9 zotheka komanso zotsika mtengo zotumphukira za Rosuvastatin

Zotsatira zamankhwala Krestor zimaperekedwa, molingana ndi terminology yachipatala, yotchedwa "ma syonyms" - mankhwala osinthika omwe ali ndi chinthu chimodzi kapena zingapo zomwe zimagwira ntchito molingana ndi zomwe zimachitika mthupi. Mukamasankha mawu ofananitsa, osangoganizira mtengo wawo, komanso dziko lakapangidwe ndi mbiri ya wopanga.

Kufotokozera za mankhwalawa

Rosuvastatin ndi chosankha, chopikisana mu HMG-CoA reductase, enzyme yomwe imatembenuza 3-hydroxy-3-methylglutaryl coenzyme A kwa mevalonic acid, cholesterol presteror. Cholinga chachikulu cha ntchito ya rosuvastatin ndi chiwindi, pomwe kaphatikizidwe ka cholesterol (cholesterol) ndi katemera wa otsika kachulukidwe lipoproteins (LDL) amachitika.

Rosuvastatin imakulitsa kuchuluka kwa "hepatic" LDL pama cell, ndikumakulitsa kukhudzika ndi mphamvu ya LDL, yomwe imayambitsa kulepheretsa kaphatikizidwe kachulukidwe kakang'ono kwambiri ka lipoproteins (VLDL), potero kumachepetsa kuchuluka kwathunthu kwa LDL ndi VLDL.

Krestor ® imatsitsa kwambiri kuchuluka kwa LDL cholesterol (cholesterol-LDL), cholesterol yathunthu, triglycerides (TG), imakulitsa kuchuluka kwa kuchuluka kwa lipoprotein cholesterol (HDL-C), komanso kuchepetsa kuchuluka kwa apolipoprotein B (ApoV), non-HDL cholesterol, -LVONP, TG-VLDLP ndikuwonjezera kuchuluka kwa apolipoprotein AI (ApoA-I) (onani matebulo 1 ndi 2), kumachepetsa kuchuluka kwa LDL-C / HDL-HDL, cholesterol yathunthu / HDL-C ndi HDL-C / HDL-C ndi Chiwerengero cha ApoB / ApoA-1

The achire zotsatira amakula mkati mwa sabata limodzi atayamba mankhwala ndi Krestor ®, pambuyo 2 milungu chithandizo ukufika 90% ya pazotheka kwambiri. Achire achire kwambiri nthawi zambiri amakwaniritsidwa ndi sabata la 4 ndikuchiritsira ndikugwiritsika ntchito mosalekeza.

Gome 1 ndi 1a.Mlingo wothandizidwa ndi odwala chachikulu hypercholesterolemia (mtundu IIa ndi IIb malinga ndi Fredrickson) (kusintha kosinthidwa kwapakati poyerekeza ndi mtengo woyambira).

Krestor ® imagwira ntchito mwa odwala akuluakulu omwe ali ndi hypercholesterolemia yokhala ndi hypertriglyceridemia, osatengera mtundu, jenda kapena msinkhu, incl. Odwala matenda a shuga ndi matenda am'magazi.

Mu 80% ya odwala omwe ali ndi mtundu wa IIa ndi IIb hypercholesterolemia malinga ndi Fredrickson (kuchuluka koyamba kwa cholesterol ya LDL ndi pafupifupi 4.8 mmol / L) pomwe akumamwa mankhwalawa pa 10 mg, kuchuluka kwa cholesterol ya LDL kumafika pazosakwana 3 mmol / L.

Odwala omwe ali ndi hypertriglyceridemia ndimatenda oyamba a TG kuyambira 273 mpaka 817 mg / dl omwe adalandira Krestor ® muyezo wa 5 mg mpaka 40 mg kamodzi patsiku kwa masabata a 6, kuchuluka kwa TG m'magazi a magazi kunachepetsedwa kwambiri (onani tebulo 2).

Mphamvu yowonjezera imawonedwa limodzi ndi fenofibrate pokhudzana ndi kuchuluka kwa triglycerides komanso nicotinic acid mu lipid kutsitsa Mlingo pokhudzana ndi kuchuluka kwa HDL-C.

Pakufufuza kwa METEOR, komwe kumaphatikizapo odwala 984 azaka zapakati pa 45-70 omwe ali ndi chiopsezo chochepa chotenga matenda a mtima (10-chiopsezo cha Framingham sikelo yochepera 10%), kuchuluka kwa LDL cholesterol ya 4.0 mmol / l (154,5 mg / dl) ndi subclinical atherosulinosis ( omwe adayesedwa ndi makulidwe a intima-media complex of the carotid artery - TCIM), mphamvu ya rosuvastatin pa makulidwe a intima-media tata idaphunziridwa. Odwala adalandira rosuvastatin pa mlingo wa 40 mg / tsiku kapena placebo kwa zaka ziwiri.Mankhwala a Rosuvastatin anachepetsa kwambiri kupitilira kwa TCIM yayikulu pazigawo 12 za chotupa cha carotid poyerekeza ndi placebo ndi kusiyana kwa -0.0145 mm / chaka. Poyerekeza ndi zoyambira zenizeni mu gulu la rosuvastatin, kuchepa kwa mtengo wapamwamba wa TCIM ndi 0.0014 mm / chaka (0.12% / chaka (kusiyana kwakukulu)) kunadziwika poyerekeza ndi chiwonetsero ichi ndi 0.0131 mm / chaka (1.12% / chaka (p 1/100) , 1/1000, 1/10000, Zolemba Zogwirizana

Nthawi zambiri, matenda amamufika munthu pomwe sanakonzekere kukumana nawo. Matenda a ma virus ndi omwe amadwala kwambiri masiku ano. Pamodzi ndi iwo, matenda nthawi zambiri amapezeka omwe amakhudza dongosolo la kupuma. At.

Mankhwala achilengedwe anapulumutsa anthu kumayambiriro kwa nthawi. Maphikidwe achilengedwe ochiritsira anthu amakono sanatayidwe. Chithandizo cha zilonda zam'mimba zam'mimbazi ndi wowerengeka azitsamba zimasiyana mosiyanasiyana. Mwachilengedwe.

Mphuno yathanzi mumphaka imatha chifukwa cha zifukwa zingapo. Nthawi zambiri, kumeta kwamkati mwa nyama kumawonekera chifukwa cha chimfine. Nthawi zina matendawa amakhala chifukwa cha chifuwa kapena matenda ena opatsirana.

Zolemba pazipilala

Chithandizo chogwira mankhwalawa ndi mchere wa calcium wa rosuvastatin. Kuphatikiza apo, kapangidwe kameneka ndikuphatikiza zina zingapo, zomwe zili ndi gawo lake:

1. Microcrystalline cellulose ndi adsorbent yabwino yomwe imachotsedwa osasinthika kuchokera mthupi la munthu. Mu kapangidwe kake ka mankhwalawa, imagwira ntchito monga filler ndi chinthu chomwe chimagwira kulumikiza zinthu zonse.
2. Lactose Monohydrate. Zogwiritsidwa ntchito pokonzanso kukoma kwa mankhwalawa. Komabe, izi zimapangitsa kuti pakhale zovuta kutenga mapiritsi a anthu omwe ali ndi vuto la tsankho kapena lactase.
3. Calcium calcium Ichi ndi chipangizo chophatikizira, chomwe chimaphatikizapo zitsulo zamchere ndi phosphoric acid. Kuphatikizika kwa mapiritsi kumathandizira kuti mumvetsetse zomwe zimagwira.
4. Magnesium wakuba. Imathandizira njira yojambulira matabuleti ndipo imagwira ntchito ngati chosungira bwino m'thupi.
5. Hydroxypropyl methylcellulose ndizowonjezera zapadera zothira madzi zomwe ndizofunikira pakupanga mawonekedwe a kipimo.
6. Povidone imagwira ntchito ngati sorbent yomwe imalepheretsa zinthu zina zoyipa m'thupi, kuphatikizapo zomwe zimapangidwa chifukwa cha zochita za rosuvastatin.
7. Triacetin ndi chowonjezera chovomerezeka cha chakudya (E1518). Monga gawo la mapiritsi, imagwira ntchito ngati pulasitiki ndi moisturizer, yomwe ndiyofunikira kuti ichitike.
8. Utoto - iron oxide ndi titanium dioxide ndizowonjezera zotetezeka kusintha mawonekedwe.

Mapiritsi a Rosuvatatin, omwe amagwiritsidwa ntchito ngati cholesterol pamwamba pazomwe amapangira, amapangidwa ndi makampani angapo azamankhwala pansi pa mayina osiyanasiyana. Onsewa ndi ma fanizo achindunji, ndiye kuti ali ndi chinthu chimodzi chogwira ntchito.

Mankhwala oyamba a Krestor amapangidwa ndi kampani yaku Chingerezi ndipo ali ndi mbiri ngati mankhwala apamwamba kwambiri. Mankhwala ena onse omwe akuphikidwa ndi rosuvastatin ndi ma genetic.

Amasiyana ndi zoyambirira mumtengo ndipo amatha kukhala ndi mawonekedwe ena othandizira, omwe samawakhudza kwambiri. Mfundoyi iyenera kukumbukiridwa ndi chidwi chochulukirapo pazinthu zina.

Zotsatira za pharmacological

Mankhwala a hypolipidemic ndi osankha, oletsa kupikisano a HMG-CoA reductase, enzyme yomwe imatembenuza 3-hydroxy-3-methylglutaryl coenzyme A to mevalonate, patsogolo pa cholesterol (Xc). Cholinga chachikulu cha zochita za rosuvastatin ndi chiwindi, pomwe kaphatikizidwe ka Xc ndi katchulidwe ka LDL kamachitika.

The achire zotsatira zimawonekera mkati 1 sabata atayamba Krestor mankhwala, pambuyo 2 milungu chithandizo ukufika 90% ya pazotheka kwambiri. Achire achire kwambiri nthawi zambiri amakwaniritsidwa masabata anayi ndipo amasungidwa nthawi zonse.

Pafupifupi 90% ya mlingo wa rosuvastatin wamasulidwa osasinthika ndi ndowe. Chotsalazo chimatulutsidwa mkodzo.

Mitu ya mankhwalawa

Ma Analogs ndiotsika mtengo kuposa oyambira, ndipo wodwalayo amatha kuyimitsa payekhapayekha mankhwala ena, kuyang'ana kuthekera kapena kupezeka kwa mankhwalawo mufakisi. Amasiyana mwanjira yothandiza, yomwe imalumikizidwa ndi mtundu wa zosakaniza zomwe zimagwiritsidwa ntchito komanso kusiyana kwazomwe zimachitika. Ma Analogs omwe amagwira ntchito ndi rosuvastatin:

1. Crestor. Mankhwala enieni opangidwa ku UK. Ili ndi bioavailability yayikulu, imathandizira mwachangu ndi cholesterol kuposa yachilendo. Ili ndi mtengo wokwera kwambiri poyerekeza ndi zida zamagetsi.
2. Akorta, Rosuvastatin Canon ndi Rosuvastatin SZ amatulutsa malonda aku Russia. Ali m'gulu la analogi zotsika mtengo. Koma ali otsika bioavailability, pang'onopang'ono kupanga ndende mu thupi zofunika kukwaniritsa pazipita. Amachotsedwa msanga m'thupi.
3. Mertenil. Wopanga - Hungary. Ilinso ndi bioavailability yotsika, kotero zochizira zimachitika pambuyo pake kuposa mankhwala oyambirirawo.
4. Rosulip ndi mankhwala ena ochokera kwa opanga aku Hungary. Zilibe mtengo wokwera kwambiri. Amasiyanitsidwa ndi bioavailability yapamwamba, koma nthawi yomweyo, imadziunjikira pang'onopang'ono, ndikupanga kufunikira kwazowopsa.
5. Rosart amapangidwa ndi kampani yaku Iceland. Ili ndi zabwino zonse zamankhwala oyambira, zovuta zake zimaphatikizapo mtengo wake wokwera.
6. Rosistark. Kupanga kwa Croatia. Sichotsika ndi Rosart kapena Krestor mwanjira iliyonse, panthawi imodzimodzi imakhala ndi mtengo wokwera kwambiri.
7. Tevastor Amapangidwa ndi kampani yopanga mankhwala ku Israeli, imadziunjikira mwachangu mthupi ndipo imakhala ndi zotsatira zochizira. Ili ndi mtengo wokwera.
8. Roxer amapangidwa ndi kampani yotchuka ku Slovenia. Imakhala ndi mtengo wokwanira, wabwino bioavailability, koma umachotsedwa msanga mthupi ndipo pang'onopang'ono imakhala ndi zotsatira zochizira.
9. Rosucard ndimakonzedwe aku Czech. Pa mtengo wapakati, imakhala ndi bioavailability yayitali, koma kutsika kochepa kwambiri koyamba kwa chithandizo chochiritsira.

