C-peptide ya matenda ashuga - momwe mungayesedwe ndi chifukwa

M'mabotolo osiyanasiyana, kutengera zida, mautchulidwe (miyambo yosanthula) amasiyana. Ngati mukulemba kusanthula komwe kumakhala malembedwe osiyana, ndiye kuti muyenera kuwonetsa zikhalidwe za labotale yanu.
Ngati tidalira miyambo ya in vitro (mfundo zofunika: 298-2350 pmol / l.), Ndiye 27.0 - c-peptide imachepetsedwa, motero, B-cell imatulutsa insulini yochepa kwambiri, ndikuchotsa chithandizo cha insulin.

Ngati zomwe zalembedwazi ndizosiyana (muma labotor ena, miyambo ya c-peptide ndi yosiyana kotheratu (0.53 - 2.9 ng / ml), ndiye kuti kutanthauzira kosiyanaku ndikosiyana kotheratu.

Ngati c-peptide yafupika kwenikweni poyerekeza ndi zomwe zalembedwa mu labotale yanu, ndiye kuti kupanga insulin kumachepetsedwa kwambiri. Ngati C-peptide ili mkati mwa mtundu wabwinobwino / kuchuluka pang'ono, ndiye kuti kupanga insulini kumasungidwa.

Kumbukirani: mu chithandizo cha anthu odwala matenda ashuga, chinthu chachikulu ndikuwunika mashuga am'magazi, chifukwa kubwezeretsa kwakanthawi ndi kukhalapo / kusowa kwa zovuta za shuga ndizotsatira zachindunji zamagulu a shuga m'magazi.

C-peptide - ndi chiyani?

Peptides ndi zinthu zomwe ndizomangira zotsalira zamagulu amino. Magulu osiyanasiyana a zinthuzi amakhudzidwa ndi zinthu zambiri zomwe zimachitika mthupi la munthu. C-peptide, kapena peptide yomangira, imapangidwa mu kapamba limodzi ndi insulin, chifukwa chake, ndi mulingo wazomwe zimapangidwira, munthu akhoza kuweruza kulowa kwa insulini yake yomwe m'magazi.

Insulin imapangidwa m'maselo a beta kudzera pamafotokozedwe angapo azotsatira za mankhwala. Mukakwera gawo limodzi kuti mupeze molekyu yake, tiona proinsulin. Ichi ndi zinthu zopanda ntchito zomwe zimakhala ndi insulin ndi C-peptide. Zikondazo zimatha kusunga ngati masheya, osazitaya nthawi yomweyo m'magazi. Kuti ayambe kugwira ntchito yosamutsa shuga m'maselo, ma proinsulin adagawikana ndi molekyulu ya insulin ndi C-peptide, palimodzi amakhala ofanana mumagazi ndikunyamulidwa pa mseu. Chinthu choyamba chomwe amachita ndikulowa mu chiwindi. Ndi vuto la chiwindi, insulin imatha kupangika pang'ono, koma C-peptide imadutsa momasuka, chifukwa imakhudzanso impso zokha. Chifukwa chake, kuphatikiza kwake m'magazi kumawonetsa bwino momwe kaphatikizidwe ka timadzi timene timayambira mu kapamba.

Hafu ya insulin m'magazi imasweka pambuyo mphindi 4 kuchokera kupanga, pomwe moyo wa C-peptide ndiwotalikirapo - pafupifupi mphindi 20. Kusanthula pa C-peptide kuti ayesere kugwira ntchito kwa kapamba kumakhala kolondola, popeza kusinthasintha kwake ndikocheperako. Chifukwa cha moyo wosiyana, mulingo wa C-peptide m'mwazi ndi kuchuluka kwa insulin.

Pakadutsa matenda a shuga 1 am'magazi nthawi zambiri pamakhala ma antibodies omwe amawononga insulin. Chifukwa chake, momwe zidapangidwira panthawiyi sizingatheke kuwerengeka. Koma ma antibodies awa samalabadira kwenikweni za C-peptide, chifukwa chake, kupenda kwake ndi mwayi wokhawo panthawi ino kuwunika kutayika kwa maselo a beta.

Ndikosatheka kudziwa mwachindunji kuchuluka kwa kaphatikizidwe ka mahomoni ndi kapamba ngakhale mutagwiritsa ntchito insulin, popeza mu labotale ndizosatheka kugawa insulin mu intrinsic and exo native jekeseni. Kutsimikiza kwa C-peptide pankhaniyi ndi njira yokhayo, chifukwa C-peptide sikuphatikizidwa pakukonzekera kwa insulin kwa odwala matenda a shuga.

Mpaka posachedwa, amakhulupirira kuti C-peptides sagwira ntchito kwachilengedwe. Malinga ndi kafukufuku waposachedwa, gawo lawo lachitetezo poletsa angiopathy ndi neuropathy lazindikirika. Makina a zochita za C-peptides akuphunziridwa. Ndizotheka kuti mtsogolomu zidzawonjezeredwa kukonzekera kwa insulin.

Kufunika kosanthula C-peptide

Kafukufuku wazomwe zili ndi C-peptide m'magazi nthawi zambiri amalembedwa ngati, atapanga matenda a shuga, ndizovuta kudziwa mtundu wake. Matenda a shuga amtundu woyamba amayamba chifukwa cha kuwonongeka kwa maselo a beta ndi ma antibodies, zizindikilo zoyambirira zimawoneka pomwe maselo ambiri akhudzidwa. Zotsatira zake, kuchuluka kwa insulin kumachepetsedwa kale pazomwe zimadziwika. Maselo a Beta amatha kufa pang'onopang'ono, nthawi zambiri mwa odwala aang'ono, ndipo ngati chithandizo chinayamba nthawi yomweyo. Monga lamulo, odwala omwe ali ndi zotsalira pancreatic amamva bwino, pambuyo pake amakumana ndi zovuta. Chifukwa chake, ndikofunikira kusunga maselo a beta momwe ndingathere, zomwe zimafunikira kuwunika kawirikawiri pakupanga insulin. Ndi mankhwala a insulin, izi ndizotheka pokhapokha mothandizidwa ndi C-peptide assays.

Matenda a 2 a shuga koyambirira amakhala ndi insulin yokwanira. Shuga amakwera chifukwa chakuti kugwiritsidwa ntchito kwake ndi minofu kumasokonekera. Kusanthula kwa C-peptide kumawonetsa chizolowezi kapena kuchuluka kwake, chifukwa zikondamoyo zimathandizira kutulutsidwa kwa mahomoni kuti athetse shuga wambiri. Ngakhale akupanga zochulukirapo, shuga mpaka insulin pazokwera azikhala apamwamba kuposa anthu athanzi. Popita nthawi, ndi matenda amtundu wa 2 shuga, kapamba amatuluka, kaphatikizidwe ka proinsulin kamachepa, motero C-peptide imayamba kuchepa ndipo zimayamba.

