Trazhenta mankhwala: malangizo, ndemanga ya odwala matenda ashuga ndi mtengo

Mankhwalawa amapangidwa mwanjira ya mapiritsi ozungulira a mtundu wofiira wowala. Iliyonse yomwe yasanjikizidwa m'mbali komanso mbali ziwiri zakumaso, pomwe chimodzi chimayikidwa chizindikiro, pomwe inayo pali cholembedwa "D5".

Monga tafotokozera m'malamulo opita ku Trazhent, gawo lalikulu la piritsi limodzi ndi lignagliptin ndi voliyumu ya 5 mg. Zinthu zina zimaphatikizapo wowuma chimanga (18 mg), Copovidone (5.4 mg), mannitol (130.9 mg), wowuma wa pregelatinized (18 mg), magnesium stearate (2.7 mg). Kuphatikizika kwa chipolalachi kumaphatikizapo pink opadra (02F34337) 5 mg.

Mutha kugula Trazhenta mu matuza a aluminium (mu mapiritsi 7). Kuti mugwiritse ntchito, ali pakatakata, komwe mungapeze matuza 2, 4 kapena 8. Chithuza chimodzi chimatha kugwiranso mapiritsi 10 (pamenepa, zidutswa zitatu paphukusi).

Trazhenty

Chofunikira chachikulu cha Trazhenta ndi cholepheretsa cha enzyme dipeptidyl peptidase-4 (DPP-4), chomwe chimawononga mwachangu mahomoni a insretin (GLP-1 ndi HIP) ofunikira kuti thupi laumunthu likhale ndi shuga wabwinobwino mkati mwake. Kuzungulira kwa mahomoni awiriwa kumachuluka mukangodya. Ngati magazi abwinobwino kapena okwera pang'ono m'magazi alipo m'magazi, ndiye kuti GLP-1 ndi HIP imathandizira biosynthesis ya insulin, komanso kapangidwe kake ndi kapamba. GLP-1 imathandizanso kuchepetsa kupanga shuga mu chiwindi.

Analogs a Trazhenta ndi mankhwalawo pawokha amawonjezera kuchuluka kwa ma protein chifukwa cha zomwe amachita ndipo, kuwalimbikitsa, kuwakakamiza kuti azigwirabe ntchito yawo kwa nthawi yayitali. Potsatira ndemanga ya Trazhent, zidadziwika kuti mankhwalawa amathandizira kuti shuga iwonjezeke ndi shuga komanso amachepetsa katulutsidwe ka glucagon, motero amakhala ndi shuga m'magazi.

Zizindikiro zogwiritsidwa ntchito

Mu ndemanga ya Trazhent, akuti mankhwala awa amaperekedwa kwa odwala omwe ali ndi mtundu II matenda a shuga, komanso:

• Perekani ngati mankhwala amodzi kwa odwala omwe ali ndi vuto lalikulu la glycemic, omwe amachitika chifukwa cha zakudya kapena masewera olimbitsa thupi.
• Mopanda tsankho kwa metformin kapena ngati wodwalayo akuvutika ndi impso ndipo ndi zoletsedwa kutenga metformin.
• Itha kugwiritsidwa ntchito limodzi ndi metformin, sulfonylurea zotumphukira kapena thiazolidinedione pamene chithandizo ndi zakudya, monotherapy ndi mankhwalawa, komanso masewera sizinapereke zotsatira zomwe mukufuna.

Kodi mankhwalawa amagwira ntchito bwanji?

Ma mahomoni amtundu wa incretin amathandizira mwachindunji kuchepetsa glucose kukhala gawo lanyama. Kuphatikizika kwawo kumawonjezeka poyankha kulowa kwa glucose m'matumbo. Zotsatira za ntchito ya ma insretins ndikuwonjezereka kwa kapangidwe ka insulin, kuchepa kwa glucagon, komwe kumayambitsa kugwa kwa glycemia.

Ma incretins amawonongeka mwachangu ndi ma enzymes apadera DPP-4. Mankhwala Trazhenta amatha kumangiriza ma enzyme awa, amachepetsa ntchito, chifukwa chake, amakhalanso ndi moyo wa ma insretin ndikuwonjezera kutulutsidwa kwa insulin m'magazi a shuga.

Ubwino wosakayika wa Trazhenta ndikuchotsa chinthu chomwe chimagwira makamaka ndi bile kudzera m'matumbo. Malinga ndi malangizo, osapitilira 5% ya linagliptin amalowa mkodzo, amachepetsa kwambiri mu chiwindi.

Malinga ndi anthu odwala matenda ashuga, zabwino za Trazhenty ndi:

• kumwa mankhwalawa kamodzi patsiku,
• odwala onse amupatsa mlingo umodzi,
• kusintha kwa mankhwala sikofunikira pa matenda a chiwindi ndi impso,
• palibe mayeso owonjezera omwe amafunika kusankha Trazhents,
• mankhwalawa alibe poizoni,
• Mlingo sasintha mutamwa Trazhenty ndi mankhwala ena,
• mogwirizana ndi mankhwala a linagliptin pafupifupi sikuchepetsa mphamvu yake. Kwa odwala matenda ashuga, izi ndi zowona, chifukwa amayenera kumwa mankhwalawa nthawi imodzi.

Mlingo ndi mawonekedwe

Trazhenta wa mankhwalawa amapezeka mu mawonekedwe a mapiritsi mu mtundu wofiyira. Kuti mudziteteze pamabodza, chinthu chomwe chimapanga malonda a Beringer Ingelheim Gulu la Makampani, chimakankhidwa mbali imodzi, ndipo zizindikiro za D5 zimakanikizidwa mbali inayo.

Piritsi ili mu chipolopolo cha filimu, magawo ake samaperekedwa. Phukusi lomwe linagulitsidwa ku Russia, mapiritsi 30 (matuza atatu a ma PC 10.). Piritsi lililonse la Trazhenta limakhala ndi 5 mg linagliptin, wowuma, mannitol, magnesium stearate, utoto. Malangizo ogwiritsira ntchito amapereka mndandanda wathunthu wazinthu zothandizira.

