Mankhwala Forsig - malangizo, ntchito, ndemanga, zotsika mtengo
Tsambali limapereka mndandanda wazofanizira zonse za Forsig pakupanga ndi chisonyezo chogwiritsa ntchito. Mndandanda wama analogi otsika mtengo, mutha kuyerekezeranso mitengo muma pharmacies.
- Analogue yotsika mtengo kwambiri ya Forsig:Attokana
- Mnzanu wodziwika kwambiri wa Forsig:Jardins
- Gulu la ATX: Dapagliflozin
- Zosakaniza / yogwira: dapagliflozin
| # | Mutu | Mtengo ku Russia | Mtengo ku Ukraine |
|---|---|---|---|
| 1 | Attokana canagliflozin Mndandanda wazowonetsera ndi njira yogwiritsira ntchito | 13 rub | 3200 UAH |
| 2 | Novonorm kubwezera Mndandanda wazowonetsera ndi njira yogwiritsira ntchito | 30 rub | 90 UAH |
| 3 | Kukhazikika akusglutide Mndandanda wazowonetsera ndi njira yogwiritsira ntchito | 115 rub | -- |
| 4 | Baeta exenatide Mndandanda wazowonetsera ndi njira yogwiritsira ntchito | 150 rub | 4600 UAH |
| 5 | Jardins empagliflozin Mndandanda wazowonetsera ndi njira yogwiritsira ntchito | 222 rub | 566 UAH |
Mukamawerengera mtengo wake zotsika mtengo Forsig mtengo wocheperako womwe umapezeka mumndandanda wamapulogalamu omwe amaperekedwa ndi ma pharmacies adaganiziridwa
| # | Mutu | Mtengo ku Russia | Mtengo ku Ukraine |
|---|---|---|---|
| 1 | Jardins empagliflozin Mndandanda wazowonetsera ndi njira yogwiritsira ntchito | 222 rub | 566 UAH |
| 2 | Saxenda liraglutide Mndandanda wazowonetsera ndi njira yogwiritsira ntchito | 1374 rub | 13773 UAH |
| 3 | Kukhazikika akusglutide Mndandanda wazowonetsera ndi njira yogwiritsira ntchito | 115 rub | -- |
| 4 | Attokana canagliflozin Mndandanda wazowonetsera ndi njira yogwiritsira ntchito | 13 rub | 3200 UAH |
| 5 | Baeta exenatide Mndandanda wazowonetsera ndi njira yogwiritsira ntchito | 150 rub | 4600 UAH |
Popeza mndandanda wamankhwala osokoneza bongo kutengera ziwerengero zamankhwala omwe apemphedwa kwambiri
Analogs popanga ndi chisonyezo chogwiritsidwa ntchito
| Mutu | Mtengo ku Russia | Mtengo ku Ukraine |
|---|---|---|
| Forksiga Dapagliflozin | -- | 18 UAH |
Mndandanda womwe uli pamwambapa wa analogies ya mankhwala, omwe akuwonetsa Forsig zolowa m'malo, ndizabwino kwambiri chifukwa zimakhala ndi zinthu zomwe zimagwirizana ndipo zimagwirana molingana ndi chisonyezo chogwiritsidwa ntchito
Analogs mwa chisonyezo ndi njira yogwiritsira ntchito
| Mutu | Mtengo ku Russia | Mtengo ku Ukraine |
|---|---|---|
| Lixumia lixisenatide | -- | 2498 UAH |
| Malo a Guarem Guar | 9950 rub | 24 UAH |
| Insvada repaglinide | -- | -- |
| Novonorm Repaglinide | 30 rub | 90 UAH |
| Repodiab Repaglinide | -- | -- |
| Baeta Exenatide | 150 rub | 4600 UAH |
| Baeta Long Exenatide | 10248 rub | -- |
| Viktoza liraglutide | 8823 rub | 2900 UAH |
| Saxenda liraglutide | 1374 rub | 13773 UAH |
| Invocana canagliflozin | 13 rub | 3200 UAH |
| Jardins Empagliflozin | 222 rub | 566 UAH |
| Trulicity Dulaglutide | 115 rub | -- |
Zambiri, kapangidwe, mawonekedwe omasulira
Posachedwa, gulu latsopano la mankhwala omwe ali ndi zinthu zotsitsa shuga, koma okhala ndi zotsatira zosiyana poyerekeza ndi mankhwala omwe kale amagwiritsidwa ntchito, apezeka ku Russia. M'modzi mwa oyamba mdziko muno adalembetsa mankhwala a Forsig.
Wothandizidwa ndi pharmacological amaperekedwa mu radar system (registry ya mankhwala) ngati mankhwala a hypoglycemic omwe cholinga chake ndi pakamwa.
Akatswiri pakuchita maphunzirowa adatha kupeza zotsatira zochititsa chidwi, kutsimikizira kuchepetsa kuchuluka kwa mankhwala omwe amwedwa kapena kuletsa nthawi zina mu insulin chifukwa chogwiritsa ntchito mankhwala atsopano.
Ndemanga za endocrinologists ndi odwala pankhaniyi ndizosakanikirana. Ambiri amasangalala ndi mwayi watsopano, ndipo ena a iwo amaopa kuugwiritsa ntchito, kuyembekezera chidziwitso cha zotsatira za kugwiritsidwa ntchito kwa nthawi yayitali.
Mankhwalawa amapezeka mu mawonekedwe a mapiritsi okhala ndi Mlingo wa 10 kapena 5 mg ndipo amamuyika m'matumba ambiri, 10 komanso zidutswa 14.
Piritsi lirilonse limakhala ndi Dapagliflozin, chomwe ndicho chimagwirira chachikulu.
Zabwino zimaphatikizaponso zinthu zotsatirazi:
- cellcrystalline mapadi,
- michere ya m'magazi,
- silika
- crospovidone
- magnesium wakuba.
- mowa pang'ono wa hydrolyzed polyvinyl (Opadry II wachikasu),
- titanium dioxide
- macrogol
- talcum ufa
- Utoto wachikasu wachitsulo.
Zotsatira za pharmacological
Dapagliflozin, wogwira ntchito ngati mankhwala, amalepheretsanso SGLT2 (mapuloteni), ndiye kuti, amachepetsa ntchito yawo. Mothandizidwa ndi zinthu zamankhwala, kuchuluka kwa glucose omwe amachokera ku mkodzo woyamba amachepetsedwa, chifukwa chake, kutulutsa kwake kumachitika kwathunthu chifukwa cha ntchito ya impso.
Izi zimabweretsa matenda a magazi glycemia. Chowoneka mosiyana ndi mankhwalawa ndi kusankha kwake kwapamwamba, chifukwa sichikhudza kayendedwe ka glucose kupita ku minofu ndipo sikasokoneza mayamwidwe ake akalowa matumbo.
Chofunikira chachikulu cha mankhwalawa chimaperekedwa kuti athetse matenda a impso, omwe amakhala ndi magazi. Thupi laumunthu limadziwika nthawi zambiri kuzinthu zosiyanasiyana za metabolic komanso poizoni.
Chifukwa cha ntchito yokhazikika ya impso, zinthu izi zimasefedwa bwino ndikuchotsa limodzi ndi mkodzo. Mukukonzekera kwakumwa, magazi amadutsa kangapo kudzera mu mawonekedwe a impso. Zigawo zamapuloteni zimasungidwa poyambilira m'thupi, ndipo timadzi tonse tomwe timatsalira timasefedwa, ndikupanga mkodzo woyamba. Kuchuluka kwake patsiku kungafike 10 malita.
