Mndandanda wa mankhwala rosuvastatin ovomerezeka

The fanizo la mankhwala a rosuvastatin canon amaperekedwa, kukonzekera kosinthika kokhudza thupi, komwe kumakhala chinthu chimodzi kapena zingapo zofanana. Mukamasankha mawu ofananitsa, osangoganizira mtengo wawo, komanso dziko lakapangidwe ndi mbiri ya wopanga.

Kufotokozera za mankhwalawa
Mndandanda wazofananira ndi mitengo
Ndemanga
Malangizo ovomerezeka ogwiritsa ntchito

Kufotokozera za mankhwalawa

Rosuvastatin Canon - Mankhwala a hypolipidemic, osokoneza mpikisano wosankha wa HMG-CoA reductase, yemwe amasintha 3-hydroxy-3-methylglutaryl coenzyme A to mevalonate, cholesterol precursor.

Cholinga chachikulu cha ntchito ndi chiwindi, pomwe cholesterol synthesis ndi LDL catabolism zimachitika. Imaletsa ntchito ya HMG-CoA reductase (90% ya rosuvastatin imazungulira m'magazi). Kuchulukitsa kuchuluka kwa zolandirira za LDL pamtunda wa hepatocytes, kukulitsa kuchuluka ndi kutsimikizira kwa LDL, komwe kumayambitsa kulepheretsa kapangidwe ka VLDL, kuchepetsa chiwerengero chonse cha LDL ndi VLDL. Amachepetsa kuchuluka kwa cholesterol ya LDL, cholesterol yopanda HDL, cholembera wa VLDL, cholesterol yathunthu, triglycerides, triglycerides VLDL, apolipoprotein B (ApoV), kuchuluka kwa LDL cholesterol / LDL cholesterol / cholesterol, cholesterol, -HDL, ApoV / ApoA-1, imakulitsa kuchuluka kwa cholesterol ya HDL, ApoA-1.

The achire zotsatira amakula mkati 1 sabata pambuyo chiyambi cha mankhwala, pambuyo 2 milungu ukufika 90% ya okwanira zotheka, pazipita achire zotsatira zambiri zimatheka ndi 4 milungu mankhwala ndipo amakhala ndi ntchito pafupipafupi mankhwala.

Kugwiritsa ntchito odwala achikulire omwe ali ndi hypercholesterolemia, okhala ndi hypertriglyceridemia, osatengera mtundu, jenda kapena zaka) Odwala matenda a shuga ndi matenda am'magazi.

Mphamvu yowonjezera imawonedwa limodzi ndi fenofibrate (mogwirizana ndi kuchepetsa kuchuluka kwa triglycerides) ndi nicotinic acid mu lipid kutsitsa Mlingo (mogwirizana ndi kuchepetsa kuchuluka kwa HDL cholesterol).

Zizindikiro zogwiritsidwa ntchito

- Hypercholesterolemia ya pulayimale ya Fredraksen (mtundu IIa, kuphatikizapo heterozygous hypercholesterolemia) kapena hypercholesterolemia (mtundu IIb) monga chowonjezera pazakudya, pamene zakudya ndi zina zomwe siziri zovuta zamankhwala (zolimbitsa thupi, kuchepa thupi) sizokwanira.

- Family homozygous hypercholesterolemia monga njira yowonjezera pakudya ndi zina zam'mapapo zochepetsa (monga LDL apheresis), kapena ngati chithandizo chotere sichikugwira ntchito mokwanira.

- Hypertriglyceridemia (mtundu IV malinga ndi Fredricksen) monga chowonjezera pa chakudyacho.

- Kuti muchepetse kupita patsogolo kwa matenda a atherosulinosis monga chakudya chowonjezera mwa odwala omwe akuwonetsedwa kuti amachepetsa kuchuluka kwa cholesterol ndi LDL-C.

- Kuteteza koyambirira kwa mtima wamavuto amtundu wam'magazi (stroko, myocardial infarctionization, ochepa kusintha) mwa odwala akulu omwe ali ndi matenda am'mitsempha yamagazi, koma ali ndi chiopsezo chotukuka (zaka zopitilira 50 kwa amuna ndi zaka zopitilira 60 kwa akazi, kuchuluka kwa C-yogwira ntchito mapuloteni (opitilira 2 mg / l) pamaso pazinthu zina zowonjezera, monga kuwopsa kwa matenda oopsa, kuchuluka kwa cholesterol ya HDL, kusuta, mbiri ya banja yoyambirira kwamatenda a mtima.

Contraindication

Mapiritsi a 10 mg ndi 20 mg:

- kuchuluka kwa chidwi ndi rosuvastatin kapena chilichonse cha mankhwala,

- matenda a chiwindi pakatikati yogwira, kuphatikiza kuwonjezereka kwa ntchito ya serum transaminase ndi kuchuluka kulikonse kwa ntchito za seramu transaminase (zochulukirapo katatu poyerekeza ndi malire apamwamba)

Zowonongeka zamkati mwamphamvu (kulengedwa kwa clearinine chilolezo (CC) zosakwana 30 ml / min),

akazi: pakati, kuyamwa, kusowa kwa njira zakulera,

- Zokonzekera zomwe zimapangidwira kukula kwa zovuta zazikuluzikulu,

-Children osakwana zaka 18.

Mapiritsi 40 mg:

- kuchuluka kwa chidwi ndi rosuvastatin kapena chilichonse cha mankhwala,

akazi: pakati, kuyamwa, kusowa kwa njira zakulera,

odwala omwe ali pachiwopsezo chotenga myopathy / rhabdomyolysis, omwe ndi:

kulephera kwaimpso kwamphamvu kwambiri (CC zosakwana 60 ml / min),

- mbiri yaumwini kapena banja yodwala,

- myotoxicity mu odwala omwe amalandila mbiri ya HMG-CoA reductase inhibitors kapena ma fiber ena,

- kumwa kwambiri mowa,

-zikhalidwe zomwe zingayambitse kuchuluka kwa plasma ndende ya rosuvastatin,

- Kulandila munthawi yomweyo kwa ma fibrate,

-iwo oyambitsa mpikisano waku Asia,

-Children osakwana zaka 18.

Mapiritsi a 10 mg ndi 20 mg:

Kukhalapo kwa chiopsezo cha myopathy / rhabdomyolysis - kulephera kwa impso, hypothyroidism, mbiri yaumwini kapena banja yokhudza matenda obadwa nawo minofu ndi mbiri yakale yokhudza kupweteka kwa minofu ndi HMG-CoA reductase inhibitors kapena ma fiber, kudalira mowa, wopitilira zaka 65, mikhalidwe yomwe kuchuluka kumawonekera. kuchuluka kwa plasma ndende ya rosuvastatin, liwiro (mpikisano waku Asia - Japan ndi Chinese), munthawi yomweyo kugwiritsa ntchito mafupa, mbiri yakale ya matenda a chiwindi, sepsis, ochepa hypotension, opaleshoni yayikulu, zoopsa, kagayidwe kakang'ono, kusokonezeka kwa ma endocrine kapena ma elekitirodi, kapena kulanda kosalamulirika.

Mapiritsi 40 mg:

Kulephera kwa impso (CC oposa 60 ml / mphindi), kopitilira zaka 65, mbiri ya matenda a chiwindi, sepsis, hypotension, opaleshoni yayikulu, zoopsa, metabolic yayikulu, endocrine kapena kusokonekera kwa elekitirodi kapena kugwirira kosalamulirika.

Odwala omwe ali ndi vuto la chiwindi: palibenso data kapena chidziwitso chogwiritsa ntchito mankhwalawa kwa odwala omwe ali ndi mwayi wambiri kuposa 9 pamlingo wa Mwana-Pugh.

Gwiritsani ntchito pa nthawi yoyembekezera komanso nthawi yoyamwitsa: Rosuvastatin imayesedwa panthawi yapakati komanso mkaka wa m`mawere. Popeza cholesterol ndi zinthu zopangidwa kuchokera ku cholesterol ndizofunikira pakukula kwa fetus, chiopsezo cholepheretsa kuchepa kwa HMG-CoA kupitirira phindu logwiritsa ntchito mankhwalawa panthawi yapakati.

Ngati amayi apezeka ndi pakati pa mankhwala, mankhwalawa amayenera kuyimitsidwa nthawi yomweyo.

Amayi azaka zobereka azigwiritsa ntchito njira zokwanira zakulera.

Momwe mungagwiritsire ntchito: Mlingo ndi njira ya chithandizo

Mkati, piritsiyo siyenera kutafunidwa kapena kuphwanyidwa, kumeza lonse, kutsukidwa ndi madzi okwanira, imatha kutengedwa nthawi iliyonse masana, mosasamala kanthu za kudya. Ngati n`kofunika kumwa mankhwala muyezo wa 5 mg, piritsi limodzi ndi 10 mg ayenera kugawidwa.

Asanayambe chithandizo ndi Rosuvastatin Canon, wodwalayo ayenera kuyamba kutsatira zakudya zapamwamba za hypocholesterolemic ndikupitiliza kuzitsatira panthawi yamankhwala. Mlingo wa mankhwalawa amayenera kusankhidwa payekha kutengera zolinga zamankhwala komanso mayankho ochizira, pozindikira upangiri womwe ulipo pakulowera kwa lipid.

Mlingo woyambira wa odwala omwe ayamba kumwa mankhwalawa, kapena kwa odwala omwe atengedwa kuti atenge ma HMG-CoA reductase inhibitors, ayenera kukhala 5 mg (1/2 piritsi ya 10 mg) kapena 10 mg ya mankhwala kamodzi patsiku.

Ndi munthawi yomweyo makonzedwe a Rosuvastatin Canon omwe ali ndi gemfibrozil, michere, nicotinic acid womwe ndi gawo limodzi la 1 g / tsiku, gawo loyambirira la mankhwalawa ndi 5 mg (1/2 piritsi ya 10 mg).

Mukamasankha koyamba mlingo, munthu ayenera kutsogoleredwa ndi cholesterol imodzi ndikuwunika kuopsa kwa zovuta zamtima, komanso ndikofunikira kuwunika kuopsa kwa zotsatira zoyipa. Ngati ndi kotheka, mlingo utha kuwonjezeka pambuyo pa masabata anayi.

Chifukwa cha kutukuka kwa zoyipa mukamamwa mlingo wa 40 mg, poyerekeza ndi Mlingo wochepetsetsa wa 40 mg, pambuyo poti mlingo wowonjezera umakhala wokwera kuposa momwe mankhwalawa amathandizira milungu 4 kuchuluka kwa hypercholesterolemia ndi chiwopsezo chachikulu cha mtima (makamaka odwala omwe ali ndi hypercholesterolemia) omwe sanakwaniritse zotsatira zoyenera za mankhwala atamwa mlingo wa 20 mg, ndipo uyang'aniridwa ndi cha. Makamaka kuwunika mosamala odwala omwe akulandira mankhwalawa 40 mg akulimbikitsidwa.

Kugwiritsa ntchito mlingo wa 40 mg sikulimbikitsidwa kwa odwala omwe sanakumaneko ndi dokotala. Pambuyo pamankhwala a 2-4 milungu komanso / kapena ndi kuchuluka kwa mankhwalawa, kuwunika kwa metabolidi ya lipid ndikofunikira (ngati pakufunika kutero, kusintha kwa mlingo kumafunika).

Okalamba okalamba: kusintha kwa mankhwala sikofunikira.

Odwala omwe ali ndi vuto la aimpso wofatsa kapena pakati, kusintha sikofunikira. Kugwiritsa ntchito mitundu yonse ya mankhwalawa kupakidwa kwa odwala omwe ali ndi vuto laimpso (CC ochepera 30 ml / min). Kugwiritsa ntchito mankhwala muyezo wa 40 mg wolekerera odwala omwe ali ndi vuto laimpso (CC zosakwana 60 ml / min). Kwa odwala omwe ali ndi vuto laimpso lokwanira, koyamba mlingo wa 5 mg (1/2 piritsi 10 mg) umalimbikitsidwa.