Malangizo ogwiritsira ntchito

Pankhani ya matenda a shuga a shuga, mlingo woyenera watsiku ndi tsiku ndi piritsi limodzi. Mutha kumwa nthawi iliyonse yabwino, osagwirizana ndi zakudya. Ngati mankhwalawa a Trezhent adalembedwa kuwonjezera pa metformin, mlingo wake umasinthidwa.

Mukasowa piritsi, mutha kumwa tsiku lomwelo. Kumwa Trazhent muyezo wapawiri ndizoletsedwa, ngakhale kulandilidwa kunakusowa tsiku lakale.

Mukagwiritsidwa ntchito limodzi ndi glimepiride, glibenclamide, gliclazide ndi analogues, hypoglycemia ndiyotheka. Kuti mupewe, Trazhenta aledzera monga kale, ndipo mlingo wa mankhwala ena umachepetsedwa kufikira standardoglycemia itakwaniritsidwa. Pakupita masiku atatu kuchokera pamene anayamba kumwa Trazhenta, kuchuluka kwa shuga kumafunika, chifukwa mphamvu ya mankhwalawa imayamba pang'onopang'ono. Malinga ndi ndemanga, mutasankha mtundu watsopano, pafupipafupi komanso kuopsa kwa hypoglycemia kumakhala kocheperapo kuposa chithandizo cha Trazhenta.

Mankhwala omwe mungathe kuchita mogwirizana ndi malangizo:

Mankhwala ena, kuyanjana ndi Trazhenta sikunapezeke.

Zomwe zitha kuvulaza

Zotsatira zoyipa zomwe zimachitika Trazenti adayang'aniridwa panthawi ya mayesero azachipatala komanso atagulitsa mankhwalawo. Malinga ndi zotsatira zawo, Trazhenta anali m'modzi wa otetezeka kwambiri a hypoglycemic. Kuopsa kwa zovuta zomwe zimakhudzana ndikumwa mapiritsi sikochepa.

Chosangalatsa ndichakuti pagulu la odwala matenda ashuga omwe adalandira placebo (mapiritsi osagwira ntchito iliyonse), 4,3% adakana kulandira chithandizo, chifukwa chake panali zotsatirapo zoyipa. Mu gulu lomwe limatenga Trazhent, odwala awa anali ocheperako, 3,4%.

Mu malangizo ogwiritsira ntchito, mavuto onse azaumoyo omwe amakumana ndi odwala matenda ashuga panthawi ya kafukufuku amatengedwa patebulo lalikulu. Pano, komanso matenda opatsirana, ndi mavairasi, komanso matenda a parasitic. Ndi kuthekera kwakukulu Trazenta sichomwe chidayambitsa kuphwanya izi. Chitetezo ndi monotherapy ya Trazhenta, komanso kuphatikiza kwake ndi othandizira odwala matenda ashuga, adayesedwa. Muzochitika zonse, palibe zotsatira zoyipa zomwe zidapezeka.

Kuchiza ndi Trazhenta ndi kotetezeka komanso pankhani ya hypoglycemia. Kafukufuku akuwonetsa kuti ngakhale odwala matenda ashuga omwe ali ndi vuto la madontho a shuga (anthu okalamba omwe ali ndi matenda a impso, kunenepa kwambiri), mafupidwe a hypoglycemia sapitilira 1%. Trazhenta siyikusokoneza ntchito ya mtima ndi mitsempha yamagazi, sikuti imabweretsa kuwonjezeka pang'onopang'ono, monga sulfonylureas.

Bongo

Mlingo umodzi wa 600 mg wa linagliptin (mapiritsi 120 a Trazhenta) amalekeredwa bwino ndipo samayambitsa mavuto azaumoyo. Zotsatira za Mlingo wapamwamba pamthupi sizinaphunzire. Kutengera ndi mawonekedwe a mankhwala osokoneza bongo, kuchotsedwa kwa mapiritsi osaphatikizika kuchokera m'matumbo am'mimba (gastric lavage) kudzakhala kuchitapo kanthu ngati munthu atamwa bongo kwambiri. Chithandizo cha zizindikiro ndi kuwunika kwa zizindikiro zofunika kumachitidwanso. Kutsegula vuto la bongo wa Trazent sikothandiza.

Doctor of Medical Science, Mutu wa Institute of Diabetesology - Tatyana Yakovleva

Ndakhala ndikuphunzira matenda a shuga kwa zaka zambiri. Zimakhala zowopsa anthu ambiri akamwalira, ndipo makamaka amakhala olumala chifukwa cha matenda ashuga.

Ndithamangira kunena mbiri yabwino - Endocrinological Research Center ya Russia Academy of Medical Science idatha kupanga mankhwala omwe amachiritsiratu matenda ashuga. Pakadali pano, kugwiritsa ntchito bwino kwa mankhwalawa kuyandikira 98%.

Nkhani ina yabwino: Unduna wa Zaumoyo wateteza kukhazikitsidwa kwa pulogalamu yapadera yomwe imalipira mtengo wa mankhwalawo. Ku Russia, odwala matenda ashuga mpaka Meyi 18 (kuphatikiza) nditha kuipeza - Kwa ma ruble 147 okha!

Contraindication

Mapiritsi osamala sagwirira ntchito:

1. Ngati wodwalayo alibe maselo a beta omwe amatha kupanga insulin. Choyambitsa chimatha kukhala matenda a shuga 1 kapena pancreatic resection.
2. Ngati mumadwala zilizonse zomwe zimapanga piritsi.
3. Mu pachimake hyperglycemic mavuto a shuga. Chithandizo chovomerezeka cha ketoacidosis ndi insulin ya insulin kuti muchepetse glycemia ndi saline kuti athetse kusowa kwamadzi. Mapiritsi aliwonse amakonzedwa amathetsedwa mpaka mkhalidwewo ukhazikika.
4. Ndi kuyamwitsa. Linagliptin imatha kulowa mkaka, m'mimba mwa mwana, imakhudza kagayidwe kake ka chakudya.
5. Pa nthawi yoyembekezera. Palibe umboni wonena za kuthekera kwa linagliptin kulowetsedwa mwa placenta.
6. Pa odwala matenda ashuga osakwana zaka 18. Zokhudza thupi la ana sizinaphunzire.