Kutembenuza madziwo kukhala mkodzo wachiwiri ndikulowetsa chikhodzodzo, kuyika kwake kuyenera kuchuluka. Cholingachi chimakwaniritsidwa ndikubweza m'magazi pazinthu zonse zofunikira, kuphatikizapo shuga.
Pakalibe matenda, zinthu zonse zimabwezedwa kwathunthu, koma ndi matenda ashuga pamakhala kutayika kwa shuga mu mkodzo. Izi zimachitika pamlingo wa glycemia woposa 9-10 mmol / L.
Kumwa mankhwalawa muyezo wabwino kumalimbikitsa kutulutsa kwa 80 g m'magazi a mkodzo. Kuchuluka kumeneku sikudalira kuchuluka kwa insulin yomwe imapangidwa ndi kapamba kapena kulandira jakisoni.
Kuchotsa shuga kumayamba pambuyo piritsi, ndipo zotsatira zake zimatha kwa maola 24. Zomwe zimagwiritsidwa ntchito ndi mankhwalawa sizikukhudza masoka opanga glucose wamkati pakachitika hypoglycemia.
Pazotsatira za mayesowa, kuwongolera kunawonekera pakugwira ntchito kwa maselo a beta omwe amayang'anira kupanga mahomoni. Odwala omwe amamwa mankhwalawa mlingo wa 10 mg kwa zaka ziwiri, shuga anali kuwachotsa, zomwe zimapangitsa kuchuluka kwa osmotic diuresis. Kuwonjezeka kwamkodzo kwamkodzo kumatha kuyenda limodzi ndi kuchuluka kwa sodium excretion kudzera mu impso, koma sikunasinthe phindu la seramu ndende ya chinthu ichi.
Kugwiritsidwa ntchito kwa Forsigi kumathandizira kutsika kwa kuthamanga kwa magazi kale pakatha masabata 2-4 atayamba kuyang'anira. Kuphatikiza apo, kugwiritsa ntchito mankhwalawa kwa miyezi itatu kumachepetsa glycosylated hemoglobin.
Pharmacokinetics
Mphamvu ya pharmacokinetic imadziwika ndi mawonekedwe a mayamwidwe, kugawa, kagayidwe ndi kutulutsa kwa zigawo zikuluzikulu:
- Mafuta Pambuyo kolowera, ziwalo za wothandizirazo zimatilira kwathunthu ndi makhoma am'mimba (m'mimba), ngakhale nthawi yakudya. Yambiri pazomera mutatenga chopanda kanthu m'mimba chimatha pambuyo 2 maola ndikuwonjezeka molingana ndi mlingo. Gawo la bioavailability mtheradi wa gawo lalikulu ndi 78%.
- Kugawa. Gawo lomwe limagwiritsa ntchito mankhwalawo lili pafupifupi 91% yomangidwa kumapuloteni. Matenda a impso kapena matenda a chiwindi sasokoneza chizindikiro ichi.
- Kupenda. Chofunikira chachikulu cha mankhwalawa ndi glucoside wokhala ndi mpweya wokhala ndi glucose, omwe amafotokozera kukana kwake ndi glucosidases. Zaka theka la moyo zomwe zimafunikira theka la moyo wa mankhwala opangidwa kuchokera ku madzi am'magazi anali maola 12.9 m'gulu lophunziridwa la odzipereka athanzi.
- Kupatula. Zigawo za mankhwala zimaperekedwa kudzera mu impso.
Nkhani ya kanema pa njira ya Forsig, gawo 1:
Zizindikiro ndi contraindication
Mankhwala sangathe kusintha glycemia ngati wodwalayo akupitiliza kudya zakudya zosafunikira.
Ichi ndichifukwa chake zakudya zamagulu olimbitsa thupi komanso kukhazikitsa zina zolimbitsa thupi ziyenera kukhala zofunikira pakuchiritsa. Forsig imatha kutumikiridwa ngati mankhwala okhawo othandizira, koma nthawi zambiri mapiritsi awa amalimbikitsidwa kuphatikiza ndi Metformin.
- kuwonda kwa odwala osadalira insulin,
- gwiritsani ntchito ngati mankhwala ena odwala odwala matenda ashuga,
- kukonza zakudya zomwe zimachitika pafupipafupi,
- kukhalapo kwa ma pathologies omwe amaletsa zolimbitsa thupi.
- Matenda a shuga a insulin.
- Mimba Contraindication amafotokozedwa ndi kusowa kwachidziwitso chotsimikizira chitetezo chogwiritsa ntchito panthawiyi.
- Nthawi yochepetsetsa.
- Zaka 75 ndi kupitilira. Izi zikuchitika chifukwa kuchepa kwa ntchito zomwe zimapangidwa ndi impso, komanso kuchepa kwa magazi.
- Lactose tsankho, yomwe ndi gawo lothandiza pamapiritsi.
- Zomwe zimapangitsa kuti utoto ugundane ndi utoto wa piritsi.
- Kukweza mulingo wa matupi a ketone.
- Nephropathy (wodwala matenda ashuga).
- Kulandila kwa okodzetsa ena, momwe amathandizidwira ndi munthawi yomweyo ndimapiritsi a Forsig.
- matenda opatsirana
- mowa, nikotini (palibe mayeso okhudzana ndi mankhwalawa omwe anachitika),
- kuchuluka hematocrit,
- matenda a kwamikodzo
- ukalamba
- kuvulala kwambiri kwa impso,
- kulephera kwa mtima.
Malangizo ogwiritsira ntchito
Mapiritsi amatengedwa pakamwa Mlingo womwe umadalira chithandizo chomwe amapatsa wodwala:
- Monotherapy. Mlingo sayenera kupitilira 10 mg patsiku.
- Kuphatikiza mankhwala. Tsiku lililonse, amaloledwa kutenga 10 mg ya Forsigi kuphatikiza ndi Metformin.
- Mankhwala oyambira ndi 500 mg a Metformin ndi 10 mg (kamodzi patsiku).
Kukonzekera kwamlomo wamankhwala sikudalira nthawi yakudya. Kuchepetsa mulingo wa mankhwalawa nthawi zambiri kumafunika ndi mankhwala a insulin kapena ndi mankhwala omwe amachititsa kuti achulukane.
Odwala omwe ali ndi matenda a impso kapena chiwindi ayenera kuyamba kumwa mapiritsi a 5 mg. M'tsogolomu, imatha kuwonjezeka mpaka 10 mg, malinga ngati zigawozo zimalekeredwa bwino.
Nkhani yavidiyo pa njira ya Forsig, gawo lachiwiri:
Odwala apadera
Mphamvu ya mankhwala imatha kusiyanasiyana ndi zina za wodwala kapena mawonekedwe:
- Matenda a impso. Kuchuluka kwa glucose yemwe amawonjezera mwachindunji kumatengera momwe ziwalozi zimagwirira ntchito.
- Pankhani yakuphwanya chiwindi, zotsatira za mankhwalawa zimasintha pang'ono, kotero, kusintha kwa Mlingo wokhazikitsidwa sikofunikira. Kupatuka kwakukuru mu zomwe zimagwiritsidwa ntchito zimawonedwa pokhapokha ngati pali matenda oopsa.
- M'badwo. Odwala osakwana zaka 70 sanawonetse kuwonekera kwakukulu.
- Okwatirana Pogwiritsa ntchito mankhwalawa, azimayi amapitilira AUC ndi 22% poyerekeza ndi amuna.
- Kuyanjana ndi mitundu sikumabweretsa kusiyana pakukhudzana kwatsatanetsatane.
- Kulemera. Odwala onenepa kwambiri anali ndi mfundo zotsika kwambiri panthawi yamankhwala.
