Humulin® NPH (kuyimitsidwa kwa kayendedwe ka subcutaneous, 10 ml) Soluble insulin (umisiri wa chibadwa cha anthu)

Mlingo ndi makonzedwe

S / c phewa, ntchafu, matako kapena pamimba. Kuwongolera kwa mnofu kumaloledwa.

Mlingo wa Humulin ® NPH umatsimikiziridwa ndi dokotala aliyense payekha, kutengera kuchuluka kwa shuga m'magazi. Mu / kumayambiriro kwa mankhwala a Humulin ® NPH amatsutsana.

Kutentha kwa mankhwala omwe amaperekedwa kuyenera kukhala kutentha kwambiri. Masamba a jakisoni ayenera kusinthidwa kuti malo omwewo sawagwiritsanso ntchito mwina kamodzi pamwezi. Ndi s / c makonzedwe a insulini, chisamaliro chimayenera kutengedwa kuti musalowe mumtsempha wamagazi. Pambuyo pa jakisoni, tsamba la jakisidwe siliyenera kutenthedwa.

Odwala ayenera kuphunzitsidwa bwino kugwiritsa ntchito insulin yobereka. Ndondomeko ya insulin makonzedwe ali payekha.

Kukonzekera mawu oyamba

Pokonzekera Humulin ® NPH mu mbale. Zisanayambe kugwiritsidwa ntchito, Mbale za Humulin ® NPH ziyenera kugudubudwa kangapo pakati pamafinya m'manja mpaka insuliniyo itayambanso kupangika mpaka itakhala yunifolomu, madzi amkaka kapena mkaka. Gwedezani mwamphamvu, monga izi zimatha kuyambitsa foam, zomwe zingasokoneze mlingo woyenera. Osagwiritsa ntchito insulini ngati ili ndi flakes mutasakaniza kapena tinthu tating'ono tomwe timatirira pansi kapena makhoma a vial, ndikupanga mawonekedwe a frosty. Gwiritsani ntchito syringe ya insulin yomwe ikufanana ndi kuchuluka kwa insulin.

Pokonzekera Humulin ® NPH m'makalata. Musanagwiritse ntchito, makatiriji a Humulin ® NPH ayenera kugulitsidwa pakati pa manja nthawi 10 ndikugwedezeka, kutembenukira kwa 180 ° komanso maulendo 10 mpaka insulini itatsitsimuka kwathunthu mpaka itakhala yunifolomu yamadzi kapena mkaka. Gwedezani mwamphamvu, monga izi zimatha kuyambitsa foam, zomwe zingasokoneze mlingo woyenera. Mkati mwa bokosi lirilonse pali galasi yaying'ono yagalasi yomwe imathandizira kusakanikirana kwa insulin. Musagwiritse ntchito insulini ngati ili ndi mapokoso mukasakaniza. Chipangizo cha ma cartridge sichimalola kusakanikirana ndi zomwe zili ndi insulini zina mwachindunji mu cartridge lokha. Makatoniwo sanapangidwe kuti adzazitsidwe. Pamaso pa jekeseni, ndikofunikira kudziwa bwino zomwe wopanga amagwiritsa ntchito cholembera kuti apereke insulin.

Kwa Humulin ® NPH mu cholembera cha SyPinge cha QuickPen ™. Pamaso jakisoni, muyenera kuwerenga Malangizo a QuickPen ™ Syringe pen Instruction.

QuickPen ™ Syringe chole Guide

QuickPen ™ Syringe chole ndi yosavuta kugwiritsa ntchito. Ndi chida chothandizira kuperekera insulin (cholembera cha insulin) cholembera 3 ml (300 PIECES) pakukonzekera kwa insulin ndi zochitika za 100 IU / ml. Mutha kulowa kuchokera ku 1 mpaka 60 ya insulin pa jakisoni. Mutha kukhazikitsa mlingo molondola ndi umodzi. Ngati mayunitsi ambiri akhazikitsidwa, mlingowo ungakonzedwe popanda kutaya insulin. QuickPen ™ Syringe chole ikulimbikitsidwa kuti izigwiritsidwa ntchito ndi singano zopangira Becton, Dickinson ndi Company (BD) zolembera ma syringe. Musanagwiritse ntchito cholembera, onetsetsani kuti singanoyo imalumikizidwa kwathunthu ndi cholembera.

M'tsogolo, malamulo otsatirawa akuyenera kutsatiridwa.

