Amoxicillin 875 125 malangizo kuti agwiritse ntchito

Amoxiclav ndi mankhwala obwera kumene omwe amagwira ntchito motsutsana ndi tizilombo toyambitsa matenda osiyanasiyana. Dongosolo lake la amoxicillin ndi clavulanic acid pamwambalo limalimbana bwino ndi zovuta zomwe zimayang'anira onse awiri. Ili ndi mitundu ingapo yotulutsidwa mosiyanasiyana, komwe kumakupatsani mwayi woyenera.

Malangizo ogwiritsira ntchito

Piritsi limodzi lachifundo 1

• Zinthu zogwira ntchito
  • Amoxicillin (mu mawonekedwe a trihydrate) 875 mg.
  • Clavulanic acid (munthawi ya potaziyamu clavulanate) 125 mg.

• Othandizira

  Colloidal silicon dioxide, crospovidone, croscarmellose sodium, magnesium stearate, talc, microcrystalline cellulose.

  Mapangidwe a chipolopolo

  Hypromellose, ethyl cellulose, diethyl phthalate, macrogol 6000, titanium dioxide.

  Pali mapiritsi 7 pachimake. Mu phukusi 2 matuza.

  Zizindikiro zogwiritsidwa ntchito

  • Chithandizo cha matenda opatsirana komanso otupa omwe amayambitsidwa ndi tizilombo tating'onoting'ono ta mankhwala:
    • Zofooka zam'mimba zopumira komanso ziwalo za ENT, kuphatikiza:
      • Pachimake ndi matenda a sinusitis.
      • Pachimake komanso otitis otaya media.
      • Pharyngeal abscess.
      • Tonsillitis.
      • Pharyngitis.
    • Matenda a m'munsi kupuma thirakiti, kuphatikizapo:
      • Pachimake bronchitis ndi bakiteriya wamphamvu.
      • Matenda a bronchitis
      • Chibayo
    • Matenda amitsempha.
    • Matenda azamatenda.
    • Matenda a pakhungu ndi minofu yofewa, kuphatikiza kulumidwa kwa anthu ndi nyama.
    • Mafupa ndi mafupa ofunikira matenda.
    • Matenda amtundu wa Biliary:
      • Cholecystitis.
      • Cholangitis.
    • Matenda a Odontogenic.

  Pharmacokinetics

  Magawo akuluakulu a pharmacokinetic a amoxicillin ndi clavulanic acid ndi ofanana. Amoxicillin ndi clavulanic acid osakanikirana sakukhudzana.

  Zogulitsa

  Mutatha kumwa mankhwalawo mkati, zonse ziwirizi zimapangidwa bwino m'mimba, kudya zakudya sizikhudzana ndi mayamwa. The bioavailability wa amoxicillin ndi clavulanic acid ndi 90% ndi 70%, motero. C _max mu madzi am'magazi amafikira ola limodzi atatha kumwa mankhwalawo ndipo (kutengera mlingo) wa amoxicillin 3-12 μg / ml, wa clavulanic acid - pafupifupi 2 μg / ml.

  Kugawa

  Zonsezi zimadziwika ndi gawo logawika bwino m'madzimadzi ndi minyewa (katulutsidwe ka mphuno, tinthu tating'onoting'ono, tinthu tating'onoting'ono, khutu lamkati, zotuluka zam'mimba, malovu, kutulutsa kwa bronchial, mapapu, chiberekero, mazira, chiwindi, gland ya prostate, minofu ya ndulu, madzimadzi a peritoneal). Mu mkodzo, mankhwalawa amapezeka mozama kwambiri.

  Amoxicillin ndi clavulanic acid simalowa magazi chotchinga magazi (Kuchokera ku chi Greek. Αἷμα - magazi ndi εγκεφcyλος - ubongo) ndi njira yotengera ndi kupangira thupi kwa minofu yaubongo yomwe imayendetsa kagayidwe pakati pa magazi ndi minyewa ya muubongo. Imaletsa kulowa kwa mitundu ingapo ya mankhwala m'magazi amanjenje kuchokera m'magazi, kuphatikiza zinthu zomwe zimalepheretsa kagayidwe kazakudya, poizoni, mankhwala osokoneza bongo, komanso ma tizilombo (ma bacteria, ma virus). G. yokhala ndi magetsi opanda mafuta.

  Zinthu zodutsa zimadutsa chotchinga ndipo poyang'ana mozama zimafukusidwa mkaka wa m'mawere. Mlingo womangidwa kumapuloteni a plasma ndi wotsika.

  Kupenda

  Amoxicillin amaphatikizidwa pang'ono, acid yaclavulanic imachitika kagayidwe kakang'ono.

  Kuswana

  Amoxicillin amachotseredwa ndi impso pafupifupi osasinthika ndi kubisalira kwa tubular ndi kusefera kwa glomerular. Clavulanic acid imapukusidwa ndi kusefera kwa glomerular, mwanjira ina ya metabolites. Zing'onozing'ono zimatha kupukusidwa kudzera m'matumbo ndi m'mapapu. T _1/2 amoxicillin ndi 78 min. T _1/2 clavulanic acid ndi mphindi 60-70.

  Pharmacokinetics mu milandu yapadera yamankhwala

  Mumada nkhawa ndi prostatitis? Sungani ulalo

  A kwambiri aimpso kulephera T _1/2 ukuwonjezeka mpaka maola 7.5 a amoxicillin ndi maola 4.5 a clavulanic acid.

  Zonsezi zimachotsedwa ndi hemodialysis ndi zochepa pang'onopang'ono ndi peritoneal dialysis.

  Clinical Pharmacology

  Anti-wodziwika wa antiotic, ili ndi semisynthetic penicillin amooticillin ndi β-lactamase inhibitor clavulanic acid. Clavulanic acid imapereka zovuta zolembedwa zomwe zimakhala ndi ma enzymes awa ndikuwonetsetsa kukana kwa amoxicillin pazotsatira za β-lactamases zopangidwa ndi tizilombo.

  Clavulanic acid, yofanana ndi mankhwala a β-lactam, ali ndi mphamvu yofooka ya antibacterial.

  Amoxiclav ikugwira ntchito yolimbana ndi tizilombo tating'onoting'ono ta amoxicillin, kuphatikiza mitundu yopangira β-lactamases, kuphatikizapo:

  • Mabakiteriya olimbitsa thupi aerobic:
    • Streptococcus pneumoniae.
    • Streptococcus pyogene.
    • Streptococcus viridans.
    • Streptococcus bovis.
    • Enterococcus spp.
    • Staphylococcus aureus (kupatula michere yolimbana ndi methicillin).
    • Staphylococcus epidermidis (kupatula michere yolimbana ndi methicillin).
    • Staphylococcus saprophyticus.
    • Listeria spp.
  • Mabakiteriya olakwika a aerobic:
    • Bordetella pertussis.
    • Brucella spp.
    • Campylobacter jejuni
    • Escherichia coli
    • Gardnerella vaginalis
    • Haemophilus ducreyi
    • Haemophilus influenzae
    • Helicobacter pylori
    • Klebsiella spp.
    • Moraxella catarrhalis
    • Neisseria gonorrhoeae
    • Nisseria meningitidis
    • Pasteurella multocida
    • Proteus spp.
    • Salmonella spp.
    • Shigella spp.
    • Vibrio cholerae
    • Yersinia enterocolitica
    • Eikenella corrodens.
  • Zoyipa zaramram:
    • Peptococcus spp.
    • Peptostreptococcus spp.
    • Clostridium spp.
    • Madalin
    • Fusobacterium spp.
    • Prevotella spp.
  • Ma gram alibe ana
    • Bacteroides spp.

  Mapiritsi oyera kapena pafupifupi oyera, ozungulira, a biconvex okhala ndi mbali zokutidwa, zokutira ndi ulusi wa kanema, mbali ina ya notch ndipo extrated "875/125", mbali inayo "AMC" idachotsedwa.

  Zotsatira za pharmacological

  Amoxiclav® 2X ndi kuphatikiza kwa amoxicillin, mankhwala othana ndi penicillin omwe ali ndi zochitika zambiri za bactericidal, ndi clavulanic acid, choletsa chosasinthika cha b-lactamase chomwe chimapanga zovuta chokhazikika ndi enzyme iyi ndipo motero chimateteza amoxicillin kuvunda.

  Monga penicillin ena olembetsedwa, amoxicillin amalepheretsa kapangidwe ka khungu. Mtundu wa chochitachi ndi bactericidal.

  Amoxiclav® 2X ili ndi zochitika zosiyanasiyana. Imagwira ntchito yolimbana ndi tizilombo tating'onoting'ono ta amoxicillin, komanso zotsatirazi zosagwira, ndikupanga mabakiteriya a b-lactamase:

  Ma gror-positive aerobes: Streptococcus pneumoniae, S. pyogenes, S. viridans, S. bovis, Staphylococcus aureus (cromemeticillin zosagwira zovuta), S. epidermidis (kupatula methicillin zosagwira zovuta), Listeria spp. Enteroccocus spp.

  Ma gror-negative aerobes: Bordetellapertussis, Brucella spp., Campylobacter jejuni, E. coli, Gardnerella vaginalis, H. fuluwenza, H. ducreyi, Klebsiella spp., Moraxella catarrhalis, N..gonorrhoeae, N. meningitidis, Pasteurelamultocida, Proteus spp., Salmonella spp., Shigella spp., Vibrio cholerae, Yersenia enterocolitica.

  Anaerobes: Peptococcus spp., Peptostreptococcus spp., Clostridium spp., Bacteroides spp., Actinimycesisraelli.

  Contraindication

  - hypersensitivity kuti amoxicillin, clavulanic acid kapena chilichonse cha mankhwala

  - matupi awo sagwirizana ndi mankhwala aliwonse a beta-lactam (monga penicillin ndi cephalosporins) m'mbiri

  - kukanika kwambiri kwa chiwindi, komanso odwala omwe ali ndi mbiri ya cholestatic jaundice kapena kukanika kwina kwa chiwindi komwe kumachitika ndi penicillin kapena amoxicillin / clavulanic acid.

  Mimba komanso kuyamwa

  Zomwe zikuwonetsedwazo zikuwonetsa kusakhalapo kwa zotsatira zosasangalatsa za amoxicillin / clavulanic acid pa nthawi yomwe ali ndi pakati, komanso pa mwana wosabadwa komanso wakhanda. Komabe, kafukufuku wapakati pa amayi apakati omwe ali ndi vuto lodzala zam'mimbamo yamadzi anati

  Kugwiritsa ntchito prophylactic wa amoxicillin / clavulanic acid kumatha kuphatikizidwa ndi chiopsezo chowonjezeka cha necrotizing enterocolitis kwa akhanda. Ngati chisamaliro, Amoxiclav® 2X pa nthawi yoyembekezera iyenera kugwiritsidwa ntchito pokhapokha ngati dokotala akuwona kuti phindu la mankhwala limaposa ngozi zomwe zingatheke.

  Panthawi yoyamwitsa, kuphatikiza kwa amoxicillin / clavulanic acid titha kugwiritsidwa ntchito.Kupatula kupezeka kwa chiwopsezo cha chidwi chokhudzana ndi kumasulidwa kwa kuchuluka kwa mankhwalawa mu mkaka wa m'mawere, palibe zotsatira zoyipa zilizonse pa ana oyamwitsa.

  Zambiri za momwe mankhwalawa amatha kuyendetsa magalimoto ndi machitidwe ake owopsa

  Amoxicillin / clavulanic acid ali ndi mphamvu yofooka kwambiri pakutha kuyendetsa galimoto komanso njira zovuta.

  Nthawi zina, amoxicillin / clavulanic acid imatha kuyambitsa zosafunikira monga chisokonezo, chizungulire komanso kukokana, zomwe zimatha kufooketsa kuyendetsa galimoto ndi njira zovuta komanso / kapena kugwira ntchito mosatekeseka.

  Mlingo ndi makonzedwe

  Akuluakulu ndi ana opitirira zaka 12 zakubadwa (kapena zoposa 40 makilogalamu a kulemera kwa thupi): Mulingo wamba wamatenda opatsirana komanso ocheperapo ndi piritsi limodzi la 625 mg maola 12 aliwonse, ngati muli ndi matenda oopsa, piritsi limodzi la 1000 mg maola 12 aliwonse.

  Ana: Mapiritsi a Amoxiclav® 2X samapangidwira ana osakwana zaka 12 (kapena ochepera 40 makilogalamu a thupi).

  Mlingo wapamwamba wa tsiku lililonse wa Amoxiclav® 2X ndi mapiritsi 4 a akulu.

  Kutalika kwa nthawi ya mankhwala kutsimikiza ndi zovuta matenda ndi ntchito ya tizilomboti.

  Nthawi yayitali ya chithandizo ndi masiku 5-10.

  Mlingo wa matenda odontogenic: piritsi limodzi la 625 mg maola 12 aliwonse kwa masiku 5.

  Mlingo wa kulephera kwa aimpso: Kwa odwala omwe amalephera kupezeka aimpso (creatinine chilolezo 10-30 ml / min), mlingo ndi piritsi 1 625 mg maola 12 aliwonse,

  Kwa odwala omwe ali ndi vuto la aimpso kulephera (kuvomerezedwa kwa creatinine osakwana 10 ml / min), mlingo ndi piritsi limodzi la 625 mg maola 24 aliwonse.

  Mu anuria, gawo pakati pa dosing liyenera kuchuluka mpaka maola 48 kapena kupitirira.