Zotsatira za mankhwalawa kwa ana sizinaphunzire, kotero siziyenera kugwiritsidwa ntchito ngati chithandizo cha matendawa. Zoletsa zomwezo zimagwiranso ntchito kwa amayi apakati komanso oyamwitsa, popeza palibe chidziwitso chokhudza kulowa kwa zigawo za chinthucho kukhala mkaka.
Malangizo apadera
Mphamvu ya mankhwalawa zimatengera kupezeka kwa matenda okhudzana ndi matenda ashuga odwala:
- Matenda a impso. Nthawi zambiri, kuchepa kwa mphamvu yogwiritsa ntchito mankhwalawa kulibe mwa anthu omwe ali ndi vuto laling'onoting'ono la ziwalo. Woopsa mitundu ya mapiritsi, kumwa mapiritsi sangathe kutsogolera kwa achire zotsatira. Malangizo oterewa amafotokoza kufunika kosanthula kwa impso, komwe kumayenera kuchitika kangapo pachaka malinga ndi malangizo azachipatala.
- Matenda a chiwindi. Ndi kuphwanya koteroko, kuwonekera kwa chinthu chogwira ntchito chomwe ndi gawo la mankhwalawa kumatha kuchuluka.
Njira ya Forsig imabweretsa izi:
- kumaonjezera ngozi yochepetsera kuchuluka kwa magazi ozungulira,
- zimawonjezera mwayi wokwera ndi nkhawa,
- zimakhumudwitsa malire a electrolyte,
- chiopsezo chotenga matenda omwe amakhudza kwamkodzo thirakiti limawonjezeka
- ketoacidosis imatha kuchitika,
- kumawonjezera hematocrit.
Ndikofunikira kumvetsetsa kuti kumwa mapiritsi kuyenera kuchitika mutakambirana ndi dokotala.
Zotsatira zoyipa ndi bongo
Dapagliflozin amadziwika kuti ndi mankhwala otetezeka ndipo panthawi imodzi mapiritsi amodzi, opitilira muyeso wovomerezeka mwa nthawi 50, amalekeredwa bwino.
Kutsimikiza kwa mkodzo m'magazi kunawonedwa kwa masiku angapo, koma kuchepa kwa madzi, komanso kusokonekera kwa magazi ndi kusokonekera kwa electrolyte sizinapezeke.
M'magulu omwe aphunziridwa, momwe anthu ena adatenga Forsig ndipo enawo adatenga placebo, zochitika za hypoglycemia, komanso zochitika zina zoyipa, sizinasiyane kwambiri.
Kuchotsa chithandizo chamankhwala kuyenera kuchitika motere:
- creatinine kuchuluka
- pali matenda osiyanasiyana okhudza kwamikodzo,
- nseru zidawonekera
- mukumva chizungulire
- khungu litayamba
- matenda a chiwindi.
Ngati mankhwala osokoneza bongo apezeka, muyenera kukonza mankhwalawo poganizira thanzi lake.
Kodi nditha kuchepetsa thupi ndi Forsiga?
Mu malangizo a mankhwalawa, wopanga amawonetsa kuchepa kwa thupi komwe kumawonedwa pakumwa. Izi zimadziwika kwambiri kwa odwala omwe alibe matenda a shuga okha, komanso kunenepa kwambiri.
Chifukwa cha diuretic katundu, mankhwalawa amachepetsa kuchuluka kwa madzi mthupi. Kuthekera kwa zigawo zina za mankhwala kuphatikiza gawo la glucose kumathandizanso kuchepa kwa mapaundi owonjezera.
Mikhalidwe yayikulu yokwaniritsira kugwiritsa ntchito mankhwalawa ndiyosakwanira kudya komanso kuyambitsa zoletsa pazokhazokha malinga ndi zakudya zomwe zaperekedwa.
Anthu athanzi sayenera kugwiritsa ntchito mapiritsiwa kuti muchepetse kunenepa. Izi zimachitika chifukwa cha kuchuluka kwa impso, komanso kusadziwa bwino kwa Forsigi.
Kuyanjana Ndi Mankhwala Ndi Analogi
Mankhwalawa amathandizira kulimbitsa ma diuretics, insulin ndi mankhwala omwe amakulitsa chinsinsi chake.
Kugwiritsa ntchito bwino kwa mankhwalawa kumachepetsa pamene mukumwa mankhwalawa:
- Rifampicin,
- yogwira mtima chotengera,
- Ma enzyme omwe amalimbikitsa kagayidwe kazinthu zina.
Kudya kwa mapiritsi a Forsig ndi mefenamic acid kumawonjezera kufunikira kwa zinthu zogwira ndi 55%.
Forsiga ndi mankhwala okhawo omwe ali ndi Dapagliflozin omwe akupezeka ku Russia. Zina, zotsika mtengo za choyambirira sizipangidwa.
Njira ina ya mapiritsi a Forsig ingakhale mankhwala a glyphosine:
Maganizo a akatswiri ndi odwala
Kuchokera pakuwunika kwa madotolo ndi odwala za mankhwala a Forsig, titha kunena kuti mankhwalawa amachepetsa shuga m'magazi ndipo amathandizanso thupi lonse, komabe, ena amakhala ndi zovuta zoyipa, zomwe zimayenera kukumbukiridwa mukamamwa mankhwalawa.
Mankhwalawa adatsimikizira kugwira ntchito kwake poyeserera. Matenda a glycemia nthawi zambiri amatha kuchitika popanda zovuta. Odwala ena amasiya kubaya insulin. Izi zimatengedwa pazotsatira za kuyesa komwe anthu 50,000 omwe anali ndi glycemia ochokera 10 mmol / l adatenga nawo gawo. Kuphatikiza pakukhazikitsa shuga, mankhwalawa anali ndi phindu pa thanzi lathunthu.
Alexander Petrovich, endocrinologist
Forsyga ndi mankhwala oyamba m'gululi la zoletsa zatsopano. Mphamvu za mankhwalawa sizodalira ntchito ya maselo a beta, komanso insulin. Zigawo zomwe zimagwira zimalepheretsa kugwedezeka kwa glucose m'm impso, potero zimachepetsa mfundo zake m'magazi.Mapindu ofunikanso ndikuchepetsa thupi ndi kuchepetsa mwayi wa hypoglycemia. Mayeso awonetsa kuti chithandizo sichiri chotsatira limodzi. Mankhwalawa agwiritsidwa ntchito mwanzeru kunja kwazaka zingapo, komwe kwatsimikizira kugwira ntchito kwake mobwerezabwereza.
Irina Pavlovna, endocrinologist
Mapiritsi a Forsig adalembedwa kwa amayi anga pambuyo pokana insulin. Panthawi yoyambira kudya, pafupifupi mayendedwe onse a amayi anga sanali zachilendo. C-peptide inali pansi pa malire ovomerezeka, ndipo shuga, m'malo mwake, anali pafupifupi 20. Patatha masiku anayi piritsi loyamba litatengedwa, kusintha kwadziwika. Shuga anasiya kutuluka pamwamba pa 10, ngakhale anali ndi Mlingo wambiri wamankhwala ena (Amaril, Siofor). Patatha mwezi umodzi ndimankhwala awa, mankhwala ambiri adathetsedwa chifukwa cha mayi. Ndinganene kuti ngakhale njira za Forsig ndizokhutira kwambiri.
Ndinawerenga ndemanga kuchokera kwa ogwiritsa ntchito ena ndipo ndimadabwa. Mankhwalawa adathandiza ambiri, koma osati ine. Chiyambireni chakumwa chake, shuga anga sanangobwerera kokha, komanso adalumpha. Koma choyipa kwambiri ndikumayamwa kumamveka mthupi lonse, komwe sikungatheke. Ndikhulupilira kuti mankhwala omwe ali ndi mavuto ngati amenewa sayenera kugwiritsidwa ntchito ndi aliyense.