Mankhwalawa onse ndi ma analogi achindunji, i.e., okhala ndi chinthu chimodzi chogwira ntchito ndipo amafanana. Pochita, ndi chida chimodzi ndi chofanana, chomwe chili ndi mayina osiyanasiyana ogulitsa ndipo chimagulitsidwa pamitengo yosiyanasiyana. Pali mitundu yosiyanasiyana.

Mankhwala oterewa amakhala ndi vuto limodzi (pamenepa, lipid-kutsika), koma ali ndi magawo osiyanasiyana othandizira. Kusintha kwa analogi zotere kumatha kuchitika ndi dokotala.

Pharmacokinetics mu milandu yapadera yamankhwala

Jenda ndi zaka sizikhala ndi vuto lalikulu pa pharmacokinetics ya rosuvastatin.

Odwala omwe amachepetsa kwambiri aimpso, kuchuluka kwa plasma kwa rosuvastatin kapena N-dysmethyl sikusintha kwambiri.

Odwala omwe ali ndi vuto lalikulu la impso (CC 1/100, 1/1000, 1/10 000,

9 zotheka komanso zotsika mtengo zotumphukira za Rosuvastatin

• Zolemba pazipilala
• Mitu ya mankhwalawa

Rosuvastatin ndi mawonekedwe ake amafotokozedwera cholesterol m'magazi kuposa kale. Mankhwalawa ndi a gulu la statins omaliza (mibadwo 4). Poyerekeza ndi mankhwala ena omwe ali mgululi, rosuvastatin ndi njira yothandiza komanso yotetezeka.

Adapangidwa kuti apangidwe ndipo amawonetsera ma hydrophilic, chifukwa sichikhala ndi vuto lililonse pachiwindi.

Mankhwalawa amalepheretsa kupanga ma lipoprotein otsika kwambiri, omwe amakhala ngati chinthu chofunikira kwambiri kuchokera komwe cholesterol imapangidwira.

Kuphatikiza apo, kumwa mankhwalawa sikuyambitsa kukokana kwa minofu ndi ma pathologies ena kuchokera kumbali ya minofu. Mphamvu yofunikira imawonekera kale sabata pambuyo poyambira kugwiritsa ntchito, ndipo pakatha milungu 4 imakhala yotalikirapo ndipo ndi chithandizo chanthawi zonse chimatenga nthawi yayitali. Makhalidwe amenewa amapangitsa rosuvastatin kukhala mankhwala okwera kwambiri kwa odwala omwe ayenera kuchepetsa cholesterol.

Crestor: malangizo ogwiritsira ntchito, analogi, mitengo ndi malingaliro

1. Mawonekedwe ndi kipimo
2. Kuthekera kwama pharmacological
3. Mankhwala
4. Pharmacokinetics
5. Ndani akuwonetsedwa Crestor
6. Momwe mungagwiritsire ntchito
7. Zotsatira zoyipa
8. Zoletsa ntchito
9. Kugwirizana kwina ndi mankhwala ena
10. Crestor: analogues
11. Kodi madokotala ndi odwala akuganiza chiyani za Crestor

Owerenga athu adagwiritsa ntchito bwino Aterol kutsitsa cholesterol. Kuwona kutchuka kwa malonda, tidaganiza zoperekera chidwi chanu.

Mutha kumverera bwino mu nyimbo yanu yanthawi zonse, ndipo mutatha kuyesedwa, phunzirani za hyperlipidemia - kuchuluka kwa cholesterol ndi triglycerides m'magazi. Kudwala kwa asymptomatic kumawonjezera chiopsezo cha zolembedwa za atherosulinotic - oyambitsa matenda a mtima ndi stroko.

Krestor, mankhwala othandiza a m'badwo wotsiriza omwe adapangidwira matenda a lipid metabolism, amathandiza kupewa zotsatira zowopsa.

Mawonekedwe ndi kipimo

Mtanda umagulitsidwa monga miyala. Kutengera ndi kuchuluka kwa mankhwala othandizira, mitundu ingapo ya mankhwala imapangidwa:

1. Zomwe zimalembedwera chikasu komanso zojambula ZD4522 5 ndizowoneka bwino, kuzungulira, komwe kumakhala 5 g ya rosuvastatin.
2. Mapiritsi a Crestor pinki okhala ndi mawonekedwe ofanana ndi ZD4522 10 ali ndi 10 mg yogwira ntchito.
3. Mapiritsi amtundu womwewo ndi ZD4522 20 - rosuvastatin 20g.
4. Kuchuluka kwazomwe kumagwira ntchito (49 mg) kuli pamapiritsi a pinki oval omwe ali ndi ZD4522.

Mitundu yonse ya mankhwalawa (kuphatikiza ma analogues) ndi mankhwala

Mankhwala

Krestor ikulepheretsanso kuchepa kwa HMG-CoA, enzyme yomwe imayang'anira kupanga mevalonate, cholesterol precursor. Rosuvastatin amagwira ntchito mu chiwindi - chimodzi mwazinthu zazikulu za chandamale.

Statin imachepetsa kuchuluka kwa lipoproteins ndi kachulukidwe kotsika kwambiri komanso kotsika kwambiri mwa kutsinikiza kaphatikizidwe kake, komanso kupanga HDL yowonjezera pakuyambitsa ndi kutsutsa kwa LDL. Zotsatira zake, mulingo wa cholesterol wathunthu, LDL ndi triglycerides umachepa. Nthawi yomweyo, kugwiritsidwa ntchito kwa HDL kumawonjezeka.

Rosuvastatin imathandiza ku hypercholesterolemia kuphatikiza kapena popanda hypertriglyceridemia odwala amuna kapena akazi, zaka komanso mtundu.

Zotsatira zakugwiritsira ntchito kwa Krestor, ndikuwunika ndi ndemanga kuchokera kwa ochita kafukufuku, zimawonedwa kumapeto kwa sabata loyamba la maphunzirowa, koma zotsatira zabwino (zopitilira 90%) zimatha kuwonekera pokhapokha masabata 2-4 atagwiritsidwa ntchito nthawi zonse.

Mosiyana ndi ma analogu ena, Krestor amakhala ndi zovuta zochepa pachiwindi. Gwiritsani ntchito limodzi ndi zakudya zochepa za cholesterol ndi mankhwala ena omwe amachepetsa cholesterol.

Ndani akuwonetsedwa Crestor

Mukasinthanitsa ndi Krestor ndi analogi, ndikofunikira kufotokozera pansi momwe agwiritsidwira ntchito.

Mankhwala enieni owonetsedwa:

• Ndi hypercholesterolemia (pulayimale kapena njira yapabanja),
• Pofuna kupewa matenda a sitiroko,
• Ndi hypercholesterolemia yosakanikirana,
• Pofuna kupewa matenda a mtima,
• Anthu omwe ali ndi atherosulinosis,
• Ndi hypertriglyceridemia.

Momwe mungagwiritsire ntchito

Njira zochizira ndi kumwa mankhwalawa zimapangidwa ndi adokotala potengera kupimidwa, chikhalidwe chaumoyo, matenda oyanjana.

Malamulo onse ogwiritsira ntchito Crestor:

• Piritsi siliyenera kuphwanyidwa.
• Nthawi yolandirira - njira iliyonse yabwino, yabwino kwambiri imatha kupezeka pogwiritsa ntchito usiku, chifukwa mafuta ambiri a cholesterol amapangidwa usiku.
• Kudya sikukhudza kutha kwa mankhwalawa.
• Maphunzirowa asanayambike, wodwalayo asinthana ndi kudya mafuta ochepa a cholesterol, omwe amayenera kuchitika pafupipafupi.
• Mlingo woyambirira wa Crestor (5-10g / tsiku) amasankhidwa payekha. Ngati zotsatira sizikumana ndi zomwe mukuyembekeza, mutha kusintha mankhwalawo kukhala 20 mg / tsiku, koma osapitirira mwezi umodzi. Mulingo woyenera kwambiri (40 mg / tsiku) umangokhala pachiwopsezo chotenga matenda a mtima komanso mtima. Wodwala wodwala kwambiri hypercholesterolemia ayenera kuyang'aniridwa ndi achipatala pafupipafupi, chifukwa kuyambitsa mavuto kumawonjezeka. Kuwunika kwa mbiri ya lipid kuti awongolere njira ya mankhwalawa kuyenera kuchitika pakadutsa sabata lililonse la 2-4.

Pankhani ya bongo, mankhwala enaake sagwiritsidwa ntchito. Kuchiza ndi chizindikiro, poganizira kuchuluka kwa poizoni. Ngati ndi kotheka, pezani njira zothandizira.

Zotsatira zoyipa

Potsatira mosamalitsa malangizo omwe adokotala adapereka, odwala samadandaula chifukwa chogwiritsa ntchito Krestor. Ndipo komabe, malangizo ogwiritsira ntchito akuchenjeza za mwayi wokhala ndi zotsatira zosafunikira. Zambiri zimakhazikitsidwa ndi maphunziro azachipatala.

Mankhwala onse omwe ali pamwambawa ndi ma analogi a rosuvastatin, ndiye kuti, mankhwala omwe ali ndi chinthu chofanana. M'malo mwake, izi ndi zonse - mankhwala omwewo okhala ndi mayina osiyanasiyana ogulitsa ndikugulitsidwa pamitengo yamitundu yonse ndi yogulitsa (mtengo wotsatsa wamba udzaperekedwa pagome m'gawo lotsatira la kusindikiza). Palinso ma analogu osadziwika, ndiye kuti, mankhwala ochokera ku gulu limodzi la mankhwala (pano, reductase inhibitors) omwe ali ndi vuto lofananalo, koma ali ndi chinthu china chogwira ntchito. Mankhwalawa ndi ena osakhudzana ndipo amatha kutumizidwa ndi akatswiri pokhapokha malinga ndi data ya labotale.

Chithunzi chofananira cha mtengo wamafanizo a "Rosuvastatin"

Pakuwona bwino kwa phunziroli, lochitidwa mokomera ogula mankhwalawo omwe akufunsidwa, mndandandandawo uli ndi zofananira pamtundu wotsatira ndi kuchuluka: 10 mg ya rosuvastatin pa piritsi, 30 mapiritsi amodzi. Njira iyi yakhazikitsire ndiyodziwika kwambiri pakati pa ogula, chifukwa chake ndikofunika kuperekera mankhwalawa mu maphunziro a pamwezi kuti mudziwe kuchuluka kwa kusintha kwa thupi la munthu ku rosuvastatin.

Mtengo wa "Rosuvastatin" komanso kuthekera kwakwe ndikusintha ndi analogues

Mu msika wogulitsa mankhwala "Rosuvastatin" mu mulingo wa 10 mg ndi kuchuluka kwa mapiritsi, zidutswa 30 zimagulitsidwa pamtengo kuchokera pa 380 mpaka 490 rubles, kutengera ndondomeko yamitengo ya wogulitsa ndi wogulitsa zamankhwala, komanso kutengera dera. Chifukwa chake, nthawi zambiri, choyambirira cha Rosuvastatin ndi chotsika mtengo kuposa ma analogues ake, ndipo mukupangiratu kugula ma analogu pokhapokha ngati mankhwala oyambirirawa sanapezeke mu izi. Kutengera ndi malingaliro omwe adayikidwa pagulu la anthu pa intaneti komanso pazosindikiza, titha kudziwa kuti ogula amakonda mankhwala oyamba.

Mfundo za mankhwalawa

Pharmacodynamics ya Krestor ndikuti imayambitsa enzyme yapadera yomwe imayang'anira kupanga cholesterol precursor kapena mevalonate.

Chithandizo chogwira mankhwalawa chimagwira mwachindunji m'chiwindi, chomwe chimapanga cholesterol.Enzyme iyi imathandizira kuchepetsa kupanga ma lipoprotein otsika kwambiri, omwe amathandiza kuchepetsa kuchuluka kwa cholesterol m'thupi, komanso triglycerides.

