Momwe mungagwiritsire ntchito mankhwala a Augmentin SR?

Matenda oyambitsidwa ndi bakiteriya omwe amapezeka ndi tizilombo tating'onoting'ono tomwe timayambitsa matenda ochepa: kupuma kwam'mimba thirakiti (bronchitis, chibayo, matenda a m'mimba, zotupa zam'mapapo), matenda amtundu wa ENT (sinusitis, tonsillitis, otitis media), matenda amtundu wa genitourinary ndi ziwalo za pelvic (pyelonephritis, pyelitis, cystitis, urethritis, prostatitis, cervicitis, salpingitis, salpingoophoritis, tubo-ovarian abscess, endometritis, bakiteriya vaginitis, kuchotsa septic, pambuyo pake, sepsis, pelvioperitonitis, chancre yofewa, gonorrhea, matenda a pakhungu ndi minofu yofewa (erysipelas, impetigo, secondary koma dermatoses kachilombo, abscesses, cellulitis, bala matenda), osteomyelitis, matenda postoperative, kupewa matenda opaleshoni.

Mlingo

Filimu yokhala ndi makina otulutsidwa otulutsa mafilimu, lyophilisate pokonzekera yankho la kulowetsedwa kwamkati, ufa pokonzekera kuyimitsidwa kwa makonzedwe am'kamwa, mapiritsi, ufa pakukonzekera njira yothetsera kulowetsedwa kwa mtsempha, mapiritsi

Contraindication

Hypersensitivity a Augmentin CP zigawo zina (kuphatikizapo cephalosporins ndi mankhwala ena a beta-lactam), mononucleosis wophatikiza (kuphatikizapo mawonekedwe a chotupa), phenylketonuria, zigawo za jaundice kapena chiwindi chodwala chifukwa chogwiritsa ntchito amoxicillin / clavulanova mbiri ya acid, CC yochepera 30 ml / min (mapiritsi 875 mg / 125 mg).

Momwe mungagwiritsire ntchito: Mlingo ndi njira ya chithandizo

Mlingo wa Augmentin SR amaperekedwa molingana ndi amoxicillin. Mlingo wa mankhwalawa umakhazikitsidwa payekhapayekha kutengera kuwopsa kwa maphunzirowo ndi malo omwe matendawa alowa, chidwi cha tizilomboti.

Ana ochepera zaka 12 - mawonekedwe ena a LF okonzekera omwe ali ndi zinthu zomwezo: kuyimitsidwa, manyowa kapena madontho olowera pakamwa. Mlingo umodzi umakhazikitsidwa malinga ndi zaka zake: ana mpaka miyezi itatu - 30 mg / kg / tsiku mu magawo awiri ogawanika, miyezi itatu ndi okulirapo - matenda opatsirana modabwitsa - 25 mg / kg / tsiku mu 2 mg waukulu kapena 20 mg / kg / tsiku Mlingo 3, odwala kwambiri - 45 mg / kg / tsiku mu 2 Mlingo kapena 40 mg / kg / tsiku mu 3 waukulu.

Akuluakulu ndi ana opitirira zaka 12 kapena zolemera makilogalamu 40 kapena kupitilira: 500 mg 2 nthawi / tsiku kapena 250 mg katatu kapena tsiku. Odwala kwambiri ndi matenda opatsirana thirakiti - 875 mg 2 nthawi / tsiku kapena 500 mg katatu / tsiku.

Mulingo wambiri tsiku lililonse wa amoxicillin wa akulu ndi ana opitirira zaka 12 ndi 6 ga, kwa ana ochepera zaka 12 - 45 mg / kg thupi.

Mlingo wambiri watsiku ndi tsiku wa clavulanic acid kwa akulu ndi ana opitirira zaka 12 ndi 600 mg, kwa ana ochepera zaka 12 - 10 mg / kg thupi.

Ngati kumeza kuli kovuta mwa akulu, kuyimitsidwa kumalimbikitsidwa.

