Mapiritsi a Augmentin 125: malangizo ogwiritsira ntchito

Mapiritsi Ovomerezeka, 500 mg / 125 mg ndi 875 mg / 125 mg

Piritsi limodzi lili

ntchito: amoxicillin (monga amoxicillin trihydrate 500 mg kapena 875 mg,

clavulanic acid (monga potaziyamu clavulanate) 125 mg,

zokopa: magnesium stearate, sodium wowuma glycolate mtundu A, silicon dioxide colloidal anhydrous, microcrystalline cellulose,

kapangidwe kazinthu: titanium dioksidi (E 171), hypromellose (5 cps), hypromellose (15 cps), macrogol 4000, macrogol 6000, mafuta a silicone (dimethicone 500).

500 mg / 125 mg mapiritsi

Mapiritsi okhala ndi zokutira ndiwotayidwa kuyambira oyera mpaka oyera pamtundu, olembedwa "A C" ndi notch mbali imodzi komanso yosalala mbali inayo.

Mapiritsi 875 mg / 125 mg

Mapiritsi okhala ndi mbali ndiwowoneka bwino kuyambira oyera mpaka oyera, ali ndi notolo mbali imodzi ndi "A C" wolemba mbali zonse ziwiri za phale.

Mankhwala

Farmakokinetics

Amoxicillin ndi clavulanate amasungunuka bwino pamankhwala amadzimadzi ndi pH yachilengedwe, zinthu zonsezi zimagwira mwachangu komanso zimatha kutuluka m'mimba kuchokera pakamwa. Mafuta a amoxicillin ndi clavulanic acid ndi bwino akamwa mankhwalawa koyambirira kwa chakudya. Mutatha kumwa mankhwalawo mkati, kuphatikiza kwake ndi 70%. Mbiri ya zigawo zonse ziwiri za mankhwalawa ndi ofanana ndipo imafika pachimake cha plasma (Tmax) pafupifupi ola limodzi. Magetsi a amoxicillin ndi clavulanic acid mu seramu yamagazi ndi ofanana onse pakakhala ntchito ya amoxicillin ndi clavulanic acid, ndipo gawo lililonse limasiyanitsidwa.

Kumangiriza kwa amoxicillin ndi clavulanic acid kuma protein a plasma ndizochepa: 25% ya clavulanic acid ndi 18% ya amoxicillin. Kuchulukitsa komwe kumawoneka ndi pafupifupi 0.3-0.4 l / kg kwa amoxicillin ndi pafupifupi 0,2 l / kg ya clavulanic acid.

Pambuyo pa utsogoleri wa iv, njira zochizira za amoxicillin ndi clavulanic acid zimatheka ndi ziwalo zosiyanasiyana komanso minyewa, kuchuluka kwamkati (mapapu, ziwalo zam'mimba, chikhodzodzo) sputum). Amoxicillin ndi clavulanic acid mothandizidwa samalowa mu madzi a cerebrospinal.

Amoxicillin, monga ma penicillin ambiri, amathandizidwa mkaka wa m'mawere. Zotsatira za clavulanic acid zapezekanso mkaka wa m'mawere. Kupatula kupezeka kwa chiwopsezo cha kukhudzidwa, amoxicillin ndi clavulanic acid sizimawononga thanzi la ana akhanda omwe akuyamwa. Amoxicillin ndi clavulanic acid amawoloka placental zotchinga.

Amoxicillin amapukusidwa pang'ono mu mkodzo wofanana ndi penicillinic acid wofanana ndi 10-25% ya mankhwalawa. Clavulanic acid m'thupi imakhala ndi kagayidwe kakakulu ndipo amatsitsidwa mu mkodzo ndi ndowe, komanso mpweya wa mpweya m'mlengalenga.

Amoxicillin amachotseredwa makamaka ndi impso, pomwe clavulanic acid imachotsedwanso ndi machitidwe a impso ndi owonjezera. Pambuyo pakamwa limodzi lokha piritsi limodzi la 250 mg / 125 mg kapena 500 mg / 125 mg, pafupifupi 60-70% ya amoxicillin ndi 40-65% ya clavulanic acid amachotsedwa mu mkodzo m'maola 6 oyamba.

Kafukufuku wambiri watsimikizira kuti kwamikodzo am'mimba ndi 50-85% ya amoxicillin ndi 27-60% ya clavulanic acid mkati mwa maola 24. Kwa clavulanic acid, kuchuluka kwakukulu kumachotsedwa m'maola awiri atangoyambika.

Kugwiritsidwa ntchito kwa pompenecid kumachepetsa kupweteka kwa impso, koma sikuchedwetsa kuchulukana kwa clavulanic acid ndi impso.

Mankhwala

Augmentin® ndi mankhwala ophatikiza okhala ndi amoxicillin ndi clavulanic acid, omwe ali ndi zochita zambiri za bactericidal, osagwirizana ndi beta-lactamase.

Amoxicillin Ndi anti-synthetic antiotic (beta-lactam), mawonekedwe owoneka bwino, amagwira ntchito motsutsana ndi michere yambiri yama gramu komanso gram-negative.

The bactericidal limagwirira zake amoxicillin ndi kuletsa biosynthesis wa peptidoglycans wa bakiteriya cell khoma, zomwe zimabweretsa lysis ndi kufa kwa bakiteriya cell.

Amoxicillin atengeka kuti awonongeke ndi beta-lactamase yopangidwa ndi mabakiteriya osagwira, chifukwa chake zochita za amoxicillin zokhazokha sizimaphatikizapo tizilombo tating'onoting'ono timene timapanga michere.

Clavulanic acid - Iyi ndi beta-lactamate, yofanana mu kapangidwe kamakina mpaka ma penicillin, omwe amatha kuphatikiza ma enzymes a beta-lactamase a microsense omwe amalimbana ndi penicillin ndi cephalosporins, potero kupewa kutulutsa kwa amoxicillin. Ma Beta-lactamases amapangidwa ndi mabakiteriya ambiri opanda gramu komanso gram-negative. Clavulanic acid imalepheretsa ma enzymes, kubwezeretsa chidwi cha mabakiteriya ku amoxicillin. Makamaka, imakhala ndi ntchito yayikulu yolimbana ndi plasmid beta-lactamases, yomwe mankhwala osokoneza bongo amakhudzidwa nthawi zambiri, koma osagwira motsutsana ndi mtundu wa 1 chromosomal beta-lactamases.

Kupezeka kwa clavulanic acid ku Augmentin® kumateteza amoxicillin ku zowonongeka za beta-lactamases ndikukulitsa mawonekedwe ake a zochita za antibacterial ndikuphatikizidwa kwa ma cellorganices omwe nthawi zambiri amakhala osagwirizana ndi penicillin ena ndi cephalosporins. Clavulanic acid okhala ngati mankhwala amodzi alibe mphamvu zambiri za antibacterial.

Njira yokana kukana

Pali njira ziwiri zothandizira kukana kwa Augmentin ®:

- inactivation ndi bakiteriya-mabakiteriya, omwe samazindikira zotsatira za clavulanic acid, kuphatikizapo magulu B, C, D

- Kusintha kwa mapuloteni omanga a penicillin, omwe amachititsa kuchepa kwa mgwirizano wa antioxotic pokhudzana ndi microorganism

Kukhazikika kwa khoma la mabakiteriya, komanso njira zopopera, zimatha kuyambitsa kapena kuthandizira kukulitsa kukana, makamaka pamagalamu opanda tizilombo.