Mtengo wa phukusi la Forsig la mapiritsi 30 (10 mg) ndi pafupifupi ma ruble 2600.
Kuphatikizika kosiyanasiyana, kungagwirizane mukuwonetsa komanso momwe mungagwiritsire ntchito
| Mutu | Mtengo ku Russia | Mtengo ku Ukraine |
|---|---|---|
| Rosiglitazone wothandiza, metformin hydrochloride | -- | -- |
| Bagomet Metformin | -- | 30 UAH |
| Glucofage metformin | 12 rub | 15 UAH |
| Glucophage xr metformin | -- | 50 UAH |
| Reduxin Met Metformin, Sibutramine | 20 rub | -- |
| Dianormet | -- | 19 UAH |
| Diaformin metformin | -- | 5 UAH |
| Metformin metformin | 13 rub | 12 UAH |
| Metformin sandoz metformin | -- | 13 UAH |
| Siofor | 208 rub | 27 UAH |
| Fomu metformin hydrochloride | -- | -- |
| Emnorm EP Metformin | -- | -- |
| Megifort Metformin | -- | 15 UAH |
| Metamine Metformin | -- | 20 UAH |
| Metamine SR Metformin | -- | 20 UAH |
| Metfogamma metformin | 256 rub | 17 UAH |
| Tefor metformin | -- | -- |
| Glycometer | -- | -- |
| Glycomet SR | -- | -- |
| Forethine | 37 rub | -- |
| Metformin Canon metformin, ovidone K 90, wowuma chimanga, crospovidone, magnesium stearate, talc | 26 rub | -- |
| Insuffor metformin hydrochloride | -- | 25 UAH |
| Metformin-teva metformin | 43 rub | 22 UAH |
| Diaformin SR metformin | -- | 18 UAH |
| Mepharmil Metformin | -- | 13 UAH |
| Metformin Farmland Metformin | -- | -- |
| Glibenclamide Glibenclamide | 30 rub | 7 UAH |
| Maninyl Glibenclamide | 54 rub | 37 UAH |
| Glibenclamide-Health Glibenclamide | -- | 12 UAH |
| Glyurenorm glycidone | 94 rub | 43 UAH |
| Bisogamma Glyclazide | 91 rub | 182 UAH |
| Glidiab Glyclazide | 100 rub | 170 UAH |
| Diabeteson MR | -- | 92 UAH |
| Diagnizide mr Gliclazide | -- | 15 UAH |
| Glidia MV Gliclazide | -- | -- |
| Glykinorm Gliclazide | -- | -- |
| Gliclazide Gliclazide | 231 rub | 57 UAH |
| Glyclazide 30 MV-Indar Glyclazide | -- | -- |
| Glyclazide-Health Gliclazide | -- | 36 UAH |
| Glioral Glyclazide | -- | -- |
| Diagnizide Gliclazide | -- | 14 UAH |
| Diazide MV Gliclazide | -- | 46 UAH |
| Osliklid Gliclazide | -- | 68 UAH |
| Diadeon gliclazide | -- | -- |
| Glyclazide MV Gliclazide | 4 rub | -- |
| Amaril | 27 rub | 4 UAH |
| Glemaz glimepiride | -- | -- |
| Glian glimepiride | -- | 77 UAH |
| Glimepiride Glyride | -- | 149 UAH |
| Glimepiride diapiride | -- | 23 UAH |
| Guwa | -- | 12 UAH |
| Glimax glimepiride | -- | 35 UAH |
| Glimepiride-Lugal glimepiride | -- | 69 UAH |
| Clay glimepiride | -- | 66 UAH |
| Diabrex glimepiride | -- | 142 UAH |
| Meglimide glimepiride | -- | -- |
| Melpamide Glimepiride | -- | 84 UAH |
| Perinel glimepiride | -- | -- |
| Glempid | -- | -- |
| Wokongola | -- | -- |
| Glimepiride glimepiride | 27 rub | 42 UAH |
| Glimepiride-teva glimepiride | -- | 57 UAH |
| Glimepiride Canon glimepiride | 50 rub | -- |
| Glimepiride Pharmstandard glimepiride | -- | -- |
| Dimaril glimepiride | -- | 21 UAH |
| Glamepiride diamerid | 2 rub | -- |
| Amaryl M Limepiride Micronized, Metformin Hydrochloride | 856 rub | 40 UAH |
| Glibomet glibenclamide, metformin | 257 rub | 101 UAH |
| Glucovans glibenclamide, metformin | 34 rub | 8 UAH |
| Dianorm-m Glyclazide, Metformin | -- | 115 UAH |
| Dibizid-m glipizide, metformin | -- | 30 UAH |
| Douglimax glimepiride, metformin | -- | 44 UAH |
| Duotrol glibenclamide, metformin | -- | -- |
| Gluconorm | 45 rub | -- |
| Glibofor metformin hydrochloride, glibenclamide | -- | 16 UAH |
| Avandamet | -- | -- |
| Avandaglim | -- | -- |
| Janumet metformin, sitagliptin | 9 rub | 1 UAH |
| Velmetia metformin, sitagliptin | 6026 rub | -- |
| Galvus Met vildagliptin, metformin | 259 rub | 1195 UAH |
| Tripride glimepiride, metformin, pioglitazone | -- | 83 UAH |
| Comboglize XR metformin, saxagliptin | -- | 424 UAH |
| Comboglyz Prolong metformin, saxagliptin | 130 rub | -- |
| Gentadueto linagliptin, metformin | -- | -- |
| Vipdomet metformin, alogliptin | 55 rub | 1750 UAH |
| Sinjardi empagliflozin, metformin hydrochloride | 240 rub | -- |
| Voglibose Oxide | -- | 21 UAH |
| Glutazone pioglitazone | -- | 66 UAH |
| Dropia Sanovel pioglitazone | -- | -- |
| Januvia sitagliptin | 1369 rub | 277 UAH |
| Galvus vildagliptin | 245 rub | 895 UAH |
| Onglisa saxagliptin | 1472 rub | 48 UAH |
| Nesina alogliptin | -- | -- |
| Vipidia alogliptin | 350 rub | 1250 UAH |
| Trazhenta linagliptin | 89 rub | 1434 UAH |
Kodi mungapeze bwanji analogue yotsika mtengo ya mankhwala okwera mtengo?
Kuti mupeze chiwonetsero chotsika mtengo cha mankhwala, chofananira kapena chofanana, choyambirira timalimbikitsa kulabadira kapangidwe kake, zomwe ndi zinthu zomwezo zomwe zikugwira komanso zomwe zikugwiritsidwa ntchito. Zomwe zimagwiritsidwanso mosiyanasiyana ndi mankhwalawa zimawonetsa kuti mankhwalawo ndi ofanana ndi mankhwalawo, monga mankhwala ena kapena mitundu ina. Komabe, musaiwale za zovuta zomwe zimagwiritsidwa ntchito ndi mankhwala ofanana, omwe angakhudze chitetezo ndi kugwiranso ntchito. Musaiwale za malangizo a madotolo, kudzipereka nokha kungawononge thanzi lanu, chifukwa chake onani dokotala wanu musanagwiritse ntchito mankhwala.