1. Tsatirani malamulo a asepsis ndi antiseptics omwe adokotala amuuzani.

3. Sankhani malo pobayira.

4. Pukuta khungu pamalo opaka jekeseni.

5. Masamba obayira enanso kuti malo omwewo sawagwiritsanso ntchito kamodzi pamwezi.

Kukonzekera ndi Kuyambitsa QuickPen ™ Syringe cholembera

1. Kokani chipewa cha cholembera kuti muchotse. Osazungulira kapu. Osachotsa cholembera ku cholembera. Onetsetsani kuti insulin imayang'ana mtundu wa insulin, tsiku lotha ntchito, mawonekedwe. Pindani pang'onopang'ono cholembera maulendo 10 pakati pa kanjedza ndikutembenuza cholembera ka 10.

2. Tengani singano yatsopano. Chotsani chomata papepala lakunja kwa singano. Gwiritsani ntchito swab ya mowa kupukuta disc ya mphira kumapeto kwa cholembera. Gomerani singano yomwe ili mu chipewa, makamaka, ku cholembera. Skani pa singano kufikira mutalumikizidwa kwathunthu.

3. Chotsani kapu yakunja kuchokera singano. Osataya. Chotsani thumba lamkati la singano ndikuitaya.

4. Chongani cholembera cha QuickPen ™ Syringe cholembera. Nthawi iliyonse muyenera kuwunika insulin. Chitsimikizo cha kutulutsidwa kwa insulini kuchokera ku cholembera kuti chichitike jekeseni iliyonse isanafike pang'onopang'ono mpaka inshuwaransi ikawonekere kuonetsetsa kuti cholembera chakonzeka.

Ngati simukuyang'ana insulin, musanayambe kudwala, mutha kupeza insulin yochepa kwambiri kapena yambiri.

5. Konzani khungu pakukoka kapena kulisonkhanitsa mu khola lalikulu. Ikani singano ya sc pogwiritsa ntchito jekeseni yemwe dokotala wanu wakupatsani. Ikani chala chanu pa batani la mlingo ndikusindikiza mwamphamvu mpaka chitayima kwathunthu. Kuti mulowetse mlingo wathunthu, gwiritsani batani la mlingo ndikuwerengerani pang'onopang'ono mpaka 5.

6. Chotsani singano ndikufinya pang'onopang'ono malo a jakisoni ndi swab ya thonje kwa masekondi angapo. Osatupa malo a jakisoni. Ngati insulin ikung'ambika kuchokera singano, nthawi zambiri wodwalayo sanagwiritse singano pansi pakhungu kwanthawi yayitali. Kukhalapo kwa dontho la insulin pamsana pa singano ndikwabwinobwino, sikukhudza mlingo.

7. Pogwiritsa ntchito singano, inaninso singano ndikuitaya.

Ngakhale manambala amasindikizidwa muwindo la chizindikiro ngati manambala, manambala osamvetseka ngati mizere yolunjika pakati pa manambala.

Ngati mlingo wofunikira pakumuyendetsa uposa kuchuluka kwa zigawo zomwe zatsalira mu cartridge, mutha kuyika kuchuluka kwa insulini mu cholembera ichi ndipo mugwiritse ntchito cholembera chatsopano kuti mumalize muyeso wofunikira, kapena lembani mlingo wonse pogwiritsa ntchito cholembera chatsopano.

Osayesa kubaya insulin potembenuza batani la mlingo. Wodwala sadzalandira insulin ngati atembenuza batani la mlingo. Muyenera kuwonekera pa batani la mlingo molunjika kuti mulandire insulin.

Musayese kusintha mlingo wa insulin panthawi ya jakisoni.

Zindikirani Cholembera sichingalole kuti wodwalayo akhazikitse muyeso wa insulin mopitirira muyeso wa zigawo zomwe zatsala mu cholembera. Ngati mulibe chitsimikizo kuti mlingo wathunthu waperekedwa, simuyenera kulowa wina. Muyenera kuwerengera ndikutsatira malangizo omwe akupezeka mu malangizo ogwiritsira ntchito mankhwalawa. Ndikofunikira kuyang'ana cholembera pa cholembera asanalowe aliyense jakisoni, kuonetsetsa kuti tsiku lotha ntchito latha ndipo wodwalayo akugwiritsa ntchito mtundu woyenera wa insulin, osachotsa chizindikiro pa cholembera.