Augmentin®ali ndi bactericidal pa zotsatirazi tizilombo:

Zoyipa zamagemu: Bacillius anthracis,Enterococcus faecalis,Gardnerella vaginalis,Listeria monocytogene, Nocardia asteroides,Staphylococcus aureus (tcheru ndi methicillin), coagulase-negative staphylococci (woganizira methicillin), Streptococcus agalactiae,Streptococcus pneumoniae1,Streptococcus pyogene ndi ena beta hemolytic streptococci, gulu Streptococcus viridans,

Ma grram-negative: Chizimbamangochita,Kapnocytophagaspp.,Eikenellacorrodens,Haemophilusfuluwenza,Mwanaxellachibimanga,Neisseriamichere,Pasteurellamultocida

tizilombo toyambitsa matenda: Bacteroides fragilis,Fusobacterium nucleatum,Prevotellaspp.

Ma tizilombo tating'onoting'ono tomwe titha kupezeka nawo

Zoyipa zamagemu: Enterococcusfaecium*

Ma tizilombo okhala ndi chilengedwe:

gram alibeaerobes:Acinetobactermitundu,Choprobacterfreundii,Enterobactermitundu,Legionella pneumophila, Morganella morganii, Providenciamitundu, Pseudomonasmitundu, Serratiamitundu, Stenotrophomonas maltophilia,

china: Chlamydia trachomatis,Chlamydophila pneumoniae, Chlamydophila psittaci, Coxiella burnetti, Mycoplasma pneumoniae.

1 zopatula Streptococcus pneumoniaepenicillin

* Zomverera mwachilengedwe pakakhala zopanda kukana

Zizindikiro zogwiritsidwa ntchito

- pachimake bakiteriya sinusitis (ndi kutsimikizika matenda)

- kutupa kwapakati pakati (pachimake otitis media)

- kuchulukitsa kwa matenda a bronchitis (wokhala ndi chitsimikiziro chotsimikizika)

- matenda a kwamkodzo thirakiti (cystitis, pyelonephritis)

- Matenda a pakhungu ndi minofu yofewa (makamaka, cellulite, kulumidwa ndi nyama, zilonda zapanja ndi phlegmon wa dera la maxillofacial)

- matenda am'mafupa ndi mafupa (makamaka, osteomyelitis)

Malangizo apadera ogwiritsira ntchito antibacterial othandizira ayenera kukumbukiridwa.

Mlingo ndi makonzedwe

Kuzindikira kwa Augmentin ® kumatha kusiyanasiyana ndi malo ndi nthawi. Musanafotokozere mankhwala, ngati kuli kotheka ndikofunikira kuwunika momwe matulukidwewo alili molingana ndi deta yakumaloko ndikuzindikira zamverazo ndikusanthula zitsanzo kuchokera kwa wodwala wina, makamaka ngati akudwala kwambiri.

Augmentin ® ikhoza kugwiritsidwa ntchito pochiza matenda omwe amayamba chifukwa cha michere yovuta kwambiri ya amoxicillin, komanso matenda osakanikirana omwe amayamba chifukwa cha amoxicillin-ndi clavulanate-tinsolini tokhazikika tokhala ndi beta-lactamase.

Mlingo wa mankhwalawa umakhazikitsidwa payokha kutengera zaka, kulemera kwa thupi, impso, matenda othandizira, komanso kuopsa kwa matendawa.

Kuchepetsa chiopsezo chokhudza matenda am'mimba, Augmentin® ikulimbikitsidwa kuti idatenge ndi chakudya kumayambiriro kwa chakudya kuti mayamwidwe kwambiri. Kutalika kwa mankhwalawa kumatengera wodwala momwe amathandizira. Ma pathologies ena (makamaka, osteomyelitis) angafunike nthawi yayitali. Kuchiza sikuyenera kupitilizidwa kwa masiku opitilira 14 popanda kuonanso momwe wodwalayo alili. Ngati ndi kotheka, ntha kuchita njira ya mankhwala (yoyamba, intravenous makonzedwe a mankhwala ndikusinthira kwamkamwa makonzedwe).

Akuluakulu ndi ana opitirira zaka 12 kapena osaposa 40 makilogalamu

Wofatsa kuteteza matenda pang'ono (muyezo)

1 piritsi 500 mg / 125 mg katatu patsiku kapena Piritsi 1 875 mg / 125 mg kawiri pa tsiku

Matenda akulu (otitis media, sinusitis, matenda am'mapapo am'mimba, matenda amkodzo thirakiti)

1-2 mapiritsi 500 mg / 125 mg katatu patsiku kapena Piritsi 1 875 mg / 125 mg 2 kapena katatu pa tsiku

Mlingo wambiri watsiku ndi tsiku kwa akulu ndi ana opitirira zaka 12 omwe amagwiritsa ntchito mapiritsi a 500 mg / 125 mg ndi 1500 mg wa amoxicillin / 375 mg wa clavulanic acid. Mapiritsi okhala ndi mlingo wa 875 mg / 125 mg, muyezo wa tsiku ndi tsiku ndi 1750 mg wa amoxicillin / 250 mg wa clavulanic acid (mukamamwa 2 kawiri patsiku) kapena 2625 mg wa amoxicillin / 375 mg wa clavulanic acid (mukamamwa katatu patsiku).

Ana osakwana zaka 12 kapena masekeli osakwana 40

Fomu ya Mlingoyo siinapangidwe ana osakwana zaka 12 kapena ana osaposa 40 kg. Ana awa amatchulidwa kuti Augmentin ® ngati kuyimitsidwa pakulankhula pakamwa.

Odwala ndi mkhutu aimpso ntchito

Kusintha kwa Mlingo wokhazikitsidwa ndi kuchuluka kwa mlingo woyenera wa amoxicillin ndi kufunika kwa chiwonetsero cha creatinine.

Mlingo wa Augmentin®

Palibe kusintha kwa mlingo kofunikira

1 piritsi 500 mg / 125 mg kawiri pa tsiku

30 ml / mphindi. Odwala a hememalysis

Kusintha kwa Mlingo wokhazikika pazotsatira zoyenera za amoxicillin.

Akuluakulu: 1 piritsi 500 mg / 125 mg maola 24 aliwonse Zosankha Mlingo 1 umayikidwa pa gawo la dialysis ndi gawo lina kumapeto kwa gawo la dialysis (kulipirira kuchepa kwa seramu wozungulira wa amoxicillin ndi clavulanic acid).

Mapiritsi okhala ndi mlingo wa 875 mg / 125 mg ayenera kugwiritsidwa ntchito mwa odwala omwe ali ndi chilolezo cha creatinine> 30 ml / min. Odwala omwe ali ndi vuto la chiwindi

Kuchiza kumachitika mosamala; ntchito ya chiwindi imayang'aniridwa nthawi zonse.

Chepetsani Augmentin Mlingo® sikofunikira, Mlingo ndi wofanana ndi akulu. Okalamba odwala mkhutu aimpso ntchito, mlingo uyenera kusinthidwa monga tafotokozera pamwambapa kwa akulu omwe ali ndi vuto laimpso.

Zotsatira zoyipa

Zotsatira zoyesedwa m'mayesero azachipatala komanso nthawi yotsatsa pambuyo pake amalembedwa pansipa ndipo amalembedwa kutengera kutengera komanso kutengera kwa zinthu zomwe zimachitika mwadzidzidzi.