Malangizo a Forsig
Fomu ya Mlingo:
mapiritsi okhala ndi filimu
Kupanga
Piritsi limodzi lokhazikika mu 5 mg, lili ndi:
Chithandizo:
dapagliflozin propanediol monohydrate 6.150 mg, yowerengeka pa dapagliflosin 5 mg
Omwe amathandizira: cellcrystalline cellulose 85.725 mg, anactrous lactose 25,000 mg, crospovidone 5,000 mg, silicon dioxide 1,875 mg, magnesium stearate 1,250 mg,
Chipolopolo cha piritsi: Opadray® II chikasu 5,000 mg (polyvinyl mowa pang'ono hydrolyzed 2,000 mg, titanium dioxide 1,177 mg, macrogol 3350 1,010 mg, talc 0,740 mg, utoto wa iron oxide chikasu 0,073 mg).
Piritsi limodzi lokhathamira 10 mg lili ndi:
Chithandizo:
dapagliflosin propanediol monohydrate 12,30 mg, kuwerengeka ngati dapagliflosin 10 mg
Omwe amathandizira: microcrystalline cellulose 171.45 mg, anactrous lactose 50.00 mg, crospovidone 10.00 mg, silicon dioxide 3.75 mg, magnesium stearate 2.50 mg,
Chipolopolo cha piritsi: Opadray® II chikasu 10,00 mg (mowa wa polyvinyl pang'ono hydrolyzed 4.00 mg, titanium dioxide 2.35 mg, macrogol 3350 2.02 mg, talc 1.48 mg, utoto wa ayoni wachikasu 0.15 mg) .
Kufotokozera
Mapiritsi a 5 mg okhala ndi mafilimu:
Mapiritsi ozungulira a biconvex atakulungidwa ndi nembanemba wachikasu, olembedwa "5" mbali imodzi ndi "1427" mbali inayo.
Mapiritsi okhala ndi filimu, 10 mg:
Mapiritsi a Rhomboid biconvex opakidwa utoto wachikasu wachikaso, olembedwa "10" mbali imodzi ndi "1428" mbali inayo.
Gulu la Pharmacotherapeutic
Hypoglycemic wothandizira pakamwa - lembani 2 glucose transporter inhibitor
Code ya ATX: A10BX09
Mankhwala
Njira yamachitidwe
Dapagliflozin ndi potent (Kihibitilamu wosasinthika (Ki) wa 0,55 nM), mtundu wosankha-mtundu 2 wa glucose cotransporter inhibitor (SGLT2). SGLT2 imawonetsedwa moyenera mu impso ndipo sapezeka m'matumbo ena opitilira 70 (kuphatikizanso chiwindi, minofu yamatumbo, minofu ya adipose, gland ya mammary, chikhodzodzo, ndi ubongo). SGLT2 ndiye chonyamula chachikulu cha glucose reabsorption mu aimpso tubules. Glucose reabsorption mu aimpso tubules kwa odwala omwe ali ndi matenda a shuga 2 mellitus (T2DM) akupitiliza ngakhale hyperglycemia. Mwa kuletsa kusinthika kwa impso m'magazi, dapagliflozin imachepetsa kugwedezeka kwa impso tubules, zomwe zimapangitsa kuti shuga akhale impso. Zotsatira za dapagliflozin ndikuchepa kwa glucose othamanga ndipo mutatha kudya, komanso kuchepa kwa kuchuluka kwa hemoglobin ya glycosylated kwa odwala omwe ali ndi matenda a shuga a 2.
Kuchotsa glucose (glucosuric athari) kumachitika mutamwa mankhwala oyamba, umapitirira kwa maola 24 otsatira ndikupitilira chithandizo chonse. Kuchuluka kwa shuga komwe impso zimapangidwa chifukwa cha njirayi kumadalira kuchuluka kwa shuga m'magazi komanso kuchuluka kwa kusefedwa kwa glomerular (GFR). Dapagliflozin sichimasokoneza kupanga kwachilendo kwa glucose amkati poyankha hypoglycemia. Zotsatira za dapagliflozin ndizodziyimira payekha paz insulin komanso insulin sensitivity. M'maphunziro azachipatala a Forsig ™, kusintha kwa beta-cell kunadziwika (kuyesedwa kwa HOMA, kuwunika kwa homeostasis).
Kuwonongeka kwa shuga ndi impso zomwe zimayambitsidwa ndi dapagliflozin limodzi ndi kuchepa kwa zopatsa mphamvu komanso kuchepa kwa thupi. Dapagliflozin zoletsa wa sodium glucose cotransport limodzi ndi ofooka okodzetsa ndi osakhalitsa natriuretic zotsatira.
Dapagliflozin ilibe gawo lililonse kwa anthu ena omwe amayendetsa glucose omwe amayenda ndi glucose kuzinthu zotumphukira ndikuwonetsa kupitirira 1,400 nthawi yayikulu pakusankha kwa SGLT2 kuposa SGLT1, transporter yayikulu m'matumbo omwe amayambitsa kuyamwa kwa glucose.
Mankhwala
Atamwa dapagliflozin ndi odzipereka athanzi komanso odwala matenda amtundu wa 2, kuwonjezeka kwa glucose komwe anapatsidwa ndi impso kunawonedwa. Pamene dapagliflozin amatengedwa pa mlingo wa 10 mg / tsiku kwa masabata 12, mwa odwala T2DM, pafupifupi 70 g ya shuga patsiku idachotsedwa ndi impso (zomwe zimafanana ndi 280 kcal / tsiku). Odwala omwe ali ndi matenda a shuga a mtundu wa 2 omwe adatenga dapagliflozin pa 10 mg / tsiku kwa nthawi yayitali (mpaka zaka ziwiri), shuga wa mayamwidwe adasungidwa panthawi yonse ya mankhwala.
Kuchulukanso kwa shuga kwa impso ndi dapagliflozin kumathandizanso kuti osmotic diuresis ndi kuchuluka kwa mkodzo kuchuluka. Kuwonjezeka kwa kuchuluka kwa mkodzo kwa odwala omwe ali ndi matenda amtundu wa 2 akumamwa dapagliflozin pa 10 mg / tsiku lokhalokha kwa masabata 12 ndipo limafikira pafupifupi 375 ml / tsiku. Kuchuluka kwa kuchuluka kwa mkodzo kumayendera limodzi ndi kuchepa kwa pang'onopang'ono kwa impso, komwe sikunapangitse kusintha kwa kuchuluka kwa sodium mu seramu yamagazi.
Pharmacokinetics
Mafuta
Pambuyo pakukonzekera pakamwa, dapagliflozin imatengedwa mwachangu komanso kwathunthu m'matumbo am'mimba ndipo imatha kutengedwa nthawi yonse ya chakudya komanso kunja kwake. Kuchuluka kwa dapagliflozin m'madzi am'magazi (Stax) nthawi zambiri kumachitika mkati mwa maola 2 mutatha kudya. Makhalidwe a Cmax ndi AUC (dera lomwe lili pansi pa nthawi yopondera) amawonjezeka molingana ndi mlingo wa dapagliflozin. Mtheradi bioavailability wa dapagliflozin akaperekedwa pakamwa pa 10 mg ndi 78%. Kudya kunali ndi zolimbitsa pa pharmacokinetics ya dapagliflozin mwa odzipereka athanzi. Zakudya zamafuta kwambiri zimachepetsa Stax ya dapagliflozin ndi 50%, idakulitsa Ttah (nthawi yofika ndende yambiri ya plasma) pafupifupi ola limodzi, koma sizinakhudze AUC poyerekeza ndi kusala kudya. Kusintha kumeneku sikofunikira pachipatala.
Kugawa
Dapagliflozin pafupifupi 91% amamangidwa kumapuloteni. Odwala omwe ali ndi matenda osiyanasiyana, mwachitsanzo, omwe ali ndi vuto laimpso kapena kwa chiwindi, chizindikiro ichi sichinasinthe.
