Glycvidon: mafotokozedwe, malangizo, mtengo

Imathandizira maselo a beta a pancreatic islets, imalimbikitsa kusunthika ndi kutulutsidwa kwa insulin, kutsitsa magazi m'magazi, ndikuwonjezera kuchuluka kwa insulin receptors mu minofu yomwe ikufuna. Mphamvu ya hypoglycemic imawonekera pambuyo pa mphindi 60-90, ikafika patali patatha maola awiri ndi atatu ndipo imatha maola 8.

Mwansanga komanso pafupifupi kutengeka kwathunthu kuchokera kugaya chakudya. C_max zimatheka pambuyo maola 2-3.Matenda a chiwindi. T_1/2 - Maola 1.5. Amakumbidwa makamaka ndi matumbo (okhala ndi ndulu ndi ndowe), komanso pang'ono (5%) - ndi impso.

Kuchita

Zotsatira zake zimapangidwira ndi butadione, chloramphenicol, tetracyclines, coumarin derivatives, cyclophosphamide, sulfonamides, mao inhibitors, thiazide diuretics, beta-blockers, salicylates, mowa, komanso ofooka ndi njira zakulera zapakati pamlomo, chlorpromazine, mazweru, mafupa am'mimba, ma cympids. Zimagwirizana ndi Biguanides.

Kusamala Glycvidone

Pa mankhwala, kuwunika shuga m'magazi ndi mkodzo, kudya ndikofunikira. Kudumpha chakudya kapena kupitirira muyeso kumatha kubweretsa mphamvu yotchedwa hypoglycemic. Ndi chithandizo cha opaleshoni, matenda ophatikizidwa ndi kutentha kwambiri kwa thupi, pangafunike kusamutsa kwakanthawi wodwala ku insulin. Kulephera kwambiri kwa aimpso, kuyang'aniridwa nthawi zonse kwachipatala ndikofunikira. Kuthekera kwochepetsa kulekerera mowa kuyenera kuganiziridwanso.

Mtengo wa Glycidon komanso kupezeka kwa mankhwala ogulitsa mzindawu

Yang'anani! Pamwambapa pali tebulo lowoneka bwino, zambiri zitha kukhala kuti zasintha. Zambiri pa mitengo ndi kupezeka kwake zimasintha pa nthawi yeniyeni kuti muwone - mutha kugwiritsa ntchito kusaka (nthawi zonse zidziwitso pofufuza), komanso ngati mungafunike kusiya lamulo lamankhwala, sankhani malo amzindawu kuti mupeze kapena mupeze pokhapokha pokhapokha mankhwala.

Mndandanda womwe uli pamwambapa umasinthidwa pafupifupi maola 6 aliwonse (unasinthidwa pa 07/13/2019 nthawi ya 20: 16 - nthawi ya Moscow). Fotokozani mitengo ndi kupezeka kwa mankhwalawa posaka (batani losakira lili pamwamba), komanso manambala a foni asananyamuke. Zomwe zili patsamba lino sizingagwiritsidwe ntchito ngati njira zodziyambitsira nokha. Musanagwiritse ntchito mankhwala, onetsetsani kuonana ndi dokotala.

Glycvidon: malangizo, ntchito, ndemanga, kugwiritsa ntchito

M'nthawi yathu ino, mliri wa matenda ashupi tsopano wakhala vuto lofunika kwambiri kwa anthu onse. Nthawi yomweyo, 90% ya onse odwala matenda ashuga ali ndi mtundu wachiwiri wa matenda.

Kwenikweni, glycidone amatengedwa ndi odwala omwe kuchita masewera olimbitsa thupi komanso kudya moyenera sangachepetse kuchuluka kwa glucose muzikhalidwe zabwino.

Musanagwiritse ntchito mankhwala okhala ndi chinthu ichi, ma contraindication ake, zoyipa zake komanso chidziwitso chokhudza analogues chikuyenera kuphunziridwa.

Makhalidwe azinthu zambiri

Glycvidone ndi ufa wowoneka bwino wa kristalo. Sungathe kusungunuka m'madzi, sikuti amasudzulidwa mu mowa. Mankhwala ali ndi hypoglycemic.

Chifukwa chakuti shuga mellitus wamtundu wachiwiri amadziwika ndi kuphwanya kwamphamvu kwa maselo a thupi kupita ku timadzi timene amatsitsa shuga - insulin, mankhwala omwe amagwiritsidwa ntchito popanga mankhwala amakhudzana ndi kapamba ndi zolandilira zotumphukira.

Amayendedwe a machitidwe ake amachita ndikulimbikitsa maselo a beta omwe amapanga insulin, kutsitsa kuchuluka kwa glucagon, ndikuchulukitsa kuchuluka kwa mahomoni olandirira.

Wodwala yemwe adamwa mankhwalawa, pambuyo pa maola 1 mpaka 1.5, kuchepa kwa shuga kumawonedwa, mphamvu zake zimadza pambuyo pa maola 2-3 ndipo zimatha pafupifupi maola 8. Thupi limatengedwa mwachangu m'mimba. Kutupa kwake kumachitika kudzera m'matumbo (ndi ndowe ndi bile), komanso impso.

Glycvidone imalembedwa kwa anthu azaka zopitilira 45, pamene kudya moyenera komanso kuchita masewera olimbitsa thupi sikubweretsa zotsatira zomwe zikufunidwa ndikuwonjezereka kwa shuga wamagazi.

Malangizo ogwiritsira ntchito mankhwalawa

Asanagwiritse ntchito Glycvidon, wodwala matenda ashuga ayenera kufunsa dokotala kuti apereke njira yoyenera ya mankhwala ndi kumwa, poganizira zomwe wodwalayo ali nazo. Pofuna kupewa zoyipa, malangizo omwe agwiritsidwe ntchito ayenera kuphunziridwa.

Ku Glyurenorm, glycidone ndiye gawo lalikulu lomwe limakhala ndi hypoglycemic. Amapezeka mu mawonekedwe a mapiritsi oyera. Mankhwalawa amatengedwa pakamwa pakudya.

Mlingo woyambirira ndi mapiritsi 0,5 (15 mg) nthawi ya chakudya cham'mawa. Kuti mukwaniritse bwino, mlingo umatha kuwonjezeka mpaka mapiritsi 4 (120 mg) patsiku.

Pankhaniyi, kuchuluka kwa mlingo woposa 120 mg sikupangitsa kuti achulukane.

Pakusintha kuchokera ku mankhwala ena ochepetsa shuga, koyamba kudya kuyenera kukhala kochepa (15-30 mg).

Pewani Glurenorm kutali ndi ana aang'ono, m'malo owuma ndi kutentha kosaposa 25C. Pakukhazikitsa kwa mankhwala kuyenera kufotokozedwera tsiku lotha ntchito, lomwe nthawi zambiri limakhala zaka 5.

Pambuyo pa nthawi iyi, kumwa mapiritsi ndizoletsedwa.

Contraindication ndi zoyipa zimachitika

Kudzilanga nokha ndi mankhwalawa ndikosayenera kwambiri. Kugwiritsa ntchito mankhwalawooletsedwa motere:

1. Mtundu woyamba wa matenda a shuga 1 mellitus (mawonekedwe a insulin).
2. Kusagwirizana ndi zigawozi (makamaka, kuchokera ku sulfonamides ndi sulfonylureas).
3. Diabetesic acidosis (hypoglycemia ndi ketonemia).
4. Nthawi isanachitike opareshoni.
5. Matenda a shuga.
6. Precoma.
7. Mimba
8. Nthawi yochepetsetsa.

Nthawi zina, maonekedwe a zovuta zina monga hypoglycemia, ziwengo (zotupa pakhungu, urticaria, matenda a Stevens-Johnson, kuyabwa), kusintha kwa kapangidwe ka magazi, kuphwanya njira zamkati zam'mimba (kutsegula m'mimba, kusanza). Zizindikiro zotere zikawoneka, mungafunike kusintha mankhwalawo ndi analogue ina.

Pankhaniyi, chisamaliro chapadera chiyenera kulipidwa kwa odwala omwe ali ndi vuto la impso. Mankhwalawa amayenera kumwedwa moyang'aniridwa ndi adokotala.

Kugwiritsidwa ntchito kophatikizana ndi mankhwala ena, monga sympathomimetics, mahomoni a chithokomiro, kulera kwamlomo, chlorpromazine, sympathomimetics, ndi mankhwala okhala ndi nicotinic acid kungafooketse mphamvu ya Glycvidone.

Pakakhala mankhwala osokoneza bongo ambiri, zizindikilo zomwe zimafanana ndi zovuta zimatha kuwoneka. Kuti matenda akhale ndi shuga, muyenera kulowererapo shuga m'mitsempha kapena mkati.