Pokhapokha pakuwonetsetsa chidwi ndi thanzi, Trazhent amaloledwa kusankha odwala omwe ali ndi zaka zopitilira 80, omwe ali ndi pancreatitis yovuta komanso yopweteka. Gwiritsani ntchito molumikizana ndi insulin komanso sulfonylurea kumafuna kuwongolera shuga, chifukwa zingayambitse hypoglycemia.

Zomwe analogues zitha kusintha

Trazhenta ndi mankhwala atsopano, chitetezo cha patent chikugwirabe ntchito polimbana ndi izi, chifukwa chake ndizoletsedwa kupanga analogues ku Russia ndi mawonekedwe omwewo. Pankhani ya magwiridwe antchito, chitetezo ndi magwiridwe antchito, magulu ofananirawa ali pafupi kwambiri ndi Trazent - DPP4 inhibitors, kapena glisitins. Zinthu zonse zomwe zimachokera pagululi zimatchedwa kutha ndi -gliptin, kotero zimatha kusiyanitsidwa ndi mapiritsi ena ambiri odwala matenda ashuga.

Zofanana poyerekeza ndi ma glissins:

(sizofunika)

(chofunikira)

Kukonzekera kwa Sulfonylurea (PSM) ndi njira zotsika mtengo za Trazhenta. Zimathandizanso kaphatikizidwe ka insulin, koma kapangidwe ka kayendedwe ka maselo ka beta kamasiyana. Trazenta amagwira ntchito atatha kudya. PSM imalimbikitsa kutulutsidwa kwa insulini, ngakhale shuga m'magazi ndikwabwinobwino, chifukwa chake nthawi zambiri amayambitsa hypoglycemia. Pali umboni kuti PSM imasokoneza bwino boma la maselo a beta. Mankhwala Trazhenta pankhaniyi ndi otetezeka.

PSM yamakono komanso yopanda vuto lililonse ndi glimepiride (Amaryl, Diameride) komanso glycazide (Diabeteson), Glidiab ndi ma analogu ena). Ubwino wa mankhwalawa ndi mtengo wotsika, mwezi woyendetsera ndalama umakhala ndi ma ruble a 150-350.

Malamulo osungira ndi mtengo

Kuyika Trazhenty kumawononga ma ruble 1600-1950. Mutha kugula kokha ndi mankhwala. Linagliptin imaphatikizidwa mndandanda wazamankhwala ofunikira (Vital and Essential Diction), ngati pali zisonyezo, odwala matenda ashuga omwe adalembetsedwa ndi endocrinologist atha kumalandira.

Tsiku lotha ntchito kwa Trazenti ndi zaka 3, kutentha m'malo osungirako sikuyenera kupitirira 25 digiri.

Onetsetsani kuti mwaphunzira! Kodi mukuganiza kuti kuyamwa kwa mapiritsi ndi insulini kwa nthawi yonse yokhayo ndi njira yokhayo yosungira shuga m'manja? Sichowona! Mutha kutsimikizira izi nokha ndikuyamba kuzigwiritsa ntchito. werengani zambiri >>

Trazhenta mankhwala: malangizo, ndemanga ya odwala matenda ashuga ndi mtengo

Trazhenta ndi mankhwala atsopano kuti achepetse shuga m'magazi a shuga, ku Russia adalembedwa mu 2012. Chosakaniza chogwira cha Trazhenta, linagliptin, ndi imodzi mwamagulu otetezeka kwambiri othandizira a hypoglycemic - DPP-4 inhibitors. Amalekeredwa bwino, alibe zotsatira zoyipa, ndipo samayambitsa hypoglycemia.

Trazenta pagulu la mankhwala omwe ali ndi pafupi amayima padera. Linagliptin amagwira ntchito kwambiri, motero piritsi lokha 5 mg yokha. Kuphatikiza apo, impso ndi chiwindi sizitenga nawo gawo pazakudya zake, zomwe zikutanthauza kuti odwala matenda ashuga omwe ali osakwanira ziwalozi amatha kutenga Trazhentu.

Malangizowo amalola kuti Trazent akhazikitsidwe kokha kwa odwala matenda ashuga omwe ali ndi matenda a 2. Monga lamulo, ndi mankhwala a mzere wa 2, ndiye kuti, amalowetsedwa mu njira ya chithandizo mukamapangira zakudya, kuchita masewera olimbitsa thupi, metformin pakulondola kapena mulingo wokwanira kusiya kuperekera chindalama chokwanira cha matenda ashuga.

Chizindikiro chovomerezeka:

1. Trazhent itha kufotokozedwa ngati hypoglycemic yokhayo ngati metformin silivomerezedwa bwino kapena kugwiritsidwa ntchito kwake ndikotsutsana.
2. Itha kugwiritsidwa ntchito ngati gawo lachithandizo chokwanira ndi mankhwala a sulfonylurea, metformin, glitazones, insulin.
3. Chiwopsezo cha hypoglycemia mukamagwiritsa ntchito Trazhenta ndi chocheperako, chifukwa chake, mankhwalawa amakonda kuti odwala omwe amakonda kutsika ndi shuga.
4. Chimodzi mwazinthu zoyipa kwambiri komanso zovuta zomwe zimachitika chifukwa cha matenda ashuga zimayambitsa matenda aimpso - nephropathy yokhala ndi kulephera kwa aimpso. Kufika pamlingo wina, izi zimachitika mu 40% ya anthu odwala matenda ashuga, nthawi zambiri amayamba asymptomatic. Kuchulukana kwa zovuta kumafunika kukonza njira yochiritsira, popeza mankhwala ambiri amatsitsidwa ndi impso. Odwala ayenera kuletsa metformin ndi vildagliptin, kuchepetsa kuchuluka kwa acarbose, sulfonylurea, saxagliptin, sitagliptin. Pomwe madokotala amatulutsa ndi glitazones, glinids ndi Trazhenta zokha.
5. Pafupipafupi pakati pa odwala matenda a shuga komanso kuwonongeka kwa chiwindi, makamaka mafuta a hepatosis. Pankhaniyi, Trazhenta ndiye mankhwala okhawo ochokera ku DPP4 inhibitors, omwe malangizowo amalola kugwiritsa ntchito popanda zoletsa. Izi ndizowona makamaka kwa odwala okalamba omwe ali pachiwopsezo cha hypoglycemia.