Ngati matenda a impso alephera, mlingo ndi pafupipafupi waudindo zimayendetsedwa (makonzedwe a LF omwe ali ndi zinthu zomwezi kuchokera kwa opanga ena) malinga ndi QC: ndi QC yoposa 30 ml / min, kusintha kwa mlingo sikofunikira, ndi QC 10-30 ml / min: mkati - 250- 500 mg / tsiku lililonse maola 12, ndi CC zosakwana 10 ml / mphindi - 1 g, ndiye 500 mg / tsiku iv kapena 250-500 mg / tsiku pakamwa kamodzi. Kwa ana, mlingo uyenera kuchepetsedwa chimodzimodzi.

Odwala pa hemodialysis - 250 mg kapena 500 mg ya Augmentin CP pakamwa limodzi, gawo limodzi pa dialysis ndi wina mlingo 1 kumapeto kwa gawo la dialysis.

Zotsatira za pharmacological

Kuphatikiza kophatikizira kwa amoxicillin ndi clavulanic acid, choletsa-lactamase inhibitor. Imagwira bactericidal, imalepheretsa kapangidwe ka khoma la bakiteriya.

Yogwira pakulimbana ndi bakiteriya wa gram - kuphatikizapo beta-lactamase yopanga tizilombo ta: Staphylococcus aureus,

mabakiteriya aerobic gram-negative: Enterobacter spp., Escherichia coli, Haemophilus influenzae, Klebsiella spp., Moraxella catarrhalis.

Tizilombo toyambitsa matenda totsatirazi timagwiritsidwa ntchito ndi Augmentin CP kokha mu vitro: Staphylococcus epidermidis, Streptococcus pyogene, Streptococcus anthracis, Streptococcus pneumoniae, Streptococcus viridans, Enterococcus faecalis, Coryneococcocpoccus peptes.

mabakiteriya osokoneza bongo a aerobic gramu-kuphatikizapo michere ya beta-lactamase): Proteus mirabilis, Proteus vulgaris, Salmonella spp., Shigella spp. ), Campylobacter jejuni,

mabakiteriya a anaerobic gram-osavomerezeka (kuphatikiza mitundu yopanga beta-lactamases): Bacteroides spp. kuphatikiza Bacteroides fragilis.

Clavulanic acid mu Augmentin CP zoletsa mtundu II, III, IV ndi V mitundu ya beta-lactamases, yogwira motsutsana ndi mtundu I beta-lactamases, yopangidwa ndi Pseudomonas aeruginosa, Serratia spp, Acinetobacter spp. Clavulanic acid imakhala yotentha kwambiri chifukwa cha penicillinases, chifukwa imapanga zovuta ndi enzyme, yomwe imalepheretsa kuchepa kwa enzymatic pansi pa mphamvu ya beta-lactamases.

Zotsatira zoyipa

Kuchokera pamiyambo ya m'mimba: kusanza, kusanza, kutsegula m'mimba, gastritis, stomatitis, glossitis, kuchuluka kwa "chiwindi" transaminases, nthawi zina - cholestatic jaundice, hepatitis, kulephera kwa chiwindi (nthawi zambiri okalamba, abambo, omwe ali ndi chithandizo chambiri), pseudomembranous ndi hemorrhagic colitis (itha kupanga pambuyo pa mankhwala), enterocolitis, lilime la "tsitsi" lakuda, kudetsa khungu la mano.

Hematopoietic ziwalo: kuwonjezereka kosinthika kwa prothrombin nthawi ndi nthawi ya magazi, thrombocytopenia, thrombocytosis, eosinophilia, leukopenia, agranulocytosis, hemolytic anemia.

Kuchokera ku dongosolo lamanjenje: chizungulire, kupweteka mutu, chithokomiro, nkhawa, kusintha kwa machitidwe, kupweteka.

Zomwe zimachitika mdera: nthawi zina, phlebitis pamalo a jekeseni wa iv.

Thupi lawo siligwirizana ndi Augmentin SR zigawo zikuluzikulu: urticaria, erythematous totupa, kawirikawiri - multiforme exudative erythema, anaphylactic mantha, angioedema, osowa kwambiri - exfoliative dermatitis, zilonda zapamwamba zotupa za erythema (Stevens-Johnson syndrome), ziwengo vasculitis, serum vasculitis pachimake kwambiri pantulosis

Zina: candidiasis, kukula kwa mphamvu, interstitial nephritis, crystalluria, hematuria.

Malangizo apadera

Ndi chithandizo cha maphunzirowa ndi Augmentin SR, ndikofunikira kuwunika momwe ntchito ya magazi, chiwindi ndi impso.