Ndemanga, mtengo wake ndi kufanana

Mankhwalawa, odwala ambiri amawona zabwino chifukwa chogwiritsidwa ntchito ndi Glycvidon wopezeka mu mankhwala a Glyurenorm. Ndemanga zamakasitomala zimanenanso kutsatira izi:

Panthawi yomwe mumamwa mankhwalawa, munthu sayenera kuyiwala za zakudya komanso ntchito zapanja. Zakudya zopanda pake kapena kusamwa mosayembekezereka zimapangitsa kuchepa kwa shuga mwa odwala ena. Chifukwa chake, kutsatira malamulo a tsikulo ndi malamulo a chithandizo ndi mankhwalawa ndikofunikira kwambiri.

Pakachitika vuto la hypoglycemic, mutha kudya chidutswa cha chokoleti kapena shuga. Koma ndikupitiliza kwa vutoli, muyenera kulankhulana ndi dokotala mwachangu.

Pakusintha kuchokera ku mankhwala kupita ku wina, odwala ena adawonetsa kuchepa kwa chidwi, kotero izi ziyenera kukumbukiridwa kwa oyendetsa magalimoto ndi zina zambiri zofunikira zomwe zimafunikira chidwi kwambiri.

Zokhudza mitengo, ndizodalirika kwa odwala omwe ali olemera. Mtengo wa phukusi la Glurenorm, wokhala ndi mapiritsi 60 a 30 mg aliyense, kuyambira 385 mpaka 450 rubles. Dziko lopanga mankhwalawa ndi Germany. Mankhwalawa atha kugulidwa ku malo aliwonse apafupi ndi mankhwala kapena kuyitanitsa kuti atenge mapiritsi pa intaneti. Mankhwalawa amagulitsidwa kokha ndi mankhwala.

Ngati, pazifukwa zilizonse, mankhwalawa sioyenera kwa wodwala, dokotala amatha kusintha njira yochiritsira mwa kupereka mankhwala ofananawo kuti achepetse shuga. Zofanizira zazikulu za Glyurenorm ndi:

• Amaril (1150 rubles),
• Maninil (ma ruble 170),
• Gluconorm (ma ruble 240),
• Mkulu wodwala matenda ashuga (ma ruble 350).

Ndipo, Glyrenorm, yomwe imakhala ndi glycidone yogwira ntchito, imatsitsa shuga, imalimbikitsa maselo a pancreatic beta ndikusintha chidwi cha zolandilira thupi.

Komabe, monga mankhwala aliwonse, ili ndi zotsutsana ndipo limakumana ndi zovuta. Chifukwa chake, kutenga nokha sikulimbikitsidwa.

Choyamba muyenera kuwona dokotala yemwe amatha kuyesa wodwala ndikupereka njira zoyenera zamankhwala.

Kumbukirani kuti mlingo woyenera komanso kukhalabe wathanzi pamagulu a shuga m'magazi a odwala matenda ashuga. nkhaniyi ikuwuzanso zomwe ungatenge ndi matenda ashuga.

Sonyezani shuga yanu kapena sankhani jenda kuti muyimikize.

Zisonyezero zogwiritsidwa ntchito ndi mawonekedwe a Glycvidon wa mankhwala

Kuwongolera shuga ndimwazi ndikomwe kuli nkhondo yayikulu yolimbana ndi matenda ashuga.

Ngati sizotheka kukhalabe ndi masewera olimbitsa thupi ndi zakudya komanso masewera olimbitsa thupi, othandizira a hypoglycemic ayenera kugwiritsidwa ntchito. Ena mwa iwo amatha kutchedwa kuti Glycvidon, yemwe amadziwika ndi dzina la malonda Glyurenorm.

Zambiri

Mankhwala amatengera chinthu chomwe chili ndi dzina lomweli. Ili ndi katundu wachilengedwe. Mankhwalawa cholinga chake ndi kuthana ndi matenda osokoneza bongo omwe amadalira shuga.

Gawo lake lalikulu limakhala ndi mawonekedwe a ufa woyera, womwe umasungunuka pang'ono mu mowa ndipo sungasungunuke m'madzi.

Popeza wothandizirayu amakhudza kuchuluka kwa shuga m'magazi, kugwiritsa ntchito mankhwalawa mosasamala kumayambitsa kusokonezeka kwa ntchito ya thupi yokhudzana ndi hypoglycemia. Chifukwa chake, odwala ayenera kutsatira malangizo kuchokera kwa katswiri.

Kuphatikizika, mawonekedwe omasulidwa

Kuphatikiza pa mankhwala a glycidone, omwe ali osakanikirana ndi mankhwalawo, mumakhala zinthu monga:

• wowuma chimanga
• lactose monohydrate,
• stesiate wa magnesium, etc.

Mankhwala amapangidwa ngati mapiritsi amtundu wa mkati. Aliyense wa iwo ali ndi 30 mg ya glycidone. Mapiritsiwo ndi ozungulira mawonekedwe ndi oyera. Tizidutswa 10 tikugulitsa m'matumba. Paketi imatha kukhala ndi matuza 3, 6 kapena 12.

Zizindikiro ndi contraindication

Amayenera kugwiritsa ntchito mankhwalawa pokhapokha ngati pakufunikira kudziwa koyenera. Mwanjira ina iliyonse, mankhwalawa amatha kuvulaza wodwala. Glycvidone ayenera kugwiritsidwa ntchito pa matenda a shuga a 2. Amawerengera ngati gawo la zovuta mankhwala kapena ngati chida chosiyana.

Ndi koletsedwa kugwiritsa ntchito mankhwalawa pamaso pa contraindication.

• tsankho pakuchokera,
• wodwala matenda ashuga komanso prekom,
• acidosis
• ketoacidosis
• Mtundu woyamba wa matenda a shuga
• mimba
• kudya kwachilengedwe
• zaka za ana.

Muzochitika zotere, madokotala amapereka mankhwala omwe ali ndi vuto lofananalo, koma osaletsedwa chifukwa cha zomwe zalembedwazo.

Odwala Apadera ndi Mayendedwe

Odwala omwe malamulo ake amawagwirira ntchito amaphatikizapo:

1. Amayi oyembekezera. Mu maphunziro, sizinakhazikitsidwe ngati gawo logwira limalowa mu placenta, chifukwa chake sizikudziwika ngati Glycvidone angakhudze mayeso a gestation. Pankhaniyi, mapiritsi awa sanatchulidwe kwa amayi oyembekezera.
2. Amayi oyamwitsa. Palibe chidziwitso cha mphamvu ya mkaka wa m'mawere. Izi zikutanthauza kuti simuyenera kugwiritsa ntchito mankhwalawa mukamayamwa.
3. Ana ndi achinyamata. Kuchita bwino komanso chitetezo cha mankhwalawa m'gulu la odwala sizinafufuzidwebe. Popewa zovuta zomwe zingachitike, akatswiri samapereka Glycvidon kwa odwala matenda ashuga osakwana zaka zambiri.
4. Anthu okalamba. Pakakhala matenda akulu, kugwiritsa ntchito mankhwalawo kumaloledwa. Ngati wodwala akukumana ndi vuto la chiwindi, mtima kapena impso, ndiye kuti kusintha kwazithandizo kungakhale kofunikira.
5. Odwala omwe ali ndi matenda a impso. Mankhwala ambiri a hypoglycemic amachotsedwa ndi impso, chifukwa chake, ngati kuphwanya kwazomwe kumagwira, kuchepetsa mlingo kumafunika. Glycvidone imachotsedwedwa ndi matumbo, impso zimakhala kuti sizikuchita nawo izi, choncho palibe chifukwa chosinthira.
6. Anthu omwe ali ndi vuto la chiwindi. Mankhwalawa amakhudza chiwindi. Komanso m'thupi mthupi mumakhala kagayidwe kazinthu zomwe zimagwira. Pankhaniyi, kukhalapo kwa ma metabolism a chiwindi kumafuna kusamala mukamagwiritsa ntchito Glycvidon. Nthawi zina, kugwiritsa ntchito kwake nkoletsedwa, ngakhale nthawi zambiri muyenera kuchepetsa gawo la mankhwalawo.

Mutha kuwonjezera mphamvu ya mankhwalawa mothandizidwa ndi zakudya komanso zolimbitsa thupi. Zonsezi, ndi zina zimalimbikitsa kuthamanga kwa shuga ndi chamoyo, chifukwa chake nkotheka kugwiritsa ntchito mankhwala akulu kwambiri.

Zotsatira zoyipa, bongo

Kupezeka kwa zoyipa nthawi zambiri kumachitika chifukwa chophwanya malangizo - kuwonjezera kuchuluka kapena kumwa mapiritsi, ngakhale mutatsutsana.