Komanso, kusanthula kumayikidwa pazifukwa zotsatirazi:

1. Pambuyo pancreatic resection, kuti mudziwe kuchuluka kwa momwe gawo latsalalo limatha kupanga, komanso ngati chithandizo cha insulin chikufunika.
2. Ngati periodic hypoglycemia imachitika, ngati matenda a shuga sawonekeranso, motero, chithandizo sichikuchitika. Ngati mankhwala ochepetsa shuga sagwiritsidwa ntchito, kuchuluka kwa glucose kumatha kutsika chifukwa chotupa chotulutsa insulini (insulinoma - werengani za izi apa http://diabetiya.ru/oslozhneniya/insulinoma.html).
3. Kuti muthane ndi kufunika kosintha kwa jakisoni wa insulini wapamwamba kwambiri wa matenda ashuga. Pakufika pamlingo wa C-peptide, munthu akhoza kuwunika kusungidwa kwa kapamba ndi kuneneratu kuwonongeka.
4. Ngati mukukayikira mawonekedwe achilendo a hypoglycemia. Anthu omwe adzipha kapena ali ndi matenda amisala amatha kupereka insulin popanda mankhwala. Kuchulukitsa kwakulu kwa mahomoni pamwamba pa C-peptide kumawonetsa kuti mahomoni adalowetsedwa.
5. Ndi matenda a chiwindi, kuyesa kuchuluka kwa kuchuluka kwa insulin mmenemo. Matenda otupa a hepatitis ndi cirrhosis amatsitsa kuchepa kwa insulin, koma sizingakhudze C-peptide.
6. Kuzindikiritsa kumayambiriro ndi nthawi yachikhululukiro cha matenda osokoneza bongo a achinyamata pamene zikondamoyo zimayamba kupanga zake zokha poyankha mankhwalawa ndi jakisoni wa insulin.
7. Ndi polycystic komanso kusabereka. Kuchulukitsa katemera wa insulini kungakhale chifukwa cha matenda amenewa, chifukwa kupanga androgens kumatheka chifukwa choyankha. Nayo, imasokoneza kukula kwa follicles ndikuletsa ovulation.

Kodi mayeso a C-peptide amaperekedwa bwanji?

Mu kapamba, kupanga kwa proinsulin kumachitika nthawi yonseyi, ndipo jakisoni wamagazi m'magazi, amathandizira kwambiri. Chifukwa chake, zotsatira zolondola, zokhazikika zimaperekedwa ndi kafukufuku pamimba yopanda kanthu. Ndikofunikira kuti kuyambira nthawi yakudya yomaliza mpaka kuthira magazi osachepera 6, maola 8 opita.

Ndikofunikira kupatula pasadakhale kukhudzidwa kwa kapamba pazinthu zomwe zimatha kupotoza kapangidwe ka insulin:

• tsiku osamwa mowa,
• siyani maphunzirowo dzulo
• Mphindi 30 musanapereke magazi, musatope thupi, yesani kuda nkhawa,
• musasute m'mawa wonse mpaka kusanthula,
• Osamamwa mankhwala. Ngati simungathe kuchita popanda iwo, kuchenjeza dokotala.

Mukadzuka komanso musanapereke magazi, madzi oyera okha ndi omwe amaloledwa popanda mpweya ndi shuga.

Magazi kuti awasanthule amatengedwa kuchokera m'mitsempha ndikupanga chubu choyesera chomwe chimakhala ndi zoteteza. Centrifuge imalekanitsa plasma ndi zinthu zamagazi, ndikugwiritsa ntchito ma reagents kudziwa kuchuluka kwa C-peptide. Kuwunikaku ndikosavuta, sikuwonjezera 2 maola. M'malo ochitira malonda, zotsatira zake zimakhala zokonzekera tsiku lotsatira.

Zizindikiro za chinthu komanso momwe zimakhudzira thupi la munthu

Mu thupi lathanzi, zochita zambiri zamagetsi zimachitika sekondi iliyonse, zomwe zimapangitsa kuti machitidwe onse azigwira ntchito mogwirizana. Selo lililonse limalumikizana mu dongosolo. Nthawi zambiri, khungu limasinthidwa nthawi zonse ndipo izi zimafunikira chida chapadera - mapuloteni. Kutsika kwamapuloteni, kumachepetsa thupi.

C peptide — mankhwalawa ndi gawo la zochitika mu kapangidwe ka insulin yachilengedwe, yomwe imatulutsa kapamba m'maselo apadera omwe amasankhidwa ndi maselo a beta. Kutanthauzira kuchokera ku chichewa chachingerezi "cholumikizira peptide", thunthu limatchedwa "kulumikiza kapena kumangiriza peptide" chifukwa limagwirizanitsa mamolekyulu ena a proinsulin wina ndi mnzake.

Kodi ndimtundu wanji womwe umafotokozedwa chifukwa cha c-peptide ndipo chifukwa chiyani ndikofunikira kwambiri ngati zili mwanjira yabwinobwino kapena ngati pali vuto?

• Mu kapamba, insulin siyisungidwa mu mawonekedwe ake oyera. Hormone losindikizidwa pachigawo choyambirira chotchedwa preproinsulin, chomwe chimaphatikiza ndi c-peptide palimodzi ndi mitundu ina ya ma peptides (A, L, B).
• Mothandizidwa ndi zinthu zapadera, peptide ya gulu la L imalekanitsidwa ndi prroinsulin ndipo pali zotsalira zotchedwa proinsulin. Koma chinthuchi sichikugwirizana ndi mahomoni omwe amawongolera shuga wamagazi.
• Nthawi zambiri, chizindikiro chikamafika kuti kuchuluka kwa shuga m'magazi, kukonzekera kwatsopano kumayamba, komwe kuchokera kumakemikolo proinsulin C peptide imalekanitsidwa. Zinthu ziwiri zimapangidwa: insulini, yopanga ma peptides A, B ndi peptide ya gulu C.

• Kudzera mu njira zapadera, zonse ziwiri (Ndi peptide ndi insulin) Lowani m'magazi ndikuyenda njira ina. Insulin imalowa m'chiwindi ndipo imadutsa gawo loyamba la kusintha. Gawo mahomoni Imadziunjikira m'chiwindi, ndipo inayo imalowa mu kayendedwe kazachilengedwe ndikusintha maselo omwe sangathe kugwira bwino ntchito popanda insulini. Nthawi zambiri, gawo la insulin ndikutembenuka kwa shuga kukhala glucose ndikuyiphatikiza mkati mwa maselo kuti ipatse maselo chakudya ndi mphamvu kwa thupi.
• C-peptide imayenda momasuka pabedi lamitsempha ndi mtsinje wamagazi. Ichita kale ntchito yake ndipo ikhoza kutayidwa kuchokera ku dongosolo. Nthawi zambiri, njira yonseyi sinatenge mphindi 20, imatayika kudzera mu impso. Kuphatikiza pa kapangidwe ka insulin, c-peptide ilibe ntchito zina ngati maselo a beta a kapamba ali munthawi yofanizira.

Pa cleavage C peptide kuchokera ku ma protein a proinsulin, kuchuluka komweko kwa protein protein c-peptide ndi insulin ya mahomoni imapangidwa. Koma, pokhala m'magazi, zinthuzi zimakhala ndi kusintha kosiyanasiyana, ndiko kuti, kuwola.

M'maphunziro a labotale, zidatsimikiziridwa kuti pansi pazovomerezeka, c-peptide imapezeka m'magazi a anthu mkati mwa mphindi 20 kuchokera pomwe imalowera m'magazi, ndipo insulini imapeza phindu pambuyo mphindi 4.

Munthawi yogwira ntchito bwino kwa thupi, zomwe zili mu c-peptide m'magazi a venous ndizokhazikika. Ngakhale insulin yomwe idalowetsedwa mthupi kuchokera kunja, kapena ma antibodies omwe amachepetsa kukana kwa maselo kupita ku mahomoni, komanso maselo a autoimmune omwe amasokoneza magwiridwe antchito a kapamba sangawakhudze.

Kutengera izi, madokotala amawunika anthu omwe ali ndi matenda ashuga kapena ali ndi vuto lakelo. Kuphatikiza apo, ma pathologies ena mu kapamba, chiwindi kapena impso amadziwika ndi c-peptide yodziwika bwino kapena mulingo wofanana.

