Malangizo ogwiritsira ntchito Glidiab MV

Chithandizo cha matenda ashuga sichingosintha m'zakudya zokha, komanso pakugwiritsa ntchito mankhwala apadera.

Ndi nthenda yachiwiri, anthu amakonda mankhwala kuti akwaniritse glycemia. Njira imodzi yothetsera vutoli ndi Glidiab MV.

Zambiri, kapangidwe ndi mawonekedwe ake amasulidwe

Mankhwala Glidiab MV ndi amodzi mwa zotumphukira za sulfonylurea (2 mibadwo), chifukwa chake adapangidwa kuti alimbikitse maselo a beta omwe amapezeka m'matumbo.

Mankhwalawa amapangidwa m'chigawo cha Moscow ndi kampani ya mankhwala Akrikhin ndipo amadziwika kuti ndi mapiritsi a hypoglycemic Diabeteson MV, opangidwa ku France. Wothandizirayo ali ndi mtundu wa Mlingo wodziwika ndi kumasulidwa kosinthidwa.

Mankhwalawa amapezeka mu mawonekedwe a mapiritsi okhala ndi kuyera kwake. Zili ngati ma cylinders athyathyathya. Mankhwalawa amapezeka m'matumba a 30 kapena 60 mapiritsi.

Poyerekeza ndi Diabeteson MV, yomwe ili ndi mulingo wa 0,06 g, Glidiab MV ili ndi theka logwira ntchito (0.03 g).

• Gliclazide ndiye chinthu chachikulu,
• cellulose (microcrystalline),
• hydroxypropyl methylcellulose,
• magnesium wakuba,
• Aerosil

Odwala ambiri amalembedwa Glidiab 80, yomwe ili ndi yogwira, osati 30 mg, koma 80 mg piritsi lililonse.

Zotsatira za pharmacological

Zigawo za Glidiab MV zimakhudza thupi motere:

• imathandizira kubisalira kwa insulin yopangidwa mu kapamba,
• kuwonjezera kukhudzika kwa minofu kumadzi opangidwa,
• chepetsani nthawi yanu kuchokera pakudya panthawi yomwe chakudya chikufunika,
• Mothandizidwa ndi mankhwalawa, insulin katulutsidwe amabwezeretsedwa kumayambiriro poyerekeza ndi mankhwala ena a sulfonylurea,
• Sinthani kukoka kwa microscircular chifukwa cha kuphatikiza mapulatele, kubwezeretsanso kupezeka kwa khoma la mtima komanso chiopsezo chochepa cha micothrombosis,
• chepetsa glycemia,
• thandizani kuthetsa protenuria,
• chepetsani kukula kwa retinopathy,
• amathandizira kuchepetsa thupi, malinga ndi zakudya zoyenera.

Pharmacokinetics

Njira ya mayamwidwe, kugawa mu thupi, kagayidwe kachakudya ndi kupukusira kwa zinthu zimachitika motere:

1. Zogulitsa. Mankhwalawa ali pafupifupi odziwikiratu kudzera m'matumbo am'mimba (matumbo am'mimba). Kuphatikizika kwake kumawonjezeka m'madzi a m'magazi pang'onopang'ono, mpaka kufika pazomwe zimayambira pambuyo pa maola 6 kapena 12. Zakudya zazing'ono sizimakhudza kuchuluka kwa mayamwidwe. Mankhwalawa ndi othandizira kwa maola 24.
2. Kugawa. Kulumikizana ndi mapuloteni a plasma ndi zigawo zama mankhwala akhazikitsidwa pa 95%.
3. Kupenda. Izi zimachitika m'chiwindi, zomwe zimadziwika ndi mapangidwe ofananira metabolites.
4. Kuswana. Excretion imachitika kudzera mu impso mu mawonekedwe a metabolites, ndi 1% yokha ya mankhwala omwe amatuluka ndi mkodzo. Kutha kwa theka la moyo wa mankhwalawa kumachitika maola 16.