Kuyambira ndi Trazhenta, mutha kuyembekezera kuti hemoglobin ya glycated idzachepa pafupifupi 0.7%. Kuphatikiza ndi metformin, zotsatira zake zimakhala bwino - pafupifupi 0.95%.Umboni wa madotolo uwonetsa kuti mankhwalawa ndi othandizanso kwa odwala omwe ali ndi matenda a shuga okha komanso omwe ali ndi matenda opitilira zaka 5. Kafukufuku wochitidwa zaka zopitilira 2 atsimikizira kuti kuthandizira kwa mankhwala a Trazent sikuchepa pakapita nthawi.

Ma mahomoni amtundu wa incretin amathandizira mwachindunji kuchepetsa glucose kukhala gawo lanyama. Kuphatikizika kwawo kumawonjezeka poyankha kulowa kwa glucose m'matumbo. Zotsatira za ntchito ya ma insretins ndikuwonjezereka kwa kapangidwe ka insulin, kuchepa kwa glucagon, komwe kumayambitsa kugwa kwa glycemia.

Ma incretins amawonongeka mwachangu ndi ma enzymes apadera DPP-4. Mankhwala Trazhenta amatha kumangiriza ma enzyme awa, amachepetsa ntchito, chifukwa chake, amakhalanso ndi moyo wa ma insretin ndikuwonjezera kutulutsidwa kwa insulin m'magazi a shuga.

Ubwino wosakayika wa Trazhenta ndikuchotsa chinthu chomwe chimagwira makamaka ndi bile kudzera m'matumbo. Malinga ndi malangizo, osapitilira 5% ya linagliptin amalowa mkodzo, amachepetsa kwambiri mu chiwindi.

Malinga ndi anthu odwala matenda ashuga, zabwino za Trazhenty ndi:

• kumwa mankhwalawa kamodzi patsiku,
• odwala onse amupatsa mlingo umodzi,
• kusintha kwa mankhwala sikofunikira pa matenda a chiwindi ndi impso,
• palibe mayeso owonjezera omwe amafunika kusankha Trazhents,
• mankhwalawa alibe poizoni,
• Mlingo sasintha mutamwa Trazhenty ndi mankhwala ena,
• mogwirizana ndi mankhwala a linagliptin pafupifupi sikuchepetsa mphamvu yake. Kwa odwala matenda ashuga, izi ndi zowona, chifukwa amayenera kumwa mankhwalawa nthawi imodzi.

Trazhenta wa mankhwalawa amapezeka mu mawonekedwe a mapiritsi mu mtundu wofiyira. Kuti mudziteteze pamabodza, chinthu chomwe chimapanga malonda a Beringer Ingelheim Gulu la Makampani, chimakankhidwa mbali imodzi, ndipo zizindikiro za D5 zimakanikizidwa mbali inayo.

Piritsi ili mu chipolopolo cha filimu, magawo ake samaperekedwa. Phukusi lomwe linagulitsidwa ku Russia, mapiritsi 30 (matuza atatu a ma PC 10.). Piritsi lililonse la Trazhenta limakhala ndi 5 mg linagliptin, wowuma, mannitol, magnesium stearate, utoto. Malangizo ogwiritsira ntchito amapereka mndandanda wathunthu wazinthu zothandizira.

Pankhani ya matenda a shuga a shuga, mlingo woyenera watsiku ndi tsiku ndi piritsi limodzi. Mutha kumwa nthawi iliyonse yabwino, osagwirizana ndi zakudya. Ngati mankhwalawa a Trezhent adalembedwa kuwonjezera pa metformin, mlingo wake umasinthidwa.

Mukasowa piritsi, mutha kumwa tsiku lomwelo. Kumwa Trazhent muyezo wapawiri ndizoletsedwa, ngakhale kulandilidwa kunakusowa tsiku lakale.

Mukagwiritsidwa ntchito limodzi ndi glimepiride, glibenclamide, gliclazide ndi analogues, hypoglycemia ndiyotheka. Kuti mupewe, Trazhenta aledzera monga kale, ndipo mlingo wa mankhwala ena umachepetsedwa kufikira standardoglycemia itakwaniritsidwa. Pakupita masiku atatu kuchokera pamene anayamba kumwa Trazhenta, kuchuluka kwa shuga kumafunika, chifukwa mphamvu ya mankhwalawa imayamba pang'onopang'ono. Malinga ndi ndemanga, mutasankha mtundu watsopano, pafupipafupi komanso kuopsa kwa hypoglycemia kumakhala kocheperapo kuposa chithandizo cha Trazhenta.

Mankhwala

Mankhwala ochepetsa shuga omwe cholinga chake ndi pakamwa. Ndi cholepheretsa enzyme DPP-4, yomwe imalowetsa mahomoni a insretin GLP-1 ndi HIP, omwe akuphatikizidwa ndi kayendedwe ka kagayidwe kazachilengedwe: kuwonjezera katulutsidwe insulinm'munsi glycemiapondani katundu glucagon. Kuchita kwa mahomoniwa ndi kwakanthawi, chifukwa kumawawonongetsa ndi ma enzyme. Linagliptinimasinthira kumvero kwa DPP-4, yomwe imaphatikizapo kusungidwa kwanthaŵi yayitali kwa zochitika za insretin komanso kuwonjezeka kwa milingo yawo. Kugwiritsa ntchito kwake mtundu II matenda ashuga kumabweretsa kuchepa kwa glycosylated hemoglobin shuga mu kusala magazi ndi pambuyo chakudya pambuyo 2 maola.

Mukamatenga Metformin pali kusintha kwa magawo a glycemic, pomwe kulemera kwa thupi sikusintha. Kuphatikiza ndi zotumphukira sulfonylureasamachepetsa kwambiri glycosylated hemoglobin.

Chithandizo lignagliptin sichikula mtima (myocardial infaration, imfa yamtima).