Pafupipafupi zochitika zimatsimikiziridwa motere: nthawi zambiri (≥1/10), nthawi zambiri (≥1 / 100 ndi

Kutulutsa Fomu

Mankhwalawa ali ndi mitundu yotulutsira iyi:

• Mapiritsi a Augmentin 250 mg + 125 mg, Augmentin 500 mg + 125 mg ndi Augmentin 875 + 125 mg.
• Powder 500/100 mg ndi 1000/200 mg, omwe cholinga chake ndi kukonza njira yothetsera jakisoni.
• Ufa wa kuyimitsidwa kwa Augmentin 400 mg / 57 mg, 200 mg / 28,5 mg, 125 mg / 31.25 mg.
• Powder Augmentin EU 600 mg / 42.9 mg (5 ml) kuyimitsidwa.
• Augmentin CP 1000 mg / 62,5 mg mapiritsi olimbitsa otulutsidwa

Pharmacodynamics ndi pharmacokinetics

Malinga ndi Wikipedia, Amoxicillin ndiye bactericidal wothandizirayogwira polimbana ndi tizilombo tating'onoting'ono tambiri komanso tating'onoting'ono tating'onoting'ono tizilombo ndikuyimira semisynthetic penicillin gulu la mankhwala.

Kupondereza transpeptidase ndikusokoneza njira zopangira mureina (gawo lofunikira kwambiri la makoma a cell ya bakiteriya) panthawi yamagawidwe ndi kukula, zimapangitsa kuti ziwonongeke (chiwonongeko) mabakiteriya.

Amoxicillin wawonongedwa β-lactamaseschifukwa chake ntchito ya antibacterial sikufikira tizilombokupanga β-lactamases.

Kuchita ngati mpikisano ndipo nthawi zambiri ndi cholepheretsa chosasintha, clavulanic acid yodziwika ndi kuthekera kolowera mkati mwa makoma am'nyumba mabakiteriya ndikupangitsa inactivation michereZomwe zili mkati mwa khungu ndi m'malire ake.

Clavulanate mitundu yosakhazikika inasinthidwa ndi β-lactamasesndipo izi zimalepheretsa chiwonongeko amoxicillin.

Mankhwala a Augmentin amagwira ntchito motsutsana:

• Gram (+) aerobes: pyogenic streptococcus magulu A ndi B, pneumococci, Staphylococcus aureus ndi epidermal, (kupatulapo michere yolimbana ndi methicillin), saprophytic staphylococcus ndi ena
• Gram (-) aerobes: Ndodo za Pfeiffer, wambiri chifuwa, gardnerella vaginalis , cholera vibrio etc.
• Gram (+) ndi Gram (-) ya anaerobes: ma bacteria, fusobacteria, preotellasetc.
• Tizilombo tina: chlamydia, spirochete, wotumbululuka treponema etc.

Pambuyo pomeza Augmentin, mbali zake zonse ziwiri zimagwira ntchito mwachangu komanso mwachangu. Mafuta akumwa bwino ngati mapiritsi kapena manyumwa aledzera pakudya (kumayambiriro kwa chakudya).

Onse akumwa pakamwa, komanso poyambitsa yankho la Augmentin IV, njira zochizira zomwe amagwiritsa ntchito zimapezeka mu minyewa yonse komanso madzi amkati.

Magawo onse awiriwa amagwira plasma magazi mapuloteni (mpaka 25% imamangiriza mapuloteni a plasma amoxicillin trihydratendipo osaposa 18% clavulanic acid) Palibe kukondoweza kwa Augmentin komwe kwapezeka m'ziwalo zilizonse zamkati.

Amoxicillin kuvumbulutsidwa kwa kagayidwe mthupi ndipo wachotsedwa impsokudzera m'mimba yogaya komanso momwe mpweya umatulutsira mpweya limodzi ndi mpweya. 10 mpaka 25% ya mlingo womwe walandiridwaamoxicillin kuchotseredwa impso mu mawonekedwe penicilloic acidzomwe sizigwira ntchito metabolite.

Clavulanate chafufutsidwa ndi impso komanso njira zina zowonjezera.

Contraindication

Augmentin mu mitundu yonse ya mulingo wolembedwa:

• odwala hypersensitivity amodzi kapena onse yogwira mankhwala, kwa aliyense wa iwo β-lactam (i.e. to maantibayotiki ochokera m'magulu penicillin ndi cephalosporin),
• odwala omwe akumana ndi machitidwe a Augmentin chithandizo jaundice kapena mbiri yachitetezo cha ntchito chiwindi chifukwa chogwiritsa ntchito kuphatikiza pazinthu zomwe zimagwiritsidwa ntchito ndi mankhwala.

Kutsutsana kwapadera pakukhazikitsidwa kwa ufa pokonzekera kuyimitsidwa pakamwa ndi Mlingo wa zinthu zofunikira za 125 + 31.25 mg ndi PKU (phenylketonuria).

Ufa womwe umagwiritsidwa ntchito pokonzekera kuyimitsidwa kwa pakamwa ndi Mlingo wa zinthu zofunikira (200 + 28,5) ndi (400 + 57) mg ndi zotsutsana:

• at PKU,
• odwala osokonezeka impsokomwe zizindikiroMayeso a Reberg pansipa 30 ml pa mphindi
• ana osakwana miyezi itatu.

Zowonjezera zina zotsutsana ndikugwiritsa ntchito mapiritsi okhala ndi Mlingo wa zinthu zomwe zimagwira (250 + 125) ndi (500 + 125) mg ali ndi zaka 12 kapena / kapena zolemera zosakwana 40 kilogalamu.

Mapiritsi okhala ndi Mlingo wa yogwira zinthu 875 + 125 mg ndiwotsutsana:

• kuphwanya ntchito yogwira ntchito impso (Zizindikiro Mayeso a Reberg pansipa 30 ml pa mphindi)
• ana ochepera zaka 12
• odwala omwe kulemera kwawo kwa thupi sikupitirira 40 kg.

Ntchito malangizo Augmentin: njira ntchito, Mlingo wa odwala ndi ana akuluakulu

Chimodzi mwazomwe zimafunsidwa kwambiri ndi wodwala ndikufunsa momwe mungamwe mankhwalawa musanadye kapena mutatha kudya. Pankhani ya Augmentin, kumwa mankhwalawa kumagwirizana kwambiri ndi kudya. Amamuwona ngati woyenera kumwa mankhwalawo mwachindunji. asanadye.

Choyamba, zimapereka kuyamwa bwino kwa zinthu zomwe zimagwira Matumbo, ndipo, chachiwiri, zimachepetsa kwambiri kuvuta dyspeptic matenda am'mimba thirakitingati izi zili choncho.

Momwe mungawerengere mlingo wa Augmentin

Momwe mungamwe mankhwalawa Augmentin kwa akulu ndi ana, komanso muyezo wochizira, kutengera zomwe tizilombo Ndi tizilombo toyambitsa matenda, timakhudzidwa motani ndi kukhudzana mankhwala, zovuta ndi machitidwe a matendawa, kudziwa kwawonekera kwa matenda opatsirana, zaka komanso kulemera kwa wodwala, komanso momwe alili wathanzi impso wodwala.

Kutalika kwa maphunzirowa kumatengera momwe thupi la wodwalayo limayankhira chithandizo.

Mapiritsi a Augmentin: malangizo ogwiritsira ntchito

Kutengera ndi zomwe zili ndi zomwe zili mmenemo, mapiritsi a Augmentin akulimbikitsidwa kuti odwala akuluakulu atenge malinga ndi dongosolo lotsatira:

• Augmentin 375 mg (250 mg + 125 mg) - kamodzi katatu patsiku. Mlingo wotere, mankhwalawa akuwonetsedwa matendaomwe amayenda zosavuta kapena mawonekedwe owopsa. Muzochitika za matenda akulu, kuphatikiza masiku ndi apo, Mlingo wapamwamba ndi mankhwala.
• Mapiritsi a 625 mg (500 mg + 125 mg) - kamodzi katatu patsiku.
• Mapiritsi a 1000 mg (875 mg + 125 mg) - kamodzi kawiri pa tsiku.

