Momwe mungagwiritsire ntchito mankhwala a Biosulin?

Mankhwalawa ali ndi mitundu itatu:

Jakisoni njira Biosulin P,
Kuyimitsidwa kwa sc makonzedwe a Biosulin N,
Kuyimitsidwa kwa sc makonzedwe a Biosulin 30/70.

Mililita imodzi ya jakisoni ili ndi 100 IU ya insulin yopangidwa mwanjira zosiyanasiyana, komanso zinthu zina zothandiza monga madzi a jakisoni, metacresol ndi glycerol.

Mililita imodzi ya kuyimitsidwa kwa Biosulin N ili ndi 100 IU yogwira ntchito ndi zina zowonjezera: zinc oxide, sodium hydrogen phosphate, protamine sulfate, crystalline phenol, metacresol, glycerol, jekeseni wamadzi.

Mililita imodzi ya kuyimitsidwa kwa 30/70 imakhala ndi zosakanikirana zama insulin zosiyanasiyana zolimbitsa thupi (zazifupi ndi zapakatikati): insulin yamadzimadzi yaumunthu ndi isofaninsulin ya anthu pamlingo wa 30:70.

Kutulutsa mafomu ndi kapangidwe kake

Biosulin P yomwe imayamba mwachangu ntchito yake imapangidwa mwanjira yothetsera jakisoni. 1 cm³ imakhala ndi 100 IU ml ya insulini yopangidwa pogwiritsa ntchito matekinoloje obadwa nawo. Kuphatikiza apo, kapangidwe kake kamankhwala kamaphatikizira glycerin, metacresol ndi madzi apadera a jekeseni. Ampoules ali mu paketi ya ma contour osiyanasiyana.

Biosulin H nthawi yayitali imapangidwa mwanjira yoyimitsa jakisoni pansi pa khungu. Ndi yoyera, yoyika pang'ono nthawi yosungirako. Imabwezeretsedwa mosavuta pakamagwedezeka.

Zotsatira za pharmacological

Timadzi timene timagwira ndi ma insulin receptor of the cell, chifukwa chomwe kusintha kwa shuga m'magazi kumachitika. Ndondomeko ya mayamwidwe ake ndi minofu yamatumbo imayendetsedwa, mapangidwe a glycogen amachitidwa, ndipo kupanga shuga m'magazi a chiwindi kumachepetsedwa.

Kukhazikika kwa ntchito yochita pakati pa Biosulin kuyambira 1 mpaka 2 maola. Zotsatira zazikulu zimachitika pambuyo pa maola 6-12, ndipo kutalika kwa zochitika kumafika mpaka maola 24.

Timadzi timene timagwira ndi ma insulin receptor of the cell, chifukwa chomwe kusintha kwa shuga m'magazi kumachitika.

Kukhazikika kwa hypoglycemic zochita kwa Biosulin posakhalitsa kuli pafupifupi mphindi 30. Chochulukitsa chachikulu pambuyo poti jakisoni wasungidwa mu maola 2-4, nthawi yayitali yochita ndi maola 6-8.

Zizindikiro zogwiritsidwa ntchito

Biosulin H akuwonetsedwa kuti agwiritsidwe ntchito kuzindikira matenda a shuga 1. Mtundu wachiwiri, amawerengedwa kwa odwala chifukwa chokana mankhwala osokoneza bongo omwe amachepetsa shuga.

Biosulin H akuwonetsedwa kuti agwiritsidwe ntchito kuzindikira matenda a shuga 1.

Ndi matenda ashuga

Mlingo wa tsiku ndi tsiku wa mankhwala umatsimikiziridwa kutengera mawonekedwe a wodwalayo. Ndikofunikira kuwerengetsa moyenera kuchuluka kwa insulin yakulemera kwa thupi. Mlingo wamba wa mankhwalawa patsiku amachokera ku 0,5 mpaka 1 IU, kutengera thupi la munthu. Insulin yokonzekera makonzedwe iyenera kukhala kutentha kwambiri. Nthawi zambiri, imayendetsedwa katatu patsiku, ndipo nthawi zina zochulukirapo. Ngati kuchuluka kwa tsiku ndi tsiku kupitilira 0,6 IU / kg, ndiye kuti muyenera kuchita jakisoni 2 mbali iliyonse ya thupi.

Mlingo wa tsiku ndi tsiku wa mankhwala umatsimikiziridwa kutengera mawonekedwe a wodwalayo.

Biosulin imalowetsedwa m'mimba, ntchafu, matako, minofu yolimba - paliponse pomwe pali mafuta okwanira. Masamba a jakisoni amasinthidwa kuti ateteze kukula kwa njira ya lipodystrophy.