  Zotsatira zoyipa

  - maliseche candidiasis, mucocutaneous candidiasis

  - nseru, kusanza, kutsegula m'mimba, kuyabwa m'dera la anal

  - zotupa pakhungu, kuyabwa, urticaria

  - thrombocytosis, kuchepa kwa magazi m'thupi

  - chizungulire, kupweteka mutu komanso kukokana

  - kupweteka kwam'mimba, stomatitis, colitis, colitis yokhudzana ndi kugwiritsa ntchito maantibayotiki (kuphatikizapo pseudomembranous colitis ndi hemorrhagic colitis)

  - zina kuwonjezeka kwa ASAT ndi / kapena AlAT

  - leukopenia, granulocytopenia, neutropenia, eosinophilia, thrombocytopenia, pancytopenia, kuchepa magazi, agranulocytosis, myelosuppression, kuchuluka nthawi ya magazi ndi nthawi ya prothrombin

  - lilime lakuda ("lofiirira")

  - interstitial nephritis, hematuria, crystalluria

  - Stevens-Johnson syndrome, poermal necrolysis yoopsa, dermatitis yowopsa, pachimake kwambiri pantulosis (AGEP), matenda a Lyell

  - angioedema, anaphylaxis, serum matenda syndrome, ziwengo vasculitis, mankhwala kutentha

  - hepatitis cholestatic jaundice

  -kukhala mwamantha, nkhawa, kugona, kusokonezeka, kukwiya

  Bongo

  Zizindikiro: Odwala ambiri osokoneza bongo sanawonetse zizindikiro. Komabe, kupweteka kwam'mimba, kupweteka kwam'mimba, kusanza, kutsegula m'mimba, kusokonezeka m'magazi a electrolyte, zotupa pakhungu, Hypersensitivity, kugona, kukokana, kuchepa kwa minyewa, kuchepa kwa chikumbumtima, chikomokere, kutuluka kwa hemolytic, kulephera kwa impso, acidosis ndi crystalluria. Nthawi zina, mantha amatha kuyamba mkati mwa mphindi 20 mpaka 40.

  Chithandizo: wodwalayo ayenera kuyang'aniridwa, ndipo chithandizo choyenera chazamankhwala chiyenera kuperekedwa ngati kuli kofunikira. Ngati mankhwalawa atengedwa posachedwa (maola 4 kapena kuchepera), pakalibe kuphwanya, m'mimba mwa wodwalayo muyenera kutsanulidwa chifukwa chotsuka kapena kuchapa, ndipo wodwalayo apatsidwe makala okuthandizani kuti achepetse kuyamwa. Amoxicillin / potaziyamu clavulan akhoza kuphatikizidwa ndi hemodialysis.

  Kuchita ndi mankhwala ena

  Amoxiclav® 2X silingaphatikizidwe ndi mankhwala ena a bacteriostatic chemotherapeutic / antibacterial (monga chloramphenicol, macrolides, tetracyclines kapena sulfonamides), chifukwa zotsatira zoyipa zimawonedwa.

  Kugwiritsa ntchito nthawi yomweyo mankhwala ndi allopurinol kungakulitse chiopsezo cha zotupa pakhungu.

  Kugwiritsidwa ntchito kophatikizidwa kwa Amoxiclav® 2X ndi methotrexate kungakulitse kuchuluka kwa methotrexate (leukopenia, thrombocytopenia, zilonda zamkhungu).

  Probenecid amachepetsa impso ya katulutsidwe wa amoxicillin. Kugwiritsa ntchito nthawi yomweyo ndi Amoxiclav kungayambitse kuchuluka kwa amoxicillin m'magazi, komabe, izi sizimawonedwa ndi clavulanic acid. Monga maantibayotiki ena opitilira muyeso, Amoxiclav® 2X ikhoza kuchepa mphamvu ya njira yolerera pakamwa. Nthawi zina, mankhwalawa amatha kukulitsa nthawi ya prothrombin, pachifukwa ichi kusamala kuyenera kugwiritsidwa ntchito mukamagwiritsa ntchito anticoagulants ndi Amoxiclav® 2X.

  Aminopenicillin angachepetse plasma sulfasalazin ndende. Mwinanso imawonjezera kuchuluka kwa mayamwidwe a digoxin pomwe imagwiritsidwa ntchito ndi amoxicillin / clavulanic acid.

  Amoxiclav® 2X sayenera kugwiritsidwa ntchito nthawi imodzi ndi disulfiram.

  Zolemba zogwiritsira ntchito

  Pofuna kuchepetsa chiwopsezo cha mavuto obwera kuchokera m'matumbo am'mimba, mankhwalawa amayenera kumwa ndi zakudya.

  Ndi njira ya chithandizo, ndikofunikira kuwunika momwe ntchito ya magazi, chiwindi ndi impso.

  Odwala omwe ali ndi vuto lalikulu kwambiri kapena chifuwa cha mphumu, Amoxiclav® 2X iyenera kugwiritsidwa ntchito mosamala, chifukwa amatha kusokonezeka ndi mankhwala. Odwala omwe ali ndi hypersensitivity ku penicillin, zovuta zomwe zimachitika ndi mankhwala a cephalosporin zimatheka.

  Odwala omwe ali ndi vuto laimpso, Amoxiclav® 2X iyenera kugwiritsidwa ntchito mosamala. Mlingo wake uyenera kuchepetsedwa kapena kulowererapo pakati Mlingo uyenera kukulitsidwa kutengera kuzunza kwa wodwala. Odwala ndi creatinine chilolezo 0

  Kutulutsa Fomu

  Ipezeka mu:

  • mapiritsi okutira
  • ufa wa kuyimitsidwa,
  • lyophilized ufa wa jakisoni.

  Piritsi limodzi 375 mg limakhala ndi 250 mg ya amoxicillin ndi 125 mg ya clavulanic acid.

  Piritsi ya 625 mg imakhala ndi 500 mg ya amoxicillin, 125 mg ya clavulonic acid.

  Othandizira ndi:

  • silicon dioxide (colloid),
  • croscarmellose (mchere wa sodium),
  • magnesium wakuba,
  • talcum ufa
  • hypopellose,
  • cellulose ethyl,
  • polysorbate,
  • titanium dioxide
  • triethyl citrate.

  Mapiritsi amatayikidwa mumbale, 15 zidutswa chilichonse. Bokosi limodzi lili ndi botolo limodzi la mankhwala.

  Poda yoyimitsidwa imapezeka m'mbale zamagalasi zakuda, imodzi pa bokosi. Pali supuni yoyezera. Zomwe zimaphatikizidwa kuyimitsidwa kumaphatikizapo 125 ndi 31.25 mg yogwira zinthu, motero. Pokonzekera kuyimitsidwa "Amoxiclav Forte", 5 ml yake imakhala ndi zinthu zowirikiza kawiri - 250 ndi 62,5 mg, motero. Othandizira ndi:

  • citric acid
  • sodium citrate
  • sodium benzoate
  • carmellose sodium
  • silika colloid,
  • sodium saccharin
  • mannitol
  • sitiroberi ndi zonunkhira zamtchire.

  Mapiritsi a Amoxiclav ndi ufa - malangizo ogwiritsira ntchito

  Kwa ana ochepera zaka 12 - 40 mg pa kilogalamu ya kulemera kwa tsiku.
  Kwa ana omwe kulemera kwawo kupitilira 40 makilogalamu, mankhwalawa amamulembera ngati munthu wamkulu.

  Akuluakulu amalembedwa: Mapiritsi a 375 mg amatengedwa tsiku lililonse la 8 tsiku lililonse, mapiritsi a 625 mg maola 12 aliwonse. Popereka mankhwala othandizira odwala kwambiri, Mlingo wa 625 mg maola 8 aliwonse, kapena 1000 mg maola 12 aliwonse, amagwiritsidwa ntchito.

  Tiyenera kudziwa kuti mapiritsi amatha kusiyanasiyana malinga ndi zomwe zimagwira.Chifukwa chake, simungathe kusintha piritsi la 625 mg (500 g ya amoxicillin ndi 125 g ya clavulanic acid) ndi mapiritsi awiri 375 mg (250 g of amoxicillin ndi 125 g ya clavulanic acid).

  Dongosolo lotsatirali limagwiritsidwa ntchito pochiza matenda a odontogenic. Mapiritsi 375 mg amatengedwa maola 8 aliwonse, pozungulira wotchi. Mapiritsi a 625 mg pambuyo pa maola 12.

  Ngati kuli kofunikira kugwiritsa ntchito mankhwalawa kuchiza odwala omwe ali ndi matenda a impso, mkodzo wa creatinine uyenera kukumbukiridwa. Odwala omwe ali ndi matenda a chiwindi amafunikira kuwunika ntchito yawo nthawi zonse.

  Mphamvu yakuyimitsidwa kwa makanda ndi ana mpaka miyezi itatu. Dosing imachitika pogwiritsa ntchito kapeniki woyezera wapadera kapena supuni. Mlingo - 30 mg ya amoxicillin pa kilogalamu ya kulemera, kawiri pa tsiku.

  Kwa ana okulirapo kuposa miyezi itatu kwa matenda ofatsa komanso odziletsa - 20 mg / kg yolemetsa thupi, komanso matenda oopsa - 40 mg / kg. Mlingo wachiwiri umagwiritsidwanso ntchito pochiza matenda oopsa - kutupa kwa khutu lapakati, sinusitis, bronchitis, chibayo. Malangizo amaphatikizidwa ndi mankhwalawa, momwe mumakhala matebulo apadera omwe amakupatsirani kuti muwerenge molondola kuchuluka kwa mankhwalawa kwa ana.

  Mlingo wovomerezeka wa ana tsiku lililonse ndi ana ndi 45 mg / kg, kwa akulu - 6 magalamu. Clavulanic acid imatha kutengedwa patsiku osaposa 600 mg kwa akulu ndi 10 mg / kg kwa ana.

  Kufotokozera kwa mafomu omasulira

  Mankhwalawa amapezeka mu mawonekedwe a mapiritsi okhala ndi zoyera kapena zoyera. Mapiritsiwo ali ndi mawonekedwe owundana a biconvex.

  Piritsi limodzi la 625 mg limakhala ndi 500 mg ya amoxicillin trihydrate ndi 125 mg ya clavulanic acid (mchere wa potaziyamu).

  Mapiritsi amatha kupanga zitini zamapulasitiki (mapiritsi 15 aliyense) kapena matuza a aluminium a 5 kapena 7.

  Mapiritsi a 1000 mg amaphatikizanso, amakhala ndi mawonekedwe osungika okhala ndi mbali zopindika. Kumbali ina mwa iwo pali zolemba za "AMS", mbali inayo - "875/125". Amaphatikizapo 875 mg ya antiotic ndi 125 mg ya clavulanic acid.

  Chithandizo cha cystitis ndi Amoxicillin: malangizo, ntchito, ndemanga

  

  Kwa zaka zambiri osavutika ndi PROSTATE ndi POTENTIAL?

  Mkulu wa Sukulu: “Mudzadabwitsidwa kuti ndi kosavuta motani kuchiritsa matenda a prostatitis mwa kumwa tsiku lililonse.

  Cystitis ndizofala kwambiri mwa azimayi amisinkhu yosiyanasiyana. Matendawa amathandizidwa makamaka ndi antibacterial mankhwala. Amoxicillin amadziwika kuti ndiothandiza kwambiri.

  Zokhudza thupi

  

  Amoxicillin imathandiza kwambiri cystitis chifukwa imatengedwa mwachangu ndi thupi. Sichiwonongeka mchikakamizo cha madzi am'mimba. Chifukwa chake, mankhwalawa amayenera kuwerengedwa molondola komanso mosamalitsa.

  Kamodzi m'thupi, Amoxicillin amayamba kupanga chinthu chotchedwa transpeptidase. Imalimbana ndi microflora ya pathogenic, ndikuwawononga pamlingo wa ma cell. Izi zimalepheretsa kukula ndi kubereka kwa tizilombo tating'onoting'ono, ndipo timatulutsa m'thupi.

  Choipa cha mankhwalawa ndikuti pakuwonongeka kwa ma virus maiyo amapanga poizoni wambiri. Izi zitha kusokoneza wodwalayo. Kumva kusasangalala kumatha kupitilira tsiku lonse.

  Kafukufuku wambiri akuwonetsa kuti mankhwalawa amagwira paziphuphu monga:

  1. Staphylococci,
  2. Streptococcus
  3. Salmonella
  4. Shigella
  5. Klebsiella,
  6. E. coli.

  Magawo a mankhwalawa amalowa m'magazi ndikufalikira thupi lonse. Kusintha kumatha kuonedwa patatha maola ochepa mutatha kumwa mankhwalawo.

  Pali mitundu itatu ya mankhwala:

  1. Mapiritsi Wofatsa poyerekeza ndi mitundu ina ya mankhwalawa. Amagwiritsidwa ntchito ngati cystitis yayikulu kapena yoyambira,
  2. Makapisozi Mofikira kwambiri tsamba la kutupa ndikuchitapo kanthu. Itha kugwiritsidwa ntchito ngati thandizo loyamba la cystitis, komanso cystitis yokhala ndi tizilombo toyambitsa matenda osadziwika,
  3. Kuyimitsidwa Njira yosavuta komanso yofatsa kwambiri. Nthawi zambiri amapangidwa ndi kukoma kosangalatsa.Amagwiritsidwa ntchito pofuna kuchiza cystitis mwa ana azaka zitatu, komanso ngati ali ndi pakati.

  Pambuyo maola ochepa, mankhwalawo amafikira chikhodzodzo. Mmenemo amapeza cholinga chotupa ndikuyamba ntchito yake. Kutulutsa kwake mu mkodzo ndikokwera kwambiri, izi zimakupatsani mwayi wothana ndi tizilombo toyambitsa matenda a cystitis. Amoxicillin amachotsedwa kwathunthu mthupi ndi impso ndi chiwindi.

  Njira ya mankhwala ndi kumwa

  

  Kuti mupewe mavuto, ndikofunikira kumwa Amoxicillin osapitilira muyeso. Zochizira pachimake cystitis, achikulire mankhwala zotchulidwa 500 g. Ndalamazi ziyenera kumwedwa katatu patsiku. Ndikofunika kuti kuchuluka komwe kumadutsa nthawi yolandirana. Chifukwa chake muyenera kulandira chithandizo masiku pafupifupi asanu ndi awiri. Nthawi zina, adotolo amawonjezera maphunzirowa mpaka masiku 10.

  Cystitis mwa ana

  

  Mankhwalawa cystitis ya ana, Mlingo umasiyana ndi chithandizo cha akuluakulu. Makolo ayenera kukumbukira kuti Amoxicillin ndi mankhwala osokoneza bongo omwe amatha kukhudza thupi la ana, chifukwa chake muyenera kufunsa dokotala wa ana musanagwiritse ntchito.

