipa

Nthawi zambiri zimawonekera chisangalalokupweteka m'mimba kutsegula m'mimba, kawirikawiri - nseru, wamba thupi lawo siligwirizana, matumbo komanso matumbo.

Glucobay, malangizo ogwiritsira ntchito (Njira ndi Mlingo)

Pafupifupi odwala matenda ashuga Mitundu iwiri, mlingo woyambirira ndi 50 mg katatu pa tsiku. Kumwa mankhwalawa kumaphatikizidwa ndi zakudya zapadera.

Ngati ndi kotheka, ngati palibe achire zotsatira zake, muyezowo utha kuwonjezeka mpaka 300 mg patsiku.

Bongo

Mukumwa Mlingo wambiri kuposa mankhwala othandizira kapena zakumwa zam'mimba, mankhwala osokoneza bongo amawonekera ndi mawonekedwe a chisangalalo ndi kutsegula m'mimba.

Kuchita

Kugwiritsidwa ntchito mosiyanasiyana kwa Glucobai ndi zakudya zopatsa mpweya kwambiri kungayambitse kutsegula m'mimba ndi chisangalalo.

Ndi munthawi yomweyo mankhwala a matumbo adsorbents, cholesterol, Mankhwala okhala ndi michere yokumba, mphamvu ya Glucobay imachepetsedwa. Glucobai imatha kusintha bioavailability digoxin.

Kulimbikitsa mphamvu ya Hypoglycemic ya mankhwalawa kumatha kuchitika limodzi metforminzotumphukira sulfonylureas, insulin.

Malonda ogulitsa

Malo osungira

Kutentha kwa 10 - 25 ° C.

Tsiku lotha ntchito

Ma analogi a Glucobaya

Mankhwala omwe ali ndi vuto lofanananso ndi mankhwalawa amaphatikizapo: Alumina, Siofor, Acarbose.

Ndemanga za Glucobaya

Alendo ambiri opezeka pazowonda zolemetsa amafunsa funso kuti: Kodi ndingagwiritse ntchito mankhwalawa Glucobay kuti muchepetse thupi? Tengani mankhwalawa kuti muchepetse kunenepa osavomerezeka.

Gwiritsani ntchito zida zapadera kuti muchite izi.

Mtengo wa Glucobay, komwe mugule

Mtengo wa mapiritsi a Glucobaya umasiyana pakati pa 360 - 420 rubles pakiti iliyonse. Mutha kugula Glucobay m'masitolo ogulitsa mankhwala ku Moscow ndi m'mizinda ina popanda zovuta.

Mankhwala ogulitsa pa intaneti ku Russia
Mankhwala ogulitsa pa intaneti ku Kazakhstan

Glucobai mapiritsi 50 mg 30 pcs Bayer
Glucobai mapiritsi 100 mg 30 pcs Bayer

Glucobai 50mg No. 30 mapiritsi Bayer Schering Pharma AG
Glucobai 100mg No. 30 mapiritsi Bayer Schering Pharma AG

Mankhwala IFC

Glucobai 100 mg No. 30 tabu.

Acarbose - mawonekedwe ogwiritsira ntchito: katundu ndi kuchitapo kanthu, mtengo wake ndi analogi ya glucobai, ndemanga zakuyamwa

Kodi acarbose ndi chiyani

Mankhwalawa ali ndi katundu wa hypoglycemic, chifukwa chomwe chimbudzi ndi mayamwidwe am'mimba ndi matumbo ochepa amakhala oletsedwa.

Chifukwa cha izi, glucose omwe ali m'magazi amatsitsidwa, omwe pamapeto pake amachititsa kuti achepetse kunenepa kwambiri.

Acarbose amalembedwa kwa anthu odwala matenda ashuga ngati mankhwala ena a hypoglycemic osagwira ntchito moyenera ndi chithandizo chowonjezera chofunikira.

Acarbose ndi mankhwala ochokera ku gulu la oligosaccharides (conjugates, polysaccharides), ufa wopepuka womwe umasungunuka mofulumira m'madzi. Zomwe zimagwiritsidwa ntchito zimapezeka kuchokera ku tizilombo tosiyanasiyana Actinoplanes utahensis wogwiritsa ntchito kupesa, ndipo kulemera kwake ndi 645.6 g pa mamolekyulu.Kuti zithetsedwe kwathunthu ndi thunthu, malovu ndi kapamba ndizofunikira.