Mapulogalamu a pharmacokinetic a mankhwala mwa odwala okalamba sasintha.

Zizindikiro ndi contraindication

Mapiritsi a Glidiab MV ndi mankhwala a hypoglycemic, chifukwa chake amagwiritsidwa ntchito pochiza matenda amtundu wa 2, pamene njira zina zochepetsera glucose sizinabwezeretse chizindikirocho.

Zotsatira zoyenera kumwa mankhwalawa ndi:

• ketoacidosis
• kuphwanya impso ntchito,
• Mtundu woyamba wa shuga
• chikomokere (diabetes kapena hyperosmolar),
• machitidwe
• kuvulala
• matumbo,
• mimba
• zinthu zoyambitsa hypoglycemia (mwachitsanzo, matenda opatsirana)
• leukopenia
• kuwotcha kwakukulu
• Hypersensitivity zinthu zomwe zili mu mankhwala,
• yoyamwitsa.

Malangizo ogwiritsira ntchito ndi malangizo apadera

Mlingo wa mankhwalawa umatengera mawonekedwe a shuga komanso mawonekedwe ake, chifukwa chake amasankhidwa ndi dokotala aliyense payekha kwa wodwala aliyense.

Kumayambiriro kwa kumwa mankhwalawa, mufunika 30 mg kapena piritsi limodzi. Kutengera momwe wodwalayo alili panthawi ya mankhwala, kuchuluka kwa zinthu zogwira ntchito patsiku kungathe kuwonjezeka mpaka 120 mg (mlingo waukulu).

Mapiritsi amatengedwa pakamwa pa kadzutsa (kamodzi patsiku). Kuchepa kwambiri kwa impso (ndi creatinine kuyambira 15 mpaka 80 ml / mphindi) sikutanthauza kusintha kwa mlingo.

Kumayambiriro kwa mankhwala osokoneza bongo mpaka mlingo woyenera utasankhidwa, odwala omwe ali ndi vuto la hypoglycemia sayenera kugwira ntchito yofunika kuyankha mwachangu kapena chidwi chochulukirapo.

Amayi sayenera kugwiritsa ntchito mankhwalawa panthawi yakubala, komanso kuyamwitsa.

Kuwonongeka kwakukulu kwa impso kapena chiwindi kumaletsa kugwiritsa ntchito mankhwalawo ngakhale pazingwe zochepa.

1. Chofunikira kuti mukwaniritse zotsatira za ntchito ndikutsatira kudya komanso kuchita masewera olimbitsa thupi. Pazakudya za tsiku ndi tsiku, chakudya chopatsa mphamvu chimayenera kupezeka mokwanira.
2. Ndikofunikira kuti glycemia imayang'aniridwa isanachitike komanso itatha chakudya kuti mankhwalawa asinthidwe kutengera zotsatira za muyeso.
3. Pochita opaleshoni kapena matenda a shuga, mankhwalawo amayenera kulowedwa ndi jakisoni wa insulin.
4. Pofuna kupewa kuwonongeka kwa hypoglycemia, komanso kusachita ngati disulfiram, musamwe mowa.
5. Sizoletsedwa kudumphira chakudya, osasamala zokhwasula-khwasula panthawi yachinyamata.
6. Pamaso ntchito zolimbitsa thupi, mlingo uyenera kuchepetsedwa.

Mankhwala omwe amadziwika kwambiri ndi mankhwala a hypoglycemic ndi awa:

• anthu okalamba
• odwala omwe sangathe kudya mokwanira,
• anthu okhala ndi thupi lofooka
• odwala omwe ali ndi matenda monga pituitary-adrenal insufficiency.

Zotsatira zoyipa ndi bongo

Kumwa mapiritsi kumatha kuyambitsa zotsatirazi mwa munthu:

• mokhudzana ndi endocrine system - hypoglycemia yokhala ndi mawonekedwe am'mutu, thukuta, kufooka, kukhumudwa, kugwedezeka, kuzindikira, kusawona bwino komanso kuyendetsa kayendedwe,
• Kuchokera mgawo - dyspepsia, anorexia, kusokonezeka kwa chiwindi,
• leukopenia, thrombocytopenia, kuchepa magazi,
• mawonetseredwe a thupi lawo lonse (kuyabwa, zidzolo, kapena urticaria).