Kupenda
Dapagliflozin ndi glucoside yolumikizidwa ndi C yomwe aglycon yake imalumikizidwa ndi glucose ndi chomangira cha mpweya woipa (carbon-carbon bond), chomwe chimatsimikizira kukhazikika kwake pakulimbana ndi glucosidases. Wapakati wama plasma hafu ya moyo (T½) mwa odzipereka athanzi anali 12,9 patatha ola limodzi dapagliflozin pakamwa pa 10 mg. Dapagliflozin imapangidwa kuti ipange metabolite yosagwira kwambiri ya dapagliflozin-3-O-glucuronide.
Pambuyo pakamwa 50 mg ya 14C-dapagliflozin, 61% ya mlingo womwe unatengedwa umapangidwira dapagliflozin-3-O-glucuronide, womwe umakhala ndi 42% ya kuchuluka kwa plasma radioacaction (maola AUC0-12) - Mankhwala osasinthika amakhala ndi 39% ya kuchuluka kwa plasma ya plasma. Zigawo za metabolites zomwe zatsala payekhapayekha sizidutsa 5% ya kuchuluka kwa madzi am'magazi. Dapagliflozin-3-O-glucuronide ndi ma metabolites ena alibe mankhwala. Dapagliflozin-3-O-glucuronide imapangidwa ndi enzyme uridine diphosphate-glucuronosyltransferase 1A9 (UGT1A9) yomwe ilipo m'chiwindi ndi impso, ndipo ma CYP cytochrome isoenzymes sakukhudzidwa ndi metabolism.
Kuswana
Dapagliflozin ndi ma metabolites ake amachotsedwa makamaka ndi impso, ndipo ndi ochepera 2% omwe amachotsedwa osasinthika. Mutatenga 50 mg ya 14C-dapagliflozin, 96% ya radioacaction idapezeka - 75% mkodzo ndi 21% mu ndowe. Pafupifupi 15% ya ma radioac opezeka mu ndowe adawerengedwa ndi dapagliflozin.
Pharmacokinetics mwapadera matenda
Odwala ndi mkhutu aimpso ntchito
Pa equilibrium (ndikutanthauza AUC), kuwonekera kwadongosolo kwa dapagliflozin odwala omwe ali ndi matenda a shuga a 2 komanso ofatsa, ochepa, kapena kulephera kwambiri kwa impso (monga momwe iohexol chilolezo) anali 32%, 60%, ndi 87% kuposa omwe amapezeka ndi odwala matenda a shuga 2 impso, motero. Kuchuluka kwa shuga kwa impso masana mutatenga dapagliflozin mu ofanana kumadalira boma la impso. Odwala omwe ali ndi matenda a shuga a mtundu wachiwiri ndi aimpso kugwira ntchito, komanso mofatsa, pang'ono kapena pang'ono, aimpso, 85, 52, 18 ndi 11 ga glucose adachotsedwera patsiku, motero. Panalibe kusiyana pakumanga kwa dapagliflozin kupangira mapuloteni mu odzipereka athanzi komanso odwala omwe amalephera kupweteka aimpso. Sizikudziwika ngati hemodialysis imakhudzana ndi mawonekedwe a dapagliflozin.
Odwala omwe ali ndi vuto la chiwindi
Odwala omwe ali ndi kuchepa pang'ono kapena kosakwanira kwa hepatic, kuchuluka kwa Cmax ndi AUC ya dapagliflozin anali 12% ndi 36% apamwamba, motsatana, poyerekeza ndi odzipereka athanzi. Kusiyana kumeneku sikofunikira kuchipatala, motero kusintha kwa dapagliflozin mwa odwala omwe ali ndi vuto lochepa la chiwindi sikofunikira (onani gawo "Mlingo ndi Ulamuliro"). Cmax ndi AUC ya dapagliflozin anali 40% ndi 67% apamwamba, motero, poyerekeza ndi odzipereka athanzi.
Okalamba okalamba (> wazaka 65)
Panalibe kuwonjezeka kwakadwala kovuta kwambiri kwa odwala omwe ali ndi zaka zosakwana 70 (pokhapokha ngati zifukwa zina sizakukhudzidwa). Komabe, kuwonjezeka kwawonetsero kungayembekezeredwe chifukwa kuchepa kwa ntchito yaimpso yolumikizidwa ndi zaka. Zambiri zowonekera kwa odwala azaka zopitilira 70 ndizosakwanira.
Okwatirana
Mwa akazi, AUC wamba pamlingo wofanana ndi 22% kuposa kuposa amuna.
Mtundu
Palibe kusiyana kwakukulu pakumwonekera kwatsatanetsatane komwe kunapezeka pakati pa oimira amipikisano ya Caucasian, Negroid ndi Mongoloid.
Kulemera kwa thupi
Makhalidwe otsika kwambiri ndi kulemera kwamphamvu kwa thupi adadziwika. Chifukwa chake, mwa odwala omwe ali ndi thupi lozama, kuwonekera pang'ono kungadziwike, ndipo mwa odwala omwe ali ndi thupi lochulukirapo - kuchepa kwa chiwonetsero cha dapagliflozin. Komabe, kusiyana kumeneku sikofunikira mwamaganizidwe.
Zizindikiro zogwiritsidwa ntchito
Type 2 shuga mellitus kuwonjezera pa zakudya ndi masewera olimbitsa thupi kuti muthe kuwongolera glycemic control:
monotherapy
zowonjezera zamankhwala a metformin pakakhala kuti palibe chidziwitso chokwanira cha mankhwalawa.
kuyamba kuphatikiza mankhwala ndi metformin, ngati mankhwalawa alangizidwa.
Contraindication
Kuchulukitsa chidwi kwa munthu aliyense pazinthu zilizonse za mankhwala.
Mtundu woyamba wa shuga.
Matenda a shuga ketoacidosis.
Kulephera kwamphamvu komanso kwakali konse (GFR zaka 65)
Zotsatira zoyipa zomwe zimakhudzana ndi kuwonongeka kwa impso kapena kulephera kwa aimpu zidanenedwa mwa 2,5% ya odwala omwe amalandila dapagliflozin, ndipo mu 1.1% ya odwala omwe akulandira placebo pagulu la odwala> azaka 65 (onani gawo "Malangizo Apadera"). Nthawi zambiri zoyipa zomwe zimakhudzana ndi vuto laimpso zinali kuwonjezeka kwa serum creatinine ndende. Zambiri mwanjira izi zinali zakanthawi komanso zosintha. Mwa odwala azaka zapakati pa 65, kuchepa kwa BCC, komwe nthawi zambiri kumalembetsa mozungulira, kumawonedwa mu 1.5% ndi 0.4% ya odwala omwe akutenga dapagliflozin ndi placebo, motero (onani gawo "Special Instructions"),
Bongo
Dapagliflozin ndiyotetezeka komanso yolekeredwa bwino ndi odzipereka athanzi limodzi ndi mlingo umodzi wofika 500 mg (50 nthawi ya mlingo woyenera). Glucose anali kutsimikiza mu mkodzo atamwa mankhwalawa (osachepera masiku 5 atatha kumwa 500 mg), pomwe kunalibe milandu yakusowa magazi, kuchepa kwa magazi, kusalinganika kwa electrolyte, kukhudzidwa kwakukulu pakubwera kwa QTc. Zovuta za hypoglycemia zinali zofanana ndi pafupipafupi ndi placebo. M'maphunziro azachipatala odzipereka omwe ali ndi thanzi labwino komanso odwala omwe ali ndi matenda a shuga 2 omwe adamwa mankhwalawo kamodzi mpaka 100 mg (kakhumi mopitilira muyeso wabwino kwambiri) kwa masabata awiri, vuto la hypoglycemia lidakwera pang'ono kuposa ndi placebo, ndipo silinadalire mlingo . Zomwe zimachitika pazochitika zoyipa, kuphatikiza kuchepa kwa madzi m'thupi kapena kuchepa kwa thupi, zinali zofanana ndi pafupipafupi pagulu la placebo, popanda kusintha kwakukulu kokhudzana ndi kuchuluka kwa magawo a labotale, kuphatikiza ma seramu ambiri a ma elekitirodiya ndi ma biomarkers a ntchito ya impso.