Intramuscularly kutumikiridwa kokha moyang'aniridwa ndi katswiri. Nthawi zina amaphatikizidwa ndi insulin yapakatikati ya dzina lomweli. Kuyambitsa koteroko kumafunikira kuwunikira pafupipafupi kuchuluka kwa glycemia.

Njira yothandizira ma Biosulin imasiyana malinga ndi mtundu wa mankhwalawa omwe amagwiritsidwa ntchito. Mukamagwiritsa ntchito mtundu umodzi wokha wa insulini, matchulidwe ake amachitika motere:

Kuwonongeka kwa nembanemba pa botolo ndi ethanol kumachitika.
Lowetsani mpweya mu syringe muyezo wofanana ndi mlingo womwe wapatsidwa, ndikudzaza botolo ndi mpweya wofanana.
Mutembenuzire pansi ndi kuyimba muyeso wa Biosulin kale.
Chotsani singano, chotsani mpweya ku syringe. Onetsetsani kuti kuyimba ndi kolondola.
Pangani jakisoni.

Mukamagwiritsa ntchito mitundu iwiri yamankhwala, wodwala azichita motere:

Kuwonongeka kwa utoto womwe umapezeka mabotolo amachitika.
Muyenera kusunthira botolo ndi insulin yayitali mpaka yankho lake likhale ndi mtundu wofanana (osati loyera).
Jambulani mpweya mu syringe molingana ndi kuchuluka kwa insulini yapakatikati kapena yayitali. Singano imayikidwa mu beseni ndi insulin, ndikutulutsa mpweya ndikutulutsa singano. Pakadali pano, insulini yapakatikati kapena yayitali simalowa syringe.
Jambulani mpweya mu syringe momwe insulin yayifupi imayambira. Tulutsani mpweya mu botolo ili. Tembenuzani ndi kujambula kuchuluka kwamankhwala.
Chotsani singano, chotsani mpweya wambiri. Chongani mlingo woyenera.
Bwerezani zomwezo, mutenge insulini yapakatikati kapena yayitali kuchokera ku vial. Chotsani mpweya.
Pangani jakisoni kuchokera ku zosakaniza za insulin.

Pambuyo pa jekeseni, siyani singano pansi pa khungu pafupifupi masekondi 6.

Chidacho chimatha kupangidwa mu cartridge yomwe ili ndi cholembera cha syringe ndi singano, 5 ml. Cholembera chimayikidwa 3 ml ya insulin. Musanagwiritse ntchito, onetsetsani kuti ndi lopanda chilema. Kathumba katayikidwa mu syringe, Mzere uyenera kuwonekera kudzera pazenera lake la wogwirizira.

Pambuyo pa jekeseni, siyani singano pansi pa khungu pafupifupi masekondi 6. Nthawi yonseyi batani limasungidwa pamalo okhazikika, kotero kulondola kwa mlingo kumatsimikizika. Pambuyo pa nthawi iyi, chogwiriracho chimatha kuchotsedwa mosamala. Katiriji sikakapangidwira kuti mwatsoka;

Mapeto a insulin, ayenera kutayidwa.

Kuchokera kumbali ya kagayidwe

Zimatha kuyambitsa hypoglycemic. Munthu atha kuona zotsatirazi:

khungu komanso zimagwira pakhungu.
kutuluka thukuta kwambiri
palpitations
minofu ikunjenjemera
kumva ludzu lakuthwa,
kusangalala kwakukuru, nthawi zina kupsa mtima, mkwiyo, kusokonekera komanso chisokonezo chamalingaliro,
malungo
kupweteka m'mutu,
kuphwanya kwamitsempha.

Kuchokera pa kutenga Biosulin, pamatha kuchuluka kwa thukuta.
Kutenga Biosulin, kumatha kumamveka kugunda kwamtima pafupipafupi.
Kuchokera pa kutenga Biosulin pamatha kupweteka m'mutu.

Hypoglycemia yemwe amakhala atasungidwa nthawi yayitali kumatha kupangitsa kuti akhale ndi vuto la kuchepa kwa magazi:

khungu ndi chinyezi cha pakhungu,
kuchuluka kwamtima,
chinyezi cha lilime
kuchuluka kwamisempha,
kupuma kosakhazikika komanso kupumira mwachangu.

Wakupweteka kwambiri, wodwalayo sakomoka. Samva kudzikirira, kamvekedwe ka minofu kachepa, thukuta limaleka, kugunda kwa mtima wake kwakwiya. Kulephera kupuma. Vuto lowopsa kwambiri la hypoglycemic coma ndi mitsempha ya m'magazi, yomwe imatsogolera kumangidwa kupuma.

