Tresiba insulin: ndemanga za anthu odwala matenda ashuga za mankhwalawa

a Hypoglycemia Yotsimikizika ndi gawo la hypoglycemia, lomwe limatsimikiziridwa ndi muyeso wa magazi glucose concentration B Episode ya hypoglycemia pambuyo pa sabata la 16 la mankhwalawa Palibe kupangika kwakukulu kwa ma antibodies a insulin pambuyo pa chithandizo cha Tresiba Penfill ® kwa nthawi yayitali.

Pharmacokinetics

Mafuta
Kuchita kwapamwamba kwambiri kwa insulin degludec kumachitika chifukwa cha kupangidwa kwake molekyu. Pambuyo pa jekeseni wa subcutaneous, masheji ambiri osunthika amapangidwa, omwe amapanga insulin depot mu subcutaneous adipose minofu. Ma Multihexamers amapatuka pang'onopang'ono, ndikumasulidwa kwa zipludec insulin monomers, zomwe zimapangitsa kuti mankhwalawo atulutsidwe pang'onopang'ono komanso nthawi yayitali m'magazi.
Kufanana kwa ndende ya Tresiba m'magazi am'magazi kumatheka patatha masiku awiri atatha kupatsidwa mankhwala.
Kuchita kwa insulin degludec kwa maola 24 ndi kayendetsedwe kake ka tsiku lililonse kamodzi patsiku kumagawidwa chimodzimodzi pakati pa nthawi yoyamba ndi yachiwiri ya maola 12 (AUC_{GIR, 0-12h, SS} / Auc_{GIR, T, SS} = 0,5).

Kugawa
Kulumikizana kwa insulin degludec ndi mapuloteni a plasma (albumin) ndi> 99%.

Kupenda
Kuwonongeka kwa insulin degludec ndikufanana ndi insulin yamunthu, ma metabolites onse omwe amapangidwa satha ntchito.

Kuswana
Hafu ya moyo pambuyo subcutaneous jakisoni wa mankhwala a Tresiba ® Penfill ® amatsimikiza ndi muyeso wa mayamwidwe subcutaneous minofu.
Hafu ya moyo wa mankhwala a Tresiba ® Penfill ® ndi pafupifupi maola 25 ndipo sizodalira mlingo.

Chotsogola
Ndi subcutaneous makonzedwe, onse plasma wozungulira anali mogwirizana ndi mlingo kutumikiridwa mu osiyanasiyana achire Mlingo.

Magulu apadera a odwala
Panalibe kusiyana kulikonse pamachitidwe a pharmacokinetic a mankhwala a Tresiba ® Penfill ® kutengera mtundu wa odwala.

Okalamba okalamba, odwala mafuko osiyanasiyana, odwala omwe ali ndi vuto laimpso kapena kwa chiwindi
Palibe kusiyana kwakukulu pamankhwala komwe kunapezeka mu pharmacokinetics ya degludec insulin pakati pa odwala okalamba ndi achinyamata, pakati pa odwala amitundu yosiyanasiyana, pakati pa odwala omwe ali ndi vuto laimpso ndi kwa chiwindi, komanso odwala athanzi.

Ana ndi achinyamata
The pharmacokinetic katundu wa insulin degludec mu kafukufuku wa ana (6-11 wazaka) ndi achinyamata (wazaka 12-18) wokhala ndi mtundu 1 matenda a shuga ndi ofanana ndi omwe ali ndi odwala akuluakulu. Poyerekeza ndi kukhazikitsidwa kamodzi kwa mankhwalawa kwa odwala omwe ali ndi matenda a shuga 1, zimawonetsedwa kuti kuwonetsa kwa mankhwalawa kwa ana ndi achinyamata ndi kwapamwamba kuposa komwe kumachitika kwa achikulire.

Preclinical Safe Study Data

Zambiri zam'mbuyomu zochokera kumaphunziro a chitetezo cha mankhwala, kuwopsa kwa Mlingo wobwereza, kuchuluka kwazowopsa, zovuta zakuwonekera pakubala, sizinawululire vuto lililonse la insludec insulin kwa anthu.

Gwiritsani ntchito panthawi yoyembekezera komanso poyamwitsa

Kugwiritsira ntchito kwa mankhwala a Tresiba ® Penfill ® pa nthawi ya pakati kumapangidwa, chifukwa palibe chidziwitso chachipatala chogwiritsira ntchito pakubala.
Kafukufuku wokhudzana ndi kubereka mu nyama sikunawonetse kusiyana pakati pa insludec insulin ndi insulin yaumunthu molingana ndi embryotoxicity ndi teratogenicity.

Nthawi yoyamwitsa

Kugwiritsa ntchito kwa mankhwala a Tresiba ® Penfill ® pa nthawi yoyamwitsa kumatsutsana, chifukwa palibe chidziwitso chazachipatala chogwiritsa ntchito popaka akazi.
Kafukufuku wazinyama adawonetsa kuti mu makoswe, degludec insulin imachotsedwa mkaka wa m'mawere, ndipo kuchuluka kwa mankhwala mkaka wa m'mawere kumatsika kuposa plasma yamagazi.
Sizikudziwika ngati insulin degludec imachotsedwa mkaka wa amayi.

Chonde

Kafukufuku wazinyama sanapeze zovuta za degludec insulin pa chonde.

Mlingo ndi makonzedwe

Mlingo woyambirira wa mankhwalawa Tresiba ® Penfill ®

Odwala a shuga a 2
Mlingo woyamba wa Tresiba Penfill ® womwe ndi woyenera tsiku lililonse ndi magawo khumi, kenako osankhidwa ndi mtundu wa mankhwalawa.

Odwala Awa Matenda Ati Ashuga
Mankhwala Tresiba ® Penfill ® amalembedwa kamodzi patsiku limodzi ndi prandial insulin, yomwe imayendetsedwa ndi chakudya, kenako ndikusankhidwa kwa munthu.

Chotsani kuchokera kukonzekera kwina kwa insulin
Kuyang'anira mosamala kuchuluka kwa shuga m'magazi mukusamutsidwa komanso mu milungu yoyamba yopanga mankhwala atsopano ndikulimbikitsidwa.Pangakhale kofunikira kukonza concomitant hypoglycemic therapy (mlingo ndi nthawi ya makonzedwe apafupipafupi ndi ultrashort insulin kapena mlingo wa PHGP).

Odwala a shuga a 2
Mukasamutsa kwa Tresiba ® Penfill ® okonzekera odwala omwe ali ndi mtundu wachiwiri wa shuga omwe ali pa basal kapena basal-bolus regimen of insulin Therapy, kapena pamankhwala othandizira omwe ali ndi insulini osakanikirana / insulini zosakaniza nokha, muyezo wa Tresiba ® Penfill ® uyenera kuwerengedwa potengera mlingo wa basulin insulin , yomwe wodwalayo adalandira asanasamalidwe ku mtundu watsopano wa insulin, malinga ndi mfundo ya "unit unit", kenako ndikusintha mogwirizana ndi zosowa za wodwalayo.

Odwala Awa Matenda Ati Ashuga
Odwala ambiri omwe ali ndi matenda a shuga 1 a mtundu wa mellitus, akasintha kuchokera ku insulin iliyonse kupita ku Tresiba Penfill ®, mfundo ya unit-to-unit imagwiritsidwa ntchito potengera mlingo wa basal insulin yomwe wodwala adalandira asanasanduke, ndiye kuti mlingo umasintha malinga ndi zofunikira zake. Odwala omwe ali ndi matenda a shuga 1 a mtundu wa mellitus, omwe panthawi ya kusinthira kukachira ndi Tresiba ® Penfill ® anali pamankhwala a insulini ndi basal insulin mu regimen ya kawiri tsiku lililonse, kapena odwala HbA_1C® Penfill ® iyenera kukhazikitsidwa payokha. Mungafunike kuchepetsedwa kwa mlingo, motsatiridwa ndi kusankha kwa mankhwalawa kutengera matendawa.

Malamulo osinthika a dosing
Kutengera zosowa za wodwala, mankhwalawa Tresiba ® Penfill ® amakupatsani mwayi wosintha nthawi yake (onani gawo la Pharmacodynamics). Pankhaniyi, nthawi pakati pa jakisoni iyenera kukhala osachepera maola 8.
Ndikulimbikitsidwa kuti odwala omwe amaiwala kuyambitsa yomweyo insulin atalowa mankhwalawo, kenako abwerere ku nthawi yawo yonse kukonzekera mankhwalawa tsiku lililonse.

Magulu apadera a odwala

Okalamba okalamba (woposa zaka 65)
Tciousba ® Penfill ® ikhoza kugwiritsidwa ntchito mwa odwala okalamba. Magazi a shuga wamagazi amayenera kuyang'aniridwa mosamala ndi mlingo wa insulin kuti usinthidwe payekha (onani gawo la Pharmacokinetics).

Odwala ndi mkhutu aimpso ndi kwa chiwindi ntchito
Tresiba ® Penfill ® ikhoza kugwiritsidwa ntchito mwa odwala omwe ali ndi vuto la impso komanso kwa chiwindi. Magazi a glucose amayenera kuyang'aniridwa mosamala komanso mlingo wa insulin payokha ikusintha (onani gawo la Pharmacokinetics).

Ana ndi achinyamata
Zambiri zomwe zapezeka mu pharmacokinetic zimawonetsedwa m'gawo lachi Pharmacokinetics, komabe, kufunikira ndi chitetezo cha Tresiba Penfill ® mwa ana ndi achinyamata sizinaphunziridwe, ndipo malingaliro pa kumwa kwa mankhwalawa mu ana sanapangidwe.

Njira yogwiritsira ntchito
Tresiba ® Penfill ® idapangidwa kuti izingoyendetsa zochitika zokha. Mankhwala Tresiba ® Penfill ® sangathe kutumikiridwa kudzera m'mitsempha, chifukwa izi zimatha kuyambitsa hypoglycemia. Tresiba ®
Penfill ® sayenera kutumikiridwa intramuscularly, chifukwa pamenepa mayamwidwe amasintha mankhwalawa. Tresiba ® Penfill ® singagwiritsidwe ntchito pamapampu a insulin.
Tresiba ® Penfill ® imayendetsedwa mosagwirizana m'tchafu, kukhoma kwam'mimba khoma kapena phewa. Masamba obayira amayenera kusinthidwa pafupipafupi m'dera lomwelo kuti muchepetse vuto la lipodystrophy. Cartridge ya Penfill ® idapangidwa kuti igwiritsidwe ntchito ndi NovoFine ® kapena NovoTvist ® singano yamagetsi imodzi ndi njira za Novo Nordisk insulin.

Kodi Treshiba imagwiritsidwa ntchito liti?

Zizindikiro zazikulu kuti ayambe kugwiritsa ntchito mankhwalawa ndizosakhazikika shuga komanso magazi. Zizindikiro zotere zimatha kuchitika kawiri komanso kukalamba. Matendawa ndi oti mlandu - matenda ashuga.

Kutengera zomwe amakonda ndi momwe thupi limagwiritsira ntchito mankhwalawa, akatswiri amapereka mankhwala ena, mogwirizana ndi Tresiba.

Mankhwalawa omwe amafunsidwa kale amapangidwira odwala matenda ashuga ndi mtundu wachiwiri wa matenda, koma pofufuza mosamala, komanso kusintha kwa maselo, mankhwalawa angagwiritsidwe ntchito ngati oyamba.

Mukamagwiritsa ntchito analog ya Degludek, yomwe imatchedwa Tresiba, kulumpha kolimba sikuloledwa kwa maola 24. Pogwiritsa ntchito mankhwalawa, madokotala amatha kukwaniritsa zotsatira zabwino, kuchepetsa shuga panthawi ya chithandizo.

Chifukwa chake ntchito zofunika kwambiri za odwala ambiri zimayenda bwino. Anthu ambiri amadziwa kuti ngati shuga amasungika kwambiri, ndiye kuti ziwalo zamkati zimatha kuvutika kwambiri, ndipo izi zimabweretsa zotsatirapo zowopsa.

Kusiyana kwakukulu ndi mankhwala ena ndi zotsatira zake zazitali. Izi zimachepetsa chiopsezo cha hypoglycemia. Tinthu tating'onoting'ono ta mankhwalawo sasiyana kwenikweni ndi insulin ya munthu. Amathanso kuphatikiza m'molekyu akuluakulu, motero amakhala ndi malo osungirako.

Zotsatira zimachitika pafupifupi mukangomwa mankhwala. Mwanjira ina, pa jakisoni, mtundu wa kudzikundikira kwachuma kwa odwala kumachitika, ngati pakufunika, umagwiritsidwa ntchito kuchepetsa shuga.

Zotsatira zoyipa

Kufotokozera kwamomwe munthu amakumana ndi vuto la chitetezo chamthupi
Mukamagwiritsa ntchito mankhwala a insulin, thupi lanu limakumana ndi vuto. Matupi amtundu wamtundu wina pakukonzekera kwa insulin yokha kapena zinthu zina zothandiza zomwe zimapanga zomwe zitha kuwononga moyo wa wodwalayo.
Mukamagwiritsa ntchito mankhwala a Tresiba ® Penfill ® hypersensitivity reaction (kuphatikizapo kutupa kwa lilime kapena milomo, kutsegula m'mimba, mseru, kutopa ndi kuyabwa pakhungu) ndi urticaria sizinali zachilendo.