  Kuyimitsidwa kuli koyenera kwa ana. Amapangidwa mwanjira yoti chamoyo chochepa chomwe chimapanga msanga chofunikira. Mankhwalawa amakonzedwa mwa njira yothetsera. Agamu a Amoxillicin amathiridwa ndimadzi ndikugwedezeka, mankhwalawa amakonzedwa kamodzi munthawi yonse ya mankhwalawa. Mutha kusunga zomwe zakonzedwa kwa masiku osapitilira 12. Wopereka mankhwala amabwera ndi botolo, izi zimapangitsa kuti mankhwalawa akhale osavuta.

  Ndikwabwino kusiya mankhwalawo m'chipinda chamdima komanso chodetsa, ndikugwedezeka bwino musanagwiritse ntchito.

  Ndani sayenera kumwedwa

  

  Amoxicillin ndi wa ma penicillin. Imagwira bwino kwambiri motsutsana ndi E. coli, yomwe imayambitsa kwambiri cystitis. Koma mankhwalawa sioyenera kwa iwo omwe ali ndi vuto la penicillin, apo ayi zotupa ndi zovuta zina zimatha kuonekera.

  Mankhwalawa amaletsedwa kuyamwitsa amayi, chifukwa amatha kudutsa mkaka wa m'mawere ndikuwononga thanzi la mwana. Mwanayo akhoza kuyamba kusokonezeka kapena matumbo am'mimba osokonezeka. Ngati cystitis ilipo nthawi yotsitsa, ndikofunikira kufunafuna thandizo kuchokera ku njira zotetezeka, monga Flemoxin ndi Ampicillin.

  Kuphatikizidwa kwa mankhwalawa ndi mowa kumatha kuyambitsa ziwopsezo zazikulu, ngakhale kufa. Mowa wophatikizidwa ndi antibayotiki umakhala ndi mphamvu poizoni. Chiwalochi chitha kupuwala. Mukhoza kumwa mowa pokhapokha sabata, ndipo makamaka awiri atatha maphunzirowo, mankhwalawo atachokanso m'thupi.

  Anthu omwe ali ndi hypersensitivity cephalosporins, carbapenems, pofuna kupewa mavuto azaumoyo, ndibwino kusiya mankhwalawa ndikusankha njira yoyenera kwambiri. Matenda a mphumu sayeneranso kuyesa Amoxicillin. Zimaphatikizapo kuthekera kotenga mankhwalawa komanso kukhalanso kwa matenda a mononucleosis.

  Amoxicillin wa amayi oyembekezera

  Mphamvu ya maantibayotiki thupi la mayi wapakati ndi mwana wosabadwa sichinaphunzire. Panalibe milandu yovulaza, koma nthawi zambiri cystitis mwa amayi oyembekezera amakonda kuthandizidwa m'njira zina.

  Amoxicillin amalembedwa pokhapokha ngati phindu kwa mayi limaposa chiwopsezo kwa mwana.

  Zotsatira za kugwiritsidwa ntchito molakwika

  

  Amoxicillin amalimbana ndi tizilombo toyambitsa matenda ambiri, koma ngakhale zili choncho, zimatha kuvulaza thupi. Nthawi zambiri, pamakhala kuwunika kwa odwala komwe kumachitika chiphuphu pakumwa mankhwala. Kuchita koteroko ku Amoxicillin kuwonekera, dokotala ayenera kusankha mankhwala ena ochizira cystitis.

  Makolo ambiri amasiya ndemanga zabwino za mankhwalawa ndipo amangokonda mankhwalawa cystitis ya ana. Amakondwera ndi kusapezeka kwa matenda otsegula m'mimba ngati mbali yothandizira komanso kuchira msanga. Koma ngati matenda am'mimba adayamba, mutha kumwa mankhwala otsutsana ndi izi.Kukonzekera kotsutsana komwe kuli ndi attapulgite ndi komwe kumaloledwa. Mankhwala ena aliwonse amatha kutsitsa matumbo.

  Zomwe chamoyo chilichonse chimapanga Amoxicillin zimangokhala zokha. Mankhwala amodzi atha, pomwe ena amafunika kupeza njira ina.

  Pakhoza kukhala kuphwanya ntchito za zida zapamwamba, chilimbikitso cha kusanza, chizungu. Chisokonezo ndi nkhawa zimawonetsedwanso nthawi yamankhwala.

  

  Ndemanga za Amoxicillin zomwe zimapezeka pa intaneti ndizotheka. Ambiri amazindikira kuti mankhwalawa amathandizira kwambiri kuchira ndikukulolani kuti muchotse matendawa. Kuphatikiza apo, ndikofunikira kwambiri kutenga (machitachita ngakhale musanadye kapena musanadye).

  Pali zowunikira zochepa. Nthawi zambiri amadandaula kuti mankhwalawo sanathandize. Komabe ndikofunikira kukumbukira kuti ngakhale mankhwalawa ndi othandiza kwambiri, samathandiza polimbana ndi tizilombo tating'onoting'ono tonse tomwe tingathere. Chifukwa chake, musanagwiritse ntchito, ndikofunikira kuyesedwa kuti mupeze tizilomboti. Kuwerenga koteroko kumafunikira nthawi yowonjezera, chifukwa madokotala ambiri amangoilambalala, ndikumapereka mankhwala mwachisawawa.

  Zotsatira zoyipa

  Nthawi zambiri zimakhala zosavuta kudutsa komanso kulekerera mosavuta ndi odwala. Zotsatira zoyipa zimatha kuchitika mwa odwala okalamba, komanso mwa odwala omwe amagwiritsa ntchito Amoxiclav nthawi yayitali. Nthawi zambiri, zotsatira zoyipa zimachitika pakumala kapena kumaliza chithandizo, koma nthawi zina chitukuko chake chimachitika patatha milungu ingapo mutamaliza mankhwalawa.

  Matumbo oyenda. Monga lamulo, uku ndi kutsekula m'mimba, mseru, kusanza, komanso dyspepsia. Flatulence, stomatitis kapena gastritis, kusinthika kwa lilime kapena glossitis, enterocolitis ndiyofala. Nthawi ya mankhwala atamaliza kapena itatha, pseudomembranous colitis imatha - matenda omwe amayamba chifukwa cha mabakiteriya amtundu wa clostridium.

  Magazi. Matendawa (kuphatikiza hemolytic), eosinophilia, kuchepa kwa maselo ambiri komanso / kapena leukocytes, agranulocytosis amathanso kuchitika.

  Machitidwe amanjenje atha kumwa mankhwalawa ndi mutu, chizungulire, kukwiya, kusowa tulo, kukomoka, kusachita bwino kapena kufooka.

  Chiwindi. Zizindikiro za mayeso a hepatic zimawonjezeka, kuphatikiza ntchito ya AsAT ndi / kapena AlAT, phosphatase ya alkaline ndi serum bilirubin asymptomatic kuchuluka.

  Khungu. Khungu limatha kuyankha pakudya kwa amoxiclav ndi totupa, ming'oma, angioedema, erythema multiforme, poyizoni epermermal necrolysis, exfoliative dermatitis, matenda a Stevens-Johnson.

  Njira yamikodzo - pali mawonekedwe a magazi mumkodzo ndi interstitial nephritis.
  Pogwiritsa ntchito mankhwalawa kwa nthawi yayitali, malungo, milomo yamkamwa, komanso ma feminitis owonekera.

  Kugwirizana kwina ndi mankhwala ena

  • Ndiosafunika kugwiritsa ntchito nthawi yomweyo Amoxiclav ndi kukonzekera kwa anticoagulants. Izi zingayambitse kuchuluka kwa prothrombin nthawi.
  • Kuchita kwa Amoxiclav ndi allopurinol kumayambitsa chiopsezo cha exanthema.
  • Amoxiclav imawonjezera kawopsedwe wa metatrexate.
  • Simungagwiritse ntchito onse amoxicillin ndi rifampicin - awa ndi osokoneza, ophatikizira ntchito amachepetsa mphamvu ya antibacterial onse.
  • Amoxiclav sayenera kulembedwa pamodzi ndi tetracyclines kapena macrolides (awa ndi mankhwala opatsirana a bacteriostatic), komanso sulfonamides chifukwa chakuchepa kwa mphamvu ya mankhwalawa.
  • Kutenga Amoxiclav kumachepetsa mphamvu zakulera m'mapiritsi.

  Kupanga ndi mawonekedwe a kumasulidwa

  Kupanga ndi mawonekedwe a kumasulidwa

  Mankhwalawa akuphatikiza amoxicillin, yomwe ndi semisynthetic penicillin, yofanana ndi katundu wake ku ampicillin, koma akhoza kuyamwa bwino. Amadziwika chifukwa cha antibacterial zochita zake. Chotsatira chotsatira ndi clavulanic acid.Imaphatikizidwa pamndandanda wa zoletsa zosasintha - lactamases. Imalimbikitsa mapangidwe a chitetezo chokwanira cha amoxicillin ku mphamvu ya beta-lactamases yopangidwa ndi tizilombo toyambitsa matenda. Clavulanic acid, monga gawo lina, ilibe kutchulidwa kwa antibacterial.

  Piritsi iliyonse imakhala ndi zosakaniza zonse ziwiri, voliyumu ya clavulanic acid ndi 125 mg, zomwe amoxicillin amapanga mu mawonekedwe a trihydrate ndi 875 mg.

  Zowonjezera zina ndi colloidal silicon dioxide, zomwe zili 5.4, crospovidone mu voliyumu ya 27.4, croscarmellose sodium 27.4 mg, magnesium stearate 12, microcrystalline cellulose mpaka 1435 mg.

  Amoxicillin amatanthauza semisynthetic penicillin, wofanana ndi ampicillin, koma bwino pakamwa bioavailability. Imakhala ndi zochita motsutsana ndi gramu zabwino komanso gramu-hasi. Imawononga biosynthesis wa peptidoglycan, chida chomangira mabakiteriya. Zomwe, zimatsogolera pakuwonongeka kwa tizilombo. Amoxicillin palokha imawonongedwa pakukhudzana ndi beta-lactamases, motero, ilibe mphamvu motsutsana ndi tizilombo tating'onoting'ono timene timayambitsa enzyme iyi.

  Clavulanic acid, ndiyo chopinga chifukwa cha beta-lactamases. M'makhalidwe ake, ndi ofanana ndi penicillin. Koma imatha kulepheretsa mabakiteriya omwe sangadwale ndi penicillin ndi cephalosporin. Acid iyi imathandizira pakuwongolera kwa plasmid beta-lactamases.

  Clavulanic acid imalepheretsa kuwonongeka kwa amoxicillin mothandizidwa ndi beta-lactamases. Katunduyu amakupatsani mwayi wowonjezera antibacterial.

  Mabakiteriya otsatirawa samvera bwino tandem clavulanic acid wokhala ndi amoxicillin:

  1. Mabakiteriya okhala ndi gram: anthrax causative agent, fecal enterococcus, listeriosis causative agent, bacteria wa streptococcus, gulu A beta-hemolytic, staphylococcus saprophytic.
  2. Ma grram-negative aerobes: wambiri chifuwa, haemophilus fuluwenza, helicobacter pylori, moraxella cataralis, gonococcus, pasteurellosis, cholera vibrio.
  3. Tizilombo tina tating'onoting'ono: tizilombo toyambitsa matenda a borreliosis, leptospirosis, paleponema wotumbululuka.
  4. Ma anaerobes abwino a gramu: clostridia, peptococcus, peptostreptococcus.
  5. Mabakiteriya osokoneza bongo a gram: bacteroid fraglis, mitundu ya majini a bacteroid, capnocytophages, bacillus wa Plaut, fusobacteria, mitundu ya porphyromonad, Prevotella. Mabakiteriya ena amatha kuzolowera zochita za Amoxiclav. Mwa ma gram-negative aerobes, iyi ndi Escherichia coli, Klebsiella oxetoca, ndodo ya Friedlander, Klebsiella chibayo, Klebsiella, Proteus mirabilis, Proteus vulgaris ndi Proteus, bacteria wa Salmonella, Shigella.
  6. Ma gror-positive aerobes: mabakiteriya a corynebacterium, enterococcus faecium, pneumococcus, streptococcus gulu la Viridans. Pali tizilombo tating'onoting'ono tambiri timene timakhala ndi mphamvu zotsutsana ndi zachilengedwe za Amoxiclive 875 + 125.
  7. Mitundu ya grram-negative aerobes: mitundu ya mtundu wa acinetobacter, freundi citrobacter, mitundu ya genobus ya enterobacter, hafnium, pneumophilus legionella, Morgana bacterium, mitundu ya proidence, mitundu ya pseudomonas, mitundu ya seration genus, maltophilia stenotrophomonas, yersinia entocolitia.
  8. Mabakiteriya ena: chlamydophil chibayo, chlamydophil psittaci, mabakiteriya amtundu wa chlamydia, causative othandizira a coxiellosis, mitundu ya genus mycoplasma.

  Zochita zawo, zonse zazikulu za Amoxiclav ndizofanana, zimabalalitsa mayankho amadzimadzi ndipo, pambuyo pa njirayi, zimayamba kugwira ntchito, ndikuthiridwa kwathunthu kuchokera m'mimba. Ikakumwa pamimba yopanda kanthu, imakamizidwa bwino. Ngati mutamwa mankhwalawa mukatha kudya, mphamvu yake yogaya chakudya ndi 70% yokha.

  Chigawo chilichonse cha Amoxiclav 875 chimakhala ndi nthawi yake yambiri yamagazi. Momwemo amoxillin amafikira pachimake pafupifupi maola awiri, pomwe mnzake kale, pambuyo pa 1.25. Hafu ya moyo wawo onse ndi pafupifupi ola limodzi.

  Onse amoxicillin ndi clavulanic acid amagawidwa popanda mavuto m'thupi, kulowa mkati ziwalo zonse ndi madzi sing'anga. Popeza mankhwalawa amatupa, samadutsa chotchinga magazi.

  Onse amatha kulowa mkaka wa m'mawere, ndipo popanda mavuto kulowa mkatikati mwa placenta.