Odwala ndi kulephera kwa chiwindi: rosuvastatin imaphatikizidwa kwa odwala omwe ali ndi matenda a chiwindi. Palibe zokuchitikirani ndi kugwiritsa ntchito mankhwalawa kwa odwala omwe ali ndi vuto la chiwindi pamwamba pa 9 pa sikelo ya Mwana-Pugh.

Mukamaphunzira ma paracokinetic magawo a rosuvastatin mwa anthu amitundu yosiyanasiyana, kuwonjezereka kwa ndende ya rosuvastatin pakati pa Japan ndi China kudadziwika. Izi zimayenera kukumbukiridwa mukamagwiritsa ntchito Rosuvastatin Canon pagulu la odwala. Mukamagwiritsa ntchito Mlingo wa 10 mg ndi 20 mg, mlingo woyenera wa odwala a ku Asia ndi 5 mg (1/2 piritsi ya 10 mg). Kugwiritsa ntchito mankhwala muyezo wa 40 mg ndi kovomerezeka kwa odwala amtundu waku Asia.

Odwala a Myopathy

Kugwiritsa ntchito mankhwala pa 40 mg ndi kutsutsana kwa odwala zomwe zimawonetsa kukonzekera kwa myopathy. Mukamagwiritsa ntchito Mlingo wa 10 mg ndi 20 mg, muyeso woyambira wa gulu ili la odwala ndi 5 mg (1/2 piritsi 10 mg).

Mukamagwiritsidwa ntchito ndi gemfibrozil, mlingo wa mankhwalawa suyenera kupitilira 10 mg / tsiku.

Zotsatira za pharmacological

Rosuvastatin Canon - mankhwala ochepetsa lipid, woletsa mpikisano wosankha wa HMG-CoA reductase. Kugwiritsa ntchito odwala achikulire omwe ali ndi hypercholesterolemia, kapena kapena osazindikira hypertriglyceridemia (osatengera mtundu, jenda kapena msinkhu), kuphatikiza pa odwala matenda a shuga komanso a hypercholesterolemia.

Mphamvu yowonjezera imawonedwa limodzi ndi fenofibrate (mogwirizana ndi kuchepa kwa ndende ya TG) ndi nicotinic acid mu lipid kutsitsa Mlingo (mogwirizana ndi kuchepa kwa kuchuluka kwa HDL-C).

Mitundu yotsika mtengo komanso m'malo mwa mankhwalawa rosuvastatin: mndandanda wamitengo

Rosuvastatin ndi mankhwala otchuka omwe amagwiritsidwa ntchito pochiza matenda a mtima.Chipangizocho chimachepetsa cholesterol mthupi ndipo chimachepetsa chiopsezo cha matenda a mtima. Zizindikiro za kumwa mankhwalawa zimaphatikizapo mitundu yonse ya hypercholesterolemia, dyslipidemia, atherosulinosis, myocardial infarction, ubongo, stroko.

Zomwe zimagwiritsidwa ntchito popanga mankhwala amtundu womwewo dzina lake ndi rosuvastatin. Izi ndi wothandizila hypolipidemic kuchokera pagulu la ma satins. Kutulutsa mawonekedwe - mapiritsi. Mankhwalawa sanatchulidwe kwa ana osakwana zaka 18, pa nthawi yoyembekezera, panthawi yobereka. Rosuvastatin imapangidwa ku Russia, komanso m'maiko ena a CIS komanso akunja.

Mtengo wapakati wa mankhwala ndi ma ruble 500-700, kutengera mlingo ndi kuchuluka kwa mapiritsi omwe ali phukusi. Mtengo wokwera wa mankhwalawo unapangitsa kusaka kwina kwa mankhwala otsika mtengo. Malo okhala pafupi ndi otchulira sikuti amakhala otsika mtengo nthawi zonse, koma ena alibe zotsutsana mofananamo kapena akupezeka kudera linalake.

Ngati dokotala watumiza rosuvastatin, ma analogu ndi otsika mtengo kuposa mankhwalawa ayenera kupezeka mwa mankhwala ochokera kwa wopanga antchito.

Dzina lamankhwala	Mtengo wapakati mum ruble	Feature
Akorta	550–880	Mankhwalawa amalembera hypercholesterolemia yoyamba monga Fredricksen, hyperglyceridemia, kuti achepetse kukula kwa atherosulinosis, kuti muchepetse kukula kwa matenda ofala ndi mtima.
Mertenil	450–1750	Mankhwala amapatsidwa dyslipidemic zinthu, ndi hypercholesterolemia. Kumwa mankhwala kuyenera kuphatikizidwa ndi zakudya zoyenera. Mapiritsi amatengedwa pakamwa, ngakhale zakudya, zimatsukidwa ndi madzi.
Rosuvastatin Canon	400–710	Mphamvu ya lipid yotsitsa lipid ndikuchepetsa cholesterol yonse. Analogue yabwino yotsika mtengo kwambiri yopanga ku Russia.

M'malo mwa Ukraine

Ganizirani zamtengo wotsika mtengo wa mankhwala opangidwa ku Ukraine. Mndandandandawu uli ndi mtengo wofananira komanso mafotokozedwe achidule a mankhwalawo.

Atorvacor. Mapiritsi okhala ndi atorvastatin monga mankhwala othandizira. Imagwira ntchito yoletsa kukhathamiritsa kuchuluka kwa cholesterol ndi lipoprotein m'madzi a m'magazi, ndikuchita zake mu chiwindi cha wodwalayo. N`zotheka kupereka mankhwala kwa ana pambuyo 10 chilimwe ndi achibale heterozygous hypercholesterolemia monga chowonjezera chachikulu chakudya. Mtengo wapakati ndi ma ruble 140-220.
Vasostat. Mankhwala ochepetsa lipid, chinthu chomwe chimagwira ndi simvastatin, chomwe chimakhudza kagayidwe ka lipid m'thupi. Imwani mankhwalawa pakamwa. Kusankhidwa ndi contraindicated vuto la chiwindi kulephera. Mtengo wapakati ndi ma ruble 110-180.
Lovastatin. Chidacho chimachotsa hyperlipoproteinemia, chimathandizira kusintha kaphatikizidwe ka cholesterol m'chiwindi cha wodwalayo. Mankhwalawa amachepetsa apolipoprotein B ndi triglycerides. Kusakhazikika kwa mankhwala ndi mankhwalawa kumachitika pakatha masiku 14 chiyambire kumwa mapiritsi. Gawo lalikulu ndi lovastatin. Sichikudziwika pa nthawi ya mimba komanso mkaka wa m'mawere. Mtengo wapakati ndi ma ruble 155-70 pa paketi 30 yamapiritsi.

Zojambula zaku Belarusi

Gome ili pansipa lili ndi mitengo yotsika mtengo ya Belarusi ya rosuvastatin, yomwe ithandiza kuthana ndi vuto lakusintha kwa mankhwalawo.

Dzina lamankhwala	Mtengo wapakati mum ruble	Feature
Rosutatin	210–550	Mankhwalawa ali m'mapiritsi okhala ndi rosuvastatin monga chinthu chogwira ntchito. Ili ndi zisonyezo zakugwiritsira ntchito kofanana ndi woyeserera. Mankhwalawa ali ndi zotsutsana zingapo.
Atorvastatin	120–600	M'malo otsika mtengo kwambiri a rosuvastatin. Chida chimenecho ndi cha gulu la mankhwalawa opatsirana ndi lipid ndipo amadziwika kuti amathandizira pazikhalidwe zomwe zimagwirizana ndi kuchuluka kwa mafuta m'thupi. Mankhwalawa sanalembedwe pa nthawi yoyembekezera, kuyamwa, komanso ana osaposa zaka 18.
Lipromak LF	135–550	Zomwe zimagwiritsidwa ntchito mu mankhwala ndi atorvastatin. Amachepetsa mulingo wa lipoprotein m'magazi. Mankhwalawa amayamba kugwira ntchito mwamphamvu m'chiwindi cha wodwalayo, chifukwa ndi pano momwe kuphatikizira kwa cholesterol kumachitika.Kugwiritsa ntchito ana kumatheka muyezo wosaposa 20 mg.

Zofanizira zina zakunja

Maimidwe ophatikizika amakono ndiokwera mtengo kwambiri ndipo alibe ntchito yocheperako:

Crestor. Analog yachilendo ya rosuvastatin, yomwe imapezeka pamapiritsi. Mankhwala otchuka ochepetsa lipid. Mankhwalawa amapangidwa ku UK, Puerto Rico. Mtengo wapakati ndi ma ruble a 515-55900.
Mertenil. Kuphatikizika kwa mankhwalawa kumaphatikizapo rosuvastatin monga chogwiritsa ntchito. Amachepetsa kuchuluka kwa cholesterol yambiri mthupi. Dziko loyambira - Hungary. Mtengo wapakati ndi ma ruble 510-1700.
Rosistark. Mankhwala ochokera ku gulu la mankhwala. Amagwiritsidwa ntchito pochiza hypercholesterolemia mwa odwala achikulire kuposa zaka 18. Kupezeka ku Croatia. Mtengo wapakati ndi ma ruble 250-790.

Mitundu yonse ya rosuvastatin, komanso mawonekedwe ake ndi zotengera zina, zimayimiriridwa m'mafakitima m'mizinda yaku Russia.

Muyenera kulabadirakuti, popeza yasankha kukondera mankhwala enaake, iyenera kumwa pafupipafupi, osalola kuti mankhwala ena athetse. Ichi ndichifukwa chake kuikidwa komaliza kumayenera kuchitika ndi dokotala woyenera yemwe amatha kuyesa kuyesa kuopsa ndi zovuta zake.

Mapiritsi a Rosuvastatin Canon: malangizo ndi fanizo 10 ndi 20 mg

Rosuvastatin Canon ndi mankhwala okhala ndi milomo yotsitsa lipid. Mankhwala ndi a gulu la ma statins.

Mankhwalawa ndi mpikisano wosankha wa HMG-CoA reductase, womwe umapangitsa kusintha kwa 3-hydroxy-3-methylglutaryl coenzyme A to mevalonate, yomwe imayang'anitsitsa cholesterol.

Cholinga chachikulu cha ntchito ya mankhwalawo ndi chiwindi, chiwalo chomwe chimagwira ntchito ya kapangidwe ka cholesterol ndi mphamvu ya lipoproteins yotsika.

Mankhwala tikulepheretsa ntchito ya HMG-CoA reductase. Mukamagwiritsa ntchito mankhwalawa, pafupifupi 90% ya rosuvastatin amayendayenda m'madzi a m'magazi.

Kugwiritsa ntchito mankhwalawa kumathandizira kukulitsa kuchuluka kwa zolandilira za LDL padziko nembanemba ya hepatocytes, yomwe imakulitsa kugwidwa ndi chidziwitso cha lipoproteins yotsika. Zotsatira zoterezi mthupi zimatsogolera kutsika kwa LDL mu plasma.

Zotsatira zakugwiritsidwa ntchito kwa mankhwalawa zimawonedwa kale sabata pambuyo poyambira mankhwalawa. Pambuyo milungu iwiri, achire zotsatira ukufika pazokwanira. Pambuyo pa nthawi imeneyi, kuchepa kwambiri kwa cholesterol m'thupi kumaonekera ndipo mwakugwiritsira ntchito mosalekeza mankhwalawa imasungidwa pamlingo wokulirapo kwanthawi yayitali.

Kugwiritsa ntchito mankhwalawa kumatha kuthandizira kuchepetsa thupi chifukwa kuchotsedwa kwa lipids zochuluka kuchokera pamenepo.

Kumasulidwa mawonekedwe ndi mankhwala

Wopanga amapanga mankhwalawo ngati mapiritsi. Pamwambapa mapiritsiwo amaphatikizidwa ndi zokutira filimu yofiyira.