Kuwunikira kwa c-peptide ndi chizolowezi chake pakupezeka kwa matenda ashuga m'matupi a ana asukulu zam'mbuyo komanso achinyamata ndizofunikira, chifukwa matenda amtunduwu ndiofala kwambiri chifukwa cha kunenepa kwambiri kwaubwana ndi unyamata.

Magawo osiyanasiyana a thunthu c-peptide

Kwa abambo ndi amayi palibe kusiyana makamaka malinga ndi c-peptide. Ngati thupi likugwira ntchito mokhazikika, ndiye kuti mulingo wa peptide C uyenera kufanana ndi zomwe zili pathebulopo, zomwe zimatengedwa ngati maziko a labotale:

Gome limapereka magawo osiyanasiyana a muyeso wa c-peptide, chifukwa ma labotale osiyanasiyana ophunzirira kusanthula amatenga kulemba kwawo ngati maziko.

Ana alibe chizolowezi chimodzi cha c-peptide, chifukwa mukamayesa magazi pamimba yopanda kanthu, zotsatira zake zimatha kupereka zotsatira zosapindulitsa chifukwa c-peptide imalowa m'magazi okha pamaso pa glucose. Ndipo pamimba yopanda kanthu, ngakhalenso c-peptide, kapena insulin ya m'madzi singalowe m'magazi. Poyerekeza ndi ana, adokotala okha ndi omwe amasankha kuti magawo a c-peptide ayenera kuonedwa kuti ndi abwinobwino, komanso zomwe zimayenera kutengedwa ndikupatuka kuchoka pazomwe zikuchitika.

Wodwala amatha kumvetsetsa pawokha ngati c-peptide ndiyabwinobwino, atalandira zotsatira za phunzirolo. Laborator iliyonse pa fomu imalembera malire a zomwe zili munthawi zonse. Ngati zotsatira zake ndizotsika kapena zapamwamba kuposa momwe zimakhalira p-peptide, ndiye kuti muyenera kuyang'ana zomwe zimayambitsa vuto ndikusankha momwe mungapangire, ngati zingatheke.

Kodi timadzi timeneti ndi chiyani?

C-peptide (yolumikizanso peptide) si kanthu koma mapuloteni a proinsulin, omwe amapangidwa pa kapangidwe ka insulin. Hormone iyi ikuwonetsa kupanga insulin mwachangu. Zikondazo zimapanga mahomoni angapo ofunikira m'thupi. Kuchokera m'thupi insulin imeneyi imaponyedwa m'magazi. Ndikusowa kwa timadzi timeneti, glucose sangayambe kupanga, ndichifukwa chake imadziunjikira m'thupi.

Proinsulin Cleavage Mechanism

Ngati simukuyezetsa magazi nthawi, ndiye kuti wodwala akhoza kuyamba kudwala matenda ashuga. Izi zimawonedwa mu shuga mellitus 1 digiri. Mu shuga mellitus wa digiri yachiwiri, kuyamwa kwa glucose nthawi zambiri kumalepheretsedwa ndi kunenepa kwambiri komwe kumachitika ndi metabolism woperewera. Ndipo pamenepa, glucose amadziunjikira m'magazi. Chifukwa chake, ndikofunikira kuyang'anira kuchuluka kwa shuga ndikupereka magazi pafupipafupi kuti mupeze kafukufuku.

Madokotala amakono amakonda kudziwa kuchuluka kwa C-peptide m'malo mwa insulin, chifukwa kuchuluka kwa otsika m'magazi kumakhala kotsika.

Kukhazikitsidwa kwa C-peptide limodzi ndi insulin kumachepetsa chiopsezo cha zovuta za matenda ashuga. Ngakhale timadzi timeneti sitikumvetsetsa bwino, ndizodziwika bwino kuti ndizothandiza m'thupi ndipo zimathandizira nthawi ya matenda ashuga.

Miyezi yapamwamba ikawonedwa

C-peptide imatsitsidwa kapena kuwonjezeka, kuwunikiraku kumawululira molondola, ndikuwonetsanso kuthamanga kwa mapangidwe a insulin, omwe ndiofunikira kwambiri matenda ena. Zotsatira zapamwamba ndizotheka ndi:

• matenda ashuga
• onenepa kwambiri
• oncology
• kulephera kwa aimpso
• kutenga mahomoni
• kapamba wamatumbo,
• beta cell hypertrophy.

Zomwe zimapangitsa kuti mulingo wotsika zizikhala izi:

• matenda a shuga omwe ali ndi vuto la hypoglycemic,
• mtundu 1 shuga
• kutsika kwa kuchuluka kwa shuga mthupi,
• kupsinjika

Mukayesa C peptide yoyeserera

Asanalowetsetsetsetse, simumatha kumwa zakumwa zoledzeretsa patsiku, maola 6-8 asanafike phunziroli saloledwa kudya, koma mutha kumwa madzi, muyenera kusiya kusuta ola limodzi lisanawunitsidwe. Kusanthula kwa C-peptide kumachitika motere: magazi ochokera m'mitsempha amaikidwa mu chubu chapadera ndi centrifuged.

Zotsatira za kafukufukuyu pa C-peptide zimapangitsa kuti pakhale chithandizo chokwanira kwambiri, ndikupanga mitundu ya mankhwalawa, ndikuwongolera matenda a pancreatic.

Mlingo wa C-peptide kwenikweni umagwirizana ndi mulingo wa insulin. Ndikotheka kudziwa zotsatirazi patatha maola atatu mutatha njirayi. Pambuyo popereka magazi a venous kuti muunikidwe, mutha kubwerera ku zomwe mumachita, zakudya ndi kumwa mankhwala. Mutha kuonana ndi endocrinologist pazokhudza kusanthula kwakadali ndi chithandizo china.

Kuyesedwa kwa magazi ndi komwe kumayambitsa mtundu 1 ndi mtundu wa 2 matenda a shuga, polycystic ovary syndrome, Cushing's syndrome ndi matenda ena omwe amafunikira kudziwa kuchuluka kwa timadzi tomwe timafunikira. Pamaso pa kulemera kwambiri, ludzu losatha, mkodzo wambiri, tikulimbikitsidwa kuti tichite kafukufuku pa mulingo wa C-peptide m'magazi.

Insulin ndi C-peptide zimapangidwa mu kapamba, kotero kuyezetsa magazi kwa Laborator kumaperekedwa kwa matenda amtunduwu. Mothandizidwa ndi kusanthula, magawo a chikhululukiro atsimikiza, kuti chithandizo chisinthidwe. Index ya mahomoni nthawi zambiri imachepetsedwa panthawi yowonjezera shuga.

Odwala omwe ali ndi insulinoma amatha kulumikizana kwambiri ndi peptide. Pambuyo pochotsa insulinomas, muyezo wa chinthu ichi m'thupi umasintha. Chizindikiro pamwamba pazomwe chimanenedwa chimati kubwereza kwa carcinoma kapena metastases.

Nthawi zambiri, odwala matenda ashuga amasinthana ndi insulin kuchokera pamapiritsi, kotero muyenera kuyang'anira kuchuluka kwa mahomoni mu plasma ya wodwalayo.

Zomwe zimachitika mwa akulu ndi ana

Zomwe zimachitika mwa akazi ndi abambo sizosiyana. Zomwe zimasintha sizisintha kuchokera ku msinkhu wa odwala komanso kuyambira 0.9 mpaka 7.1 ng / ml. Zizolo mu ana ndi munthu payekha ndipo zimatsimikiziridwa ndi katswiri pa milandu iliyonse. Mlingo wa chinthu ichi pamimba yopanda kanthu kuchokera pa 0.78 mpaka 1.89 ng / ml.