Hypoglycemia
Hypoglycemia imatha kukhala ngati mlingo wa insulin ndiwokwera kwambiri poyerekeza ndi kufunikira kwa insulin. Hypoglycemia yambiri ikhoza kuyambitsa kusokonezeka kwa chikumbumtima komanso / kapena kukhumudwa, kuwonongeka kwakanthawi kapena kosasinthika kwa ubongo kugwira ntchito mpaka pakufa. Zizindikiro za hypoglycemia, monga lamulo, zimayamba mwadzidzidzi. Izi zimaphatikizapo thukuta lozizira, kutsekeka kwa khungu, kutopa kwambiri, manjenje kapena kunjenjemera, nkhawa, kutopa kwambiri kapena kufooka, kusokonezeka, kuchepa, kugona, kugona kwambiri, kusawona bwino, kupweteka mutu, nseru, palpitations.

Lipodystrophy
Lipodystrophy (kuphatikiza lipohypertrophy, lipoatrophy) imatha kupezeka pamalo opangira jekeseni. Kutsatira Malamulo osintha jakisoni mkati mwanu momwemo kumathandizira kuti muchepetse chiopsezo chodzetsa vuto ili.

Zokhudza malo jakisoni
Odwala omwe adathandizidwa ndi Tresiba ® Penfill ® adawonetsa malo omwe amapezeka jakisoni (hematoma, ululu, hemorrhage, erythema, zotupa zamagetsi zotupa, kutupa, kusinthika kwa khungu, kuyabwa, kusokonekera komanso kukhazikika m'malo a jekeseni). Zambiri zomwe zimachitika jekeseni malo ndizochepa komanso zakanthawi ndipo nthawi zambiri zimatha pomapitilira chithandizo.

Ana ndi achinyamata
Makhalidwe a pharmacokinetic a mankhwala a Tresiba ® Penfill ® anaphunziridwa mwa ana ndi achinyamata osakwana zaka 18 (onani gawo la Pharmacokinetics). Kafukufuku wokhudza kuyendetsa bwino chitetezo cha insulin degludec mwa ana ndi achinyamata sichinachitike.

Magulu apadera a odwala
Panthawi ya mayesero azachipatala, palibe kusiyana komwe kunapezeka pakadutsa, mtundu, kapena kuopsa kwa magwiridwe antchito pakati pa odwala okalamba ndi odwala omwe ali ndi vuto laimpso kapena kwa chiwindi ndi ambiri odwala.

Kodi mankhwalawa amagwira ntchito bwanji?

Zomwe zimakhazikitsidwa ndimankhwala ndizomwe zimagwira, zomwe zimatha kukhala ndi mphamvu yachilendo m'thupi, motero kusintha kuchuluka kwa shuga m'magazi. Katundu wamkulu amachita ngati Levemir, Lantus, Apidra ndi Novorapid. Treshiba insulin kwenikweni ndi analogue ya munthu mahomoni.

Poyerekeza insulin yachilengedwe, Tresiba ndiye mankhwala othandiza kwambiri komanso odalirika. Ndipo zomwe ndizofunikira ndizakuti palibe zoletsa kugwiritsa ntchito, popeza kupangidwa kwa insulin yapadera ndikoyenera pafupifupi aliyense.

Mankhwala amathandizanso thupi la wodwala, kutengera mphamvu za asayansi amakono. Zotsatira zake zidakwaniritsidwa pogwiritsa ntchito biotechnology kuphatikizanso DNA ndi mavuto a Saccharomyces cerevisiae. Nthawi yomweyo, maselo ambiri opanga maselo anapangidwa.

Masiku ano, odwala omwe ali ndi mtundu woyamba kapena wachiwiri wa matenda amatha, popanda kukayikira, angagwiritse ntchito Treshiba insulin kuti achepetse ndikuwongolera shuga.

Zomwe zikuchitikira thupi:

• Chodabwitsa chazomwe zimachitika ndi mankhwalawa ndikuti mamolekyulu ake amatha kuphatikiza ma mamolekyulu akulu. Izi zimachitika pafupifupi mutangoyambitsa kuphatikizika kwa khungu. Mu thupi, chinthu monga insulin depot chimapangidwa. Imakhala ndi gawo la insulin yokhazikika,
• Mphamvu yotalikirapo imakwaniritsidwa chifukwa cha Mlingo wochepa - ndiwothandiza kuposa insulin, yomwe idagwiritsidwa ntchito kale.

Tresiba insulin ndi mlingo wake woyenera

Mankhwalawa amaperekedwa kokha pakhungu, ndizoletsedwa kupaka minofu. Ponena za kayendetsedwe ka kayendetsedwe kake, njirayi imachitika kamodzi pakatha maola 24 aliwonse. Palibe mikangano ndi mankhwala ena omwe amachitika. Insulin imagwiritsidwa ntchito limodzi ndi mapiritsi omwe amagwiritsidwa ntchito kupititsa patsogolo shuga kapena ndi insulini ina.

Tresiba imayikidwa ngati mankhwala odziimira pawokha kapena kuphatikiza ndi mankhwala ena kuti akwaniritse zotsatira zake. Ngati insulin yomwe ikufunsidwayo siyidapatsidwepo kwa odwala matenda ashuga, mlingo woyambirira sudzakhala wopitilira magawo 10. Pambuyo pake, kusintha koyenera kumachitika, kutengera zotsatira ndi zosowa za aliyense payekha.

Zikachitika kuti munthu walembedwa kale mtundu wina wa insulini, koma kusamutsira ku Treshiba ndikofunikira, mlingo woyambirira ukhale womwewo. Pambuyo pake, mutha kusintha zina ndi madokotala.

Ngati munthu akudwala matenda ashuga amagwiritsa ntchito mitundu iwiri ya mankhwala operekera mankhwala kapena odwala glycated hemoglobin ali ndi magawo 8% kapena kuchepera, mlingo umayikidwa payekhapayekha. Zimachitika kuti mlingo wafupika. Mulimonsemo, mlingo umayenera kusankhidwa ndi akatswiri, poganizira zotsatira ndi zomwe munthu payekha ali nazo m'thupi.

Tresiba insulin ndi mapindu ake

Poganizira ziwerengero zamankhwala zomwe zilipo, Tresiba kwenikweni sikuti imayambitsa hypoglycemia. Izi zikuwonetsedwa ndi ndemanga zambiri za odwala.Ngati mutsatira malingaliro onse a madotolo ndi malamulo a malangizo, ndiye kuti palibe madontho mumagazi omwe amapezeka.

Ubwino wa Tresiba:

• chiopsezo chochepa cha glycemia masana, poyerekeza ndi mitundu ina ya insulin,
• Chachilendo cha mankhwala a Tresiba ndikuti ma endocrinologists ambiri amatha kukhazikitsa mlingo woyenera, payekhapayekha kwa wodwala aliyense.

Mothandizidwa ndi Treshiba, mutha kukwanitsa kubwezera bwino njira zothandizira matenda am'magazi, izi zimathandizira kukonza bwino thanzi la odwala, ndikupangitsa kuti ikhale yolimba. Ndikofunika kudziwa kuti palibe zoyipa zomwe zimachitika. Izi zikuwonetsedwa ndi kuwunika koyenera kwa odwala.

Tresiba imathandizira odwala omwe ali ndi matenda ashuga

Momwe mungapangire mankhwalawa?

Kuchokera pazomwe zanenedwa pamwambapa, zitha kutsimikiziridwa kuti mankhwalawa amapangidwira kukonzekera kwa subcutaneous pafupipafupi 1 nthawi patsiku. Ngati wodwala sanalowetse insulin yatsopano, koma atagwiritsa ntchito mtundu wina wa insulin, tikulimbikitsidwa kuti tiyambe ndi mlingo wosaposa magawo 10 tsiku lonse.

Mukasamutsa mtundu wina wa insulin kupita ku wina watsopano, ndibwino kugwiritsa ntchito mlingo wochepa, kenako ndikusintha kuti mupeze zotsatira zabwino.

Kodi pali zolakwika zilizonse ku Tresib insulin?

Kuphatikiza poti mankhwalawa ali ndi zabwino zambiri, zovuta zomwe zilipo.

Choyambirira chomwe muyenera kudziwa ndikulephera kugwiritsa ntchito malonda mudakali achichepere. Komanso ndizoletsedwa kwa amayi apakati ndi amayi oyamwitsa. Choyipa chake ndikuti Treshib silingagwiritsidwe ntchito molimba.

Kukhazikitsidwa kwa mankhwalawa kwa amayi apakati ndi koletsedwa

Mankhwalawa ndiwatsopano komanso, kupatula mphamvu zake ndi zabwino zake za mitundu ina ya insulini, sichitha nthawi. Mpaka pano, chiyembekezo chambiri chapatsidwa chida chatsopano chowongolera ndi kutsitsa shuga m'magazi, koma sizikudziwikiratu zomwe zidzachitike mu zaka 6-8, chifukwa pali chiwopsezo cha zovuta zilizonse.

Ndikofunikira kudziwa kuti, monga mankhwala ena, Tresiba ikhoza kuyambitsa zovuta zonse, zimatengera mawonekedwe amunthu. Izi zikachitika, ndiye kuti chida sichikulimbikitsidwa.

Mavuto omwe amafotokozedwa ndikuti mankhwalawo sioyenera kuphatikiza mawonekedwe awa:

• mawonekedwe a anaphylactic mantha,
• zotupa mwachangu
• mawonekedwe a urticaria ndi zofananira,
• lipodystrophy,
• kuchitapo kosavuta kumva kwa thupi mu mawonekedwe a kuyimitsidwa kwanuko kapena kutupa,
• mawonekedwe a mafupa, zikwapu kapena zisindikizo pakhungu.

Opikisana nawo

Wampikisano waku Treshiba ndi Lantus. Insulin yamtunduwu imagwiritsidwanso ntchito kamodzi patsiku ndipo imakhala yolimba. Malinga ndi zotsatira za kafukufuku wokhudzana ndi zamankhwala pakati pa mankhwalawa, zidatsimikiziridwa kuti a insulin Tresiba ndi Lantus amatha kulimbana mofanananso ndi ntchito yoyang'anira kuchuluka kwa shuga m'magazi.

Koma pali kusiyana pakati pa mankhwalawa. Mukamagwiritsa ntchito Treshiba, mlingo umachepetsedwa pafupifupi 20-25%. Mwanjira ina, ndiopindulitsa pachuma.

Chidule

Mashuga a shuga usiku - iyi ndiye vuto lalikulu kwambiri la anthu odwala matenda ashuga. Ndipo pakakhala kuti palibe njira yowunikira, ndiye kungoitanira akatswiri okha kumathandizanso. Pachifukwa ichi, tikulimbikitsidwa kuti muziganiza pasadakhale za kugona mwamtendere ndi matenda ashuga pogwiritsa ntchito mankhwala omwe atsimikiziridwa.

Madokotala amayenera kuyesetsa kusankha kwawo, poganizira mbali zambiri za thupi.

Makhalidwe ndi katundu wa Tresib insulin

Ma insulin omwe amakhala kwa nthawi yayitali amagwiritsidwa ntchito kuti azikhala ndi mahomoni ambiri amtundu 1 komanso matenda amitundu iwiri. Mankhwalawa akuphatikizapo Tresiba yopangidwa ndi Novo Nordisk.

Tresiba ndi mankhwala ozikidwa ndi mahomoni ofanana kwambiri.

Ndi analogue yatsopano ya basal insulin.Imapereka chiwonetsero chofananira cha glycemic ndi chiopsezo chocheperako cha nocturnal hypoglycemia.

Zina mwa mankhwalawa zimaphatikizapo:

• shuga wokhazikika komanso wosalala
• Chitani zoposa maola 42
• kusinthasintha kocheperako
• kuchepetsa shuga
• mbiri yabwino yachitetezo
• kuthekera kwa kusintha pang'ono panthawi ya insulin popanda kuvulaza thanzi.

Mankhwalawa amapangidwa ngati ma cartridgeges - "Tresiba Penfil" ndi cholembera, pomwe makatoni amatsekedwa - "Tresiba Flexstach". Chothandizira chophatikizika ndi insulin Degludec.

Degludek amamanga pambuyo pa utsogoleri wamafuta ndi minofu ya m'mimba. Pali kulowetsa pang'onopang'ono komanso mosalekeza kulowa m'magazi. Zotsatira zake, kutsika kwamphamvu kwa glucose kumapangidwa.

Mankhwalawa amalimbikitsa kuyamwa kwa glucose ndi minyewa komanso kuletsa kwake kutulutsa kwa chiwindi. Ndi kuchuluka Mlingo, kutsitsa-shuga kumachulukanso.

Kuphatikizika kwa mahomoni ofanana kumapangidwa pafupifupi pakatha masiku awiri ogwiritsira ntchito. Kufunikira kwazinthu kumatha maola opitilira 42. Kutha theka moyo kumachitika mu tsiku.

Zisonyezero zogwiritsidwa ntchito: mtundu 1 ndi 2 shuga mwa akulu, shuga kwa ana 1 chaka.

Kutsutsana kutenga Tresib insulin: ziwengo kwa zigawo zikuluzikulu za mankhwala, Degludek tsankho.

Malangizo ogwiritsira ntchito

Mankhwalawa amaperekedwa nthawi yomweyo. Kulandila kumachitika kamodzi patsiku. Odwala omwe ali ndi matenda amtundu wa 1 amagwiritsa ntchito Degludek kuphatikiza ndi insulin yochepa kuti isafunike pakudya.

Odwala omwe ali ndi matenda ashuga amatenga mankhwalawo mosatengera chithandizo chowonjezera. Tresiba imayendetsedwa padera komanso mosakanikirana ndi mankhwala oikidwa pompopompo kapena insulini ina. Ngakhale kusinthasintha posankha nthawi yoyang'anira, nthawi yocheperako iyenera kukhala osachepera maola 8.

Mlingo wa insulin umakhazikitsidwa ndi adokotala. Amawerengeredwa potengera zosowa za wodwala mu timadzi tating'onoting'ono pakayankhe glycemic. Mlingo woyenera ndi magawo 10. Ndi kusintha kwa zakudya, katundu, kukonza kwake kumachitika. Ngati wodwala wodwala matenda a shuga 1 amatenga insulin kawiri pa tsiku, kuchuluka kwa insulini komwe kumayendetsedwa kumatsimikiziridwa payekhapayekha.