Mawonekedwe ake ndi ozungulira, biconvex. Pamalo otsetsereka, chiwopsezo chimayikidwa. Pamtanda, kukonzekera kumakhala ndi mtundu woyera.

Chofunikira chachikulu pa mankhwala ndi calcium ya rauvastatin. Izi zili mgulu lofanana 10,4 mg, lomwe malinga ndi rosuvastatin koyera ndi 10 mg.

Kuphatikiza pazomwe zimagwira, zida zotsatirazi zamankhwala zimapezeka pakupanga kwa piritsi:

calcium hydrogen phosphate dihydrate,
wowuma chimanga
magnesium wakuba,
povidone
microcrystalline mapadi.

Kuphatikizika kwa kuphatikizika kwa mafilimu kumapiritsi kumaphatikizapo zinthu izi:

Selecoat AQ-01032 ofiira.
Hydroxypropyl methyl cellulose.
Macrogol-400.
Macrogol-6000.
Titanium dioxide
Varnish zotayidwa potengera utoto Ponso 4R.

Wopanga, mapiritsi opangidwa, amaika muma contour ma cell a PVC. Pamwamba paketiyo yokutidwa ndi zojambulazo.Phukusi lotere limasindikizidwa m'mabokosi amakatoni, momwe malangizo ogwiritsira ntchito mankhwalawa amaikidwira.

Mankhwala amapezeka pamapiritsi okhala ndi mitundu yosiyanasiyana ya mankhwala othandizira. Muzipatala, kutengera zosowa, mutha kugula mankhwala okhala ndi mapiritsi a rauvastatin 10, 20 ndi 40 mg piritsi limodzi.

Mtengo wa mankhwalawa umatengera dera lomwe likugulitsidwa ku Russian Federation, kuchuluka kwa mankhwala othandizira popanga mankhwala ndi kuchuluka kwa mapiritsi amodzi phukusi limodzi.

Mtengo wa phukusi limodzi, kutengera magawo omwe afotokozedwawo, umatha kuchoka pa 350 mpaka 850 rubles.

Wodwala amatha kugula mankhwalawo pokhapokha ngati pali mtundu wina wa madokotala omwe akupezeka.

Mankhwalawa amayenera kusungidwa pa kutentha osapitirira 25 digiri Celsius m'malo owuma osapezekanso kwa ana ndi ziweto. Malo osungirako ayenera kutetezedwa ku dzuwa. Alumali moyo wa mankhwala ndi zaka ziwiri.

Nthawi imeneyi, kugwiritsa ntchito mankhwalawo kuletsedwa, kuyenera kutayidwa.

Zizindikiro ndi contraindication kuti mugwiritse ntchito

Musanagwiritse ntchito mankhwala a Rosuvastatin Canon, muyenera kuphunzira mosamala malangizo ogwiritsira ntchito, kuwunikira zamankhwala ndi madokotala ndi odwala, ndikuzidziwa bwino mtengo wa mankhwalawo ndi mulingo wosiyanasiyana wa mankhwala othandizira.

Kuwongolera pakugwiritsa ntchito mankhwalawa kumalimbikitsa kumwa mankhwala pokhapokha atakambilana ndi dokotala.

Dokotalayo ndi amene amawona mulingo woyenera, poganizira zonse zomwe zikupezeka mthupi la wodwalayo.

Zizindikiro zazikulu pakugwiritsira ntchito mankhwalawa mogwirizana ndi malangizo omwe mungagwiritse ntchito ndi awa:

kukhalapo kwa hypercholesterolemia yoyamba malinga ndi Fredrickson (mtundu IIa, kuphatikizapo heterozygous hypercholesterolemia) kapena mankhwala osakanikirana a hypercholesterolemia (mtundu IIb) monga zowonjezera pazakudya, pazinthu izi kugwiritsa ntchito mankhwala osagwirizana ndi mankhwala (masewera olimbitsa thupi, kuchepa thupi) sikokwanira,
kupezeka kwa homozygous hypercholesterolemia, kuphatikiza pa zakudya ndi zina zam'magazi ochepetsa lipid (mwachitsanzo, LDL-apheresis), kapena ngati kugwiritsidwa ntchito kwa mankhwalawa sikugwira ntchito mokwanira,
kukhalapo kwa hypertriglyceridemia (mtundu IV malinga ndi Fredrickson) monga kuwonjezera pa zakudya zomwe mumagwiritsa ntchito.

Contraindication pakumwa mankhwala ali ndi kusiyana kutengera ndende ya mapiritsi a yogwira pophika.

Chifukwa chake mapiritsi okhala ndi 10 ndi 20 mg wa rosuvastatin, wodwalayo ali ndi zotsutsana zotsatirazi:

Matenda a chiwindi mu gawo logwira, komanso kuchuluka kwa transaminase.
Zowonongeka zazambiri za impso.
Kukhalapo kwa myopathy wodwala.
Kugwiritsa ntchito mankhwala a cyclosporin.
Nthawi ya bere ndi nthawi ya mkaka wa m'mawere.
Kukonzeratu zakutsogolo kwa zovuta za myotoxic.
Zaka zosakwana 18.
Hypersensitivity pamagawo a mankhwala.

Pogwiritsa ntchito mapiritsi omwe amakhala ndi rosuvastatin 40 mg, contraindication ogwiritsira ntchito ndi awa:

aimpso ndi chiwindi kulephera,
kubala ndi kuyamwitsa,
ntchito ndi cyclosporine,
kupezeka kwa matenda a chiwindi mu gawo lachitukuko,
kupezeka kwa thupi la kutchulidwa tsankho kwa zigawo za mankhwala.

Mankhwala osokoneza bongo omwe wodwala amakhala nawo akamatenga mitundu yambiri ya tsiku ndi tsiku.

Ngati bongo wapezeka, chithandizo chamankhwala chimayikidwa ndipo ntchito za chiwindi, komanso ntchito za CPK, zimayang'aniridwa.

Palibe mankhwala achindunji omwe amagwiritsidwa ntchito pakachitika bongo. Njira ya hemodialysis siyothandiza.

Malangizo ogwiritsira ntchito mankhwalawa

Mankhwala amaperekedwa pakamwa, nthawi iliyonse masana, mosasamala zakudya.

Piritsi liyenera kumezedwa lonse popanda kuphwanya, pomwe mukumwa uyenera kupita ndi kumwa madzi ambiri.

Pankhani yoika mankhwalawa muyezo wa 5 mg, piritsi lokhala ndi kuchuluka kwa gawo la 10 mg lingagawidwe pakati.

Asanayambe kuchita mankhwala ndi Rosuvastatin, Canon amafunika kuti wodwalayo azikhala ndi kudya kwa hypocholesterol kwakanthawi. Kugwirizana ndi zakudya zoterezi kumafunikanso mankhwala atangoyamba kumene.

Mlingo wa mapiritsi a cholesterol umasankhidwa ndi dokotala woganizira zotsatira za kusanthula ndi maphunziro a thupi la wodwalayo atatha kudya chakudya chamagulu ndi machitidwe ake.

Kuphatikiza apo, Mlingo wa mankhwala ogwiritsidwa ntchito ungakhudzidwe ndi cholinga cha njira yothandizira achire komanso chikhalidwe cha momwe thupi limayankhira pakugwiritsa ntchito Canon pochiza Rosuvastatin.

Malinga ndi malangizo ogwiritsira ntchito, mulingo woyenera wa mankhwalawa ndi 5 kapena 10 mg kamodzi patsiku.

Pogwiritsa ntchito munthawi yomweyo rosuvastatin wokhala ndi michere kapena nicotinic acid wokwanira osaposa gramu imodzi patsiku, mlingo woyambirira ndi 5 mg kamodzi patsiku.

Mukamasankha mlingo, dokotala amayenera kutsogoleredwa ndi zotsatira za kuyeza kuchuluka kwa cholesterol m'thupi la wodwalayo ndikuwunika zomwe zingakhale ndi vuto la mtima. Kuphatikiza apo, katswiriyo ayenera kuganiziranso za ngozi zomwe zingachitike chifukwa chogwiritsa ntchito mankhwalawa munthawi ya mankhwala.

Ngati ndi kotheka, Mlingo wa mankhwala omwe amagwiritsidwa ntchito amasinthidwa masabata anayi alionse.

Kugwiritsa ntchito mlingo wa 40 mg kumachitika kokha mwa odwala omwe ali ndi vuto lalikulu la chitukuko cha hypercholesterolemia ndi pamaso pangozi yayikulu yovuta mu ntchito ya mtima wamagazi, komanso kupezeka kwa kuthamanga kwa magazi mwa wodwala. Pankhani yogwiritsa ntchito mlingo wovomerezeka wa mankhwalawa panthawi ya chithandizo, wodwalayo ayenera kuyang'aniridwa ndi adokotala.

Kugwiritsa ntchito mankhwala mu mulingo woyenera kumalowetsedwa kwa odwala omwe amadziwika kuti aimpso amalephera komanso kuwonongeka kwa aimpso.

Mwa gulu ili la odwala, mlingo womwe umalimbikitsa ndi 5 mg tsiku lililonse patsiku limodzi.

Zotsatira zoyipa ndi mawonekedwe a Rosuvastatin Canon

Pakukonzekera kugwiritsa ntchito mankhwalawa, mavuto amayamba kupezeka m'thupi la wodwalayo.

Kuchulukana kwa mavuto kumadalira mlingo womwe amagwiritsidwa ntchito komanso zomwe munthu akhudzidwa ndi thupi.

Kuchokera kumbali yamkatikati yamanjenje, kupweteka mutu, chizungulire, ndipo nthawi zina, vuto la kukumbukira limatha kuchitika.

Kuchokera m'mimba thirakiti mavuto amadziwika ndi kuwonekera kwa kudzimbidwa, nseru, m'mimba kupweteka, kawirikawiri, kukula kwa kapamba ndi jaundice.

Njira yothandizira kupuma imatha kuyankha mankhwalawa ndi mawonekedwe monga kutsokomola komanso kufupika kwa mpweya.

Kuchokera ku minculoskeletal system, kuoneka kwa myalgia ndikotheka. Myopathies ndipo, nthawi zina, arthralgia.

Kumbali ya kwamikodzo, mbali imodzi imatha kuchitika mwa proteinuria, zotumphukira edema, ndipo nthawi zina, hematuria.

Chifukwa chomwa mankhwalawa, wodwalayo amatha kuona zizindikiro za matenda a shuga 2.

Ngati vuto lakutenga thupi pakumwa mankhwalawo lapezeka, lingathe kuthandizidwa ndi dokotala wothandizapo ndi ma fanizo omwe alipo.

Mpaka pano, opanga mankhwala amapereka zoposa 10 mankhwala osiyanasiyana omwe ali fanizo la Rosuvastatin Canon.

Zida izi ndi:

Akorta,
Mertenil.
Rosart.
Rosistark.
Rosuvastatin Sotex.
Rosuvastatin SZ.
Rosulip.
Rosucard.
Roxer.
Rustor.
Tevastor

Mankhwalawa amathandizanso thupi, koma amakhala ndi kusiyana kwakukulu pamlingo, zomwe zimathandiza wodwala kusankha njira yoyenera kwambiri, yotsika mtengo komanso yothandizira kuchiritsa kwa thupi.

Mankhwala Rosuvastatin akufotokozedwa mu kanema munkhaniyi.

Sonyezani shuga yanu kapena sankhani jenda kuti muyimikize.

Rosuvastatin: analogi ndi mitengo

Nthawi zambiri, rosuvastatin ndi mankhwala osankha pakakhala zofunika kupereka mankhwala ochepetsa lipid. Komabe, pakhoza kukhala zifukwa zingapo pamene wodwala akuvutika kugula mankhwalawa:

Kuperewera kwa mankhwala mu chipatala cha komweko.
Mtengo wokwanira wa mankhwalawa, omwe angakhudze bajeti ya wodwalayo, popeza kuti mupeze njira yothandizira yofunikira, maphunzirowa amafunikira.