Kuphatikiza apo, cholesterol yapamwamba kwambiri imakwera. Mankhwalawa ndi othandiza kwa odwala azaka zilizonse, jenda ndi mtundu. Ndemanga zambiri za ogwiritsa ntchito zikuwonetsa kuti kugwiritsa ntchito Krestor kumawonekera kale sabata yoyamba yamaphunzirowa, pomwe kulimbitsa thupi kumatheka mukamaliza maphunzirowa mu masabata 2-4 ogwiritsa ntchito mosalekeza.

Mtanda, mosiyana ndi mawonekedwe ake ambiri, umakhala ndi vuto lochepa pa chiwindi cha munthu. Ndikofunika kuphatikiza kugwiritsidwa ntchito kwake ndi zakudya zapadera, komanso mankhwala ena omwe amatsitsa kuchepetsa cholesterol.

Mankhwala a pharmacokinetic a mankhwalawa ndi awa:

1. Mulingo woyamwa. Kuchuluka kwa statin kumawonekera m'magazi pambuyo pa maola 5, mutatha kugwiritsa ntchito mankhwalawa.
2. Pogawa thupi. Malo akuluakulu a Krestor ndi chiwindi, chomwe chimapanga mafuta m'thupi. Voliyumu yogawa ndi 134 malita.
3. Muli kuchuluka kwa kagayidwe. Kwa Krestor, ili pafupifupi 10%.
4. Munjira yotulutsira. Kuchuluka kwa mankhwala omwe amachotsedwa m'thupi ndi pafupifupi 90% pasanathe maola 19 oyang'anira.

Zaka za wodwalayo, komanso jenda, sizikhala ndi mphamvu iliyonse pamankhwala a pharmacokinetic.

Muyenera kuganizira za kukhalapo kwa matenda a impso. Chifukwa chake, kufatsa komanso kufatsa kwamankhwala ochepa sikumakhudza kuchuluka kwa statin, pomwe kuli koopsa, kuchuluka kwa rosuvastatin kumawonjezeka katatu.

Kukhalapo kwa ma pathologies a chiwindi sikuti sikukhudza kugwiritsa ntchito mankhwalawa.

Krestor - fanizo la mankhwala ndi zikugwiritsira ntchito

Analogue yotsika mtengo kapena yolowa m'malo mwa mankhwalawo, ngati wodwalayo wasankha kuigwiritsa ntchito, amafunika kusamala.

Mwanjira ina, odwala omwe aganiza kuti asankhe mankhwala oyamba ndi mankhwala osokoneza bongo ayenera kufunsa dokotala kapena awone zomwe akuwonetsa.

Poyamba, Krestor amalimbikitsa kugwiritsa ntchito:

• ndi hypercholesterolemia,
• monga kupewa kugwidwa ndi matenda a mtima,
• ndi hypercholesterolemia yosakanikirana,
• anthu omwe ali ndi atherosulinosis,

Kuphatikiza apo, tikulimbikitsidwa kugwiritsa ntchito mankhwalawa pamaso pa hypertriglyceridemia.

Malangizo ogwiritsira ntchito mankhwalawa

Krestor, monga mankhwala ena aliwonse, ali ndi zake zomwe azigwiritsa ntchito.

Monga lamulo, ndi dokotala yemwe amasankha kuchuluka kwa mankhwalawa omwe wodwala ayenera kugwiritsa ntchito. Amachita izi pamaziko a kafukufuku ndi zotsatira za kusanthula.

Kuphatikiza apo, momwe wodwalayo alili komanso kupezeka kwa matenda opatsirana amakhudzidwa.

Chifukwa chake, Krestor ayenera kumwedwa motere:

1. Pogaya piritsi la mankhwalawa.
2. Nthawi yoyenera kwambiri kuvomerezedwa imadziwika kuti ndi yamadzulo polumikizana ndi kuchuluka kwa mafuta a cholesterol m'thupi.
3. Kudya sikukhudza phindu la mankhwalawa.
4. Asanayambe maphunziro, wodwalayo amakulimbikitsidwa kuti azitsatira zakudya zochepa zamafuta m'thupi.
5. Poyamba, ndikofunikira kumwa mankhwalawa kuchuluka kwa 5-10 g patsiku. Komabe, mlingo wa mankhwalawa umasankhidwa yekhayo komanso dokotala. Pokhapokha patatha mphamvu ya kuchuluka kwa mankhwala omwe atengedwa, amatha kuwonjezereka mpaka 20 milligram, koma pakatha mwezi umodzi. Kuchuluka kwa ma milligram 40 kumayikidwa pokhapokha ngati chiwopsezo cha matenda amtima chakwera kwambiri. Odwala omwe ali ndi vuto lalikulu la hypercholesterolemia ayenera kuyang'aniridwa ndi achipatala nthawi zonse kuti apewe zoyipa.

Ngati wodwalayo ali ndi mankhwala osokoneza bongo mopambanitsa, m'malo mwakugwiritsira ntchito mankhwala ena alionse, njira zothandizira zimagwiritsidwa ntchito.

Zofanizira zazikulu za Crestor

Mumsika wamakono wamankhwala, kuchuluka kwa mankhwala kumawonetsedwa. Komabe, monga lamulo, mankhwala oyambirirawo ndiokwera mtengo kwambiri ndipo si wodwala aliyense amene ali ndi mwayi wowagula.

Motere, opanga ambiri adaganiza zoyambitsa ndi zoyambirira. Monga lamulo, kusiyana kwakukulu pakati pa mankhwalawa ndi mtengo.

Kuphatikiza apo, ndikofunikira kuganizira kuti mankhwala aliwonse kapena mtundu wake wa mankhwalawa uyenera kufotokozedwa ndi dokotala yemwe aziganizira zonse zomwe zimachitika chifukwa cha matendawa komanso momwe wodwalayo alili.

Mwa ena odziwika bwino ndi awa:

1. Akorta. Mnzake waku Russia. Ndizofanana mu kapangidwe kake, komanso m'zisonyezo zokugwiritsira ntchito. Amagwiritsidwa ntchito pamaphunziro ataliatali monga momwe afotokozera.
2. Mertenil. Chofunikira chachikulu ndi rosuvastatin. Ndi analogue yakunja yomwe imagwirizana mu mankhwala ake ndi mankhwala oyamba. Kupangidwa ku Hungary ndikuthandizira kuchepetsa cholesterol. Mtengo - 510-1700 rubles.
3. Rosistark. Chida chothandiza chomwe chimagulitsidwa pamtengo wotsika mtengo kwambiri. Musanagwiritse ntchito, tikulimbikitsidwa kuti muwerenge malangizo kuti muchepetse zovuta zomwe zimagwiritsidwa ntchito. Mtengo pa avareji kuyambira 250 mpaka 790 rubles.
4. Rosucard. Mnzake wina waku Russia. Zomwe zimagwiritsidwa ntchito ndizofanana, komanso kuchuluka kwa piritsi limodzi. Contraindicated ngati mukumvera kwambiri ntchito yogwira zosakaniza.
5. Rosulip. Kugwiritsa ntchito mankhwalawa ndikofunikira pa hypercholesterolemia, hypertriglyceridemia, kuchepetsa kupita patsogolo kwa atherosulinosis komanso kupewa matenda a mtima. Zimapangidwa ku Hungary ndipo zimawononga ma ruble 390-990.
6. Roxer. Hypolipidemic mankhwala. Sitikulimbikitsidwa kugwiritsa ntchito nthawi yapakati, mukamayamwitsa, komanso ana osakwana zaka 18. Mtengo wapakati ndi ma ruble 440-1800 aku Russia.
7. Tevastor Mankhwala omwe ayenera kugwiritsidwa ntchito kwa pafupifupi milungu 4 kuti muwonekere. Zimapangidwa ku Israeli ndipo zimagula pafupifupi ma ruble a 350-1500.
8. Novostat. Chofunikira chachikulu ndi atorvastatin. Mankhwalawa amapangidwa ku Russia.

Mtengo wa mankhwalawa ndiwosiyana ndipo umasiyana kuchokera ku ruble 500 mpaka 3000 kapena kupitirira.

Ndemanga ya odwala ndi madokotala za Crestor

Malinga ndi lingaliro la madotolo aluso, Krestor adakhala mankhwala othandiza kwambiri omwe amathandiza kuchepetsa magazi m'thupi.

Odwala ambiri omwe atenga nawo gawo pazoyeserazi, cholesterol chisonyezo chinali kuyandikira mwama sabata limodzi, maphunziro atayamba.

Mapiritsi omwe ali pamsika wa mankhwalawa ndi apamwamba kwambiri, chifukwa chake kugwiritsa ntchito mankhwalawa ndikwapamwamba kwambiri. Monga lamulo, njira ya mankhwalawa sikuyambitsa mavuto.

Ponena za malingaliro a odwala, zimagwirizana mokwanira ndi malingaliro a madokotala. Nthawi zambiri, pamakhala malingaliro a odwala omwe adadwala matenda a stroko kapena a mtima.

Chifukwa chake, titha kunena kuti mankhwalawa ndi othandizadi. Zimangotengera nthawi kuti zizindikirazo zibwerere mwakale.

Ndingatenge ma statins ndikamuuza katswiri mu kanemayu munkhaniyi.

• Imakhazikika pamisempha ya shuga kwa nthawi yayitali
• Imabwezeretsa kapangidwe ka insulin

Pharmacology

Wothandizira hypolipidemic kuchokera ku gulu la ma statins, choletsa wa HMG-CoA reductase. Malinga ndi lingaliro la kupikisana kwa mpikisano, molekyu ya statin imamangiriza mbali yomweyo ya coenzyme A receptor komwe enzyme iyi imafikira. Gawo lina la molekyu ya statin imalepheretsa kusintha kwa hydroxymethylglutarate kukhala mevalonate, wapakatikati mwa kapangidwe ka mamolekyulu a cholesterol.Kuletsa kwa ntchito ya HMG-CoA reductase kumabweretsa zotsatizana zotsatizana, zomwe zimapangitsa kutsika kwa zinthu zamafuta a cholesterol komanso kuwonjezereka kwa ntchito ya LDL receptors ndipo, motero, inapititsa katemera wa LDL cholesterol (Xc).

Hypolipidemic zotsatira za ma statins zimagwirizanitsidwa ndi kuchepa kwa cholesterol yathunthu chifukwa cha LDL cholesterol. Kutsika kwa LDL kumadalira mlingo ndipo sikwachizere, koma kokwanira.

Ma Statin samakhudza zochitika za lipoprotein ndi hepatic lipases, sizikhudza kwambiri kaphatikizidwe ndi katemera wa mafuta aulere acids, chifukwa chake, zotsatira zawo pamlingo wa TG ndizachiwiri komanso mosazungulira kudzera pazotsatira zawo zazikulu pakuchepetsa LDL-C. Kutsika kwapakati pa TG pamankhwala omwe amapezeka ndi ma statins akuwoneka kuti kumalumikizidwa ndi ma protein a hepatocytes omwe amaphatikizidwa ndi catabolism ya STDs, yomwe ili pafupifupi 30% TG.

Kuphatikiza pa kuchepetsa lipid-kuchepetsa, ma statins ali ndi zotsatira zabwino pa endothelial dysfunction (preclinical sign of atherosclerosis oyambirira), pakhoma la mtima, atheroma state, kusintha magazi m'thupi, kukhala ndi antioxidant, antiproliferative katundu.

The achire zotsatira kuwonekera mkati 1 sabata. pambuyo pa kuyamba kwa mankhwala ndipo pakatha milungu iwiri ya chithandizo ndi 90% ya momwe mungathere, zomwe nthawi zambiri zimachitika ndi masabata anayi ndipo pambuyo pake zimatha.

Analogs mwa chisonyezo ndi njira yogwiritsira ntchito

Kuphatikizika kosiyanasiyana, kungagwirizane mukuwonetsa ndikugwiritsa ntchito njira

Kuti tipeze mndandanda wamtengo wotsika mtengo wa mankhwala okwera mtengo, timagwiritsa ntchito mitengo yomwe imatipatsa mankhwala opitilira 10,000 mu Russia yonse. Dongosolo la mankhwala osokoneza bongo ndi fanizo lawo limasinthidwa tsiku ndi tsiku, chifukwa chake zambiri zomwe zimaperekedwa patsamba lathu zimakhazikika pofika lero. Ngati simunapeze analogue yosangalatsa kwa inu, chonde gwiritsani ntchito kusaka pamwambapa ndikusankheni mankhwala osangalatsa kuchokera pamndandanda. Patsamba lililonse la iwo mupeza zosankha zonse za mankhwala omwe mungafune, komanso mitengo ndi ma adilesi omwe amapezekamo.

Ndi ma analogu ati omwe angalowe m'malo mwa rosuvastatin?