Mukasinthira ku Tresib insulin, kuchuluka kwa shuga kumayendetsedwa kwambiri. Chidwi chachikulu chimaperekedwa kuzizindikiro mu sabata yoyamba kumasulira. Chiwerengero chimodzi kapena chimodzi kuchokera pa mulingo woyamba wa mankhwalawa umayikidwa.

Tresiba imabayidwa pang'onopang'ono m'malo otsatirawa: ntchafu, phewa, khoma lakutsogolo kwam'mimba. Pofuna kupewa kukwiya komanso kuperewera, malowa amasintha mosamala m'deralo.

Sizoletsedwa kugwiritsira ntchito timadzi mwamkati. Izi zimakwiyitsa kwambiri hypoglycemia. Mankhwalawa sagwiritsidwa ntchito popukutira mapiritsi ndi kulowetsedwa. Kupusitsa komaliza kumatha kusintha kuchuluka kwa mayamwidwe.

Zofunika! Musanagwiritse ntchito cholembera, langizo limachitika, malangizowo amaphunziridwa mosamala.

Malangizo pavidiyo ogwiritsa ntchito cholembera:

Zotsatira zoyipa ndi bongo

Mwa zina zoyipa zomwe odwala atenga Tresiba adachita, ndi izi:

• hypoglycemia - nthawi zambiri
• lipodystrophy,
• zotumphukira edema,
• thupi siligwirizana
• zimachitika malo opakidwa jakisoni,
• chitukuko cha retinopathy.

Mukamamwa mankhwalawa, hypoglycemia ya zovuta zosiyanasiyana imatha kuchitika. Njira zosiyanasiyana zimatengedwa kutengera mkhalidwe.

Ndi kuchepa pang'ono kwa glycemia, wodwalayo amamwa 20 g shuga kapena zinthu zomwe zili nazo. Ndikulimbikitsidwa kuti nthawi zonse mumanyamula shuga mulingo woyenera.

Woopsa, womwe umachitika limodzi ndi kuwonongeka kwa chikumbumtima, IM glucagon imayambitsidwa. Osasinthika, shuga amayamba. Wodwalayo amayang'aniridwa kwa maola angapo. Kuti muchepetse kubwereranso, wodwala amatenga chakudya chamafuta.

Odwala Apadera ndi Mayendedwe

Zomwe amamwa mankhwalawa pagulu lapadera la odwala:

1. Tresiba amavomerezedwa kuti azigwiritsidwa ntchito ndi okalamba. Gulu ili la odwala liyenera kuwonetsetsa kuchuluka kwa shuga pafupipafupi.
2. Palibe maphunziro pazotsatira za mankhwalawa panthawi yomwe ali ndi pakati. Ngati adaganiza kuti amwe mankhwalawo, ndikofunikira kuti kuwunikira kuwonetsa zizindikiro, makamaka mu 2nd ndi 3 trimester.
3. Palibenso chidziwitso cha mankhwalawa panthawi ya mkaka wa mkaka. Mukudyetsa ana akhanda, zoyipa sizinawonedwe.

Mukamatenga, kuphatikiza kwa Degludek ndi mankhwala ena kumaganiziridwa.

Anabolic steroids, ACE inhibitors, sulfonamides, adrenergic blockers, salicylates, piritsi lotsika shuga piritsi, mao inhibitors amachepetsa shuga.

Mankhwala omwe amachulukitsa kufunika kwa mahomoni amaphatikizapo sympathomimetics, glucocorticosteroids, Danazole.

Mowa umatha kusokoneza zochita za Degludek onse pakuwonjezera ndikuchepetsa ntchito yake. Ndi kuphatikiza kwa Tresib ndi Pioglitazone, kulephera kwa mtima, kutupa kumatha kukhazikika. Odwala amayang'aniridwa ndi dokotala panthawi yamankhwala. Ngati mtima wasokonekera, mankhwalawa amasiya.

Mu matenda a chiwindi ndi impso pa mankhwalawa ndi insulin, munthu ayenera kusankha mankhwalawa. Odwala ayenera kuwongolera shuga pafupipafupi. Mu matenda opatsirana, dysfunctions ya chithokomiro, kupanikizika kwa mitsempha, kufunika kwa kusintha kwamphamvu kwa mlingo.

Zofunika! Simungasinthe popanda kumwa kapena kuletsa mankhwalawo kuti mupewe hypoglycemia. Ndi dokotala yekhayo amene amakupatsirani mankhwalawo ndikuwonetsa mawonekedwe ake

Mankhwala omwe ali ndi vuto lofananalo, koma ali ndi chinthu china chogwira ntchito, akuphatikizapo Aylar, Lantus, Tujeo (insulin Glargin) ndi Levemir (insulin Detemir).

Poyerekeza Tresib ndi mankhwala ofananawo, magwiridwe omwewo adatsimikizika. Phunziroli, panali kusowa kwa shuga, mwadzidzidzi kuchuluka kwa hypoglycemia.

Umboni wa anthu odwala matenda ashuga umaperekanso umboni wa kutha kwa Treshiba. Anthu amadziwa kusintha kosavuta kwa mankhwalawo komanso chitetezo chake. Zina mwazovuta zomwe zili pamtengo wamtengo wapatali wa Degludek.

Tresiba ndi mankhwala omwe amapereka basal secretion ya insulin. Ili ndi mbiri yotetezeka ndipo imachepetsa shuga. Kuunika kwa odwala kumatsimikizira kuyenera kwake komanso kukhazikika kwa kuchitapo kanthu. Mtengo wa Tresib insulin ndi pafupi ma ruble 6000.

Adalimbikitsa Zolemba Zina Zogwirizana

Tresiba - Kuwona Tresiba

Tresiba ndi mankhwala a insulin omwe amagwiritsidwa ntchito pa matenda ashuga. Chithandizo chophatikizika cha mankhwalawa chimapangidwa ndi njira zamakono zamankhwala amitundu mitundu - ndi chithunzi chonse cha insulin ya anthu.

Pazogawika zamankhwala osokoneza bongo monga kuthamanga kwa nthawi komanso nthawi yayitali ya Tresib, zimatanthauzira zazitali kwambiri.

Mwanjira ina, pambuyo pa dosing, gawo lokhazikika la mankhwalawo limadzimangira ku insulin receptors ndikuyambitsa kuchepa kwakutali kwa ndende ya magazi m'magazi a wodwalayo.

Imagwiritsidwa ntchito pamene:

• Type 1 ndi Type 2 shuga mwa achikulire omwe amachita mosiyanasiyana ndi insulin,

Tresib imapangidwa monga njira yankho pama cartridgeges omwe amagwiritsidwa ntchito mujekeseni - omwe amatchedwa "zolembera". Jakisoni amachitika pang'onopang'ono - pakulunga khungu pakhungu, phewa kapena pamimba. Ngati wothandizirayu amathandizidwa kudzera m'mitsempha, munthu amakhala ndi vuto lalikulu la hypoglycemia, lomwe limakhudza thanzi la ziwalo zonse ndi machitidwe, ndipo limayambitsa kutsokomola.

Malangizo a Tresiba akuti amayenera kudulidwa kamodzi patsiku. Chifukwa cha izi, nthawi yoyenera imasankhidwa, yomwe imatsatiridwa popereka chithandizo. Ngati wodwala wasowa jakisoni, ndiye kuti ndikofunikira kuti mudzaze jakisoni posachedwa, kenako ndikubwerera.

Monga njira ina iliyonse yomwe imayendetsa shuga m'magazi, Trecib Therapy imayendetsedwa ndi glucometer. Mankhwalawa amatha kugwiritsidwa ntchito padera komanso kuphatikiza ndimankhwala ena a hypoglycemic.Posankha ndalama zina ndi Tresib, ndikofunikira kuti muthe kuyambiranso mlingo. Apa, monga lamulo, chiwembu cha unit-to-unit chimagwiritsidwa ntchito.

Ngati mukufuna kugwiritsa ntchito mankhwalawa kwa nthawi yoyamba, werengani malangizo okonzekera “cholembera” ndikutsatira malamulo onse pakugwiritsa ntchito.

Wolemba:

• Mimba komanso kuyamwa
• Kuthandiza odwala osakwana zaka 18,
• Kusagwirizana ndi mankhwalawo,

Zotsatira zoyipa ndi bongo

Zikuyembekezeka kuti nthawi zambiri odwala omwe akugwiritsa ntchito insulin amakonzekera, zotsatirazi zimachitika:

• hypoglycemia - kuchepa kwakukulu kwa kuchuluka kwa shuga m'magazi,
• kapena hyperglycemia - kuchuluka kwa shuga ndende kuposa zomwe zimachitika (mwachitsanzo, ndi insulin yokwanira),

Komanso, odwala nthawi zambiri amadandaula kuti zotsatira zosafunikira zimapezeka pamalo opangira jakisoni - kuphatikizika, kuphulika, kukwiya, ndi zina zambiri.

Ngati simusintha malo a jakisoni, thanzi la minofu yolumikizira imatha kukhala ndi vuto la lipodystrophy (kuwonongeka kwa minofu ya adipose).

Hypoglycemia imakhalanso choopsa chachikulu cha Tresib bongo. Ndi kuchepa pang'ono kwa shuga, wodwalayo amatha kulipirira podya maswiti, chidutswa cha shuga. Koma m'malo ovuta kwambiri, ndikutayika - kukhazikitsidwa kwa glucose kukonzekera ndikofunikira.

Analogs ndiotsika mtengo kuposa Tresib

Mankhwalawa alibe mwachindunji. Koma mankhwalawa amapereka ndalama zambiri kutengera insulin. Mwachitsanzo:

• Lantus
• Levemir,
• Gensulin
• Biosulin
• Kuphatikizanso insulini
• Khalid

Pafupifupi onsewo ndiotsika mtengo kuposa Tresib. Koma apa ndikofunikira kwambiri osati mtengo wake, koma kusintha kwa thupi la wodwalayo m'njira zosiyanasiyana. Ndi kwa iwo kuti dokotala amakhala wokhazikika, akumapereka mankhwala ena kuti achepetse shuga. Kuphatikiza apo, ambiri aiwo amaperekedwa kwa odwala malinga ndi malangizo aulere.

Ultra wa insulin Tresiba - mawonekedwe a ntchito ndi kuwerengera Mlingo

Tresiba ndiye insulin yayitali kwambiri yolembedwa mpaka pano. Poyamba, adapangira odwala omwe amakhalanso ndi insulin yawo, ndiye kuti, matenda a shuga a 2. Tsopano kugwiritsa ntchito bwino kwa mankhwalawo kumatsimikiziridwa kwa odwala matenda ashuga omwe ali ndi matenda a mtundu woyamba.

Tresibu yopangidwa ndi Danish nkhawa NovoNordisk. Komanso, zogulitsa zake ndi zachikhalidwe cha Actrapid ndi Protafan, zofananira zatsopano za insulin Levemir ndi NovoRapid.

Anthu odwala matenda ashuga omwe akudziwa zambiri amati Tresiba siwotsika kwambiri kuposa omwe adawatsogolera - Protafan ya nthawi yayitali pochita komanso lalitali Levemir, ndipo limapitirira kukhazikika kwawo ndikufanana pantchito.

Mfundo ya Treshiba yogwira ntchito

Kwa odwala matenda ashuga amtundu 1, kubwezeretsanso insulin yosowa ndi jakisoni wa ma hormone ofunikira ndikofunikira. Ndi mtundu wa 2 wodwala matenda a shuga, chithandizo cha insulin ndi chothandiza kwambiri, chovomerezeka komanso chodula. Chochitika chokhacho chofunikira kwambiri pakukonzekera insulin ndi chiopsezo cha hypoglycemia.

Moni Dzina langa ndine Galina ndipo sindilinso ndi matenda ashuga! Zinanditengera milungu itatu yokhakubwezeretsa shuga kwachikhalidwe komanso kusakhala mankhwala osokoneza bongo
>> Mutha kuwerenga nkhani yanga apa.

Kugwa kwa shuga ndizowopsa usiku, chifukwa zimatha kupezeka mochedwa kwambiri, kotero zofunika zachitetezo kwa ma insulin aatali zikupitilira kukula. Mu shuga mellitus, wokhazikika komanso wolimba, akapanda kusintha mphamvu ya mankhwalawo, amachepetsa chiopsezo cha hypoglycemia pambuyo pake.

Insulin Tresiba imakwaniritsa zolinga izi:

1. Mankhwalawa ndi a gulu latsopano lama insulini lalitali-lalitali, chifukwa limagwira ntchito motalikirapo kuposa ena onse, maola 42 kapena kupitilira apo. Izi ndichifukwa choti mamolekyulu osinthidwa "amamatira" pansi pa khungu ndipo amatuluka kulowa m'magazi pang'onopang'ono.
2. Maola 24 oyambilira, mankhwalawa amalowa m'magazi momwemonso, zotsatira zake zimachepa bwino.Peak kuchitapo sikikupezeka konse, mbiriyo ndiyotsika.
3. Majakisoni onse amachita chimodzimodzi. Mutha kukhala otsimikiza kuti mankhwalawa amagwiranso ntchito monga dzulo. Zotsatira za Mlingo wofanana ndizofanana kwa odwala azaka zosiyanasiyana. Kusintha kwa machitidwe ku Tresiba ndi kokwana kanayi kuposa kwa Lantus.
4. Tresiba imakhumudwitsa 36% hypoglycemia kuposa ma insulin anthawi yayitali kuyambira nthawi ya 0:00 mpaka 6:00 ndi mtundu wa 2 shuga. Ndi matenda amtundu 1, phindu silodziwikiratu, mankhwalawa amachepetsa chiwopsezo cha nocturnal hypoglycemia ndi 17%, koma amachulukitsa chiopsezo cha hypoglycemia masana ndi 10%.