  Mpaka kotala la amoxicillin imachoka kudzera mu impso mu mawonekedwe a penicilloic acid. Clavulanic acid imapangidwa mosamala, umapezeka pang'ono ndi mkodzo, pang'ono pang'onopang'ono m'mimba, pang'ono ndi mpweya womwe watha.

  Kukula kwakukulu, mankhwalawa amadutsa impso, koma asidi wa clavulanic nawonso amawonjezeredwa ndi makina owonjezera.

  Ndi kuwonongeka kwa aimpso, kugunda kwa zinthu kumachepa mogwirizana ndi kuchepa kwa impso.

  Ngati chiwindi chayamba kugwira ntchito, muyenera kugwiritsa ntchito mosamala, kwinaku ndikuwunika chiwindi.

  Kusankhidwa

  Matenda opatsirana kwambiri.

  • Matenda a m'mapapo ndi ma pathologies a ziwalo za ENT - zotupa ndi zotupa zoyipa, magawo angapo a kutupa kwa khutu, kutupa kosafunikira m'malo a pharyngeal, kutupa kwamatumbo, pharyngitis, bronchitis, chibayo,
  • Njira zopatsirana pamkodzo
  • Matenda opatsirana m'magulu azachipatala,
  • Zilonda zopatsirana pakhungu ndi minofu yofewa, kuphatikiza kuluma kwa anthu ndi nyama,
  • Matenda osiyanasiyana amtundu ndi mafupa ofala ndimatenda opatsirana,
  • Njira zoyeserera (kutupa kwa ndulu ndi ndulu zake),
  • Matenda a Odontogenic.

  Amoxiclav 875 - malangizo ntchito

  Malangizo a kumwa mankhwala

  Mlingo wa Amoxiclav amasankhidwa payekhapayekha pa vuto lililonse

  kutengera ndi kuopsa kwa matendawa, kulemera kwake, msinkhu wa wodwalayo, momwe zinthu zilili m'thupi mwake.

  Koma Mlingo, monga lamulo, umangoperekedwa kwa mitundu yayikulu yamatendawa.

  Zambiri. Tengani musanadye, izi zidzatsogolera kugawa kwathunthu zinthu zogwira ntchito mthupi, kuchepetsa chiopsezo cha mavuto.

  Nthawi zambiri, njira ya mankhwalawa imatha milungu iwiri. Ngati pambuyo pa nthawi imeneyi palibe kuchira komwe kwachitika, kufunsa kwa dokotala ndikofunikira.

  Matenda omwe amapezeka modekha kwambiri komanso mwamphamvu amathandizidwa motere: 875 mg kawiri patsiku.

  Pankhani ya kuwonongeka kwa impso, kusintha kwa Mlingo umodzi kuyenera kukhala kokha ndi maso kupangira chilolezo. Mlingo waukulu kwambiri wa 875 mg ukhoza kutumikiridwa pokhapokha ndi mtengo wa> 30 ml / min. Nthawi zina, awa ayenera kukhala ochepa mlingo woyambitsidwa ndi mankhwala ena.

  Ndi zovuta za chiwindi zomwe zilipo, Amoxiclav imatengedwa mosamala kwambiri, kuyang'anira chiwindi chonse.

  Madokotala amafufuza

  Anna Leonidovna, wothandizira, Vitebsk. Amoxiclav imakhala yothandiza kwambiri pochiza matenda osiyanasiyana opuma kuposa momwe analogue, amoxicillin. Ndikupereka maphunzirowa masiku 5, kenako ndikofunikira kumwa mankhwala omwe amakonzanso microflora.

  Veronika Pavlovna, dotolo. Mr. Kreshyi Rih. Mankhwalawa ali ndi vuto labwino kwambiri pakulimbana ndi bakiteriya a kumaliseche. Sichimaperekanso zovuta, nthawi yomweyo ndimapereka mankhwala a antifungal, nditatha kumwa ma probiotic kuti ndikonzenso microflora yachilendo.

  Andrei Evgenievich, dotolo wa ENT, Polotsk. Kugwiritsa ntchito mankhwalawa jekeseni kumakuthandizani kuti muchepetse kuwonetsa kwa matenda oopsa komanso olimbitsa a ziwalo za ENT. Mankhwala amathandizira kutukusira khutu lapakati. Kuphatikiza apo, odwala amatenga bwino kuyimitsidwa kwa zipatso.

  Ndemanga za Odwala

  Victoria, Dnipropetrovsk. Kugwiritsidwa ntchito ndi adokotala pochiza matenda a tonsillitis. Anaona masiku 5. Mankhwala olimbana ndi mankhwalawa adayamba patsiku la 3 la matenda. Matendawa adachepetsa ndi wachitatu. Khosi langa linasiya kuwawa. Panali matenda otsegula m'mimba, ndinadutsa patangotha ​​masiku awiri, nditayamba kumwa mankhwala okonzanso kuti ndikonzenso microflora.

  Alexandra, mzinda wa Lugansk. Mankhwalawa adalembedwa ndi dokotala kuti azichiza pyelonephritis. Maphunzirowa anali masiku 7. Jekeseni wa masiku atatu - kenaka mapiritsi.Jakisoni amakhala wowawa. Komabe, kusintha kunayamba mozungulira tsiku lachinayi. Panalibe mavuto. Ndiye kamwa youma ija.

  Tamara, mzinda wa Boyarka. Adandilowetsa mankhwalawa ngati mankhwalawa. Zimakhala zopweteka kwambiri, mikwingwirima idatsalira pamalo a jakisoni. Komabe, patatha sabata limodzi palibe chomwe chatsalira mu smears kuchokera kwa pathogen.

  Zowonjezera

  Ngati mankhwalawa amagwiritsidwa ntchito kwanthawi yayitali, ndikofunikira kuyang'anira ntchito ya chiwindi, ziwalo zopanga magazi ndi impso za wodwalayo. Ngati wodwalayo wasokoneza ntchito yaimpso, ndikofunikira kusintha mlingo kapena kuonjezera pakadali pakati Mlingo wa mankhwala. Ndikwabwino kumwa mankhwala ndi chakudya. Pankhani ya superinfection (mawonekedwe a microflora osazindikira maantibayotiki), ndikofunikira kusintha mankhwalawa. Chifukwa chakuchulukana kwa matupi a cephalosporins mwa odwala omwe ali ndi penicillin, sikofunikira kugwiritsa ntchito maantibayotiki nthawi imodzi.

  Mukamamwa mankhwalawa, muyenera kumwa madzi ambiri kuti mupewe mapangidwe amkodzo wa amoxicillin.

  Mukuyenera kudziwa kuti kupezeka kwa Mlingo wambiri wa maantibayotiki mthupi kumatha kupangitsa kuti shuga azigwirizana ndi mkodzo (ngati malingaliro a Benedict kapena njira ya Fleming agwiritsidwa ntchito kuti adziwe). Zotsatira zodalirika pamenepa zimapereka ntchito ya enzymatic reaction ndi glucosidase.

  Popeza zotsatira zoyipa za m'magazi amanjenje ndizotheka kugwiritsa ntchito mankhwalawa, ndikofunikira kuyendetsa bwino magalimoto (magalimoto) kapena kuchita zinthu zomwe zimafunikira chidwi, kuthamanga ndi chidwi.

  Amoxiclav ndi mankhwala obwera kumene omwe amagwira ntchito motsutsana ndi tizilombo toyambitsa matenda osiyanasiyana. Dongosolo lake la amoxicillin ndi clavulanic acid pamwambalo limalimbana bwino ndi zovuta zomwe zimayang'anira onse awiri. Ili ndi mitundu ingapo yotulutsidwa mosiyanasiyana, komwe kumakupatsani mwayi woyenera.

  Malangizo apadera

  Kuti muchepetse chiwopsezo cha zochitika zosafunikira kuchokera m'matumbo am'mimba, Amoxiclav ayenera kumwedwa kokha ndi chakudya.

  Poyerekeza ndi momwe mankhwalawo amathandizira, pali kuthekera kwa kutchuka kwambiri, koma ngati thupi lili ndi mabakiteriya omwe samva chidwi ndi zinthu izi.

  Ngati mononucleosis ya genesis yopatsirana imatha kuchitika, mankhwala oyenera ayenera kusankhidwa kuchokera ku analogues.

  Pachizindikiro choyamba cha colitis chokhudzana ndi maantibayotiki, chithandizo chiyenera kuyimitsidwa nthawi yomweyo.

  Kuchita mkodzo kumatha kuwonetsa magawo olakwika a kupezeka kwa shuga mu mkodzo.

  Ngati chizungulire, kukhumudwa komanso kupatutsidwa kwapakati mkati wamanjenje poyendetsa, ndibwino kukana.

  Mowa mukamamwa Amoxiclav sikuti ndi mankhwala, koma madokotala amalimbikitsabe kusiya mtundu uliwonse wa mowa panthawi ya mankhwala othandizira.

  Amoxiclav 875 125. Ndemanga

  Alina: Chaka chathachi, mwana wamkazi kuchokera kumsasa wa ana adabwera ndi mphuno, yomwe idakula mwachangu, kenako kutentha. Mwa mankhwalawa, adotolo adalemba Amoxiclav. Nthawi zambiri pamikhalidwe yotere timatchulidwa Flemoxin solutab. Ndinadabwa, koma adotolo anafotokozera kuti Amoxiclav ndi watsopano kuposa Flemoxin ndipo ali ndi zochita zambiri. Sindinatsutsane, koma mapiritsiwo amatithandizadi.

  Marina: Nthawi zambiri ndimadwala, motero ndimamwa maantibayotiki. Koma kangapo ndimayenera kuchitira mwamuna wanga chimfine. Nthawi iliyonse, adotolo adatchula Amoxiclav. Sitingathe kuchita popanda zoyipa, m'mimba mwa amuna anga ndi ofooka, kotero ngakhale Linex sanasinthe. Koma matendawa amatha. Amuna anga sanakonde kuti mapiritsiwo ndi akulu mokwanira, sichabwino kutenga. Ndipo ena onse adakhutitsidwa, mwachangu komanso moyenera.

  Vyachedlav: Masika omaliza ndimakhala ndi zilonda zapakhosi. Nthawi zambiri ndimakhala nawo ndipo nthawi iliyonse ndimakhala oyera, nthawi yayitali.Zonsezi zadulidwa, zakonzedwa, chabwino, popanda maantibayotiki, nawonso, sangachite. Sindikusamala kuyesa mankhwala atsopano, koma Amokiklav atalembedwa kwa ine, amakayikira kuti chisangalalochi chimatuluka mtengo wotsika mtengo, pafupifupi ma ruble 500 pazinthu 14. Koma anagula. Chifukwa chake, koma nditatha masiku awiri kuchokera kummero wanga wapweteka pafupifupi palibe chotsalira. Kutentha kumatha, kuwukira pamtunda kwapita. Pakutha sabata, anali atachira.

  Amoxiclav ndi mankhwala omwe akatswiri amawaona ngati gulu la penicillin. Zomwe zikuluzikulu za mankhwalawa ndi amoxicillin ndi clavulanic acid. Ndi mankhwala atsopano yodziwika ndi kukhalapo kwa mphamvu yotsatsira. Ikagwiritsidwa ntchito, imapha mabakiteriya odziwika kwambiri omwe amalimbana ndi mankhwala ena omwe ali gawo la penicillin group pharmacological agents. Ndi mwayi uwu womwe umapereka kuchuluka kwa kugwiritsa ntchito mankhwalawa. Pogwiritsa ntchito maantibayotiki, matenda ambiri amatha kuthandizidwa.

  Pharmacological kanthu ndi zikuchokera

  Amoxiclav amadziwika ndi osiyanasiyana antimicrobialmachitidwe. Zimakuthandizani kuti muchotse bwino mabakiteriya a gramu-gramu komanso gram-negative m'thupi. Chofunikira chachikulu pakuphatikizidwa kwa mankhwalawa ndi amoxicillin.

  Mulinso mchere wa clavulanic acid. Kuphatikiza kuphatikiza zinthu izi kumatheka mphamvu machiritso. Kukhalapo kwa clavulanic acid kumapangitsa kukhalabe ndi antibacterial yambiri ya mankhwalawa panthawi ya mankhwala othandizira.

  The potaziyamu clavulanate omwe amapangidwa ndi wothandizirawa amathandizira kuti awononge mabakiteriya, omwe, akapatsidwa mankhwala, amayesa kupanga michere yoteteza - B-lactamases. Zochita za enzymeyi ndizotsekedwa ndi clavulanic acid. Komabe, kuwonjezera pa izi, zimasokoneza mabakiteriya, kuwononga makoma awo ndikupereka mphamvu yowonjezeranso tizilombo. Zotsatira zake, kugwiritsa ntchito mankhwalawa monga gawo la mankhwalawa kumathandizira kwambiri.

  Chithandizo chachikulu pakuchiritsika ndi wothandizirayi chimatheka chifukwa chakuti Amoxiclav ali ndi kuthekera kudziunjikira mumanyuzipepala amadzimadzi ndi ziwalo zathupi. Posakhalitsa, kuchuluka kwakukulu kwa mankhwala Amoxiclav kumachitika. Amakwanitsa kulowa mwachangu m'matumbo a ziwalo, komanso m'madzi a m'magazi, ngakhale atagwiritsa ntchito njira yotani poyambira. Pambuyo pa mphindi 60 kuchokera nthawi yomwe amamwa mankhwalawa, kupezeka kwa mankhwalawa m'mitsempha ndi m'magazi kumachitika.

  Kuchotsa kwa mankhwalawa m'njira yosasinthika kuchokera mthupi kumaperekedwa ndi impso. Cacululanic acid metabolites yaying'ono imatuluka ndi ndowe. Amasiyanso thupi limodzi ndi mpweya wotopa. Mankhwalawa samalowetsa ziwalo zaubongo, komanso kulowa mumadzi amkati mwa ubongo. Mbali iyi ya mankhwala imalola kuchepetsa chiopsezo kuwoneka kwa zoyipa zamagetsi chapakati pa mankhwalawa pakumwa mankhwalawa. Nthawi yomweyo, mukalandira chithandizo, mankhwala omwe amagwira ntchito mankhwalawa amatha kulowa m'matumbo, komanso amawonekera mkaka wa m'mawere.