Ndi kupanga izi, ndikofunikira kuti mupeze chithandizo chamankhwala panthawi yake. Mwapang'onopang'ono kuperekedwa, munthu sangathe kukhala ndi vuto loyipa la hypoglycemic. Kukhazikitsidwa kwa insulin mdziko la kuchepetsa magazi m'magazi kumakhala ndi zotsatira zoyipa za odwala matenda ashuga.

Hypoglycemia yomwe imakhalapo kwa nthawi yayitali imatha kupangitsa munthu kukhala ndi vuto la kuchepa kwa magazi.

Ndi jakisoni maphunziro a Biosulin mankhwala, matupi awo sagwirizana: zotupa khungu, edema, zosowa - anaphylactoid zimachitika. Zomwe zimachitika mdera lanu mujekeseni mungayambitse - kuyabwa, kufupika, komanso kutupa pang'ono.

Malangizo apadera

Ndi koletsedwa kugwiritsa ntchito mankhwalawo ngati asintha mtundu kapena tinthu tating'onoting'ono taoneka. Pa mankhwala, muyenera kuwona kuchuluka kwa glucose m'magazi. Zomwe zimawoneka ngati hypoglycemia ndi:

kutsatsa insulin
kukakamizidwa kufa ndi njala
kuchuluka kwambiri kwa zolimbitsa thupi.
matenda omwe amachepetsa kufunika kwa insulini (mwachitsanzo, kukanika kwa impso ndi chiwindi, kuchepa kwa adrenal ntchito, chithokomiro cha chithokomiro kapena gland pituitary),
kusintha kwa jakisoni,
mogwirizana ndi mankhwala ena.

Chimodzi mwazinthu zomwe zimawoneka ngati hypoglycemia ndi kuwonjezeka kwambiri kwa zolimbitsa thupi.Chimodzi mwazinthu zomwe zimawoneka ngati hypoglycemia ndi kucheza ndi mankhwala ena.Chimodzi mwazinthu zomwe zimawoneka ngati hypoglycemia ndi kukakamizidwa kufa ndi njala.

Kuphwanya jekeseni wa biosulin mwa odwala matenda a shuga omwe amadalira insulin kumabweretsa kukula kwa hyperglycemia. Mawonekedwe ake:

kamwa yowuma
kukodza pafupipafupi
kusanza ndi kusanza,
redness la pakhungu ndi mucous nembanemba
kuchepa kwamtima
kununkhira kwa ma acetone ndi maapulo akhathamira mumlengalenga.

Hyperglycemia yamtunduwu wa shuga popanda chithandizo chokwanira imatha kubweretsa ketoacidosis.

Kusintha kwa mlingo wa Biosulin kumachitika ndi:

kuchuluka kwa katundu,
matenda opatsirana
Matenda a Addison
zovuta zam'mimba
vuto la chiwindi
kusintha kwa zakudya.

Kusintha kwa mlingo wa Biosulin kumachitika ndi matenda opatsirana.
Kusintha kwa mlingo wa Biosulin kumachitika ndi kusintha kwa zakudya.
Kusintha kwa mlingo wa Biosulin kumachitika ndi kuwonjezeka kwa kuchuluka kwa katundu.

Sizoletsedwa kubaya insulin ya nthawi yayitali pakuyimitsidwa ngati, chifukwa chogwedezeka, imayeretsa ndipo imakhala opaque. Homoni wotereyu ndi woipa ndipo amatha kuyambitsa poizoni. Kugwiritsa ntchito mankhwalawa kumapampu a insulin sikuchitika.

Mankhwala osokoneza bongo a Biosulin

Ngati mulingo wapitirira, hypoglycemia imatha kuchitika. Kuperewera kwa glucose ofatsa kumachotsedwa pakudya shuga kapena zakudya zopatsa mphamvu. Anthu omwe ali ndi matenda ashuga amafunika kukhala ndi maswiti kapena zakudya zilizonse zopatsa mphamvu zamagetsi nthawi zonse.

Amafuna kusintha kwamankhwala mwa anthu azaka zopitilira 65.

Ndi chikomokere, Dextrose amalowetsedwa m'mitsempha, glucagon s / c, kulowa mu mtsempha kapena minofu. Wodwalayo akangochira, ayenera kudya zakudya zamafuta a shuga.