Mtundu wa batani la syringe cholembera wa QuickPick ™ ulingana ndi mtundu wa Mzere pa cholembera cholembera ndipo zimatengera mtundu wa insulin. Mu buku ili, batani la mlingo limayimitsidwa. Mtundu wa beige wa cholembera cha syringe wa QuickPen ™ umawonetsera kuti umapangidwa kuti ugwiritse ntchito ndi zinthu za Humulin ®.

Kusunga ndi kutaya

Cholembera sichitha kugwiritsidwa ntchito ngati chakhala kunja kwa firiji kwa nthawi yochulukirapo kuposa yomwe idafotokozedwa m'mayendedwe ogwiritsa ntchito.

Osasunga cholembera ndi singano yake. Ngati singanoyo yatsala kuti ikanikizidwe, insulansi ingatuluke m'timalo, kapena insulin ikhoza kupukuta mkati mwa singano, potseka singano, kapena thovu la mpweya litha kupanga katiriji.

Ma cholembera a syringe omwe sagwiritsidwa ntchito ayenera kusungidwa mufiriji kutentha kwa 2 mpaka 8 ° C. Osagwiritsa ntchito cholembera kuti chitauma.

Chingwe chomwe chagwiritsidwa ntchito pakadali pano chizisungidwa pamalo otentha kwambiri pamalo otetezedwa ndi kutentha ndi kuwala, komwe ana sangathe.

Taya singano zogwiritsidwa ntchito polemba-maumboni, zopangira zofananira (mwachitsanzo, zotengera zama biohazardous zvinhu kapena zinyalala), kapena monga momwe katswiri wanu wazachipatala adakulimbikitsira.

Ndikofunikira kuchotsa singano pambuyo pa jekeseni iliyonse.

Tayani chimbudzi chogwiritsa ntchito sindingagwiritse ntchito ndi singano malinga ndi malangizo a dotolo wothandizila malinga ndi zofunikila zotaya zinyalala zakuchipatala.

Osabwezanso zotengera zazitali.

Kutulutsa Fomu

Kuyimitsidwa kwa kayendetsedwe ka subcutaneous, 100 IU / ml. 10 ml ya mankhwalawa osalowa mugalasi Mbale. 1 fl. kuyikidwa mu paketi ya kadikhadi.

3 ml osalowetsedwa magalasi makatoni. Makatoni 5 amaikidwa pachimake. 1 bl. zimayikidwa pabokosi lamakatoni kapena makatoni amaikidwa mu cholembera cha syringe ya QuickPen ™. Ma cholembera asanu a syringe amaikidwa pakatoni.

Wopanga

Yopangidwa ndi: Eli Lilly ndi Company, USA. Lilly Corporate Center, Indianapolis, Indiana 46285, USA.

Atanyamula: ZAO "ORTAT", 157092, Russia, dera la Kostroma, chigawo cha Susaninsky, s. Kumpoto, microdistrict. Kharitonovo.

Cartridges, QuickPen ™ Syringe Pens , yopangidwa ndi Lilly France, France. Zone Industrialiel, 2 ru Colonel Lilly, 67640 Fegersheim, France.

Atanyamula: ZAO "ORTAT", 157092, Russia, dera la Kostroma, chigawo cha Susaninsky, s. Kumpoto, microdistrict. Kharitonovo.

Lilly Pharma LLC ndiye mlendo yekha wa Humulin ® NPH ku Russian Federation.

Mlingo

Kuyimitsidwa kwa subcutaneous makonzedwe a 100 IU / ml

1 ml ya kuyimitsidwa kuli

ntchito yogwira - insulin ya anthu (DNA recombinant) 100 IU,

obwera: sodium hydrogen phosphate, glycerin (glycerol), phenol fluid, methacresol, protamine sulfate, zinc oxide, hydrochloric acid 10% kusintha pH, sodium hydroxide 10% yothetsera kusintha pH, madzi a jakisoni.

Kuyimitsidwa koyera, komwe, kuyimilira, kumakhala exxpatant yowoneka bwino, yopanda utoto kapena mawonekedwe oyera. Mtengo umasinthidwa mosavuta ndikugwedezeka modekha.

Mankhwala

Pharmacokinetics

Humulin® NPH ndiakonzekereratu.