  Pakalipano, wopanga mankhwalawa amapanga mitundu iyi:

  • mu mapiritsi okhala ndi filimu
  • mu mawonekedwe a ufa, cholinga chake chachikulu ndikupanga kuyimitsidwa,
  • mu mawonekedwe a lyophilized ufa, womwe umapangira jekeseni wamkati.

  Dziwani kuti musanagwiritse ntchito mankhwalawa ngati ufa, ayenera kuchepetsedwa m'madzi apadera - njira yothetsera. Kapenanso mutha kugwiritsa ntchito madzi osalala. Mitundu yonse ya Mlingo wa wothandizirayo tikambirana kwambiri.

  Amoxiclav mu mawonekedwe a mapiritsi ali ndi ndende yosiyanasiyana yogwira zinthu. Amaperekedwa m'makanema amitundu itatu:

  Kuphatikiza apo, mapiritsi a Amoxiclav pali zina zowonjezera zomwe zimapereka mapangidwe a mamasukidwe a mankhwala. Izi zikuphatikiza ndi magnesium stearate, silicon dioxide, komanso cellulose ndi citric acid. Mankhwala Amoxiclav mu mawonekedwe a mapiritsi musanayambe kugwiritsidwa ntchito amalimbikitsidwa kuti asungunuke m'madzi mu 100 ml. Ngati sizotheka kuchita izi, ndiye kuti muyenera kutafuna piritsi, kenako kumwa mankhwalawo ndi madzi okwanira.

  Amoxiclav mu mawonekedwe a ufa wopangidwira kukonzekera kuyimitsidwa amatengedwa pakamwa. Imapezeka m'mitundu itatu:

  • Amoxiclav 125. Kuphatikiza pa chinthu chachikulu yogwira amoxicillin, chomwe chili ndi 75 mg mu kukonzekera kumeneku, mumakhala mchere wa clavulanic acid wambiri 31.25 mg, woperekedwa mwa mawonekedwe a trihydrate,
  • Amoxiclav 250. Zomwe zimapangidwira ufa zimakhala ndi 250 mg ya antiotic komanso kuwonjezera mchere wamchere mu 62,5 mg,
  • Amoxiclav 400. Muli 400 mg ya amoxicillin ndi clavulanic acid mu 57 mg.

  Monga zowonjezera zina, chingamu, sodium saccharinate, silicon dioxide, ndi citric acid zilipo pakuyimitsidwa.

  Pokonzekera kuyimitsidwa, malangizo ogwiritsa ntchito amatsatiridwa. Ufa umasungunuka m'madzi oyenera. Botolo loti lisungunuke kwathunthu pazigawo limagwedezeka mwamphamvu.

  Ufa wothandizira kuti mtsempha wa magazi aziyamwa. Wopanga amapanga mitundu iwiri:

  • Amoxiclav 500. Zomwe zili muzinthu zazikulu zomwe zimagwira ntchito ndi 500 mg. Amawonetsedwa ngati mchere wa sodium. Kuphatikiza apo, mchere wa clavulanic acid mu mawonekedwe a mchere wa potaziyamu wa 100 mg ulipo.
  • Amoxiclav 1000. Muli amoxicillin mu kuchuluka kwa 1000 mg ndi 200 mg ya acid.

  Kwa jekeseni wamkati, kuyimitsidwa kumachitika ndi kupukuta ufa wowuma ndi madzi omwe amalowetsedwa kulowetsedwa. Mankhwala omalizidwa amapaka jekete kapena ndi dontho. Mankhwala akaperekedwa ndi njira ya ndege, amayesa kuyiyendetsa mu mtsempha pang'onopang'ono momwe mungathere. Izi zimathandizira kukwaniritsa mwachangu kwa njira yothandizira odwala, komanso zimathandizira kukonza mkhalidwe wa wodwalayo. Ngati pakufunika kukhudzana mosamala ndi mankhwalawo kwa nthawi yayitali, ndiye kuti kulowetsedwa kwa mankhwala kumachitika.

  Mankhwalawa ali ndi ma analogu ena omwe amalepheretsa ngati pakhale kuti palibe mu mankhwala:

  Mankhwala, mtengo wa Amoxiclav ufa umakhala pafupifupi 120 r. Mtengo wamapiritsi umatengera kuchuluka kwa zinthu zomwe zimagwira, komanso mawonekedwe a kumasulidwa. Pafupifupi, mtengo wamankhwala amtunduwu wamankhwala umasiyana 230 mpaka 450 p. pa paketi iliyonse.

  Zizindikiro zogwiritsidwa ntchito

  Akatswiri amapereka Amoxiclav pochiza matenda osiyanasiyana. Chida ichi chimathandiza kuthana bwino ndi zovuta zomwe zidayamba chifukwa cha mabakiteriya osagonjetsedwa ndi mankhwalawa. Mankhwalawa amalembera matenda otsatirawa:

  • matenda kupuma thirakiti
  • matenda a ziwalo za ENT zodwala,
  • matenda a kwamkodzo thirakiti
  • meningitis
  • sepsis.

  Zochita zachipatala zimawonetsa kuti yankho la wogwira mtima poletsa, komanso chithandizo cha matenda opatsirana a purulent-septic omwe amachitika pambuyo pa opareshoni, komanso matenda omwe amapatsirana pogonana.

  Malangizo ogwiritsira ntchito

  Kwa odwala omwe ali ndi matenda opatsirana, dokotala m'njira iliyonse amasankha mtundu wina wa mankhwala. Posankha Mlingo ndi nthawi yayitali ya maphunziro, katswiri amawunika zaka za wodwalayo, kuuma kwa matenda, komanso kupezeka kwamatenda oyamba. Kulemera kwa wodwala kumathandizidwanso. Kuthandizira kwamatenda, Amoxiclav iyenera kumwedwa ndi chakudya. Izi zimakuthandizani kuti muchepetse kuyipa kwa zotsatira zoyipa mukamamwa mankhwalawo.Wodwala akakonzekera kuyimitsidwa, ndiye kuti malingaliro omwe ali m'malangizo akuyenera kutsatiridwa.

  Malangizo ogwiritsira Amoxiclav mu piritsi

  Zochizira odwala ochepa azaka zopitilira 12 ndi thupi lolemera kuposa 40 kg, komanso achikulire, Amoxiclav 250 mg nthawi zambiri amakhazikitsidwa. Wodwala amatenga piritsi limodzi masana maola 8 aliwonse. Pa mankhwala ndi Amoxiclav 500 mg, mlingo wa mankhwalawa ndi katatu patsiku, piritsi limodzi. Kwa akulu omwe akulimbana ndi matenda oopsa, Amoxiclav 1000 mg ndi mankhwala. Wodwala ayenera kumwa piritsi limodzi kawiri pa tsiku. Kutalika kwa mankhwala ndi mankhwalawa piritsi kumasiyana masiku 5 mpaka 14. Ngati maantibayotiki agwiritsidwa ntchito kwanthawi yayitali, ndiye kuti mungakhumudwenso.

  Musanagwiritse ntchito piritsi la Amoxiclav, ndikofunikira kuti muyiyeretsa ndi theka kapu yamadzi. Zomwe zikuchokera zimayenera kusakanikirana. Pambuyo pokhapokha izi, izi zikuyenera kuledzera. Ngati palibe madzi pafupi, ndiye kuti piritsi liyenera kutafunidwa mosamala musanameze, kenako ndikusambitsidwa ndi madzi ambiri.

  Malangizo ogwiritsira ntchito Amoxiclav mu mawonekedwe a kuyimitsidwa

  Zochizira matenda omwe adadza mwa ana, Amoxiclav mu mawonekedwe a kuyimitsidwa amagwiritsidwa ntchito makamaka. Popereka mankhwala kwa ana akhanda ndi akhanda kuyambira zaka zitatu, mlingo uyenera kusankhidwa mosamala pakukhazikitsa mankhwalawa. Pofuna kutsogolera mlingo wa mankhwalawa panthawi ya mankhwala, supuni yoyezera imapezeka phukusi ndi mankhwalawo.

  Kwa ana okulirapo, mulingo chigono chimodzi. Mu malangizo omwe aphatikizidwa ndi mankhwalawa, mutha kupeza piritsi yapadera yomwe mutha kuwerengera moyenera mankhwalawa kwa mwana, kutengera kulemera kwake komanso msinkhu wake.

  Kugwiritsa ntchito bwino, mankhwalawa amayenera kumwedwa kawiri pa tsiku maola 12 aliwonse. Kapena mankhwalawa amatha kutha pambuyo pa maola 8 katatu patsiku. Dokotala amatha kudziwa kuchuluka kwa mankhwalawo, komanso kusankha mtundu woyenera wa mankhwalawo. Simuyenera kudzipangira nokha mankhwalawa, chifukwa kumwa mankhwalawo mosayenera kungayambitse matenda bongo. Ndipo izi zimakhala ndi zotsatirapo zoipa zaumoyo.

  Mankhwala akamwa mankhwala waukulu, izi zimatha kupezeka ndi vuto la kugaya chakudya m'mimba. Wodwala amatha kukumana ndi mavuto monga kupweteka kwam'mimba, kusanza, ndi kutsekula m'mimba. Kuda nkhawa ndiko njira yayikulu yowonetsera zamkati wamanjenje mukamamwa kwambiri Mlingo wa Amoxiclav.

  Kuphatikiza apo, kukhumudwa kwamanjenje kumachitika ndipo chisokonezo cha kugona chimachitika. Kugwedezeka kwamphamvu kumatha kuchitika kawirikawiri ndi mankhwala osokoneza bongo. Wodwala akakhala ndi zofanana ndi zake, chinthu choyamba kuchita ndikusamba m'mimba. Pambuyo pake, chinthu chabwino kwambiri chomwe mungachite ndikutenga kaboni yoyambitsa. Woopsa milandu, hemodialysis tikulimbikitsidwa.

  Mankhwala a Amoxiclav amaletsedwa motere:

  • ngati wodwala akumva chidwi ndi zinthu zomwe zimapanga mankhwala awa,
  • pamaso pa tsankho mankhwala okhudzana ndi penicillin osiyanasiyana a mankhwala ndi cephalosporins,
  • kuwonongeka kwa chiwindi ntchito, kupsa mtima chifukwa cha amoxicillin ndi clavulanic acid,
  • Pamaso pa lymphocytic leukemia kapena mononucleosis yachilengedwe.

  Matenda akulu a impso, komanso matenda am'mimba, ndi malire pazomwe zimatha kumwa mankhwalawa. Komanso, chithandizo chothandizira ndi wothandizira ichi sichikulimbikitsidwa ngati pali mbiri yolephera kwa chiwindi kapena pseudomembranous colitis. Mukamayamwa, simuyenera kuchita nawo mankhwalawa. Muyenera kufunsa dokotala yemwe payekhapayekha amatha kuganizira zovuta zomwe zilipo kuti asankhe mtundu wa mankhwala omwe angathandize wodwalayo kuti athetse matendawa mwachangu.

  Mankhwala a Amoxiclav pa nthawi yapakati

  Ndi osafunika kupereka Amoxiclav pa nthawi yochizira zochizira matenda opatsirana. Chowonadi ndi chakuti zinthu zofunikira zomwe zilipo pakupanga mankhwalawa zimatha kulowa m'chiberekero cha fetus popanda zovuta zilizonse, komanso, kupukusidwa mkaka wa m'mawere.

  Mbali iyi ya mankhwalawa imatha kupangitsa kuti kugwiritsa ntchito mankhwala oyembekezera kukhudza thanzi la mwana.

  Zochizira amayi apakati, mankhwalawa amagwiritsidwa ntchito molingana ndi mawonekedwe. Pa mankhwala, amachita mogwirizana ndi malangizo. Amalandira kwa amayi omwe ali ndi "mwayi wosangalatsa" pokhapokha ngati mankhwalawo atha kukhala ochuluka kuposa chiwopsezo chomwe chingaberekedwe kwa mwana wosabadwayo. Pazifukwa kuti pawiri yogwira mankhwalawa imadutsa mosavuta mkaka wa m'mawere, nthawi ya mkaka wa m'mawere, ngati pakufunika chithandizo, kuyamwitsa kumayimitsidwa ndikudyetsedwa pazosakaniza zowonekera.

  Madokotala akasankha mankhwala monga Amoxiclav pochiza matenda, wodwalayo amatha kupeza zotsatirazi:

  • Kuperewera kwa chakudya, nseru. Kuphatikiza apo, Zizindikiro zomwe zimayambitsa matenda monga colitis, gastritis, ndi khungu la enamel ya mano zimatha kuchitika. Kuwonongeka kwa chiwindi chatsimikizika mu milandu. Kusintha kwa kuchuluka kwa magazi kumatha kuonekeranso, zizindikiro zokhudzana ndi kuchepa kwa chiwindi, chiwindi chimatha. Ndikofunika kudziwa kuti zoyipa zimakonda kupezeka kwa odwala atakalamba.
  • Mutu, chizungulire komanso kusowa tulo. Hyperacaction kapena kusachita bwino kwa wodwala yemwe akutenga Amoxiclav zitha kuwonekeranso. Matenda okomoka amatha kuchitika kwa odwala omwe ali ndi matenda a impso ngati Amoxiclav atengedwa waukulu.
  • thrombocytopenia, thrombocytosis,
  • kuyabwa, kuwoneka kwa poizoni wa epidermal necrolysis.

  Amoxiclav imatengedwa nthawi yayitali, ndizotheka chiopsezo cha malungo.

  Ndikofunika kudziwa kuti zomwe zimatchulidwa pamwambapa zimachitika pakumwa mankhwalawa kapena mukangomaliza chithandizo. Zochitika zonse zosasangalatsa zimasinthidwa, komabe, kuwonongeka kwa chiwindi kungakhale kwambiri. Amapezeka makamaka mwa odwala omwe ali ndi chiwindi, kapena amayamba chifukwa cha kumwa mankhwala a hepatoxic.

  Kuchita ndi mankhwala ena?