Mankhwala ambiri ali ndi analogi. Ndipo "Rosuvastatin", ngati mankhwala ofunikira kwambiri, pankhaniyi, palibe.

Ma Analogs ndi mankhwala omwe ali ofanana mu mankhwala oyamba, koma omwe amapangidwa ndi makampani opanga mankhwala kupatula omwe anali oyambitsa.

Mwanjira ina, ma fanizo a Rozuvastatin pamsika wamafuta ndi mankhwala onse omwe ali ndi mankhwala osokoneza bongo a rosuvastatin, koma amapangidwa ndi kampani ina kupatula kampani ya Japan ya Shionogi.

Ndizofunikira kudziwa kuti omwe amapanga mitundu yosiyanasiyana ya Rosuvastatin akhoza kusiyana, zomwe sizikhudza zochizira, koma ziyenera kukumbukiridwa chifukwa cha tsankho la munthu payekhapayekha.

Pansipa pali mndandanda wazifanizo zazikulu za Rosuvastatin, zomwe ngati zingafunike, zitha kusintha m'malo mwa mankhwala oyambirirawo. Komanso tebulo lofanizira la mtengo wa rosuvastatin wa opanga osiyanasiyana adzaperekedwa. Koma, choyamba, muyenera kupereka chidziwitso chachidule chazomwe zidayambika, kuti ogula azitha kuyerekezera zomwe zimasiyanitsa makamaka zoyambirira ndi zoyimira.

Mapangidwe a "Rosuvastatin"

Rosuvastatin ndi mankhwala ochokera pagulu lamankhwala othandiza kuchepetsa matenda a lipid, omwe ali m'gulu laling'ono la reductase inhibitors (yogwira zigawo za cholesterol). Chosakaniza chophatikizacho ndi rosuvastatin mu mawonekedwe amchere wamchere (i.e. Calcium rosuvastatin). Mndandanda wathunthu wa omwe amapeza mapiritsi oyambira:

Lactose monohydrate ndi shuga wamkaka womwe umasiyana ndi wamba lactose mwa kukhalapo kwa molekyulu yowonjezera yamadzi mu kapangidwe ka mankhwala. Kukhalapo kwa gawoli kumapangitsa kuti rosuvastatin isavutike kwa odwala omwe ali ndi lactose tsankho, kapena kuchepa kwa lactase.
MCC ndi cellcose ya microcrystalline, yomwe imatenga zinthu zambiri zomwe sizimagwira thupi la munthu. Imatenga ma poizoni ndi zinthu zina zovulaza kenako ndikuichotsa m'thupi m'njira yosasinthika, ndiye kuti, imathandiza kuchepetsa kuperewera kwa thupi. Ntchito yogwira poyizoni komanso kusakhazikika kwamatumbo ndi m'mimba. Othandizira angapo akulimbikitsidwa kuti azigwiritsa ntchito ngati njira yochepetsera chilala, chifukwa MSC imapereka kukhudzika kwa m'mimba.
Orthophosphate (calcium phosphate) - ndi mchere wovuta kupangidwa ndi orthophosphoric acid ndi calcium calcium. Imakhala ndi ntchito yophika kuphika ndipo imalimbikitsa kuyamwa bwino kwa rosuvastatin.
Magnesium stearate - ndi mchere wovuta kupangidwa ndi stearic acid ndi magnesium. Ndiwofunidwa ndi anthu pazinthu zamankhwala, zomwe zimachotsedwa m'thupi popanda kusinthidwa.
Crospovidone (matchulidwe amatha kuchitika: povidone, dzina linalo) ndi enterosorbent yotakata. Imatha kuyamwa zinthu zovulaza m'thupi (kuphatikiza zomwe zimapangidwa ndi zochita za rosuvastatin pa thupi la munthu).
Glyceryl triacetate (triacetin) ndizowonjezera chakudya zomwe zimalembedwa kuti E1518, zimaloledwa m'maiko ambiri padziko lapansi (makamaka, ku Russian Federation ndi mayiko a European Union) ndipo, kutengera kafukufuku wambiri, kumawoneka kuti ndi kotetezeka thupi la munthu. Popanga mankhwala opangira mankhwala amakhala ndi zovuta monga moisturizer, plasticizer ndi solvent.
Hypromellose (Hydroxypropyl methylcellulose) - imakhala ndi zoteteza.
Iron oxide - ndi chinthu chomwe chimachokera kuchikhalidwe, chomwe chimakhala ndi chitsulo ndi mpweya. Monga gawo la "Rosuvastatin" imagwiritsidwa ntchito ngati utoto.
Titanium dioxide (zinthu zotsatirazi zimapezekanso: titanium oxide IV, titanium yoyera) - utoto wa chakudya ndi chizindikiro E
Madzi oyeretsedwa.

Chifukwa chiyani muyenera kudziwa za fanizo la "Rosuvastatin"

Kutha kugula mankhwalawa pamtengo wabwino kwambiri. Nthawi zambiri, analogi imakhala yotsika mtengo. Izi sizikugwirizana ndi mtundu wa malonda, koma zitha kukhala chifukwa chochepetsera kutsatsa, mayendedwe ndi ndalama zina. Komanso, milandu yothandizirana pochiritsa akatswiri kapena makliniki omwe ali ndi makampani opanga ma pharmacological kapena ma cell a ma pharmacy sichinthu zachilendo, pomwe choyambirira chamtengo wapatali kapena chidule chingalembedwe kwa wodwala.
Kuthekera kwa kubwezeretsa rosuvastatin chifukwa cha mankhwala omwe sanatchulidwe mu mankhwala. Nthawi zambiri, ngakhale wazamankhwala sangathe kufotokozera zamankhwala, kapena kuyesera kugulitsa mapiritsi okwera mtengo kwambiri.

Mndandanda wa analogi of "Rosuvastatin"

Dzina lamankhwala Opanga Othandizira Odziwika pazinthu, kapena zina.

Crestor	ASTRAZENECA UK LTD (United States of America).	lactose monohydrate, mcc, stearate, calcium hydrogen phosphate, chitsulo okusayidi, hypromellose, titanium dioxide, crospovidone	palibe
Akorta	PJSC Pharmstandard-Tomskkhimfarm (Russian Federation)	chimodzimodzi monga "Crestor"	palibe
Mertenil	Gedeon Richter (waku Hungary)	chimodzimodzi monga "Crestor"	Mapiritsi okhala ndi mulingo woyenera wokhala ndi 0,5% ya rosuvastatin pa 5 mg iliyonse, ndiye kuti mapiritsi a 5 mg - zenizeni za rosuvastatin ndi 5.2 mg, mapiritsi a 10 mg - 10,4 mg ndi zina zotero.
Rosart	Gulu la Actavis (Iceland)	chimodzimodzi monga "Crestor"
Rosistark	Belupo (Croatia)	chikasu cha quinoline chimagwiritsidwa ntchito m'malo mwa iron oxide, ziwalo zina ndizofanana
Kalasi ya Rosuvastatin	MSN Laboratories Limited (India), Assia Chemical Industries Ltd (Israel) ndi ena	palibe	mankhwalawa sagulitsidwa kudzera m'makampani ogulitsa mankhwala, omwe kugula kochepa nthawi zambiri kumachokera ku 5 kg.
Rosuvastatin Canon	Canonfarm Production Osapindulitsa	m'malo mwa iron oxide, varnish ya aluminiyamu imagwiritsidwa ntchito ndipo seleroate yofiira imawonjezeredwa, zosakaniza zina ndizofanana ndi kapangidwe kazomwezo	ambiri ndemanga zabwino
Rosuvastatin-SZ	Makampani opanga mankhwala "North Star"	iron oxide imasinthidwanso ndi varnish ya aluminium ya mitundu itatu	palibe
Rosucard	Zentiva (Czech Republic)	croscarmellose imalowa m'malo mwa hypromellose kuchokera pazomwe zimapangidwira kale, ziwalo zina ndizofanana
Rosulip	EGIS Mankhwala PLC (Hungary)	zofanana ndi kapangidwe koyambirira
Roxer	KRKA (Slovenia)	Copolymers of butyl methacrylate ndi methylryacrylate adawonjezeredwa ndi chipolopolo
Tevastor	"TEVA Pharmaceutical Viwanda, Ltd" (Israel)	Zomwe zimapangidwazo zimaphatikizapo aluminium varnish ndi utoto wonyezimira wa dzuwa, zigawo zotsalazo ndizofanana ndi zomwe zimapangidwira (kuphatikizapo chitsulo oxide)

Mankhwala onse omwe ali pamwambawa ndi ma analogi a rosuvastatin, ndiye kuti, mankhwala omwe ali ndi chinthu chofanana. M'malo mwake, izi ndi zonse - mankhwala omwewo okhala ndi mayina osiyanasiyana ogulitsa ndikugulitsidwa pamitengo yamitundu yonse ndi yogulitsa (mtengo wotsatsa wamba udzaperekedwa pagome m'gawo lotsatira la kusindikiza). Palinso ma analogu osadziwika, ndiye kuti, mankhwala ochokera ku gulu limodzi la mankhwala (pano, reductase inhibitors) omwe ali ndi vuto lofananalo, koma ali ndi chinthu china chogwira ntchito. Mankhwalawa ndi ena osakhudzana ndipo amatha kutumizidwa ndi akatswiri pokhapokha malinga ndi data ya labotale.

Chithunzi chofananira cha mtengo wamafanizo a "Rosuvastatin"

Akorta	Mtengo: ma ruble 530
Mertenil	Mtengo: 500 ma ruble
Rosart	Mtengo: ma ruble 485
Rosistark	Mtengo: 450 rubles
Rosuvastatin Canon	Mtengo: 420 rubles
Rosuvastatin-SZ	Mtengo: 450 rubles
Rosucard	Mtengo: 590 rubles
Rosulip	Mtengo: 515 rubles
Roxer	Mtengo: ma ruble 540
Tevastor	Mtengo: 480 rubles

Pakuwona bwino kwa phunziroli, lochitidwa mokomera ogula mankhwalawo omwe akufunsidwa, mndandandandawo uli ndi zofananira pamtundu wotsatira ndi kuchuluka: 10 mg ya rosuvastatin pa piritsi, 30 mapiritsi amodzi. Njira iyi yakhazikitsire ndiyodziwika kwambiri pakati pa ogula, chifukwa chake ndikofunika kuperekera mankhwalawa mu maphunziro a pamwezi kuti mudziwe kuchuluka kwa kusintha kwa thupi la munthu ku rosuvastatin.

Mtengo wa "Rosuvastatin" komanso kuthekera kwakwe ndikusintha ndi analogues

Mu msika wogulitsa mankhwala "Rosuvastatin" mu mulingo wa 10 mg ndi kuchuluka kwa mapiritsi, zidutswa 30 zimagulitsidwa pamtengo kuchokera pa 380 mpaka 490 rubles, kutengera ndondomeko yamitengo ya wogulitsa ndi wogulitsa zamankhwala, komanso kutengera dera.

Chifukwa chake, nthawi zambiri, choyambirira cha Rosuvastatin ndi chotsika mtengo kuposa ma analogues ake, ndipo mukupangiratu kugula ma analogu pokhapokha ngati mankhwala oyambirirawa sanapezeke mu izi.

Kutengera ndi malingaliro omwe adayikidwa pagulu la anthu pa intaneti komanso pazosindikiza, titha kudziwa kuti ogula amakonda mankhwala oyamba.