Chosakaniza chophatikizika cha Tresiba ndi degludec (munjira zina - degludec, the English degludec). Uku ndikuchita kuphatikizanso kwa insulin, momwe ma molekyulu amasinthidwa. Monga mahomoni achilengedwe, imatha kumangiriza ma cell receptors, imalimbikitsa kudutsa kwa shuga kuchokera m'magazi kulowa m'magazi, ndikuchepetsa kupanga shuga m'chiwindi.

Zothandiza Ndikofunikira kwambiri kusiyanitsa mitundu ya insulini, kuti mumve momwe zimakhalira komanso kusiyana kwake. Ikiye ahanjikile hakutwalaho kuzachisa jino jishimbi, oloze ikiye ahanjikile.

Chifukwa cha kapangidwe kake kosintha pang'ono, insuliniyi imapangika kuti ikhale yolimba mu cartridge. Pambuyo pakuyambitsa pansi pa khungu, imapanga mtundu wamtundu wa depot, womwe umakakamizidwa pang'onopang'ono komanso mwachangu, womwe umatsimikizira kukhathamira kwa mahomoni m'magazi.

Kuchokera pamawonedwe a physiology, omwe ali ndi matenda ashuga, Tresiba ndiwabwino kuposa insulin yonse yomwe imabwereza kutulutsa kwachilengedwe kwa mahomoni.

Kutulutsa Fomu

Mankhwala amapezeka m'mitundu itatu:

1. Tciousba Penfill - makatoni okhala ndi yankho, kugwiritsidwa ntchito kwa mahomoni mwa iwo ndi mulingo wanthawi zonse - U Insulin ikhoza kujambulidwa ndi syringe kapena kumaikidwa ma cartridge m'mapensulo a NovoPen ndi zina zofananira.
2. Tresiba FlexTouch yokhala ndi ndende U100 - syringe zolembera momwe makilogalamu 3 ml amakwezedwa. Cholembera chitha kugwiritsidwa ntchito mpaka insulini momwemo itatha. Cartridge m'malo sichinaperekedwe. Mlingo wa gawo - 1 unit, mlingo waukulu kwambiri wa kuyambitsa 1 - 80 mayunitsi.
3. Tresiba FlexTouch U200 - omwe adapangidwa kuti akwaniritse chosowa chowonjezereka cha mahomoni, nthawi zambiri awa ndi odwala omwe ali ndi matenda osokoneza bongo omwe ali ndi vuto lalikulu la insulin. Kuchuluka kwa insulin kumachulukitsa, kotero kuchuluka kwa yankho lomwe limayambitsidwa pansi pa khungu ndilochepa. Ndi cholembera, mutha kulowa kamodzi mpaka mayunitsi 160. mahomoni mukuwonjezeka kwa 2 mayunitsi. Makatoni okhala ndi kuchuluka kwa Refludec Palibe chifukwa chomwe mungatulutsire ma cholembera oyambilira ndi kuyika enawo, chifukwa izi zidzapangitsa kuti pakhale mankhwala osokoneza bongo okwanira komanso hypoglycemia yayikulu.

Ku Russia, mitundu itatu yonse ya mankhwalawa amalembetsedwa, koma m'masitolo am'magazi amapereka Tresib FlexTouch yokhazikika. Mtengo wa Treshiba ndiwokwera kuposa wazomera zina zazitali. Paketi yokhala ndi zolembera 5 za ma syringe (15 ml, ma unit 4500) imakhala ndalama kuchokera 7300 mpaka 8400 rubles.

Kuphatikiza pa degludec, Tresiba imakhala ndi glycerol, metacresol, phenol, zinc acetate. Acidity yothetsera imayandikira ndale chifukwa chowonjezera hydrochloric acid kapena sodium hydroxide.

Ndikofunikira kwambiri: Lekani kudyetsa mafia azakudya nthawi zonse. Ma Endocrinologists amatipangitsa kuti tiziwononga ndalama mopitilira mapiritsi pomwe shuga m'magazi amatha kukhala ngati ma ruble 143 ... >> werengani nkhani ya Andrey Smolyar

Zisonyezo zakusankhidwa kwa Tresiba

Mankhwalawa amagwiritsidwa ntchito limodzi ndi ma insulin othamanga othandizira am'magazi a mitundu yonse ya matenda a shuga. Ndi matenda 2 a mtundu, ndi insulin yayitali yokha yomwe ingafotokozedwe gawo loyamba.

Poyamba, malangizo a ku Russia omwe amagwiritsidwa ntchito adalola kugwiritsa ntchito Treshiba kokha kwa odwala akuluakulu.

Pambuyo pa maphunziro omwe amatsimikizira chitetezo chake chamoyo chokula, zosintha zidapangidwa ku malangizowo, ndipo tsopano zimalola kuti mankhwalawa azigwiritsidwa ntchito mwa ana kuyambira chaka chimodzi.

Mphamvu ya degludec pa mimba komanso kukula kwa makanda mpaka chaka sichinaphunzirepo, chifukwa chake, Tresib insulin sinafotokozeredwe magulu awa a odwala. Ngati wodwala matenda ashuga adanenanso kale kuti thupi lawo siligwirizana ndi Refludec kapena mbali zina za yankho, ndikofunikanso kupewa kumwa mankhwala a Tresiba.

Treshiba Insulin

Anayang'aniridwa ndi Arcadia, wazaka 44. Matenda a shuga a Type 1, ndimagwiritsa ntchito Treshiba insulin kwa mwezi umodzi. Tsopano, m'mawa ndi madzulo, shuga wanga pamimba yopanda kanthu ali wofanana, ku Levemire madzulo nthawi zonse amakhala okwera pang'ono. Usiku, glycemia nthawi zambiri imakhala yabwino, kusinthasintha kosaposa 0.5, komwe kumayendera. Tsopano kwakhala kosavuta kuti shuga azikhala bwino nthawi yayitali, koma sikuti imagwa kwambiri ngati kale. Kwa mwezi umodzi m'malo ochita masewera olimbitsa thupi kunalibe hypoglycemia imodzi. Chosangalatsa ndichakuti, kuchuluka kwa insulin yayitali kwa ine, ndipo NovoRapid adayenera kuchepetsedwa ndi kotala. Zikuwoneka kuti gawo la ntchito za Levemir lidachitidwa ndi insulin yayifupi, koma sindinkaganiza za izi.Iwunikiridwa ndi Polina, 51. The endocrinologist adandipangira Treshiba monga insulin yabwino kwambiri yomwe ilipo tsopano. Sindinathe kupirira nawo, jekeseni, kupweteka m'thupi, kuyabwa, hypoglycemia ichuluke pafupipafupi, ndipo zotsatira zake ndinabwerera ku Lantus. Inde, ndipo mtengo wa Treshiba sukusangalala, kwa ine ndi okwera mtengo kwambiri.Adatsimikiziridwa ndi Arcadia, wazaka 37. Mwana wamkazi wazaka 10, ali ndi matenda ashuga kuyambira Juni omaliza. Kuyambira pachiyambi pomwe, adasankha Mlingo wa Tresiba ndi Apidra kuchipatala, chifukwa sindingawafananize ndi ma insulini ena. Panalibe zovuta zina ndi Tresiba, khungu lokha linali lokolowedwa poyamba. Choyamba, vutoli lidathetsedwa ndi moisturizer, kenako zovuta sizinathe. Timagwiritsa ntchito Dekskom, ndiye ndili ndi shuga onse m'manja mwanga. Usiku, ndandanda ya glycemic ili pafupi kuzungulira, Tresiba imachita bwino ntchito zake.Chonde dziwani: Kodi mumalota kuti muthetse matenda ashuga kamodzi? Phunzirani momwe mungathetsere matendawa, osagwiritsa ntchito mankhwala okwera mtengo, pogwiritsa ntchito ... >> werengani zambiri apa

Tresiba: malangizo ogwiritsira ntchito, mtengo, ndemanga ndi fanizo

Mwa zina mwazovuta za matendawa, odwala matenda ashuga ambiri amati kulephera kwawo kuchokapo kwa nthawi yayitali kuti asaphonye jakisoni. Pali mankhwala omwe amachotsa vutoli.

"Tresiba" ndi insulin yomwe ingagwiritsidwe ntchito molingana ndi malangizo ogwiritsa ntchito kamodzi patsiku ndipo nthawi yomweyo imamva bwino. Ndipo mutha kutenga cholembera ndi inu ngakhale paulendo.

Ndi maubwino ena ati omwe mankhwalawa ali nawo? Tiyeni tiwone bwinobwino.

Zotsatira za pharmacological

Ili ndi katundu wautali wokhala ndi hypoglycemic. Insulin degludec imapangidwa ndi kubwezeretsanso kwa DNA.

Kamodzi m'thupi, imalumikizana ndi zolandilira za insulin yaumunthu ndikuyamba kuchita ngati gawo la zovuta.

Kugwiritsidwa ntchito kwa glucose ndi minofu ya minofu ndi minyewa yamafuta kumawonjezeka mogwirizana ndi zolandilira zovuta. Zomwe zimachitika mu episode za nocturnal hypoglycemia zimachepetsedwa.

Pharmacokinetics

Kutalika kwa kuchitapo kanthu kupitilira maola 42. Ndi kuyambitsa chinthu kamodzi patsiku, magawidwe ofanana amachitika tsiku lonse. Ma metabolites omwe gawo lomwe limagawika siligwira ntchito. Hafu ya moyo ndi pafupifupi maola 25.

Matenda a shuga m'magulu azaka zonse (kupatula ana osakwana chaka chimodzi).

Bongo

Ndi chitukuko chake, hypoglycemia ikhoza kuchitika. Zizindikiro zazikulu: kufooka, khungu la khungu, kusokonezeka kwa chikumbumtima mpaka kutaya kwake ndi kukula kwa chikomokere, njala, kusokonekera, ndi zina zambiri.

Mitundu yofatsa imathetsedwa mwa iwo okha pakudya chakudya chamafuta ambiri. Hypoglycemia yolimbitsa thupi kwambiri komanso yozama imachotsedwa ndi jakisoni wa shuga kapena dextrose, ndiye kuti muyenera kumuthandiza kuzindikira kuti mudye komanso kumupatsa zakudya zomwe amapatsa zakudya.

Onetsetsani kuti mwakumana ndi dotolo kuti musinthe.

Kuyanjana kwa mankhwala osokoneza bongo

Machitidwe a mankhwala "Tresiba" amathandizidwa ndi:

• njira yolerera ya pakamwa ya mahomoni,
• mahomoni a chithokomiro,
• thiazide okodzeya,
• somatropin,
• GKS,
• amphanomachul
• danazol.

Zotsatira zamankhwala zimatha kufooka:

• mankhwala akumwa a hypoglycemic,
• osasankha beta-blockers,
• GLP-1 zolandila olandila,
• salicylates,
• Mao ndi ACE zoletsa,
• anabolic steroids
• sulfonamides.

Beta-blockers amatha kuphimba zizindikiro za hypoglycemia. Ethanol, komanso "Octreotide" kapena "Lanreotide" amatha kufooka ndikuwonjezera mphamvu ya mankhwalawa.

Malangizo apadera

Kuopsa kwa hypoglycemia kumachulukitsa kulimbitsa thupi, kupsinjika, kudumpha chakudya kapena kubayira mankhwala, matenda ena. Wodwala ayenera kudziwa zomwe akuwonetsa komanso kuti athe kupereka chithandizo choyamba.

Mlingo wosakwanira wa insulin umabweretsa kukula kwa hyperglycemia kapena matenda ashuga ketoacidosis. Muyenera kudziwa zizindikiro zawo ndikupewa kukula kwa zinthu zotere.

Kusinthira ku mtundu wina wa insulin kumayang'aniridwa ndi katswiri. Mungafunike kusintha pazenera.

Matenda a shuga a retinopathy amatha kuchitika kumayambiriro kwa zamankhwala.

"Tresiba" imatha kukopa kuyendetsa galimoto, yomwe imalumikizidwa ndi chitukuko cha hypoglycemia. Chifukwa chake, popewa zinthu zowopsa zomwe zingasokoneze thanzi la wodwalayo ndi ena, funso la kufunika koyendetsa galimoto panthawi ya insulin chithandizo liyenera kuganiziridwa ndi adokotala.

Gwiritsani ntchito muubwana ndi ukalamba

Itha kugwiritsidwa ntchito pochiza ana okulirapo kuposa 1 chaka. Komabe, ziyenera kukumbukiridwa kuti kwa ana mlingo umasankhidwa mosamala, ndipo mkhalidwe wa thupi umayang'aniridwa kwambiri.

Gawani chithandizo kwa okalamba. Nthawi yomweyo, ndikofunikira kudziwa kuti mwa achikulire hypoglycemia imatha kukhazikika mwachangu, chifukwa chake kuyang'anira mkhalidwe waumoyo kumafunika.

Mfundo yogwira ntchito

Insulin ya Tresiba FlexTouch ili ndi mfundo zofananira monga mankhwala a Lantus, odziwika bwino kwa odwala matenda ashuga ambiri. Ma mamolekyulu atalowa m'thupi la munthu, amaphatikizidwa m'magulu akuluakulu, omwe amatchedwanso multicamamera. Amapanga depot ya mankhwala. Komanso, zidutswa zazing'ono zimadulidwamo, zomwe zimapereka mwayi wokhalitsa.