Pharmacokinetics

Mukamamwa pakamwa, imatengedwa mwachangu ndipo Cmax imatsimikizika pambuyo pa maola 1.5. Mitsempha ya biphasic imachepa. Kudya sikukhudza pharmacokinetics. Bioavailability ndi 30%. Gawo laling'ono lamankhwala lomwe limapukusidwa. Pafupifupi 5% imachotsedwa mkodzo, ena (pafupifupi 85%) - kudzera m'matumbo. Pa mtundu uliwonse wa kulephera kwa impso, palibe chifukwa chosinthira. Komanso, kusintha kwa mlingo sikufunika pakulephera kwa chiwindi chilichonse. Maphunziro a pharmacokinetics mwa ana sanaphunzire.

Zotsatira zoyipa

Ngati mankhwalawa agwiritsidwa ntchito ngati monotherapy, samayambitsa:

Pankhani ya kuphatikiza mankhwala, hypoglycemia imadziwika. Osati - kudzimbidwa, kapamba, kutsokomola. Si kawirikawiri - angioedemanasopharyngitis urticariakunenepa hypertriglyceridemia, Hyperlipidemia.

Kuchita

Kugwiritsa ntchito nthawi imodzi Metformin, ngakhale pa mlingo wapamwamba kuposa wochiritsira, sizinayambitse kusintha kwakukulu mu pharmacokinetics ya mankhwala onse awiri.

Kugwiritsa ntchito ndi Pagogazone sizikhudza kwambiri magawo a pharmacokinetic a mankhwala onse awiriwa.

Ma pharmacokinetics a mankhwalawa sasintha akagwiritsidwa ntchito ndi Glibenclamide, koma kuchepa kwakukulu kwa Cmax kwa glibenclamide ndi 14% kwadziwika. Palibe kuyanjana kwakukulu kwachipatala ndi zotumphukira zina zomwe zikuyembekezeredwa. sulfonylureas.

Nthawi yomweyo Ritonavira kumawonjezera Cmax ya linagliptin katatu, zomwe sizofunika ndipo sizifunika kusintha kwa mlingo.

Kugwiritsa ntchito Rifampicin kumabweretsa kutsika kwa Cmax ya linagliptin, chifukwa chake, mphamvu yake yazachipatala imasungidwa, koma sikuwonekera kwathunthu.

Kugwiritsa ntchito nthawi imodzi Digoxin sizikhudza ake pharmacokinetics.

Mankhwalawa samakhudza kwambiri pharmacokinetics. Simvastatinkomabe, sikofunikira kusintha mlingo.

Linagliptin sasintha pharmacokinetics kulera kwamlomo.

Zolemba za Trazent

Mankhwala okhala ndi chinthu chomwecho - Linagliptin.

Zoterezi zimapangidwanso ndi mankhwala ochokera ku gulu lomweli. Saxagliptin, Alogliptin, Sitagliptin, Vildagliptin.

Ndemanga zowoneka

Ma Dhib-4 ma inhibitors, omwe akuphatikizira mankhwala Trazhenta, samangokhala ndi zotsatira zotsitsa shuga, komanso chitetezo chokwanira, popeza samayambitsa mikhalidwe ya hypoglycemic komanso kuwonda. Pakadali pano, gulu la mankhwalawa limadziwika kuti ndilabwino kwambiri pa matenda a shuga II.

Kuchita bwino kwambiri pama regimens osiyanasiyana othandizira kwatsimikiziridwa ndi maphunziro ambiri apadziko lonse lapansi. Ndikofunika kuwayika koyambirira kwa chithandizo CD II lembani kapena kuphatikiza ndi mankhwala ena. Amakonda kutumizidwa m'malo mothandizidwa ndi sulfonylurea mwa odwala omwe amakonda kwambiri hypoglycemic.

Pali ndemanga zomwe mankhwalawa amapangidwira monotherapy insulin kukana ndi kunenepa kwambiri. Pambuyo pa maphunziro a miyezi 3, kuchepa thupi kwambiri kunadziwika. Ndemanga zambiri zimachokera kwa odwala omwe adalandira mankhwalawa ngati gawo la zovuta mankhwala. Mothandizirana ndi izi, ndizovuta kuyesa kuchuluka ndi chitetezo cha kuchepetsa shuga, popeza mphamvu ya mankhwala ena ndi yotheka. Aliyense amadziwa zotsatira zabwino za kulemera - kuchepa kumadziwika, komwe ndikofunikira kwambiri kwa matenda ashuga.

Mankhwalawa adalembedwa kwa odwala azaka zosiyanasiyana, kuphatikizapo okalamba, komanso pamaso pa matenda a chiwindi, impso ndi matenda a mtima. Zotsatira zoyipa zomwe zimapezeka ndi mankhwalawa nasopharyngitis. Ogwiritsa ntchito amawona mtengo wokwera wa mankhwalawo, womwe umachepetsa kugwiritsa ntchito, makamaka kwaopuma.

Ntchito Trazhenty pa mimba ndi mkaka wa m`mawere

Ndi zoletsedwa kutenga Trazent ndi fanizo la Trazent panthawi yoyembekezera komanso mkaka wa m'mawere. Kafukufuku wokhudza nyama akuwonetsa kuti chinthu chachikulu chomwe chimagwiritsidwa ntchito popanga mankhwalawa chimadutsa mkaka wa m'mawere ndipo chimakhala ndi zotsatira zoyipa pakukula kwatsopano ndi moyo wa wakhanda.

Pazifukwa zofunika kwambiri kutenga linagliptin, kuyamwitsa kuyenera kuyimitsidwa.

Malangizo apadera

Matenda a trazhenta sanapatsidwe kwa anthu omwe matenda a diabetes ketoacidosis, komanso mtundu I shuga mellitus, amalembedwa. Milandu ya hypoglycemia mukamamwa Trazhenta ngati mankhwala amodzi omwe anali ofanana anali ofanana ndi omwe amapezeka chifukwa cha placebo.

Kafukufuku wazachipatala akuwonetsa kuti mwayi wokhala ndi hypoglycemia mutatha kumwa Trazhenta ndi mankhwala ena omwe samayambitsa hypoglycemia anali ofanana mutatha kugwiritsa ntchito placebo.