Zotsatira za insulin Therapy ndizochulukirapo pamlingo wa mahomoni awa. Izi zimafotokoza pancreatic reaction yachilendo pakachitika insulin yowonjezera mthupi. Nthawi zambiri, mahomoni pamimba yopanda kanthu amapitilira muyeso. Izi zikutanthauza kuti chizolowezi cha C-peptide m'magazi sichitha kuonetsa mtundu wa shuga wodwala.

Pankhaniyi, muyenera kuwonjezera kuyeserera kuti mupeze zomwe mungachite:

• kugwiritsa ntchito jakisoni wa glucagon (sikoletsedwa kwa anthu omwe ali ndi matenda oopsa kapena pheochromocytoma):
• kuyeserera kwa shuga.

Ndikofunika kudutsa mawunikidwe onsewo kuti mumve zotsatira zoyenera.

Momwe mungawerengere zotsatirazo

Kutanthauzira kwa mayeso a labotale kumagawika kukhala ndende yowonjezera ndikuchepetsedwa. Iliyonse mwa iyo imatha kuwonedwa m'matenda angapo.

• chotupa cham'mimba
• metastases kapena kuyambiranso zotupa,
• kulephera kwa aimpso
• mtundu 2 shuga
• kuchuluka kwa shuga m'magazi.

• kukhazikitsa insulin yokumba,
• lembani 1 ndikulemba matenda ashuga 2
• kupsinjika
• opaleshoni ya kapamba.

Mbali yoyamba, kukwera kwakukulu kwa chosaopsa kapena kupweteka kwapancreatic carcinoma.

Kuti muwonjezere timadzi tating'onoting'ono timene timafunikira, mufunika kubaya insulin kulowa mthupi ndi jakisoni. Izi zikuyenera kuchitika ndi matenda omwe amatsimikiziridwa molondola, chithandizo chikuyenera kuperekedwa ndi katswiri.

C-peptide: ndi chiyani

C-peptide ndi zinthu zopangidwa ndi kapamba komanso insulin. Zambiri mwa zinthuzi zimalowa m'magazi ngati insulin ya zomwe zimapanga. Kulephera sikuphatikizidwa ndi mahomoni ofunikira omwe odwala matenda ashuga amapeza kuchokera mu jakisoni kapena pampu. Kwa odwala omwe amapaka insulin, kuchuluka kwa mahomoni m'magazi kumatha kukhala kokwanira, koma C-peptide ndiyotsika.

Kuyesedwa kwa magazi kwa C-peptide ndikothandiza kwambiri pakuwunika koyambirira kwa matenda ashuga ndikuwunikanso momwe ntchito zimathandizira. Imaphatikizidwa ndi kusanthula kwa glycated hemoglobin. Koma zoyeserera zama antibodies, zomwe nthawi zambiri zimayikidwa ndi madokotala, ndizosankha. Mutha kusunga pa iwo. Mlingo wa C-peptide umawonetsa momwe kapamba amapitirizira kutulutsa insulini.

Chifukwa cha kusanthula uku, mutha kusiyanitsa pakati pa matenda ashuga amtundu wa 2 ndi mtundu 1 wa shuga, komanso kuwunika kukula kwa matendawa kwa mwana kapena wamkulu. Werengani nkhani "Kuzindikira matenda ashuga." Ngati C-peptide imagwera patapita nthawi, matendawa amapita patsogolo. Ngati sichigwa, ndipo makamaka chikukula, iyi ndiye nkhani yabwino kwa odwala matenda ashuga.

Koyeserera kwa nyama kwawonetsa kuti ndikofunikira kupangira C-peptide limodzi ndi insulin. Izi zidasintha njira ya matenda ashuga pama mbewa yoyesera. Komabe, mayesero a anthu sanabweretse zotsatirapo zabwino. Lingaliro la kubayidwa C-peptide kuwonjezera pa insulin pamapeto pake linasiyidwa mu 2014.

Momwe mungayesere magazi a C-peptide?

Monga lamulo, mayesowa amatengedwa m'mawa pamimba yopanda kanthu. Simungakhale ndi chakudya cham'mawa musanapite ku labotale, koma mungathe kumwa madzi. Namwino amatenga magazi kuchokera mu mtsempha kulowa mu chubu choyesera. Pambuyo pake, wothandizira wa labotale adzazindikira kuchuluka kwa C-peptide, komanso zizindikiro zina zomwe zingakusangalatsani inu ndi dokotala.

Nthawi zina, C-peptide sichimadziwika pamimba yopanda kanthu, koma pakuyesa kwa maola awiri shuga. Izi zimatchedwa kusanthula kwamphamvu. Izi zikutanthauza kuchuluka kwa kagayidwe ka wodwala potenga yankho la 75 ga shuga.

Kuyesedwa kwa glucose kumatenga nthawi yambiri ndipo kumayambitsa kupsinjika kwakukulu. Zimakhala zomveka kuchita izi kwa amayi apakati. Magulu ena onse a odwala amafunika kuyesedwa kuti asale kudya C-peptide ndi hemoglobin ya glycated nayo. Dokotala wanu angakupatseni mayeso ena ndi mayeso ena kuposa omwe alembedwa.

Kodi kusanthula uku ndi kuti?

M'malo azaumoyo a anthu, odwala matenda ashuga nthawi zina amapatsidwa mwayi woti ayesedwe kwaulere, kuchokera kwa endocrinologist. Kusanthula muma labotale achinsinsi kumachitika m'magulu onse a odwala, kuphatikiza opindulitsa, kwa chindapusa. Komabe, mtengo wa mayeso a magazi a C-peptide mu labotale yodziimira pawokha ndiwotsika mtengo. Phunziroli ndi la gulu la zotsika mtengo, zotsika mtengo ngakhale kwa okalamba.

M'mayiko a CIS, ma labitala achinsinsi a Captitro, Sinevo ndi ena atsegula malo ambiri komwe mungathe kubwera ndikuyesa pafupifupi mayeso opanda matepi ofiira osafunikira. Kutumiza kwa dokotala sikofunikira. Mitengo ndi yotsika, yopikisana. Ndi chimo kugwiritsa ntchito mwayiwu kwa odwala matenda ashuga komanso anthu omwe ali ndi mavuto ena azaumoyo. Nthawi ndi nthawi muziwunika kuchuluka kwa C-peptide ndi glycated hemoglobin, komanso tengani magazi ndi mkodzo mayeso omwe amawunikira ntchito ya impso.

Chikhalidwe cha C-peptide m'magazi

Chikhalidwe cha C-peptide m'magazi pamimba yopanda kanthu: 0.53 - 2.9 ng / ml. Malinga ndi zolembedwa zina, malire otsika abwinobwino ndi 0.9 ng / ml. Mukatha kudya kapena kumwa shuga, chizindikirocho chitha kupitilira mphindi 30-90 mpaka 7.0 ng / ml.

M'mabotolo ena, kusala C-peptide kumayesedwa m'magawo ena: 0.17-0.90 nanomol / lita (nmol / l).

Ndizotheka kuti mulingo wabwinobwino udzawonetsedwa pafomalo pazotsatira zomwe mumalandira. Mtunduwu umatha kusiyana ndi pamwambapa. Pankhaniyi, lingalirani.

Chikhalidwe cha C-peptide m'magazi ndichimodzimodzi kwa azimayi ndi abambo, ana, achinyamata ndi okalamba. Sizitengera zaka komanso mtundu wa odwala.

Kodi zotsatira za kuwunikaku zikuwonetsa chiyani?