Rosuvastatin ndi mankhwala ogwiritsidwa ntchito kukonza mafuta kagayidwe. Mankhwalawa amagwiritsidwa ntchito kwambiri popewa komanso kuchiza matenda a mtima.

Zokonzekera zomwe zimakhala ndi rosuvastatin monga chinthu chogwira ntchito zimapangidwa ndi opanga ambiri akunja ndi apabanja. Mankhwala oyamba otchedwa Crestor amapangidwa ku UK ndi Astra Zeneca. Mankhwala otsala omwe ali ndi rosuvastatin ndi ma genetic ake.

Mwachitsanzo, Rosuvastatin Canon, Torvacard, Rosulip, Akorta, Rosistark, Tevastor, Rosart, Rosuvastatin-SZ, Mertenil.

Rosuvastatin "ikhoza m'malo mwa analogue yabwino

Mankhwala enieni ndi zida zamagetsi

Kodi ma jeniki ndi chiyani ndipo amasiyana bwanji ndi zoyambirira? Mitundu ya jini imatulutsanso mankhwala oyamba. Zomwe zimagwiritsidwa ntchito m'mankhwala oyamba komanso ma jenolo ndizofanana. Ndipo kapangidwe ka zinthu zothandiza zimatha kusiyanasiyana.

Chifukwa chiyani ma analogu ndi otsika mtengo kuposa oyambira? Chowonadi ndi chakuti wopanga zinthu zoyambirira ndi "mpainiya".

Izi zikutanthauza kuti amawononga ndalama zambiri pochita kafukufuku wamankhwala ndi zamankhwala, komanso amalandila patent ya mankhwala atsopano. Njira zokwera mtengozi zimaphatikizidwa ndi mtengo wamankhwala.

Opanga ma jeniki samakhala ndi ndalama zochuluka choncho, amangopanganso chida, chomwe chimawalola kugulitsa pamtengo wotsika kwambiri.

Chifukwa chake, lingalirani za mankhwala omwe ali chithunzi cha Rosuvastatin (Crestor) woyambayo.

Anthu odwala matenda ashuga panthawi ya mankhwala a Krestor ayenera kusamala makamaka

Rosuvastatin Canon

Chimodzi mwa zinthu zoterezi ndi Rosuvastatin Canon. Mankhwala amapezeka mu mawonekedwe a mapiritsi a 10, 20 ndi 40 mg. Mankhwalawa ali ndi katundu wokhala ndi lipid. Zizindikiro zakusankhidwa kwa Rosuvastatin Canon ndi:

• hypercholesterolemia yoyamba,
• mabanja homozygous hypercholisterinemia,
• okwera magazi triglycerides,
• kupewa mavuto a atherosulinosis,
• kupewa zovuta za IHD popanda zizindikiro zamankhwala,
• kuwonjezera zakudya pachiwopsezo cha kukhala ndi atherosulinosis.

Mankhwalawa amathandizidwa ndi maphunziro azitali, kuyambira ndi ochepera. Patatha milungu 3-4 atayamba kulandira chithandizo, wodwalayo amayesedwa kuti ayesedwe magazi kuti ayang'anire momwe mankhwalawo alili.

Ngati mulingo wa cholesterol ndi triglycerides m'magazi ukanatsika kapena utachepa pang'ono, mulingo wa mankhwalawa uyenera kusinthidwa.

Kuchulukitsa mlingo kumachitika pang'onopang'ono pang'onopang'ono kuwunika kwa magazi.

Rosuvastatin Canon - Wothandizira wa hypolipidemic kuchokera ku gulu la ma statins, choletsa wa HMG-CoA reductase

Kodi ma statins sayenera kulembedwa liti?

Rosuvastatin, monga ma statin ena, ali ndi zotsutsana zingapo, momwe amaletsedwa kupereka mankhwala a gululi.

1. Kusagwirizana ndi chinthu chomwe chikugwirira ntchito kapena mawonekedwe othandizira a mtundu wa Mlingo.
2. Matenda a chiwindi mu gawo logwira kapena magawo okwera a transaminase achilendo osadziwika kuposa katatu.
3. Nthawi yobereka mwana ndi kuyamwitsa.
4. Kuperewera kwabwino kwa amayi olera.
5. Matenda a impso ndi chiwonetsero cha aimpso kulephera.
6. Ana ndi achinyamata ochepera zaka 18.
7. Myopathy
8. Nthawi ya mankhwala ndi cyclosporine.

Contraindation wa mankhwala a Rosuvastatin Canon ziyenera kukumbukiridwa poika mankhwala. Izi zimathandiza kuti pakhale zovuta kuchokera ku ziwalo zofunika kwambiri ndi machitidwe.

Mwina mavuto a rosuvastatin mankhwala

Ndi zovuta ziti komanso zovuta zomwe zimachitika ndikamagwiritsidwa ntchito ndi mankhwala oyambirirawa ndi othandizira a rosuvastatin? Mankhwala a Statin nthawi zambiri amaloledwa. Izi zikugwiranso ntchito kwa mitundu yoyambirira yamankhwala komanso zotsika mtengo za rosuvastatin.

Kugwiritsa ntchito ma statins kumatha kupweteketsa minofu.

Komabe, ngati mulingo wawonjezereka kapena ngati pali zovuta zina zamagulu ndi machitidwe, chithandizo cha Rosuvastatinomy chofanizira chingayambitse kuwoneka kosakhudzidwa.

1. Edema ya Quincke komanso zochitika zina zamthupi zomwe zimachitika.
2. Matenda a endocrine dongosolo (mtundu 2 shuga mellitus).
3. Matenda a Dyspeptic.
4. Kutupa kwa kapamba.
5. Kusokonezeka kwa chiwindi.
6. Kupweteka kwa minofu, myositis, rhabdomyolysis (chiwonongeko cha minofu ululu).
7. Matenda a impso.
8. Zosintha m'mayesero am'magazi ndi mkodzo.

Ngati mukukumana ndi chilichonse chosonyeza matenda omwe amayambitsidwa ndi matendawa, muyenera kufunsa dokotala. Katswiriyu adzazindikira moyenera matendawo ndipo ngati kuli kotheka, asinthe mawonekedwe ndi mankhwalawo.

Malangizo a kumwa mankhwala osokoneza bongo

Momwe mungatenge Rosuvastatin ndi mawonekedwe ake? Mankhwala oyenera amapereka chithandizo chokwanira komanso amachepetsa chiopsezo cha zovuta zomwe zili pamwambapa. Chifukwa chake, malamulo oyendetsera chithandizo ndi awa.

1. Mankhwala ayenera kumwedwa kwathunthu, osafuna kutafuna. Imwani mankhwalawo ndi madzi osakwanira.
2. Ngati mukufuna kumwa kachilomboka kakang'ono kuposa momwe piritsi limodzi lilili, mtundu wake ungagawidwe pakati.
3. Amayi amisinkhu yakubereka nthawi yapakati ayenera kugwiritsa ntchito njira zodalirika zolerera.
4. Ngati muli ndi pakati panthawi yochizira ndi ma statins, mankhwalawa ayenera kusiyidwa. Kuchotsa mimba sikofunikira.
5. Mankhwala, amaletsedwa kudziletsa kuchepetsa kapena kuwonjezera tsiku lililonse la mankhwalawa.
6. Ngati mankhwalawo adaphonya mwangozi, mankhwala ena amayenera kupitilizidwa malinga ndi chizolowezi.

Akatswiri salimbikitsa kuti azidzipatula okha

Tiyeneranso kudziwa kuti malinga ndi momwe mankhwala a statin amafunikira, muyenera kutsatira zakudya zochepa zamafuta ndi mafuta m'thupi. Chakudyacho chiyenera kukhala chochepa m'makilo, chokhala ndi mafuta ochepa a nyama momwe mungathere.

Mitundu yamafuta, nsomba ndi mkaka ziyenera kuthetsedweratu. Zakudya ziyenera kuphatikiza mapuloteni komanso chomera chokwanira.

Monga zakudya za mapuloteni, nyama ya nkhuku, nkhuku, kanyumba tchizi, mkaka wopanda mafuta ndizoyenera.

Muyenera kudya masamba ambiri, zipatso, zitsamba, timadziti watsopano. Pewani kudya zakudya zamafuta, zokazinga komanso zosuta. Pewani mowa, kudya mwachangu ndi koloko.

Mutha kuphika pogwiritsa ntchito chowiritsa chowirikiza, pophika, kuwira. Ndikofunika kuti musagwiritse ntchito mafuta, zonunkhira ndi zonunkhira zotentha pophika.

Kutsatira malamulo azakudya makamaka kumatsimikizira kupambana kwamankhwala.

Ndi mankhwala ati omwe ali bwino?

Chifukwa chake, pobwerera ku fanizo la Rosuvastatin, ziyenera kunenedwa kuti mwina m'malo mwa mankhwalawo anali oyamba. Ndipo komabe, ndibwino - choyambirira kapena chofanana? Ndizosatheka kuyankha funsoli, chifukwa pali malingaliro osiyanasiyana a akatswiri pankhaniyi.

Ena amakhulupirira kuti mankhwalawa anali "oyera" ndipo samayambitsa zotsatira zosafunikira. Kuphatikiza apo, madotolo ena amawona luso lapamwamba kwambiri kuposa loyambirira.

Chifukwa chake, adotolo atha kutsogoleredwa ndi malingaliro osiyanasiyana, kufotokozera wodwalayo njira zoyambirira ndi matchulidwe ake.

Ndemanga mwatsatanetsatane wa odziwika bwino komanso otsika mtengo a mankhwala "Rosuvastatin"

Rosuvastatin ndi amodzi mwa mankhwala othandiza kuchepetsa matenda a lipid. Ngati, pazifukwa zingapo, mwachitsanzo, kusowa kwa mankhwala am'deralo kapena mtengo wokwera, wodwalayo sangathe kugula mankhwalawo, ndiye kuti m'malo mwake mungagulitsidwe ndi analogue yotsika mtengo kwambiri, yomwe pali Rosuvastatin yambiri.

Zambiri pazamankhwala ndi malangizo ogwiritsira ntchito

Rosuvastatin (Rosuvastatin) - Ichi ndi mankhwala a lipid-otsitsa a m'badwo wotsiriza wa IV (watsopano) kuchokera ku gulu lochulukirapo lama pharmacological la ma statins, chophatikizira chomwe chiri mankhwala omwe amapezeka ndi dzina lomwelo rosuvastatin mu mawonekedwe a calcium salt (calcium rosuvastatin).

Mankhwalawa adakonzedwa kuti apangitse cholesterol yayitali (hypercholesterolemia) yosatha, yomwe singagwiritsidwe ntchito ndi mankhwala osagwiritsa ntchito mankhwala. Amadziwikanso monga gawo la zovuta za mitundu ina ya mkodzo wamafuta (dyslipidemia), kupewa matenda osokoneza bongo komanso kuchotsa kwa kusintha kwa atherosselotic pamakoma amitsempha yamagazi.

Kuchita kwa ma statins kumakhazikitsidwa ndikuletsa kwa enzyme, yomwe imayang'anira kupanga cholesterol ndi chiwindi (gwero la pafupifupi 80% ya chinthucho).

Njira yamachitidwe Rosuvastatin imakhala yoletsa enzyme - HMG-CoA reductase, yomwe ndi "progenitor" wa endo native synthesis wa cholesterol (Chol, cholesterol) m'chiwindi. Chifukwa cha izi, kuchuluka kwa ma receptor omwe amadzaza ndi otsika kwambiri lipoprotein kumawonjezera, komwe kumapangitsa kuti thupi lawo liziwuka komanso lizichoka m'thupi.

Zotsatira zake, motsutsana ndi momwe ntchito mankhwalawo imagwiritsidwira ntchito, pamakhala kuchepa kwa cholesterol "yoipa" (LDL, LDL), komanso kuchuluka kwa cholesterol "chabwino" (HDL, HDL) m'mwazi kumawonjezera kulipirira.

Mankhwalawa amapezeka mu mawonekedwe a mapiritsi okhala ndi filimu, omwe amayenera kumwa okha mkati (pakamwa), ndi madzi osachepera 100-150 ml, nthawi iliyonse masana, mosasamala chakudya.

Kuphatikizika koyambirira kwa Rosuvastatin kumaphatikizapo shuga ya mkaka (lactose) monohydrate, kupezeka kwake komwe kumapangitsa kuti mankhwala asadziwike kwa odwala omwe ali ndi vuto limodzi ndi anthu omwe ali ndi vuto lactase.