Nthawi zambiri, odwala amadandaula zotsatirazi:

• achina,
• nseru
• mutu
• kuchepa kwamtima
• Khungu
• zotupa.

Mankhwala othandizira amathandizira kuthetsa mawonetseredwe a pathological. Ena a iwo amadzichotsa okha atasiya mankhwala. Chifukwa chake, ngati apezeka, ndikofunikira kufunsa dokotala.

Kuchulukitsa mlingo kungayambitse matenda a hypoglycemic. Mfundo yakuchotsedwako imatengera kuuma kwake. Nthawi zina zimakhala zokwanira kudya chakudya chamafuta ambiri. Nthawi zina, thandizo ladzidzidzi lofunikira limafunikira.

Glurenorm - mankhwala a hypoglycemic zochizira matenda amitundu iwiri

Glurenorm ndi mankhwala omwe ali ndi vuto la hypoglycemic. Matenda a 2 a shuga ndi vuto lofunikira kwambiri chachipatala chifukwa cha kuchuluka kwake komanso zovuta zake. Ngakhale ndi kulumpha kwakung'ono m'magazi a glucose, mwayi wa retinopathy, kugunda kwa mtima kapena stroko ukuwonjezeka kwambiri.

Glurenorm ndi amodzi mwa owopsa kwambiri pazotsatira zoyipa za antiglycemic othandizira, koma siwotsika mtengo pogwira mankhwala ena omwe ali mgululi.

Pharmacokinetics

Mutatenga gawo limodzi mkati, Glyurenorm imamwedwa mwachangu komanso pafupifupi (80-95%) kuchokera m'mimba yotsekemera mwakuthira.

Mankhwala othandizira - glycidone, ali ndi kuyanjana kwakukulu kwa mapuloteni m'madzi a m'magazi (99%). Palibe chidziwitso pakuyenda kapena kusapezeka kwa chinthuchi kapena zinthu zake za metabolic pa BBB kapena placenta, komanso kutulutsidwa kwa glycvidone mkaka wa mayi woyamwitsa panthawi yoyamwitsa.

Glycvidone imakonzedwa mu 100% m'chiwindi, makamaka kudzera m'mitsempha. Zinthu zomwe zimapangidwa ndi kagayidwe kake ndizopanda ntchito za pharmacological kapena zimafotokozedwa mofooka kwambiri poyerekeza ndi glycidone yokha.

Zinthu zambiri za kagayidwe ka glycidone zimasiya thupi, kukhala zotulutsidwa m'matumbo. Kachigawo kakang'ono ka zinthu zopasuka zomwe zimatuluka kudzera impso.

Kafukufuku wapeza kuti pambuyo pa kayendetsedwe ka mkati, pafupifupi 85% ya mankhwala osokoneza bongo a isotope amatulutsidwa m'matumbo.Mosasamala za kukula kwa mlingo komanso njira yoyendetsera kudzera mu impso, pafupifupi 5% (mu mawonekedwe a zinthu za metabolic) yamavomerezo amtunduwo amamasulidwa. Mlingo wa kumasulidwa kwa mankhwala kudzera mu impso umakhalabe wocheperako ngakhale pakudya pafupipafupi.

Pharmacokinetics ndi chimodzimodzi mwa odwala okalamba komanso azaka zapakati.

Kuposa 50% ya glycidone imatulutsidwa m'matumbo. Malinga ndi chidziwitso china, kagayidwe ka mankhwala sikusintha mwanjira iliyonse ngati wodwala walephera. Popeza glycidone imachoka m'thupi kudzera mu impso yaying'ono, odwala omwe ali ndi vuto la impso, mankhwalawa saunjikira m'thupi.

Type 2 matenda ashuga okalamba komanso okalamba.

Gwiritsani ntchito ntchito yolakwika ya chiwindi

Mankhwala ali contraindicated mu pachimake hepatic porphyria, chiwindi.

Kumwa mlingo wowonjezera wa 75 mg kwa odwala omwe ali ndi vuto la chiwindi kumafunikira kuwunika momwe wodwalayo alili. Mankhwalawa sayenera kutumizidwa kwa odwala omwe ali ndi vuto lalikulu la chiwindi, popeza 95% ya mankhwalawa imapukusidwa mu chiwindi ndikuchotsa matumbo.

M'mayesero azachipatala odwala omwe ali ndi vuto la shuga komanso kuperewera kwa chiwindi kosiyanasiyana (kuphatikiza pachimake chiwindi cirrhosis ndi matenda oopsa a portal), Glurenorm® sinayambitse kuwonongeka kwa chiwindi, kuchuluka kwa zovuta sikunawonjezeke, kusintha kwa hypoglycemic sikunapezeke.

Gwiritsani ntchito ntchito yolakwika yaimpso

Popeza gawo lalikulu la mankhwalawa limapukusidwa m'matumbo, odwala omwe ali ndi vuto laimpso, mankhwalawa samadziunjikira. Chifukwa chake, glycidone imatha kuperekedwa kwa odwala omwe ali pachiwopsezo chokhala ndi nephropathy yodwala.

Pafupifupi 5% ya metabolites ya mankhwalawa amachotsedwa ndi impso.

Mu kafukufuku wazachipatala - kuyerekezera kwa odwala omwe ali ndi matenda osokoneza bongo komanso kuwonongeka kwaimpso kosiyanasiyana komanso odwala omwe ali ndi vuto la shuga popanda kuwonongeka kwa impso, kutenga Glyurenorm pa mlingo wa 40-50 mg kunayambitsa zotsatira zofanana zamagazi. Kudzikundikira kwa mankhwalawa ndi / kapena hypoglycemic zizindikiro sizowonedwa. Chifukwa chake, odwala omwe ali ndi vuto la impso, kusintha kwa mlingo sikofunikira.

Malangizo apadera

Odwala omwe ali ndi matenda ashuga ayenera kutsatira mosamalitsa zomwe adotolo adachita. Kuwongolera mosamala makamaka posankha mlingo kapena mukamasintha kuchokera ku mankhwala ena a hypoglycemic.

Othandizira pakamwa sayenera kuthana ndi zakudya zomwe zimakupatsani mwayi wopewa kulemera kwamthupi.

Kudumpha chakudya kapena osatsatira zomwe dokotala wakupangira kungachepetse kuthamanga kwa shuga m'magazi anu ndikuwapangitsa kuti musataye mtima.

Mukamamwa mapiritsi musanadye, ndipo osavomerezeka, kumayambiriro kwa chakudyacho, mphamvu ya mankhwala omwe amapezeka m'magazi m'magazi limatchulidwa kwambiri, zomwe zimawonjezera chiopsezo cha hypoglycemia.

Ngati muli ndi zizindikiro za hypoglycemia, muyenera kudya nthawi yomweyo zakudya zokhala ndi shuga. Pankhani ya kupitiriza kwa hypoglycemic state, muyenera kufunsa dokotala nthawi yomweyo.

Kuchita masewera olimbitsa thupi kumatha kukulitsa zotsatira za hypoglycemic.

Mowa kapena kupsinjika kumatha kuwonjezera kapena kuchepetsa mphamvu ya hypoglycemic ya sulfonylureas.

Kugwiritsa ntchito mankhwala a sulfonylurea kwa odwala omwe ali ndi vuto la shuga-6-phosphate dehydrogenase kungayambitse kuchepa kwa magazi m'thupi. Chifukwa

Glurenorm ® ndi sulfonylurea yotumphukira, chisamaliro chiyenera kutengedwa mukamagwiritsa ntchito mankhwala omwe ali ndi vuto la shuga-6-phosphate dehydrogenase ndipo ngati kuli kotheka, lingaliro lipangidwe pankhani yosintha mankhwalawa.

Piritsi limodzi la Glurenorm® pre-product lili 134.6 mg wa lactose (538.4 mg wa lactose muyezo waukulu tsiku lililonse). Odwala omwe ali ndi matenda achilengedwe obadwa nawo monga galactosemia, kuchepa kwa lactase, glucose-galactose malabsorption sayenera kumwa Glurenorm ®.

Glycvidone ndi sulfonylurea yochokera kwa nthawi yayitali motero amagwiritsidwa ntchito mwa odwala omwe ali ndi matenda a shuga a 2 omwe ali ndi chiopsezo chowonjezeka cha hypoglycemia, mwachitsanzo, odwala okalamba ndi odwala omwe ali ndi vuto laimpso.

Popeza glucidone excretion wa impso ndiwosagwirizana, Glurenorm ® ikhoza kugwiritsidwa ntchito kwa odwala omwe amatsutsana ndi aimpso ndi nephropathy. Komabe, chithandizo cha odwala omwe ali ndi vuto laimpso liyenera kuchitidwa moyang'aniridwa ndi achipatala.

