Momwe mungagwiritsire ntchito mankhwala Gluconorm Plus?

- matenda ashuga ketoacidosis, matenda a shuga, matenda a shuga,

- kwambiri aimpso kuwonongeka,

- pachimake zinthu zomwe zingayambitse kusintha kwa impso (kuchepa madzi, matenda akulu, mantha),

- matenda owopsa kapena osakhazikika omwe amatsatana ndi minyewa hypoxia (mtima kapena kupuma, kutulutsa kwa myocardial kwaposachedwa, mantha),

- matenda opatsirana, chithandizo chachikulu chopangira opaleshoni, kuvulala, kuwotcha kwakukulu ndi zina zomwe zimafuna chithandizo cha insulin,

- uchidakwa wambiri, kuledzera kwambiri,

- lactic acidosis (kuphatikizapo mbiri),

- gwiritsani ntchito maola osachepera 48 isanachitike komanso mkati mwa maola 48 mutapanga maphunziro a radioisotope kapena X-ray ndikukhazikitsa ma iodine okhala ndi zosiyana pakati,

- kutsatira zakudya zochepa zopatsa mphamvu (zosakwana 1000 calories / tsiku),

- nthawi yoyamwitsa,

- Hypersensitivity to metformin, glibenclamide kapena zinthu zina za sulfonylurea, komanso zinthu zothandiza.

Momwe mungagwiritsire ntchito: Mlingo ndi njira ya chithandizo

Mkati, ndikudya.

Nthawi zambiri mlingo woyambirira ndi 1 tabu. (400 mg / 2.5 mg) / tsiku. Pakadutsa milungu iwiri ndi inayi atayamba kumwa mankhwalawa, mankhwalawa amathandizidwa malinga ndi kuchuluka kwa shuga m'magazi. Mukamachotsa mankhwala ophatikizira am'mbuyomu ndi metformin ndi glybeklamide, mapiritsi 1-2 amapatsidwa. Gluconorm kutengera mtundu wapitawo wa chilichonse.

Pazipita tsiku lililonse mapiritsi 5.

Zotsatira za pharmacological

Glibenclamide imalimbitsa katemera wa insulini pochepetsa kutsekeka kwa glucose beta-cell pancreatic mkwiyo, imakulitsa chidwi cha insulini komanso kuchuluka kwake komwe kumangiriza maselo.

Metformin imachepetsa shuga wa seramu pakuwonjezera chidwi cha zotumphukira kuti insulini ipititse patsogolo kukweza kwa glucose.

Zotsatira zoyipa

Pa gawo la kagayidwe kazakudya: hypoglycemia ndiyotheka.

Kuchokera m'mimba thirakiti ndi chiwindi: kawirikawiri - nseru, kusanza, kupweteka m'mimba, kusowa chilakolako cha chakudya, "kukomoka kwachitsulo" mkamwa, nthawi zina - cholestatic jaundice, kuchuluka kwa michere ya chiwindi, hepatitis.

Kuchokera ku hemopoietic dongosolo: kawirikawiri - leukopenia, thrombocytopenia, erythrocytopenia, kawirikawiri - agranulocytosis, hemolytic kapena megaloblastic anemia, pancytopenia.

Thupi lawo siligwirizana ndi immunopathological: kawirikawiri - urticaria, erythema, kuyabwa khungu, kutentha thupi, arthralgia, proteinuria.

Dermatological zimachitika: kawirikawiri - photosensitivity.

Kuchokera kumbali ya kagayidwe: lactic acidosis.

Malangizo apadera

Kuchitapo kwakukulu kwa maopareshoni ndi kuvulala, kuwotcha kwakukulu, matenda opatsirana omwe ali ndi febrile syndrome kungafune kuleka kwa mankhwalawo ndi kuikidwa kwa mankhwala a insulin.

Ndikofunikira kuyang'anira kuchuluka kwa shuga m'magazi pamimba yopanda kanthu ndikatha kudya.

Odwala ayenera kuchenjezedwa za chiwopsezo chowonjezereka cha hypoglycemia milandu ya ethanol, NSAIDs, ndi njala.

Kuchita

Ethanol imawonjezera mwayi wa lactic acidosis.