Malangizo Rosuvastatin amasankhidwa ndi dokotala mosamalitsa, kutengera kuzunzika konseko. Kulandila kumayamba ndi mlingo wocheperako (5-10 mg kamodzi patsiku) ndikuwonjezereka ngati pakufunika (malinga ngati palibe zoyipa).

A lipid-kutsitsa kwenikweni kutha kuwonedwa pambuyo 79 patatha masiku chiyambi cha mankhwala, ndipo pambuyo 2-2 milungu ukufika 90-100% ya pazotheka zotheka, amene amasungidwa mu nthawi yonse ya wokhazikika kudya Rosuvastatin.

Ndani wopanga bwino?

Mankhwala oyamba a Rosuvastatin adapangidwa ndi kampani yaku Japan Shionogi & Co (Shionogi & Co), komabe, mayendedwe ake amapangidwa pansi pa dzina lopanda mgwirizano wapadziko lonse (INN) ndi makampani ena opanga mankhwala:

• Russian - Pharmstandard (Phstandard), Ozone (Ozon), Canonfarma (Kanonfarma), FI Obolenskoye (OBL Pharm),
• wakunja - Astra Zeneca (Astra Zeneca), Gideon Richter (Gedeon Richter), Actavis (Actavis), Belupo (Belupo).

Makampani onsewa amatulutsa zamagetsi, i.e., kukopera mankhwala, omwe amagwiritsidwa ntchito omwe ali omwewo rosuvastatin, koma amasiyana ndi kukula koyambirira kwa mzere waukadaulo wopangira, dzina lamalonda ndi kuchuluka kwa opeza.

Popeza kuyimilira mwachindunji kotereku kumagwirizana kwathunthu ndi koyambirira, pakuwona momwe zimagwirira ntchito, zilibe kanthu kuti ndi kampani yanji yomwe ikanakonda kugula, koma mutaganizira kuti Rosuvastatin imatengedwa kwa nthawi yayitali, ndizomveka kulabadira mankhwala otsika mtengo a kunyumba.

Ma analogi odziwika kwambiri ndi kuloweza kwa rosuvastatin

Tisanalingalire za mtundu wa Rosuvastatin mwachindunji, ndikofunikira kudziwa kuti, ngakhale atasankhidwa ndi dokotala, wodwalayo ali ndi ufulu wosankha mtundu woyenera, poganizira zomwe amakonda, chikwama ndi kusalolera payekha pazinthu zina. Chachikulu ndikutsatira mlingo womwe waperekedwa.

Roxera ali ndi zokutira zolimba makamaka, zomwe zimapangitsa kuti rosuvastatin amasulidwe yekha m'matumbo aang'ono, momwe mapiritsiwo amawamwetsa osasinthika, ndipo samayikidwa pakuwonongeka kwa madzi a m'mimba.

Zomwe zimapangidwira: butyl methacrylate ndi methylryacoplate patolymers zowonjezeredwa ndi chigobacho.

Kampani yopanga: KRKA, Slovenia.

Mtengo wa mankhwala: kuchokera 383 RUB / 30 ma PC 5 mg mpaka 1617 ma ruble / 90 ma PC. 20 mg aliyense.

Rosucard (Rozucard) amadziwika ndi bioavailability wabwino (20%), koma yogwira mankhwala rosuvastatin amachotsedwa msanga mthupi, chifukwa chake mankhwalawo ali ndi tanthauzo loti achire.

Zomwe zimapangidwira: m'malo mwa hypromellose pamapangidwe oyambira, croscarmellose imagwiritsidwa ntchito ngati ufa wophika.

Kampani yopanga: Zentiva, Czech Republic.

Mtengo wa mankhwala: kuyambira 613 rub. / 30 ma PC. 10 mg mpaka 2708 ma ruble / 90 ma PC. 40 mg aliyense.

Madokotala amalimbikitsa

Kuti muchepetse cholesterol moyenera komanso kupewa atherosulinosis popanda mavuto, akatswiri amalimbikitsa kuti pakhaleol. Mankhwala amakono:

• kutengera ndi amaranth ogwiritsidwa ntchito pochiza matenda amtima,
• amalimbikitsa kupanga "cholesterol" wabwino, ndikuchepetsa kupanga "koyipa" ndi chiwindi,
• Amachepetsa kwambiri vuto la kugunda kwa mtima ndi sitiroko,
• imayamba kuchita pakatha mphindi 10, zotsatira zake zimakhala zowonekera pambuyo pa masabata atatu.

Kuchita bwino kumatsimikiziridwa ndi machitidwe azachipatala ndi kafukufuku wa Research Institute of Therapy.

Mertenil (Mertenil) ali ndi chiyero chambiri choyeretsa chomwe chimagwira. Izi zimathandizira kulolerana kwa mankhwalawa ndi zovuta zochepa, zomwe ndizofunikira kwambiri mukamamwa rosuvastatin odwala okalamba.

Zomwe zimapangidwira: imagwirizana ndi choyambirira, kupatula pazinthu zomwe zimagwiritsidwa ntchito kupaka utoto.

Kampani yopanga: Gedeon Richter, Hungary.

Mitengo muma pharmacies: kuchokera 478 rub. / 30 ma PC. 5 mg mpaka 1439 ma ruble / 30 ma PC. 40 mg aliyense.

Rosulip (Rosulip) ndi analogue wotsika mtengo wa Rosuvastatin, yemwe ali ndi bioavailability wambiri ndipo amadziunjikira pang'onopang'ono, zomwe zimakuthandizani kuti pang'onopang'ono mupange chidziwitso chofunikira chazogwiritsa ntchito m'thupi.

Zomwe zimapangidwira: ili ndi rosuvastatin osati mwa calcium, koma munthawi ya mchere wa zinc (rosuvastatin zinc).

Kampani yopanga: EGIS (EGIS Pharmaceuticals PLC), Hungary.

Mtengo wa mankhwala: kuchokera 469 RUB / 28 ma PC 5 mg mpaka 1087 rubles / 28 ma PC. 20 mg aliyense.

Crestor (Crestor) - mankhwala okhawo oyambira rosuvastatin. Mankhwala omwe atengedwawo amadziwika ndi kukonzanso kwapamwamba kwambiri kwa chinthu chogwira ntchito ndipo, ngati mumadalira mayankho a wodwala, kulolera bwino, koma pamtengo ndi wokwera mtengo kwambiri kuposa ma genetic ena.

Zomwe zimapangidwira: Zosakaniza zonse ndizofanana ndi chokhalira choyambirira.

Kampani yopanga: Astra Zeneca, United Kingdom.

Mitengo muma pharmacies: kuyambira 1756 rub. / 28 ma PC. 5 mg iliyonse mpaka 5036 rub./28 ma PC. 40 mg aliyense.

Tevastor ndi imodzi mwazifanizo zabwino za Rosuvastatin, chifukwa zimadziunjikira mwachangu m'thupi, kutulutsa mankhwala, ndipo nthawi yomweyo imakhala yotsika mtengo kwambiri kuposa mankhwala oyambirirawo.

Zomwe zimapangidwira: pafupifupi lenten yofanana ndi yoyambayo (kupatula utoto).

Kampani yopanga: TEVA (TEVA Pharmaceutical Industries Ltd), Israel.

Mtengo wa mankhwala: kuchokera 341 rub. / 30 ma PC. 5 mg mpaka 1522 rubles / 90 ma PC. 20 mg aliyense.

Rosuvastatin-SZ

Rosuvastatin-SZ (Rosuvastatin-SZ) - lero ndiwotsika mtengo kwambiri ku Rosuvastatin kuchokera ku wopanga waku Russia. Ngakhale mtengo wotsika kwambiri, siwotsika mtengo kuposa mitundu yonse komanso ulinso ndi zofanana ndi zoyambirira.

Zomwe zimapangidwira.

Kampani yopanga: FC Severnaya Zvezda ZAO, Russia

Mtengo wa mankhwala: kuchokera 178 rub. / 30pcs. 5 mg mpaka 684 rubles / 30 ma PC. 40 mg aliyense.

Kuphatikiza pa ma statins, palinso njira zina. Owerenga amalimbikitsa mankhwala achilengedwe, omwe, kuphatikizapo zakudya komanso ntchito, amachepetsa kwambiri mafuta m'thupi pambuyo masabata 3-4. Maganizo a madotolo >>

Rosart (Rosart) ali ndi zabwino zonse zamankhwala oyambira ndipo samakhala ndi vuto lililonse mthupi, chifukwa zinthu zonse zomwe zimagwira ndi zothandiza zimatsukidwa bwino. Titha kunena kuti ichi ndi cholowa m'malo mwa rosuvastatin.

Zomwe zimapangidwira: zosakaniza zonse ndizofanana pakukonzekera koyambirira.

Kampani yopanga: Gulu la Actavis, Iceland

Mitengo muma pharmacies: kuyambira 426 RUB / 30 ma PC 5 mg mpaka 2347 rub./90 ma PC. 40 mg aliyense.
Zinthu zomwe zimachepetsa cholesterol ndikuyeretsa m'mitsempha yamagazi.

Mankhwala onse othandiza kwambiri a cholesterol mwanjira ya mapiritsi.

Mitundu yotsika mtengo komanso yolowa m'malo mwa mtanda wa ana ndi akulu

Mankhwala Krestor ndi mankhwala ochepetsa mphamvu ya lipid omwe ali m'gulu la akatswiri.

Chithandizo chophatikizika ndi rosuvastatin, chomwe chimatsitsa cholesterol yonse, kuthetsa kusokonekera kwa endothelial kumayambiriro kwa atherosulinosis, kumathandizira magawo amitsempha yamagazi, boma la atheroma, ndi zochitika za magazi. Zotsatira za antioxidant ndi antiproliferative pamthupi zimadziwika.

Zizindikiro zogwiritsidwa ntchito zimaphatikizapo mkhalidwe wa hypercholesterolemia, kuphatikizira homozygous. Contraindication wa mankhwalawa ndi awa: kutenga pakati, kuyamwa, ubwana ndi unyamata mpaka zaka 18, matenda a chiwindi, matenda a impso mu gawo logwira.

Mankhwala omwe amapangidwa ku UK ndi ku Puerto Rico ali ndi malo ena ofananira. Mitengo ya mapiritsi a Krestor sapezeka kwa wodwala aliyense: 800-9800 rubles. Zofananira zotsika mtengo za mankhwalawa zimapangidwa ndi onse opanga omwe akukonza pakhomo komanso akunja.

Analogi opanga Russian

M'malo mwa Ukraine

Momwe mungasinthire mtanda wodutsa, ngati mukufuna kusankha njira yotsika mtengo? Mankhwala oyenerera achi Ukraine akuphatikizanso mndandanda womwe uli pansipa.

• Klivas. Analogue yotsika mtengo ya mtanda mwanjira yam'mapiritsi. Kuphatikizika kwa mankhwalawa kumaphatikizapo rosuvastatin. Mankhwalawa amagwira bwino matenda a hypercholesterolemia, komanso amagwiritsidwa ntchito popewa matenda amtima. Mtengo wapakati ndi 10-55 ma ruble.
• Atorvacor. Atorvastatin kapangidwe kake ka mankhwala amachititsa lipid-kutsitsa, kuchepetsa plasma cholesterol. Malo ogwiritsira ntchito mankhwalawa ndi maselo a chiwindi, motero, pakati pa zotsutsana kwambiri ndikulephera kwa chiwindi. Mtengo wapakati ndi ma ruble 140-220.

Zojambula zaku Belarusi

Ma Belarusian opangidwa ndi mtanda wa Belarus ndi malo oyenera obwezeretsa mankhwala otsika a lipid okhala ndi deta yomweyo malangizo omwe angagwiritsidwe ntchito.