Pankhani ya bongo, ndikofunikira kuchita kukonza mankhwala, kuganizira momwe wodwalayo alili. Kutulutsa kwa dapagliflozin ndi hemodialysis sikunaphunzire.
Kuchita ndi mankhwala ena
Zodzikongoletsera
Dapagliflozin imatha kupititsa patsogolo okodzetsa a thiazide ndi "loop" okodzetsa ndikukulitsa chiwopsezo cha kuchepa thupi komanso kuthana ndi vuto lokhala ndi ziwongo (onani "Maupangiri Apadera").
Kuchita kwa Pharmacokinetic
Kagayidwe ka dapagliflozin imachitika makamaka kudzera mu glucuronide conjugation mothandizidwa ndi UGT1A9.
Mu maphunziro a in vitro, dapagliflozin sizinatsekerere isoenzymes ya cytochrome P450 system CYP1A2, CYP2A6, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6, CYP3A4, ndipo sanalowetsetsetsetse. Mwakutero, zotsatira za dapagliflozin pakuvomerezeka kwa metabolic a concomitant mankhwala omwe amapangidwa ndi izienzymes sizikuyembekezeredwa.
Zotsatira za mankhwala ena pa dapagliflozin
Kafukufuku wokhudzana ndi odzipereka omwe ali ndi thanzi labwino, makamaka omwe adamwa kamodzi pa mankhwalawa, adawonetsa kuti metformin, pioglitazone, sitagliptin, glimepiride, voglibose, hydrochlorothiazide, bumetanide, valsartan kapena simvastatin sizikhudza pharmacokinetics ya dapagliflosin. Pambuyo pa kuphatikiza kwa dapagliflozin ndi rifampicin, wolimbikitsa maulendo osiyanasiyana okhathamiritsa ndi ma enzyme omwe amapangitsa kuti mankhwala azigwiritsa ntchito, a systemation exposition (AUC) ya dapagliflozin amachepetsedwa ndi 22%, pakalibe zotsatira zazikulu pakuwona kwa shuga kwa impso tsiku ndi tsiku. Sikulimbikitsidwa kusintha mlingo wa mankhwalawa. Zotsatira zazikulu zamankhwala zikagwiritsidwa ntchito ndi inducers zina (mwachitsanzo carbamazepine, phenytoin, phenobarbital) sizimayembekezeredwa.
Pambuyo pakuphatikizidwa kwa dapagliflozin ndi mefenamic acid (UGT1A9 inhibitor), kuwonetsa kwa chiwonetsero cha dapagliflozin kwamtundu wa 55%, koma popanda chiwonetsero chachikulu cha kupezeka kwa shuga kwa impso tsiku ndi tsiku. Sikulimbikitsidwa kusintha mlingo wa mankhwalawa.
Zotsatira za dapagliflozin pa mankhwala ena
Pakufufuza komwe kudachitika odzipereka athanzi labwino, makamaka kumwa kamodzi pa mankhwalawo, dapagliflozin sizinakhudze pharmacokinetics ya metformin, pioglitazone, sitagliptin, glimepiride, hydrochlorothiazide, bumetanide, valsartan, digoxin (gawo lapansi la Varifarf, kapena isoenzyme CYP2C9), kapena pa anticoagulant zotsatira, zoyesedwa ndi International Normalized Ratio (MHO). Kugwiritsa ntchito mlingo umodzi wa dapagliflozin 20 mg ndi simvastatin (gawo laling'ono la CYP3A4 isoenzyme) kunapangitsa kuchuluka kwa 19% ya simvastatin AUC ndi 31% simvastatin acid AUC. Kuchuluka kwa simvastatin ndi simvastatin acid sikumveka kwakukulu.
Zochita zina
Mavuto obwera chifukwa cha kusuta, zakudya, mankhwala azitsamba, komanso kumwa mowa pa pharmacokinetics ya dapagliflozin sizinaphunzire.
Malangizo apadera
Gwiritsani ntchito odwala omwe ali ndi vuto laimpso
Kugwiritsa ntchito kwa dapagliflozin kumadalira ntchito yaimpso, ndipo izi zimachepetsedwa mwa odwala omwe amalephera kupweteka aimpso ndipo mwina sapezeka mwa odwala omwe amalephera kwambiri aimpso (onani gawo "Mlingo ndi Administration"). Mwa odwala omwe ali ndi vuto lochepetsa aimpso (CC wazaka 65, kuchuluka kwakukulu kwa odwala omwe amalandila dapagliflozin) kunachitika mosakhudzidwa komwe kumayenderana ndi kuperewera kwaimpso kapena kulephera kwaimpso poyerekeza ndi placebo. kuchuluka kwa ma serum creatinine, nthawi zambiri anali osakhalitsa komanso osintha (onani gawo "Zotsatira zoyipa").
Kwa odwala okalamba, chiwopsezo cha kuchepa kwa BCC chingakhale chambiri, ndipo okodzetsa amakhala ndi mwayi wotengedwa. Mwa odwala omwe ali ndi zaka 65 - 65, odwala ochulukirapo omwe adalandira dapagliflozin adakumana ndi zovuta zomwe zimakhudzana ndi kuchepa kwa BCC (onani gawo "Zotsatira zoyipa").
Zomwe amagwiritsa ntchito mankhwalawa kwa odwala azaka 75 ndi akulu ndizochepa. Amakanizidwa kuti ayambe kugwiritsa ntchito mankhwala a dapagliflozin mwa anthuwa (onani zigawo "Mlingo ndi Ulamuliridwe" ndi "Pharmacokinetics").
Kulephera kwamtima kosalekeza
Zomwe zidachitika ndi mankhwalawa kwa odwala omwe ali ndi vuto la mtima la I-II gulu logwirira ntchito molingana ndi gulu la NYHA ndilochepa, ndipo pazoyesa zamankhwala, dapagliflozin sanagwiritsidwe ntchito mwa odwala omwe ali ndi vuto la mtima la III-IV kalasi yogwira ntchito malinga ndi NYHA.
Kuchuluka kwa hematocrit
Mukamagwiritsa ntchito dapagliflozin, kuwonjezereka kwa hematocrit kunawonedwa (onani gawo "Zotsatira zoyipa"), chifukwa chake ayenera kusamala mwa odwala omwe ali ndi kuchuluka kwa hematocrit.
Kuyesa kwa mayeso a mkodzo
Chifukwa cha mapangidwe ake a mankhwalawa, zotsatira za kusanthula kwamkodzo kwa glucose mwa odwala omwe atenga Forsig ™ adzakhala abwino.
Zokhudza mphamvu pakutha kuyendetsa magalimoto ndi zida
Kafukufuku wofufuza momwe mphamvu ya dapagliflozin ikuyendera magalimoto ndi njira sizinachitike.
Kutulutsa Fomu
Mapiritsi okhala ndi mafilimu, 5 mg, 10 mg.
Mapiritsi 14 okhala ndi matuza a aluminium zojambulazo, matuza awiri kapena anayi mu bokosi la makatoni okhala ndi malangizo ogwiritsira ntchito, kapena mapiritsi 10 ali ndi matuza a aluminiyamu zojambulazo, matuza atatu kapena 9 osungika mu bokosi la makatoni okhala ndi malangizo ogwiritsira ntchito.