Pali umboni wosonyeza kuti kugwiritsa ntchito glycidone kwa odwala omwe ali ndi matenda amtundu wa 2 omwe ali ndi matenda amtundu wa chiwindi ndi othandiza komanso otetezeka. Kuchotsa kwa metabolites kosagwira mwa odwala koteroko kumachedwa. Komabe, odwala omwe ali ndi matenda osokoneza bongo omwe ali ndi vuto la shuga komanso kuwonongeka kwakukulu kwa hepatic, kugwiritsa ntchito mankhwalawa sikulimbikitsidwa.

Pa maphunziro azachipatala, zidapezeka kuti kugwiritsa ntchito mankhwalawa Glyurenorm ® kwa miyezi 18 ndi 30 sizinachititse kuti thupi lizikula, ngakhale milandu yotsika thupi ndi 1-2 kg idadziwika. Kafukufuku wofananizira ndi zotumphukira zina za sulfonylurea, zidawonetsedwa kuti odwala omwe akutenga Glurenorm ® kwa nthawi yoposa chaka alibe kusintha kwakukuru m'thupi.

Kukopa pa kuyendetsa magalimoto ndi kayendedwe kazinthu

Palibe chidziwitso pakugwiritsa ntchito mankhwalawa pakutha kuyendetsa magalimoto ndi machitidwe.

Komabe, odwala akuyenera kuchenjezedwa za mawonekedwe a hypoglycemia monga kugona, chizungulire, chisokonezo chogona, chomwe chitha kuchitika mukamamwa mankhwalawa.

Chisamaliro chikuyenera kuthandizidwa poyendetsa magalimoto ndi makina. Mu zochitika za hypoglycemic, muyenera kupewa kuyendetsa magalimoto ndi magwiridwe antchito.

Kupanga ndi mawonekedwe a kumasulidwa

"Glurenorm" - mapiritsi oyera a pakamwa.

Piritsi lililonse lili ndi:

• Chofunikira chachikulu: glycidone - 30 mg,
• Zigawo zothandiza: lactose monohydrate, wowuma chimanga wowuma, mafuta wowuma a chimanga, magnesium stearate.

Kulongedza. Matumba a mapiritsi 10 (3, 6, 12 ma PC.). Phukusi la makatoni, malangizo.

Zochizira

"Glurenorm" ndi mankhwala a hypoglycemic operekera pakamwa, ndi sulfonylurea yotengera mibadwo iwiri. Ili ndi pancreatic komanso extrapancreatic kanthu.

Zimapangitsa secretion ya insulin, ndikupanga njira ya shuga mkati mwa kapangidwe ka insulin.

Mothandizidwa, zidapezeka kuti Glurenorm imachepetsa kukana kwa insulini mu minofu ya adipose ndi chiwindi ndikuwonjezera ma insulin receptors, komanso kuyambitsa njira ya post-receptor yomwe imayendetsedwa ndi insulin.

Zotsatira za hypoglycemic zimachitika pakapita mphindi 60-90. mutamwa kumwa mkatikati, mphamvu yake imayamba ndi maola 2-3 ndipo imatenga maola 10.

Type 2 shuga mellitus mwa anthu azaka zapakati komanso okalamba (pakadalibe zotsatira za mankhwalawa).

Njira yogwiritsira ntchito

"Glurenorm" imapangidwira kukonzekera kwamlomo, ndi chakudya chokakamizidwa. Mlingo woyamba, monga lamulo, ndi tebulo la 1/2. kapena 15 mg pa chakudya cham'mawa. Mankhwala amatengedwa musanadye. Mukatha kugwiritsa ntchito Glyurenorma, simungadumphe chakudya.

Mukamamwa 15 mg ya mankhwalawa sizimabweretsa kusintha kokwanira, dokotala amawonjezera mlingo. Ngati tsiku lililonse mankhwala osapitilira 2 mapiritsi (60 mg), akhoza kutumikiridwa mu 1 mamawa.

Mukapereka mankhwala okwanira, zotsatira zabwino zimapezeka pakuphwanya muyezo wa 2 kapena 3 waukulu. Zikakhala choncho, mlingo woyenera kwambiri uyenera kumwedwa m'mawa. Kuwonjezeka kwa tsiku lililonse mapiritsi oposa 4. (120 mg) mtsogolomo, monga lamulo, sizitsogolera pakuwonjezeka kwa ntchito yabwino.

Pazipita tsiku lililonse mapiritsi 4 kapena 120 mg.

Odwala omwe ali ndi vuto laimpso, sayenera kumwa mwapadera.

Odwala omwe ali ndi vuto la chiwindi, kutumikiridwa kwa Mlingo wa tsiku ndi tsiku wopitirira 75 mg kumafunikira kuwunika momwe wodwalayo alili.

Metformin yokha ndi yomwe ingagwiritsidwe ntchito ngati mankhwala othandizira osakwanira kwenikweni kwa Glyurenorm.

Zotsatira zoyipa

• Thrombocytopenia, leukopenia, agranulocytosis.
• Hypoglycemia.
• Mutu ndi chizungulire, kugona, kumva kutopa, paresthesia.
• Kuphwanya malo okhala.
• Angina pectoris, kulephera kwamtima, kuthamangitsidwa kwa mtima, hypotension.
• Kuchepetsa chilala, kusanza ndi kusanza, kudzimbidwa kapena kutsegula m'mimba, kusapeza bwino m'mimba, pakamwa kowuma, cholestasis.
• Rash, kuyabwa, urticaria, photosensitivity, Stevens-Johnson.
• Ululu kumbuyo kwa sternum.

Bongo

Mankhwala osokoneza bongo a Glurenorm angayambitse hypoglycemia, yomwe imayendetsedwa ndi tachycardia, kuchuluka thukuta, njala, palpitations, kunjenjemera, kupweteka mutu, kusowa tulo, kusakhazikika, kuyankhula kwamiseche komanso masomphenya, nkhawa yamagalimoto komanso kutaya chikumbumtima.

Chithandizo: insa glucose kapena zakudya zamafuta ambiri. Vuto loti hypoglycemia itayika chifukwa cha kusowa kapena chikomokere, uyenera kuthandizidwa ndi dextrose iv. Pambuyo pozindikira, wodwalayo ayenera kugawa chakudya chambiri (makeke, shuga, madzi otsekemera) mkati, kuti apewe kubwereza kwa hypoglycemia.

CHOKONZEDWA MALO OGULITSA

Glurenorm: malangizo, ntchito, analogi, mtengo, ndemanga

Nthawi zambiri, odwala matenda ashuga a 2 amakonda kudziwa momwe angatengere glurenorm. Mankhwalawa ndi a amodzi omwe amachepetsa shuga kuchokera pagulu lachiwiri la sulfonylurea.

Ili ndi mtundu wa hypoglycemic wotchulidwa ndipo nthawi zambiri imagwiritsidwa ntchito pochiza odwala omwe ali ndi matenda oyenera.

Gawo lalikulu la mankhwala Glenrenorm ndi glycidone.

Othandizira ndi:

• Wowuma ndi wowuma chimanga wowuma.
• Magnesium wakuba.
• Lactose Monohydrate.

Glycvidone ali ndi hypoglycemic. Momwemo, chizindikiritso chogwiritsa ntchito mankhwalawa ndi mtundu wa 2 shuga wambiri pomwe chakudya chokha sichingapangitse kuchuluka kwa shuga m'magazi.

Mankhwala Glurenorm ndi a gulu la zotumphukira za sulfonylurea, chifukwa chake zotsatira zake zimagwirizana kwathunthu (nthawi zambiri) ndi othandizira ofananawo.

Zotsatira zazikulu zochepetsera kuchuluka kwa shuga ndi zotsatirazi zamankhwala:

1. Kukondoweza kwa amkati a insulin.
2. Kuchulukana kwamphamvu kwa zotumphukira zathu kuzinthu zokhudzana ndi mphamvu ya timadzi.
3. Kuwonjezeka kwa chiwerengero cha insulin receptors.

Chifukwa cha izi, nthawi zambiri zimakhala zotheka kusinthasintha magazi a glucose.

Mankhwala a glucorm angagwiritsidwe ntchito pokhapokha mukaonana ndi dokotala ndikusankha Mlingo wokwanira wodwala wina. Kudzichitira nokha mankhwala kumaperekedwa chifukwa chokhala ndi chiopsezo chambiri komanso kuwonjezeka kwa zomwe wodwalayo amadwala.

Njira zochizira mtundu wachiwiri za matenda a shuga a mankhwalawa zimayamba ndi theka la piritsi (15 mg) patsiku. Glurenorm imatengedwa m'mawa kumayambiriro kwa chakudya. Pakufunika kwa zotsatira za hypoglycemic, mlingo umalimbikitsidwa kuti uwonjezeke.