Tebulo likuwonetsedwa pansipa:

Zofanizira zina zakunja

Maimidwe amakono amasulidwe a mtanda wozikidwa pa rosuvastatin:

• Mertenil. Zomwe zimagwira ndi rosuvastatin. Zizindikiro za mankhwala omwe amapezeka ndi dyslipidemic zinthu kuti muchepetse cholesterol. Dziko loyambira - Hungary. Mtengo wapakati ndi ma ruble 510-1700.
• Rosistark. Mankhwala othandizira kunja omwe amachokera ku rosuvastatin pamtengo wotsika mtengo. Ndikulimbikitsidwa kuti muwerenge malangizo ogwiritsira ntchito contraindication, zoyipa ndi zovuta zina zomwe zimafunikira chidwi mukamalandira mankhwala. Mtengo wapakati ndi ma ruble 250-790.
• Tevastor. Yofanana tanthauzo la mankhwalawa amafunsidwa ndi njira yofanana yochitira zinthu. Mankhwalawa amatengedwa kwa nthawi yayitali - njira yokhazikika yochizira imawonedwa pakatha masabata anayi atayamba kumwa. Dziko lomwe adachokera ndi Israeli. Mtengo wapakati ndi ma ruble a 350-1500.
• Roxer. Wothandizira kutsitsa lipid wokhala ndi chigawo chogwira ntchito chofanana ndi mtanda. Mankhwalawa amaletsedwa panthawi yoyembekezera, yoyamwitsa, ana ochepera zaka 18. Kutulutsidwa kwa Chithandizo cha Chislovenia. Mtengo wapakati ndi ma ruble 440-1800.
• Rosulip. Mapiritsi okhala ndi rosuvastatin pakupanga amachepetsa kuchuluka kwa cholesterol m'magazi am'magazi. Kugwiritsa ntchito mankhwalawa ndikofunikira kwa hypercholesterolemia, hypertriglyceridemia, homozygous cholowa hypercholesterolemia, kuti tiletse kukula kwa atherossteosis, komanso kupewa matenda a mtima. Mtengo wapakati ndi ma ruble 380-990.

Chonde dziwani kuti, ma analogu a mankhwala amatha kukhala ndi mphamvu zosiyanasiyana zochizira thupi la wodwala aliyense. Mu malangizo ogwiritsira ntchito, kusintha kosiyanasiyana komwe kumachitika ndi zotsutsana kungasonyezedwe. Dokotala amatha kukupatsani mankhwala ochepetsa lipid.

Mankhwala othandizira amatha kubweretsa chizungulire, chifukwa chake simuyenera kuchita nawo zinthu zina zomwe zimafunikira kuti anthu ambiri azikhala ndi chidwi.

Malangizo a Crestor

MALANGIZO
ntchito zamankhwala
CRESTOR

Zotsatira za pharmacological
Crestor ndi othandizira kutsitsa lipid. Chithandizo chophatikizika cha mankhwalawa ndi rosuvastatin - mpikisano wosankha wa HMG-CoA reductase, enzyme yomwe imatembenuza 3-hydroxy 3-methylglutaryl coenzyme A kupita kwa oyambira cholesterol - mevalonate. Komwe ntchito ya rosuvastatin ndi chiwindi, pomwe pali mphamvu ya otsika kachulukidwe lipoproteins (LDL) ndi mapangidwe cholesterol (cholesterol). Rosuvastatin imakulitsa kuchuluka kwa hepatic receptors kwa otsika kachulukidwe lipoproteins pamitsempha yama cell, zomwe zimapangitsa kuti chiwonjezeke cha satana komanso kutenga kwa lipoproteins yotsika kwambiri komanso kuletsa mapangidwe a lipoproteins ochepa kwambiri (VLDL). Zotsatira zake, pali kuchepa kwa zomwe zili lipoproteins yotsika kwambiri komanso yotsika kwambiri mu seramu.
Rosuvastatin amachepetsa kukwera kwa cholesterol yathunthu, triglycerides ndi LDL cholesterol, apolipoprotein B (ApoV), cholesterol ya VLDL, cholesterol yopanda HDL, cholesterol ya VLDL, cholesterol yonse ya LDL / LLL Ine. Rosuvastatin imakulitsa pang'ono za HDL cholesterol ndi ApoA-I (apolipoprotein A-I).
Kuchuluka kwa Krestor kumayamba pambuyo pa masiku 21 ovomerezeka ndipo kumakhala kosalekeza. Pambuyo masiku 7 atamwa mankhwalawa, njira yothandizira Krestor imawonedwa, ndipo pakatha masiku 14 a kumwa mankhwalawa, kugwiritsa ntchito mankhwalawa ndi 90% ya momwe mungathere.
Mankhwalawa amalembera achikulire omwe ali ndi hypertriglyceridemia kapena hypercholesterolemia, mosaganizira zaka, jenda kapena mtundu. Mankhwalawa angagwiritsidwenso ntchito kwa odwala omwe ali ndi mabanja hypercholesterolemia kapena matenda a shuga.
Ndikumatenga Krestor mu mlingo wa 10 mg mu 80% ya odwala omwe ali ndi mulingo woyambira wa LDL cholesterol wa 4.8 mmol / L (hypercholesterolemia IIa ndi mitundu), kuchepa kwa cholesterol ya LDL kufika ≤3 mmol / L kumawonedwa.Odwala omwe ali ndi mabanja a hypercholesterolemia omwe amalandira mankhwalawa pamtunda wa 20-80 mg, kusintha kwabwino pa lipid kumawonedwa (kafukufuku wamankhwala adachitika ndi kutenga kwa 435 odwala).
Kutsika kwa cholesterol ya LDL ndi 53% kumawonedwa ndi 12-milungu Crestor mankhwala atatha kupereka gawo la 40 mg / tsiku, ndipo LDL cholesterol milingo ya ≤3 mmol / L idakwaniritsidwa mu 33% ya odwala. Odwala omwe ali ndi vuto la homozygous hypercholesterolemia, mankhwalawa adayikidwa pa mlingo wa 20 ndi 40 mg, ndipo motsutsana ndi maziko a chithandizo cha Krestor, kuchepa kwa cholesterol ya LDL inali 22%.
Akaphatikizidwa ndi fenofibrate, zotsatira zowonjezera (mulingo wa triglyceride) zidalembetsedwa, zomwe zimawonedwanso ndikuphatikizidwa ndi nicotinic acid (ponena za cholesterol ya HDL).
Ngakhale palibe deta yoyesa kuchepetsa kuchuluka kwa zovuta zoyambitsidwa ndi vuto la lipid mbiri (mwachitsanzo, matenda a mtima), mayesero azachipatala akupitilizabe.
Pazitali kwambiri pazogwira magazi m'madzi am'magazi zimawonedwa pafupifupi maola 5 mutatha kugwiritsa ntchito Krestor. Bioavailability pafupifupi 20%. Amakhala m'chiwindi. Kuchuluka kwa magawo a rosuvastatin ndi malita 134. Pafupifupi 90% ya mlingo wothandizidwa umamangidwa ndi mapuloteni a plasma (albumin).
Pafupifupi 10% ya mlingo wa rosuvastatin umakhala wochepa kagayidwe. Rosuvastatin ndi chinthu chosakhala pachimake cha kagayidwe kamene amachitika ndi cytochrome P450 system. Enzyme yayikulu yomwe imapanga rosuvastatin ndi CYP 2C9. Pocheperapo, ma enzymes CYP 3A4, CYP 2C19 ndi CYP 2D6 akukhudzidwa ndi metabolism ya rosuvastatin. Ma metabolites ofunikira a lactone metabolites ndi N-dismethyl. Poyerekeza iwo, zidapezeka kuti N-dismethyl ndi pafupifupi theka (50%) yogwira kwambiri kuposa rosuvastatin. Zatsimikizika kuti lactone metabolites ndi yogwira mankhwala.
Kuvomerezeka kwa geometric ya rosuvastatin pafupifupi 50 l / h ndi kuphatikiza kosinthika kwa 21.7 %.Pafupifupi 90% ya mlingo wothandizidwa umachotsedwa osasinthika ndi matumbo ndi ndowe, onse osagwiritsidwa ntchito ndi rosuvastatin komanso odziwitsidwa amachotsedwa. 10% ya chinthucho imachotsedwa ndi impso. Hafu ya moyo pafupifupi maola 19, omwe nthawi zonse amakhala ndi kuchuluka kwa mankhwalawa. Pakukonzekera kwa hepatic kukhudzidwa kwa molekyulu yogwira ntchito (monga zina za HMG-CoA reductase inhibitors), cholesterol transporter imakhudzidwa, yomwe imagwira ntchito yofunika kwambiri pakuchotsa rosuvastatin ndi chiwindi.
Dongosolo kuwonekera kwa rosuvastatin ukuwonjezeka molingana ndi mlingo kutumikiridwa. Pankhani ya kumwa Mlingo wa mankhwala tsiku lililonse, mapiritsi a Krestor omwe amagwira ntchito samasintha.
Kafukufuku woyerekeza wa odwala omwe akukhala ku Asia (mpikisano waku Asia) adawonetsa kuwonjezeka kwa AUC ndikuwonjezereka kwa kuchuluka kwambiri kwa rosuvastatin ndi nthawi 2, poyerekeza ndi deta ya azungu omwe akukhala ku Europe ndi Asia. Mphamvu ya zinthu zachilengedwe komanso ma genetic pazotsatira zomwe zimapezeka mu pharmacokinetic magawo sizinadziwike. Palibe kusiyana kwakukulu mwachipatala komwe kunapezeka pakati pa odwala a Negroid ndi Caucasoid mu pharmacokinetics a rosuvastatin.
Panthawi ya kuwonongeka kwa impso (mapapo kapena sing'anga), zomwe plasma zili ndi rosuvastatin ndi metabolite yake yogwira (N-dismethyl) sasintha kwambiri. Kulephera kwakukulu kwa aimpso ndi creatinine chilolezo cha ≤30 ml / mphindi, plasma ndende yogwira ntchito imachulukitsa katatu (ndipo metabolite yogwira, N-dismethyl, imawonjezera nthawi 9). Plasma ndende ya rosuvastatin odwala kulandira hemodialysis pafupifupi 50% wamkulu. Kafukufuku wa magawo a pharmacokinetic a rosuvastatin mwa odwala omwe ali ndi matenda a impso adachitika poyerekeza ndi gulu la odzipereka athanzi.
Panalibe kuwonjezeka kwa magawo theka la moyo wogwira ntchito mwa odwala omwe ali ndi madigiri osiyanasiyana a vuto la chiwindi, omwe amawunikidwa pamlingo wa Mwana-Pugh wa 7 kapena zochepa mfundo. Odwala ovomerezeka 8 ndi 9 pamawonekedwe a Child-Pugh adawonetsa kuwonjezeka kwa theka la moyo ndi nthawi zosachepera ziwiri. Palibe zokuchitikazi ndi kugwiritsa ntchito rosuvastatin kwa odwala omwe ali ndi hepatic osakwanira omwe ali ndi Mwana-Pugh muyezo wa 9 kapena kupitirira.

Zizindikiro zogwiritsidwa ntchito
· Therapy ya atherosulinosis kuti muchepetse kupitiliza kwa matenda mwa omwe akuwonetsa lipid-kuchepetsa mankhwala,
Pankhani ya homozygous Famer hypercholesterolemia monga kuwonjezera kwa mankhwala ena ochepetsa mafuta m'thupi (mwachitsanzo, LDL-apheresis) kapena zakudya, komanso ngati chithandizo sichikuyenda bwino,
Kuphatikiza pa zakudya - zosakanikirana za hypercholesterolemia (mtundu wa IIB) pamene njira zosagwiritsa ntchito mankhwala (kuchepa thupi, zolimbitsa thupi) komanso kusintha kwa zakudya sizikuyenda,
Mtundu woyamba IIa hypercholesterolemia (kuphatikiza banja heterozygous hypercholesterolemia).