Kuchita ndi mankhwala ena

Pali mankhwala omwe amakhudza kufunika kwa odwala matenda ashuga a insulin. Kutsitsa kwa shuga kwa mankhwalawa kumatheka:

mankhwala ochepetsa shuga omwe amagwiritsidwa ntchito ngati shuga mkati,
Mao zoletsa mankhwala
β-blockers
ACE zoletsa
sulfonamides,
ma steroid ndi ma anabolics,
kaboni anhydrase ntchito zoletsa,
Bromocriptine
Pyridoxine
Octreotide
Ketoconazole,
Mebendazole,
Theofylline
Tetracycline
othandizira okhala ndi mankhwala a lithiamu
mankhwala onse okhala ndi ethyl mowa.

Mphamvu yochepetsera shuga ya mankhwala omwe amapanga bromocriptine.
Mphamvu yochepetsera shuga ya mankhwala osokoneza bongo Octreotide.
Mphamvu yochepetsera shuga ya mankhwala omwe amachititsa pyridoxine.

Zotsatira zotsatirazi zimachepetsa ntchito ya Biogulin:

mankhwala othandizira kulera
GKS,
chithokomiro
okodzetsa a mndandanda wa thiazide,
Heparin
antidepressants
othandizira achifundo
Clonidine hydrochloride,
zikutanthauza kuti choletsa ntchito yama calcium tubules,
Morphine
Phenytoin.

Kusuta kumathandizira kuchepetsa hypoglycemic zotsatira za Biosulin.

Kuyenderana ndi mowa

Imachepetsa kukana kwa thupi ndi ethanol.

Ma Analogs amtundu wotengedwa wa insulin ndi:

Tileke,
Gensulin
Isulin insulin
Insuran
Protamine insulin
Protafan
Rinsulin
Rosinsulin,
Humulin
Humulin-NPX.

Protamine-insulin ndi amodzi mwa fanizo la Biosulin.
Rinsulin ndi amodzi mwa fanizo la Biosulin.
Rosinsulin ndi amodzi mwa fanizo la Biosulin.

Ndemanga za biosulin

Irina, wazaka 40, wodwala matenda a m'mimba, a Samara: "Kuti ndikonze shuga, ndimayikira odwala omwe ali ndi mankhwala osokoneza bongo a Biosulin mwachangu. Mankhwalawa amaloledwa bwino ngati mulingo ndi nthawi yoyendetsera imawerengedwa molondola, zotsatira zoyipa sizikuwoneka. masiku, zomwe zikuwonetsa kubwezera kwabwino kwabwino kwa matenda ashuga. "

Svetlana, wazaka 38, endocrinologist, Rostov-on-Don: "Mtundu wa insulini wothandiza odwala omwe ali ndi matenda a shuga omwe amadalira insulin. Pazomwezi, mtundu wachangu wa mankhwalawa umaperekedwa, chifukwa ndikofunikira kulipiritsa kulumpha kwa glucose musanadye. Zimathandizira kuwongolera bwino shuga tsiku lonse. "

Malangizo a Biosulin N Momwe mungasankhire insulin yayitali?

Sergey, wazaka 45, ku Moscow: "Ndimatenga Biosulin P ngati imodzi mwa mitundu yochepa ya insulin. Imachitika mkati mwa theka la ola, ndiye kuti, kuyang'anira mankhwalawa kumatha kulumikizidwa mosavuta ndi chakudya chilichonse. Nthawi zonse ndimawerenga kuchuluka kwa insulin kutengera kulemera kwanga ndi kuchuluka kwa chakudya, chifukwa chake zochitika za hypoglycemia ndizosowa. Palibe zovuta zina. "

Irina, wazaka 38, St. Petersburg: "Ndimatenga Biosulin H ngati imodzi mwazosiyanasiyana za insulini yokhala ndi sing'anga. Ndimakonda kugwiritsa ntchito ma syringe ena apadera: ndi otetezeka komanso odalirika. Nthawi zonse ndimawerengera molondola kuchuluka kwa mankhwalawo ndikuwamwetsa molingana ndi malangizo omwe aphatikizidwa. Palibe zotsatira zoyipa zilizonse. , zigawo za hypoglycemia nthawi zina zimachitika. Ndaphunzira kuzizindikira ndikuziletsa pakapita nthawi. "

Anthu odwala matenda ashuga

Igor, wazaka 50, Ivanovo: "Ndimagwiritsa ntchito Biosulin ya sing'anga komanso yochepa pakuchiza matenda a matenda a shuga. Ngati kuli koyenera, ndimapaka jekeseni imodzi. Mankhwalawa amathandizira mwachangu komanso samayambitsa shuga, ngati pakanalibe zolemetsa kapena nkhawa m'mbuyomu Ndili ndi chakudya komanso jakisoni wa insulin. Zonsezi zimapangitsa shuga wanga kukhala wabwinobwino. "

Mlingo ndi makonzedwe

Biosulin P yakonzedwa kuti kayendetsedwe ka SC, IM ndi IV. Kuwerengera kwa mlingo ndi njira yothandizira makonzedwe a mankhwala amatsimikizika kutengera ndi zomwe zikuwonetsa kuchuluka kwa shuga m'magazi ndi machitidwe a wodwala.