Barbiturates, corticosteroids, adrenostimulants (epinephrine, clonidine), antiepileptic mankhwala (phenytoin), wosakwiya calcium njira blockers, carbonic anhydrase inhibitors (acetazolamide), thiazide diuretics, chlortalidone, furosemide, diazanazide , morphine, ritodrine, salbutamol, terbutaline, glucagon, rifampicin, mahomoni okhala ndi chithokomiro, mchere wa lithiamu, muyezo waukulu - nicotinic acid, chlorpromazine, kulera kwapakamwa komanso estrojeni.

ACE inhibitors (Captopril, enalapril), histamine H2 receptor blockers (cimetidine), antifungal agents (miconazole, fluconazole), NSAIDs (phenylbutazone, azapropazone, oxyphenbutazone), ma fibrate, ma antibayotiki (clobate) , salicitates, coumarin anticoagulants, anabolic steroids, beta-blockers, mao inhibitors, sulfonamides wa nthawi yayitali, cyclophosphamide, chloramphenicol, phenfluramine, fluoxetine, guanethidine, pentoxifylline, tetracycline, theophylline, tubular secretion blockers, reserpine, bromocriptine, disopyramide, pyridoxine, mankhwala ena a hypoglycemic (acarbose, biguanides, insulin), allopurinol.

Mafunso, mayankho, ndemanga pa mankhwala Gluconorm Plus

Zomwe zimaperekedwa zimakonzekera akatswiri azamankhwala komanso zamankhwala. Chidziwitso chokwanira chokhudza mankhwalawa chili m'malangizo omwe aphatikizidwa ndi wopanga. Palibe chidziwitso chomwe chatumizidwa patsamba lino kapena tsamba lililonse la tsamba lathu chomwe chingagwire ntchito ngati cholowa m'malo mwapadera kwa katswiri.

Kutulutsa mafomu ndi kapangidwe kake

Mankhwala amapezeka mwa mawonekedwe a mapiritsi. Muli zosakaniza: glibenclamide ndi metformin hydrochloride. Mlingo piritsi limodzi, 2,5 ndi 5 mg, 500 mg. Kuphatikiza pa kuphatikiza zinthu izi, kaphatikizidwe kamaphatikizanso zigawo zothandizanso pamitunduyi pamtunduwu wamasulidwe:

• cellcrystalline mapadi,
• Hyprolose
• sodium croscarmellose,
• magnesium wakuba.

Mapiritsiwa amakhala ndi zokutira zapadera zomwe zimachepetsa mtengo wa kumasulidwa kwa zinthu zomwe zimagwira. Chifukwa cha izi, kuchuluka kwaukali pazomwe zimapanga mucous m'mimba kumachepa. Mutha kugula malonda mumapaketi okhala ndi miyala 30.

Mankhwala amapezeka mwa mawonekedwe a mapiritsi. Muli zosakaniza: glibenclamide ndi metformin hydrochloride.

Pharmacokinetics

Metformin imalowa mwachangu. Mlingo wa kuchuluka kwake m'magazi seramu ukuwonjezeka mpaka kumapeto kwa maola 2. Zoyipa zamtunduwu ndizofunikira mwachidule. Pambuyo pa maola 6, kuchepa kwa plasma ndende ya metformin kumayamba, zomwe zimachitika chifukwa cha kutha kwa njira yonyowetsera chakudya m'mimba. Hafu ya moyo wa chinthucho imachepetsedwa. Kutalika kwake kumasiyana kuchokera ku 1.5 mpaka 5 maola.

Kuphatikiza apo, metformin sikugwirizana ndi mapuloteni a plasma. Izi zimatha kudzikundikira mu minyewa ya impso, chiwindi, tiziwalo tamadonthina. Kuwonongeka kwa impso ndi chinthu chachikulu chomwe chikuthandizira kuchulukana kwa metformin mthupi, zomwe zimapangitsa kuti chiwonjezere cha gawo ili komanso kuwonjezereka kwa ntchito yake.

Ntchito yaimpso yolakwika ndi chinthu chachikulu chomwe chimathandizira kudziunjikira kwa metformin mthupi, zomwe zimapangitsa kuti chiwonjezere chofunikira.