Zothandizira kuchokera ku sulfonylureas zimathandizira kukulitsa kwa hypoglycemia. Chifukwa chake, kuwatenga ndi linagliptin, muyenera kusamala. Nthawi zina, dokotala amatha kuchepetsa kwambiri kuchuluka kwa zotumphukira za sulfonylurea.

Mpaka pano, palibe maphunziro azachipatala omwe adalembedwa omwe anganene za kuyanjana kwa Trazhenta ndi insulin. Odwala omwe amalephera kwambiri aimpso, Trazent amaperekedwa limodzi ndi mankhwala ena a hypoglycemic.

Mafuta a shuga amapsa kwambiri ngati mumamwa Trazhenty kapena mankhwala musanadye. Chifukwa cha chizungulire pakugwiritsa ntchito mankhwalawa, ndibwino osayendetsa.

Trazenta: mitengo pamafakitale apakompyuta

Trenta 5 mg yamafuta-apiritsi 30 mg ma PC.

TRAGENT 5mg 30 ma PC. mapiritsi okhala ndi filimu

Tabu ya Trazenta. p.p.o. 5mg n30

Trenta 5 mg 30 mapiritsi

Trazhenta tbl 5mg No. 30

Zambiri zokhudzana ndi mankhwalawa ndizofanana, zimaperekedwa pazidziwitso ndipo sizilowa m'malo mwa malangizo ovomerezeka. Kudzipatsa nokha mankhwala kuopsa!

Pogwira ntchito, ubongo wathu umagwiritsa ntchito mphamvu zambiri zofanana ndi babu la 10-watt. Chifukwa chake chithunzi cha babu wapamwamba pamutu panu panthawi yomwe chikuwoneka ngati chosangalatsa sichili kutali ndi chowonadi.

Amayi ambiri amatha kusangalala mwakuganizira za thupi lawo lokongola pakalilore kuposa kugonana. Chifukwa chake, akazi, yesetsani kuyanjana.

Pakusuntha, thupi lathu limasiya kugwira ntchito. Ngakhale mtima umayima.

Chiwindi ndi chiwalo cholemera kwambiri m'thupi lathu. Kulemera kwake pafupifupi 1.5 kg.

Kuti tinene ngakhale mawu afupi komanso osavuta, timagwiritsa ntchito minofu 72.

Mankhwala ambiri poyamba anali ogulitsidwa ngati mankhwala osokoneza bongo. Mwachitsanzo, a heroin adagulitsidwa ngati mankhwala a chifuwa. Ndipo cocaine adalimbikitsidwa ndi madokotala ngati opaleshoni komanso ngati njira yowonjezerera kupirira.

Poyamba zinkakhala kuti kumatheka kumapangitsa thupi kukhala ndi mpweya wabwino. Komabe, malingaliro awa adatsutsidwa. Asayansi atsimikizira kuti ukamadzuka, munthu amazizira ubongo ndikusintha magwiridwe ake.

Mu 5% ya odwala, antidepressant clomipramine amayambitsa kuphipha.

Malinga ndi ziwerengero, Lolemba, chiopsezo cha kuvulala kwammbuyo chimawonjezeka ndi 25%, ndipo chiopsezo chogundidwa ndi mtima - ndi 33%. Samalani.

Poyesera kuti wodwalayo atuluke, madokotala nthawi zambiri amapita kutali kwambiri. Ndiye, mwachitsanzo, Charles Jensen wina mzaka kuyambira 1954 mpaka 1994. adapulumuka ntchito zopitilira 900 neoplasm.

Malinga ndi asayansi ambiri, mavitamini zovuta ndizothandiza kwa anthu.

Munthu amene amamwa mankhwala opondeleza nthawi zambiri amakhalanso ndi nkhawa. Ngati munthu athana ndi kukhumudwa paokha, ali ndi mwayi wonse wakuyiwalako zamtunduwu mpaka kalekale.

Ngati mumamwetulira kawiri kokha patsiku, mutha kutsitsa magazi ndikuchepetsa chiopsezo cha matenda a mtima ndi stroko.

Asayansi ochokera ku Yunivesite ya Oxford adachita maphunziro angapo, pomwe adazindikira kuti zamasamba zimatha kukhala zovulaza ku ubongo wa munthu, chifukwa zimapangitsa kuchepa kwa unyinji wake. Chifukwa chake, asayansi amalimbikitsa kuti asachotsere konse nsomba ndi nyama muzakudya zawo.

Pali ma syndromes osangalatsa kwambiri azachipatala, monga kuphatikiza zinthu. M'mimba mwa wodwala m'modzi wodwala mania uyu, zinthu 2500 zakunja zidapezeka.

Mafuta a nsomba akhala akudziwika kwazaka zambiri, ndipo munthawi imeneyi zatsimikiziridwa kuti zimathandizira kupewetsa kutupa, kuchepetsa ululu wolumikizana, kukonza sos.

Kodi matenda ashuga ndi chiani?

Uku ndi kuzungulira kwa dongosolo la endocrine, chifukwa chomwe kuchuluka kwa shuga m'magazi a munthuyo kumawonjezeka, chifukwa thupi limalephera kuyamwa insulin. Zotsatira za matendawa ndizovuta kwambiri - njira za metabolic zimalephera, zotengera, ziwalo ndi machitidwe amakhudzidwa. Chimodzi mwa zoopsa komanso zobisika kwambiri ndi matenda ashuga amtundu wachiwiri. Matendawa amatchedwa chiwopsezo chenicheni kwa anthu.

Mwa zina zoyambitsa kufa kwa anthu m'zaka makumi awiri zapitazi, zafika poyamba. Chomwe chimapangitsa kuti matendawa athe kutukuka amaoneka ngati kulephera kwa chitetezo chathupi. Ma antibodies amapangidwa m'thupi lomwe limawonongera maselo a pancreatic. Zotsatira zake, shuga m'magulu ambiri amayendayenda momasuka m'magazi, ndikusokoneza ziwalo ndi machitidwe. Chifukwa cha kusowa bwino, thupi limagwiritsa ntchito mafuta ngati mphamvu, zomwe zimapangitsa kuti pakhale kupangika kwa matupi a ketone, zomwe ndi zinthu zakupha. Zotsatira zake, mitundu yonse ya ma metabolic omwe amachitika mthupi amasokonezeka.