Ndi mankhwala osokoneza bongo ambiri, hypoglycemia imachitika. Kuti muchepetse chizindikiro chake, ndikokwanira kudya chakudya chamagulu angapo, ngati munthuyo akudziwa. Pomwe wodwala sangathenso kudya yekha, amayenera kupatsidwa shuga wambiri (40%) ndi jakisoni wambiri wa glucagon. Pambuyo pobwerera kwa munthu wodwala matenda ashuga, mukufunikirabe kuluma kuti muchepetse kuguluka kwa shuga.

Kuchita ndi mankhwala ena ndi analogi

Kugwiritsa ntchito mankhwala ena molumikizana ndi Glidiab MV kungalimbikitse kapena kuchepetsa mphamvu ya hypoglycemic.

Mankhwala osakanikirana ndi mankhwala monga:

• ACE zoletsa,
• antifungal agents (fluconazole),
• NSAIDs
• antihistamines
• Fibates
• odana ndi chifuwa chachikulu
• Salicylates,
• Pentoxifylline
• Ethanoli
• mankhwala omwe amatchinga katulutsidwe ka tubular.

Mphamvu ya hypoglycemic imaphatikizidwa akaphatikizidwa ndi mankhwala otsatirawa:

• barbiturates
• thiazide okodzeya,
• Furosemide
• mahomoni kuti azisamalira chithokomiro,
• Kukonzekera kwa lifiyamu
• estrogens
• njira zakulera pakamwa.

Mwa mankhwala omwe ali ndi vuto lofanana ndi mapiritsi a Glidiab MV, zotsatirazi nthawi zambiri zimalembedwa:

• Meglimide
• Guwa
• Glibetic,
• Clay,
• Glimepiride
• Eglim
• Kukongola
• Glibenclamide,
• Ziphuphu.

Makanema okhudzana ndi matenda ashuga, chithandizo ndi kupewa:

Lingaliro la odwala ndi madotolo

Kuchokera pakuwunika kwa wodwala, titha kunena kuti mankhwalawa amalekeredwa bwino komanso ogwira ntchito. Komabe, madokotala amalimbikira kugwiritsa ntchito mankhwalawo pokhapokha atakumana ndi katswiri.

Njira zabwino kwambiri. Poganizira za kupsinjika kwakukulu, ndidapeza pafupifupi 30 kg, ngakhale sindinasinthe kwambiri kadyedwe kanga. Zotsatira zake, ndinapeza shuga wambiri wamwazi. Dotolo adandiwuza kuti ndimwe mapiritsi awiri a Glidiab MV m'mawa uliwonse, ndimamwa piritsi limodzi la Glucofage 1000 madzulo .. Chifukwa cha mankhwalawa, index ya glucose idagwa ndi magawo anayi ndipo ikupitirirabe pafupifupi 7 mmol / L mosalekeza.

Kristina, wodwala, wazaka 47

Mankhwala ndi osavuta kugwiritsa ntchito. Glidiab CF ali ndi zotsutsana zambiri, kotero odwala sayenera kuyamwa okha popanda kuvomerezedwa ndi adokotala. Ndikofunikira kuyang'anitsitsa glycemia ndikuwunika magwiridwe antchito a shuga limodzi ndi endocrinologist. Ndi regimen yoyenera yamankhwala, ndizotheka kutulutsa msanga kuchuluka kwa shuga. Mankhwalawa amagawidwa m'masitolo ndi mankhwala, koma nzika zomwe zimadwala matendawa zimalandira kwaulere, malinga ndi kuyang'aniridwa kosalekeza ndi akatswiri a chipatala chawo.

Victor Vladimirovich, dokotala

Mtengo wa mapiritsi 60 a Glidiab MV mu phukusi ndi ma ruble 200.