Glibenclamide imatenga nthawi yayitali - kwa maola 8-12. Kuchuluka kwa mphamvu kumachitika mu maola 1-2. Katunduyu amakhala womangika ndi mapuloteni amwazi. Njira yosinthira kwa glibenclamide imachitika m'chiwindi, pomwe mapangidwe awiri amapangidwa omwe samawonetsa ntchito za hypoglycemic.

Zizindikiro zogwiritsidwa ntchito

Mankhwala amaloledwa kugwiritsidwa ntchito pochiza odwala omwe ali ndi matenda a shuga a 2 nthawi zina:

• kusowa kwa zotsatira ndi mankhwala omwe adalembedwa kale kunenepa, ngati pali ena mwa mankhwalawa: Metformin kapena Glibenclamide adagwiritsidwa ntchito,
• kuchitira mankhwala othandizira, m'malo mwake kuchuluka kwa glucose m'magazi ndikokhazikika ndikuwongolera bwino.

Kutulutsa Fomu

Gluconorm imapangidwa ngati mapiritsi ozungulira amithunzi yoyera yokhala ndi nembanemba. 10 ndi 20 zidutswa mumunyolo wazovala, matuza awiri kapena anayi mumakatoni.

Mtengo wa gluconorm umachokera ku ma ruble 220 mpaka 390, kutengera kuchuluka kwa mapiritsi okhala phukusi la makatoni.

Mankhwalawa ali ndi zinthu ziwiri zazikulu - glibenclamide (2.5 mg) ndi metformin hydrochloride (0,4 g).

Zowonjezera zina: cellcrystalline cellulose, wowonda wa chimanga, colloidal silicon dioxide, kuyeretsedwa kwa talc, diethyl phthalate, gelatin, cellulose acetate phthalate, sodium carboxymethyl, sodium croscamellose.

Malangizo ogwiritsira ntchito

Mapiritsi a Gluconorm amatengedwa pakamwa pakudya. Mlingo umatsimikiziridwa payekha, kutengera kuchuluka kwa shuga m'magazi a wodwalayo. Mlingo wokhazikika kumayambiriro kwa mankhwalawa ndi piritsi limodzi patsiku. Pambuyo pa masabata awiri, ndikofunikira kusintha mlingo wa mankhwalawa kutengera mtundu wa kuyesedwa kwa magazi.

Malangizo ogwiritsira ntchito Gluconorm akuwonetsa kuti pogwiritsa ntchito mankhwala othandizira amafunika kutenga mapiritsi a 1-2, mukuganizira mozama za zigawo zikuluzikulu. Mlingo waukulu patsiku umafikira mapiritsi 5.

Mapiritsi a Hypoglycemic ndi mankhwala. Iyenera kusungidwa pamatenthedwe mpaka madigiri 25 mu mawonekedwe a mwana, dzuwa lowongoka. Alumali moyo wa chinthucho ndi miyezi 36 kuyambira tsiku lopangira.

Zolemba ntchito

M'pofunika kuletsa chithandizo ndi mankhwalawa chifukwa cha matenda opatsirana omwe ali ndi malungo, ndi kuvulala kwambiri komanso kulowererapo. Chiwopsezo chochepetsera kuchuluka kwa shuga panthawi yanjala, kugwiritsa ntchito NSAIDs, Mowa umachulukitsidwa. Kusintha kwa Mlingo kumachitika posintha zakudya, mphamvu zamakhalidwe ndi kutopa.

Kuzindikira kwa shuga - ingomwani tsiku lililonse.

Malangizo omwe Gluconorm amafotokozera sakulimbikitsidwa kumwa mowa panthawi yamankhwala. Mapiritsi amatha kuthana ndi kuthamanga kwa zochitika zama psychomotor ndikuchepetsa chidwi. Chifukwa chake, muyenera kusamala mukamayendetsa magalimoto owopsa ndi magalimoto.

Sizoletsedwa kumwa mapiritsi ali mwana, panthawi yoyembekezera, poyamwitsa, chifukwa zinthu zikuluzikulu zimalowa mkaka wa mayi. Mankhwalawa amadziwikiratu anthu omwe ali ndi matenda a impso ndi chiwindi. Kugwiritsa ntchito mapiritsi okalamba sikulimbikitsidwa pamodzi ndi kuchita masewera olimbitsa thupi.