Pofuna kuchepetsa chiwopsezo cha mavuto obwera kuchokera m'matumbo am'mimba, mankhwalawa amayenera kumwa ndi zakudya.

Ndikotheka kukhala ndi superinitness chifukwa cha kukula kwa microflora sazindikira izi, zomwe zimafunikira kusintha kofananirana ndi mankhwala opha maantibayotiki.

Zitha kupereka zotsatira zabodza pakupanga shuga mu mkodzo. Poterepa, tikulimbikitsidwa kugwiritsa ntchito njira ya glucose oxidant pofufuza kuchuluka kwa shuga mumkodzo.

Pambuyo pa kuchepetsedwa, kuyimitsidwa kuyenera kusungidwa osaposa masiku 7 mufiriji, koma osapanga chisanu.

Odwala omwe ali ndi hypersensitivity ku penicillin, zovuta zomwe zimachitika ndi mankhwala a cephalosporin zimatheka.

Nkhani za kukula kwa necrotizing colitis mu akhanda ndi amayi apakati omwe ali ndi nthawi yopasuka ya zimitseko zinaululidwa.

Kuchita

Maantacid, glucosamine, mankhwala othandizira, aminoglycosides amachepetsa ndikuchepetsa mayamwidwe a Augmentin CP, ascorbic acid imawonjezera kuyamwa.

Mankhwala a Bacteriostatic (macrolides, chloramphenicol, lincosamides, tetracyclines, sulfonamides) amakhala ndi zotsatira zotsutsana.

Zimawonjezera kugwira ntchito kwa anticoagulants osalunjika (kupondereza microflora yamatumbo, kumachepetsa kapangidwe ka vitamini K ndi index ya prothrombin). Ndi munthawi yomweyo makonzedwe a anticoagulants, ndikofunikira kuyang'anira zomwe zikuwonetsa magazi.

Amachepetsa mphamvu ya njira zakulera zam'mlomo, mankhwala, panthawi ya kagayidwe kamene PABA imapangidwa, ethinyl estradiol - chiopsezo cha magazi "kupunduka".

Ma diuretics, allopurinol, phenylbutazone, NSAIDs ndi mankhwala ena omwe amatsekera katulutsidwe ka tubular kumawonjezera kuchuluka kwa amoxicillin pakupanga Augmentin SR (clavulanic acid imachotsedwa makamaka ndi kusefera kwa glomerular).

Allopurinol imawonjezera mwayi wokhala ndi zotupa pakhungu.

Mafunso, mayankho, ndemanga pa mankhwala a Augmentin SR

Zomwe zimaperekedwa zimakonzekera akatswiri azamankhwala komanso zamankhwala. Chidziwitso chokwanira chokhudza mankhwalawa chili m'malangizo omwe amaphatikizidwa ndi zomwe amapanga ndi wopanga. Palibe chidziwitso chomwe chatumizidwa patsamba lino kapena tsamba lililonse la tsamba lathu chomwe chingagwire ntchito ngati cholowa m'malo mwapadera kwa katswiri.

Kutulutsa Fomu

Augmentin amapezeka m'mapiritsi okhala ndi mafilimu, ufa wa jakisoni, komanso chinthu chouma pakubwezerera madontho. Zochulukitsa pokonzekera kuyimitsidwa kwa Augmentin ndi madzi zimapangidwanso. Zotsatira zamankhwala omwe ali ndi zinthu zomwezi omwe amagwira ntchito ndi awa: Amoxiclav, Bactoclav, Arlet, Klamosar.

Mlingo ndi makonzedwe

Malinga ndi malangizo Augmentin tikulimbikitsidwa kuti adye kumayambiriro kwa chakudya, Mlingo wa mankhwalawa umapangidwa malinga ndi msinkhu wa wodwalayo komanso kuopsa kwa matenda. Ndi chithandizo, n`kotheka kuchita gawo la mankhwala - choyamba, intravenous makonzedwe a mankhwalawa amagwiritsidwa ntchito, kenako amasintha pakamwa. Njira ya chithandizo ndi Augmentin nthawi zambiri sikhala masiku 14 osanenanso chithunzi chachipatala. Kwa akulu ndi ana opitilira zaka 12, amamulembera matenda piritsi limodzi la 0.375 g katatu pa tsiku, matenda akulu 1 piritsi 0.625 g kapena mapiritsi awiri 0,375 g katatu patsiku. Mothandizidwa ndi mtsempha wa magazi, amaloledwa kugwiritsa ntchito mankhwalawa tsiku lililonse kwa maola 6 ndi mlingo wokwanira wa 7.2 ga. Odwala omwe ali ndi vuto laimpso pa mankhwalawa amafunika kuwongolera Mlingo wa mankhwala.