  Sitikulimbikitsidwa kumwa mankhwalawa nthawi imodzi ndi anticoagulants. Chithandizo chovuta choterechi chimatha kupatsa magazi wodwala. Pogwiritsa ntchito mankhwalawa limodzi ndi rifampicin, mphamvu ya antibacterial ya Amoxiclav imafooka, popeza mankhwalawa otsutsa.

  Simungathe kupereka mankhwalawa nthawi imodzi ngati macrolides. Sikulimbikitsidwa kuti muziphatikiza ndi zovuta mankhwala othandizira ndi tetracyclines. Kuphatikiza kwa mankhwalawa kumabweretsa kuchepa kwa kuchiritsika kwa mankhwalawa. Amoxiclav akamwedwa ndi maantibayotiki, mphamvu ya mankhwalawa monga mapiritsi imachepa.

  Amoxiclav ndi mankhwala omwe ali m'gulu la mankhwala a penicillin. Itha kugwiritsidwa ntchito pochiza matenda osiyanasiyana. Mankhwalawa ali ndi mphamvu yothandizira antibacterial, yomwe imakuthandizani kuti muchotse wodwala matenda omwe abwera. Chida ichi chimapezeka m'mafakitale osiyanasiyana.

  Amamasulidwa mu mawonekedwe a mapiritsi, ufa.Kuchiza matenda kumachitika mwa ana ndi akulu. Mwachilengedwe, kuchuluka kwa mankhwalawa kwa mitundu iyi ya odwala kumasiyana. Pa nthawi yoyembekezera, mankhwalawa ali osavomerezeka. Kuphwanya kumeneku kumalumikizidwa, choyambirira, ndi chakuti zigawo zomwe zili mu mankhwalawa zimalowa mosavuta m'matumbo ndi mkaka wa m'mawere. Chifukwa chake, tikulimbikitsidwa kuchiza matenda opatsirana panthawi yoyembekezera mothandizidwa ndi njira zina.

  Panthawi yodyetsa, ndikofunikira kusiya kuyamwitsa ndikusamutsira chakudya ndi zosakaniza zopanga. Sitikulimbikitsidwa kudzipangira payekha chithandizo ndi Amoxiclav (mapiritsi), popeza kusankha kolakwika kwa mankhwalawa kungayambitse mavuto azaumoyo. Zikatero, ndikofunikira kutsuka m'mimba ndikuyamwa makala.

  Amoxiclav Quicktab - mankhwala opanga ma penicillin osokoneza bongo a gulu la penicillin osakanikirana ndi β-lactamase inhibitors.

  Kutulutsa mawonekedwe ndi kapangidwe kake

  Mankhwala amapezeka mu mawonekedwe a mapiritsi omaliza:

  • Mlingo wa 500 + 125 mg ndi 875 + 125 mg: mapiritsi a octagonal, owala, achikasu owoneka ndi ma bulauni, amakhala ndi fungo labwino la zipatso (ma PC 2. m'matuza, paketi ya makatoni 5 kapena 7 matuza),
  • Mlingo wa 125 + 31.3 ndi 250 + 62.5: mapiritsi ndi ozungulira, mapangidwe omwenso ali ndi mbali zonse, akulemba "SN57" mbali imodzi, utoto kuyambira wachikasu mpaka wachikasu, wokhala ndi matuza a bulauni (ma 2 ma PC. mu paketi okhala ndi makatoni 5, 7 kapena 10).

  Muli piritsi limodzi la mapiritsi a 500 + 125 mg ndi 875 + 125 mg:

  • yogwira zinthu: amoxicillin - 500/800 mg, clavulanic acid - 125 mg (mu mawonekedwe a amoxicillin trihydrate - 574 / 1004.5 mg ndi potaziyamu clavulanate - 148.87 mg),
  • magawo othandizira: mapira, talc, zonunkhira, chisakanizo chazotentha ndi lalanje wokoma, anhydrous colloidal silicon dioxide, chikasu chachitsulo oxide (E172), mafuta a castor hydrogenated, microcrystalline silicon-cellulose.

  Muli piritsi limodzi la mapiritsi a 125 + 31.3 ndi 250 + 62.5:

  • yogwira zinthu: amoxicillin - 125/250 mg, clavulanic acid - 31.3 / 62,5 mg (mu mawonekedwe a amoxicillin trihydrate - 143.5 / 287 mg ndi potaziyamu clavulanate - 37.2 / 74.4 mg),
  • magawo othandizira: silicon dioksidi, crospovidone, kukoma kwa lalanje

  Mankhwala

  Limagwirira ntchito Amoxiclav Quiktab ndi chifukwa cha kuphatikiza zigawo zina zomwe zimapangidwa:

  • amoxicillin ndi anti-spectrum semisynthetotic antiotic womwe umagwira motsutsana ndi ma gram angapo opanda gram komanso opanda gramu, chifukwa chakuwonongeka kwake kwa chiwonongeko cha β-lactamases, chiwonetsero cha ntchito ya amoxicillin amangokhala pazinthu zazing'ono zomwe zimapanga enzyme iyi,
  • clavulanic acid, β-lactamase inhibitor mogwirizana ndi penicillins, kupanga macephalosporins osiyanasiyana ndi penicillins omwe amalimbana ndi ma β lactamases omwe amapezeka kawirikawiri amachititsa kuti tizilombo toyambitsa matenda tizilombo toyambitsa matenda tizilombo toyambitsa matenda tizilombo toyambitsa matenda tizilombo toyambitsa matenda tizilombo toyambitsa matenda, timene timayambitsa kukana kwa mabakiteriya, koma timalephera motsutsana ndi chromosomal β mtundu. Kupezeka kwa clavulanic acid pakukonzekera kumateteza amoxicillin ku chiwonongeko cha β-lactamases, kuilola kuti iwonjezeke mawonekedwe ake a antibacterial.

  Amoxicillin osakanikirana ndi clavulanic acid amagwira ntchito motsutsana ndi microflora yotsatira ya pathogenic:

  Tizilombo tating'onoting'ono ta a grobic: Streptococcus pneumoniae, Streptococcus vir> Pharmacokinetics

  Magawo ofunikira a pharmacokinetic a zigawo zogwira ntchito za Amoxiclav Quiktab (amoxicillin ndi clavulanic acid) ndi ofanana:

  • mayamwidwe: pambuyo pakamwa makonzedwe, mankhwala bwino odzipereka kwa m'mimba thirakiti (GIT), kuchuluka kwa mayamwidwe sizimadalira chakudya.The bioavailability wa amoxicillin ndi 90%, clavulanic acid ndi 70%, kuchuluka kwa plasma ndende (Cmax) kumatheka 1 ora pambuyo makonzedwe ndipo zimasiyana kutengera mlingo: amoxicillin - kuyambira 3 mpaka 12 μg / ml, clavulanic acid - pafupifupi 2 μg / ml. Hafu ya moyo (T1 / 2): amoxicillin - 78 min, clavulanic acid - 60-70 min,
  • kufalitsa: zinthu zonse zogwira zimagawidwa bwino m'madzi ndi minyewa, kulowa mkati mwa madzi, sinus, mapapu, kutulutsa kwamkati, zotupa za m'mimba, mazira, chiberekero, chiwindi, minofu , Prostate, madzimadzi a peritoneal, kuchuluka kwa mankhwala amalembedwa mkodzo. Ndi maninges osagwiritsidwa ntchito, amoxicillin ndi clavulanic acid sangathe kulowa mu magazi otchinga magazi (BBB). Koma amadutsa mozungulira chotchinga ndipo amachotseredwa mkaka wa m'mawere m'kulondola. Mlingo womangidwa wa amoxiclav ku mapuloteni a plasma ndi wotsika,
  • amoxicillin amakhala ndi gawo pang'ono kagayidwe, clavulanic acid limapangidwa mwamphamvu,
  • chimbudzi: amoxicillin imachotsedwa ndi katulutsidwe katulutsidwe ndi kusefukira kwa impso, pafupifupi kosasinthika, clavulanic acid mwa kusefera kwa glomerular, ena mwa ma metabolites. Mwapang'onopang'ono, zinthu zimatha kupukusidwa kudzera m'mapapu ndi matumbo. T1 / 2 Amoxiclav Quicktab mwa okalamba ndi pafupifupi ola limodzi.

  Odwala omwe amalephera kwambiri aimpso, T1 / 2 imawonjezeka mpaka maola 7.5 a amoxicillin ndi maola 4.5 a clavulanic acid.

  Zinthu zonse zomwe zimagwiritsidwa ntchito zimachotsedwa pa hemodialysis ndipo zazing'ono zimatulutsidwa panthawi ya diitosis ya peritoneal.

  Zizindikiro zogwiritsidwa ntchito

  Malinga ndi malangizo, Amoxiclav Quicktab akulimbikitsidwa pochiza matenda opatsirana komanso otupa omwe amayambitsidwa ndi tizilombo tating'ono tomwe timayamwa ndi mankhwala, izi:

  • chapamwamba kupuma thirakiti ndi ENT ziwalo: pachimake / aakulu sinusitis, pachimake / aakulu otitis media, pharyngitis, pharyngeal abscess, tonsillitis, etc.
  • m'munsi kupuma thirakiti: bronchitis, bronchitis pachimake ndi bakiteriya wamphamvu, chibayo, etc.,
  • kwamkodzo thirakiti: urethritis, cystitis, pyelonephritis, etc.,
  • khungu ndi zofewa (kuphatikiza kulumidwa kwa anthu ndi nyama),
  • minofu yofupa ndi yolumikizana: osteomyelitis,
  • Biliary thirakiti: cholecystitis, cholangitis,
  • pamlomo wamkamwa (zotupa za odontogenic).

  Amoxiclav Quicktab imagwiritsidwanso ntchito muzochita zachipembedzo ndi mchitidwe wothandizira.

  • Ana osakwana zaka 12
  • kulemera kwa thupi mpaka 40 kg
  • Zambiri zamankhwala am'mimba za cholestatic jaundice kapena /
  • Zambiri zamankhwala okhudzana ndi ma hypersensitivity amtundu uliwonse wa mankhwala opezeka ku gulu la penicillin, cephalosporins, mankhwala ena a β-lactam,
  • Hypersensitivity ku zilizonse za mankhwala.

  Mosamala, Amoxiclav Quiktab iyenera kugwiritsidwa ntchito ndi mbiri ya pseudomembranous colitis, kulephera kwa chiwindi, kusokonezeka kwambiri kwa impso komanso panthawi yoyamwitsa.

  Popeza mwa odwala ambiri omwe ali ndi matenda opatsirana a mononucleosis ndi lymphocytic leukemia, zotupa za erythematic zimawonedwa pa mankhwala ampicillin, osavomerezeka kupereka mankhwala a gulu la ampicillin.

  Malangizo ogwiritsira ntchito Amoxiclav Quicktab: njira ndi mlingo

  Mapiritsi a Amoxiclav Quiktab amatengedwa pakamwa, omwe kale amasungunuka kapu imodzi ya madzi (osachepera 30 ml) ndi kusakaniza bwino. Mutha kusunga piritsi pakamwa panu mpaka atasungunuka kwathunthu, kenako ndikumeza.

  Ndi bwino kumwa mankhwalawa musanadye chakudya kuti muchepetse zovuta zoyambira m'mimba.

  Mlingo woyenera wa odwala ndi ana opitirira zaka 12 (okhala ndi kulemera kwa thupi woposa makilogalamu 40):

  • Matenda ofatsa kapena ochepa: piritsi limodzi la Amoxiclav Quiktab 500 + 125 mg maola 12 aliwonse,
  • kwambiri matenda ndi kuwonongeka kwa kupuma thirakiti: piritsi 1 la Amoxiclav Quicktab 875 + 125 mg maola 12 aliwonse kapena piritsi limodzi la Amoxiclav Quicktab 500 + 125 mg maola 8 aliwonse.

  Kutalika kwa chithandizo mpaka milungu iwiri.

  Ngati mankhwala adayamba ndi kholo la makulidwe a amoxicillin ndi clavulanic acid, ndiye kuti mukuyenera kusintha kuti mutenge mapiritsi a Amoxiclav Quiktab mkati.

  Zotsatira zoyipa chifukwa cha mankhwala ndi Amoxiclav Quiktab mbali ya machitidwe ndi ziwalo (makamaka zofooka komanso zosakhalitsa):

  • kugaya chakudya, kusanza, kusanza, kutsegula m'mimba, kawirikawiri - kuchuluka kwa michere ya hepatic: alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) ndi mkhutu wa hepatic, munthawi zina - hepatitis, cholestatic ,
  • pakati mantha dongosolo (CNS): chizungulire, kupweteka mutu, kawirikawiri - kupweteka (nthawi zambiri ndi mkhutu aimpso ntchito limodzi ndi kumwa kwambiri Mlingo).
  • hematopoietic dongosolo: kawirikawiri - kusinthika kwa leukopenia (kuphatikizapo neutropenia), thrombocytopenia, chosowa kwambiri - hemolytic anemia, kuchuluka kosintha kwa prothrombin nthawi (ngati amagwiritsidwa ntchito limodzi ndi anticoagulants),
  • kwamikodzo: chosowa kwambiri - crystalluria, interstitial nephritis,
  • Hypersensitivity zimachitika: pruritus, erythematous zidzolo, urticaria, kawirikawiri - angioedema, multiforme exudative erythema, anaphylactic mantha, matupi awo a vasculitis, nthawi zina - Stevens-Johnson syndrome, exermative dermatitis, poyizoni epidermal necrolysis ,
  • zotulukapo zina: kawirikawiri - kukhazikitsidwa kwa kupambana kwamphamvu (kuphatikizapo candidiasis).

  Zambiri pazotsatira zoyipa kapena kufa chifukwa cha mankhwala osokoneza bongo a Amoxiclav Quicktab sizinalembedwe.

  Zizindikiro za bongo ndi kusokonezeka kwam'mimba: kupweteka kwam'mimba, kutsegula m'mimba / kusanza, kusowa tulo, kuda nkhawa, chizungulire ndizothekanso, munthawi zina - kukomoka mwamphamvu.