Ngati wodwalayo amadya mapiritsi awiri a Glyurenorm patsiku, ndiye kuti ayenera kumwedwa panthawi yotsegula chakudya. Ndi kuwonjezeka kwa tsiku ndi tsiku mlingo, ayenera kugawidwa zingapo Mlingo, koma gawo lalikulu la yogwira zimayenera kutsalira m'mawa.

Mlingo wambiri tsiku lililonse ndikumwa mapiritsi anayi. Kuwonjezeka koyenera kwa mankhwalawa ndikuwonjezeka kwa kuchuluka kwa mankhwalawa mopitilira chiwerengerochi sikunawonedwe. Chiwopsezo chokha cha kukulitsa zovuta zomwe zimachitika chimawonjezeka.

Simunganyalanyaze njira yodya mukatha kugwiritsa ntchito mankhwalawa. Ndikofunikanso kugwiritsa ntchito mapiritsi ochepetsera shuga panjira (koyambirira) kwa chakudya. Izi zikuyenera kuchitika pofuna kupewa matenda a hypoglycemic ndi chiopsezo chochepa cha kukhala chikomokere (cha mankhwala osokoneza bongo).

Odwala omwe ali ndi vuto la chiwindi ndipo amatenga mapiritsi a Glurenorm opitilira awiri patsiku ayenera kuwunikiridwa pafupipafupi ndi dokotala kuti ayang'anire ntchito ya chiwalocho.

Kutalika kwa mankhwalawa, kusankha kwa Mlingo ndi malingaliro pazomwe mungagwiritse ntchito ziyenera kuyikidwa ndi adokotala okha. Kudzichitira nokha mankhwala kuli ndi zovuta zingapo zamatenda oyamba ndikubwera pazotsatira zingapo zosayenera.

Ndi kusakwanira kwenikweni kwa Glyurenorm, kuphatikiza kwake ndi Metformin ndikotheka. Funso la kuchuluka kwa mankhwalawa komanso kugwiritsa ntchito mankhwala mosokoneza bongo kumawerengedwa pambuyo pa kuyesedwa koyenera kachipatala ndi kufunsa kwa endocrinologist.

Analogi a njira

Popeza ndi mitundu yambiri ya mankhwala omwe amagwiritsidwa ntchito pochiza matenda amtundu wa 2, odwala ambiri ali ndi chidwi ndi momwe angachotse Glurenorm. Ndikofunika kudziwa kuti kusiyanasiyana kwa dongosolo komanso chithandizo cha wodwala popanda kudziwitsa adokotala ndikosavomerezeka.

Komabe, pali njira zingapo zosinthira.

Glurenorm analogues:

Nthawi zambiri, mankhwalawa amakhala ndi chinthu chimodzi chomwe chimagwira ndi mtundu wina wowonjezera. Mlingo wa piritsi limodzi umatha kusiyana, zomwe ndikofunikira kuziganizira mukamachotsa Glyurenorm.

Ndikofunika kudziwa kuti pazifukwa zina, nthawi zina mankhwala ngati omwewo amakhala ndi magwiridwe osiyanasiyana ogwira ntchito. Izi zimachitika makamaka chifukwa cha mawonekedwe a kagayidwe kamunthu aliyense payekha komanso masinthidwe a kapangidwe ka mankhwala ochepetsa shuga. Mutha kuthetsa vuto lakusintha ndalama kokha ndi dokotala.

Mutha kugula Glyurenorm m'magawo azachikhalidwe komanso pa intaneti. Nthawi zina sizikhala pamasamba a akatswiri ogulitsa mankhwalawa, kotero odwala omwe ali ndi matenda a shuga a 2, omwe amathandizidwa kwambiri ndi mankhwalawa, amayesa kuyitanitsa kudzera pa World Wide Web.

Mwakutero, kulibe vuto lililonse kupeza Glurenorm, mtengo wake womwe umachokera ku 430 mpaka 550 rubles. Kukula kwa mayeso mu njira zambiri zimadalira kokhazikika kwa wopanga komanso mawonekedwe amomwe amapangira mankhwala. Nthawi zambiri, madokotala enieniwo amatha kuuza wodwala kumene angapeze mapiritsi ochepetsa shuga.

Ndemanga Zahudwala

Odwala omwe akutenga Glurenorm, omwe ndemanga zawo ndizosavuta kupeza pa intaneti, nthawi zambiri amakhala ndi mankhwala okwanira.

Komabe, ndikofunikira kuti mumvetsetse kuti chida ichi sichinthu chopezeka pagulu komanso chosangalatsa. Imagulitsidwa (nthawi yayitali) kokha ndi mankhwala ndipo imapangidwira chithandizo chachikulu cha matenda oopsa.

Chifukwa chake, mukamawerenga ndemanga pa intaneti, nthawi zonse muyenera kufunsa dokotala mofanananira. Glyurenorm itha kukhala yothandiza kwa odwala ena, koma yolakwika kwa ena.

Contraindication ndi zotsatira zosafunikira

Simungagwiritse ntchito Glurenorm pazinthu zotsatirazi:

1. Mtundu woyamba wa shuga. Zochitika za ketoacidosis.
2. Porphyria.
3. Lactase akusowa, galactosemia.
4. Kulephera kwamphamvu kwa chiwindi.
5. Kuchotsa koyambirira (kapangidwe kake) ka kapamba.
6. Nthawi ya bere ndi kuyamwa.
7. Pachimake matenda opatsirana m'thupi.
8. Kusalolera payekha.

Zotsatira zoyipa zomwe zimatsalira ndizotsalira:

• Kugona, kutopa, kugona tulo tosokoneza, mutu.
• Kuchepa kwa kuchuluka kwa leukocytes ndi mapulateleti m'magazi.
• Kusanza, m'mimba kusokonezeka, kusayenda kwa ndulu, kuchepa kwamatenda, kusanza.
• Kuchuluka kwa magazi m'magazi a shuga (hypoglycemia).
• Khungu limawonetsa khungu.

Kudzipatsa nokha mankhwala ndi Glenororm kumatsutsana. Kusankhidwa kwa Mlingo ndi regimen kumachitika kokha ndi adokotala.

Malangizo & zidule

Kwa odwala omwe ali ndi vuto la chiwindi

Mukamagwiritsa ntchito mankhwala oposa 75 mg kwa odwala omwe ali ndi vuto la chiwindi, kuyang'anira dokotala ndikofunikira. Glurenorm sayenera kumwedwa chifukwa cha kuwonongeka kwambiri kwa chiwindi, popeza 95% ya mankhwalawa imakonzedwa mu chiwindi ndikusiya thupi kudzera m'matumbo.

Kuphatikiza kwa mankhwala

Glurenorm imatha kukulitsa zotsatira za hypoglycemic ngati itengedwa chimodzimodzi ndi zoletsa za ACE, allopurinol, painkillers, chloramphenicol, clofibrate, clarithromycin, sulfanilamides, sulfinpyrazone, tetracyclines, cyclophosphamides omwe atengedwa pakamwa ndi mankhwala a hypoglycemic.

Pakhoza kukhala kufooka kwa zotsatira za hypoglycemic pankhani yogwiritsa ntchito glycidone ndi aminoglutethimide, sympathomimetics, glucagon, thiazide diuretics, phenothiazine, diazoxide, komanso mankhwala omwe amakhala ndi nicotinic acid.

Glyurenorm - malangizo, ntchito, mtengo, ndemanga

Glurenorm imagwiritsidwa ntchito nthawi zambiri pamene zakudya sizigwirizana ndi kukonzedwa kwa glycemia. Izi matenda amapezeka mu 90% ya odwala omwe ali ndi matenda ashuga, ndipo kuchuluka kwazomwe zikuwonetsa kuti chiwerengero cha odwala chotere chikukula.

Dzinalo Lopanda Padziko Lonse

Glycidone. (Mu Chilatini - Gliquidone).

Glurenorm imagwiritsidwa ntchito nthawi zambiri pamene zakudya sizigwirizana ndi kukonzedwa kwa glycemia.

Mapiritsi okhala ndi mawonekedwe osalala a 30 mg a glycidone, womwe ndi gawo lalikulu la mankhwala.

• sungunuka ndi wowuma wowuma wochokera ku chimanga,
• monohydrogenated lactose,
• magnesium wakuba.

Zotsatira za pharmacological

Glycvidone amadziwika ndi zowonjezera-pancreatic / pancreatic athari. Thupi limasintha kupanga insulini pochepetsa mphamvu ya glucose pama cell a pancreatic beta.