Njira yogwiritsira ntchito
Mankhwalawa amagwiritsidwa ntchito pakamwa, kutsukidwa ndi madzi, nthawi iliyonse masana, osasamala chakudyacho. Osabera.
Mlingo wa Krestor umasankhidwa malinga ndi momwe mankhwalawo amathandizira komanso chifukwa cha kugwiritsa ntchito rosuvstatin, pomwe malingaliro pazogwirizana ndi milomo ya lipoprotein ayenera kukumbukiridwa. Mankhwala ndi odwala, wodwalayo amapatsidwa zakudya zochepetsa lipid (muyezo) kuti azigwiritsika ntchito mosalekeza.
Pankhani yakugwiritsanso ntchito reductase ina ya HMG-CoA kapena kusankhidwa k Koror koyamba, mulingo woyambira wa 5-10 mg / tsiku tikulimbikitsidwa. Kusankha kwa mlingo kumadalira zizindikiro za cholesterol, chiopsezo cha mavuto komanso zinthu zomwe zingayambitse mavuto amtsogolo. Ndi osakwanira kwenikweni, mutha kuwonjezera kuchuluka kwa Krestor pasanadutse masiku 21 chiyambireni mankhwalawa (popeza achire kwambiri amayamba panthawiyi). Kutenga Krestor pa mlingo wa 40 mg kumayambitsa chiwopsezo cha zotsatira zoyipa za mankhwalawa poyerekeza ndi Mlingo wocheperako, kotero kuchuluka kwa Krestor mpaka 40 mg / tsiku kumangololedwa kokha ndi chiopsezo chokhala ndi zovuta zamtima (kuphatikizapo odwala omwe ali ndi hypercholesterolemia) hypercholesterolemia. Kuchulukitsa kwa 40 mg / tsiku kumachitika pokhapokha ngati kufunika kwa kugwiritsa ntchito Crestor pa 20 mg / tsiku sikunachitike, pomwe wodwala amayenera kuyang'aniridwa ndi achipatala. Makamaka chidwi ndi wodwala chotere ndikofunikira m'masiku oyamba kumwa Krestor pa 40 mg / tsiku.
Kuchulukitsa kwa mankhwalawa ndikofunikira pakakhala vuto losafunikira mukatenga mlingo wa 20 mg komanso pansi poti odwala azitha kuyang'aniridwa ndi katswiri. Kuwongolera kwapadera kumalimbikitsidwa kumayambiriro kwa kumwa 40 mg ya mankhwalawa.
Odwala omwe ali ndi mbiri ya geriatric safuna kusintha kwa mlingo.
Ndi kulephera kwa aimpso
Odwala omwe ali ndi digirii yofatsa safuna kusintha kwa mlingo. Kwa odwala omwe amalephera kupezeka aimpso, muyeso wa rosuvastatin uyenera kukhala 5 mg / tsiku.
Mlingo wokwanira tsiku ndi tsiku wolephera kupweteka kwa aimpso ndi 40 mg / tsiku, kulephera kwapakati pamitsempha (ndi creatinine chilolezo cha ≤60 ml / min) - 20 mg / tsiku.
Poika Krestor amatsutsana mu odwala omwe amalephera kwambiri aimpso.
Ndi chiwindi kulephera
Palibe chochitika chogwiritsa ntchito Krestor mwa odwala omwe ali ndi hepatic insuffrehensive omwe adayesedwa pa Childe-Pugh mphambu 9 kapena kuposa. Kukhazikitsidwa kwa Krestor kwa odwala omwe ali ndi matenda a chiwindi mu gawo logwira kumatsutsana.
Mitundu
Kuwonjezeka kwachilengedwe kwa rosuvastatin kumaonekera mwa odwala amtundu wa Mongoloid. Odwala otere ayenera kuyamba kulandira chithandizo cha mankhwala ndi 5 mg / tsiku, ndi mlingo waukulu wa 20 mg / tsiku. Kusankhidwa kwa Krestor kwa odwala a mtundu wa Mongoloid pamtunda wa 40 mg / tsiku kumatsutsana.
Ndi chizolowezi chokhala ndi myopathy
Odwala omwe ali ndi chizolowezi cha myopathy, poyambira mlingo wa rosuvastatin ayenera kukhala 5 mg / tsiku, pazipita mlingo - 20 mg / tsiku. Kukhazikitsidwa kwa mlingo wa Crestor pa 40 mg / tsiku kumatsutsana mwa odwala.
Zotsatira zoyipa
Kukula kwa zoyipa, monga zina za HMG-CoA reductase inhibitors, zimatengera mlingo womwe umagwiritsidwa ntchito.
Zomwe zimayambitsa zovuta zimayesedwa motere: zotsatira zoyipa pafupipafupi (≥1 / 100, ≤1 / 10), zotsatira zoyipa (≥1 / 1000, ≤1 / 100), zotsatira zoyipa (≥1 / 10,000, ≤1 / 1000), zotsatira zoyipa kwambiri (≤1 / 10,000). Zotsatira zoyipa mukamagwiritsa ntchito Krestor zimavoteledwa monga momwe zimafotokozedwera ndikuyimilira pazokha. Kutsiliza kwa mankhwala kwa Krestor panthawi ya mayeso azachipatala chifukwa cha kupezeka kwa zotsatira zoyipa kunali 4% kapena kuchepera.
Kuchokera ku dongosolo lamanjenje: chizungulire, kupweteka mutu (pafupipafupi).
Kuchokera kumbali ya chitetezo chathupi: matupi awo sagwirizana (kuphatikizapo angioedema) - kawirikawiri.
Pa khungu ndi zophatikizika: zotupa, kuyabwa, urticaria (zotsatira zoyipa).
Kuchokera ku minculoskeletal system: rhabdomyolysis ndi myopathy (kawirikawiri), kupweteka kwa minofu (nthawi zambiri). Myopathy, kupweteka kwa minofu, ndi (kawirikawiri) rhabdomyolysis adazindikirika mwa odwala omwe amatenga mlingo uliwonse wa Crestor, koma makamaka kwa iwo omwe amagwiritsa ntchito mlingo wa 20 mg / tsiku. Kukula kodzidalira kwa mlingo wa creatine phosphokinase (CPK), wowona odwala omwe adatenga Krestor, nthawi zambiri sanafotokozedwe, osakhalitsa komanso opanda zizindikiro. Pankhani yowonjezera kuchuluka kwa CPK nthawi 5 kapena kuposerapo, rosuvastatin imayimitsidwa.
Kuchokera m'mimba thirakiti: kudzimbidwa, kupweteka pamimba, nseru (kawirikawiri), kapamba (kawirikawiri).
Kuchokera kwamikodzo dongosolo: tubular proteinuria. Panali kusintha kwa kuchuluka kwa mapuloteni mu mkodzo pang'onopang'ono kuchokera pomwe kunalibe mapuloteni kapena mpaka ma pluses awiri kapena kupitilira kwa ≤1% ya odwala omwe adalembedwa mlingo wa Crestor 10-20 mg / tsiku. Mukamamwa mlingo wa 40 mg / tsiku, chiwerengero cha odwala chotere chinali pafupifupi 3% ya odwala. Mukamagwiritsa ntchito mlingo wa Krestor wa 20 mg / tsiku, kuwonjezeka pang'ono mu kuchuluka kwa mapuloteni mumkodzo kunawonedwa. Proteinuria nthawi zambiri amachepetsa kapena kutha ndikugwiritsidwa ntchito mopitilira ndipo sizinali chizindikiro cha kukula kwa matenda a impso kapena kupitirira kwa omwe alipo.
Kuchokera ku chiwindi: mu odwala ochepa, kuwonjezeka kwa kuchuluka kwa transaminase kumawonekera, monga zina za HMG-CoA reductase inhibitors. Kuchulukitsidwa kwa ma transaminases nthawi zambiri kunali kosakhalitsa, popanda zizindikiro komanso kochepa.
Ena: asthenia (nthawi zambiri).
Pambuyo pofalitsa kufalikira kwa Krestor mu zamankhwala, zotsatirapo zotsatirazi zidalembedwanso:
Kuchokera ku minofu:
Kuchokera ku dongosolo lamanjenje: polyneuropathy (chosowa kwambiri).
Kuchokera ku hepatobiliary system: hepatitis ndi jaundice (chosowa kwambiri).

Contraindication
Matenda a chiwindi omwe akugwira ntchito, kuphatikizapo kuwonjezereka kwa kuchuluka kwa ma transaminase osadziwika, komanso kuwonjezereka kwa transaminase ndi mulingo 3 katatu kapena kupitirira kuposa malire apamwamba.
Zowonongeka zazing'onoting'ono zowonongeka ndi creatinine chilolezo ≤30 ml / min,
Kugwiritsa ntchito munthawi yomweyo cyclosporine,
Pa mimba ndi mkaka wa m`mawere,
Hypersensitivity ya chitetezo chamthupi kupita ku rosuvastatin kapena gawo lililonse la Crestor,
· Mankhwalawa sanalembedwe kwa odwala omwe sagwiritsa ntchito njira zothandiza kwambiri za kulera,
Myopathy
· Mlingo wa Crestor pa 40 mg / tsiku utayikidwa kwa odwala omwe ali ndi chiopsezo cha rhabdomyolysis kapena myopathy.
· Zaka mpaka 18.

Mimba
Mtanda umaphatikizidwa kuti mugwiritse ntchito amayi apakati. Pankhani yoika mayi woyamwitsa, kuyamwitsa kuyimitsidwa. Asanalandire chithandizo ndi Krestor mwa akazi a msinkhu wobereka, ndikofunikira kuyesa mayeso. Ngakhale mukumwa mankhwalawa, ndikofunikira kugwiritsa ntchito njira zoyenera zakulera.

Kuyanjana kwa mankhwala osokoneza bongo
Pogwiritsa ntchito munthawi yomweyo cyclosporine ndi rosuvastatin, AUC yotsirizirayi inali yokulirapo pafupifupi kasanu ndi kawiri kuposa gawo lomweli mwa odzipereka athanzi. Kugwiritsa ntchito munthawi yomweyo mankhwalawa sikusintha plasma ndende ya cyclosporine.
Kumayambiriro kwa chithandizo komanso pakuwonjezeka kwa mlingo wa Crestor, odwala omwe amalandila warfarin ndi othandizira ena a vitamini K nthawi yomweyo, monganso ena a HMG-Co-A reductase inhibitors, akhoza kukumana ndi kuwonjezeka kwa INR - International Normalized Ratio - prothrombin. Kuletsa kwa Krestor kapena kuchepetsa kwake kumapangitsa kuchepa kwa INR. Mukaphatikiza Crestor ndi otsutsana ndi vitamini K, kuyang'anira INR (nthawi ya prothrombin) ndikulimbikitsidwa.
Kugwiritsa ntchito munthawi yomweyo mankhwala osokoneza bongo a lipid (mwachitsanzo, hemifibrozil) ndi rosuvastatin kumapangitsa kuchuluka kwa plasma ndende ya rosuvastatin ndikuwonjezera AUC yake maulendo awiri.
Kugwiritsa ntchito nthawi yomweyo kwa ezetimibe ndi Krestor sikunapangitse kusintha kwa kuchuluka kwa plasma ya mankhwalawa komanso AUC. Komabe, sikulimbikitsidwa kupatula kuyanjana kwawo ndi pharmacological ndikupanga zovuta.
Palibe kuyanjana kwa pharmacokinetic ndi ma fibrate komwe amayembekezeredwa, koma pharmacodynamics ndiyotheka kuyanjana. Hemofibrate, gemfibrozil, michere ina ndi milomo yochepetsa lipid ya nicotinic acid (pa mlingo wofanana ndi 1 g / tsiku kapena kuposerapo) amatha kuyambitsa matenda a myopathy pomwe amamwa ndi HMG-CoA reductase inhibitors. Izi zili choncho mwina chifukwa chakuti othandizawa amachititsa kuyambika kwa myopathy akaperekedwa ngati monotherapy. Chifukwa chake, ndi kuphatikiza uku, ndikulimbikitsidwa kuti odwala azikupangira mankhwala a Krestor 5 mg / tsiku.
Mu mayeso a pharmacokinetic mwa odzipereka athanzi, kuphatikiza kwa Crestor komanso kuphatikiza ma proteinase inhibitors awiri (100 mg ritonavor ndi 400 mg lopinavir) adalumikizidwa ndi kuwonjezeka kwapafupifupi 2 kwa AUC kwa Crestor. Pankhaniyi, kuchuluka kwa rosuvastatin kwambiri kumawonjezeka pafupifupi kasanu. Kuchita ndi ma proteinase inhibitors ena sikunaphunzire. Mukamapereka mankhwala a Krestor kwa odwala omwe ali ndi kachilombo ka HIV omwe amamwa ritonavir / lopinavir pamene akugwiritsa ntchito Krestor, chiwopsezo / phindu lake liyenera kuganiziridwa, makamaka pakukula kwa mankhwalawo kapena koyambirira kwa chithandizo.
Kukhazikika kwa nthawi yomweyo kwa erythromycin ndi rosuvastatin kumayambitsa kuchepa kwa AUC ya rosuvastatin ndi 20% komanso kuchuluka kwa plasma ndende ndi 30%. Kuyanjana kofananako kumayamba chifukwa cha kuchuluka kwamatumbo chifukwa chogwiritsa ntchito erythromycin.
Kufunika kwamankhwala pazoyanjana ndi maantacid ndi Krestor sikunaphunzire. Kugwiritsa ntchito munthawi yomweyo maantacid okhala ndi kuphatikizika kwa mankhwala a magnesium hydroxide kapena aluminium ndi rosuvastatin amachititsa kuchepa kwa nthawi yamapazi yama plasma ndi 50%. Ngati maantacid amatengedwa patatha maola 2 rosuvastatin, ndiye kuti izi sizikutchulidwa.
Palibe kuyanjana kwakukulu ndi digoxin komwe kumayembekezera.
Kugwiritsa ntchito nthawi yomweyo kwa rosuvastatin ndi njira zakulera zamkamwa kumawonjezera AUC ya norgestrel ndi AUC ya ethinyl estradiol ndi 34% ndi 26%, motsatana. Chifukwa chake, kuwonjezeka kwa ndende ya plasma kuyenera kuganiziridwanso pamene mukumwa mankhwala oletsa kubereka.Ma paracokinetic magawo omwe amaphatikiza Krestor ndi mankhwala ogwiritsira ntchito mankhwala omwe amapezeka m'mahoni sanaphunzire, koma kulumikizana koteroko sikungathetsedwe. Kuphatikiza kofananako kwa mankhwalawa kumagwiritsidwa ntchito kwambiri panthawi ya mayesero azachipatala - odwala onse amawalekerera.
Zotsatira za kafukufuku pa kuyanjana kwa vivo ndi vitro zikuwonetsa kuti chinthu cha Krestor sichinthu chosokoneza kapena choletsa ma enzyme a cytochrome P450 system. Rosuvastatin ndi gawo lochepa chabe lomwe lingagwiritse ntchito michere iyi. Panalibe kuyanjana kwakukulu pakati pa ketoconazole (choletsa CYP 3A4 ndi CY P 2A6) kapena fluconazole (choletsa CYP 3A4 ndi CYP 2A9) ndi rosuvastatin. Kukhazikitsa pamodzi kwa itraconazole (choletsa CY P3A4) ndi rosuvastatin kumawonjezera AUC yotsirizira ndi 28%, yomwe ilibe tanthauzo la chipatala. Chifukwa chake, kuyanjana komwe kumalumikizidwa ndi metabolism ya cytochrome P450 sikuyembekezeredwa.