Malo otseguka a mtolo wa makatoni amatsekedwa ndi zikwangwani ziwiri zoteteza khungu, pakatikati pa chosindikizira chilichonse, chokhala ndi mizere ya misozi, imayikidwa njira ya mauna achikasu.
Tsiku lotha ntchito
Zaka zitatu
Osagwiritsa ntchito tsiku lotha ntchito likusonyezedwa pa phukusi.
Malo osungira
Kutentha kopitilira 30 ° C, m'malo osafikirika ndi ana.
Pewani kufikira ana.
Migwirizano ya Tchuthi
Ndi mankhwala.
Wopanga
Bristol Myers squibb Manufaking Company, Puerto Rico
Road 3, Km. 77.5, PO Box 609, Humacao, PR-00791, Puerto Rico
Bristol-Myers squibb Production Company
Road 3, Km 77.5, Box Box 609, Humacao, PR-00791, Puerto Rico
Tchulani ndi adilesi ya bungwe lalamulo lomwe chikalata chake cholembedwa chikuperekedwa
Bristol Myers squibb Company, USA
345, Park Avenue, New York, NY, USA
Bristol-Myers squibb Company, USA
345, Park Avenue, New York, New York, USA
Mndandanda wa mankhwala Forsig
Analogue ndiyotsika mtengo kuchokera ku ma ruble a 1908.
Jardins ndi mankhwala achilendo wochizira matenda amtundu wa 2. Empagliflozin mu 25 mg piritsi lililonse limagwira ntchito ngati gawo limodzi lokhazikika. Jardins ali ndi contraindication ndi zoletsa zaka, motero funsani ndi dokotala musanayambe chithandizo.
Analogue ndiyotsika mtengo kuchokera ku ma ruble a 1967.
Wopanga: Novo Nordisk (Denmark)
Kutulutsa Mafomu:
- Tab. 1 mg, ma PC 30., Mtengo kuchokera 175 ma ruble
- Tab. 2 mg, ma PC 30., Mtengo kuchokera ku ma ruble 219
Malangizo ogwiritsira ntchito
NovoNorm ndimakonzedwe a piritsi kuchokera ku gulu lomwelo lamankhwala, koma pogwiritsa ntchito njira ina. Repaglinide imagwiritsidwa ntchito pano pa mulingo wa 0,5 mpaka 2 mg. Zizindikiro zakupangira zikufanana, koma ma contraindication amasiyana chifukwa cha ma DV osiyanasiyana pamapiritsi, kotero werengani malangizo mosamala ndikuwonana ndi dokotala.
Analogue ndiyotsika mtengo kuchokera ku ma ruble a 1908.
Wopanga: Akrikhin (Russia)
Kutulutsa Mafomu:
- Tab. 1 mg, ma PC 30., Mtengo kuchokera 234 ma ruble
- Tab. 2 mg, ma PC 30., Mtengo kuchokera ku ma ruble 219
Malangizo ogwiritsira ntchito
Novo Nordisk (Denmark) NovoNorm ndi piritsi lokonzekera kuchokera ku gulu lomwelo lamankhwala, koma lokhala ndi chinthu china. Repaglinide imagwiritsidwa ntchito pano pa mulingo wa 0,5 mpaka 2 mg. Zizindikiro zakupangira zikufanana, koma ma contraindication amasiyana chifukwa cha ma DV osiyanasiyana pamapiritsi, kotero werengani malangizo mosamala ndikuwonana ndi dokotala.
Analogue ndiokwera mtengo kwambiri kuchokera ku ma ruble 311.
Wopanga: Ikufotokozedwa
Kutulutsa Mafomu:
- Tab. tsa / obol. 100 mg, 30 ma PC., Mtengo kuchokera 2453 rubles
- Tab. 2 mg, ma PC 30., Mtengo kuchokera ku ma ruble 219
Malangizo ogwiritsira ntchito
Novo Nordisk (Denmark) NovoNorm ndi cholowa m'malo mwa Forsigi. Chokhacho chomwe chimagwira ntchito mankhwalawa ndi repaglinide. Mankhwala mkati mphindi 30 kumawonjezera insulin ndende mu magazi. Chifukwa chosowa deta pamaphunziro omwe amachitika pachitetezo cha mankhwalawa komanso kugwiritsa ntchito bwino mapiritsi pagulu la ana, sizikulimbikitsidwa kuti mugwiritse ntchito mankhwalawa kwa ana osakwana zaka 18. Mwanjira yonyansa, kutsegula m'mimba ndi kupweteka pamimba nthawi zambiri kumachitika.
Ma Forsigi Tablet Replacers
NovoNorm (mapiritsi) Kutalika: 152
Analogue ndiyotsika mtengo kuchokera ku ma ruble a 1967.
NovoNorm ndi cholowa m'malo mwa Forsigi. Chokhacho chomwe chimagwira ntchito mankhwalawa ndi repaglinide. Mankhwala mkati mphindi 30 kumawonjezera insulin ndende mu magazi. Chifukwa chosowa deta pamaphunziro omwe amachitika pachitetezo cha mankhwalawa komanso kugwiritsa ntchito bwino mapiritsi pagulu la ana, sizikulimbikitsidwa kuti mugwiritse ntchito mankhwalawa kwa ana osakwana zaka 18. Mwanjira yonyansa, kutsegula m'mimba ndi kupweteka pamimba nthawi zambiri kumachitika.
Analogue ndiyotsika mtengo kuchokera ku ma ruble a 1908.
Jardins ndi piritsi yokonzekera odwala matenda ashuga amtundu wa 2. Chofunikira kwambiri pa mankhwalawa ndi empagliflozin. Mankhwala amatengedwa popanda kutafuna musanadye, kapena pakumwa chakudya, ngati mankhwalawa adaphonya - palibe chifukwa choti muwonjezere mlingo wotsatira. Sizikudziwika kuti mankhwalawa amakhudza bwanji pakati komanso sayenera kumwa panthawi yoyamwitsa.
Diagninide (mapiritsi) Kukala: 85 Pamwamba
Analogue ndiyotsika mtengo kuchokera ku ma ruble a 1908.
Diagninide ndi mankhwala opanga hypoglycemic, omwe amaphatikizanso repaglinide. Ngati zakudya zama carb ochepa komanso maphunziro akuthupi sizithandiza kuti shuga azikhala bwino, ndiye kuti mungomwa mankhwalawo. Kwa oyendetsa magalimoto ndi anthu omwe ali ndi ntchito yomwe imafuna chidwi chochulukirapo - mwachidwi chachikulu muyenera kutenga diagnostid. Ngati odwala asokoneza ntchito ya chiwindi kapena impso, mankhwalawa amatengedwa mosamala kwambiri.
Invokana (mapiritsi) Kukala: 99 Pamwamba
Analogue ndiokwera mtengo kwambiri kuchokera ku ma ruble 311.
Attokana - mapiritsi, ofanana ndi makapisozi mu chipolopolo, olembedwa ndi CFZ. Kanagliflozin ndi mankhwala omwe amagwiritsidwa ntchito pa mankhwalawa. Invokana ndi wa mtundu watsopano wa othandizira a hypoglycemic ndipo amapereka chithandizo chabwino kwa odwala matenda ashuga. Mankhwalawa amapatsidwa mankhwala ochizira odwala matenda a shuga a mtundu wachiwiri.
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Zakudya za anthu odwala matenda ashuga: maphikidwe
Maphikidwe a odwala matenda ashuga ochokera ku Alexander Seleznev - wopanda ufa ndi shuga. Zikuwoneka kuti zakudya za anthu odwala matenda ashuga sizitanthauza zakudya zabwino komanso zosakhwima. ... -
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