Chifukwa chake, ndikofunikira kwambiri mukapeza matenda kuti musankhe bwino mankhwalawa ndikugwiritsa ntchito mankhwala apamwamba, mwachitsanzo, "Trazhentu", kuwunika kwa madokotala ndi odwala omwe angapezeke pansipa. Kuopsa kwa matenda ashuga ndikuti kwa nthawi yayitali sikungapereke chiwonetsero chazachipatala, ndipo kuwunika kwa shuga wambiri kumapezeka mwa mwayi pakuwunika koyeserera.

Zotsatira za matenda ashuga

Asayansi kuzungulira padziko lonse lapansi akuchita kafukufuku pafupipafupi kuti adziwe njira zatsopano zopangira mankhwala omwe angagonjetse matenda oyipa. Mu 2012, mankhwala apadera adalembetsedwa m'dziko lathu, omwe samayambitsa zotsatira zoyipa komanso amavomerezedwa ndi odwala. Kuphatikiza apo, amaloledwa kuvomereza anthu omwe ali ndi impso komanso kwa chiwindi - monga momwe zalembedwera mu ndemanga ya "Trazhent".

Choopsa chachikulu ndi zovuta zotsatirazi za matenda ashuga:

• kutsika kwamawonedwe owoneka mpaka kutayika kwathunthu,
• kulephera kugwira ntchito kwa impso,
• matenda amitsempha ndi mtima - kulowetsedwa kwa myocardial, atherosulinosis, matenda a mtima a ischemic,
• Matenda a m'mapazi - purulent-necrotic process, zilonda zam'mimba,
• mawonekedwe a zilonda pamimba.
• zotupa pakhungu,
• neuropathy, yomwe imawonetsedwa ndi kupweteka, kupindika komanso kuchepa kwamphamvu kwa khungu,
• chikomokere
• kuphwanya ntchito za m'munsi.

"Trazhenta": Kufotokozera, kapangidwe

Mankhwala amapangidwa mu mawonekedwe a piritsi. Mapiritsi ozungulira a biconvex okhala ndi mbali zopindika amakhala ndi chipolopolo chofiirira. Kumbali imodzi kuli chizindikiro cha wopanga, chomwe chikuwonetsedwa ngati zolemba, mbali inayo - alphanumeric dzina lake D5.

Zomwe zimagwiritsidwa ntchito ndi linagliptin, chifukwa chogwira ntchito kwambiri pamtundu umodzi, ma milligram asanu ndi okwanira. Izi, zomwe zimapangitsa kupanga insulini, zimachepetsa kaphatikizidwe ka glucagon.Zotsatira zimachitika mphindi zana ndi makumi awiri pambuyo pa kuperekera - ndi pambuyo pa nthawi iyi kuti kuchuluka kwake kwakukulu m'magazi kumawonedwa. Omwe amafunika kupangira mapiritsi:

• magnesium wakuba,
• pregelatinized ndi wowuma chimanga,
• mannitol ndi okodzetsa,
• Copovidone ndimomwe amachokera.

Chipolopolocho chimakhala ndi hypromellose, talc, utoto wofiira (iron oxide), macrogol, titanium dioxide.

Zolemba za mankhwala

Malinga ndi madotolo, "Trazhenta" muzochita zamankhwala yatsimikizira kuti ikugwira ntchito mochiritsira mtundu wachiwiri wa matenda opatsirana a shuga mdziko la makumi asanu, kuphatikiza Russia. Kafukufuku adachitika m'maiko makumi awiri mphambu awiri momwe odwala masauzande amtundu wa shuga adagwira nawo poyesa mankhwalawa.

Chifukwa chakuti mankhwalawa amachotsedwa m'thupi la munthu kudzera m'mimba, osati kudzera mu impso, kuwonongeka mu ntchito yawo, kusintha kwa mankhwalawa sikofunikira. Uku ndikusiyana kwakukulu pakati pa Trazenti ndi othandizira ena odwala matenda ashuga. Ubwino wotsatira ndi motere: wodwalayo alibe hypoglycemia akamwa mapiritsi, onse molumikizana ndi Metformin, komanso monotherapy.

About opanga mankhwalawa

Kupanga kwa mapiritsi a Trazhenta, ndemanga zake zomwe zimapezeka mwaulere, zimachitika ndi makampani awiri azamankhwala.

1. "Eli Lilly" - kwa zaka 85 wakhala m'modzi mwa atsogoleri padziko lonse lapansi popanga zisankho zatsopano zothandiza odwala omwe adwala matenda ashuga. Kampaniyo ikukulitsa magulu ake onse pogwiritsa ntchito kafukufuku waposachedwa.
2. "Beringer Ingelheim" - imatsogolera kuyambira 1885. Amachita kafukufuku, chitukuko, kupanga, komanso kugulitsa mankhwala. Kampaniyi ndi m'modzi mwa atsogoleri makumi awiri padziko lonse lapansi omwe amagulitsa mankhwala.

Kumayambiriro kwa chaka cha 2011, makampani onsewa adasainirana mgwirizano pakulimbana ndi matenda ashuga, chifukwa cha zomwe kupita patsogolo kwakukwaniritsidwa pantchito yodwala matenda opatsirana. Cholinga cha kuyanjanaku ndikuphunzira kuphatikiza kwatsopano kwa mitundu inayi ya mankhwala omwe ali gawo la mankhwala omwe amapangidwa kuti athetse zizindikiro za matendawa.

Zotsatira zoyipa

Mankhwala ambiri omwe amagwiritsidwa ntchito pochiza matenda a shuga amatha kutsogolera m'magazi momwe kuchuluka kwa glucose m'magazi kumachepera kwambiri, komwe kumadzetsa ngozi yayikulu kwa iye. "Trazhenta", mu ndemanga pomwe amati kuti sizimayambitsa hypoglycemia, ndizosiyana ndi malamulo. Izi zimawerengedwa kuti ndi mwayi wofunika kuposa magulu ena a othandizira a hypoglycemic. Zotsatira zoyipa zomwe zimachitika munthawi ya chithandizo "Trazentoy",:

• kapamba
• kutsokomola kumachitika
• nasopharyngitis,
• Hypersensitivity
• kuchuluka kwa plasma amylase,
• zotupa
• ndi ena.