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Mapiritsi 5 mg, 10 mg, 20 mg ndi 40 mg Rosuvastatin: malangizo, ndemanga ndi mitengo

Munkhani yachipatala iyi, mutha kudziwa za Rosuvastatin. Malangizo ogwiritsira ntchito akufotokozera momwe mapiritsi oponderezedwera angatenge, zomwe mankhwalawo amathandizira, ndi ziti zomwe zingagwiritsidwe ntchito, contraindication ndi mavuto. Chofotokozedwacho chimapereka mtundu wa mankhwalawa komanso mawonekedwe ake.

Munkhaniyi, madokotala ndi ogula amatha kusiya ndemanga zenizeni za Rosuvastatin, pomwe mungadziwe ngati mankhwalawo adathandizira pochiza hypercholesterolemia ndikuchepetsa cholesterol yamagazi mwa akulu ndi ana, omwe adawalembera. Malangizo amalemba mndandanda wa mankhwala a Rosuvastatin, mitengo ya mankhwalawo m'masitolo am'mimba, komanso momwe amagwiritsidwira ntchito panthawi yomwe ali ndi pakati.

Mankhwala ochepetsa lipid ndi rosuvastatin. Malangizo ogwiritsira ntchito akuwonetsa kuti mapiritsi a 5 mg, 10 mg, 20 mg ndi 40 mg m'munsi mafuta m'thupi, amathandizira zochizira hypercholesterolemia, komanso kupewa atherosulinosis.

Kutulutsa mawonekedwe ndi kapangidwe kake

Mankhwala Rosuvastatin amapangidwa mwanjira ya mapiritsi, mapiritsi okhala ndi mafilimu opanga pakamwa (pakamwa).

Ali ndi mtundu wa pinki kapena wapinki, wozungulira bwino komanso wamtundu wa biconvex.

Chofunikira chachikulu pa mankhwalawa ndi rosuvastatin, zomwe zili piritsi limodzi ndi 5, 10, 20 kapena 40 mg.Komanso, kapangidwe kake kamaphatikizapo zotuluka

Mapiritsi a Rosuvastatin amadzaza m'matumba a chithuza cha zidutswa 10. Phukusi la makatoni mumakhala mapaketi atatu kapena 6 otupa komanso malangizo ogwiritsira ntchito mankhwalawa.

Zotsatira zoyipa

Poyerekeza ndi kutenga mapiritsi a Rosuvastatin, kukula kwa zoyipa zamthupi kuchokera ku ziwalo zosiyanasiyana ndi kachitidwe ndikotheka:

Thupi lawo siligwirizana - zotupa pakhungu, kuyabwa kwake, ming'oma, kufanana ndi kuwotchera.
Kugaya chakudya - chizolowezi cha kudzimbidwa, kupweteka kwam'mimba, kupweteka pamimba, kuchepa kwa khunyu kwapang'onopang'ono (kapamba).
Mitsempha yamanjongo - samapezeka kawirikawiri mapuloteni (proteinuria) ndi magazi (hematuria) mkodzo.
Endocrine dongosolo - kukula kwa matenda a shuga a 2.
Musculoskeletal system - kupweteka kwa minofu (myalgia), kutupa (myositis) ndi chiwonongeko (rhabdomyolysis), makamaka mwa anthu omwe ali ndi vuto la myopathy.
Mitsempha yam'mimba - mutu, chizungulire chamkati, kufooka kwakukulu (asthenia).

Kukula kwa zotsatira zoyipa ndi chinthu chodalira mlingo. Pafupipafupi kuchuluka kwake ndi mankhwalawa 40 mg tsiku. Maonekedwe amachitidwe oyipa ndiye maziko osinthira kapena kusiya mankhwala.

Ana, pa mimba ndi mkaka wa m`mawere

Rosuvastatin amatsutsana panthawi yoyembekezera komanso panthawi yoyamwitsa. Amayi azaka zobereka azigwiritsa ntchito njira zokwanira zakulera. Popeza cholesterol ndi mankhwala ake a biosynthesis ndizofunikira pakukula kwa fetal, chiopsezo choletsa HMG-CoA reductase chimaposa phindu logwiritsa ntchito mankhwalawa amayi apakati.

Ngati muli ndi pakati pamankhwala, mankhwalawa amayenera kuyimitsidwa nthawi yomweyo. Palibe deta pakugawidwa kwa rosuvastatin mkaka wa m'mawere, chifukwa chake, panthawi yoyamwitsa, mankhwalawa ayenera kusiyidwa.

Malangizo apadera

Pogwiritsa ntchito mlingo waukulu wa rosuvastatin (nthawi zambiri 40 mg), proteinuria ya tubular imatha kuyang'aniridwa, yomwe nthawi zambiri imakhala yachilengedwe. Kuphwanya uku sikuwonetsa kuchuluka / kufalikira kwa matenda a impso.

Odwala omwe apeza mlingo waukulu wa mankhwalawa amalimbikitsidwa kuti azitsatira ntchito yaimpso. Kuti mupewe kupotoza zotsatira, osavomerezeka kudziwa ntchito ya creatine phosphokinase pambuyo pakuchita zolimbitsa thupi kapena pamaso pa zifukwa zina zowonjezera zomwe zikuchitika.

Ngati kumayambiriro kwa zamankhwala, ntchito yoyambirira ya creatine phosphokinase imakulitsidwa kwambiri (nthawi zopitilira 5), patatha masiku 5-7, muyeso wachiwiri uyenera kuchitidwa. Mukatsimikizira zizindikiro, chithandizo sichimayamba. Kuyamba kwadzidzidzi kwa kupweteka kwa minofu / kufooka kapena kupsinjika, makamaka kuphatikiza ndi malungo ndi malaise, kumafuna chithandizo chamankhwala.

Zikatero, ndikofunikira kudziwa ntchito ya creatine phosphokinase. Ngati zizindikirizo zikazimiririka, ndipo zizindikirazo zikubwerera mwakale, mutha kulingaliranso za Rosuvastatin pamiyeso yotsika moyang'anitsitsa momwe wodwalayo alili. Popeza kulibe zizindikiro, kuwunikira ntchito za creatine phosphokinase ndikosatheka.

Pali zambiri zokhudzana ndi zochitika zapafupipafupi za immune-mediated necrotizing myopathy zomwe zimachitika ndi mawonetseredwe azachipatala (kupitiriza kwa proximal minofu kufooka ndikuwonjezera ntchito ya serum creatine phosphokinase) munthawi yamankhwala kapena pamene Rosuvastatin amachotsedwa. Kuphatikiza apo, maphunziro a serological, kuwunika kwamanjenje ndi minyewa, komanso kugwiritsa ntchito mankhwala a immunosuppress kungafunike.

Mukamamwa mankhwala a Rosuvastatin ndi concomitant, zizindikiro za kuchuluka kwa minofu ya fupa sizimawonedwa.

Komabe, pali malipoti akuwonjezeka kwa zochitika za myopathy ndi myositis mwa odwala omwe amatenga zina za HMG-CoA reductase inhibitors kuphatikiza ndi zotumphukira za fibric acid, kuphatikiza

ndi gemfibrozil, cyclosporine, nicotinic acid mu lipid kutsitsa Mlingo (woposa 1000 mg patsiku), azole antifungal agents, HIV proteinase inhibitors ndi ma macrolide anti virus.

Ngati odwala chiwonetsero cha glucose ndi 5.6-6.9 mmol / L, mwayi wofanana ndi matenda a shuga 2 ukuwonjezeka. Kuchepetsa / kusiya kwa mankhwalawo kumasonyezedwa pokhapokha ngati ntchito ya hepatic transaminases mu seramu yamagazi ipitirira malire apamwamba abwinobwino nthawi 3 kapena kupitilira.

Ngati mukukayikira kukhazikika kwa matenda apamtundu wamatumbo (akuwonekera ngati kupuma movutikira, chifuwa chosabereka, kufooka, kuchepa thupi, kutentha thupi komanso thanzi labwino), Rosuvastatin imathetsedwa.

Chifukwa chakukula kwa kufooka ndi chizungulire, odwala ayenera kusamala nthawi ya chithandizo poyendetsa magalimoto.

Kuyanjana kwa mankhwala osokoneza bongo

Maantacidids amatha kumwa pokhapokha nthawi yayitali (pafupifupi maola awiri) mutamwa mankhwalawa, chifukwa kugwiritsa ntchito kwawo kumayambitsa kutsika kwa Rosuvastatin.

Erythromycin nayenso sayenera kumwedwa molumikizana ndi mankhwalawa, chifukwa mphamvu yothira mankhwalawa imachepa.

40 mg rosuvastatin molumikizana ndi fibrate amatsutsana. Gemfibrozil imawonjezera chiopsezo cha myopathy pamene imagwiritsidwa ntchito limodzi ndi HMG-CoA reductase inhibitors (kuphatikiza kosavomerezeka). Mukaphatikizidwa ndi micrate kapena lipid-kuchepetsa madontho a nicotinic acid, phindu limayenera kukhala loyenera mosamala ndi chiwopsezo.

Mndandanda wa mankhwala Rosuvastatin

Kapangidwe kamene kamayimira fanizo:

Tevastor
Akorta.
Kalasi ya Rosuvastatin.
Rosart.
Rosistark.
Rosuvastatin SZ.
Crestor.
Rosucard.
Rosulip.
Roxer.
Mertenil.
Suvardio.
Rosuvastatin Canon.
Rustor.

Gulu la statins limaphatikizapo ma analogues:

Leskol.
Pravastatin.
Tulip.
Rovacor.
Roxer.
Simvastol.
Cardiostatin.
Ator.
Torvazin.
Rosucard.
Lovasterol.
Leskol forte.
Lipostat.
Atherostat.
Zokor forte.
Lovacor.
Simvalimite.
Akorta.
Lipobay.
Rustor.
Torvas
Simvor.
Rosulip.
Apextatin.
Atorvox.
Rosart.
Torvacard.
Liprimar.
Lovastatin.
Crestor.
Machitidwe.
Simgal.
Simlo.
Tevastor
Liptonorm.
Zorstat.
Simvacol.
Vasilip.
Aries
Simvastatin.
Mertenil.
Vazator.
Zokor.
Atorvastatin.
Anvistat.
Atoris.
Atocord.
Lipona.
Chinyengo.
Novostat.
Torvalip.
Holetar.
Mevacor.
Atomax

Maholide ndi mtengo

Mtengo wapakati wa Rosuvastatin (mapiritsi 10 mg No. 30) ku Moscow ndi 325 rubles. Yoperekedwa ndi mankhwala.

Alumali moyo wa mapiritsi ndi zaka 2 kuyambira tsiku lopanga. Mankhwalawa amayenera kusungidwa m'mawu ake oyamba, m'malo amdima, pamtunda wouma osaposa +25 C. Pewani ana.

Ndemanga mwatsatanetsatane wa odziwika bwino komanso otsika mtengo a mankhwala "Rosuvastatin"

Rosuvastatin ndi amodzi mwa mankhwala othandiza kuchepetsa matenda a lipid. Ngati, pazifukwa zingapo, mwachitsanzo, kusowa kwa mankhwala am'deralo kapena mtengo wokwera, wodwalayo sangathe kugula mankhwalawo, ndiye kuti m'malo mwake mungagulitsidwe ndi analogue yotsika mtengo kwambiri, yomwe pali Rosuvastatin yambiri.

Zambiri pazamankhwala ndi malangizo ogwiritsira ntchito

Rosuvastatin (Rosuvastatin) - Ichi ndi mankhwala a lipid-otsitsa a m'badwo wotsiriza wa IV (watsopano) kuchokera ku gulu lochulukirapo lama pharmacological la ma statins, chophatikizira chomwe chiri mankhwala omwe amapezeka ndi dzina lomwelo rosuvastatin mu mawonekedwe a calcium salt (calcium rosuvastatin).

Mankhwalawa adakonzedwa kuti apangitse cholesterol yayitali (hypercholesterolemia) yosatha, yomwe singagwiritsidwe ntchito ndi mankhwala osagwiritsa ntchito mankhwala.Amadziwikanso monga gawo la zovuta za mitundu ina ya mkodzo wamafuta (dyslipidemia), kupewa matenda osokoneza bongo komanso kuchotsa kwa kusintha kwa atherosselotic pamakoma amitsempha yamagazi.