Mbiri yamtundu wa insulini (kuphatikiza kwa glucose kupindika) pambuyo pa jekeseni wa subcutaneous akuwonetsedwa mu chithunzi pansipa ngati mzere wakuda. Kusintha komwe wodwala angakumane nako pa nthawiyo komanso / kapena kuchuluka kwa ntchito ya insulini m'chiwonetsero kumawonetsedwa ngati dera louma. Kusiyana kwamwini pantchito ndi kutalika kwa insulin kumadalira zinthu monga mlingo, kusankha jakisoni, magazi, kutentha, zochitika zolimbitsa thupi.

Zochita za insulin

Nthawi (maola)

Mankhwala

Humulin N NPH ndi insulin yomwe imadziwikiranso.

Chochita chachikulu cha Humulin® NPH ndikukhazikitsidwa kwa kagayidwe ka glucose. Kuphatikiza apo, imakhala ndi anabolic komanso anti-catabolic zotsatira zosiyanasiyana zamthupi. Mu minofu ya minofu, pali kuchuluka kwa glycogen, mafuta acid, glycerol, kuchuluka kwa mapuloteni komanso kuwonjezereka kwa kumwa ma amino acid, koma nthawi yomweyo kumachepa mu glycogenolysis, gluconeogeneis, ketogeneis, lipolysis, proteinabolism ndi kutulutsidwa kwa ma amino acid.

Zotsatira zoyipa

hypoglycemia ndizotsatira zoyipa zomwe zimachitika ndi makonzedwe a insulin, kuphatikiza Humulin® NPH.

Zizindikiro wofatsa kwa zolimbitsa hypoglycemia. , kusunthasuntha, thukuta, njala.

Zizindikiro kwambiri hypoglycemia: kukhumudwa, kusazindikira, kukhudzika. Mwapadera, hypoglycemia ikhoza kufa.

thupi lawo siligwirizana (pafupipafupi kuyambira pa 1/100 mpaka 1/10) ngati redness, kutupa, kapena kuyabwa pamalo opangira jakisoni nthawi zambiri amasiya pakadutsa masiku angapo mpaka milungu ingapo. Nthawi zina, izi zimachitika chifukwa cha zifukwa zosakhudzana ndi insulin, mwachitsanzo, mkwiyo pakhungu ndi wothandizira kuyeretsa kapena jakisoni wosayenera.

zokhudza zonse thupi lawo siligwirizana (pafupipafupi

Mlingo ndi makonzedwe

Mlingo wa mankhwalawa ndi mtundu wa makonzedwe amatsimikiziridwa ndi dokotala aliyense payekhaponse pa wodwala aliyense, poganizira kuchuluka kwa shuga m'magazi.

Kuyimitsidwa kwa kutentha kwa chipinda kumayendetsedwa sc kapena intramuscularly (kuloledwa), mtsempha wa mtsempha wa magazi amatsutsana.

Jakisoni wotsekemera amapangidwa m'mimba, matako, ntchafu kapena mapewa, osaloleza insulin kulowa m'mitsempha yamagazi. Tsamba limodzimodzi la jakisili sayenera kugwiritsidwa ntchito nthawi yopitilira 1 pamwezi (pafupifupi). Pambuyo pa mankhwala, mankhwalawa sangabowoleke.

Asanayambe chithandizo, wodwalayo ayenera kuphunzitsidwa ntchito moyenera momwe angagwiritsidwire ntchito insulin.

Kukonzekera kwa mankhwala

Musanagwiritse ntchito, vial ndi mankhwalawa imaguduzidwa kangapo pakati pa manja, ndikugudungika kakhumi pakati pama manja ndikugwedezeka, maulendo 10 idatembenuka ndi 180 ° mpaka insulini itatsitsimuka kwathunthu ndikusintha ngati madzi osungunuka. Vial / cartridge silingagwedezeke mwamphamvu, chifukwa izi zimatha kupangitsa kupangika kwa thovu, lomwe pambuyo pake lingasokoneze mlingo woyenera.

Insulin, momwe ma flakes amawonedwa mutagwedezeka, kapena pakhoma / pansi pa vial momwe ma cell oyera olimba amapangidwira, ndikupanga zotsatira za mawonekedwe owundana, osagwiritsidwa ntchito.

Kupereka mankhwala kuchokera ku vial, gwiritsani ntchito syringe yolingana ndi kuchuluka kwa insulini yoyendetsedwa.