Opanga amati nthawi ya mankhwalawa imaposa maola 40. Malinga ndi kafukufuku wina, amatha kufikira masiku enieni enieni. Pankhaniyi, zitha kuwoneka kuti wothandizirayu amatha kugwiritsidwa ntchito pafupipafupi kuposa insulin yokhazikika. Osati tsiku lililonse, koma kamodzi masiku awiri. Koma kwenikweni izi siziri choncho. Akatswiri amalimbikitsa mwamphamvu kuti musalumphe jakisoni wa tsiku ndi tsiku, kuti musafooketse zotsatira ndi zotsatira zopangidwa ndi mankhwalawa.

Kafukufuku wa "Tresib Insulin" watsopano watsimikizira kuti mankhwalawa ndi othandizanso kwa odwala ndi achinyamata. Panalibe ndemanga zoyipa kuchokera kwa odwala omwe amakhalanso ndi nkhawa ndi zovuta za chiwindi ndi impso.

Chofunikira chachikulu cha "Insulin Tresib" chomwe chakhala nthawi yayitali chinali chothandiza - degludec. Poyerekeza ndi glargine yomwe imagwiritsidwa ntchito ku Lantus, imayambitsa zochitika zochepa za hypoglycemia.

Malangizo ogwiritsira ntchito "Insulin Tresiba" amafotokozera kuchuluka kwa odwala. Mankhwala chikuyendetsedwera subcutaneously, mtsempha wa magazi makonzedwe. Izi zikuyenera kuchitika kamodzi patsiku.

Ndizofunikira kudziwa kuti mankhwalawa amagwirizana ndi mankhwala onse ochepetsa shuga omwe amapezeka pamapiritsi, komanso mitundu ina yambiri ya insulin. Zotsatira zake, imayikidwa padera, ndipo nthawi zina monga gawo la zovuta mankhwala.

Ngati wodwala amapereka insulin poyamba, mlingo uyenera kukhala magawo 10. Kenako zimasinthidwa pang'onopang'ono, zomwe zimatengera zosowa za munthu aliyense.

Wodwala akalandira mtundu wina wa insulin, kenako asankhe kupita ku Treshiba, mlingo woyambirira amawerengedwa molingana ndi umodzi. Izi zikutanthauza kuti insulini dehydlude iyenera kuthandizidwa ndendende monga momwe insal insulin idaperekedwera.

Ngati wodwalayo kwakanthawi anali wopezeka insulin, ndiye kuti dokotalayo ayenera kutsimikiza ndi dokotala aliyense payekha. Zingakhale kuti zitha kuchepa. Zomwezi zimawonedwa ngati mulingo wa glycated hemoglobin wodwala umakhala wochepera 8%.

Zachidziwikire, mtsogolomo, wodwalayo adzafunikira kusintha kwamankhwala ochepa mothandizidwa ndi shuga omwe ali m'magazi.

Zizindikiro ndi contraindication

Malangizo "Tresiba Insulin" mosakayikira amalimbikitsa kugwiritsa ntchito mankhwalawa pochiza odwala matenda ashuga.

Pankhaniyi, mankhwalawa amatsutsana m'magulu otsatirawa a odwala:

• ana ndi achinyamata ochepera zaka 18,
• azimayi oyembekezera
• amayi oyamwitsa
• odwala omwe ali ndi vuto laumwini ku chinthu chachikulu cha mankhwala kapena zilizonse zothandiza.

Mankhwala amapezeka mu mawonekedwe a yankho la subcutaneous makonzedwe. Chofunikira chachikulu ndi insulin degludec.

Phenol, glycerol, zinc, hydrochloric acid, komanso madzi ofunikira jakisoni amagwiritsidwa ntchito ngati zinthu zothandiza mu mankhwalawa.

Phukusi limodzi, ma syringe asanu okhala ndi 3 ml ya chinthu chilichonse.

Insulin degludec imatha kumangiriza makamaka ku cholandilira cha insulin. Molumikizana naye mwachindunji, amazindikira mtundu wake wa mankhwala, womwe uli wofanana ndi zochita za insulin ya munthu.

Ndizofunikira kudziwa kuti katundu wa hypoglycemic wa mankhwalawa chifukwa chitha kuwonjezera kwambiri kugwiritsa ntchito shuga. Izi zimachitika chifukwa chomangiriza insulini yokha ku ma cell a mafuta ndi minofu. Ndikofunikira kuti poyerekeza ndi izi, kuchuluka kwa shuga m'chiwindi kumachepetsedwa kwambiri.

Ndemanga za Odwala

Ndemanga za anthu odwala matenda ashuga okamba za Insulin ya Tresib nthawi zambiri amathanso kukumana mwachangu. Jekeseni nthawi zambiri amachitika usiku. Izi zimapangitsa kuti munthu amene ali ndi shuga wabwinobwino adzuke m'mawa ali bwinobwino.

Chachikulu ndikuti mankhwalawa amasankhidwa molondola. Pakuwunika kwa anthu odwala matenda ashuga omwe adakumana ndi "Insulin Tresiba" zidadziwika kuti mitundu iyi isanawonekere, mitundu yonse yam'mbuyomu idasinthiratu nthawi, zomwe zidabweretsa zovuta zambiri. Kusala glucose kunali kovuta kwambiri.

Nthawi yomweyo, ambiri m'mawunikidwe ndi Insulin Tresibe agogomezera kuti mwayi wofunikira wa mankhwalawo wagona chifukwa ndi chithandizo chake ndizotheka kuchepetsa bwino magazi poyerekeza ndi njira zina zambiri zofananira. Mwachitsanzo, ndi "Lantus" kapena "Levemire." Kuphatikiza apo, chiopsezo chokhala ndi hypoglycemia chimachepetsedwa kwambiri, komabe chimakhalabe chifukwa cha bongo. Izi zimadziwika mu malingaliro ndi malangizo ogwiritsira ntchito Insulin Tresib.

Ndi malingaliro abwino onse, ndikofunikira kudziwa kuti malingaliro olakwika okhudzana ndi mankhwalawa akupezekabe. Zowona, kuwerengetsa kosalimbikitsa pa Tresib's Insulin sikugwirizana ndi kugwira kwake, koma ndi mtengo wokwera.

Dziwani kuti odwala olemera okha ndi omwe angakwanitse kugula izi, chifukwa mankhwalawa ndi okwera mtengo kwambiri kuposa ma analogu ena ambiri. Ngati muli ndi ndalama zaulerezi, muyenera kukambirana za kusintha kwa insulin yatsopano ndi dokotala. Tikugogomezera kuti ndi matenda ashuga, mankhwala ambiri amaikidwa payekha, kutengera mtundu wa wodwalayo. Kuphatikiza apo, ndikofunikira kudziwa mlingo woyenera malinga ndi thanzi la wodwala wina.

Dziwani kuti Insulin Tresiba pakadali pano imakhala yokwera mtengo pafupifupi katatu kuposa Levemir ndi Lantus, yomwe imagwiritsidwanso ntchito kwambiri mu shuga ndi odwala ambiri.

Akatswiri omwe ali pafupi ndi bizinesi yamankhwala kuti m'zaka zikubwerazi titha kudalira mawonekedwe a analogues, omwe katundu wawo sangakhale wosangalatsa kuposa wa Insulin Tresib. Muyenera kuwerenga malingaliro ndi malangizo a mankhwalawa mosamala, koma simuyenera kudalira mankhwalawa kuti akhale otsika mtengo. Izi zimachitika makamaka chifukwa pakadali pano pali makampani ochepa odziwika padziko lapansi omwe akuchita nawo ntchito yopanga insulin yamakono komanso yapamwamba kwambiri. Nthawi yomweyo, pali lingaliro kuti pali mgwirizano wamakampani pakati pawo womwe umalola kuti mitengo isasinthidwe pamalo olimba.

Fananizani ndi fanizo

Insulin yamtunduwu imakhala ndi mitundu yambiri. Ndikulimbikitsidwa kuti muzidziwika bwino kuti mufananitse katundu.

Ndemanga zambiri za anthu odwala matenda ashuga omwe akudziwa za mankhwalawa ndi zabwino. Kutalika kwa ntchitoyo, kusakhalapo kwa zotsatira zoyipa kapena kakulidwe kake kodziwika. Mankhwalawa ndi oyenera kwa odwala ambiri. Pakati pa mphindi pali mtengo wokwera.

Oksana: “Ndakhala ndili pa insulin kuyambira ndili ndi zaka 15. Ndayesa mankhwala ambiri, tsopano ndayimitsidwa ku Tresib. Yosavuta kugwiritsa ntchito, ngakhale okwera mtengo. Ndimakonda kutalika kotero, palibe magawo a usiku a hypo, ndipo izi zisanachitike. Ndakhuta. "

Sergey: "Posachedwa ndinasinthira kulandira mankhwala a insulin - mapiritsiwo anasiya kuthandiza. Dotolo adalangiza kuyesa cholembera cha Tresiba.

Ndinganene kuti ndikosavuta kudzipatsa jakisoni, ngakhale ndiyatsopano pamenepa. Mlingo wawonetsedwa pachiwonetsero ndi chizindikiro, chifukwa chake simulakwitsa kudziwa kuchuluka komwe muyenera kulowa. Shuga limakhala losalala komanso lalitali.

Palibe zotsatira zoyipa zomwe zimakondweretsa mapiritsi ena ake. Mankhwalawa amandigwira ndipo ndimaukonda. ”

Diana: “Agogo amadwala matenda a shuga omwe amadalira insulin. Ndinkakonda kubaya jakisoni, chifukwa iyenso amawopa. Dotolo adandiwuza kuti ndiyesere Tresibu. Tsopano agogo omwewo amatha kupanga jakisoni. Ndizotheka kuti kamodzi patsiku muyenera kuchita, ndipo zotsatira zake zimakhala kwa nthawi yayitali. Ndipo thanzi langa layamba bwino. ”

Denis: "Ndili ndi matenda a shuga a 2, ndiyenera kugwiritsa ntchito insulin kale. Adakhala nthawi yayitali pa "Levemire", adasiya kugwira shuga. Adotolo adasamukira ku Tresibu, ndipo ndidalandira. Njira yothandiza kwambiri, shuga sangakhale yovomerezeka, palibe chomwe chimapweteka. Ndinafunika kusintha zakudya zochepa, koma ndibwinonso - kulemera sikumakukula. Ndimakondwera ndi mankhwalawa. ”

Alina: “Mwana atabadwa, anapeza matenda a shuga a 2. Ndibaya insulin, ndidaganiza zoyesera ndi chilolezo cha dokotala wa Treshibu. Zilandira pazabwino, ndiye kuti palinso. Ndimakonda kuti zotsatira zake ndizitali komanso ndizokhalitsa. Kumayambiriro kwa mankhwalawa, retinopathy adapezeka, koma mlingo udasinthidwa, zakudya zidasinthidwa pang'ono, ndipo zonse zidali mu dongosolo. Kuchiritsa kwabwino. ”

Gulu la Nosological (ICD-10)

Zoyenera kufalitsa kuchokera kuma fakitoli:

Mayendedwe ogwiritsa ntchito

Cartridge ya Penfill ® idapangidwa kuti igwiritsidwe ntchito ndi makina a jekeseni a Novo Nordisk insulin ndi singano za NovoFine ® kapena NovoTvist ® mpaka 8 mm.

Tresiba ® Penfill ® ndi singano ndizongogwiritsa ntchito nokha. Kudzazidwa kwa cartridge sikuloledwa.

Simungagwiritse ntchito mankhwalawa ngati yankho laleka kukhala lowonekera komanso lopanda utoto.

Simungagwiritse ntchito mankhwalawa ngati adazizira.

Ponyani singano pambuyo pa jekeseni iliyonse. Onani malamulo am'deralo okhudzana ndi kugwiritsidwa ntchito kwa zinthu zogwiritsidwa ntchito ngati mankhwala.

Malangizo atsatanetsatane ogwiritsira ntchito - onani malangizo.

Kapangidwe ndi mawonekedwe a kumasulidwa kwa Tresib

The yogwira pophika mankhwala Tresib ndi recombinant anthu insulin degludec. Insulin imapezeka monga njira yopanda utoto yoyendetsera khungu. Mitundu iwiri yomasulidwa alembedwa:

1. Mlingo wa 100 PIECES / ml: insulin degludec 3.66 mg, cholembera cha syringe ndi 3 ml ya yankho. Mumakulolani kuti muyike mpaka magawo 80 pazowonjezera za 1 unit. Mu phukusi 5 zolembera FlexTouch.
2. Mlingo wa 200 PESCES pa 1 ml: insulin degludec 7.32 mg, 3 ml syringe cholembera, mutha kulowa mu PIECES mu 160 mu 2 PIECES. Mu phukusi pali zolembera 3 FlexTouch.

Cholembera cha kuyambitsa insulini ndichotheka kutulutsa majakisoni mobwerezabwereza.

Katundu wa Treshiba Insulin

Insulin yatsopano yochita zinthu zambiri yokhala ndi malo okhala ndi malo okhala mapangidwe azinthu zosungunuka zamagetsi. Pang'onopang'ono gululi limatulutsa insulini kulowa m'magazi. Chifukwa cha kukhalapo kosalekeza m'magazi, kuchuluka kwa glucose m'magazi kumatsimikiziridwa.

Ubwino wawukulu wa Tresib ndi mbiri komanso yosabisa ya zochita za hypoglycemic. Mankhwalawa m'masiku ochepa amafika paphiri la glucose ndikuwusunga nthawi yonse yogwiritsira ntchito, ngati wodwalayo sakuphwanya malamulo othandizira ndikutsatira kuchuluka kwa insulin ndikutsatira malamulo a zakudya.

Kuchita kwa Tresib pamlingo wamagazi m'magazi kumaonekera chifukwa chogwiritsa ntchito glucose ndi minofu ndi minyewa ya adipose monga gwero lamphamvu mkati mwa khungu. Tresiba, yolumikizana ndi insulin receptors, imathandiza shuga kuthana ndi nembanemba ya cell. Kuphatikiza apo, imathandizira kupanga kwa glycogen kupanga chiwindi ndi minofu minofu.