Kuphatikiza apo, mankhwalawa amakulitsa chiwopsezo cha insulin komanso kulumikizana ndi maselo ojambulidwa, kumawonjezera kukhudzika kwa shuga ndi mawonekedwe a chiwindi ndi minyewa ya minofu, ndikuchepetsa njira ya lipolytic mu minofu ya adipose.

Imakhala ndi ntchito ya hypolipidemic, imachepetsa mawonekedwe a m'magazi a m'magazi. Mphamvu ya hypoglycemic imatheka pambuyo pa maola 1-1,5.

Thupi limasintha kupanga insulini pochepetsa mphamvu ya glucose pama cell a pancreatic beta.

Momwe mungatenge glurenorm

Mkati, mogwirizana ndi malangizo a dokotala zokhudzana ndi kuchuluka kwa mankhwalawa, kutalika kwa mankhwala ndikutsatira zakudya zomwe zasankhidwa.

Kumayambiriro kwa mankhwalawa, mapiritsi a 0,5 amatchulidwa pakudya m'mawa. Pokhapokha ngati pali kusintha, mlingo umachulukitsa pang'onopang'ono.

Ngati Mlingo watsiku ndi tsiku uposa mapiritsi awiri, ndiye kuti uyenera kugawidwa m'magawo awiri a 2-3, koma ndikofunikira kutenga gawo lalikulu la mankhwalawa m'mawa. Kwa tsiku limodzi ndikuletsedwa kumwa mapiritsi oposa anayi.

Pokhapokha pakuchitika pa monotherapy ndi mankhwalawa, kuphatikiza mankhwala kumayikidwa pamodzi ndi metformin.

Zotsatira zoyipa Glyurenorma

• kagayidwe: hypoglycemia,
• minofu ndi khungu: photosensitivity, zidzolo, kutupa,
• Masomphenya: mavuto okhala ndi malo okhala,
• Mimba thirakiti: kusapeza bwino pamimba, cholestasis, kusanza, kutsekula m'mimba, kudzimbidwa, kusowa chilimbikitso,
• CVS: hypotension, mtima ndi kulephera kwa mtima, angina pectoris, extrasystole,
• CNS: vertigo, kutopa, migraine, ulesi,
• hematopoietic dongosolo: agranulocytosis, leukopenia.

Zokhudza mphamvu pakuwongolera njira

Odwala omwe amalandila MP akuyenera kudziwitsidwa za kuwopsa kwa chizungulire komanso kupweteka kwa mutu panthawi imeneyi. Chifukwa chake, ayenera kukhala atcheru poyendetsa galimoto ndikugwira ntchito yozama.

Odwala omwe amalandila MP akuyenera kudziwitsidwa za kuwopsa kwa chizungulire komanso kupweteka kwa mutu panthawi imeneyi.

Gwiritsani ntchito pa nthawi yoyembekezera

Palibe chidziwitso pakugwiritsa ntchito glycidone mwa amayi apakati / oyembekezera, motero MP sigwiritsidwa ntchito pano.

Pokonzekera kutenga pakati, ndikofunikira kusiya mankhwala ndikugwiritsanso ntchito insulin kukonza shuga.

5% yokha ya MP imachotsedwa kudzera mu impso, kotero palibe zotsutsana pamenepa.
5% yokha ya MP imachotsedwa kudzera mu impso, kotero palibe zotsutsana pamenepa.

Wopanga

Kampani yachi Greek "Boehringer Ingelheim Ellas".

Glurenorm - mankhwala ochepetsa shuga a impso odwala

Darina Bezrukova (wochiritsa), wazaka 38, Arkhangelsk

Mankhwala ndi mankhwala limodzi ndi mtundu wa 2 matenda a shuga. Pankhaniyi, wodwalayo ayenera kutsatira zakudya zapadera. Shuga amawongolera moyenera komanso moyenera.

Andrey Tyurin (wochiritsa), wazaka 43, Moscow

Ndikulembera matenda ashuga. Mapiritsi ndiwotsika mtengo, amasintha mkhalidwe wawo mwachangu. Nthawi yomweyo, ndikosayenera kuti amayi apakati azitha kugwiritsa ntchito mankhwalawa. Ndimawapatsa majakisoni a insulin.

M'mafakitala, mapiritsi amatchulidwa.

Anthu odwala matenda ashuga

Valeria Starozhilova, wazaka 41, Vladimir

Ndikudwala matenda ashuga, mankhwalawa amalandiridwa kwaulere. Adotolo adalowa m'malo mwa Diabeteson, ndipo ndidayamba kudwala. Anaona kwa mwezi. Shuga amasungidwa bwino, koma zovuta zomwe ndimakumana nazo zimandipezekabe.

Pakamwa pakamwa pawo panali pataletseka tulo, tulo tinasokonezeka, ndipo mutu unayamba kumva. Kenako adayamba kuvutika kugaya chakudya. Mawonekedwe olakwika adasowa patatha milungu 1.5 atangomaliza kumwa mapiritsiwo.

Zizindikiro zake zinakhala zabwinobwino, zinthu zinasintha.

Alexey Barinov, wazaka 38, Moscow

Ndili wachinyamata, sindinadyepo mokwanira komanso kumwa mowa kwambiri. Tsopano ndikuvomereza kuti matenda ashuga adayamba kudzipweteka. Ndidayesa kuthandizidwa ndimnjira zosiyanasiyana. Posachedwa, adotolo andipatsa mankhwalawa.

Ziwopsezo poyamba zimayamba kuoneka kochepa kwambiri, ndipo patatha milungu iwiri ndi iwiri mpaka itatha amisala anatha. Malotowo anabwerera kwawamba, kusuntha kunayamba, thukuta linasowa. Dotolo adati zisonyezo zanga zamankhwala zakhala bwino.

Glurenorm kwa odwala matenda ashuga - malangizo ndi malingaliro a anthu odwala matenda ashuga

Mmodzi mwa oimira gulu lalikulu la sulfonylurea derivatives (PSM) ndi kukonzekeretsa pakamwa Glurenorm. Pulogalamu yake yogwira, glycidone, imakhala ndi hypoglycemic, ikuwonetsedwa ngati matenda a shuga a 2.

Ngakhale kutchuka kwake kocheperako, Glurenorm ndiyothandiza kwambiri ngati gulu lawo. Mankhwalawa sachotsa impso, chifukwa chake amagwiritsidwa ntchito kwambiri mu matenda ashuga a nephropathy okhala ndi kulephera kwa impso.

Glurenorm imamasulidwa ndi gawo lachi Greek la kampani yopanga mankhwala yaku Germany Beringer Ingelheim.

Glurenorm mfundo ntchito

Glurenorm ndi a m'badwo wachiwiri wa PSM. Mankhwala ali ndi mitundu yonse yamankhwala amtundu wa gulu lino la hypoglycemic wothandizira:

1. Chofunika kwambiri ndicho pancreatic. Glycvidone, mankhwala othandizira omwe amapezeka m'mapiritsi a Glurenorm, amamangiriza ma cell a pancreatic cell ndikulimbikitsanso kuphatikiza kwa insulin mwa iwo. Kuwonjezeka kwa kuchuluka kwa mahomoni awa m'magazi kumathandizira kuthana ndi insulin, komanso kumathandizira kuchotsa shuga m'mitsempha yamagazi.
2. Chochita chowonjezerapo ndi extrapancreatic. Glurenorm imakulitsa chidwi cha insulin, imachepetsa kutulutsa shuga m'magazi. Matenda a shuga a Mtundu Wachiwiri amadziwika ndi zonyansa zomwe zimapezeka mu lipid mbiri yamagazi. Glurenorm imathandizira kusintha zizindikiritso izi, zimalepheretsa thrombosis.

Mapiritsi amachita pa gawo 2 la insulin kaphatikizidwe, kotero shuga amatha kukweza nthawi yoyamba mukatha kudya. Malinga ndi malangizo, mphamvu ya mankhwalawa imayamba patatha pafupifupi ola limodzi, mphamvu kwambiri, kapena nsonga, imawonedwa patatha maola 2,5. Kutalika konse kwa kuchitako kumafika maola 12.

Moni Dzina langa ndine Galina ndipo sindilinso ndi matenda ashuga! Zinanditengera milungu itatu yokhakubwezeretsa shuga kwachikhalidwe komanso kusakhala mankhwala osathandiza
>>Mutha kuwerenga nkhani yanga apa.

Ma PSM onse amakono, kuphatikiza Glurenorm, ali ndi vuto lalikulu: amathandizira kapangidwe ka insulin, mosasamala kanthu za kuchuluka kwa shuga m'matumbo a odwala matenda ashuga, ndiye kuti amagwira ntchito ndi hyperglycemia ndi shuga wabwinobwino. Ngati pali shuga wocheperako kuposa momwe amagwiritsidwira ntchito m'magazi, kapena ngati adagwiritsidwa ntchito pantchito ya minofu, hypoglycemia imayamba. Malinga ndi ndemanga ya odwala matenda ashuga, chiwopsezo chake ndichopambana kwambiri pakukonzekera kwa mankhwalawo komanso kupsinjika kwanthawi yayitali.