Mlingo umayenera kuwongoleredwa kwa odwala omwe ali ndi vuto la ntchito. impso.

Augmentin SR 1000 mg / 62,5 mg mapiritsi otulutsidwa otulutsidwa amangololeza kwa odwala azaka zopitilira 16. Mulingo woyenera ndi mapiritsi awiri kawiri patsiku.

Ngati wodwala sangameze piritsi lonse, lagawika pawiri molakwika. Ma halves onse awiri amatengedwa nthawi yomweyo.

Odwala odwala impso The mankhwala zotchulidwa pokhapokha ngati chizindikiro Mayeso a Reberg amapitilira 30 ml pa mphindi (ndiye kuti, ngati zosintha muyezo safunika).

Ufa wa yankho la jakisoni: malangizo ogwiritsira ntchito

Malinga ndi malangizo, yankho la jekeseni limalowa m'mitsempha: ndi jet (mlingo wonse uyenera kuperekedwa pakadutsa mphindi 3-4) kapena ndi njira ya kukapanda kuleka (kuchokera pakadutsa ola limodzi mpaka mphindi 40). Njira yothetsera vutoli sikuti idalowetsedwa m'matumbo.

Mlingo wokhazikika kwa wodwala wamkulu ndi 1000 mg / 200 mg. Ndikulimbikitsidwa kuti muzilowa maola asanu ndi atatu aliwonse, komanso kwa iwo omwe ali ndi zovuta matenda - aliyense maola asanu ndi limodzi kapena anayi (malingana ndi mawonekedwe).

Antibiotic mwanjira yothetsera yankho, 500 mg / 100 mg kapena 1000 mg / 200 mg ndi mankhwala wotseka chitukuko matenda pambuyo opaleshoni. Nthawi yomwe opaleshoniyo imakhala yochepera ola limodzi, ndikokwanira kulowa wodwala kamodzi opaleshoni Mlingo wa Augmentin 1000 mg / 200 mg.

Ngati mukuganiza kuti opaleshoniyo imatha kupitirira ola limodzi, mpaka madontho anayi a 1000 mg / 200 mg amaperekedwa kwa wodwala tsiku latha la maola 24.

Kuyimitsidwa kwa Augmentin: malangizo ogwiritsira ntchito

Malangizo ogwiritsira ntchito Augmentin kwa ana amalimbikitsa kuperekedwa kwa kuyimitsidwa kwa 125 mg / 31.25 mg muyezo wa 2,5 mpaka 20 ml. Kuchulukana kwa phwando - 3 masana. Kuchuluka kwa mlingo umodzi kumatengera zaka ndi kulemera kwa mwana.

Ngati mwana ndi wamkulu kuposa miyezi iwiri, kuyimitsidwa kwa 200 mg / 28,5 mg amamulembera muyezo wofanana ndi 25 / 3,6 mg mpaka 45 / 6.4 mg pa 1 kg ya thupi. Mlingo womwe wafotokozedwayo uyenera kugawidwa pawiri.

Kuyimitsidwa ndi Mlingo wa yogwira zinthu 400 mg / 57 mg (Augmentin 2) akuwonetsedwa kuti azigwiritsidwa ntchito kuyambira chaka. Kutengera zaka komanso kulemera kwa mwana, mlingo umodzi umasiyana kuchokera pa 5 mpaka 10 ml. Kuchulukana kwa phwando - 2 masana.

Augmentin EU amalembedwa kuyambira miyezi itatu. Mulingo woyenera ndi 90 / 6.4 mg pa 1 kg ya kulemera kwa thupi patsiku (mlingo uyenera kugawidwa mu 2 Mlingo, kusunga maola 12 pakati pawo).

Masiku ano, mankhwalawa amapezeka mu mitundu yambiri ya mankhwala. zilonda zapakhosi.

Ana Augmentin ndi zilonda zapakhosi zotchulidwa muyezo kuti amadzipereka zochokera thupi ndi zaka za mwana. Ndi angina akuluakulu, tikulimbikitsidwa kugwiritsa ntchito Augmentin pa 875 + 125 mg katatu patsiku.

Komanso, nthawi zambiri amatengera kuikidwa kwa Augmentin sinusitis. Mankhwalawa amathandizidwa ndikutsuka mphuno ndi mchere wamchere ndikugwiritsira ntchito mitsuko yamkati yamtunduwo Rinofluimucil. Mlingo woyenera wa sinusitis: 875/125 mg 2 kawiri pa tsiku. Kutalika kwa maphunzirowa nthawi zambiri kumakhala masiku 7.

Bongo

Kuchulukitsa mlingo wa Augmentin limodzi ndi:

• chitukuko cha kuphwanya kugaya chakudya,
• kuphwanya mulingo wamchere wamadzi,
• khalid,
• kulephera kwa aimpso,
• mpweya (mpweya) wa amoxicillin mu catheter wa kwamikodzo.

Zizindikiro zotere zikawoneka, wodwalayo amawonetsedwa monga chithandizo cha mankhwala, kuphatikiza pazinthu zina, kukonza kwa mchere wamchere wamchere. Kuchotsedwa kwa Augmentin ku kutidongosolo lofanana imathandizanso njirayi hemodialysis.

Kuchita

• amathandizira kuchepetsa katulutsidwe katulutsidwe amo amoillillin,
• kumapangitsa kuchuluka kwa ndende amoxicillin mu magazi a m'magazi (zotsatira zake zikupitilira kwanthawi yayitali),
• sizikhudza malo ndi kuchuluka kwa zomwe zili plasma wa clavulanic acid.

Kuphatikiza amoxicillin ndi allopurinol kumawonjezera mwayi kukulitsa mawonekedwe chifuwa. Chiyanjano Pakati allopurinol nthawi yomweyo ndi magawo awiri azigawo a Augmentan palibe.

Augmentin ali ndi tanthauzo pa zomwe zili matumbo thirakiti microflorazomwe zimadzetsa kuchepa kwa kubwezeretsanso (kupatutsa kuyamwa) estrogen, komanso kuchepa kwa magwiridwe antchito ophatikizika njira zakulera pakamwa.

Mankhwalawa sagwirizana ndi zinthu zamagazi ndi zinthu zama protein, kuphatikizapo kuphatikiza Whey protein hydrolysates ndi emulsions yamafuta omwe cholinga chake ndi kulowetsedwa mu mtsempha.

Ngati Augmentin adayikidwa pamodzi maantibayotiki kalasi aminoglycosides, mankhwalawa sanaphatikizidwe mu syringe imodzi kapena chidebe chilichonse musanayende, chifukwa izi zimapangitsa kuti inactivation aminoglycosides.

Ma Analogs a Augmentin

Ma analog a Augmentin ndi mankhwala osokoneza bongoA-Klav-Farmeks, Amoxiclav, Amoxil-KBetaclava Clavamitin, Samalirani, Teraclav.

Iliyonse mwamankhwala omwe ali pamwambapa ndi omwe Augmentin amatha kusinthidwa posakhalapo.

Mtengo wa analogues umasiyana kuchokera pa 63.65 mpaka 333.97 UAH.