Ngati mankhwala osokoneza bongo, njira zomwe zimachitika nthawi zonse zimasonyezedwa kuti zimachotsa mankhwala osagwiritsidwa ntchito pakudya chamagaya ndi mankhwala.

"Trazhenta": ndemanga za odwala matenda ashuga ndi akatswiri azachipatala

Kuchita kwakukulu kwa mankhwalawa kwatsimikiziridwa mobwerezabwereza ndi machitidwe azachipatala ndi maphunziro apadziko lonse lapansi. Endocrinologists m'mawu awo amalimbikitsa kugwiritsa ntchito mankhwalawa pophatikizira kapena ngati chithandizo cha mzere woyamba. Ngati munthuyo ali ndi vuto la hypoglycemia, lomwe limapatsa thanzi zakudya zoyenera komanso kuchita masewera olimbitsa thupi, ndikofunika kupatsa "Trazent" m'malo mwa zotumphukira za sulfonylurea. Sizotheka nthawi zonse kuwunika momwe mankhwalawo amathandizira ngati amamwa mankhwala ophatikiza, koma ambiri zotsatira zake zimakhala zabwino, zomwe zimasonyezedwanso ndi odwala. Pali ndemanga zokhudzana ndi mankhwalawa "Trazhenta" pomwe adalimbikitsa kuti kunenepa kwambiri ndi insulin.

Ubwino wa mapiritsi odana ndi matenda ashuga ndiwakuti samathandizira kulemera, samapweteketsa chitukuko cha hypoglycemia, komanso samachulukitsa zovuta za impso. Trazhenta yawonjezera chitetezo, chofunikira kwambiri kwa odwala matenda ashuga. Chifukwa chake, pali ndemanga zabwino zambiri zokhudzana ndi chida chapaderachi. Pakati pa mphindi tawonani mtengo wokwera komanso kusalolera kwa munthu payekha.

Mankhwala a Analog "Trazhenty"

Ndemanga zomwe odwala omwe amamwa mankhwalawa amakhala nazo zimakhala zabwino. Komabe, kwa anthu ena, chifukwa cha hypersensitivity kapena tsankho, madokotala amalimbikitsa mankhwala omwewo. Izi zikuphatikiza:

• "Sitagliptin", "Januvia" - odwala amatenga mankhwalawa monga kuwonjezera pa masewera olimbitsa thupi, kudya, kukonza chiwopsezo cha glycemic, kuphatikiza apo, mankhwalawa amagwiritsidwa ntchito paliponse pochiritsa.
• "Alogliptin", "Vipidia" - nthawi zambiri mankhwalawa amalimbikitsidwa pakanapanda zotsatira za zakudya, masewera olimbitsa thupi ndi monotherapy,
• "Saksagliptin" - imapangidwa pansi pa dzina la malonda "Ongliza" pofuna kugwiritsa ntchito mtundu wachiwiri wa matenda osokoneza bongo, amagwiritsidwa ntchito ngati mankhwala a monotherapy komanso mankhwala ena apiritsi ndi inulin.

Kusankhidwa kwa analogue kumachitika kokha ndi chithandizo cha endocrinologist, kusintha kwakokha kwa mankhwala ndizoletsedwa.

Odwala omwe ali ndi vuto la impso

"Mankhwala abwino kwambiri" - mawu ngati awa amayambitsa ndemanga za "Trazhent". Kuda nkhawa kwambiri mukamamwa mankhwala othandizira odwala matenda a shuga kumakhala kumachitika ndi anthu omwe ali ndi vuto la impso, makamaka omwe akudwala hemodialysis. Kubwera kwa mankhwalawa munthaka yamapulogalamu, odwala omwe ali ndi matenda a impso adayamika, ngakhale anali okwera mtengo.

Chifukwa cha zapadera zamankhwala, shuga a m'magazi amachepetsa kwambiri pakumwa mankhwalawa kamodzi kokha patsiku pa mankhwala othandiza mamiligalamu asanu. Ndipo zilibe kanthu nthawi yakumwa mapiritsi. Mankhwalawa amalowa msanga pambuyo polowera m'matumbo am'mimba, kuchuluka kwakukulu kumayang'aniridwa pambuyo pa ola limodzi ndi theka kapena awiri atayikiridwa. Amayikamo ndowe, ndiye kuti impso ndi chiwindi sizitenga nawo mbali m'njira imeneyi.

Pomaliza

Malinga ndi ndemanga za anthu odwala matenda ashuga, Trazhent imatha kutengedwa nthawi iliyonse yabwino, mosasamala za zakudya komanso kamodzi patsiku, zomwe zimatengedwa kuti ndizophatikiza zazikulu. Chokhacho chomwe muyenera kukumbukira: simungathe kumwa kawiri tsiku limodzi. Kuphatikiza chithandizo, mlingo wa "Trazhenty" sukusintha. Kuphatikiza apo, kukonza kwake sikofunikira pa vuto ndi impso. Mapiritsiwo amalekeredwa bwino, zovuta zimachitika kawirikawiri. "Trazhenta", ndemanga zake zomwe ndizokangalika kwambiri, zili ndi chinthu chapadera chogwira ntchito kwambiri. Chosafunikira kwenikweni ndichakuti mankhwalawa amaphatikizidwa pamndandanda wazamankhwala omwe amatsalira mumafakitoreti a mankhwala aulere.

Zolemba ntchito

Trazenta ndi analogu sizigwiritsidwa ntchito pochiza matenda amtundu wa 2 wa ana. Komanso, malangizo ogwiritsira ntchito mankhwalawa amaletsa kugwiritsa ntchito mankhwalawa azimayi panthawi yobereka ndi kudyetsa mwana.

Kutengera ndi kuyesaku, opanga adawululira kulowererapo kwa chinthu chomwe chikugwira ntchito mkaka wa m'mawere, ndipo mtsogolo zitha kukhudza kukula kwa mwana wosabadwayo komanso moyo wabwinobwino wa makanda. Ngati pakufunikira kakhazikitsidwa kwa linagliptin, muyenera kusiya kaye kudyetsa kwatsopano kwa akhanda.