  Chithandizo cha mankhwala chimayikidwa, mutatenga magawo (ndi makonzedwe aposachedwa a mapiritsi, osapitilira maola 4) kuti muchepetse kuyamwa kwa mankhwalawa - kupweteka kwa m'mimba ndi kugwiritsa ntchito makala oyambitsa. Amoxicillin ndi clavulanic acid amachotsedwa pa hemodialysis. Wodwala amafunika kuti ayang'anire kuchipatala.

  Mukachepetsa kuthamanga kwa magazi, wodwalayo ayenera kutenga malo a Trendelenburg - atagona kumbuyo kwanu, kwezani pelvis molingana ndi mutu pakona pa 45 °.

  Munthawi ya mankhwala, kuwongolera ntchito ya chiwindi, impso ndi hematopoiesis kumafunika.

  Mukuwonongeka kwambiri kwa aimpso, kusintha kosiyanasiyana kwa mankhwalawa kapena kuwonjezeka pakatikati pa Mlingo wake ndikofunikira.

  Pochita mankhwala ndi Amoxiclav Quicktab, njira yonyenga imatheka chifukwa chogwiritsidwa ntchito ndi Benedict's reagent kapena Felling solution kuti mupeze kuchuluka kwa shuga mumkodzo, chifukwa chake, enzymatic reaction ndi glucosidase tikulimbikitsidwa.

  Kukopa pa kuthekera koyendetsa magalimoto ndi njira zowerengeka

  Zambiri pazotsatira zoyipa za Amoxiclav Quiktab zotengedwa mu Mlingo woyenera kuthamanga kwa psychophysical reaction komanso kuthekera kwatsatanetsatane sizinanene.

  Mimba komanso kuyamwa

  Amoxiclav Quiktab amaloledwa kugwiritsidwa ntchito panthawi yoyembekezera komanso kuyamwa (ngati yoyamwitsa) ngati pali zidziwitso zomveka bwino pamene maubwino omwe akuyembekezeredwa kwa mayi amapitilira chiwopsezo cha mwana wosabadwayo / mwana.

  Gwiritsani ntchito paubwana

  Muzochita za ana, amalephera kupereka mankhwala ochizira ana osaposa zaka 12 ndi / kapena kulemera kwa thupi mpaka 40 makilogalamu.

  Ndi mkhutu aimpso ntchito

  Mlingo wa Amoxiclav Kviktab umasinthidwa m'njira yochepetsera mlingo kapena kukulitsa nthawi pakati pa Mlingo mogwirizana ndi kuopsa kwa kupezeka kwa impso:

  • kulephera kwapakati mwamphamvu ndi creatinine chilolezo (CC) kuyambira 10 mpaka 30 ml / mphindi: piritsi 1 (500 + 125 mg) maola 12 aliwonse,
  • kulephera kwambiri kwaimpso ndi CC zosakwana 10 ml / min: piritsi 1 (500 + 125 mg) maola 24 aliwonse.

  Mu anuria, nthawi yapakati pakati Mlingo uyenera kuchuluka mpaka maola 48 kapena kuposerapo.

  Chenjezo limalimbikitsidwa kwa odwala omwe ali ndi vuto laimpso pakumwa mankhwala.

  Ndi chiwindi ntchito

  Kusamala ndikulimbikitsidwa odwala hepatic osakwanira pamene Amoxiclav Quiktab.

  • Maantacid, glucosamine, mankhwala ofewetsa tuvi tolimba, aminoglycosides: kuchepa mayamwidwe a Amoxiclav Quicktab,
  • ascorbic acid: amachulukitsa kuyamwa kwa amoxicillin ndi clavulanic acid,
  • diuretics, allopurinol, phenylbutazone, mankhwala osapinga a antiidal
  • methotrexate: Amoxiclav Quicktab imathandizira poizoni wake,
  • allopurinol: mankhwalawa amawonjezera zomwe zimachitika exanthema,
  • disulfiram: pewani mgwirizano ndi Amoxiclav Quiktab,
  • Mankhwala a anticoagulant: popeza Amoxiclav Quiktab nthawi zina amatha kutalikitsa nthawi ya prothrombin, kusamala kuyenera kugwiritsidwa ntchito nthawi yomweyo.
  • rifampicin: Ndiwotsutsana wa amoxicillin wokhala ndi kufooka kwa antibacterial ogwira,
  • mankhwala opatsirana a bacteriostatic (macrolides, tetracyclines), sulfonamides: Amoxiclav Quiktab ayenera kugwiritsidwa ntchito maola angapo asanatengedwe,
  • phenenecid: linalake ndipo tikulephera kuphipha kwa amoxicillin, kukulitsa kuchuluka kwake kwa seramu,
  • njira zakulera pakamwa: Amoxiclav Quicktab amachepetsa kugwira ntchito kwawo.

  Anoxiclav Quiktab analogues akuphatikizapo Amoxivan, Amovicomb, Amoxicillin + Clavulanic acid, Amoxiclav, Arlet, Augmentin, Betaclav, Bactoclav, Verclav, Medoclav, Clamosar, Novaclav, Panclav 2X, Rapiclav, Ranklav, Flemoclav Soloktab, Dr.

  Migwirizano ndi machitidwe osungidwa

  Sungani pamalo owuma pamatenthedwe mpaka 25 ° C. Pewani kufikira ana.

  Moyo wa alumali ndi zaka 2.

  Mankhwala Okhala Pamalo a Pharmacy

  Yoperekedwa ndi mankhwala.

  Ndemanga za Amoxiclav Quiktab

  Malinga ndi ndemanga, Amoxiclav Quicktab ndi mankhwala othandizira omwe amathandizira matenda osiyanasiyana. Odwala ambiri amakonda kukoma kwa mapiritsi osungunuka ndipo owerengeka okha amawatcha osasangalatsa. Kutheka kugwiritsa ntchito mankhwalawa panthawi yapakati komanso panthawi yoyamwitsa kumadziwika kuti ndi mwayi wabwino. Kutsimikizika kwapadera pakuwunika kumaperekedwa pakufunika kotsatira malangizo azachipatala akamamwa mapiritsi.

  Ambiri mwa odwala nthawi zambiri amaganiza kuti mtengo wa mankhwalawo ndiye chinthu chachikulu chomwe ungabwezere.

  Mtengo wa Amoxiclav Quicktab m'masitolo ogulitsa mankhwala

  Mtengo wa Amoxiclav Quiktab mwanjira ya mapiritsi a 500 + 125 mg, 14 ma PC. mu phukusi - 388 ma ruble. Mapiritsi a Amoxiclav Quicktab 875 + 125 mg amatenga ma ruble 430.

  MALANGIZO
  pa kugwiritsa ntchito mankhwalawa
  ntchito zamankhwala

  Werengani malangizo awa mosamala musanayambe kumwa / kugwiritsa ntchito mankhwalawa.
  Sungani bukuli, lingafunenso.
  • Ngati muli ndi mafunso, funsani dokotala.
  • Mankhwalawa amaperekedwa kwa inu panokha ndipo sayenera kugawana ndi ena, popeza amathanso kuwavulaza ngakhale mutakhala ndi zofanana ndi inu.

  Mlingo

  Mapiritsi okhala ndi mafilimu

  Zinthu zogwira ntchito (pachimake): piritsi lililonse la 250 mg + 125 mg lili ndi 250 mg ya amoxicillin mu mawonekedwe a trihydrate ndi 125 mg ya clavulanic acid mu mawonekedwe a mchere wa potaziyamu,
  piritsi lililonse la 500mg + 125mg lili ndi 500 mg ya amoxicillin mu mawonekedwe a trihydrate ndi 125 mg ya clavulanic acid mu mawonekedwe a mchere wa potaziyamu,
  piritsi lililonse la 875 mg + 125 mg limakhala ndi 875 mg ya amoxicillin mu mawonekedwe a trihydrate ndi 125 mg ya clavulanic acid momwe amapangira mchere wa potaziyamu.
  Omwe amaperekera (mulingo uliwonse): colloidal silicon dioxide 5.40 mg / 9.00 mg / 12,00 mg, crospovidone 27.40 mg / 45.00 mg / 61.00 mg, croscarmellose sodium 27.40 mg / 35.00 mg / 47.00, magnesium stearate 12,00 mg / 20,00 mg / 17.22 mg, talc 13.40 mg (kwa Mlingo 250 mg + 125 mg), cellcose ya microcrystalline mpaka 650 mg / mpaka 1060 mg / mm 1435 mg
  makanema othandizira mafilimu 250mg + 125mg - hypromellose 14.378 mg, ethyl cellulose 0.702 mg, polysorbate 80 - 0,780 mg, triethyl citrate 0,793 mg, titanium dioxide 7.605 mg, talc 1.742 mg,
  makanema othandizira mafilimu 500 mg + 125 mg - hypromellose 17.696 mg, ethyl cellulose 0,864 mg, polysorbate 80 - 0,960 mg, triethyl citrate 0.976 mg, titanium dioxide 9,360 mg, talc 2.144 mg,
  makanema othandizira mafilimu 875 mg + 125 mg - hypromellose 23.226 mg, ethyl cellulose 1.134 mg, polysorbate 80 - 1.260 mg, triethyl citrate 1.280 mg, titanium dioxide 12.286 mg, talc 2.814 mg.

  Kufotokozera

  Mapiritsi a 250 mg + 125 mg: oyera kapena pafupifupi oyera, oblong, octagonal, biconvex, mapiritsi okhala ndi mafilimu okhala ndi ma Prints 250/25 mbali imodzi ndi AMC mbali inayo.
  Mapiritsi 500 mg + 125 mg: oyera kapena pafupifupi oyera, oval, mapiritsi a biconvex, filimu yokutira.
  Mapiritsi a 875 mg + 125 mg: oyera kapena pafupifupi oyera, oblong, biconvex, mapiritsi okhala ndi mafilimu okhala ndi notch komanso chithunzi cha "875/125" mbali imodzi ndi "AMC" mbali inayo.
  Onani pa kink: misa yachikasu.

  Mankhwala

  Mankhwala
  Njira yamachitidwe
  Amoxicillin ndi penicillin wopanga yemwe amagwira ntchito motsutsana ndi michere yambiri yama gramu-gram komanso yoyipa. Amoxicillin amasokoneza biosynthesis ya peptidoglycan, yomwe ndi gawo lachipangidwe cha khoma la bakiteriya. Kuphwanya kapangidwe ka peptidoglycan kumabweretsa kuwonongeka kwa mphamvu ya khungu, komwe kumayambitsa lasis ndi kufa kwama cellorganism. Nthawi yomweyo, amoxicillin imayamba kuwonongeka ndi beta-lactamases, chifukwa chake ntchito yokhala ndi amoxicillin sinafikira tizilombo tomwe timatulutsa timadzi tambiri.
  Clavulanic acid, beta-lactamase inhibitor yokhudzana ndi penicillin, amatha kuyambitsa mitundu yambiri ya beta-lactamases yomwe imapezeka mu penicillin ndi cephalosporin zosagwira tizilombo. Clavulanic acid ili ndi mphamvu yokwanira yolimbana ndi plasmid beta-lactamases, yomwe nthawi zambiri imayambitsa kukokana kwa bakiteriya, ndipo siigwira ntchito motsutsana ndi mtundu I chromosome beta-lactamases, womwe suletsedwa ndi clavulanic acid.
  Kupezeka kwa clavulanic acid pakukonzekera kumateteza amoxicillin kuti asawonongeke ndi ma enzymes - beta-lactamases, omwe amalola kukulitsa mawonekedwe a antibacterial a amoxicillin.
  Otsatirawa ndi ntchito ya vitro yosakanikirana ya amoxicillin ndi clavulanic acid.

  Bacteria imakonda kuphatikizidwa ndi amoxicillin ndi clavulanic acid

  Ma gror-positive aerobes: Bacillus anthracis, Enterococcus faecalis, Listeria monocytogene, Nocardia asteroides, Streptococcus pyogenes ndi ena a beta-hemolytic streptococci1,2, Streptococcus agalactiae1,2, streycoccus aalus (tcheru ndi methicillin). Ma gror-negative aerobes: Bordetella pertussis, Haemophilus influenzae1, Helicobacter pylori, Moraxella catarrhalis1, Neisseria gonorrhoeae, Pasteurella multocida, Vibrio cholerae. Ena: Borrelia burgdorferi, Leptospira icterohaemorrhagiae, Treponema pallidum. Ma anaerobes a gramu: mitundu ya mtundu wa Clostridium, Peptococcus niger, Peptostreptococcus magnus, Peptostreptococcus micros, mitundu ya genus Peptostreptococcus. Ma gram alibe ana Bacteroides fragilis, mitundu ya mtundu wa Bacteroides, mitundu ya mtundu wa Capnocytophaga, Eikenella corrodens, Fusobacterium nucleatum, mitundu ya genus Fusobacterium, mitundu ya genus Porphyromonas, mitundu ya genus Prevotella.

  Bacteria yemwe wakwanitsa kupewa kuphatikiza kwa amoxicillin ndi clavulanic acid

  Mitundu ya grram-negative aerobes: Escherichia coli1, Klebsiella oxytoca, Klebsiella pneumoniae, mitundu ya mtundu wa Klebsiella, Proteus mirabilis, Proteus vulgaris, mitundu ya mtundu wa Proteus, mitundu ya mtundu wa Salmonella, mitundu ya mtundu wa Shigella. Ma gror-positive aerobes: mitundu ya genus Corynebacterium, Enterosocus faecium, Streptococcus pneumoniae1,2, streptococci of the Viridans group.

  Bacteria Wotsutsana Mwachilengedwe kuphatikiza kwa amoxicillin ndi clavulanic acid

  Mitundu ya grram-negative aerobes: mitundu ya genus Acinetobacter, Citrobacter freundii, mitundu ya genus Enterobacter, Hafnia alvei, Legionella pneumophila, Morganella morganii, mitundu ya genus Pseudomonas, mitundu ya genus Serratia, Stenotrophomonas maligaia. Zina: Chlamydophila pneumoniae, Chlamydophila psittaci, mitundu ya genus Chlamydia, Coxiella burnetii, mitundu ya mtundu wa Mycoplasma. 1 mwa mabakiteriya, mphamvu ya kuphatikiza kwa kuphatikizika kwa amoxicillin ndi clavulanic acid yawonetsedwa mu maphunziro azachipatala. Mitundu iwiri ya mabakiteriya satulutsa beta-lactamases. Kuzindikira ndi amoxicillin monotherapy kumasonyezanso chidwi chofanana ndi kuphatikiza kwa amoxicillin ndi clavulanic acid.