Augmentin wa ana

Augmentin amagwiritsidwa ntchito kwambiri machitidwe a ana. Chifukwa chakuti ili ndi mawonekedwe a ana omasulidwa - madzi, amatha kugwiritsidwa ntchito pochiritsa ana mpaka chaka. Momwe amathandizira kulandira komanso momwe mankhwalawo amakomekera.

Kwa ana mankhwalanthawi zambiri zotchulidwa zilonda zapakhosi. Mlingo wa kuyimitsidwa kwa ana umatsimikiziridwa ndi msinkhu komanso kulemera. Mulingo woyenera kwambiri umagawidwa Mlingo wachiwiri, wofanana ndi 45 mg / kg patsiku, kapena wogawika patatu, waukulu 40 mg / kg patsiku.

Momwe mungamwe mankhwalawa kwa ana ndi kuchuluka kwa Mlingo zimatengera mtundu wa mankhwala.

Kwa ana omwe thupi lawo limaposa 40 makilogalamu, Augmentin amatchulidwa muyezo womwewo ndi odwala akulu.

Mankhwala a Augmentin a ana mpaka chaka amagwiritsidwa ntchito Mlingo wa 125 mg / 31.25 mg ndi 200 mg / 28,5 mg. Mlingo wa 400 mg / 57 mg amawonetsedwa kwa ana osaposa chaka chimodzi.

Ana omwe ali ndi zaka 6-12 (zolemera kuposa makilogalamu 19) amaloledwa kupereka kuyimitsidwa komanso Augmentin pamapiritsi. Mlingo wa mankhwala a piritsi ndi motere:

• piritsi limodzi 250 mg + 125 mg katatu patsiku,
• piritsi limodzi 500 + 125 mg kawiri patsiku (fomu iyi ya mulingo woyenera).

Ana osaposa zaka 12 amafunsidwa kumwa piritsi limodzi la 875 mg + 125 mg kawiri pa tsiku.

Kuti muyezo moyenera muyezo wa kuyimitsidwa kwa Augmentin kwa ana osaposa miyezi 3, tikulimbikitsidwa kuti mulembe madzi ndi syringe yokhala ndi chisonyezo. Kuthandizira kugwiritsidwa ntchito kwa kuyimitsidwa kwa ana osaposa zaka ziwiri, amaloledwa kuthira madzi ndi madzi muyezo wa 50/50

Ma analogu a Augmentin, omwe ali m'malo ake a pharmacological, ndi mankhwala osokoneza bongo Amoxiclav, Flemoklav Solutab, Arlet, Rapiclav, Mochulukitsa.

Kuyenderana ndi mowa

Augmentin ndi mowa ndiye kuti sikuti amatsutsana ndi mowa wa ethyl mankhwalasasintha momwe amagulitsira mankhwala.

Ngati motsutsana ndi maziko a mankhwala osokoneza bongo mukufunika kumwa mowa, ndikofunikira kutsatira ziwiri izi: kusanja komanso kuthamanga.

Kwa anthu omwe akudwala mowa, kugwiritsa ntchito mankhwalawa pamodzi ndi mowa kumatha kukhala ndi zotsatirapo zowopsa.

Kuledzeretsa mwadongosolo kumadzetsa zisokonezo zosiyanasiyana pantchito chiwindi. Odwala odwala chiwindi Malangizowo akuwonetsa kuti Augmentin akhazikitsidwe mosamala kwambiri, chifukwa zimanenedweratu momwe chiwalo chodwala chizitha kuyesereraxenobioticzovuta kwambiri.

Chifukwa chake, popewa chiopsezo chosavomerezeka, tikulimbikitsidwa kuti musamwe mowa nthawi yonse ya mankhwalawa.

Augmentin pa nthawi yoyembekezera

Monga maantibayotiki ambiri gulu la penicillin, amoxicillin, yogawidwa m'thupi lathu, imalowanso mkaka wa m'mawere. Kuphatikiza apo, zofufuza zimatha kupezeka mkaka. clavulanic acid.

Komabe, palibe vuto lililonse pakubadwa kwa mwana lomwe limadziwika. Nthawi zina, kuphatikiza clavulanic acid ndi amoxicillin zimatha kuyambitsa khanda kutsegula m'mimba ndi / kapena candidiasis (thrush) wa mucous nembanemba mkamwa.

Augmentin ali m'gulu la mankhwala omwe amaloledwa kuyamwitsa. Komabe, poyerekeza ndi momwe mayiyo amathandizira ndi Augmentin, mwana amakhala ndi zovuta zina, kuyamwitsa kuyimitsidwa.

Kafukufuku wazinyama awonetsa kuti zinthu zothandiza za Augmentin zimatha kulowa hematoplacental (GPB) chotchinga. Komabe, palibe zoyipa pakukula kwa fetal zomwe zapezeka.

Komanso, mphamvu za teratogenic sizinapezeke pakukonzekera mankhwala ndi pakamwa komanso pakamwa.

Kugwiritsa ntchito Augmentin mwa amayi apakati kungayambitse khanda lobadwa kumene necrotizing enterocolitis (NEC).

Monga mankhwala ena onse, Augmentin sakuvomerezeka kwa amayi apakati. Panthawi yoyembekezera, kugwiritsa ntchito kovomerezeka kumakhala kovomerezeka pokhapokha ngati malinga ndi mayeso a dokotala, phindu la mkazi limaposa ngozi zomwe zingakhalepo kwa mwana wake.

Ndemanga za Augmentin

Ndemanga ya mapiritsi ndi kuyimitsidwa kwa ana Augmentin gawo lalikulu zabwino. Ambiri amaganiza kuti mankhwalawa ndi mankhwala othandiza komanso odalirika.

Pamabwalo omwe anthu amagawana zomwe akumwa mankhwala ena, mankhwala ochepetsa mphamvu ya kachilombo ka HIV ndi 4,3,5,5 mwa mfundo zisanu.

Ndemanga za Augmentin osiyidwa ndi amayi a ana aang'ono zikuwonetsa kuti chida chimathandizira kuthana ndimatenda a ana monga bronchitis kapena zilonda zapakhosi. Kuphatikiza pa kugwiritsa ntchito mankhwalawa, amayi amawonanso kukoma kwake kosangalatsa, komwe ana amakonda.

Chidachi chimagwiranso ntchito pa nthawi ya pakati. Ngakhale kuti malangizowo samalimbikitsa kupereka chithandizo kwa amayi apakati (makamaka mu trimester ya 1), Augmentin nthawi zambiri amatchulidwa mu 2nd ndi 3 trimesters.

Malinga ndi madotolo, chinthu chachikulu mukamachiritsa ndi chida ichi ndikuwona kuchuluka kwa mankhwalawo ndikutsatira malingaliro onse a dokotala.

Mtengo wa Augmentin

Mtengo wa Augmentin ku Ukraine umasiyana malinga ndi mankhwala enaake. Nthawi yomweyo, mtengo wa mankhwalawo ndiwokwera pang'ono m'mafakitala ku Kiev, mapiritsi ndi manyumwa m'misika ku Donetsk, Odessa kapena Kharkov amagulitsidwa pamtengo wotsika pang'ono.

Mapiritsi a 625 mg (500 mg / 125 mg) amagulitsidwa ku malo ogulitsa mankhwala, pafupifupi, pa 83-85 UAH. Mtengo wapakati wa mapiritsi a Augmentin 875 mg / 125 mg - 125-135 UAH.

Mutha kugula maantibayotiki mu ufa wa ufa pokonzekera njira yothetsera jakisoni ndi mulingo wa 500 mg / 100 mg wa zinthu zogwiritsidwa ntchito, pafupifupi, chifukwa cha 218-225 UAH, mtengo wamba wa Augmentin 1000 mg / 200 mg - 330-354 UAH.