Kuchita kwa ma statins kumakhazikitsidwa ndikuletsa kwa enzyme, yomwe imayang'anira kupanga cholesterol ndi chiwindi (gwero la pafupifupi 80% ya chinthucho).

Njira yamachitidwe Rosuvastatin imakhala yoletsa enzyme - HMG-CoA reductase, yomwe ndi "progenitor" wa endo native synthesis wa cholesterol (Chol, cholesterol) m'chiwindi. Chifukwa cha izi, kuchuluka kwa ma receptor omwe amadzaza ndi otsika kwambiri lipoprotein kumawonjezera, komwe kumapangitsa kuti thupi lawo liziwuka komanso lizichoka m'thupi.

Zotsatira zake, motsutsana ndi momwe ntchito mankhwalawo imagwiritsidwira ntchito, pamakhala kuchepa kwa cholesterol "yoipa" (LDL, LDL), komanso kuchuluka kwa cholesterol "chabwino" (HDL, HDL) m'mwazi kumawonjezera kulipirira.

Mankhwalawa amapezeka mu mawonekedwe a mapiritsi okhala ndi filimu, omwe amayenera kumwa okha mkati (pakamwa), ndi madzi osachepera 100-150 ml, nthawi iliyonse masana, mosasamala chakudya.

Kuphatikizika koyambirira kwa Rosuvastatin kumaphatikizapo shuga ya mkaka (lactose) monohydrate, kupezeka kwake komwe kumapangitsa kuti mankhwala asadziwike kwa odwala omwe ali ndi vuto limodzi ndi anthu omwe ali ndi vuto lactase.

Malangizo Rosuvastatin amasankhidwa ndi dokotala mosamalitsa, kutengera kuzunzika konseko. Kulandila kumayamba ndi mlingo wocheperako (5-10 mg kamodzi patsiku) ndikuwonjezereka ngati pakufunika (malinga ngati palibe zoyipa).

A lipid-kutsitsa kwenikweni kutha kuwonedwa pambuyo 79 patatha masiku chiyambi cha mankhwala, ndipo pambuyo 2-2 milungu ukufika 90-100% ya pazotheka zotheka, amene amasungidwa mu nthawi yonse ya wokhazikika kudya Rosuvastatin.

Ndani wopanga bwino?

Mankhwala oyamba a Rosuvastatin adapangidwa ndi kampani yaku Japan Shionogi & Co (Shionogi & Co), komabe, mayendedwe ake amapangidwa pansi pa dzina lopanda mgwirizano wapadziko lonse (INN) ndi makampani ena opanga mankhwala:

Russian - Pharmstandard (Phstandard), Ozone (Ozon), Canonfarma (Kanonfarma), FI Obolenskoye (OBL Pharm),
wakunja - Astra Zeneca (Astra Zeneca), Gideon Richter (Gedeon Richter), Actavis (Actavis), Belupo (Belupo).

Makampani onsewa amatulutsa zamagetsi, i.e., kukopera mankhwala, omwe amagwiritsidwa ntchito omwe ali omwewo rosuvastatin, koma amasiyana ndi kukula koyambirira kwa mzere waukadaulo wopangira, dzina lamalonda ndi kuchuluka kwa opeza.

Popeza kuyimilira mwachindunji kotereku kumagwirizana kwathunthu ndi koyambirira, pakuwona momwe zimagwirira ntchito, zilibe kanthu kuti ndi kampani yanji yomwe ikanakonda kugula, koma mutaganizira kuti Rosuvastatin imatengedwa kwa nthawi yayitali, ndizomveka kulabadira mankhwala otsika mtengo a kunyumba.

Ma analogi odziwika kwambiri ndi kuloweza kwa rosuvastatin

Tisanalingalire za mtundu wa Rosuvastatin mwachindunji, ndikofunikira kudziwa kuti, ngakhale atasankhidwa ndi dokotala, wodwalayo ali ndi ufulu wosankha mtundu woyenera, poganizira zomwe amakonda, chikwama ndi kusalolera payekha pazinthu zina. Chachikulu ndikutsatira mlingo womwe waperekedwa.

Roxera ali ndi zokutira zolimba makamaka, zomwe zimapangitsa kuti rosuvastatin amasulidwe yekha m'matumbo aang'ono, momwe mapiritsiwo amawamwetsa osasinthika, ndipo samayikidwa pakuwonongeka kwa madzi a m'mimba.

Zomwe zimapangidwira: butyl methacrylate ndi methylryacoplate patolymers zowonjezeredwa ndi chigobacho.

Kampani yopanga: KRKA, Slovenia.

Mtengo wa mankhwala: kuchokera 383 RUB / 30 ma PC 5 mg mpaka 1617 ma ruble / 90 ma PC. 20 mg aliyense.

Rosucard (Rozucard) amadziwika ndi bioavailability wabwino (20%), koma yogwira mankhwala rosuvastatin amachotsedwa msanga mthupi, chifukwa chake mankhwalawo ali ndi tanthauzo loti achire.

Zomwe zimapangidwira: m'malo mwa hypromellose pamapangidwe oyambira, croscarmellose imagwiritsidwa ntchito ngati ufa wophika.

Kampani yopanga: Zentiva, Czech Republic.

Mtengo wa mankhwala: kuyambira 613 rub. / 30 ma PC. 10 mg mpaka 2708 ma ruble / 90 ma PC. 40 mg aliyense.

Madokotala amalimbikitsa

Kuti muchepetse cholesterol moyenera komanso kupewa atherosulinosis popanda mavuto, akatswiri amalimbikitsa kuti pakhaleol. Mankhwala amakono:

kutengera ndi amaranth ogwiritsidwa ntchito pochiza matenda amtima,
amalimbikitsa kupanga "cholesterol" wabwino, ndikuchepetsa kupanga "koyipa" ndi chiwindi,
Amachepetsa kwambiri vuto la kugunda kwa mtima ndi sitiroko,
imayamba kuchita pakatha mphindi 10, zotsatira zake zimakhala zowonekera pambuyo pa masabata atatu.

Kuchita bwino kumatsimikiziridwa ndi machitidwe azachipatala ndi kafukufuku wa Research Institute of Therapy.

Mertenil (Mertenil) ali ndi chiyero chambiri choyeretsa chomwe chimagwira. Izi zimathandizira kulolerana kwa mankhwalawa ndi zovuta zochepa, zomwe ndizofunikira kwambiri mukamamwa rosuvastatin odwala okalamba.

Zomwe zimapangidwira: imagwirizana ndi choyambirira, kupatula pazinthu zomwe zimagwiritsidwa ntchito kupaka utoto.

Kampani yopanga: Gedeon Richter, Hungary.

Mitengo muma pharmacies: kuchokera 478 rub. / 30 ma PC. 5 mg mpaka 1439 ma ruble / 30 ma PC. 40 mg aliyense.

Rosulip (Rosulip) ndi analogue wotsika mtengo wa Rosuvastatin, yemwe ali ndi bioavailability wambiri ndipo amadziunjikira pang'onopang'ono, zomwe zimakuthandizani kuti pang'onopang'ono mupange chidziwitso chofunikira chazogwiritsa ntchito m'thupi.

Zomwe zimapangidwira: ili ndi rosuvastatin osati mwa calcium, koma munthawi ya mchere wa zinc (rosuvastatin zinc).

Kampani yopanga: EGIS (EGIS Pharmaceuticals PLC), Hungary.

Mtengo wa mankhwala: kuchokera 469 RUB / 28 ma PC 5 mg mpaka 1087 rubles / 28 ma PC. 20 mg aliyense.

Crestor (Crestor) - mankhwala okhawo oyambira rosuvastatin. Mankhwala omwe atengedwawo amadziwika ndi kukonzanso kwapamwamba kwambiri kwa chinthu chogwira ntchito ndipo, ngati mumadalira mayankho a wodwala, kulolera bwino, koma pamtengo ndi wokwera mtengo kwambiri kuposa ma genetic ena.

Zomwe zimapangidwira: Zosakaniza zonse ndizofanana ndi chokhalira choyambirira.

Kampani yopanga: Astra Zeneca, United Kingdom.

Mitengo muma pharmacies: kuyambira 1756 rub. / 28 ma PC. 5 mg iliyonse mpaka 5036 rub./28 ma PC. 40 mg aliyense.

Tevastor ndi imodzi mwazifanizo zabwino za Rosuvastatin, chifukwa zimadziunjikira mwachangu m'thupi, kutulutsa mankhwala, ndipo nthawi yomweyo imakhala yotsika mtengo kwambiri kuposa mankhwala oyambirirawo.

Zomwe zimapangidwira: pafupifupi lenten yofanana ndi yoyambayo (kupatula utoto).

Kampani yopanga: TEVA (TEVA Pharmaceutical Industries Ltd), Israel.

Mtengo wa mankhwala: kuchokera 341 rub. / 30 ma PC. 5 mg mpaka 1522 rubles / 90 ma PC. 20 mg aliyense.

Rosuvastatin-SZ

Rosuvastatin-SZ (Rosuvastatin-SZ) - lero ndiwotsika mtengo kwambiri ku Rosuvastatin kuchokera ku wopanga waku Russia. Ngakhale mtengo wotsika kwambiri, siwotsika mtengo kuposa mitundu yonse komanso ulinso ndi zofanana ndi zoyambirira.

Zomwe zimapangidwira.

Kampani yopanga: FC Severnaya Zvezda ZAO, Russia

Mtengo wa mankhwala: kuchokera 178 rub. / 30pcs. 5 mg mpaka 684 rubles / 30 ma PC. 40 mg aliyense.

Kuphatikiza pa ma statins, palinso njira zina. Owerenga amalimbikitsa mankhwala achilengedwe, omwe, kuphatikizapo zakudya komanso ntchito, amachepetsa kwambiri mafuta m'thupi pambuyo masabata 3-4. Maganizo a madotolo >>

Rosart (Rosart) ali ndi zabwino zonse zamankhwala oyambira ndipo samakhala ndi vuto lililonse mthupi, chifukwa zinthu zonse zomwe zimagwira ndi zothandiza zimatsukidwa bwino. Titha kunena kuti ichi ndi cholowa m'malo mwa rosuvastatin.

Zomwe zimapangidwira: zosakaniza zonse ndizofanana pakukonzekera koyambirira.

Kampani yopanga: Gulu la Actavis, Iceland

Mitengo muma pharmacies: kuyambira 426 RUB / 30 ma PC 5 mg mpaka 2347 rub./90 ma PC. 40 mg aliyense.
Zinthu zomwe zimachepetsa cholesterol ndikuyeretsa m'mitsempha yamagazi.

Mankhwala onse othandiza kwambiri a cholesterol mwanjira ya mapiritsi.

Momwe mungagwiritsire ntchito mankhwala a Rosuvastatin Canon?

Rosuvastatin Canon, yopangidwa ndi Canonfarm Production CJSC, njira yabwino yotsitsira triglycerides ndi cholesterol.

Momwe angatenge

Asanagwiritse ntchito, piritsi limaphatikizidwa kuti lipukute, limatha lonse, kutsukidwa ndi madzi oyera. Mlingo umasankhidwa ndi adokotala, poganizira momwe njira zina zimathandizira, kuyankha kwa mankhwala, kutsimikizira kwa lipid, kuopsa kwa matenda a mtima.

Mlingo woyambira wabwino ndi 10 mg kamodzi patsiku. Kukula kwa mankhwalawa ngati akuwonetsedwa ndikololedwa pambuyo pa masabata anayi atamwa mankhwalawa. Pambuyo kukulitsa mlingo, kuyezetsa ndikofunikira kuti muwone momwe mulidi wa lipids.