Augmentin wa ana osakwana zaka 1 nthawi zambiri amapatsidwa mawonekedwe a madontho. Malangizowo akuwonetsa kuti paazaka zofika miyezi itatu, mlingo umodzi ndi 0,75 ml, kuyambira miyezi itatu mpaka 12 - 1.25 ml. Ngati mankhwalawa ali ndi matenda opatsirana kudzera pakhungu mkati mwa maola 6 aliwonse, mlingo umodzi wa Augmentin wa ana 3 mpaka 3 wazaka ndi 30 mg / kg thupi, mpaka miyezi itatu pa maola 12 aliwonse. Komanso, ana osaposa zaka 12 amatumizidwa kuyimitsidwa kwa Augmentin kapena madzi. Malinga ndi malangizowo, ana kuyambira miyezi isanu ndi inayi mpaka zaka ziwiri amafunsidwa 2.5 ml (0.156 g / 5 ml), kuyambira zaka ziwiri mpaka 7 - 5 ml (0.156 g / 5 ml), kuyambira zaka 7 mpaka 12 - 10 ml (0.156 g / 5 ml) katatu patsiku, ndi matenda oopsa, mlingo umaloledwa kawiri.

Kuyimitsidwa kwa Augmentin kumakonzekera kugwiritsidwa ntchito musanayambe kugwiritsidwa ntchito, ufa umasungunuka m'madzi owiritsa pamoto wa firiji. Madzi amawonjezeredwa chizindikiro cholembedwa pachoteracho, pomwe mkati mwake mumagwedezeka pang'ono, kenako ndikukhazikika mpaka kupasuka kwathunthu pafupifupi mphindi 5. Musanagwiritse ntchito chilichonse, bokosilo liyenera kugwedezedwa mwamphamvu kuti mudziwe kuchuluka kwake, kapu yoyezera imagwiritsidwa ntchito, yopaka madzi mosamala pambuyo ntchito iliyonse. Kuyimitsidwa kothiriridwa kumasungidwa mufiriji kwa masiku osaposa 7, koma sikuzizira.

Mankhwala

Farmakokinetics

Magawo onse a Augmentin® SR (amoxicillin ndi clavulanic acid) ndizosungunuka kwathunthu pamayankho amadzimadzi pazotsatira za pH za thupi. Zonsezi zimapangidwa mwachangu komanso bwino ndi kayendetsedwe kamwa. Kugunda kwa Augmentin® SR imakhala bwino ikamudya itangoyamba kumene chakudya.

Mankhwala

Mlingo(mg)

T> MIC^ h(%)

Cmax (mg/l)

Tmax (h)

Auc

T1 / 2 (h)

Amoxicillin

Augmentin SR 1000 / 62,5 mg x 2

Clavulanate

Augmentin SR 1000 / 62,5 mg x 2

ND - yosatanthauziridwa

T> nthawi ya MIC> osachepera inhibitory ndende

Augmentin Magulu Otulutsidwa Omasulidwa® Ma SRs ali ndi mbiri yapadera ya pharmacokinetic / pharmacodynamic.

Zizindikiro T> MIC yopezeka popereka mankhwala a Augmentin® SR ndiwosiyana kwambiri ndi omwe amapezeka ndi mapiritsi omwewo pakumasulidwa kwa zinthu zofunikira.