Mphamvu ya Tresib pa metabolism imawonekera chifukwa chakuti:

1. Palibe mamolekyu atsopano a shuga omwe amapangidwa m'chiwindi.
2. Kuwonongeka kwa glycogen m'misika m'maselo a chiwindi kumachepetsedwa.
3. Mafuta acids amapangidwa, ndipo kusweka kwamafuta kumayima.
4. Mlingo wa lipoproteins m'magazi ukuwonjezeka.
5. Minofu kukula.
6. Kupanga kwa mapuloteni kumalimbikitsidwa ndikuwonongeka kwake nthawi yomweyo kumachepetsedwa.

Tresiba FlexTouch insulin imateteza ku ma spikes a shuga masana pambuyo pa kukhazikitsa. Kutalika konse kwa kuchitapo kwake kupitirira maola 42. Kuphatikizika kosalekeza kumatheka mkati mwa masiku awiri kapena atatu pambuyo pa jekeseni woyamba.

Ubwino wachiwiri wosakayikira wa mankhwalawa ndi kusakhazikika kwachilendo kwa hypoglycemia, kuphatikiza usiku, poyerekeza kukonzekera kwina kwa insulin. Mu phunziroli, njira yotereyi idadziwika mu onse achinyamata ndi okalamba odwala.

Umboni wa odwala omwe adagwiritsa ntchito mankhwalawa amatsimikizira chitetezo chake chogwiritsidwa ntchito pokhudzana ndi kuchepa kwambiri kwa shuga ndi matenda a hypoglycemia. Maphunziro oyerekeza a Lantus ndi Tresib awonetsa kuyeserera kwawo kofanana pakukonda kuzungulira kwa insulin.

Koma kugwiritsa ntchito mankhwalawa kuli ndi zabwino zake, chifukwa n`zotheka kuchepetsa kuchuluka kwa insulini pakapita nthawi 20-30% ndikuchepetsa kwambiri kuchuluka kwa odwala usiku.

Tresiba imathandizira pamlingo wa hemoglobin wa glycated, zomwe zikutanthauza kuti zimachepetsa chiopsezo cha zovuta za shuga.

Kodi Treshiba akuwonetsedwa kwa ndani?

Chizindikiro chachikulu cha mankhwala a Treshib insulin, omwe amatha kukhalabe ndi gawo la glycemia, ndi matenda a shuga.

Contraindication yogwiritsira ntchito mankhwalawa ndikumvetsetsa kwamunthu payekha pazigawo za yankho kapena chinthu chogwira ntchito. Komanso, chifukwa cha kusadziwa za mankhwalawa, samalembera ana ochepera zaka 18, amayi oyamwitsa ndi amayi apakati.

Ngakhale kuti nthawi ya insulin excretion ndi yayitali kuposa masiku 1.5, tikulimbikitsidwa kuti mulowetsedwe kamodzi patsiku, makamaka nthawi imodzi. Wodwala matenda a shuga amtundu wachiwiri amatha kulandira Tresib kapena kuphatikiza ndi mankhwala ochepetsa shuga m'mapiritsi. Malinga ndi zomwe zikuwonetsa mtundu wachiwiri wa matenda ashuga, ma insulin omwe amagwira ntchito mwachidule amalembedwera limodzi ndi mankhwalawo.

Mtundu woyamba wa matenda ashuga, Trecib FlexTouch nthawi zonse umakhazikitsidwa ndi insulin yochepa kapena yochepa kwambiri kuti athe kufunikira kwa kumumizira kwa chakudya.

Mlingo wa insulin umatsimikiziridwa ndi chithunzi cha matenda osokoneza bongo ndipo umasinthidwa malinga ndi kuchuluka kwa shuga m'magazi.

Kukhazikitsidwa kwa mtundu watsopano wa Tresib kumachitika:

• Mukamasintha zolimbitsa thupi.
• Mukasinthana ndi chakudya china.
• Ndi matenda opatsirana.
• Kuphwanya ntchito ya endocrine dongosolo - matenda a chithokomiro England, pituitary gland kapena adrenal gland.

Tresiba imatha kuperekedwa kwa odwala okalamba omwe ali ndi vuto la impso kapena chiwindi, malinga ngati kuchuluka kwa shuga m'magazi kumayang'aniridwa mosamala.

Kwa odwala omwe ali ndi matenda a shuga a 2, amayamba ndi mlingo wa 10 PESCES, kusankha payekha. Odwala omwe ali ndi mtundu woyamba wa matenda, mukamasinthira ku Treshiba kuchokera ku ma insulin ena omwe amakhala nthawi yayitali, gwiritsani ntchito mfundo ya "kusintha gawo mwa unit".

Ngati wodwala alandira jakisoni wa basal insulin maulendo awiri, ndiye kuti kusankha kwa mankhwalawa kumachitika pamaziko a mbiri ya glycemic payekha. Tresiba imalola kupatuka munjira yoyendetsera, koma nthawiyo imalimbikitsidwa kwa maola osachepera 8.

Mlingo womwe wasowa ungathe kulowetsedwa nthawi iliyonse, tsiku lotsatira mutha kubwerera ku chiwembu chapitacho.

Malamulo ogwiritsira ntchito Treshiba FlexTouch

Tresib imayendetsedwa kokha pakhungu. Mtsempha wamkati umapangidwa chifukwa cha kukula kwa hypoglycemia. Sizikulimbikitsidwa kuti ziperekedwe intramuscularly komanso mapampu a insulin.

Malo omwe insulin amayendetsedwera ndi kutsogolo kwa ntchafu, phewa, kapena khoma lamkati lakumbuyo. Mutha kugwiritsa ntchito gawo limodzi labwino kwambiri, koma nthawi iliyonse kumayambitsa malo atsopano kupewa lipodystrophy.

Kupereka insulin pogwiritsa ntchito cholembera cha FlexTouch, muyenera kutsatira njira zotsata:

1. Onani cholembera
2. Onetsetsani kuwonekera kwa yankho la insulin
3. Ikani singano mwamphamvu pachikuto
4. Yembekezani mpaka dontho la insulini lithe pa singano
5. Khazikitsani mlingo potembenitsira mtundu wosankha
6. Ikani singano pansi pa khungu kuti mankhwala otsutsana nawo awoneke.
7. Dinani batani loyambira.
8. Lowetsani insulin.

Pambuyo pa jakisoni, singano iyenera kukhala pansi pa khungu kwa masekondi 6 ena kudya kwathunthu kwa insulin. Kenako chogwiriziracho chimayenera kukwezedwa. Ngati magazi awonekera pakhungu, ndiye kuti amayimitsidwa ndi swab thonje.Musamasewetse malo a jakisoni.

Zingwe ziyenera kuchitika pokha kugwiritsa ntchito zolembera pazokha. Kuti muchite izi, khungu ndi manja asana jekeseni ayenera kuthandizidwa ndimayendedwe a antiseptics.

Cholembera cha FlexTouch sichiyenera kusungidwa pamtunda wambiri kapena wotsika kwambiri. Asanatsegule, mankhwalawa amasungidwa mufiriji pakashelefu apakati pamtunda wa madigiri 2 mpaka 8. Osamayimitsa yankho. Pambuyo pakugwiritsira ntchito koyamba, cholembera chimasungidwa kutentha kwa chipinda osapitilira milungu 8.

Osasamba kapena kudzoza mafuta chogwirizira. Iyenera kutetezedwa kuti isavunditsidwe ndikutsukidwa ndi nsalu yonyowa. Kugwa ndi maampu sikuyenera kuloledwa. Mukatha kugwiritsa ntchito kwathunthu, cholembera sichidzazidzanso. Simungathe kukonza kapena kudzipatula nokha.

Pofuna kupewa kutsata molakwika, muyenera kusungira ma insulini osiyanasiyana payokha, ndikuyang'anitsitsa chizindikiro asanakugwiritse ntchito kuti musapange jakisoni wina mwangozi. Muyeneranso kuwona bwino manambala pa kotsutsa. Ndi mawonekedwe opuwala, muyenera kugwiritsa ntchito thandizo la anthu omwe ali ndi maso abwino komanso ophunzitsidwa poyambitsa Tresib FlexTouch.

Pomaliza

Tresiba ndi mankhwala abwino pochiza matenda onse a shuga. Imakwanira odwala matenda ashuga ambiri, itha kupezekanso ndi phindu. Madokotala amayamika mankhwalawa chifukwa chogwira ntchito mosamalitsa komanso nthawi yayitali, kuchititsa kuti odwala azikhala ndi moyo wathanzi popanda kuwononga thanzi. Chifukwa chake mankhwalawa ndioyenera kukhala ndi mbiri yabwino.

Mankhwala

Mankhwala Tresiba ® FlexTouch ® ndi chithunzi cha insulin ya anthu yowonjezera nthawi yayitali, yopangidwa ndi njira yobwereza sayansi ya biology pogwiritsa ntchito kupopera Saccharomyces cerevisiae.

Njira yamachitidwe. Insulin degludec imamangiriza makamaka ku cholandilira cha insulin ya insulin ya anthu ndipo, ikulumikizana nayo, imazindikira mphamvu yake ya pharmacological yofanana ndi mphamvu ya insulin yaumunthu.

Mphamvu ya hypoglycemic ya degludec insulin imayamba chifukwa cha kugwiritsidwa ntchito kwa glucose pogwiritsa ntchito minofu pambuyo pomangiriza insulin kutikita minofu ndi ma cell cell receptors komanso kuchepa kwa munthawi yomweyo.

The Tresiba ® FlexTouch ® ndi analogue ya insulin ya anthu yoposa kanthu, pambuyo pa s / c jekeseni imasungunuka kosakanikirana kosiyanasiyana mu malo osungirako, komwe kumayamwa insuludec insulin nthawi zonse pabedi lamitsempha, kumapereka mawonekedwe osasunthika okhudzana ndi vuto la hypoglyc. onani Chithunzi 1).

Munthawi ya kuwunika kwa maola 24 a hypoglycemic zotsatira za mankhwala mwa odwala omwe mankhwalawa a degludec insulin adalandira kamodzi patsiku, Tresiba ® FlexTouch ®, mosiyana ndi insulin glargine, adaonetsa yunifolomu V_d pakati pa zochita nthawi yoyamba ndi yachiwiri ya maola 12 (AUC_{GIR0-12h, SS}/ Auc_{GIRtotal, SS} =0,5).

Chithunzi 1. Chithunzi cha ma 24 maola a glucose kulowetsedwa kwa mbiri - C_ss insulin degludec 100 U / ml 0,6 U / kg (1987 kafukufuku)

Kutalika kwa nthawi ya mankhwalawa Tresiba ® FlexTouch ® ndi maola opitilira 42 kuchokera munthawi yamankhwala othandizira. C_ss The mankhwala plasma magazi zimatheka patatha masiku 2-3 pambuyo mankhwala.

Insulin degludec mu boma C_ss amawonetsa kuchepa kwambiri (nthawi 4) poyerekeza ndi insulin glargin tsiku ndi tsiku zosinthika za hypoglycemic kanthu, zomwe zimayesedwa ndi phindu la kuchuluka kwa kusiyanasiyana (CV) pakuwunika kwa zotsatira za hypoglycemic ya mankhwala munthawi imodzi ya dosing (AUC_{GIR.aling, SS}) komanso mkati mwa nthawi kuchokera 2 mpaka maola 24 (AUC_{GIR2-24h, SS}), (onani Gawo 1.)

Kusintha kwatsiku ndi tsiku kwa hypoglycemic ya mankhwala a Tresiba ndi insulin glargine mu boma C_ss odwala matenda a shuga 1

CV: mgwirizano wokwanira pakati pamunthu,%.

b SS: Kuzungulira kwa mankhwalawa mogwirizana.

c AUC_{GIR2-24h, SS}: metabolic zotsatira mu maola 22 omaliza a nthawi ya dosing (i.e. palibe zotsatira pa izo ya jekeseni iv insulin panthawi yoyambitsa kuphunzira kwa clamp).

Ubale wolimba pakati pakuwonjezereka kwa mlingo wa Tresiba ® FlexTouch ® ndi zotsatira zake zazikulu za hypoglycemic zatsimikiziridwa.

Maphunzirowa sanawonetse kusiyana kwakukulu mu pharmacodynamics ya mankhwala a Tresiba ® mwa odwala okalamba komanso odwala achinyamata.

Kuchita Mwachipatala ndi Chitetezo

Mayeso azachipatala adawonetsa kuchepa komweko ku HbA_1c kuchokera ku mtengo woyambira kumapeto kwa kafukufukuyo kumbuyo kwa mankhwala omwe ali ndi insulin Tciousba ® ndi insulin glargine 100 IU / ml. Odwala omwe ali ndi matenda a shuga 1 a mtundu wa mellitus (T1DM) omwe amathandizidwa ndi Tresib ® insulin mankhwala amawonetsa kuchepa kwakukulu kwa hypoglycemia komanso kwambiri kapena kutsimikizika kwa hypoglycemia (hypoglycemia yonse ndi nocturnal hypoglycemia poyerekeza ndi insulin glargine 100 IU / ml, monga nthawi ya insulin kukhala ndi mlingo, komanso munthawi yonse ya chithandizo. Odwala omwe ali ndi mtundu wa 2 shuga mellitus (T2DM) omwe amathandizidwa ndi Tresib ® insulin mankhwala adawonetsa kuchepa kwakukulu kwa chovuta kwambiri kapena chotsimikizika cha hypoglycemia (chonse cha hypoglycemia ndi nocturnal hypoglycemia) poyerekeza ndi insulin glargine (100 IU / ml), monga nthawi yokonza Mlingo, komanso nthawi yonse ya chithandizo, komanso kuchepa kwa zochitika za hypoglycemia nthawi yonse yamankhwala.