Zotsatira zoyipa za rosuvastatin canon

Kumwa mankhwalawa kungayambitse chizungulire, mseru, kudzimbidwa kapena kutsegula m'mimba, asthenic syndrome. Nthawi zina, wodwalayo amayamba kukumbukira kuiwala, hepatitis, kupuma movutikira, kupweteka kwa mutu.

Zomwe zimachitika musculoskeletal system yogwira ntchito ikhoza kukhala chitukuko cha myopathy, arthralgia, myalgia, rhabdomyolysis ndi kupweteka kwambiri kwaimpso. Zotsatira zina zoyipa za mankhwalawa ndi monga:

Type 2 shuga.
Proteinuria
Kukhumudwa
Kusokonezeka tulo, kugona.
Anatsika libido.

Ndi kukula kwa yankho loipa kuchokera ku chitetezo chamthupi, zotupa pakhungu, urticaria, ndi Quincke edema zimatha kuchitika.

Zotsatira za mankhwalawa zimadzetsa kusintha kwa magawo a labotale, kuphatikizapo ntchito ya hepatic transaminases, kuchuluka kwa glucose, mahomoni a chithokomiro ndi bilirubin.

Gwiritsani ntchito pa nthawi yoyembekezera komanso mkaka wa m`mawere

Phindu lomwe amamwa chifukwa chomwa mankhwalawo limaposa zovuta zomwe zimachitika kwa mwana wosabadwayo, chifukwa chake mankhwalawa amatsutsana panthawi yoyembekezera. Palibe chidziwitso chokhudza chitetezo cha mankhwalawa panthawi ya mkaka wa m`mawere, zomwe zimafuna kukana chithandizo kapena kusamutsa mwana kuti akudya mozizwitsa panthawi ya chithandizo.

Ndemanga za Odwala

Roman, wazaka 43, Moscow

Mankhwalawa adalembedwa kuti achepetse chiopsezo cha matenda a mtima. Kwa miyezi isanu ndi umodzi, zizindikiro za cholesterol zasintha kukhala zabwino. Ndinkamwa mapiritsiwo molingana ndi malangizo onse a mtima.

Malangizo ogwiritsira ntchito mindandanda yayitali yazotsatira zoyipa, pali ndemanga zambiri zolakwika pa intaneti, kotero poyamba sindinkaopa kumwa mapiritsi awa.

Koma palibe zomwe sizinachitike zomwe zimachitika, ndipo zotsatira zake zimakhala zapamwamba.

Olena Alekovna, wazaka 51, Kiev

Mankhwalawa adayamba ndi Dibikor, mkhalidwe utakula, pomwe kuchuluka kwa triglycerides kunali kovuta, ndiyenera kuyamba kumwa mankhwalawa. Zotsatira zake zikuyembekezeka, koma kukwaniritsa kwake kudula mtengo. Zotsatira zoyipa zidawonekera. Pambuyo pakupuma mokakamiza, Dibicor adasankhidwa.

Mankhwalawa ndi othandizika kwambiri, koma ali ndi vuto loyipa m'magazi, amakhumudwitsani mawonekedwe a zovuta, mutu. Ndinafunikira kuthandizidwa ndikupirira mavuto osaneneka, ndipo pokhapokha ndikuyang'ana njira yochotsera.

Mlingo ndi mawonekedwe a statin

Pulogalamu yamankhwala, Rosuvastatin amagulitsidwa ngati mapiritsi a convex ozungulira mu chipolopolo cha pinki, kuti apangidwe pakamwa.

Chofunikira chachikulu pa mankhwalawa ndi rosuvastatin, kuchuluka kwa rosuvastatin piritsi kumatengera mawonekedwe a kumasulidwa: 5.10 kapena 20 mg mu chidutswa chimodzi.Statin imathandizidwa ndi zigawo zothandiza: hypromellose, starch, dioksidi ya tonic, crospovidone, cellcrystalline cellulose, silicon dioxide, utoto wa utoto, triacetin, silicon dioxide, magnesium stearate.

Mankhwalawa amamuika m'mbale yodzaza ndi maselo 10 limodzi. Mu bokosi la makatoni pakhoza kukhala atatu kapena 6 ambale oterowo, owonjezeredwa ndi malangizo ogwiritsira ntchito mankhwalawa.

Zotsatira za pharmacological

Yogwira pophika mankhwala ali ndi lipid-kuchepetsa. Rosuvastatin linalaketsa enzyme HMG-CoA reductase, amene ali ndi vuto lopanga mevalonate - woyamba wa mafuta m'thupi. Chidacho chimakhudza mwachindunji ma hepatocytes (ma cell a chiwindi), omwe ali ndi vuto lopanga cholesterol yawo (yamkati).
Poonjezera kuchuluka kwa ma lipoprotein otsika kwambiri pama hepatocides, amathandizira kuthana ndi cholesterol owonjezera kuchokera kumazungulira, kumathandizira kuchepetsa kupanga kwa VLDL, chifukwa ndi lipoproteins yokhala ndi kachulukidwe kochepa kwambiri kamene kamakhala koopsa pamitsempha yamagazi.

Kusiyana kwakukulu pakati pa Rosuvastatin ndi ma statins ena ndikuti sikumangolimbana ndi cholesterol "yoyipa" yokha, komanso kumayimitsa kutupa kosafunikira, komwe, malinga ndi asayansi ambiri, ndiye chifukwa chachikulu cha atherosulinosis.

Mankhwalawa amathandizira kapangidwe ka nayitrogeni, omwe amathandizira kutsitsimutsa kwamitsempha yamagazi, ndikupanga zomwe zimatchedwa pleiotropic (zowonjezera).

Mukatha kugwiritsa ntchito statin, chophatikizacho mwachangu, ngakhale sichimangolowa mthupi, chimagawidwanso m'chigawo chonse cha thupi. Imamwa kwambiri pang'onopang'ono kuposa anzanga ndipo nthawi yowachotsayo ndi yayitali.

Pazipita plasma ndende ya yogwira pophika amawona 5 mawola ingestion. Ngakhale kuti mankhwalawa amalembedwa muyezo wotsika kuposa ma analogues, ma pharmacokinetics amalola rosuvastatin kuti azigwirizana pang'ono ndi mankhwala ena poyerekeza ndi ma statins a mibadwo ina. Tsoka ilo, izi sizimamupulumutsa ku zoyipa.

Mosiyana ndi ma statins ambiri, mankhwalawa sakhala ndi mapangidwe a chiwindi: 5% ameta impso, ndipo makamaka (90%) amasiya matumbo momwe anali.

Zolepheretsa ndi zotsutsana

Mapiritsi a rosuvastatin, malangizo ogwiritsira ntchito amalimbikitsa mndandanda wambiri wa zotsutsana ndi malire:

Kusagwirizana ndi chida chilichonse chamawonekedwe,
Nthawi ya kubereka ndi mkaka wa m'mawere, kusowa kwa njira zakulera zapakati pa chonde, zomwe sizimalola kupatula kutenga pakati kosakonzekera panthawi ya mankhwala a rosuvatin,
Zaka za ana (mpaka zaka 18), kupatulapo achinyamata omwe ali ndi cholowa cha hypercholesterolemia,
Pachimake chiwindi kulephera chifukwa kuphwanya ntchito yake vuto kuwonongeka hepatocytes ndi mkulu plasma zili hepatic transaminases (michere),
Kugwiritsa ntchito cyclosporine panthawi yomweyo,
Myopathy (matenda a minofu yolimba ya mafupa) kapena chizolowezi chodzikulitsa.

Kugwiritsa ntchito mankhwalawa muyezo waukulu (40 g) kumakhala ndi zowonjezera zina:

Uchidakwa wambiri
Zinthu zomwe zikuwonjezera kuchuluka kwa plasma ndende ya rosuvastatin,
Kukonzekera kwa myopathy,
Kuchepa kwa impso
Myotoxicity pochiza mankhwala ena omwe amachepetsa enzyme HMG-CoA reductase,
Chithandizo chokwanira ndi fibrate.

Mlingo wokwanira sukhazikitsidwa kwa anthu amtundu wa Mongoloid. Izi zimayeneranso kukhala maziko a kusamala mosamala kwa statin munjira ina. Asanapange mankhwala a Rosuvastatin, adotolo ayenera kuonetsetsa kuti zikugwirizana, chifukwa chake ndikofunikira kumamuwuza za mankhwala onse, zowonjezera zakudya, zitsamba zomwe zikumwa masiku ano.

Rosuvastatin: malangizo ogwiritsira ntchito

Piritsi liyenera kukhala loledzera ndi madzi nthawi zonse. Kudya sikukhudza ntchito yake, koma popeza cholesterol imapangidwa usiku, mankhwalawa nthawi zambiri amaperekedwa kuti agwiritsidwe ntchito usiku.

Ngati ma statins amagwiritsidwa ntchito kwa nthawi yoyamba, osapitirira 5-10 mg / tsiku ndi omwe adayikidwa. limodzi. Potsika mtengo mankhwalawa mankhwala 2 mg / tsiku. Mankhwala okwanira tsiku ndi tsiku (40 g) amawonetsedwa kokha chifukwa cha hypercholesterolemia, popeza mwayi wazotsatira zimakula kwambiri.

Ndi concomitant aimpso kapena kwa chiwindi chothandizira kuwonongeka, chizolowezi cha myopathy, nthumwi za mtundu wa Mongoloid, mlingo woyambayo wosapitilira 5 g. Kutalika kwa nthawi ya mayeserowa kumatsimikiziridwa ndi adokotala, koma kusintha kwa mankhwalawa sikungatheke kuposa mwezi umodzi.

Machitidwe oyamba amawoneka pakatha sabata, mankhwala awiri atatha kale 90%. Mokwanira, Rosuvastatin amawonekera sabata lachitatu la kudya pafupipafupi. M'tsogolo, zotsatira zake zimapulumutsidwa.

Mankhwalawa satengedwa m'maphunziro, ma statins amawonetsedwa moyo, ndikusintha kwa mlingo ngati kuli kofunikira. Popanda kudya komanso kukhala ndi thanzi labwino, mankhwala osokoneza bongo ndi osathandiza. Momwe mungachepetse cholesterol m'njira zotsika mtengo, yang'anani vidiyo

Zotsatira zoyipa

Potengera momwe mankhwalawa amathandizira, kupangika kwa zosayembekezereka kuchokera ku ziwalo zambiri ndizotheka:

Matumbo am'mimba - zovuta za dyspeptic, kusintha kwa kayendedwe ka matumbo, nthawi zina kapamba imayatsidwa,
CNS - kufooka kwathunthu, kupweteka mutu, kusokonezeka kwa mgwirizano,
Endocrine dongosolo - mtundu 2 shuga mellitus (DM),
Ziwalo za genitourinary - proteinuria ndi hematuria,
Matenda a minofu ndi mafupa - myasitis, myalgia, rhabdomyolysis (kuwonongeka kwa minofu ndikapangira mankhwala oopsa a impso), ndizowopsa makamaka ndi chizolowezi cha myopathy,
Chifuwa - ming'oma, totupa, ndi kuyabwa kwa khungu.

Kuopsa kwa zotsatira zosayembekezereka kumadalira mlingo. Mukalandira chithandizo cha rosuvastatin ndi mlingo waukulu (40 mg / tsiku), kufalikira kwawo kumawonjezeka. Mawonekedwe amtunduwu ndiye maziko osinthira a mankhwalawa kapena kusintha kwa mankhwala.