Mtengo wa kuyimitsidwa kwa Augmentin kwa ana:
400 mg / 57 mg (Augmentin 2) - 65 UAH,
200 mg / 28,5 mg - 59 UAH,
600 mg / 42.9 mg - 86 UAH.

Njira yamachitidwe

Amoxicillin ndi mankhwala osokoneza bongo owoneka bwino ochulukirapo omwe ali ndi ntchito yolimbana ndi ma gram ambiri komanso gram alibe tizilombo. Nthawi yomweyo, amoxicillin imayamba kuwonongeka ndi beta-lactamases, chifukwa chake ntchito yokhala ndi amoxicillin sinafikira ku tizilombo tating'onoting'ono tomwe timatulutsa timadzi tambiri.

Clavulanic acid, beta-lactamase inhibitor yokhudzana ndi penicillin, amatha kuyambitsa mitundu yambiri ya beta-lactamases yomwe imapezeka mu penicillin ndi cephalosporin zosagwira tizilombo. Clavulanic acid ili ndi mphamvu yokwanira yolimbana ndi plasmid beta-lactamases, yomwe nthawi zambiri imatsimikiza kukana kwa mabakiteriya, ndipo sagwira ntchito motsutsana ndi mtundu wa 1 wa chromosomal beta-lactamases, womwe suletsedwa ndi clavulanic acid.

Kukhalapo kwa clavulanic acid mu kukonzekera kwa Augmentin kumateteza amoxicillin kuti asawonongedwe ndi ma enzyme - beta-lactamases, omwe amalola kukulitsa mawonekedwe a antibacterial a amoxicillin.

Kugawa

Monga kuphatikizira kwa mtsempha wa amoxicillin ndi clavulanic acid, njira zochizira za amoxicillin ndi clavulanic acid zimapezeka m'misempha yambiri komanso mkati mwazigawo (mu ndulu, matumbo am'mimba, khungu, adipose ndi minofu minofu, zotumphukira ndi zotumphukira). .

Amoxicillin ndi clavulanic acid ali ndi malire ofooka a mapuloteni a plasma. Kafukufuku wasonyeza kuti pafupifupi 25% ya kuchuluka kwathunthu kwa clavulanic acid ndi 18% ya amoxicillin m'magazi am'magazi amaphatikizika ndi mapuloteni amadzi a m'madzi.

Mu maphunziro a nyama, palibe chowerengera cha zigawo za kukonzekera kwa Augmentin® mu chiwalo chilichonse chomwe chidapezeka. Amoxicillin, monga ma penicillin ambiri, amadutsa mkaka wa m'mawere. Zotsatira za clavulanic acid zimapezekanso mkaka wa m'mawere. Kupatula kuthekera kwa kutulutsa chidwi, kutsegula m'mimba, kapena candidiasis ya mucous membrane wamkamwa, palibe zovuta zina za amoxicillin ndi clavulanic acid pa thanzi la makanda oyamwa

Kafukufuku wothandizira kubereka kwanyama akuwonetsa kuti amoxicillin ndi clavulanic acid amawoloka chotchinga. Komabe, palibe zoyipa zilizonse pa mwana wakhanda zomwe zapezeka.

Kupenda

10-25% ya mlingo woyambirira wa amoxicillin amuchotseredwa ndi impso ngati yogwira metabolite (penicilloic acid). Clavulanic acid imapangidwa modabwitsa kwambiri mpaka 2,5-dihydro-4- (2-hydroxyethyl) -5-oxo-1 H-pyrrole-3-carboxylic acid ndi 1-amino-4-hydroxybutan-2-imodzi ndikufotokozedwa ndi impso. kudzera m'mimba, komanso ndi mpweya wotha ntchito mu mpweya wa kaboni.

Monga ma penicillin ena, amoxicillin amathandizidwa ndi impso, pomwe clavulanic acid imachotsedwanso ndi machitidwe a impso komanso owonjezera.

Pafupifupi 60-70% ya amoxicillin ndi 40-65% ya clavulanic acid amachotsedwa ndi impso zosasinthika maola 6 oyambilira atatha kupatsidwa mankhwala. Makonzedwe omwewo a probenecid amachedwetsa kuphipha kwa amoxicillin, koma osati clavulanic acid.

Mlingo ndi makonzedwe

Zokhudza pakamwa.

Mlingo wa mankhwalawa umayikidwa payekha kutengera zaka, kulemera kwa thupi, impso ya wodwalayo, komanso kuopsa kwa matendawa. Kuti muchepetse kusokonezeka kwa m'mimba ndikuwonjezera kuyamwa, mankhwalawa ayenera kumwedwa kumayambiriro kwa chakudya. Njira yochepetsetsa ya mankhwala opha maantibayotiki ndi masiku 5.

Kuchiza sikuyenera kupitilira masiku opitilira 14 osanenapo za matenda.

Ngati ndi kotheka, ndikotheka kuchitapo kanthu pang'onopang'ono (oyamba, makonzedwe a Augmentin ® mu mawonekedwe a mlingo; ufa pokonzekera njira yothandizira pakukonzekera kwamkati ndi kusintha kwina kwa kukonzekera kwa Augmentin ® mitundu yamafomu).

Kumbukirani kuti mapiritsi awiri a Augmentin® 250 mg + 125 mg siofanana ndi piritsi limodzi la Augmentin® 500 mg + 125 mg.

Odwala a hememalysis

Kusintha kwa mankhwalawa kutengera mlingo waukulu wa amoxicillin. 1 piritsi 500 mg + 125 mg mu gawo limodzi maola 24 aliwonse

Pa gawo la dialysis, gawo limodzi la piritsi 1 (piritsi limodzi) ndi piritsi lina kumapeto kwa gawo la dialysis (kulipirira kuchepa kwa kuchuluka kwa seramu ya amoxicillin ndi clavulanic acid).

Mimba

Mu maphunziro a kubereka mu nyama, pakamwa komanso mwa uchembere wa Augmentin ® sizinayambitse zotsatira za teratogenic. Pa kafukufuku m'modzi mwa azimayi omwe ali ndi matuza kusanachitike, anapezeka kuti mankhwala a prophylactic amatha kuphatikizidwa ndi chiopsezo chowonjezeka cha necrotizing enterocolitis akhanda. Monga mankhwala onse, Augmentin® siyikulimbikitsidwa kuti mugwiritse ntchito panthawi yomwe muli ndi pakati, pokhapokha ngati phindu lomwe mayi akuyembekezera limaposa chiwopsezo cha mwana wosabadwayo.

Nthawi yoyamwitsa

Mankhwala Augmentin® angagwiritsidwe ntchito poyamwitsa. Kupatula kuti kuthekera kwa kutulutsa chidwi, kutsegula m'mimba, kapena masoka a mucous nembanemba amkati omwe amalumikizana ndi kulowetsedwa kwa kuchuluka kwa zinthu zomwe zimagwira popanga mankhwalawa mkaka wa m'mawere, palibe zovuta zina zomwe zimawonedwa mwa makanda oyamwa. Pakakhala zovuta m'makanda oyamwitsa, kuyamwitsa kuyenera kusiyidwa.

Malangizo apadera

Asanayambe kugwiritsa ntchito Augmentin, wodwala wodwalayo ayenera kudziwa zomwe zimachitika mu penicillin, cephalosporin ndi zina.