Pamene Glurenorm sangathe kumwa

Malangizo ogwiritsira ntchito aletse kutenga Glurenorm ya matenda ashuga pazotsatirazi:

1. Ngati wodwala alibe maselo a beta. Choyambitsa chimatha kukhala pancreatic resection kapena mtundu 1 shuga.
2. Woopsa matenda a chiwindi, hepatic porphyria, glycidone akhoza zimapukusidwa mosakwanira ndi kudziunjikira mu thupi, zomwe zimabweretsa bongo.
3. Ndi hyperglycemia, olemedwa ndi ketoacidosis ndi zovuta zake - makomedwe ndi kukomoka.
4. Ngati wodwala ali ndi hypersensitivity kuti glycvidone kapena PSM ina.
5. Ndi hypoglycemia, mankhwalawa sangathe kuledzera mpaka shuga atasinthidwa.
6. M'mikhalidwe yovuta kwambiri (matenda oopsa, kuvulala, maopaleshoni), glurenorm imasinthidwa kwakanthawi ndi insulin.
7. Pa nthawi yoyembekezera komanso nthawi ya hepatitis B, mankhwalawa amaletsedwa, chifukwa glycidone imalowa m'magazi a mwana ndikuwononga bwino chitukuko chake.

Pa nthawi ya malungo, shuga m'magazi amadzuka. Njira zochizira nthawi zambiri zimakhala ndi hypoglycemia. Pakadali pano, muyenera kutenga Glurenorm mosamala, nthawi zambiri mumayeza glycemia.

Matenda a mahomoni okhala ndi matenda a chithokomiro amatha kusintha ntchito ya insulin. Odwala oterewa amawonetsedwa mankhwala osayambitsa hypoglycemia - metformin, glyptins, acarbose.

Kugwiritsa ntchito mankhwala Glurenorm mu zakumwa zoledzeretsa kumadzaza ndi kuledzera kwambiri, kosadumphira mu glycemia.

Malamulo Ovomerezeka

Glurenorm imangopezeka mu gawo la 30 mg. Mapiritsiwo ndiwowopsa, motero amatha kugawidwa kuti apeze theka.

Mankhwalawa aledzera mwina asanadye, kapena kumayambiriro kwake. Izi zikachitika, pofika kumapeto kwa chakudyacho kapena pambuyo pake, kuchuluka kwa insulin kumawonjezeka ndi 40%, zomwe zimapangitsa kutsika kwa shuga.

Kutsika kwotsatira kwa insulin mukamagwiritsa ntchito Glyurenorm kuyandikira kwambiri m'thupi, chifukwa chake chiopsezo cha hypoglycemia ndi chotsika. Malangizowa akuyenera kuyamba ndi theka la piritsi pa kadzutsa.

Kenako mlingo umakulitsidwa pang'onopang'ono mpaka kubwezeredwa kwa shuga. Pazotheka pakati pakusintha kwa mlingo uyenera kukhala wosachepera masiku atatu.

Ndikofunikira kwambiri: Lekani kudyetsa mafia azakudya nthawi zonse. Ma Endocrinologists amatipangitsa kuti tiziwonongeratu ndalama pamapiritsi pomwe shuga m'magazi amatha kukhala ngati ma ruble 147 ... >>werengani nkhani ya Alla Viktorovna

Osadumpha chakudya mutatha kumwa mankhwalawa. Zogulitsa ziyenera kukhala ndi chakudya chamagulu, makamaka ndi otsika glycemic index.

Kugwiritsa ntchito Glenrenorm sikuchotsa zakudya zomwe zidaperekedwa kale komanso masewera olimbitsa thupi.

Ndi kumwa kosalekeza kwa zakudya zamafuta ndi ntchito zochepa, mankhwalawa sangaperekenso chindapusa cha odwala ambiri.

Kulandila kwa Glyurenorm ndi nephropathy

Kusintha kwa mlingo wa gluluorm wa matenda a impso sikofunikira. Popeza glycidone imadutsa kwambiri impso, odwala matenda ashuga omwe ali ndi nephropathy samachulukitsa chiopsezo cha hypoglycemia, monga mankhwala ena onse.

Zambiri pazomwe zikuwonetsa kuti pakatha milungu inayi yogwiritsa ntchito mankhwalawa, proteinuria imachepa ndipo kuyambiranso kwamikodzo kumayendera limodzi ndi kuwongolera kwa matenda ashuga. Malinga ndi ndemanga, Glurenorm imatchulidwa ngakhale pambuyo pothana ndi impso.

Gwiritsani ntchito matenda a chiwindi

Malangizowa amaletsa kutenga Glurenorm mu chiwindi kwambiri. Komabe, pali umboni wosonyeza kuti glycidone metabolism mu matenda a chiwindi imasungidwa nthawi zambiri, pomwe kuwonongeka kwa ziwalo sikumachitika, pafupipafupi zotsatira zoyipa sizikula. Chifukwa chake, kuikidwa kwa Glyurenorm kwa odwala otere ndikotheka ndikuwunika kokwanira.

Zotsatira zoyipa, zotsatira za bongo

Pafupipafupi pazinthu zosayenera mukamamwa mankhwala a Glurenorm:

Nthawi zina, panali kuphwanya kutulutsa kwa bile, urticaria, kuchepa kwa leukocytes ndi granulocytes m'magazi.

Pankhani ya bongo, chiopsezo cha hypoglycemia ndichachikulu. Chotsani ndi glucose wamkamwa kapena wamkati. Pambuyo pa kusintha kwa shuga, imatha kugwa mobwerezabwereza mpaka mankhwala atachotsedwa m'thupi.

Kuyanjana kwa mankhwala osokoneza bongo

Mphamvu ya Glenrenorm imatha kusinthika munthawi yomweyo ndimankhwala ena:

• njira zakulera pakamwa, zopatsirana mu CNS, mahomoni a chithokomiro komanso mahomoni a chithokomiro, nicotinic acid, chlorpromazine imafooketsa mphamvu yake
• ena NSAIDs, maantibayotiki, antidepressants, antimicrobials, coumarins (acenocoumarol, warfarin), thiazide okodzetsa, beta-blockers, Mowa umathandizira mphamvu ya mankhwalawa.

Mtengo ndi Glurenorm

Mtengo wa paketi wokhala ndi mapiritsi 60 a Glyurenorm ndi ma ruble 450. Glycidon ya mankhwala sili m'gulu la mankhwalawa, motero sizingatheke kuti ipatsidwe kwaulere.

Analogue yathunthu yokhala ndi zinthu zomwezi ku Russia sichikupezeka. Tsopano njira yolembetsa ikuchitika chifukwa cha mankhwalawa Yuglin, wopanga Pharmasynthesis. Kufanana kwachilengedwe kwa Yuglin ndi Glyurenorm kwatsimikiziridwa kale, chifukwa chake, tingayembekezere mawonekedwe ake ogulitsa posachedwa.

Mwa anthu odwala matenda ashuga okhala ndi thanzi labwino, PSM iliyonse ikhoza kulowa Glurenorm. Ali ponseponse, chifukwa chake ndiosavuta kusankha mankhwala okwera mtengo. Mtengo wa chithandizo umayamba kuchokera ku ma ruble 200.

Pakulephera kwa impso, linagliptin imalimbikitsa. Izi zimagwira mu kapangidwe ka Trazhent ndi Gentadueto. Mtengo wa mapiritsi pamwezi wa mankhwala amachokera ku ma ruble 1600.

Kapangidwe ka mankhwalawo, kufotokozera, ma CD, mawonekedwe

Kodi kukonzekera kwa Glurenorm kumabweretsa mtundu wanji? Malangizo ogwiritsira ntchito amadziwitsa kuti malonda amtunduwu amapezeka mu mawonekedwe a mapiritsi oyera ndi osalala a mawonekedwe ozungulira, ali ndi notch komanso m'mphepete, komanso cholembedwa "57C" ndi logo ya kampani.

Gawo lalikulu la mankhwalawo lomwe limafunsidwa ndi glycidone.Amaphatikizanso wowuma chimanga wowuma, lactose monohydrate, mafuta wowuma a chimanga ndi magnesium stearate (mankhwala ena).

Glurenorm ya mankhwala (mapiritsi) imapitilira kugulitsa m'matumba a zidutswa 10, zomwe zimadzaza m'matakada.