Makatiriji ogwiritsira ntchito sawalola kuti asakanikize mankhwalawo ndi ma insulini ena. Makatoniwo sanapangidwe kuti adzazitsidwe.

Syringe ya Quick Pen (jakisoni) imakupatsani mwayi kulowetsa zigawo 1-60 za insulin pa jakisoni aliyense. Mlingowo ukhoza kukhazikitsidwa ndikulondola kwa gawo limodzi, ngati mankhwalawa asankhidwa molakwika, akhoza kuwongolera popanda kutaya mankhwalawo.

Jakisoni ayenera kugwiritsidwa ntchito ndi wodwala m'modzi yekha, kufalitsa kwake kwa ena kumathandizira ngati matenda opatsirana. Singano yatsopano imagwiritsidwa ntchito jekeseni iliyonse.

Jakisoni sagwiritsidwa ntchito ngati gawo lina lake lawonongeka kapena laphwanyika. Wodwalayo nthawi zonse azikhala ndi cholembera pang'onopang'ono chifukwa cha kutayika kapena kuwonongeka kwa amene akugwiritsidwa ntchito.

Odwala omwe ali ndi vuto losawona bwino kapena kuwonongeka kwathunthu kwa mawonekedwe ayenera kugwiritsa ntchito jakisoni motsogozedwa ndi anthu owona bwino omwe amadziwa momwe angagwiritsire ntchito.

Pamaso pa jekeseni aliyense, yang'anani cholembera pa cholembera, chomwe chili ndi nthawi yanthawi yomwe chatha ndi mtundu wa insulin. Jakisoni ali ndi batani la imvi, mtundu wake umafanana ndi mzere ndi mtundu wa insulin yomwe imagwiritsidwa ntchito.

Kupereka mankhwala

Singano amagwiritsidwa ntchito kubaya insulin kudzera mwa jakisoni.Musanagwiritse ntchito, ndikofunikira kuwonetsetsa kuti singanoyo imalumikizidwa kwathunthu ndi jekeseni.

Popereka mankhwala a insulin yoposa 60 mayunitsi, jakisoni awiri amachitidwa.

Muzochitika zomwe wodwala alibe kutsimikiza kuti watsala ndi mankhwalawa angati mu cartridge, amatembenuza cholembera ndi nsonga ya singano pansi ndikuyang'ana muyeso pa cholembera wowonekera wa cartridge, chomwe chikuwonetsa kuchuluka kwa insulini yotsalira. Manambalawa sagwiritsidwa ntchito kukhazikitsa mlingo.

Wodwala ngati sangathe kuchotsa kapu kuchokera mu singano, amafunika kuzungulira mosamala nthawi zonse (ndikuwerenga), kenako ndikukoka.

Nthawi iliyonse musanalowe jakisoni, yang'anani cholembera. Kuti muchite izi, chotsani singano yakunja ya singano (siyiponyedwa), ndiye kuti cholowa chamkati (chimaponyedwera kutali), chitembenuzani batani la mlingo mpaka mayunitsi awiri atayikidwa, kuloza jekeseni ndikugunda pa cholembera kuti akatole thovu lakuthwa kumtunda. Kugwira cholembera ndi singano mmwamba, kanikizani batani la mlingo mpaka litayima ndipo nambala 0 ikuwonekera pazenera. Kupitiliza kugwirizira batani la mlingo m'malo obwezeretsedwanso, pang'onopang'ono mulembe mpaka 5. Ngati pali pang'onopang'ono wa insulin pamphumi ya singano, kuyesedwa kumayesedwa ndikuchita bwino. Milandu yomwe insulin ikafika kumapeto kwa singano, sitimayo imayendera kangapo.

Malangizo operekera mankhwala pogwiritsa ntchito jakisoni:

• cholembera chimasulidwa ku chipewa,
• kuyang'ana insulin
• tenga singano yatsopano, chotsani chomata pachikopa chake,
• Chotupa chakumapeto kwa cholembera chimapukutidwa ndi swab choviikidwa mu mowa,
• singano idakulungidwa molunjika m'mbali mwa jakisoni mpaka itakhala yolumikizidwa kwathunthu,
• kuyang'ana kudya kwa insulin,
• kugwiritsa ntchito batani la mlingo kukhazikitsira kuchuluka kwa mankhwalawo,
• singano imayikiridwa pansi pa khungu, ndi chala cholimba ndikulimba batani la mlingo mpaka litasiya kwathunthu. Ngati kuli kofunikira kukhazikitsa mlingo wathunthu - batani limapitilizidwa kugwiritsika ndikuwerengera mpaka 5,
• singano imachotsedwa pansi pakhungu, chigono chakunja chimayikidwa, chimasulidwa kwa jekeseni ndikuyitaya mogwirizana ndi malangizo a dokotala.
• ikani chipewa pa syringe cholembera.