Kuyimitsidwa kwa Augmentin kumatha kusokoneza mano a wodwalayo. Popewa kukula kwa zoterezi, ndikokwanira kutsatira malamulo oyambira aukhondo - kupukuta mano, kugwiritsa ntchito misempha.

Kuvomerezedwa Augmentin kungayambitse chizungulire, kotero, pakakhala nthawi yayitali, sayenera kuyendetsa magalimoto ndikuchita ntchito yomwe imafuna chidwi chachikulu.

Augmentin sangagwiritsidwe ntchito ngati mtundu wopatsirana wa mononucleosis ukayikiridwa.

Augmentin amakhala wololera bwino komanso wowopsa. Ngati mankhwalawa agwiritsidwa ntchito kwa nthawi yayitali, ndiye kuti nthawi zina amafunika kuyang'ana impso ndi chiwindi.

Gulu la Nosological (ICD-10)

1 Popanga mankhwalawa, potaziyamu clavulanate amagona ndi 5% yowonjezera.

1 Madzi oyeretsedwa amachotsedwa nthawi yovala filimu.

Kufotokozera za mtundu wa kipimo

Mphamvu: yoyera kapena pafupifupi yoyera, yokhala ndi fungo labwino. Ikaphatikizidwa, kuyimitsidwa koyera kapena pafupifupi koyera kumapangidwa. Poimirira, yoyera kapena yoyera imayamba pang'onopang'ono.

Mapiritsi, 250 mg + 125 mg: yokutidwa ndi nembanemba wa filimu kuyambira yoyera mpaka pafupi yoyera, yopanda mawonekedwe, yolembedwa "AUGMENTIN" mbali imodzi. Pa kink: kuchokera pamaso achikasu mpaka oyera.

Mapiritsi, 500 mg + 125 mg: yokutidwa ndi chithunzi cha filimu kuyambira yoyera mpaka pafupifupi yoyera, chowongolera, cholembedwa "AC" ndikuyika pachiwopsezo mbali imodzi.

Mapiritsi, 875 mg + 125 mg: wokutidwa ndi filimu yolimba kuyambira yoyera mpaka yoyera, yoloweka mawonekedwe, yokhala ndi zilembo "A" ndi "C" mbali zonse ziwiri ndi mzere wolakwika mbali imodzi. Pa kink: kuchokera pamaso achikasu mpaka oyera.

Pharmacokinetics

Zosakaniza zonse ziwiri za kukonzekera kwa Augmentin ® - amoxicillin ndi clavulanic acid - zimatengedwa mwachangu komanso mokwanira kuchokera m'mimba kuchokera pakamwa. Kuyamwa kwa yogwira pophika mankhwala a Augmentin ® ndi mulingo woyenera ngati mankhwalawa atengedwa kumayambiriro kwa chakudya.

Ma paracokinetic magawo a amoxicillin ndi clavulanic acid omwe amapezeka mu maphunziro osiyanasiyana akuwonetsedwa pansipa, pamene odzipereka athanzi omwe ali ndi zaka 2 mpaka 12 pamimba yopanda kanthu amatenga 40 mg + 10 mg / kg / tsiku la mankhwalawa Augmentin ® pamiyeso itatu, ufa woyimitsidwa pakamwa. 125 mg + 31.25 mg mu 5 ml (156.25 mg).

Magawo a pharmacokinetic oyambira

Amoxicillin

Augmentin ®, 125 mg + 31.25 mg mu 5 ml

Clavulanic acid

Augmentin ®, 125 mg + 31.25 mg mu 5 ml

Ma paracokinetic magawo a amoxicillin ndi clavulanic acid omwe amapezeka mu maphunziro osiyanasiyana akuwonetsedwa pansipa, pomwe odzipereka athanzi omwe ali ndi zaka 2 mpaka 12 pamimba yopanda kanthu amatenga Augmentin ®, ufa kuti ayimitsidwe pakamwa, 200 mg + 28,5 mg mu 5 ml (228 , 5 mg) pa mlingo wa 45 mg + 6,4 mg / kg / tsiku, logawidwa pawiri.

Magawo a pharmacokinetic oyambira

Ma paracokinetic magawo a amoxicillin ndi clavulanic acid omwe amapezeka mu maphunziro osiyanasiyana akuwonetsedwa pansipa, pamene odzipereka athanzi atatenga mlingo umodzi wa Augmentin ®, ufa kuti ayimitse pakamwa, 400 mg + 57 mg mu 5 ml (457 mg).

Magawo a pharmacokinetic oyambira

Ma paracokinetic magawo a amoxicillin ndi clavulanic acid, omwe amapezeka m'maphunziro osiyanasiyana, pomwe odzipereka othamanga athanzi adatenga:

- 1 tabu. Augmentin ®, 250 mg + 125 mg (375 mg),

- Mapiritsi 2 Augmentin ®, 250 mg + 125 mg (375 mg),

- 1 tabu. Augmentin ®, 500 mg + 125 mg (625 mg),

- 500 mg wa amoxicillin,

- 125 mg ya clavulanic acid.

Magawo a pharmacokinetic oyambira

Amoxicillin mu kapangidwe ka mankhwala Augmentin ®

Clavulanic acid mu kapangidwe ka mankhwala Augmentin ®

Mukamagwiritsa ntchito mankhwala a Augmentin ®, kuchuluka kwa plasma kwa amoxicillin ndi ofanana ndi omwe ali ndi kamwa yokhala ndi milingo yofanana ya amoxicillin.

Ma paracokinetic magawo a amoxicillin ndi clavulanic acid, omwe amapezeka mu maphunziro osiyana, pomwe odzipereka othamanga athanzi adatenga:

- Mapiritsi 2 Augmentin ®, 875 mg + 125 mg (1000 mg).

Magawo a pharmacokinetic oyambira

Amoxicillin mu kapangidwe ka mankhwala Augmentin ®

Augmentin ®, 875 mg + 125 mg

Clavulanic acid mu kapangidwe ka mankhwala Augmentin ®

Augmentin ®, 875 mg + 125 mg

Monga iv makuphatikiza a kuphatikiza amoxicillin ndi clavulanic acid, achire poyerekeza amoxicillin ndi clavulanic acid amapezeka osiyanasiyana matupi ndi interstitial fluid (ndulu )

Amoxicillin ndi clavulanic acid ali ndi malire ofooka a mapuloteni a plasma. Kafukufuku wasonyeza kuti pafupifupi 25% ya kuchuluka kwa clavulanic acid ndi 18% ya amoxicillin m'magazi am'magazi amaphatikizika ndi mapuloteni a plasma.

Mu maphunziro a nyama, palibe chowerengera cha zigawo za kukonzekera kwa Augmentin ® mu chiwalo chilichonse chomwe chinapezeka.

Amoxicillin, monga ma penicillin ambiri, amadutsa mkaka wa m'mawere. Zotsatira za clavulanic acid zimapezekanso mkaka wa m'mawere. Kupatula kuthekera kokhala ndi matenda otsegula m'mimba ndi candidiasis pamatumbo amkamwa, palibe zovuta zina za amoxicillin ndi clavulanic acid pa thanzi la makanda oyamwitsa.

Kafukufuku wothandizira kubereka kwanyama akuwonetsa kuti amoxicillin ndi clavulanic acid amawoloka chotchinga. Komabe, palibe zoyipa zilizonse pa mwana wakhanda zomwe zapezeka.