Pakaperekedwa pakamwa, zochizira zozama za amoxicillin ndi clavulanic acid zimawonedwa mu minyewa ndi mkati mwa madzi. Zochizira zozama za zinthu zonsezi zimapezeka mu chikhodzodzo, zotupa zam'mimba, khungu, adipose ndi minofu minofu, komanso timadzi tating'onoting'ono tomwe timatupa tambiri, bile ndi mafinya. Amoxicillin ndi clavulanic acid amamangiririka kumapuloteni, kafukufuku wapeza kuti mitengo yomanga mapuloteni ndi 25% ya clavulanic acid ndi 18% ya amoxicillin yawo yonse yama plasma. Mu maphunziro a zinyama, palibe kuwerengera chilichonse mwazinthu zilizonse zomwe zili m'gulu lililonse.

Amoxicillin, monga ma penicillin ena, amatha kupezeka mkaka wa m'mawere. Zotsatira za clavulanic acid zimapezekanso mkaka wa m'mawere. Kafukufuku wothandizira kubereka kwanyama akuwonetsa kuti amoxicillin ndi clavulanic acid amatha kudutsa chotchinga, koma palibe umboni womwe wapezeka wokhudzana ndi chonde chosabereka kapena zoyipa za mwana wosabadwayo.

Amoxicillin amapukusidwa pang'ono mu mkodzo wofanana ndi penicillinic acid wofanana ndi 10-25% ya mankhwalawa. Clavulanic acid imapangidwa m'thupi la munthu mpaka 2,5-dihydro-4- (2-hydroxyethyl) -5-oxo-1H-pyrrole-3-carboxylic acid ndi 1-amino-4-hydroxy-butan-2-amodzi ndipo amachotsedwa ndi mkodzo ndi ndowe, komanso mawonekedwe a kaboni dayokosi wokhala ndi mpweya wotuluka.

Amoxicillin amachotseredwa makamaka ndi impso, pomwe clavulanic acid imachotsedwanso ndi machitidwe a impso ndi owonjezera. Pafupifupi 60-70% ya amoxicillin ndi 40-65% ya clavulanic acid amachotsedwa osasinthika mkodzo. Kuphatikiza pamodzi ndi phenenecid kumalepheretsa kuwonetsa kwa amoxicillin, koma osachedwetsa kuchulukitsidwa kwa impso ndi impso.

Kusintha kwa Mlingo sikofunikira.

Odwala ndi mkhutu aimpso ntchito

Palibe chifukwa chosinthira mlingo wa mankhwalawa ndi mtundu wa creatinine chilolezo> 30 ml / min. Odwala ndi creatinine chilolezo zosakwana 30 ml / min, kumwa mankhwala osavomerezeka.

Odwala a hememalysis

Odwala omwe ali ndi vuto la chiwindi

Gwiritsani ntchito mosamala; zambiri zamalingaliro a dosing sizokwanira.

Mankhwala

Augmentin SR SR combination SR ndi mankhwala ophatikiza omwe ali amoxicillin ndi clavulanic acid, omwe ali ndi mphamvu yambiri ya bactericidal, yogwirizana ndi beta-lactamase.

Amoxicillin ndi mankhwala osokoneza bongo omwe amapanga motsutsana ndi michere yambiri yama gramu ndi gram-negative. Amoxicillin amawonongedwa ndi beta-lactamase ndipo samakhudza tizilombo tating'onoting'ono timene timatulutsa enzyme iyi.

Clavulanic acid ndi beta-lactamate, yofanananso ndi mankhwala opangidwa ndi penicillin, omwe amatha kuphatikiza ma enzymes a beta-lactamase omwe amaletsa penicillin ndi cephalosporins, potero amateteza kutha kwa amoxicillin. Makamaka, imakhala ndi ntchito yayikulu yolimbana ndi plasmid beta-lactamases, yomwe mankhwala osokoneza bongo amakhudzidwa nthawi zambiri, koma osagwira motsutsana ndi mtundu wa 1 chromosomal beta-lactamases.

Kukhalapo kwa clavulanic acid ku Augmentin® SR kumateteza amoxicillin ku zowonongeka za beta-lactamases ndikukulitsa mawonekedwe ake a zochita za antibacterial ndikuphatikizidwa kwa ma cell tizilombo omwe nthawi zambiri amakhala osagwirizana ndi penicillin ena ndi cephalosporins. Clavulanic acid okhala ngati mankhwala amodzi alibe mphamvu zambiri za antibacterial.