  Pharmacokinetics
  Magawo akuluakulu a pharmacokinetic a amoxicillin ndi clavulanic acid ndi ofanana. Amoxicillin ndi clavulanic acid amasungunuka bwino m'mayankho amadzimadzi ndi pH yamoyo pH ndipo atatenga Amoxiclav® mkati, amatha mwachangu komanso kwathunthu kuchokera m'matumbo am'mimba (GIT). Kuyamwa kwa yogwira zinthu za amoxicillin ndi clavulanic acid ndi bwino ngati amamwa kumayambiriro kwa chakudya.
  The bioavailability wa amoxicillin ndi clavulanic acid pambuyo pakamwa makonzedwe ali pafupifupi 70%.
  Ma paracokinetic magawo a amoxicillin ndi clavulanic acid amaperekedwa pansipa pambuyo pa utsogoleri wa 875 mg / 125 mg ndi 500 mg / 125 mg kawiri patsiku, 250 mg / 125 mg katatu patsiku ndi odzipereka athanzi.

  Pakati (± SD) pharmacokinetic parameter
  Kuchita chinthu Amoxicillin / clavulanic acid	Osakwatiwa Mlingo (mg)	Cmax (mcg / ml)	Tmax (ola)	AUC (0-24h) (mcg.h / ml)	T1 / 2 (ola)
  Amoxicillin
  875 mg / 125 mg	875	11,64±2,78	1.50 (1.0-2.5)	53,52±12,31	1.19±0.21
  500 mg / 125 mg	500	7,19±2,26	1.50 (1.0-2.5)	53,5±8,87	1.15±0.20
  250 mg / 125 mg	250	3,3±1,12	1,5 (1,0-2,0)	26,7±4,56	1,36±0,56
  Clavulanic acid
  875 mg / 125 mg	125	2,18±0,99	1.25 (1.0-2.0)	10,16±3,04	0.96±0.12
  500 mg / 125 mg	125	2,40±0,83	1.5 (1.0-2.0)	15,72±3,86	0.98±0.12
  250 mg / 125 mg	125	1,5±0,70	1,2 (1,0-2,0)	12,6±3,25	1.01±0,11

  Сmax - kuchuluka kwa plasma ndende,

  Tmax - nthawi yoti mufikire kuchuluka kwa plasma,

  AUC ndi malo omwe amaponderezedwa "nthawi yayitali",

  T1 / 2 - theka moyo

  Kugawa
  Onsewa amakhala ndi kuchuluka kwabwino kugawa zosiyanasiyana ziwalo, zimakhala ndi zamadzimadzi (kuphatikiza m'mapapo, ziwalo zam'mimbamo zam'mimba, adipose, mafupa ndi minofu minofu, pleural, synovial ndi peritoneal fluid, pakhungu, bile, mkodzo, mafinya kumaliseche, sputum, mu madzi mkati.
  Kumanga mapuloteni a Plasma ndiwofatsa: 25% ya clavulanic acid ndi 18% ya amoxicillin.
  Voliyumu yogawa ndi pafupifupi 0.3-0.4 L / kg ya amoxicillin ndi pafupifupi 0,2 L / kg ya clavulanic acid.
  Amoxicillin ndi clavulanic acid samadutsa chotchinga magazi mu maukonde osavulala.
  Amoxicillin (monga ma penicillin ambiri) amathandizidwa mkaka wa m'mawere. Zotsatira za clavulanic acid zapezekanso mkaka wa m'mawere. Amoxicillin ndi clavulanic acid amawoloka placental zotchinga.
  Kupenda
  Pafupifupi 10-25% ya koyamba mlingo wa amoxicillin umatheka ndi impso mu mawonekedwe a penicilloic acid osagwira. Clavulanic acid m'thupi la munthu imadwala kwambiri mapangidwe a 2,5-dihydro-4- (2-hydroxyethyl) -5-oxo-1H-pyrrole-3-carboxylic acid ndi 1-amino-4-hydroxy-butan-2-one ndikufotokozedwanso ndi impso, kudzera m'mimba, komanso ndi mpweya wotulutsidwa, ngati mpweya wa kaboni.
  Kuswana
  Amoxicillin amachotseredwa makamaka ndi impso, pomwe clavulanic acid kudzera munthawi yonse yaimpso ndi zowonjezera. Pambuyo pakamwa limodzi lokha piritsi limodzi, 250 mg / 125 mg kapena 500 mg / 125 mg, pafupifupi 60-70% ya amoxicillin ndi 40-65% ya clavulanic acid amawonetsedwa ndi impso m'masiku 6 oyamba.
  Pafupifupi theka la moyo (T1 / 2) wa amoxicillin / clavulanic acid ndi pafupifupi ola limodzi; kuvomerezeka kwathunthu kumakhala pafupifupi 25 l / h kwa odwala athanzi.
  Kuchuluka kwa asidi wa clavulanic kumakhudzidwa nthawi yoyamba ya 2 pambuyo pa ntchito.
  Odwala ndi mkhutu aimpso ntchito
  Chilolezo chonse cha amoxicillin / clavulanic acid chimachepera mogwirizana ndi kuchepa kwa impso. Chilolezo chocheperako chimatchulidwa kuti amoxicillin kuposa clavulanic acid, chifukwa ambiri a amoxicillin amamuchotsa impso. Mlingo wa mankhwala aimpso kulephera kuyenera kusankhidwa chifukwa cha kuchepa kwa kuchuluka kwa amoxicillin kwinaku ndikusintha kwacudiulanic acid.
  Odwala omwe ali ndi vuto la chiwindi
  Odwala omwe ali ndi vuto la chiwindi, mankhwalawa amagwiritsidwa ntchito mosamala, ndikofunikira kuyang'anira ntchito ya chiwindi nthawi zonse.
  Zonsezi zimachotsedwa ndi hemodialysis komanso zochepa pang'onopang'ono diitosis.

  Zizindikiro zogwiritsidwa ntchito

  Matenda oyambitsidwa ndi tizilombo tating'onoting'ono tating'ono:
  • Matenda am'mapapo apakati a kupuma ndi ziwalo za ENT (kuphatikizapo pachimake ndi matenda osachiritsika, mafupa am'mimba komanso otitis, pharyngeal abscess, tonsillitis, pharyngitis),
  • matenda ochepa kupuma thirakiti (kuphatikizapo pachimake bronchitis ndi bakiteriya wamphamvu, chifuwa, chibayo),
  • matenda amkodzo thirakiti,
  • matenda ku matenda azachipazi,
  • matenda a pakhungu ndi minofu yofewa, komanso mabala ochokera pakuluma kwa anthu ndi nyama,
  • matenda a mafupa komanso osakanikirana,
  • matenda am'mimba thirakiti (cholecystitis, cholangitis),
  • odontogenic matenda.

  • Hypersensitivity pamagawo a mankhwala,
  • Hypersensitivity m'mbiri mpaka penicillin, cephalosporins ndi mankhwala ena a beta-lactam,
  • cholestatic jaundice komanso / kapena chiwindi china chodwala chifukwa cha mbiri ya amoxicillin / clavulanic acid,
  • matenda a mononucleosis ndi khansa ya m'mimba,
  • ana osakwana zaka 12 kapena masekeli osakwana 40.

  Ndi chisamaliro

  Pseudomembranous colitis mu anamnesis, matenda am'mimba, chiwindi kulephera, kupweteka kwambiri kwaimpso, kutenga pakati, kuyamwa, pamene mukugwiritsa ntchito anticoagulants.

  Gwiritsani ntchito pa nthawi yoyembekezera komanso nthawi yoyamwitsa

  Kafukufuku wazinyama sanawululire zowopsa za kumwa mankhwalawa panthawi yomwe ali ndi pakati komanso momwe zimakhudzira kukula kwa fetal.
  Kafukufuku m'modzi mwa azimayi omwe ali ndi vuto la zamkati mwachangu anapeza kuti kugwiritsa ntchito prophylactic wa amoxicillin / clavulanic acid kumatha kuphatikizidwa ndi chiopsezo chowonjezeka cha necrotizing enterocolitis mwa akhanda.
  Pa nthawi yoyembekezera komanso mkaka wa m'mawere, mankhwalawa amagwiritsidwa ntchito pokhapokha ngati phindu lomwe limaperekedwa kwa mayi limaposa chiwopsezo cha mwana wosabadwayo ndi mwana.
  Amoxicillin ndi clavulanic acid ochepa omwe amalowa mkaka wa m'mawere.
  Mu makanda omwe amalandila yoyamwitsa, kukula kwa chidwi, kutsegula m'mimba, ma micidi a mucous nembanemba amkamwa amatha. Mukamamwa Amoxiclav®, ndikofunikira kusankha pakuyamwa.

  Mlingo ndi makonzedwe

  Mkati.
  Mlingo wa mankhwalawa umayikidwa payekha kutengera zaka, kulemera kwa thupi, impso ya wodwalayo, komanso kuwuma kwa matenda.
  Amoxiclav ® ikulimbikitsidwa kuti idatenge kumayambiriro kwa chakudya kuti mayamwidwe bwino komanso kuti muchepetse zotsatira zoyipa zamagetsi.
  Njira ya chithandizo ndi masiku 5-14. Kutalika kwa nthawi ya chithandizo akutsimikiza ndi dokotala. Kuchiza sikuyenera kupitirira masiku opitilira 14 popanda kupimidwa kachiwiri.
  Akuluakulu ndi ana a zaka 12 kapena kupitirira kapena masekeli 40 kapena kupitilira:
  Zochizira matenda ofatsa pang'ono - - piritsi 250 250 mg + 125 mg maola 8 aliwonse (katatu pa tsiku).
  Zochizira matenda opweteka kwambiri komanso matenda opumira - 1 piritsi 500 mg + 125 mg maola 8 aliwonse (katatu pa tsiku) kapena piritsi limodzi 875 mg + 125 mg maola 12 aliwonse (kawiri pa tsiku).
  Popeza mapiritsi osakanikirana a amoxicillin ndi clavulanic acid a 250 mg + 125 mg ndi 500 mg + 125 mg ali ndi kuchuluka komweko kwa clavulanic acid - 125 mg, mapiritsi 2 a 250 mg + 125 mg siofanana ndi piritsi limodzi la 500 mg + 125 mg.
  Odwala ndi mkhutu aimpso ntchito
  Kusintha kwa dose kumakhazikitsidwa ndi mlingo woyenera wambiri wa amoxicillin ndipo umakhazikitsidwa ndi clearinine chilolezo (QC).

  QC	Amoxiclav® dosing regimen
  > 30 ml / mphindi	Palibe kusintha kwa mlingo wofunikira
  10-30 ml / mphindi	1 piritsi 500 mg + 125 mg 2 nthawi / tsiku kapena piritsi limodzi 250 mg + 125 mg 2 kawiri / tsiku (kutengera zovuta za matendawa).
  30 ml / mphindi. Odwala omwe ali ndi vuto la chiwindi Amoxiclav ® iyenera kumwedwa mosamala. Kuwunikira pafupipafupi kwa ntchito ya chiwindi ndikofunikira. Sifunikira kukonzanso mlingo wa odwala okalamba. Okalamba odwala mkhutu aimpso ntchito, mankhwalawa ayenera kusintha ngati odwala akuluakulu omwe ali ndi vuto laimpso. Zotsatira zoyipa Malinga ndi World Health Organisation (WHO), zotsatira zosafunikira zimagawidwa malinga ndi kuchuluka kwawo kwa chitukuko motere: Nthawi zambiri (≥1 / 10), nthawi zambiri (≥1 / 100, Akulimbikitsidwa Momwe mungadye cranberries a shuga Pancreatic Magnetic Resonance Imaging Sipinda yotsekemera - ndi chiyani? Kodi ndi ziti zomwe zikuwonetsa kuti khofi wapa shuga umagwirizana ndi chizolowezi? Kusiya Ndemanga Yanu Popular Nkhani Glycated hemoglobin pakuwona matenda a shuga Zizindikiro Kukwezedwa kwa insulin kwamadzi kumatanthauza Insulin Malangizo ogwiritsira ntchito Glidiab MV Chithandizo ndi kupewa Posts Popular Thandizo Kupewa matenda a shuga Thandizo 2018 Kupewa kwa matenda ashuga A shuga ndi matenda a endocrine system, momwe kagayidwe kazakudya, mafuta, mapuloteni komanso kuchuluka kwa madzi kumasokonekera. ... Makoko a shuga Zakudya za shuga Syringe cholembera cha insulin Humulin NPH, M3 ndi Wokhazikika: mitundu ndi malamulo ogwiritsira ntchito Chithandizo ndi kupewa Kodi parsley ndi shuga Zakudya za shuga Gulu Magazi a shuga m'magaziChithandizo ndi kupewaZakudya za shugaChisamaliroKukakamizidwaKuwongolera matenda a shugaMwendo umapweteka, phazi la matenda ashugaMatenda a shugaMafunsoMatenda a shuga Kusankha Mkonzi Kulimbitsa chitetezo chathu cha mthupi: Kodi ndi zakudya ziti za shuga zomwe mungadye komanso ziti? Zakudya za shuga, 2018 Ntchito ya insulin mthupi: timadzi timene timakhala ndi shuga? Insulin, 2018 Zakudya za matenda ashuga zoyambira Zakudya za shuga, 2018 Posts Popular Chithandizo cha mabala amiyendo osachiritsika odwala matenda ashuga Matenda a shuga, 2018 Ubwino wa Kombucha wa odwala matenda ashuga Zakudya za shuga, 2018 Cerebral atherosulinosis yamitsempha yamagazi Matenda a shuga, 2018 pobedidijabetes.org © Copyright 2024. All Rights Reserved. | Matenda Atsoka!