Majekeseni sayenera kusungidwa ndi singano zophatikizika kwa iwo.

Ngati wodwala sazindikira kuti wapereka mlingo wonse, samupatsanso jakisoni wina.

Malangizo apadera

Kuyang'anira kuchipatala kokha ndikofunikira pakusintha mtundu kapena wopanga insulini. Kufunika kosinthira kwa mankhwalawa kumatha kuchitika posintha mtundu, mtundu, ntchito, mitundu ndi (kapena) njira yopanga insulin.

Kusintha kwa mankhwalawa kungafunike poika odwala ena kuchokera ku insulin ya nyama kupita ku insulin ya anthu - onse panthawi yoyambira, ndipo pang'onopang'ono kwa milungu ingapo kapena miyezi ingapo atayamba kugwiritsa ntchito. Tiyenera kukumbukira kuti mwa odwala ena, zizindikiro za kutsogola kwa hypoglycemia pogwiritsa ntchito insulin yaumunthu zitha kutchulidwa pang'ono kapena zosiyana ndi zomwe zimayambika poyambitsa insulin yoyambira nyama.

Ena kapena ena onse mwaotsogola kwa hypoglycemia amatha kutha ndi matenda a shuga, mwachitsanzo, chifukwa chamankhwala omwe amapezeka ndi insulin. Odwala ayenera kudziwitsidwa izi zisanachitike.

Muzochitika zamankhwala odwala beta-blockers, matenda ashuga, kupweteka kwa shuga, kusintha kapena kutchulika kwenikweni kwa matchulidwe a hypoglycemia ndikotheka.

Anthu odwala matenda ashuga ketoacidosis ndi hyperglycemia amatha kupanga mankhwala osakwanira kapena kusiya kumwa mankhwala.

Kulephera kwa hepatatic kapena aimpso, kusakwanira kwa chithokomiro, chithokomiro cha pituitary kapena gland ya adrenal kungachepetse kufunikira kwa insulin. Matenda opsinjika kwambiri komanso matenda ena, m'malo mwake, angakulitse kufunika kwa insulin. Mukamasintha zakudya zamagulu owonjezera kapena kuchita zolimbitsa thupi, mungafunikire kusintha kwa mlingo.

Kugwiritsa ntchito mankhwala osokoneza bongo a insulin ndi mankhwala a gulu la thiazolidinedione kumawonjezera mwayi wokhala ndi matenda a mtima komanso edema, makamaka ndi matenda amtima komanso kupezeka kwa zinthu zomwe zingathe chifukwa chodwala mtima.

Chifukwa cha kutukuka kwa hypoglycemia, odwala ayenera kusamala nthawi yamankhwala akamagwiritsa ntchito makina kapena magalimoto oyendetsa.

Kuyanjana kwa mankhwala osokoneza bongo

• thiazide diuretics, mahomoni okhala ndi chithokomiro, mankhwala a phenothiazine, mankhwala omwe amalimbikitsa kuchuluka kwa shuga m'magazi, nicotinic acid, glucocorticosteroids, kulera kwapakamwa, chlorprotixen, lithium carbonate, beta-2-adrenergic agonists, danazol, isoniazid
• hypoglycemic mankhwala m'kamwa, guanethidine, anabolic mankhwala, muzikangana wa angiotensin II zolandilira, angiotensin akatembenuka enzyme zoletsa, octreotide, mankhwala a sulfa mankhwala fenfluramine, antidepressants ena (monoamine oxidase zoletsa), tetracyclines, Mowa ndi etanolsoderzhaschie mankhwala, beta-blockers, salicylates (acetyl salicylic ndi zina zotero. p.): ingachepetse kufunikira kwa insulin,
• reserpine, clonidine, beta-blockers: amatha kubisa mawonetseredwe a zizindikiro za hypoglycemia.

Zofanizira za Humulin NPH ndi Rosinsulin S, Rinsulin NPH, Protafan HM, Protamine-Insulin ChS, Insuman Bazal GT, Gensulin N, Vozulim-N, Biosulin.