Bongo

Kudzilanga nokha komanso kupitirira muyeso wovomerezeka kumabweretsa kuchuluka kwa mankhwalawa. Izi zimatsogolera ku mawonekedwe a lactic acidosis chifukwa cha metformin, yomwe ndi gawo lamankhwala. Wodwalayo amawona mawonekedwe a nseru, kusanza, kufooka, kukokana kwa minofu. Ndi chizindikiro choyambirira cha bongo, mankhwala amathetsedwa. Ndi lactic acidosis, chithandizo chimachitika kuchipatala. Chithandizo chothandiza kwambiri ndi hemodialysis.

Timapereka kuchotsera kwa owerenga tsamba lathu!

Kuphatikizikako kumakhala ndi glibenclamide, ndende yambiri yomwe imayambitsa kukula kwa hypoglycemia. Zizindikiro zazikulu za izi:

• mutu
• chizungulire
• kulakalaka
• kufooka wamba
• kutsika kwa khungu,
• mantha
• zovuta zamitsempha,
• arrhasmia,
• kugona
• zovuta zamgwirizano
• maloto oyipa
• paresthesia pamimba.

Ndi kuchulukitsa kwa hypoglycemia, kuwonongeka kwa mkhalidwe wa wodwalayo, kulephera kuwongolera ndi kuzindikira kumawonedwa. Ndi kuwonda komanso kuthana kwamatenda, shuga amadziwika. M'malo owawa kwambiri, mukamazindikira kuti mwayamba kugwiritsa ntchito shuga, 40% shuga kapena glucagon amagwiritsidwa ntchito. Popewa kuwonekeranso kwa hypoglycemia, wodwalayo ayenera kudya chakudya chambiri chokhala ndi chakudya pambuyo pake.

Mankhwalawa atha kusinthidwa ndimankhwala monga Bagomet Plus ndi Glukovans. Zogulitsazi zimakhala ndi mawonekedwe ofanana ndi Gluconorm. Mapiritsi monga Glucofage ndi Glybomet ndi zithunzi za Gluconorm zomwe zimakhala ndi metformin. Ndi oletsedwa kugwiritsa ntchito mankhwala ena popanda mankhwala a dokotala kuti mupewe zovuta komanso kuti muchepese mkhalidwe wa wodwalayo.

Mapiritsi amathandiza odwala ena, pomwe ena amayambitsa mavuto. Pansipa pali ndemanga za odwala matenda ashuga Gluconorm.

Ndinapezeka ndi matenda ashuga zaka 7 zapitazo. Dotolo wamulembera Gluconorm ngati mankhwala obwezeretsa. Ndimamwa piritsi limodzi patsiku, ndimatsukidwa ndimadzi. Ndikumva bwino. Chithandizo changa chimaphatikizapo kumwa mankhwala, kudya. Pakadali pano, palibe mawonekedwe oyipa omwe adadziwika.

Ndili ndi matenda a shuga, adandiuza kuti ndizimwa Gluconorm tsiku lililonse m'mawa ndi madzulo. Glucose m'magazi idabwereranso mwabwinobwino, koma mutu wowopsa ndi kupukusa m'mimba zidawonekera. Zotsatira zake, ine ndatsutsana ndi mankhwalawa. Ndinafunika kusintha mankhwalawo.

Matenda a shuga nthawi zonse amayambitsa zovuta zakupha. Mwazi wamagazi ochulukirapo ndi woopsa kwambiri.

Aronova S.M. adafotokoza za chithandizo cha matenda ashuga. Werengani kwathunthu

Gulu la mankhwala

Kuphatikizidwa kwa Gluconorm kumaphatikizapo magawo awiri, omwe palimodzi amapereka mphamvu ya hypoglycemic.

Metformin ndi m'gulu la Biguanides, omwe amachititsa kuti maselo azikhala ndi insulin, zomwe zimapangitsa kuti shuga agwiritsidwe ntchito mwachangu. Izi zimakhudza kagayidwe kachakudya njira mu chiwindi, kukhalabe moyenera pakupanga kolesterol ndi triglycerol. Kuyamwa kwa chakudya cham'mimba kumachepetsedwa.