Tiyeni tikambirane zakusintha kwa zotsatira za kuyezetsa magazi kwa C-peptide. Zoyenera, pomwe chizindikirocho chili pafupifupi pakati pazazolowereka. Odwala omwe ali ndi matenda a autoimmune, amachepetsa. Mwina ngakhale ziro kapena pafupi ndi zero. Mwa anthu omwe ali ndi insulin kukana, ali pamlingo wapamwamba wabwinobwino kapena wokwera.

Mulingo wa C-peptide m'magazi umawonetsa kuchuluka kwa momwe munthu amapangira insulin yake. Chizindikiro chachikulu ichi, chomwe chimagwira kwambiri ndimaselo a pancreatic beta omwe amapanga insulin. Mulingo wokwezeka wa C-peptide ndi insulin ndiye, ndi woyipa. Koma ndizovuta kwambiri pamene kupanga insulini kumachepetsedwa chifukwa cha matenda a shuga a autoimmune.

C-peptide pansipa

Ngati mwana kapena wamkulu C-peptide ali pansipa, ndiye kuti wodwalayo ali ndi matenda a shuga a autoimmune 1. Matendawa amatha kuchitika mochulukirapo kapena pang'ono. Mulimonsemo, muyenera kubaya insulin, osangotsatira chakudya! Zotsatira zake zimakhala zazikulu kwambiri ngati wodwalayo anyalanyaza jakisoni wa insulin panthawi ya chimfine ndi matenda ena opatsirana.

Izi zikugwiranso ntchito kwa anthu omwe C-peptide ili mkati mwabwinobwino, koma kufupi ndi malire ake. Izi nthawi zambiri zimachitika mwa anthu azaka zapakati ndi LADA, matenda a autoimmune a shuga omwe amakhala achikulire. Ali ndi matenda ofatsa. Zowukira za autoimmune pama cell a pancreatic beta mwina akubwera pompano. Ino ndi nthawi yoyambira matenda asanakwane shuga isanayambe.

Kodi ndizofunikira chiyani kwa anthu omwe C-peptide ili pansipa? Kwa odwala oterowo, chinthu chachikulu ndikuletsa chizindikirochi kuti chisagwere pazero kapena mfundo zosayenerera. Yesetsani kuyesetsa kuti muchepetse kugwa kapena kuti muchepetse.

Mungakwaniritse bwanji izi? Ndikofunikira kutsatira mosamalitsa zakudya zamagulu ochepa. Pewani kwathunthu zakudya zoletsedwa muzakudya zanu. Pewani mwankhanza monga momwe Ayuda ndi Asilamu achipembedzo amapewera nkhumba. Bayani jekeseni wochepa wa insulin ngati pakufunika. Izi zimakhala choncho makamaka kuzizira, poizoni wa chakudya ndi zina.

Chimachitika ndi chiani ngati C-peptide igwera mpaka zero kapena mfundo zosayenerera?

Akuluakulu ndi ana omwe magazi awo a C-peptide atsika pafupi ndi zero kungakhale kovuta kwambiri kuwongolera matenda awo a shuga. Moyo wawo umakhala wowonda kwambiri nthawi zambiri kuposa wa odwala matenda ashuga omwe adasungira mtundu wawo wa insulin. M'malo mwake, ndi matenda ashuga akulu, mutha kukhala ndi shuga wokhazikika wabwinobwino ndipo mudziteteze ku zovuta. Koma chifukwa cha izi muyenera kuwonetsa chitsulo chachitsulo, kutsatira chitsanzo cha Dr. Bernstein.

Insulin, yomwe imalowa m'thupi kuchokera ku ma syringes kapena pampu ya insulin, imachepetsa shuga m'magazi, koma siyilola kuti kudumpha kwake kupewe. Insulin yomwe, yomwe imapangidwa ndi kapamba, imakhala ngati "pushion". Imasunthira shuga m'mitsempha ndipo imathandizira kuti shuga azikhala wolimba komanso wabwinobwino. Ndipo ndicho cholinga chachikulu cha chithandizo cha matenda ashuga.

C-peptide m'chigawo chotsika bwino ndi matenda a shuga a autoimmune mwa munthu wamkulu kapena mwana. Ngati zotsatira za kusanthula zili pafupi ndi zero, ndiye kuti wodwalayo ali ndi matenda a shuga amtundu woyamba. Awa ndi matenda okhudzana, koma osiyana kwambiri m'kutu. Njira yachiwiri ndiyakulemera kakhumi kuposa yoyamba. Yesetsani kupewa kutukuka kwake, ndikupanga insulin yanu. Kuti mukwaniritse cholinga ichi, tsatirani malingaliro amatsamba lino pankhani ya zakudya ndi insulin.

Mtundu woyamba wa matenda ashuga, nthawi ya tchuthi ndi pamene mwana wodwala kapena wamkulu amadwala ndi ma insulin ochepa kapena osabayidwa konse. Ndikofunika kuti shuga amasungidwa bwino maola 24 tsiku lililonse. Pa nthawi yaukwati, C-peptide m'magazi ndi yotsika kwambiri, koma osati zero. Mwanjira ina, pali ena omwe amapanga insulin yawo. Kuyesera kusunga, mumawonjezera kukondwerera. Pali zochitika zina pomwe anthu amatha kugwiritsa ntchito nthawi yabwinoyi pazaka zambiri.

Chifukwa chiyani pali C-peptide yotsika ndi shuga wabwinobwino?

Mwina wodwalayo adadzipaka jakisoni wa insulin asanakayezetse magazi. Kapena kapamba, wogwira ntchito molimbika, adapereka kuchuluka kwa glucose panthawi yoyesedwa. Koma sizitanthauza chilichonse. Onani hemoglobin wa glycated kuti muwone ngati muli ndi matenda a shuga kapena ayi.

C-peptide yokwezeka: zikutanthauza chiyani

Nthawi zambiri, C-peptide imakwezedwa mwa odwala omwe ali ndi metabolic syndrome kapena mtundu wa 2 shuga wofatsa. Metabolic syndrome ndi kukana insulini ndi chinthu chofanana. Izi zimadziwika ndi kusazindikira bwino kwa maselo omwe akulimbana ndi insulin. Zikondamoyo zimayenera kupanga insulin yochulukirapo komanso nthawi yomweyo C-peptide. Popanda kuchuluka kwambiri pamaselo a beta, sizingatheke kukhala ndi shuga wabwinobwino.

Odwala omwe ali ndi metabolic syndrome komanso kukana insulin nthawi zambiri amakhala onenepa kwambiri. Pangakhalenso kuthamanga kwa magazi. Metabolic syndrome ndi kukana insulin ndikosavuta kuyendetsa posintha pakudya chamafuta ochepa. Amalangizidwanso kuchita maphunziro akuthupi.

Mungafunike kumwa mankhwala ambiri komanso zakudya zina zowonjezera magazi. Ngati wodwala safuna kusinthira kukhala ndi moyo wathanzi, amayembekezera kuti amwalira msana ndi vuto la mtima kapena stroke. Mwina chitukuko cha matenda ashuga amtundu 2.

Kodi C-peptide imakhala yayitali kuposa yachilendo?

Zotsatira zakuwunikaku zikuti kupanga pancreatic insulin ndi kwabwinobwino. Komabe, chidwi cha minyewa ya mahomoni awa chimachepetsedwa. Wodwala amatha kukhala ndi matenda ofatsa - metabolic syndrome. Kapena matenda oopsa kwambiri a metabolic - prediabetes, matenda a shuga a 2. Kuti mumvetse bwino za matendawo, ndibwino kuti muunikenso kafukufuku wina wa hemoglobin ya glycated.