Kutulutsa Fomu

Acarbose amagulitsidwa muma pharmacies mu mawonekedwe a mapiritsi a Glucobai 50 kapena 100 mg. Mapiritsiwo ndi oyera ndi tishe wachikasu, oblong, biconvex, wokhala ndi chiopsezo mbali zonse ziwiri. Ndikofunikira kudziwa kuti mbali imodzi iyenera kukhala kulembakuwonetsa kuchuluka kwa 50 kapena 100 mg. Mapiritsi amagulitsidwa m'matumba a 30 ma PC: M'makatoni awiri matuza a 15 ma PC.

Pharmacodynamics ndi pharmacokinetics

Pa mankhwala ndi mankhwalawa, ma hydrolysis zimachitika zimawonetsedwa ndi mpikisano zoletsa (zoletsa) za michere - kapamba wa alpha-amylase ndi matumbo membrane womangidwa alpha-glucosidases.

Chifukwa cha izi, njira zomwe zimapangidwa ndikupanga shuga m'matumbo amachepetsedwa. Pankhaniyi, mankhwalawa samatsogolera ku hypoglycemia ndipo samalimbikitsa kuonjezera kwa insulin.

Nthawi pafupipafupi kumwa mankhwalawa, kuchepa kwa ngozi kumachitika.

mtundu 2 shuga
myocardial infaration
matenda ena a mtima.

Kuyamwa kwa mankhwalawa kuli pafupifupi 35%, pomwe bioavailability wake watsala pafupifupi 1-2%. Mulingo wokwanira wa chinthu m'thupi umawonedwa ola limodzi ndi theka pambuyo pa makonzedwe.

Mankhwalawa zimaphatikizidwa m'migawo ya m'mimba ndikugawana ma enzymes, pomwe thunthu limakhala ndi metabolites pafupifupi 13 - zomwe zimachokera ku 4-methylpyrogallol.

Zizindikiro zogwiritsidwa ntchito

Mankhwala amathandizidwa ndi madokotala pozindikira mtundu wachiwiri wa matenda a shuga wokhudzana ndi matenda osokoneza bongo. Kuphatikiza apo, mankhwalawa atha kutumikiridwa ndi kuperewera kwa mankhwala osakanikirana ndi sulfonylureas, mankhwalawa amaphatikizidwa ndi zakudya zochepa zopatsa mphamvu. Ndikofunika kuti muzisungira kuchuluka kwa shuga anu pafupipafupi maziko.

Phukusi lililonse lomwe lili ndi mapiritsi lili ndi malangizo omwe mungatengere mankhwalawo. Akuluakulu amalimbikitsidwa 25 mg katatu patsiku.

Kuwonjezeka kwa mlingo wokhawo womwe angathe kuperekedwa ndi dokotala pambuyo pakupuma kwa mwezi umodzi. Wachikulire yemwe amalemera mpaka 60 kg ayenera kumwa 50 mg tsiku lililonse.

Ndi thupi loposa 60 kg, mulingo uyenera kuchuluka kawiri, kumwa mankhwalawa kutengera zinthu ziwiri:

ngati pali kuchuluka kwa shuga m'magazi ola limodzi mukatha kudya,
kulolerana kwamunthu kumadziwika.

Kuchepetsa Acarbose

Mankhwalawa amathandizidwanso kwa iwo omwe akufuna kuchepa thupi. Mukamatsatira malangizo onse molondola, ndiye kuti kumwa mapiritsiwo sikutenga nthawi yayitali. Zomwe zikuchitika:

chifukwa cha kuwonongeka kwa chakudya chamafuta, thupi limatsika kuchoka pa 5 kg pa sabata,
kuchuluka kwa shuga m'magazi kumakhazikika,
chiopsezo cha matenda a shuga amachepa.

Mapiritsi okhala ndi acarbose amagulitsidwa pansi pa dzina la Glucobay.