Zotsatira za pharmacological

Kodi mankhwala a Glurenorm ndi ati? Malangizo ogwiritsira ntchito akuti awa ndi othandizira a hypoglycemic, omwe amachokera ku sulfonylurea (m'badwo wachiwiri). Amapangidwira pakamwa pokhapokha.

Mankhwala omwe amafunsidwa ali ndi zotsatira za extrapancreatic ndi pancreatic. Zimathandizira kubisalira kwa insulin ndipo imayendetsa njira ya shuga mkati mwa mapangidwe ake.

Kafukufuku wazinyama zowonetsa kuti mankhwala osokoneza bongo adawonetsa kuti mankhwalawa "Glyurenorm", malangizo omwe ali mkatoni, amatha kuchepetsa kukana kwa insulini mu minofu ya adipose komanso chiwindi cha wodwalayo. Izi zimachitika pogwiritsa ntchito makina a postreceptor, omwe amalumikizidwa ndi insulin, komanso kuwonjezeka kwa ma receptors ake.

Hypoglycemic zotsatira atatha kumwa mankhwalawa pambuyo 65-95 Mphindi. Zambiri za kuchuluka kwa mankhwalawa, zimachitika pambuyo pa maola pafupifupi 2-3 ndipo zimatha pafupifupi maola 8-10.

Katundu wa Kinetic

Malangizo ogwiritsira ntchito "Glyurenorm" akuti kugwiritsa ntchito limodzi muyezo wa mankhwalawa (15-30 mg) kumathandizira kuyamwa kwake mwachangu komanso kwathunthu kuchokera m'mimba yotsekemera (pafupifupi 80-95%). Amafika pachimake pa ndende yake patatha maola awiri.

Chithandizo chogwira mankhwalawa chimakonda kwambiri mapuloteni a plasma.

Palibe zambiri pa gawo la glycidon kapena zotumphukira zake mwa placenta kapena BBB. Palibenso chidziwitso pazilowedwe za glycidone mkaka wa m'mawere.

Kodi kagayidwe kake ka mankhwala "Glyurenorm" kali kuti? Malangizo ogwiritsira ntchito akuti mankhwala omwe amafunsidwa amaphatikizidwa m'chiwindi kudzera mu demethylation ndi hydroxylation.

Kuchuluka kwa zochuluka za glycidone zimachokera m'matumbo. Hafu ya moyo wa mankhwalawa ndi maola 1-2.

Kwa odwala okalamba komanso azaka zapakati, magawo a kinetic a Glyurenorm ndi ofanana.

Malinga ndi akatswiri, kagayidwe ka mankhwalawa sikasintha mwa odwala omwe ali ndi vuto la chiwindi. Tiyeneranso kudziwa kuti odwala omwe ali ndi vuto laimpso, mankhwalawa sadziunjikira.

Zoletsa kumwa mankhwala

Ndi nthawi ziti zomwe zimalephereka kuti mupereke mapiritsi a Glurenorm? Malangizo ogwiritsira ntchito akuwonetsa zotsutsana zotsatirazi pamankhwala awa:

• Porphyria alternating pachimake,
• Mtundu woyamba wa shuga
• kulephera kwambiri kwa chiwindi,
• diabetesic acidosis, precoma, ketoacidosis ndi chikomokere,
• nthawi yapadera yapa kapamba,
• Matenda achilengedwe obadwa nawo monga galactosemia, tsankho lactose, kusowa kwa lactase ndi glugose-galactose malabsorption,
• zovuta za wodwala (mwachitsanzo, opaleshoni yayikulu, matenda opatsirana),
• nthawi yapakati
• zaka zazing'ono (chifukwa chosakwanira ndi chitetezo cha mankhwalawa mu gulu laka lino),
• nthawi yoyamwitsa
• Hypersensitivity kuti sulfonamides.

Mankhwala "Glurenorm": malangizo ogwiritsira ntchito

Mapiritsi a Glurenorm amadziwika okha mkati. Mukamamwa, muyenera kutsatira malangizo onse a dokotala pokhudzana ndi kuchuluka kwa mankhwalawa komanso zakudya. Ndi zoletsedwa kusiya kumwa mankhwalawo osakambirana kaye ndi katswiri.

Mlingo woyambirira wa mankhwala omwe amafunsidwa ndi mapiritsi 0,5 (i.e. 15 mg) pa kadzutsa koyamba. Mankhwalawa amayenera kumwedwa kumayambiriro kwa chakudyacho. Mukatha kudya, kudumpha zakudya ndizoletsedwa.

Ngati kugwiritsa ntchito piritsi la 1/2 sikubweretsa kusintha, ndiye mutatha kufunsa dokotala, mlingo wake umakulitsidwa pang'onopang'ono. Ngati muli ndi mapiritsi a tsiku lililonse a "Glyurenorm" osaposa 2 mapiritsi, akhoza kumwa kamodzi pakudya kadzutsa.

Ngati dokotala wakupatsani mitundu yayikulu ya mankhwalawa, ndiye kuti iyenera kugawa bwino pazigawo ziwiri kapena zitatu.

Kuchulukitsa mlingo wa mapiritsi opitilira anayi patsiku nthawi zambiri sikukula mphamvu zawo. Chifukwa chake, kumwa mankhwalawa "Glyurenorm" pazowonjezerazi sikulimbikitsidwa.

Kwa anthu omwe ali ndi vuto la impso, kusintha kwa mankhwalawa sikofunikira.

Kumwa mankhwala opitilira 75 mg mwa odwala omwe ali ndi vuto la chiwindi kumafuna kuwunika pafupipafupi ndi dokotala.

Ngati osakwanira achire kwenikweni, pamodzi ndi "Glurenorm" wodwala akhoza kupatsidwa "Metformin".

Milandu yambiri

Kutenga Mlingo wambiri wa mankhwala a sulfonylurea nthawi zambiri kumabweretsa hypoglycemia. Kuphatikiza apo, mankhwala osokoneza bongo amatha kuyambitsa zotsatirazi: thukuta, tachycardia, kusakwiya, njala, kupweteka kwa mutu, kugwedezeka, kunjenjemera, kusowa tulo, nkhawa zamagalimoto, kusawona bwino komanso kulankhula.

Zizindikiro za hypoglycemia zikawoneka, muyenera kudya glucose kapena zakudya zamafuta ambiri.

Zotsatira zoyipa

Tsopano mukudziwa chifukwa chake mankhwala monga Glurenorm amadziwika. Malangizo ogwiritsira ntchito mankhwalawa awunikiranso pamwambapa.

Malinga ndi odwala, mukumwa mankhwalawa, mutha kukumana:

• thrombocytopenia, angina pectoris, agranulocytosis,
• paresthesia, hypoglycemia, chizungulire,
• leukopenia, mutu, kugona kunja, kugona.
• zosokoneza malo, kutopa, hypotension,
• kulephera kwamtima, pakamwa pouma, matenda a Stevens-Johnson,
• kudya kwakachepa, kusowa kwa photosensitivity, nseru, zotupa,
• urticaria, kusanza, kupweteka pachifuwa, cholestasis,
• kudzimbidwa, kuyabwa kwa khungu, kutsekula m'mimba, kusapeza bwino pamimba.

Malangizo apadera

Hypoglycemic wothandizira pakamwa sayenera kulowa m'malo mwa chithandizo chamankhwala.

Anthu omwe ali ndi matenda ashuga ayenera kutsatira mosamalitsa malingaliro onse a dokotala.

Zizindikiro za hypoglycemia zikawoneka, muyenera kudya nthawi yomweyo zakudya zomwe zimakhala ndi shuga.

Zochita zolimbitsa thupi zitha kupititsa patsogolo zotsatira za hypoglycemic.

Chifukwa chakuti kuwonongeka kwa glycidone ndi impso ndi kofunikira, mankhwalawa atha kufotokozedwa mosamala kwa odwala omwe ali ndi vuto la impso, komanso matenda a shuga.

M'maphunziro azachipatala, zidapezeka kuti kugwiritsidwa ntchito kwa mankhwalawa kwa miyezi 30 sikunathandizenso kuwonjezeka kwa odwala. Kuphatikiza apo, pakhala pali milandu yochepetsa thupi ndi 1-2 kg.

Analogs ndi ndemanga

Mankhwala otsatirawa amatchulidwa kwa ma Glurenorm analogues: Gliklada, Amiks, Glianov, Glayri, Glibetik.

Ndemanga za mankhwala omwe amafunsidwa atha kupezeka mosiyanasiyana. Malinga ndi malipoti a ogula, mankhwalawa ndi othandiza kwambiri komanso opezeka kwa aliyense. Komabe, ziyenera kudziwidwa kuti odwala ambiri ali ndi nkhawa kwambiri chifukwa cha mndandanda wazotsatira zamtunduwu. Ngakhale madotolo amati ndi osowa kwambiri komanso nthawi zina.