Njira yokana kukana

Clavulanic acid imateteza motsutsana ndi kukula kwa kukana komwe kumayambitsa michere ya beta-lactamase. Kapangidwe ka mankhwala pang'onopang'ono ndikamasulidwa kwa zinthu zomwe zimagwira, kumawonjezera mphamvu ya mankhwalawo polimbana ndi tizilombo tating'onoting'ono timene timalimbana ndi penicillin.

Amoxicillin amachititsa kukana kwamtundu wina wa beta-lactam, ma beta-lacamase zoletsa ndi cephalosporins.

Kupita ku Augmentin®SrMa tizilombo totsatirawa ndi omvera:

Zoyipa zamagalamu: Bacillius anthracis, Enterococcus faecalis, Listeria monocytogene, Nocardia asteroids, Streptococcuschibayo *†,

Streptococcus pyogene*†, Streptococcus agalactiae*†, Viridans gulu la streptococcus†, Streptococcus spp. (mitundu ina ya β-hemolytic)*†, Staphylococcus aureus (yokhudza methicillin) *, Staphylococcus saprophyticus (yokhudza methicillin) Coagulase negative staphylococcus (wodwala methicillin)

Ma grram-negative: Bordetella pertussis,Haemophilus influenzae *,

Haemophilus parainfluenzae,Helicobacter pylori,Mwanaxella catarrhalis *,

Neisseria gonorrhoeae,Pasteurella multocida,Vibrio cholera

Borreliaburgdorferi,Leptospiraictterohaemorrhagiae,Treponema pallidum

Zoyipa zaramram: Clostridium spp.,Peptococcus niger,Peptostreptococcus magnus,Peptostreptococcus micros,Peptostreptococcusspp.

Ma gram alibe ana Bacteroides fragilis,Mabakiteriya spp., Kapnocytophaga spp., Eikenellacorrodens,Fusobacteriumnyukiliya,Fusobacterium spp., Porphyromonas spp., Prevotellaspp.

Ma tizilombo tating'onoting'ono tomwe titha kupezeka nawo

Corynebacterium spp., Enterococcus faecium

Zabwinoaerobes:Escherichia coli *, Klebsiella oxytoca, Klebsiella pneumoniae *, Klebsiella spp., Proteus mirabilis, Proteus vulgaris, Proteus spp., Salmonella spp., Shigella spp.

Ma tizilombo okhala ndi chilengedwe:

Acinetobacter spp., Citrobacter freundii, Enterobacter spp., Hafnia alvei,Legionella pneumophila,Morganella morganii,Providencia spp., Pseudomonas spp., Serratia spp., Stenotrophomas maltophilia,Yersinia enterolitica

Chlamydia chibayo, Chlamydia psittaci, Chlamydia spp., Coxiella burnetti, Mycoplasma spp.

* Kuchita bwino kwawonetsedwa m'mayesero azachipatala.

Micro Ma tizilombo tating'onoting'ono ta beta-lactamase

Mlingo ndi makonzedwe

Augmentin® SR iyenera kugwiritsidwa ntchito molingana ndi malangizo apagulu omwe amagwiritsidwa ntchito pakugwiritsa ntchito mankhwala othandizira, komanso chidziwitso chakudziko chokhudzana ndi mankhwalawa.

Augmentin® SR yapangidwa kuti ichiritse kwakanthawi kochepa matenda oyambitsidwa ndi bakiteriya omwe amayambitsidwa ndi tizilombo tating'ono tomwe timayamwa mankhwala.

Kutengeka pang'onopang'ono kwa Augmentin® SR kumasiyana malinga ndi dera ndi nthawi. Ndikofunikira kuti muphunzire zambiri zam'deralo pokhudzana ndi mankhwalawa, komanso, ngati zingatheke, kuti mutenge zomwe mukuwererazo ndikuwunikira.

Pofuna kuwonjezera mayamwidwe a Augmentin® SR ikulimbikitsidwa kumayambiriro kwa chakudya. Kuchiza sikuyenera kupitilizidwa kwa masiku opitilira 14 popanda kuonanso momwe wodwalayo alili.

Mapiritsi a Augmentin® SR ali ndi poyambira yogawa, yolola kuti idulidwe pakati kuti isamwetse, koma osachepetsa mlingo: mbali zonse ziwiri zimayenera kutengedwa nthawi imodzi.

Mlingo woyenera ndi mapiritsi awiri kawiri pa tsiku.

