Mefarmil: Malangizo ntchito > Chithandizo ndi kupewa

Mankhwala ndi a gulu la Biguanides, yogwira mankhwala ndi dimethyl biguanide. Pezani izi kuchokera ku chomera Galega officinalis. Metformin imasokoneza kapangidwe ka shuga ndi chiwindi (njira ya shuga), potero kuchepetsa magazi. Mothandizirana ndi izi, mankhwalawa amawonjezera chidwi cha insulin receptors, kusintha mayamwidwe, amalimbikitsa makutidwe ndi okosijeni a mafuta, kumawonjezera kugwiritsidwa ntchito kwa glucose, ndikuchepetsa mayamwidwe ake kuchokera kumimba.

Chidacho chimathandiza kuchepetsa chithokomiro chithokomiro cha chithokomiro mu seramu yamagazi, kutsitsa cholesterol ndi lipoprotein yotsika, potero kupewa ma pathological m'mitsempha yamagazi. Matendawa amagwirizananso ndimagazi, kukonza ziphuphu zake, potero amathandizira kuchepetsa chiopsezo cha thrombosis.

Ndemanga za Endocrinologists za Metformin zimatsimikizira chidziwitso kuti zimathandizira kuchepetsa kunenepa kwambiri.

Ma Analogs a Metformin

Ma analogu a Metformin akuphatikizapo mankhwala otsatirawa: Glucofage, Metformin-BMS, Metformin hydrochloride, Metformin-vero, Metformin-Richter, Formmetin, Fomu Pliv, Glformin, Glucofag, Vero-Metformin Novoformin, Metospanin. Metfogamma, Siofor, Glycomet, Dianormet, Orabet, Bagomet, Gliminfor, Glycon.

Kuchokera pamawonedwe a pharmacological, analog ya Metformin ndi insulin.

Zizindikiro zogwiritsidwa ntchito

Kugwiritsidwa ntchito kwa Metformin kukuwonetsedwa pochiza matenda amishuga amtundu wa 2 omwe ali ndi vuto laimpso, komanso boma. Chizindikiro chowoneka chogwiritsidwa ntchito ndi mtundu wa 2 shuga, limodzi ndi kunenepa kwambiri.

Amagwiritsidwanso ntchito ngati gawo la zovuta kuchiza matenda am'mimba-visceral kunenepa.

Nthawi yomwe amagwiritsidwa ntchito pazachipatala, kuwunika kwa Metformin kunali kwabwino kwambiri kotero kuti atayesa mayeso azachipatala omwe adawatsimikizira, mu 2007 mankhwalawa adalimbikitsidwa kuti agwiritsidwe ntchito pochita zochizira matenda a matenda ashuga a mtundu woyamba, monga cholowa pakuchiritsa matenda a insulin.

Malangizo ogwiritsira ntchito Metformin

Mapiritsi a Metformin amatengedwa mosamalitsa kudya, kumwa madzi ambiri. Mlingo woyamba komanso woyamba ndi 1000 mg patsiku, mlingo umakulirakudya kupitilira masabata 1-2, kufunikira kwake kumasinthika motsogozedwa ndi data ya labotale pamlingo wa shuga m'magazi. Mlingo wovomerezeka waukulu ndi 3000 mg patsiku. Mlingo wa tsiku ndi tsiku utha kugwiritsidwa ntchito nthawi imodzi, koma kumayambiriro kwa chithandizo chamankhwala, pakusintha kwazinthu, tikulimbikitsidwa kuti muugawe mu 2-3 Mlingo, womwe umathandizira kuchepetsa zotsatira zoyipa za mankhwala pamimba.

Kupezeka kwakukulu kwa mankhwalawa m'madzi am'magazi kumachitika pakatha maola awiri pambuyo pa utsogoleri, pambuyo pa maola 6 akuyamba kutsika. Pambuyo masiku awiri akumwa pafupipafupi, kuphatikizira kwa mankhwalawo m'magazi kumakhazikitsidwa, malinga ndi ndemanga, Metformin imayamba kukhala ndi zotsatira zowonekera masabata awiri pambuyo poyambira kutsata.