M'maphunziro azachipatala, kuchepa kwa kuphatikiza kwa mankhwala oyerekeza (insulin detemir ndi insulin glargine) pa Tresiba ® pokhudzana ndi kuchepa kwa HbA_1c kuyambira poyambira kumapeto kwa kafukufuku. Kupatula kwake kunali sitagliptin, pomwe Tresiba ® adawonetsa ukulu wake pokweza HbA_1c.

Zotsatira za kusanthula kwa meta kuchokera ku maphunziro asanu ndi awiri kunawonetsa maubwino a Tresib ® insulin Therapy ndi kuchepa kwapakati kwa hypoglycemia yotsimikizika mwa odwala poyerekeza ndi glargine insulin Therapy (100 U / ml) (Gome 2) ndikutsimikizira zochitika za nocturnal hypoglycemia. Kuchepa kwa pafupipafupi kwa ma episode a hypoglycemia nthawi ya Tresib ® insulin Therapy kumatheka ndi glucose yotsika pang'ono poyerekeza ndi insulin glargine (100 IU / ml).

Zotsatira za kusanthula kwa meta pazosintha za hypoglycemia

a Hypoglycemia Yotsimikizika ndi gawo la hypoglycemia yotsimikiziridwa ndi kuyeza plasma glucose concentration b Episode of hypoglycemia pambuyo pa sabata la 16 la mankhwala.

c Cofunika kwambiri.

Palibe kupangika kwofunikira kwambiri kwa ma antibodies kwa insulin komwe kunapezeka pambuyo pa chithandizo cha Tresib ® kwa nthawi yayitali. Pakufufuza kwamankhwala kwa odwala omwe ali ndi T2DM omwe amathandizidwa ndi Tresiba® kuphatikiza ndi metformin, kuwonjezera kwa liraglutide kunapangitsa kutsika kwakukulu kwa HbA_1s ndi kulemera kwa thupi. Chiwopsezo cha hypoglycemia chinali chotsika kwambiri ndi kuphatikiza kwa liraglutide poyerekeza ndi kuphatikiza kwa mlingo umodzi wa insulin.

Kuunikira momwe CCC ikukhudzira. Kuyerekeza chitetezo chamtima pogwiritsira ntchito mankhwalawa Tresiba ndi insulin glargine (100 PIECES / ml), kafukufuku adachitika DEVOTE kuphatikiza odwala 7837 omwe ali ndi T2DM komanso chiopsezo chachikulu chokhala ndi zochitika za mtima.

Chitetezo pamtima cha kugwiritsa ntchito mankhwala a Tresiba® poyerekeza ndi insulin glargine chatsimikiziridwa (Chithunzi 2).

N Chiwerengero cha odwala omwe ali ndi chochitika choyamba chotsimikiziridwa ndi Expert Advisory Panel on the Assessment of Undesential Events (EAC) pa phunziroli.

% Gawo la odwala omwe ali ndi vuto loyamba lomwe limatsimikiziridwa ndi EAC, mogwirizana ndi kuchuluka kwa odwala omwe adasankhidwa.

Chithunzi 2: Chithunzi chithunzi cha nkhalango chosonyeza kuwunika kwa mitu itatu ya chitetezo chamtundu wa zochitika za mtima (CVSS) komanso malekezero a mtima mu kafukufuku. DEVOTE.

Pogwiritsa ntchito insulin glargine komanso mankhwala a Tresiba ®, kusintha kofananako kwa milingo ya HbA kunakwaniritsidwa_1s ndi kuchepa kwakukulu kwa shuga m'magazi a plasma mukamagwiritsa ntchito mankhwala a Tresiba ® (tebulo 3).

Tresiba ® adawonetsa mwayi wa insulin glargine malinga ndi kuchepa kwakukulu kwa hypoglycemia komanso gawo lotsika la odwala omwe adayamba kudwala kwambiri hypoglycemia. Pafupipafupi ma episode a nocturnal hypoglycemia anali otsika kwambiri pogwiritsa ntchito Tresiba ® poyerekeza ndi insulin glargine (Table 3).

Zotsatira zakufufuza DEVOTE

Mtengo wapakati wa HbA_1s, %

Hypoglycemia pafupipafupi (mwa zaka 100 za kupenyerera)

Champhamvu hypoglycemia

Makamaka usiku hypoglycemia 2

Chiwopsezo chapafupi: 0.47 (0.31, 0.73)

Chiwerengero cha odwala omwe amapanga magawo a hypoglycemia (% ya odwala)

Champhamvu hypoglycemia

Chiwopsezo cha Odds: 0.73 (0.6, 0.89)

1 Kuphatikiza muyeso wothandizira matenda ashuga ndi mtima.

2 Usiku kwambiri hypoglycemia ndi hypoglycemia yomwe idachitika nthawi yausiku pakati pa 0 ndi 6 am.

Ana ndi achinyamata. Pakufufuza kwamankhwala mu ana ndi achinyamata omwe ali ndi matenda a shuga 1, kugwiritsa ntchito Tresiba ® kamodzi patsiku kunawonetsa kuchepa komweko kwa HbA_1s Pofika sabata la 52 ndikuchepa kwambiri kwa shuga m'magazi a shuga m'magazi oyambira poyerekeza ndi kugwiritsa ntchito mankhwala oyerekeza 1 (2 insulin) kawiri patsiku. Izi zimatheka pogwiritsa ntchito mankhwala a Tresiba tsiku lililonse 30% yotsika poyerekeza ndi insulin. The pafupipafupi (phenomena pa wodwalayo pachaka kukhudzana) za episode kwambiri hypoglycemia (tanthauzo la International Society for the Study of Diabetes Mellitus (DM) mwa ana ndi achinyamata (ISPAD), 0.51 poyerekeza ndi 0.33), idatsimikizira hypoglycemia (57.71 poyerekeza ndi 54.05) ndikutsimikizira hypoglycemia usiku (6.03 poyerekeza ndi 7.6) ikufanana ndi Tresiba ® komanso insulin . M'magulu onse awiri azachipatala mwa ana a zaka 6 mpaka 11, kuchuluka kwa matenda a hypoglycemia kunali kwakukulu kuposa m'mibadwo ina. Panali chiwopsezo chachikulu cha hypoglycemia mwa ana azaka 6 mpaka 11 pagulu la Tresiba ®. Pafupipafupi ma episode a hyperglycemia okhala ndi ketosis anali otsika kwambiri ndi kugwiritsa ntchito mankhwalawa Tresiba poyerekeza ndi mankhwalawa ndi insulin, 0.68 ndi 1.09, motsatana. Kukula kwamtundu, mtundu ndi kuopsa kwa mayendedwe obwera chifukwa cha kuchuluka kwa odwala omwe ali ndi odwala sikusiyana ndi kuchuluka kwa odwala omwe ali ndi matenda ashuga.Kupanga kwa antibody kunali kosowa ndipo kunalibe tanthauzo la kliniki. Zambiri zokhudzana ndi chitetezo komanso chitetezo kwa achinyamata omwe ali ndi T2DM adachotsedwa pochokera pazomwe zidapezedwa kwa achinyamata ndi odwala akuluakulu omwe ali ndi T1DM komanso odwala akulu omwe ali ndi T2DM. Zotsatira zake zimatithandizanso kuti tivomereze mankhwala a Tresiba ® pochiza achinyamata omwe ali ndi matenda a shuga a 2.

Contraindication

kuchuluka kwa chidwi cha munthu pantchito kapena chilichonse chothandizira cha mankhwala,

nthawi ya pakati, nthawi yakamayi

ana a zaka mpaka 1 chaka chiyambire mayesero azachipatala mwa ana osaposa chaka chimodzi sanachitike.

Mimba komanso kuyamwa

Kugwiritsa ntchito kwa mankhwala a Tresiba ® FlexTouch ® pa nthawi ya pakati kumatsutsana, chifukwa Palibe chokuchitikira kuchipatala ndi momwe amagwiritsidwira ntchito panthawi yomwe ali ndi pakati. Kafukufuku wokhudzana ndi kubereka mu nyama sikunawonetse kusiyana pakati pa insludec insulin ndi insulin yaumunthu molingana ndi embryotoxicity ndi teratogenicity.

Kugwiritsa ntchito kwa mankhwala a Tresiba ® FlexTouch ® nthawi yoyamwitsa kumatsutsana, chifukwa palibe zochitika zamankhwala ndi akazi opaka mkaka.

Kafukufuku wazinyama adawonetsa kuti mu makoswe, degludec insulin imachotsedwa mkaka wa m'mawere, ndipo kuchuluka kwa mankhwala mkaka wa m'mawere kumatsika kuposa plasma yamagazi.

Sizikudziwika ngati insulin degludec imachotsedwa mkaka wa amayi.

Kuwoneka kwa zotsatira za metabolic mwa ana akhanda ndi makanda oyamwitsa sikuyembekezeredwa.

Kuchita

Pali mankhwala angapo omwe amakhudza kagayidwe ka glucose.

Kufunika kwa insulini kungachepe: PHGP, GLP-1 receptor agonists, Mao inhibitors, osasankha beta-blockers, zoletsa za ACE, salicylates, anabolic steroids ndi sulfonamides.

Kufunika kwa insulin kungakulitse: njira yolerera ya pakamwa ya mahomoni, thiazide diuretics, corticosteroids, mahomoni a chithokomiro, sympathomimetics, somatropin ndi danazole.

Beta blockers imatha kuvala zizindikiro za hypoglycemia.

Octreotide / Lanreotide ikhoza kuwonjezera ndikuchepetsa kufunika kwa insulin.

Ethanoli (mowa) ikhoza kuwongolera ndikuchepetsa mphamvu ya insulin.

Kusagwirizana. Zinthu zina zamankhwala, zikaonjezeredwa ku Tresib ® FlexTouch ®, zimatha kuwononga. Mankhwala Tresiba ® FlexTouch ® sangathe kuwonjezera mayankho a kulowetsedwa. Simungasakanikize mankhwala a Tresiba ® FlexTouch ® ndi mankhwala ena.

Malangizo kwa wodwala

Muyenera kuwerenga malangizo awa musanagwiritse ntchito cholembera cha Tresib ® FlexTouch ®. Ngati wodwalayo samatsata malangizowo mosamala, amatha kupereka insulin yokwanira kapena yayikulu kwambiri, yomwe ingayambitse kuchuluka kwambiri kwa shuga m'magazi.

Gwiritsani ntchito cholembera pokhapokha wodwala atatha kugwiritsa ntchito motsogozedwa ndi dokotala kapena namwino.

Muyenera kudziwa kaye zomwe zalembedwa pa cholembera cha syringe kuti zitsimikizire kuti ili ndi Tresiba ® FlexTouch ® 100 PIECES / ml / Tresiba ® FlexTouch ® 200 PIECES / ml, kenako phunzirani mosamala zithunzi zomwe zikuwoneka, zomwe zikuwonetsa tsatanetsatane wa cholembera ndi singano.

Ngati wodwala ali ndi vuto la khungu kapena ali ndi vuto lalikulu lakuwona ndipo sangathe kusiyanitsa pakati pa manambala omwe akukwaniritsidwa, musagwiritse ntchito cholembera popanda thandizo. Wodwala chotere amatha kuthandizidwa ndi munthu popanda kuwonongeka kwa mawonekedwe, wophunzitsidwa bwino moyenera cholembera cha FlexTouch ®.

Tresiba ® FlexTouch ® 100 U / ml - cholembera chodzaza ndi syringe chokhala ndi 300 PISCES ya insulin degludec. Mlingo wapamwamba kwambiri womwe wodwalayo angathe kukhazikitsa ndi magawo 80 pazowonjezera za 1 unit.

Tresiba ® FlexTouch ® 200 UNITS / ml - cholembera chodzaza ndi syringe chisanakhale ndi 600 PISCES ya insulin degludec. Mlingo waukulu womwe wodwalayo angathe kukhazikitsa ndi mayunitsi 160 mu zowonjezera za 2 mayunitsi.

Khola la syringe lakonzedwa kuti lizigwiritsidwa ntchito ndi singano zotayika NovoFayn ® kapena NovoTvist ® mpaka 8 mm kutalika. Zingano sizikuphatikizidwa mu phukusi.

Chidziwitso Chofunikira. Samalani zidziwitso zolemba chofunikira, ndikofunikira kwambiri pakugwiritsa ntchito cholembera.

Chithunzi 3. Tresiba ® FlexTouch ® 100 U / ml.

Chithunzi 4. Tresiba ® FlexTouch ® 200 U / ml.

I. Kukonzekera cholembera kuti mugwiritse ntchito

Chongani dzina ndi Mlingo pa zilembo za cholembera kuti muonetsetse kuti ili ndi Tresiba ® FlexTouch ® 100 IU / ml / Tresiba ® FlexTouch ® 200 IU / ml. Izi ndizofunikira kwambiri ngati wodwala agwiritsa ntchito ma insulin osiyanasiyana. Ngati atalakwitsa kupha insulin yamtundu wina, kuchuluka kwa shuga m'magazi kumatha kukhala kokwanira kwambiri kapena kotsika kwambiri.

A. Chotsani chipewa mu syringe cholembera.

B. Tsimikizani kuti kukonzekera kwa insulini mu cholembera kumamveka bwino komanso kopanda utoto. Onani pazenera la kukula kwa insulin. Ngati mankhwalawo ndi mitambo, cholembera sichingagwiritsidwe ntchito.