Nthawi zina, C-peptide imakhala yotalikirapo kuposa momwe imakhalira chifukwa cha insulinoma, chotupa cha pancreatic chomwe chimakulitsa katulutsidwe wa insulin. Pakhoza kukhalabe matenda a Cushing. Nkhani ya chithandizo cha matenda osowa awa yoposa tsamba lino. Yang'anani katswiri wodziwa bwino za ma endocrinologist, ndipo kenako kambiranani naye. Ndi ma pathologies achilendo, ndizosathandiza kulumikizana ndi azachipatala, dokotala woyamba yemwe mumakumana naye.

Chifukwa chiyani C-peptide imakwezedwa komanso mulingo wa insulin m'magazi?

Zikondazo zimatulutsa C-peptide ndi insulin m'magazi nthawi yomweyo. Komabe, insulin imakhala ndi theka la moyo wa mphindi 5-6, ndipo C-peptide mpaka mphindi 30. Zikuwoneka kuti chiwindi ndi impso zidatha kale insulini, ndipo C-peptide ikupitirirabe kuzungulira mthupi.

Kuyesedwa kwa magazi kwa C-peptide pakuwonetsa matenda ashuga

Popeza thupi limapangidwa mwadongosolo, kuyesa kwa C-peptide kuli koyenera kwambiri kuzindikira matenda kuposa kuchuluka kwa insulin. Makamaka, ndi C-peptide yomwe imayesedwa kusiyanitsa mtundu 1 wa shuga ndi mtundu wachiwiri wa shuga. Magazi a insulin omwe amasinthasintha kwambiri ndipo nthawi zambiri amapereka zotsatira zosatsimikizika.

C-peptide yamtundu wa shuga

Mtundu 2 wa shuga, C-peptide imatha kukwezedwa, yabwinobwino, kapena kutsika. Otsatirawa akufotokoza zoyenera kuchita pa milandu yonseyi. Mosasamala zotsatira za mayeso anu, phunzirani njira zamomwe mungapangire odwala matenda ashuga amtundu 2. Gwiritsani ntchito kuwongolera matenda anu.

Ngati C-peptide imakwezedwa, mutha kuyesa kuti shuga yanu ikhale yabwinobwino ndi zakudya zamafuta ochepa komanso kuchita masewera olimbitsa thupi, popanda kubaya insulin. Werengani komanso nkhani ya "Mndandanda wa mapiritsi owopsa a matenda ashuga a 2." Kanani kumwa mankhwala omwe atchulidwa mmenemo.

Anthu odwala matenda ashuga omwe C-peptide ndiyabwinobwino, ndipo ngakhale pang'ono, amafunika kubaya insulin. Odwala omwe ali ndi zakudya zama carb ochepa amafunika Mlingo wocheperako wa mahomoni. Kunyalanyaza jakisoni wa insulin nthawi ya chimfine, poyizoni wazakudya ndi zina zomwe zimabweretsa zovuta.

Kodi chizindikiritso cha c-peptide ndi chiyani?

Muzochita zachipatala, kuwunika kwa c-peptide sikuti kwa odwala onse omwe abwera ku ofesi ya dokotala. Pali gulu lapadera la odwala - awa ndi amtundu wa matenda ashuga amtundu wa 2 kapena anthu omwe ali ndi zizindikiro koma samazindikira matendawa. Kutengera kuti c-peptide ndi insulin zimapangidwa ndi zikondwerero zofanana, ndipo peptide imakhalabe m'magazi motalika kuposa insulin, titha kumvetsetsa kuchokera pazomwe zilipo ngati pali kusalinganika kwazinthu zambiri za insulin.

Ngati c-peptide yapezeka m'magazi, ndiye kuti insulin yachilengedwe imapangidwanso ndi kapamba. Koma kupatuka pamachitidwe omwe amavomerezedwa nthawi zambiri kumatsimikizira matenda ena, omwe endocrinologist ayenera kudziwa. Kodi kupatuka kuzizindikiro za peptide zikuwonetsa chiyani?

Ndi kuchepa kwa mulingo wa c-peptide, titha kuganiza

• Zikondwererozi siziphatikiza insulin ya mahomoni osakwanira ndipo paliopseza kukulitsa mtundu wa matenda a shuga 1 mellitus (c-peptide ali pansipa).
• Ngati matendawa adapezeka kale, ndiye kuti kuchepa kwamphamvu kwa c-peptide kumakhala kwabwinobwino chikuwonetsa kuzimiririka kwa ntchito ya kapangidwe ka insulin zachilengedwe. Maselo a Beta amasiya kugwira ntchito ndipo amatha kuzimiriratu, ndiye kuti pali c-peptide pang'ono m'magazi.

Dotolo amasintha muyeso wa insulin yomwe wodwala matenda ashuga amalandira kuchokera kunja. Ngati mulingo wa c-peptide uli pansipa, matenda a hypoglycemia amapezeka panthawi yochiritsira (kunja) kwa mtundu wa 1 shuga mellitus insulin. Eizi zimachitika chifukwa cha mulingo woyenera wa insulin yokumba kapena panthawi yovutikira kwambiri yomwe idayambitsa kuyamwa kwa chamoyo.

Ndi kuchuluka kwa c-peptide wocheperako

Pali lingaliro kuti wodwalayo adutsa kwambiri zomwe zimakhala ndi insulin, ndiye kuti, maselo samayankha ku mahomoni awa ndipo shuga sangasinthidwe kukhala mawonekedwe abwinobwino kwa thupi. Kuperewera kwa c-peptide kukuwonetsa ma pathologies osiyanasiyana:

• Type 2 shuga (c-peptide ndiwokwera kuposa masiku).
• Hypertrophy yama cell a beta opanga insulin ndi c-peptide.
• Pancreatic chotupa (insulinoma) - pali chidziwitso chowonjezeka cha insulini, chifukwa pamakhala chida chamkati cha katulutsidwe wamkati, komwe kamayenera kutulutsa timadzi tambiri ndi c-peptide tikamayang'ana za kuchuluka kwa shuga kulowa m'magazi, osati mwachisawawa.
• Pathology ya impso, makamaka, kulephera kwawo. Nthawi zambiri, c-peptide imagwiritsidwa ntchito molondola kudzera mu impso, koma ngati sichingachite bwino m'gululi, kugwiritsidwa ntchito kwa c-peptide kumaphwanya.

Nthawi zina kuwonjezeka kwa c-peptide wachibale malinga ndi chizolowezi kumachitika chifukwa chogwiritsa ntchito mankhwala omwe amalembedwa kuti wodwala azichiza matenda ena, mwachitsanzo, matenda a shuga.

Nthawi zina kuyesedwa kwamtundu wa C-peptide kukuwonetsa

Kuyesedwa kwa magazi pazomwe zili ndi C-peptide kumayikidwa kokha ndi dokotala yemwe amayesa wodwala ndi zizindikiro za matenda ashuga.

Zifukwa zoyeserera ndi mfundo izi:

1. Kukayikira kudziwa mtundu wa matenda osokoneza bongo a shuga (c-peptide pansipa mwabwinobwino ndi mtundu 1, c-peptide kuposa yachilendo ndi mtundu 2).
2. Kodi pakufunika kusamutsira odwala matenda ashuga chifukwa cha insulin yokwanira chifukwa cha kapamba.
3. Ndi kusabereka mwa mkazi, ngati chifukwa chake ndi ovary ya polycystic.
4. Ndi insulin yosagwira insellitus (makhwala a c-peptide mwanjira iyi ali pansipa).
5. Pambuyo pakuchita opaleshoni mu kapamba chifukwa cha mapindikidwe ake kapena chotupa.
6. Ndi pafupipafupi hypoglycemia, c-peptide imayenderana ndi zomwe zimadziwika kuti zimayambitsa shuga wochepa.
7. Kulephera kwina.
8. Pozindikira matenda a chiwindi.
9. Kuwunika mkhalidwe wa mwana wosabadwayo ndi matenda a shuga. Potere, adotolo amawona ma c-peptide standard indices pawokha ndikufanizira zotsatira zake - kuchuluka kwa c-peptide kumapitilira muyeso kapena c-peptide ndiyocheperako.
10. Mwa odwala matenda ashuga omwe amamwa mowa, c-peptide nthawi zambiri imatsika kuposa masiku. Kupatuka kuzizolowereka (kuchepa) kumalembedwanso kwa odwala omwe jakisoni wa insulin amalembedwa mosalekeza.