Akuluakulu ndi achinyamata (wazaka 16 ndi kupitirira))

Mapiritsi awiri kawiri pa tsiku kwa masiku 7 mpaka 10

Kuchulukitsa kwa matenda osakhazikika

2 mapiritsi kawiri pa tsiku kwa masiku 7

Pachimake bakiteriya sinusitis

Mapiritsi 2 kawiri pa tsiku kwa masiku 10

Kupewa matenda opatsirana am'deralo opangira mano

Mapiritsi 2 kawiri pa tsiku kwa masiku 5, kuyamba kumwa ayenera kukhala mkati mwa maola atatu atachitidwa opaleshoni

Fomu ya Mlingo siinapangidwire ana osakwana zaka 16.

Chepetsani Augmentin Mlingo® SR siyofunika, Mlingo ndi ofanana ndi akulu.

Odwala ndi mkhutu aimpso ntchito

Palibe chifukwa chosinthira mlingo wa mankhwalawa ndi mtundu wa creatinine chilolezo> 30 ml / min. Odwala ndi creatinine chilolezo zosakwana 30 ml / min, kumwa mankhwala osavomerezeka.

Odwala a hememalysis

Odwala omwe ali ndi vuto la chiwindi

Kugwiritsa ntchito mosamala, ndikofunikira kuyang'anira kuwonekera kwa hepatic nthawi zonse. Palibe deta yokwanira kuvomereza dosing.

Bongo

Zizindikiro m'mimba kukhumudwa ndi kusokonezeka koyenera m'madzi-electrolyte ndizotheka. Amoxicillin crystalluria akufotokozedwa, nthawi zina kumabweretsa kukula kwa aimpso.

Chithandizo: symptomatic mankhwala, kukonza madzi osankhidwa a electrolyte. Augmentin® SR imachotsedwa m'magazi kudzera mu hemodialysis.

Wogwirizira Sitifiketi Yoyang'anira

Laboratoire GlaxoSmithKline, France

(100, njira de Versailles, 78163 Marly-Le-Roi, Cedex)

Adilesi ya bungweli yomwe imavomereza zodula kuchokera kwa ogula pamsika wazogulitsa (katundu) ku Republic of Kazakhstan

GlaxoSmith Klein Export Ltd Office Representative ku Kazakhstan 050059, Almaty, st. Furmanova, 273

Nambala yafoni: +7 727 258 28 92, +7 727 259 09 96

Zithunzi za 3D

Mankhwala

Amoxicillin ndi mankhwala osokoneza bongo owoneka bwino omwe ali ndi ntchito yolimbana ndi ma gram ambiri komanso gram alibe tizilombo. Nthawi yomweyo, amoxicillin amatha kuwonongedwa ndi beta-lactamases, chifukwa chake ntchito yokhala ndi amoxicillin sinafikira tizilombo tomwe timatulutsa timadzi tambiri.

Clavulanic acid, beta-lactamase inhibitor yokhudzana ndi penicillin, amatha kuyambitsa mitundu yambiri ya beta-lactamases yomwe imapezeka mu penicillin ndi cephalosporin zosagwira tizilombo. Clavulanic acid imagwira mokwanira motsutsana ndi plasmid beta-lactamases, yomwe nthawi zambiri imayambitsa kukana kwa bakiteriya, ndipo imagwira ntchito kwambiri motsutsana ndi chromosomal beta-lactamases a mtundu woyamba, omwe saletsedwa ndi clavulanic acid.

Kupezeka kwa clavulanic acid mu Augmentin ® kukonzekera kumateteza amoxicillin kuti asawonongedwe ndi ma enzyme - beta-lactamases, omwe amalola kukulitsa mawonekedwe a antibacterial a amoxicillin.

Kutulutsa pang'onopang'ono kwa amoxicillin mu Augmentin ® SR kukonzekera kumalola kukhalabe ndi chidwi cha zovutazi S. chibayoMomwe mphamvu ya amoxicillin imayambitsidwa ndi mapuloteni omwe amaletsa penicillin S. chibayo, kapena PRSP).

Otsatirawa ndi ntchito yophatikiza ya amoxicillin ndi clavulanic acid mu vitro.