Malangizo apadera

Posankha rosuvastatin, dokotala amatenga malangizo apadera:

Kuchiza kwa nthawi yayitali ndi statin, makamaka pamlingo waukulu, kumawunikira kuwunikira pafupipafupi zamankhwala a CPK enzyme (creatine phosphokinase) kuteteza matenda am'matumbo, makamaka mtima.
Kugwiritsanso ntchito komweko kwa mankhwala omwe amalepheretsa chiwonetsero cha HMG-CoA kuchepa kwamphamvu kumafuna njira yosamala ndikuwonetsetsa momwe wodwalayo aliri.
Asanayambe ma statins, wodwalayo ayenera kudziwitsidwa za zovuta zomwe zingakhalepo pamisempha, chifukwa chake ululu uliwonse wa minofu uyenera kukhala chifukwa chochezera ndi dokotala.
Poyerekeza ndi kugwiritsa ntchito kwa Rozuvatsatin, milandu ya myasthenia (kufooka kwa minofu) yomwe imapangidwa ndi kapangidwe ka chitetezo chamthupi cha autoantibodies yalembedwa.
Ndi kusintha kwa mlingo, komanso masabata aliwonse a 2-4, zomwe plasma ya cholesterol ndi lipids imayang'aniridwa.
Asanayambe maphunzirowo mobwerezabwereza, patatha milungu ingapo, kuwunika kwa labotale mphamvu ya chiwindi ndikofunikira.
Rosuvastatin amatha kulumikizana ndi mankhwala ena, pomwe amamwa, muyenera kuchenjeza dokotala musanapange regimen.
Popeza kukonzekera kumakhala ndi lactose, kuphwanya mayamwidwe am'mimba m'matumbo (kuperewera kwa lactase, glucose-galactose malabsorption), izi ziyenera kukumbukiridwa.
Statin imakhudzanso kuyamwa kwa shuga, kuwonjezereka kwa ndende yake ya plasma kumathandizira kuti chiwonetsero cha matenda ashuga a 2 chikhale, kuwunika kwazizindikiro zake ndikofunikira.
Palibe zambiri zokhudzana ndi mphamvu ya rosuvastatin pa chidwi, magwiridwe antchito a ubongo, komanso momwe angachitire.

M'mafakisoni, mankhwalawa amamasulidwa pamaso pa mankhwala omwe dokotala amupatsa, chithandizo chokha chokhala ndi ma statins sichovomerezeka.

Zotsatira za kuyanjana ndi mankhwala ena

Ndi kuperekera pamodzi ndi mankhwala ena, ndizotheka kusintha mawonekedwe a statin kapena mankhwalawa, chifukwa chake adotolo ayenera kudziwa ndikuganizira zovuta zonse.

Kulumikizana ndi nicotinic acid zotumphukira kumawonjezera mwayi wa kusokonezeka kwa impso ndi rhabdomyolysis.
Kuchita ndi diuretics kumawonjezera chiopsezo chochepetsa kuchuluka kwa mahomoni a steroid.
Kugwiritsira ntchito mankhwalawa kwa statin ndi mankhwala ena ochepetsa a lipid kumawonjezera chiopsezo cha zovuta zosiyanasiyana.
Kugawana ndi mtima glycosides kumakulitsa digoxin.
Ma immunosuppressants osakanikirana ndi rosuvastatin angakhudze kukula kwa aimpso ndi rhabdomyolysis.
Kulumikizana ndi ma anticoagulants kumawonjezera mwayi wokhetsa magazi.
Mankhwala osokoneza bongo a antifungal pamagetsi amawonjezera ngozi ya kukanika kwa impso ndi rhabdomyolysis.
Kumwa mowa wofanana kumawonjezera mwayi wamatenda a chiwindi.

Kuthandiza ndi bongo

Ndi munthawi yomweyo kugwiritsa ntchito mapiritsi ambiri owonjezera tsiku ndi tsiku, zizindikiro za bongo sizimawoneka, chifukwa pharmacokinetics yogwira pophika mankhwala imakhalabe yoyambira.

Mankhwala osokoneza bongo owonjezereka amatha kukulitsa zizindikiro za zovuta zomwe zimachepetsa kukomoka kwa m'mimba, kugwiritsa ntchito matumbo am'mimba, komanso chithandizo chamankhwala.

Mankhwala apadera a rosuvastatin sanapangidwe.

Mankhwala ofanana

Rosuvastatin wakhala akudziwika pamsika wamankhwala kuyambira 2003. Malinga ndi achire zotsatira ndi kapangidwe ka

Anu a Rosuvastatin lero ndi:

Rosuvastin SZ,
Mertenil
Tevastor
Roxer
Rosuvastatin Canon,
Rosicore
Rosulip,
Crestor
Rosistark,
Rosart,
Akorta,
Rosucard,
Torvacard.

Malinga ndi mtengo wa chithandizo, gululi litha kugawidwa m'magulu atatu: zomwe zimapangidwira ndalama zambiri: Rosuvastatin Canon, Rosuvastatin SZ, Akorta (rubles 250-650), mtengo wamba: Rosart, Mertenil, Tevastor, Roxer, Rosucard, Rosulip (400- 900 rubles) , wokondedwa: Crestor (1100-2200 rub.). Kwa ma rosuvatin analogues, kuwunika kwamtengo kunachitika m'mabokosi okhala ndi mapiritsi 10 mg.

Mulingo wa ogwiritsa

About Rosuastatin, zowunikirazi ndizodzaza ndi mantha pokhudzana ndi zovuta zomwe zingachitike, koma sizitchedwa kuti cholinga. Madandaulo ambiri (chifuwa, kutopa, kupweteka kwa minofu) samachitika chifukwa cha Rosuvastatin, koma ndi mitengo yotchipa yopangidwa ku India ndi mayiko omwe kale anali Soviet Union. Madokotala amapereka Krestor kapena zida zapamwamba kwambiri zopangidwa ku Eastern Europe.

Zotsatira za kafukufuku wapadziko lonse wa ROSU-PAZ ku Rosuvastatin zitha kupezeka pavidiyo

Rosuvastatin adalembedwa kuti azilamulira atherosulinosis. Ndi makulidwe azachulukidwe a lipid, kuchuluka kwa vuto la mtima, kugunda kwa m'mimba kumachepa, palibe chifukwa chochita opaleshoni yodukiza komanso yodutsa m'mitsempha, ndikusintha magazi kulowa m'miyendo ndi njira zopangira opaleshoni.

Mpikisano waukulu lero ndi pakati pa m'badwo waposachedwa wa ma statins. Rosuvastatin imakhudzanso cholesterol, koma poganizira zotsatira zake zoyipa, nthawi zina zimakhala zofunikira kupangira ena othandizira.

Kumwa ngakhale mankhwala amphamvu ngati awa kungangothandiza kusinthika kumikhalidwe yatsopano ya moyo, sichingalowe m'malo ndi kufunika kwa zakudya ndi minofu.

Madokotala amafufuza

Elena Alekseevna, wowerenga zamitima, ku Moscow

Mankhwalawa ndi amodzi mwa mankhwala aku Britain, koma ndi othandiza kwambiri. Ngati mutsatira zakudya komanso mlingo woyenera, zotsatira zoyipa sizimakula ndipo zimakhala zofatsa.Nthawi yomweyo, mtengo wa mankhwalawo umakhalabe wokwera mtengo kwa odwala ambiri.

Tatyana Valerievna, phlebologist, Samara

Nthawi zambiri, mitsempha ya varicose sikuti ndi chifukwa chokha cholakwika ndi mtima. Kuti muwonjezere kuchuluka kwa mankhwalawa, mwina pangafunike kuchepetsa kuchuluka kwa mafuta m'thupi, omwe amathandizira kugwiritsa ntchito ma statins, koma ndikofunikira kutsimikizira wodwalayo kuti azitsatira malangizo onse okhudzana ndi zakudya, nthawi ya mankhwala komanso mlingo.

Kuphatikizidwa kwa mapiritsi awa mu maphunziro azachipatala ndikofunikira mu milandu yayikulu ndipo pokhapokha atakambirana ndi cardiologist ndikusankhidwa kwa zakudya zoyenera. Mankhwalawa amapereka zotsatira zabwino komanso zokhazikika.

9 zotheka komanso zotsika mtengo zotumphukira za Rosuvastatin

Zolemba pazipilala
Mitu ya mankhwalawa

Rosuvastatin ndi mawonekedwe ake amafotokozedwera cholesterol m'magazi kuposa kale. Mankhwalawa ndi a gulu la statins omaliza (mibadwo 4). Poyerekeza ndi mankhwala ena omwe ali mgululi, rosuvastatin ndi njira yothandiza komanso yotetezeka.

Adapangidwa kuti apangidwe ndipo amawonetsera ma hydrophilic, chifukwa sichikhala ndi vuto lililonse pachiwindi.

Mankhwalawa amalepheretsa kupanga ma lipoprotein otsika kwambiri, omwe amakhala ngati chinthu chofunikira kwambiri kuchokera komwe cholesterol imapangidwira.

Kuphatikiza apo, kumwa mankhwalawa sikuyambitsa kukokana kwa minofu ndi ma pathologies ena kuchokera kumbali ya minofu. Mphamvu yofunikira imawonekera kale sabata pambuyo poyambira kugwiritsa ntchito, ndipo pakatha milungu 4 imakhala yotalikirapo ndipo ndi chithandizo chanthawi zonse chimatenga nthawi yayitali. Makhalidwe amenewa amapangitsa rosuvastatin kukhala mankhwala okwera kwambiri kwa odwala omwe ayenera kuchepetsa cholesterol.

Zolemba pazipilala

Chithandizo chogwira mankhwalawa ndi mchere wa calcium wa rosuvastatin. Kuphatikiza apo, kapangidwe kameneka ndikuphatikiza zina zingapo, zomwe zili ndi gawo lake:

Microcrystalline cellulose ndi adsorbent yabwino yomwe imachotsedwa osasinthika kuchokera mthupi la munthu. Mu kapangidwe kake ka mankhwalawa, imagwira ntchito monga filler ndi chinthu chomwe chimagwira kulumikiza zinthu zonse.
Lactose Monohydrate. Zogwiritsidwa ntchito pokonzanso kukoma kwa mankhwalawa. Komabe, izi zimapangitsa kuti pakhale zovuta kutenga mapiritsi a anthu omwe ali ndi vuto la tsankho kapena lactase.
Calcium calcium Ichi ndi chipangizo chophatikizira, chomwe chimaphatikizapo zitsulo zamchere ndi phosphoric acid. Kuphatikizika kwa mapiritsi kumathandizira kuti mumvetsetse zomwe zimagwira.
Magnesium wakuba. Imathandizira njira yojambulira matabuleti ndipo imagwira ntchito ngati chosungira bwino m'thupi.
Hydroxypropyl methylcellulose ndizowonjezera zapadera zothira madzi zomwe ndizofunikira pakupanga mawonekedwe a kipimo.
Povidone imagwira ntchito ngati sorbent yomwe imalepheretsa zinthu zina zoyipa m'thupi, kuphatikizapo zomwe zimapangidwa chifukwa cha zochita za rosuvastatin.
Triacetin ndi chowonjezera chovomerezeka cha chakudya (E1518). Monga gawo la mapiritsi, imagwira ntchito ngati pulasitiki ndi moisturizer, yomwe ndiyofunikira kuti ichitike.
Utoto - iron oxide ndi titanium dioxide ndizowonjezera zotetezeka kusintha mawonekedwe.

Mapiritsi a Rosuvatatin, omwe amagwiritsidwa ntchito ngati cholesterol pamwamba pazomwe amapangira, amapangidwa ndi makampani angapo azamankhwala pansi pa mayina osiyanasiyana. Onsewa ndi ma fanizo achindunji, ndiye kuti ali ndi chinthu chimodzi chogwira ntchito.

Mankhwala oyamba a Krestor amapangidwa ndi kampani yaku Chingerezi ndipo ali ndi mbiri ngati mankhwala apamwamba kwambiri. Mankhwala ena onse omwe akuphikidwa ndi rosuvastatin ndi ma genetic.

Amasiyana ndi zoyambirira mumtengo ndipo amatha kukhala ndi mawonekedwe ena othandizira, omwe samawakhudza kwambiri. Mfundoyi iyenera kukumbukiridwa ndi chidwi chochulukirapo pazinthu zina.