Madandaulo a wodwalayo akumva ludzu lalikulu, kuchuluka kwambiri kwa thupi ndi kuwonjezeka kwa kuchuluka kwa mkodzo (maulendo pafupipafupi kupita kuchimbudzi) ndi chifukwa chofufuzira ngati c-peptide ndiyabwino kapena ayi. Izi ndi zizindikiro za matenda ashuga, mtundu wa omwe umatsimikiziridwa ndi chizolowezi cha peptide m'magazi.

Endocrinologist amayenera kuwunika odwala omwe apezeka ndi matenda osokoneza bongo kuti athe kuwunika momwe mankhwalawo amathandizira komanso kupewa kukula kwa mawonekedwe osakanikirana ndi insulin.

Koma zikuwoneka kuti chithandizo cha mahomoni chathandizira kukhazikitsa maselo a beta ndipo kuchuluka kwa insulin yachilengedwe kuyandikira kwabwinobwino, monga zikuwonekera ndi kuchuluka kwa c-peptide. Kenako wodwalayo ali ndi mwayi wofafaniza jakisoni wa mahomoni ndi kusinthira kuchithandizo chokha ndi zakudya.

Kodi magazi amawunika bwanji c-peptide

Zachilengedwe zomwe zimakhala ndi c-peptide m'thupi kapena ayi imatha kupezeka ndi kuyezetsa magazi kochitika pamimba yopanda kanthu m'mawa. The biomaterial amatengedwa kuchokera mu mtsempha kuti azindikire mawonekedwe kapena osakhala a c-peptide.

Chakudya chotsiriza sichikhala mochedwa kuposa maola 6-8 musanatengere biomaterial ku labotale ya c-peptide. Ngati wodwala atenga mankhwala omwe amatha kupotoza c-peptide, ngakhale ndi synthesis ya mahomoni oyenera, ndiye kuti ayenera kuchotsedwa kwa masiku 2-3 musanayesedwe kwa c-peptide.

Nthawi zina, kusanthula kwa kutsatira c-peptide ndi chizolowezi kapena kusakhazikika kwake kumagwiritsanso ntchito njira yachiwiri yoyeserera, pogwiritsa ntchito mayeso olimbikitsa. Glucagon ya mahoni imaperekedwa kwa wodwala ndipo kuyesedwa kwa glucose kumachitika..

Zotsatira zolondola kwambiri pamlingo wa c-peptide m'magazi gwiritsani ntchito njira ziwiri zodziwira matenda nthawi imodzi ndikufanizira manambala, ndikuwayerekezera ndi chikhalidwe cha c-peptide cha munthu wathanzi. Zotsatira za kusanthula kwa c-peptide ndizodziwikiratu osati kwa adokotala, komanso kwa wodwalayo, chifukwa kuchuluka kwa mitundu yachilendo ya c-peptide kwalembedwa mwanjira ya labotale iliyonse. Koma chithandizo ndi kupatuka kwa mlingo wa c-peptide kuchokera ku chizolowezi chitha kuperekedwa ndi dokotala. Kwa munthu wophweka, ngakhale c-peptide ndiyotsika poyerekeza ndi wamba kapena wapamwamba, awa ndi belu lodabwitsa, lomwe limakhala lolephera mthupi.

Zotsatira zotsatirazi zitha kupotoza zotsatira za c-peptide assay:

• Kusuta. Fodya womaliza sayenera kusuta pasanadutse maola atatu musanachotsere magazi. Kunyalanyaza malangizowo kungayambitse kuchepa kwa c-peptide, ngakhale kudzakhala kwabwinobwino.
• Mowaamachepetsa mulingo wa c-peptide. Dokotala atha kukuwuzani kuti mupeze matenda am'mimba mu kapamba, ngakhale magwiridwe ake azikhala achilendo.
• Kupsinjika kulikonse kwamthupi, kwamalingaliro musanawunikidwe, sikuti pokhapokha mtundu wa c-peptide sunatulutse mawonekedwe kukhala otsika kapena ochuluka a c-peptide ogwirizana ndi chizolowezi.

Pomaliza

Chifukwa chake, popeza ndamvetsetsa za c-peptide ndi ntchito ya c-peptide m'thupi, payenera kukhala mafunso okhudza kufunika kwa maphunziro a labotale pamlingo wa c-peptide, makamaka odwala matenda ashuga. Mlingo wa c-peptide ndikofunikira pa chithandizo chamankhwala komanso kuwunika momwe mankhwalawo alili.

Koma kuti mudziwe ngati c-peptide ndiyabwinobwino mwa mkazi kapena mwamunayo, sangakhale kokha endocrinologist, komanso akatswiri ena, ndikuwonetsa kuti wodwalayo ali ndi kuphwanya thupi.

Kodi zikutanthauza chiyani ngati C-peptide ili yabwinobwino m'matenda a shuga?

Mwambiri, mwa wodwala yemwe ali ndi matenda a shuga a 2, C-peptide idakwezedwa kale. Komabe, kuukira kwa autoimmune kumawononga pang'ono ndi pang'ono ma cell a pancreatic beta. Kunenepa kwambiri kwasanduka shuga. Izi zikutanthauza kuti kuukira kwa autoimmune paz kapamba kukubwera. Amachitika ndi mafunde kapena mosalekeza.

Chifukwa cha iwo, kupanga insulin ndipo nthawi yomweyo C-peptide imachepetsedwa. Pakadali pano, watsika kuchoka pamwambamwamba kukhala wabwinobwino. Matendawa akapita patsogolo, kuchuluka kwa C-peptide pakapita nthawi kudzakhala kocheperako. Chifukwa chakuchepa kwa insulin, shuga ya magazi idzachuluka.

C-peptide ndiyachilendo kapena yotsika - izi zikutanthauza kuti muyenera kupatsa jakisoni wa insulin momwe amafunikira, osangotsatira zakudya zamafuta ochepa. Zachidziwikire, ngati mukufunitsitsa kudziteteza ku zovuta za matenda ashuga, kukhala ndi moyo wautali komanso wopanda chilema. Apanso, kuyezetsa magazi kwa glycated hemoglobin kumakwaniritsa C-peptide pakuwunikira bwino momwe amathandizira odwala matenda a shuga.

Ndemanga 16 pa "C-peptide"

Moni Sergey! Mwana wamkazi ali ndi zaka 12, mwana wamwamuna ali ndi zaka 7. Adayesedwa mu labotale yolipira, mwana wamkazi anali ndi c-peptide 280 (malire otsika ndi 260), mwana wamwamuna anali ndi 262. hemoglobin ya glycated mwa mwana wamkazi inali 5.3% mu Januware ndi 5.5% mu Juni. Mwana wanga wamwamuna anali ndi 5.2% mu Januware ndi 5.4% mu Juni. Kunyumba ndimawaunikira shuga nthawi ndi nthawi ndi glucometer ya Sattelit, chifukwa ndi okhawo amene ali ndi magazi athunthu. Nthawi zina ndimawona shuga wowonjezereka mwa mwana wanga wamkazi, osati kamodzi mwa mwana wanga, ngakhale c-peptide yake imakhala yoyipa. Kodi zingatheke bwanji? Ndipo nthawi yakwana yolumikizira insulini, ndi mashupi ati? Kupatula apo, mwachidziwikire, posachedwa bwino?