Malinga ndi malangizo, pafupifupi tsiku lililonse mlingo umasiyana ndi 0,5 mpaka 0 IU pa kilogalamu ya wodwala thupi.

Njira yothetsera kapena kuyimitsidwa imalimbikitsidwa kuti iperekedwe katatu patsiku theka la ola musanadye kapena osaneneka pogwiritsa ntchito mankhwala okhala ndi chakudya. Muzochitika izi zikafunika, pafupipafupi njira zimachulukitsa mpaka 5 kapena 6. Ngati mlingo wa tsiku ndi tsiku umaposa 0.6 IU, yankho limayendetsedwa ndi jekeseni osachepera awiri m'magawo osiyanasiyana a thupi.

Monga lamulo, Biosulin mwa njira yothetsera imayikidwa kuti idindidwe pansi pa khungu la khoma lakumbuyo kwamkati. Kuyimitsidwa ndikulimbikitsidwa kuti liperekedwe mu ntchafu.

Popewa kukula kwa lipodystrophy (kuchepa kwamafuta), ndikofunikira kusintha tsamba la jekeseni mkati mwa dera lomwe limalimbikitsa. Jekeseni amaloledwa kuchitidwa khoma lam'mimba, dera lokhala ndi minofu ya phewa, ntchafu kapena matako.

Asanagwiritse ntchito, biosulin iyenera kuzitenthetsera kutentha kwa firiji. Jakisoni amachitika bwino kwambiri pakhungu, chifukwa izi zimachepetsa chiwopsezo cha mankhwala kulowa mu minofu.

Popeza yankho Biosulin P ndi insulin yochepa, imakonda kugwiritsidwa ntchito limodzi ndi kukonzekera kwapakati (kuyimitsidwa Biosulin H kapena 30/70).

Mu / m ndi mu / pakukhazikitsa kwa mankhwala mu mawonekedwe a jekeseni wololeza amaloledwa kokha moyang'aniridwa ndi dokotala.

Ngati ndi kotheka, chisamaliro chachikulu Biosulin N chitha kugwiritsidwa ntchito kamodzi kapena kawiri patsiku ngati insulin (maziko) a insulin. Monga lamulo, limayendetsedwa ngati othandizira monotherapeutic m'mawa komanso madzulo, chakudya chamasana chisanayambike ndikulimbikitsidwa kuti mupeze kuyimitsidwa pamodzi ndi insulin yochepa.

Zotsatira zoyipa

Pakuwakhudza kagayidwe kazakudya m'thupi, Biosulin imatha kuyambitsa kukula kwa zinthu zam'magazi, zomwe zimawonetsedwa ndi khungu lotuwa, kuchuluka thukuta, kunjenjemera, njala, palpitations, kupweteka kwa mutu, paresthesia (kugunda, dzanzi ndi kukwawa) mkamwa.

Pankhani ya hypoglycemia yayikulu, wodwalayo angagwe pachiwopsezo cha hypoglycemic.

Zotsatira zoyipa za Biosulin zomwe zikuwonetsedwa mu mankhwalawa ndizomwe zimayambitsa khungu: zotupa za pakhungu, edema ya Quincke, kawirikawiri anaphylactic kugwedezeka) komanso zam'deralo (hyperemia, kuyabwa, kupweteka kwa malo a jekeseni). Kugwiritsa ntchito mankhwala kwa nthawi yayitali kungayambitse kukula kwa lipodystrophy.

Palinso umboni wa mawonekedwe a edema komanso zolakwika zoyenda pang'onopang'ono, zomwe nthawi zambiri zimadziwika m'magawo oyambira a mankhwala a Biosulin.

Migwirizano ndi magwiritsidwe akusungidwa

Mankhwalawa amayenera kusungidwa pamalo amdima osavomerezeka kwa ana pa kutentha kwa 2 mpaka 8 ºº. Osati kuzizira!

Moyo wa alumali ndi miyezi 24. Mutatsegula botolo, zomwe zili mkati mwake ziyenera kugwiritsidwa ntchito mkati mwa masabata 6. Botolo lotseguka limasungidwa kutentha kwa 15 mpaka 25 ºº.

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