Ndi kuphatikiza kwa Metformin ndi insulin, kuyang'aniridwa kwachipatala ndikofunikira, ndi milingo yayikulu ya insulin kuchipatala.

Zotsatira zoyipa

Ikagwiritsidwa ntchito molingana ndi malangizo, Metformin nthawi zambiri imavomerezedwa ndi odwala, kawirikawiri sizoyambitsa mavuto. Ngati pali chilichonse, ndiye, monga lamulo, zimagwirizanitsidwa ndi kusalolera payekha kwa mankhwalawo, kapena mogwirizana ndi mankhwala ena, kapena ndi kuchuluka kwa mankhwala.

Malinga ndi ndemanga, Metformin nthawi zambiri imayambitsa matenda am'mimba, omwe amawonetsedwa mu mawonekedwe a dyspepsia mu mawonekedwe amtundu wina, monga chimodzi mwazizindikiro za lactic acidosis. Nthawi zambiri, zizindikiro zotere zimawonedwa kumayambiriro kwa chithandizo cha mankhwalawa, ndipo patapita nthawi yochepa. Malinga ndi malangizo, Metformin panthawiyi iyenera kugwiritsidwa ntchito muyezo wochepetsedwa, ndi lactic acidosis yayikulu, mankhwalawo adatha.

Pogwiritsa ntchito nthawi yayitali, Metformin imathandizira kusokoneza kusinthana kwa vitamini B12 (cyancobalamin), kuletsa kuyamwa kwake m'matumbo, zomwe zimatha kuyambitsa kuchepa kwa magazi m'thupi mwa B12. Vutoli limafunikira kukonzedwa kwa mankhwala.

Contraindication Metformin

Zotsutsana zotsatirazi zikuwonetsedwa mu malangizo a Metformin:

Zamakono kapena zam'mbuyomu lactic acidosis
Mkhalidwe wokongola
Hypersensitivity pazinthu zilizonse za mankhwala,
Matenda a impso, komanso matenda opatsirana omwe angayambitse kuphwanya,
Kulephera kwa adrenal,
Kulephera kwa chiwindi
Matenda a shuga
Zinthu zonse zomwe zimayambitsa matenda am'madzi (kusanza, kutsegula m'mimba) ndi hypoxia (kugwedezeka, kulephera kwa mtima),
Mowa Tiyenera kukumbukira kuti ngakhale kugwiritsidwa ntchito limodzi kwa Metformin ndi mowa kumatha kuyambitsa zovuta za metabolic,
Matenda opatsirana nthawi yovuta kwambiri, limodzi ndi kutentha,
Matenda opatsirana pakufika pobweza,
Opaleshoni yayikulu ndi kukonza ntchito pambuyo,
Kuyamwitsa

Mimba, monga ubwana, siziwonedwanso kuti ndi contraindication wothira kumwa mankhwalawa, popeza ndizotheka kupereka Metformin pochiza matenda a gestational ndi achinyamata, komabe, muzochitika izi, chithandizo chimachitika mosamalitsa pazoyang'anira zamankhwala.

Malangizo apadera

Ndi Metformin monotherapy, palibe chiopsezo chokhala ndi hypoglycemia, chiwopsezo chotere sichimaphatikizidwa mu chithandizo chovuta cha matenda a shuga, ndipo wodwalayo ayenera kuchenjezedwa za izi. Kugwiritsa ntchito limodzi kwa mankhwalawa ndi intravascular radiopaque yomwe ili ndi ayodini sikuletsedwa. Kugwiritsa ntchito kulikonse kwa Metformin ndi mankhwala ena kumafuna kuyang'aniridwa ndi dokotala. Pakupanga opaleshoni, mankhwala othandizira amathetsedwa kwa masiku atatu a pambuyo pa ntchito. Malangizo a Metformin amafotokozera zakudya nthawi yonse ya mankhwalawa, yomwe imapewa nsonga zakuthwa ndikutsikira m'magazi a magazi, zomwe zimapangitsa kuchepa kwa thanzi.