Nthawi zina ndimawona shuga wowonjezereka mwa mwana wanga wamkazi, osati kamodzi mwa mwana wanga, ngakhale c-peptide yake imakhala yoyipa. Kodi zingatheke bwanji?

Osadandaula ndi izi, zimachitika

Ndipo nthawi yakwana yolumikizira insulini, ndi mashupi ati?

Ndikadakhala kuti ndine inu, ndikadasinthira banjali prophylactically ku chakudya chochepa cha carb, ndikupitilirabe kuyeza shuga, makamaka milandu ya chimfine, poyizoni wa chakudya kapena zinthu zina zovuta. Mudzamvetsetsa mukamafunika kuyamba kulandira chithandizo ndi insulin. Simuyenera kukhala ndi shuga 7-8, muyenera kugwetsa ndi jakisoni.

Moni Sergey! 10/11/1971, kulemera makilogalamu 100, kutalika 179 cm.
07/11 / 2018- shuga 6.0 mmol / l
glycated hemoglobin 7.5%
08/11 / 2018- glucose 5.0
glycated hemoglobin 6.9%
09/11/2018-shuga 6.8
glycated hemoglobin 6.0

Sindikumva bwino. Anali pa nthawi ya endocrinologist pa mayeso akuthupi. Adayamba kuyesa mayeso ndipo izi ndi zotsatira zake. Ndimayesetsa kutsatira zakudya zamafuta ochepa. Dzulo, ndidapereka magazi, motsutsana ndi endocrinologist, kuti apange insulin ndi c-peptide: insulin 13.2, c-peptide 4.6 ng / ml.
C-peptide imakwezedwa. Mungalangize chiyani?

Zakudya zochepa zama carb, metformin, zolimbitsa thupi. Osaba jakisoni.

Sindikumva bwino

Izi ndizakanthawi. Pakakumana ndi vuto la mtima, miyendo imayamba kuzimiririka, kulephera kwa impso kapena khungu chifukwa chake - mudzamva kuti sizikuwoneka zokwanira.

Moni Sergey!
Wazaka 40, kutalika 176 cm, kulemera 87
Ndinkakhala pakudya chamafuta ochepa kwa miyezi 1.5, nditataya 3-4 makilogalamu, kenako ndimayesa mayeso mu labotale yolipira:
glycated hemoglobin 5.9%, glucose 4.9, C-peptide 0.89 ng / ml.
Zomwe zimayesa mayeso ndi ludzu losalekeza, kumanjenjemera m'miyendo.
Mungalangize chiyani?

Muyenera kumvetsetsa momwe njira yanu ikuyendera. Pitilizani kudya, bwerezani mayeso pambuyo pa miyezi 1 kapena 2. Palibe chifukwa chodikirira miyezi itatu. Kutengera zotsatira, sankhani ngati mungabayire insulin. Mwina zizindikiro zomwe zikukuvutitsani zidzachoka panthawiyi.

Zingakhalenso bwino kusanthula impso, monga tafotokozera apa - http://endocrin-patient.com/diabetes-nefropatiya/. Ngati zonse zikhala bwino ndi iwo, yambani kutenga metformin.

Tsiku labwino Mwa ine, lembani 1. Zdavali buluu, mwala 3, c-peptide nthawi yoyamba 0.64 (yabwinobwino 0.81-3.85), glogovanii hemoglobin 5.3, tsukor nasche 4.6. Nthawi ina, pakatha miyezi itatu, c-peptide ndi 0.52. Ndikuyeza kupita patsogolo kwa nyumba yokhala ndi glucometer masiku 6.6 ambiri azaka 1. Mukutanthauza chiyani?

Tsoka ilo, mwana amakula T1DM. Munatha kudziwa ngakhale zizindikirazi zisanawonekere - ketoacidosis, kupumulanso, etc.

Samutsani mwana wanu kupita naye ku chakudya chochepa kwambiri. Kupanda kutero, mavuto sangapewe.

Moni, moni! Matenda a 2 a shuga ali ndi zaka 20, onenepa kwambiri, miyezi 4 yomaliza pa chakudya chama carb, pang'onopang'ono kuchepa thupi, tsiku ndi tsiku shuga amakhala wabwinobwino, koma pamimba yopanda kanthu amakhala wolemera. Posachedwa mayeso a c-peptide. Zotsatira zakuthamanga: 2.01 ng / ml ndi chizolowezi cha labotale yathu 1.1 -4.4. Zikuwoneka kuti ndizabwino, koma kenako ndidakumbukira kuti panthawi yomwe amawunikira, shuga anga anali 8.5 mmol / l. Kodi mukuganiza kuti, ngati shuga anali wabwinobwino, ndiye kuti c-peptide inali yathanzi pompopompo?

Kodi mukuganiza kuti, ngati shuga anali wabwinobwino, ndiye kuti c-peptide inali yathanzi pompopompo?

Ili ndi funso longoganizira chabe lomwe silingayankhidwe chimodzimodzi.

Ngati mukufuna kukhala ndi moyo, muyenera kuchita zomwe zalembedwa apa - http://endocrin-patient.com/sahar-natoschak/. Mokulira, muyenera jekeseni wa insulin pang'ono, kuwonjezera pa kutsatira zakudya. Osatengera zotsatira za kuwunika pa C-peptide. Ngati kumwa mapiritsi a glucophage nthawi yayitali usiku sikungathandize kokwanira.

Moni. Mwanayo ali ndi miyezi isanu ndi itatu, kutalika 73,5, kulemera kwa 8440. Kuyesa: shuga 6.4 (yachilendo 3.3-5.5), glugated hemoglobin 6.3 (wabwinobwino mpaka 6), wokhala ndi peptide 187 (wabwinobwino kuyambira 260). Onse odzipereka pamimba yopanda kanthu. Ndiuzeni, kodi tili m'mbuyomu? Mukupangira chiyani? Zikomo

Sindikudziwa za ana a nthawi ino

Bwerezani mayeso kamodzi miyezi ingapo. Ngati zotsatirazi sizikuyenda bwino, pang'onopang'ono pitani ku chakudya chamafuta ochepa mutangoyamba kudya zakudya zowonjezera.

Moni Mwanayo ali ndi zaka 4. Shuga 4.0 pamlingo wa 3.3-5.5, Glycosylated hemoglobin 4.2% pamlingo wa 4.0-6.0%, C-peptide 0.30 pamlingo wa 0.9-7.1, insulin 2, 0 pamlingo wa 2.1-30.8. Kodi mkhalidwe wa mwana ndi woopsa motani?!

Kodi mkhalidwe wa mwana ndi woopsa motani?!

Kuyesanso kwa C-peptide, makamaka mu labotale yosiyana. Mwina nthawi yoyamba yomwe anali kulakwitsa.

Moni. Mwanayo ali ndi zaka 2,5. 02/28/2019 amawunika insulin 5.3, C peptide 1.1, glycosylated hemoglobin 5.03%, shuga 3.9, atatha kudya atatha ola limodzi ndi theka 6.2. 03/18/2019 insulin 10,8, C peptide 1.0, glycosylated hemoglobin 5.2%, glucose 4.5. Kodi munganene chiyani kuchokera pazomwe tapenda? Zikomo chifukwa chofunsirachi.

Kodi munganene chiyani kuchokera pazomwe tapenda?