Kugwiritsa ntchito kuchepetsa thupi kumakhazikitsidwa chifukwa kumalepheretsa kuyamwa kwa pafupifupi mafuta onse omwe amabwera kuchokera ku chakudya, kumangotsala mapuloteni okha, chifukwa chake ndizotheka kuchepetsa thupi mofulumira.

Gwero lalikulu lamagetsi ndi kapangidwe kazinthu ka minofu imangokhala kokha mapuloteniChifukwa chake, chiopsezo chotaya chimachepetsedwa kwambiri.

Ndikofunika kulingalira kuti kumwa mankhwala okha osadyetsa sikungapereke zotsatira zomwe zimafunidwa, ndipo chifukwa chovutitsidwa ndi carbohydrate, mwayi wazotsatira zoyipa umakulanso.

Mbali yodziwika bwino ya mankhwalawa ndi nthawi yayitali yochotsa, yomwe imatha kufikira maola 10, kotero imagwira ntchito pafupifupi tsiku lonse.

Amachotseredwa ndi impso kwathunthu atatha maola 12-14.

Malangizo apadera

Munthawi ya mankhwala ndi mankhwalawa, ndikofunikira kutsatira mosamalitsa malangizo onse a madokotala omwe amapezekapo, apo ayi kugwiritsa ntchito mapiritsi sikungakuthandizeni.

Ndikofunikira kuti muchepetse kumwa kwanu zakumwa ndi zakudya zomwe zimakhala ndi shuga ndi zakudya, chifukwa zimatha kuyambitsa kudzimbidwa.

Zidzatengera mavutozomwe zidzakhudze moyo wanu.

Pa chithandizo, ndikofunika kuzindikira kusinthasintha kwa shuga ndi shuga m'magazi ndi mkodzo. Ndi kuwonjezeka kwa kuchuluka kwa magalamu oposa 0.3 patsiku, kuchepa kwakukulu kwa hyperglycemia komanso kuwonjezeka kwa chiwopsezo cha hyperfermentemia ya michere yamatumbo kumachitika.

Miyezi 6 mpaka 6 yoyambirira ya mankhwalawa, ndikofunikira kuwongolera zochitika za michere m'chiwindi. Kumbukirani: shuga amasungunuka pang'onopang'ono, samachotsa hypoglycemia (shuga wotsika) panthawi.

Kuti muchite mwachangu, muyenera kutenga chachikulu Mlingo wa glucose (osati sucrose), ngati nkotheka kudzera m'mitsempha.

Kuyanjana kwa mankhwala

Sulfonylurea, metmorphine, insulin - zinthu zonsezi zimapangitsa mphamvu ya Hypoglycemic. Colestyramine, ma antacid ndi adsorbents omwe amagwira ntchito m'matumbo, m'malo mwake, amachepetsa mphamvu ya mankhwalawa. Chepetsani kuchepa kwa mankhwala:

glucocorticosteroids,
estrogens
mahomoni a chithokomiro,
thiazide okodzeya,
phenothiazines, phenytoin,
kulera kwamlomo
nicotinic acid
isoniazid
adrenostimulator yomwe imayambitsa hypoglycemia.

Zotsatira zoyipa ndi bongo

Pankhani ya bongo, ntchito yapadera ya alpha-glucosidase michere ndi zotsatirapo zoyipa zomwe zalembedwa zimadziwika:

chisangalalo
kutsegula m'mimba
kusanza ndi kusanza
jaundice, chiwindi,
kutupa
zotupa pakhungu,
thrombocytopenia
erythema.

Analogs a Acarbose

Analogue yokhayo ndi mankhwala Glucobayzomwe zimapangidwa ku Germany. Amapezeka m'mapiritsi okhala ndi zinthu 50 mpaka 100 mg, voliyumu ya mapiritsi 30 mpaka 100 phukusi limodzi.

Itha kugulidwa kokha ndi mankhwala ogulitsa mankhwala.

Osagula mankhwala pa intaneti, m'manja mwanu, kapena m'misika yosagulitsa mankhwala, chifukwa mutha kugula zabodza zomwe sizikutulutsa mphamvu ya Acarbose.