Glibenclamide ndi mtundu wa sulfonylurea. Ndi chithandizo chake, insulin secretion imachitika, yomwe imatheka chifukwa chokhala ndi maselo a pancreatic. Amawonjezera kukhudzika kwa maselo amthupi kuti apange insulin, kuletsa lipolysis ya minofu ya adipose.

Mlingo ndi makonzedwe

Mlingo woyenera kwambiri wa mankhwalawa umatsimikiziridwa ndi dokotala, kutengera zomwe zimawonetsa shuga. Chithandizo cha mankhwalawa chimayamba ndi kuchuluka kwa mankhwalawa, omwe ndi theka la piritsi kamodzi patsiku.

Pofuna kupewa kukula kwa hypoglycemia, tikulimbikitsidwa kumwa piritsi limodzi la mankhwala 1 nthawi patsiku ndi chakudya. Izi zimachitika bwino m'mawa, chifukwa cha kutsika pang'ono kwa kagayidwe kazakudya pambuyo pa nkhomaliro.

Pokhapokha pakugwira ntchito, mlingo umakulitsidwa pang'onopang'ono. Pazipita mlingo tsiku lililonse sayenera kupitilira mapiritsi a 5-6. Ngati pakufunika kugwiritsa ntchito Mlingo wokwera kuposa momwe analimbikitsira, wodwalayo ayenera kuyang'aniridwa pafupipafupi ndi akatswiri.

Gluconorm kuphatikiza

Kuchuluka kwa Glibenclamide kumakuthandizani kuti mugwiritse ntchito piritsi limodzi lokha patsiku kuti mupeze khola la hypoglycemic. Ndi mtundu wanji wa mankhwala omwe ali oyenera pazochitika zina, adokotala adzakuuzani.

Kodi mapiritsi a gluconorm kuphatikiza amawoneka bwanji?

Nthawi zambiri, chithandizo chimayamba ndi Gluconorm yokhazikika, posakhazikika pomwe amasinthana ndi fomu yolimbikitsidwa yomwe ili ndi mawonekedwe ambiri a Glibenclamide.

Kuyanjana kwa mankhwala osokoneza bongo

Kugwiritsa ntchito nthawi yomweyo mankhwala a Gluconorm kuphatikiza ndi Miconazole, komanso mankhwala ena aliwonse a antimycotic, omwe, akamacheza, amakhumudwitsa kukula kwa chikomokere cha matenda ashuga, mpaka zotsatira zake zakupha.

Osamamwa gluconorm ndi mowa

Simungagwiritse ntchito othandizira a hypoglycemic limodzi ndi mowa, zomwe zimayambitsa kuchepa kwa magazi ndi kuthamanga kwa mtima.

Mosamala kwambiri, mankhwalawa amaphatikizidwa ndi glucocorticosteroids ndi mankhwala, omwe amaphatikizapo ayodini.

Mawonekedwe akugwiritsidwa ntchito

Gluconorm siyikulimbikitsidwa kwa odwala atakwanitsa zaka 65, chifukwa cha chiwopsezo chomwe chimayamba chifukwa chodwala. Pambuyo pa zaka 45, chithandizo chimayamba ndi Mlingo wochepa, ndipo ngati ndi kotheka, kuwonjezereka kumafunikira kuwunika momwe wodwalayo alili.

Pa nthawi yoyembekezera, kugwiritsa ntchito mankhwalawa ndizoletsedwa, chifukwa magawo omwe amagwira ntchito amathandizira kuphwanya kukhazikika kwathunthu kwa mwana wosabadwayo.Izi zimawonjezera ngozi za kubadwa kwa ma pathologies, komanso kusokonezeka poyambira.

Mankhwala otsatirawa ndi ofanana mu mawonekedwe ndi achire:

Kusankhidwa kwa chida chimodzi kapena china chomwe chitha kuchepetsa shuga m'magazi zimatengera kuchuluka kwa matenda ashuga komanso matenda ena okhudzana nawo. Ndi dokotala yekha amene ali ndi ufulu wakuvomereza mankhwala, ndikusankha mulingo woyenera kwambiri mwanjira ina. Kudzichiritsa nokha kuli kowopsa pakukula kwa matenda ashuga komanso zina zosasangalatsa pamoyo.