10-25% ya koyamba mlingo wa amoxicillin amamuchotsa impso ngati anafooka metabolite (penicilloic acid). Clavulanic acid imapangidwa modabwitsa kwambiri mpaka 2,5-dihydro-4- (2-hydroxyethyl) -5-oxo-3H-pyrrole-3-carboxylic acid ndi amino-4-hydroxy-butan-2-amodzi ndipo amachotsa kudzera mu impso. Matumbo am'mimba, komanso ndi mpweya womwe watha mwa mawonekedwe a mpweya woipa.

Monga ma penicillin ena, amoxicillin amathandizidwa ndi impso, pomwe clavulanic acid imachotsedwanso ndi machitidwe a impso komanso owonjezera.

Pafupifupi 60-70% ya amoxicillin ndi 40-65% ya clavulanic acid amuchotseredwa ndi impso osasintha pakapita maola 6 mutatenga tebulo limodzi. 250 mg + 125 mg kapena piritsi limodzi 500 mg + 125 mg.

Makonzedwe omwewo a probenecid amachedwetsa kuchoka kwa amoxicillin, koma osati clavulanic acid (onani "Kuchita").

Zowonetsa Augmentin ®

Kuphatikiza kwa amoxicillin ndi clavulanic acid akuwonetsedwa kuti azichiza matenda a bakiteriya a malo otsatirawa omwe amayamba chifukwa cha tizilombo tomwe timayang'ana pakuphatikizidwa kwa amoxicillin ndi clavulanic acid:

matenda apamwamba a kupuma thirakiti (kuphatikizapo matenda a ENT), mwachitsanzo. Streptococcus pneumoniae, Haemophilus fuluwenza 1, Moraxella catarrhalis 1 ndi Streptococcus pyogene, (kupatula mapiritsi a Augmentin 250 mg / 125 mg),

matenda am'munsi kupuma, monga kufalikira kwa chifuwa, chibayo, ndi bronchopneumonia, yomwe imayamba chifukwa Streptococcus pneumoniae, Haemophilus fuluwenza 1 ndi Moraxella catarrhalis 1,

matenda amkodzo thirakiti, monga cystitis, urethritis, pyelonephritis, matenda amtundu wamkazi, nthawi zambiri amayamba chifukwa cha mitundu ya banja Enterobacteriaceae 1 (makamaka Escherichia coli 1 ), Staphylococcus saprophyticus ndi mitundu Enterococcuskomanso chinzonono choyambitsidwa ndi Nisseria gonorrhoeae 1,

khungu ndi minofu yofewa matenda omwe amayambitsidwa nthawi zambiri Staphylococcus aureus 1, Streptococcus pyogene ndi mitundu Mabakiteriya 1,

matenda a mafupa ndi mafupa, monga osteomyelitis, omwe amayambitsidwa nthawi zambiri Staphylococcus aureus 1, ngati ndi kotheka, chithandizo cha nthawi yayitali nchotheka.

matenda a odontogenic, mwachitsanzo, periodontitis, odontogenic maxillary sinusitis, mano owoneka kwambiri ndi kufalikira kwa cellulitis (piritsi la Augmentin piritsi, mlingo wa 500 mg / 125 mg, 875 mg / 125 mg),

matenda ena osakanikirana (mwachitsanzo, kuchotsa mimba kwa septic, sepsis ya pambuyo pake) monga gawo lamankhwala othandizira (piritsi la Augmentin piritsi limodzi ndi 250 mg / 125 mg, 500 mg / 125 mg, 875 mg / 125 mg),

1 Oimira pawokha amtundu wa tizilombo tating'onoting'ono timatulutsa beta-lactamase, yomwe imawapangitsa kuti asamve chidwi ndi amoxicillin (onani. Pharmacodynamics).

Matenda oyambitsidwa ndi tizilombo tomwe timayamwa amoxicillin amatha kuthandizidwa ndi Augmentin ®, chifukwa amoxicillin ndi chimodzi mwazomwe zimagwira. Augmentin ® amasonyezedwanso zochizira matenda osakanikirana omwe amayambitsidwa ndi ma tizilombo tating'onoting'ono tokhala ndi amoxicillin, komanso ma tizilombo tating'onoting'ono timene timatulutsa beta-lactamase, tcheru limodzi ndi kuphatikiza kwa amoxicillin ndi clavulanic acid.

Mphamvu ya mabakiteriya kuphatikiza kwa amoxicillin ndi asidi wa clavulanic amasiyanasiyana malinga ndi dera komanso nthawi. Ngati kuli kotheka, zosowa zamderalo ziyenera kukumbukiridwa. Ngati ndi kotheka, zitsanzo za tizilombo ting'onoting'onoting'ono ziyenera kusungidwa ndikuwunikiridwa kuti mumve ma bacteria.

Mimba komanso kuyamwa

Mu maphunziro a ntchito za kubereka mu nyama, makamwa ndi utsogoleri wa Augmentin ® sizinayambitse zotsatira za teratogenic.

Pa kafukufuku m'modzi mwa azimayi omwe ali ndi matendawa zisanachitike, anapezeka kuti mankhwala a prophylactic ndi Augmentin ® akhoza kuphatikizidwa ndi chiopsezo chowonjezeka cha necrotizing enterocolitis mwa akhanda. Monga mankhwala onse, mankhwalawa a Augmentin ® samalimbikitsidwa kuti azigwiritsidwa ntchito panthawi yomwe ali ndi pakati, pokhapokha ngati phindu lomwe limayembekezera kwa mayi likupereka chiwopsezo cha mwana wosabadwayo.

Mankhwala Augmentin ® angagwiritsidwe ntchito poyamwa. Kupatula kuti mwina mungayambitse matenda otsegula m'mimba kapena maselo a mucous nembanemba amkamwa omwe amaphatikizidwa ndi kulowetsedwa kwa kuchuluka kwa zinthu zomwe zimachitika mu mankhwalawa mkaka wa m'mawere, palibe zovuta zina zomwe zidawonedwa mu makanda oyamwa. Pakakhala zovuta m'makanda oyamwitsa, kuyamwitsa kuyenera kusiyidwa.

Wopanga

SmithKlein Beach P.C. BN14 8QH, West Sussex, Vorsin, Clarendon Road, UK.

Dzinalo ndi adilesi ya bungwe lovomerezeka lomwe mayina awo alembedwa: GlaxoSmithKline Trading CJSC. 119180, Moscow, Yakimanskaya nab., 2.

Kuti mumve zambiri, kulumikizana: GlaxoSmithKline Trading CJSC. 121614, Moscow, st. Krylatskaya, 17, bldg. 3, pansi 5. Paki Yamalonda "Mapiri a Krylatsky."

Foni: (495) 777-89-00, fakisi: (495) 777-89-04.

Tsiku lotha ntchito la Augmentin ®

mafilimu okhala ndi mafilimu 250 mg + 125 mg 250 mg + 125 - zaka 2.

makanema okhala ndi mafilimu 500 mg + 125 mg - zaka 3.

makanema okhala ndi mafilimu 875 mg + 125 mg - zaka 3.

ufa w kuyimitsidwa pakakonzedwe kamlomo ka 125mg + 31.25mg / 5ml - zaka 2. Kuyimitsidwa okonzeka ndi masiku 7.

ufa woyimitsidwa pakumwa kwamlomo 200 mg + 28,5 mg / 5 ml 200 mg + 28,5 mg / 5 - 2 zaka. Kuyimitsidwa okonzeka ndi masiku 7.

ufa woyimitsidwa pakumwa kwamlomo 400 mg + 57 mg / 5 ml 400 mg + 57 mg / 5 - 2 zaka. Kuyimitsidwa okonzeka ndi masiku 7.

Osagwiritsa ntchito tsiku lotha ntchito likusonyezedwa pa phukusi.