C. Tengani singano yatsopano yotaya ndikuchotsera chomata.

D. Ikani singano pa cholembera ndi kutembenuza kuti singano isapume pa cholembera.

E. Chotsani thumba lakunja la singano, koma osalitaya. Zidzafunika jekeseni litamalizidwa kuchotsa bwino singano mu cholembera.

F. Chotsani ndikutaya singano yamkati. Wodwalayo akafuna kubwezeretsa singano yamkati pabowo, angagwe.

Dontho la insulin lingathe kuoneka kumapeto kwa singano. Izi ndizabwinobwino, koma wodwalayo amayenerabe kufufuza insulin.

Chidziwitso chofunikira. Singano yatsopano iyenera kugwiritsidwa ntchito pobayira iliyonse. Izi zimachepetsa chiopsezo cha matenda, matenda, kuchepa kwa insulin, kutsekeka kwa singano ndikukhazikitsa njira yolakwika ya mankhwala.

Chidziwitso chofunikira. Osamagwiritsanso ndi singano ngati yakunga kapena yowonongeka.

II. Chingwe cha Insulin

G. Jekeseni aliyense asanaledzere, ayenera kuyamwa insulin. Izi zikuthandizira wodwala kuti awonetsetse kuti mlingo wa insulin ukuperekedwa kwathunthu.

Imbani 2 magawo a mankhwala ndikusintha chosankha. Onetsetsani kuti zida zotsalira zikuwonetsa "2".

H. Mukugwira cholembera ndi singano kumtunda, dinani mopepuka pamwamba pa cholembera kambirimbiri ndi cholembapo chanu kuti thovu lakutsogolo lisunthe.

I. Kanikizani batani loyambira ndikuligwirizitsa mpaka mawonekedwe atayamba kubwereranso ku "0". "0" akhale kutsogolo kwa chizindikiro. Dontho la insulin liyenera kuonekera kumapeto kwa singano. Mpweya wawung'ono ungakhale kumapeto kwa singano, koma osavulala. Ngati dontho la insulin silikuwoneka kumapeto kwa singano, bwerezaninso ntchito G - I (gawo II), koma osapitirira 6 times.

Ngati dontho la insulin silikuwoneka, sinthani singano ndikubwereza ntchito G - I kachiwiri (Gawo II).

Ngati dontho la insulin silikuwoneka kumapeto kwa singano, musagwiritse ntchito cholembera ichi. Gwiritsani ntchito cholembera chatsopano.

Chidziwitso chofunikira. Pamaso pa jekeseni iliyonse, onetsetsani kuti dontho la insulin limatuluka kumapeto kwa singano. Izi zimapangitsa kuti insulin iperekedwe. Ngati dontho la insulin silikuwoneka, mlingo wake sudzaperekedwa, ngakhale wotsutsa wa dokotalayo asunthe. Izi zitha kuwonetsa kuti singanoyo yaboweka kapena yowonongeka.

Chidziwitso chofunikira. Jekeseni iliyonse isanachitike, insulin iyenera kuyesedwa. Wodwala akapanda kuyamwa insulin, mwina sangathe kupereka insulin yokwanira kapena ayi, zomwe zingayambitse kuchuluka kwa shuga m'magazi.

III. Mlingo

J. Musanayambe jakisoni, onetsetsani kuti pulogalamu yotsitsa yaikidwa kuti "0". "0" akhale kutsogolo kwa chizindikiro. Tembenuzani chosankha cha mankhwalawa kuti muyike mlingo woyenera woperekedwa ndi dokotala.

Mlingo waukulu womwe wodwala amatha kukhazikitsa ndi 80 kapena 160 IU (wa Tresiba ® FlexTouch ® 100 IU / ml ndi Tresiba ® FlexTouch ® 200 IU / ml, motsatana).

Ngati mulingo woyipa wakhazikitsidwa, wodwalayo amatha kutembenuza osankhiratu a mankhwalawo kutsogolo kapena kumbuyo mpaka mulingo woyenera udzakhazikitsidwa.

Wosankha mlingo umayika kuchuluka kwa mayunitsi. Chidole chokhacho cha mlingo ndi chizindikiro chomwe chikuwonetsa kuchuluka kwa mitundu ya insulini mumtengowo.

Mlingo waukulu womwe wodwala amatha kukhazikitsa ndi 80 kapena 160 IU (wa Tresiba ® FlexTouch ® 100 IU / ml ndi Tresiba ® FlexTouch ® 200 IU / ml, motsatana).

Ngati insulin yotsalira mu cholembera sichikhala yocheperako 80 kapena 160 PIECES (ya Tresiba ® FlexTouch ® 100 PIECES / ml ndi Tresiba ® FlexTouch ® 200 PIECES / ml, motsatana), mlingo wa mankhwalawo udzaima pa chiwerengero cha insulin yomwe yasiyidwa mu cholembera.

Nthawi iliyonse pamene chosankha cholowa chitatemulidwa, kumveka kumveka, kumveka kwa mabatani kumadalira mbali yomwe wosankha wa mankhwalawo amatembenukira (kutsogolo, chammbuyo kapena ngati mlingo womwe watenga umaposa kuchuluka kwa zigawo za insulin zomwe zilipo mu syringe cholembera). Makina awa sikuyenera kuwerengedwa.

Chidziwitso chofunikira. Pamaso pa jekeseni iliyonse, ndikofunikira kuwunika kuchuluka kwa insulin yomwe wodwalayo adalipira pa kondomuyo. Osawerengetsa zokhoma za cholembera. Wodwala akangokhala ndikuyambitsa mtundu wolakwika, kuchuluka kwa shuga m'magazi kumatha kukhala kochulukira kapena kotsika kwambiri.

Mlingo wa insulini ukuwonetsa kuchuluka kwa insulini yotsalira mu cholembera, motero sangagwiritsidwe ntchito kuyeza kuchuluka kwa insulini

IV. Makulidwe a insulin

K. Ikani singano pansi pa khungu lanu pogwiritsa ntchito jakisoni woperekedwa ndi dokotala kapena namwino. Tsimikizani kuti mankhwala othandizira ali mgulu la odwala. Musakhudze gawo la mankhwalawo ndi zala zanu. Izi zitha kusokoneza jakisoni. Kanikizani batani loyambira njira yonse ndikuigwirizira mpaka nthawi yotsutsa idawonetsa "0". "0" iyenera kukhala yosiyana kwambiri ndi chizindikiro, pomwe wodwalayo amamva kapena kumva kudina.

Pambuyo pa jekeseni, siyani singano pansi pa khungu (osachepera 6 s) kuti muwonetsetse kuti jakisoni wathunthu wa insulin waperekedwa.

L. Chotsani singano pansi pa khungu ndikukoka chogwirizira ndi syringe.

Ngati magazi abwera pamalo a jakisoni, kanikizani kaye pang'ono thonje la thonje kumalowo. Musamasewetse malo a jakisoni.

Jakisoni itatha, wodwalayo amatha kuwona dontho la insulin kumapeto kwa singano. Izi ndizabwinobwino ndipo sizikhudza mlingo wa mankhwala omwe amaperekedwa.

Chidziwitso chofunikira. Nthawi zonse muziwonetsetsa kuti pali mankhwala angati a insulin omwe amaperekedwa. Kutsatsa kwa mlingo kukuwonetsa kuchuluka kwa mayunitsi. Osawerengera kuchuluka kwamadina onga syringe cholembera. Pambuyo pa jekeseni, gwiritsani batani loyambira mpaka wotsutsa wa mankhwalawo abwerere ku "0". Ngati mankhwala othandizira atayima asanawonetse "0", insulin yonse siyinalowe, zomwe zingayambitse kuchuluka kwa shuga m'magazi.

V. Mukamaliza jakisoni

M. Ikani kapu yakunja yachotchingira pamalo athyathyathya, ikani kumapeto kwa singano mu capuyo osakhudza kapena singano.

N. Pamene singano ilowa mu chipewa, ikani chovala mosamala. Tulutsani singano ndikuitaya, ndikuonetsetsa kuti pali chitetezo.

A. Pakatha jakisoni aliyense, ikani chophimba cholembera kuti mutchinjirize insulini yomwe ili nako kuti isakhudzidwe ndi kuwala.

Ponyani singano pambuyo pa jekeseni iliyonse. Izi zimachepetsa chiopsezo cha matenda, matenda, kuchepa kwa insulin, kutsekeka kwa singano ndikukhazikitsa njira yolakwika ya mankhwala. Ngati singano yatsekedwa, wodwalayo sangathe kubaya insulini.

Taya cholembera chogwiritsidwa ntchito ndi singano yolumikizidwa monga momwe adokotala aderetsera, anamwino, akatswiri a zamankhwala, kapena malamulo apafupi.

Chidziwitso chofunikira. Osayesera konse kubwezeretsa kapu yamkati pa singano. Wodwalayo amatha kuyamba kudandaula.

Chidziwitso chofunikira. Pakatha jakisoni aliyense, chotsani singano nthawi zonse ndikusunga cholembera kuti singano yake isokedwe. Izi zimachepetsa chiopsezo cha matenda, matenda, kuchepa kwa insulin, kutsekeka kwa singano ndikukhazikitsa njira yolakwika ya mankhwala.

VI. Kodi insulini yatsala bwanji?

P. Mulingo wotsalira wa insulin ukuwonetsa kuchuluka kwa insulini yotsalira mu cholembera.

R. Kuti mudziwe ndendende kuchuluka kwa insulini yomwe yasiyidwa, muyenera kugwiritsa ntchito kachipangizo kogwiritsa ntchito mlingo: kusinthanitsa chosankha cha mankhwalawo mpaka wotsutsa wa mankhwalawo atasiya. Ngati cholembera cha mankhwalawo chikuwonetsa kuchuluka kwa 80 kapena 160 (kwa mankhwalawa Tresiba ® FlexTouch ® 100 IU / ml ndi Tresiba ® FlexTouch ® 200 IU / ml, motsatana), izi zikutanthauza kuti osachepera 80 kapena 160 IU a insulin amakhala mu cholembera (mankhwalawo Tresiba ® FlexTouch ® 100 IU / ml ndi Tresiba ® FlexTouch ® 200 IU / ml, motsatana). Ngati cholembera cha mankhwalawo chikuwonetsa zosakwana 80 kapena 160 (kwa Tresiba ® FlexTouch ® 100 PIECES / ml ndi Tresiba ® FlexTouch ® 200 PIECES / ml, motsatana), izi zikutanthauza kuti ndendende kuchuluka kwa insulin yomwe ikuwonetsedwa pa cholembera ikhalabe mu cholembera Mlingo.

Sungani chosankha cha mtundu wina mpaka cholowa chikuonetsa "0".

Ngati insulini yotsala mu cholembera siyikwanira kuperekera mlingo wonse, mutha kulowetsamo ma jakisoni awiri pogwiritsa ntchito zolembera ziwiri.

Chidziwitso chofunikira. Chisamaliro chiyenera kutengedwa pakuwerengera gawo lotsalira la insulin.

Ngati wodwala akukayikira, ndibwino kuti mudzilowetse muyeso wa insulin yonse pogwiritsa ntchito cholembera chatsopano. Wodwala akakhala kuti walakwitsa pakawerengera, amatha kuyambitsa kuchuluka kosakwanira kapena kuchuluka kwambiri kwa insulini, zomwe zingayambitse kuti kuchuluka kwa shuga m'magazi kumatha kukhala kwakukulu kapena kotsika.

Nthawi zonse muyenera kunyamula cholembera.

Nthawi zonse muziyenera kunyamula cholembera ndi masingano atsopano ngati atayika kapena kuwonongeka.

Sungani cholembera ndi singano kuti aliyense asazifikire, makamaka ana.

Osasamutsa cholembera ndi singano ya wodwalayo kwa ena. Izi zimatha kudzetsa matenda opatsirana.

Osasamutsa cholembera ndi singano ya wodwalayo kwa ena. Mankhwalawa amatha kuvulaza thanzi lawo.

Osamalira amayenera kugwiritsa ntchito singano zogwiritsidwa ntchito mosamala kwambiri kuti achepetse vuto la njenjete ndi matenda opatsirana.

Chisamaliro cha cholembera

Chisamaliro chiyenera kutengedwa ndi cholembera. Kugwira mosasamala kapena kosayenera kungayambitse mlingo woyenera, womwe ungayambitse kuchuluka kwambiri kwa glucose kapena kutsika kwambiri.

Osasiya cholembera m'galimoto kapena malo ena aliwonse pomwe angayikidwe ndi kutentha kwambiri kapena kutentha kwambiri.

Tetezani cholembera ku fumbi, litsiro ndi mitundu yonse ya zakumwa.

Osasamba cholembera, osamiza m'madzi kapena kumuthira mafuta. Ngati ndi kotheka, cholembera cha syringe chimatha kutsukidwa ndi nsalu yonyowa pokonza yotsekemera ndi chowonjezera chofewa.

Osaponya kapena kugunda cholembera pamalo olimba. Wodwala akaponya cholembera kapena kuti akukayikira kuti ikugwira ntchito moyenera, ikani singano yatsopano ndikusanthula insulin musanapange jakisoni.

Osayesa kudzazitsa cholembera. Cholembera chopanda kanthu ziyenera kutayidwa.

Osayesa kukonzanso inunuyo yanu kapena kupatula.

Wopanga

Wopanga ndi mwini wa setifiketi yakulembetsa: Novo Nordisk A / S.

Novo Alle, DK-2880, Bugswerd, Denmark.

Zodandaula za ogula ziyenera kutumizidwa ku adilesi ya LLC Novo Nordisk: 121614, Moscow, ul. Krylatskaya, 15, wa. 41.

Tele. ((495) 956-11-32, fax: (495) 956-50-13.

Tresiba ®, FlexTouch ®, NovoFine ® ndi NovoTvist ® ndi zilembo zolembetsedwa ndi Novo Nordisk A / S, Denmark.