Bacteria imakonda kuphatikizidwa ndi amoxicillin ndi clavulanic acid

Zoyipa zamagalamu: Bacillus anthracis, Enterococcus faecalis, Listeria monocytogene, Nocardia asteroides, Streptococcus pneumoniae 1,2, Streptococcus pyogene 1,2, Streptococcus agalactiae 1,2, gulu la streptococcus Viridans 2, Streptococcus spp. (beta hemolytic streptococci) 1,2, Staphylococcus aureus (yokhudza methicillin) 1, Staphylococcus saprophyticus (tcheru ndi methicillin), coagulase-negative staphylococci (woganizira methicillin).

Ma grram-negative: Bordetella pertussis, Haemophilus influenzae 1, Helicobacter pylori, Moraxella catarrhalis 1, Neisseria gonorrhoeae, Pasteurella multocida, Vibrio cholerae.

Zina: Borrelia burgdorferi, Leptospira icterohaemorrhagiae, Treponema pallidum.

Zoyipa zaramram: Clostr> kuphatikiza Peptococcus niger, Peptostreptococcus magnus, Peptostreptococcus micros.

Ma gram alibe ana Bactero> kuphatikiza Bactero> kuphatikiza Fusobacterium nucleatum, Porphyromonas spp., Prevotella spp.

Bacteria yomwe idayamba kukana kuphatikiza amoxicillin ndi clavulanic acid ndiyotheka

Ma grram-negative: Escherichia coli 1, Klebsiella spp., kuphatikiza Klebsiella oxetoca, Klebsiella pneumoniae 1, Proteus spp., kuphatikiza Proteus mirabilis, Proteus vulgaris, Salmonella spp., Shigella spp.

Zoyipa zamagalamu: Corynebacterium spp., Enterococcus faecium.

Bacteria yomwe imagwirizana mwachilengedwe pakuphatikizidwa kwa amoxicillin ndi clavulanic acid

Ma grram-negative: Acinetobacter spp., Citrobacter freundii, Enterobacter spp., Hafnia alvei, Legionella pneumophila, Morganella morganii, Providencia spp., Pseudomonas spp., Serratia spp., Stenotrophomonas maltophilia, Yersinia enterocolitica.

Zina: Chlamydia spp., kuphatikiza Chlamydia pneumoniae, Chlamydia psittaci, Coxiella burnetii, Mycoplasma spp.

1 Mwa mitundu iyi ya tizilombo tating'onoting'ono, kufunikira kwa zamankhwala kosakanikirana kwa amoxicillin ndi clavulanic acid kwawonetsedwa mu maphunziro azachipatala.

2 Zovuta zamtunduwu za mabakiteriya sizitulutsa ma beta-lactamases. Kuzindikira ndi amoxicillin monotherapy kumasonyezanso chidwi chofanana ndi kuphatikiza kwa amoxicillin ndi clavulanic acid.

Kukana kwamtanda. Amoxicillin akuwonetsa mwachindunji kukana kwamtundu wina wa mankhwala a beta-lactam, komanso kuphatikiza kwa ma beta-lactam odana ndi beta-lactamase zoletsa ndi cephalosporins.

Njira zopewera. Clavulanic acid imateteza amoxicillin ku zowononga za beta-lactamases. Kutulutsa pang'ono pang'onopang'ono kwa mankhwala a Augmentin ® SR kumawonjezera mphamvu ya amoxicillin motsutsana ndi tizilombo tating'onoting'ono tomwe kukana kwake kumachitika chifukwa cha kusintha kwa mapuloteni omanga a penicillin.

Pharmacokinetics

Zosakaniza zonse ziwiri za Augmentin ® SR, amoxicillin ndi clavulanic acid, zimasungunuka bwino m'mayankho amadzimadzi ndi pH ya thupi, ndipo imatengedwa mwachangu komanso mokwanira kuchokera m'matumbo am'mimba atatha kukonzekera pakamwa. Mafuta a yogwira zinthu ndi mulingo woyenera kumwa mankhwala kumayambiriro kwa chakudya.

Pansipa pali paracokinetic magawo a amoxicillin ndi clavulanic acid mutatenga mapiritsi awiri. Augmentin ® SR ndi odzipereka athanzi kumayambiriro kwa chakudya.

Avereji magawo a pharmacokinetic

Clavulanic acid