Bongo
Ngati mulingo wapatsidwa, mankhwala ena sanakhazikike. Zizindikiro zothandizira ndi chithandizo chothandizira zimagwiritsidwa ntchito. Ngati mulingo wadutsa, ndikofunikira kuwongolera ntchito za chiwindi komanso zomwe zili za creatine phosphoskinase (CPK). Mphamvu ya hemodialysis ndiyokayikitsa.

Kutulutsa Fomu
Mapiritsi a 10, 20, 40 mg. Pali mapiritsi 28 mu chithuza.

Malo osungira
Sungani ku kutentha kosaposa 30 ° C. Pewani kufikira ana. Yoperekedwa ndi mankhwala.

Kupanga
Crestor 10 mg
Yogwira pophika: rosuvastatin 10 mg.

Crestor 20 mg
Yogwira pophika: rosuvastatin 20 mg.
Zinthu zosagwira: lactose monohydrate, microcrystalline cellulose, calcium phosphate, magnesium stearate, crospovidone, glycerol triacetate, hypromellose, iron oxide red (E 172), titanium dioxide, madzi oyeretsedwa.

Crestor 40 mg
Yogwira pophika: rosuvastatin 40 mg.
Zinthu zosagwira: lactose monohydrate, microcrystalline cellulose, calcium phosphate, magnesium stearate, crospovidone, glycerol triacetate, hypromellose, iron oxide red (E 172), titanium dioxide, madzi oyeretsedwa.

Gulu la mankhwala
Mankhwala a mtima
Mankhwala osokoneza bongo

Chithandizo: Rosuvastatin

Zosankha
Pokhala ndi chiopsezo chowonjezereka cha myopathy kapena rhabdomyolysis, ndikofunikira kulingalira kuchuluka kwa mapangidwe a chithandizo ndi chiwopsezo chotheka, odwala otere amayang'aniridwa mosamala ndi madokotala. Zotheka kuti mulingo wa CPK ukukwera kwambiri (nthawi 5 kapena kuposa) ngakhale musanalandire chithandizo, rosuvastatin sayenera kumwa. Kutsimikiza kwa cretin phosphokinase kuwongolera kuthekera kwa rhabdomyolysis kapena myopathy ndikosayenera kuchita pamaso pa zina zomwe zingachitike pakukula kwa CPK kapena pambuyo pakuchita zolimbitsa thupi kwambiri, chifukwa izi zimathandizira kutanthauzira kolakwika kwa zotsatira. Ngati zotsatira zoyambirira za creatine phosphokinase zichulukitsidwa kangapo kapena kuposerapo, kutsimikiza kwa enzyme m'magazi seramu kuyenera kuchitika osapitirira masiku 5 (pazipita - 7). Simuyenera kuyamba kulandira chithandizo ndi Crestor ngati kutsimikizika kwachiwiri kukuwonetsa kukonzekera kwakukulu kwa creatine phosphokinase (5 times more than the maximum maximum of normal).
Crestor, monga zina zoletsa za HMG-CoA reductase, ziyenera kuyikidwa mosamala kwa odwala omwe ali ndi chizolowezi chokhala ndi myopathy / rhabdomyolysis. Zomwe zimayambitsa rhabdomyolysis kapena myopathy zitha kukhala: hypothyroidism, kulephera kwa impso, mikhalidwe yomwe imayambitsa kuchuluka kwa plasma kwa rosuvastatin, uchidakwa, zaka zopitilira 70, kukhalapo kwa matenda amtundu wobadwa nawo m'mabanja kapena mbiri yakale, myotoxicity yomwe imayambitsidwa ndikugwiritsa ntchito ma fiber ena kapena ma MMC-inhibitors Mbiri ya CoA reductase, kugwiritsa ntchito kwamafelemu.
Ngati Krestor adalandira wodwala, ayenera kumamuuza uthenga wovomerezeka kwa dokotala wokhudzana ndi zochitika zonse za kufooka kwa minofu kosafunikira, kupweteka kwa minofu kapena kupsinjika, makamaka ngati akuphatikizidwa ndi malungo. Odwala otere, kutsimikiza kwa digine phosphokinase (CPK) kumafunikira. Kulandilidwa kwa Krestor kuyenera kuyimitsidwa ngati zomwe zili mu CPK zikuchulukirachulukira (nthawi 5 kapena kupitilira apo), kapena ndi kuopsa kwambiri kwa zizindikiro zam'mimba zomwe zimayambitsa kusasinthika kwakanthawi ndi tsiku ngakhale zitakhala kuti zomwe zili ndi a creatine phosphokinase sizikufika pakuwonjezeka kasanu. Ngati zizindikirizo zikazimiririka ndipo zomwe zili mu CPK zibwerera ku kufunika kwake kwakuthupi, lingalirani za kutenganso zina za HMG-CoA reductase kapena Crestor inhibitors mu Mlingo wotsika kuposa woyamba. Wodwala wotere amafunika kumuyang'anira mosamala. Kuwunikira kwamtundu wa CPK pakalibe zizindikiro za rhabdomyolysis kapena myopathy ndikosatheka.
Panalibe zizindikiro zakuwonjezereka kwa mphamvu ya Crestor pa minofu ya mafupa panthawi yoyesedwa ndi chipatala ndi concomitant therapy. Komabe, pali malipoti akuwonjezereka kwa zochitika za myopathy ndi myositis mwa odwala omwe adatenga zina za HMG-CoA reductase zoletsa zomwe zimachokera ku fibrin acid (kuphatikizapo kugwiritsa ntchito mankhwala monga nicotinic acid, gemfibrozil, cyclosporine, inhibitors mapuloteni, azole antifungal mankhwala ndi macrolide mankhwala. Gemfibrozil imawonjezera mwayi wokhala ndi myopathy wophatikiza ndi Crestor ndi ena a HMG-CoA reductase inhibitors. Sikulimbikitsidwa kupereka Krestor ndi gemfibrozil nthawi imodzi. Ndikofunikira kupenda mosamalitsa kuchuluka kwa mapindu omwe angakhalepo ndi zoopsa zomwe zingapezeke pakupereka kuphatikiza kwa niacin, fibrate ndi Crestor.
Makonzedwe oyendetsedwa ndi ma Krestor fibrate mu 40 mg ndi wotsutsana.
Krestor ali osavomerezeka kwa odwala omwe ali ndi vuto lalikulu kwambiri (mwachitsanzo, ndi ochepa hypotension, zoopsa, sepsis, pakachitika zochulukirapo pochita opaleshoni, zotchulidwa za endocrine, metabolic kapena electrolyte, komanso vuto la khunyu losalamulirika, popeza izi zimatha kukhala pangozi rhabdomyolysis / myopathy).
Odwala omwe amatenga rosuvastatin muyezo waukulu (makamaka pa 40 mg / tsiku), pakhala pali tubular proteinuria. Tubular proteinuria inali yochepa kapena yochepa nthawi zambiri. Proteuria iyi sinali umboni wa kukula kwa matenda am impso kapena kupita patsogolo kwa omwe alipo. Odwala omwe amalandila Krestor mu mlingo wa 40 mg / tsiku, amalimbikitsidwa kuwunikira magwiridwe antchito a impso pakulandila Krestor (njira yonse yaumoyo).
Mukamamwa rosuvastatin, makamaka pa Mlingo pafupifupi 20 mg / tsiku, pakhala pali malipoti azotsatira za minofu yamatumbo, monga kupweteka kwa minofu, rhabdomyolysis, kapena myopathy. Komabe, kuphatikiza kwa ezetimibe ndi HMG-CoA reductase inhibitors, rhabdomyolysis imapangidwa mwazovuta kwambiri.
Chitetezo ndikuyenera kugwiritsa ntchito Krestor mwa ana sizinakhazikitsidwe. Mu machitidwe a ana, zinachitikira kugwiritsa ntchito rosulostatin ndizochepa pazowonera (ana osaposa zaka 8 ndi akulu pamaso pa homozygous Famel hypercholesterolemia). Chifukwa chake, sikulimbikitsidwa kugwiritsa ntchito Krestor pochizira ana.

Zonse zimaperekedwa pofuna kudziwa zambiri osati chifukwa chodzipangira nokha kapena kusintha mankhwala.

Mutha kumverera bwino mu nyimbo yanu yanthawi zonse, ndipo mutatha kuyesedwa, phunzirani za hyperlipidemia - kuchuluka kwa cholesterol ndi triglycerides m'magazi.Kudwala kwa asymptomatic kumawonjezera chiopsezo cha zolembedwa za atherosulinotic - oyambitsa matenda a mtima ndi stroko.

Krestor, mankhwala othandiza a m'badwo wotsiriza omwe adapangidwira matenda a lipid metabolism, amathandiza kupewa zotsatira zowopsa.

Kuthekera kwama pharmacological

Crestor ndi lipid-kuchepetsa mankhwala opangidwa kupewetsa komanso kuchiza matenda a atherosulinosis. Rosuvastatin, wopangira wamkulu, ali ndi hypocholesterolemic ndi hypolipidemic.

Krestor ikulepheretsanso kuchepa kwa HMG-CoA, enzyme yomwe imayang'anira kupanga mevalonate, cholesterol precursor. Rosuvastatin amagwira ntchito mu chiwindi - chimodzi mwazinthu zazikulu za chandamale.

Statin imachepetsa kuchuluka kwa lipoproteins ndi kachulukidwe kotsika kwambiri komanso kotsika kwambiri mwa kutsinikiza kaphatikizidwe kake, komanso kupanga HDL yowonjezera pakuyambitsa ndi kutsutsa kwa LDL. Zotsatira zake, mulingo wa cholesterol wathunthu, LDL ndi triglycerides umachepa. Nthawi yomweyo, kugwiritsidwa ntchito kwa HDL kumawonjezeka.

Rosuvastatin ndi othandiza kwa hypercholesterolemia kuphatikiza kapena popanda hypertriglyceridemia, kwa odwala amtundu uliwonse, zaka kapena mtundu.

Zotsatira zakugwiritsira ntchito kwa Krestor, ndikuwunika ndi ndemanga kuchokera kwa ochita kafukufuku, zimawonedwa kumapeto kwa sabata loyamba la maphunzirowa, koma zotsatira zabwino (zopitilira 90%) zimatha kuwonekera pokhapokha masabata 2-4 atagwiritsidwa ntchito nthawi zonse.

Mosiyana ndi ma analogu ena, Krestor amakhala ndi zovuta zochepa pachiwindi. Gwiritsani ntchito limodzi ndi zakudya zochepa za cholesterol ndi mankhwala ena omwe amachepetsa cholesterol.

Kodi madokotala ndi odwala akuganiza chiyani za Crestor

About Krestor, ndemanga za madokotala ndi odwala zimayenderana: mankhwalawa ndi othandizika, olekerera bwino. Madokotala amazindikira umboni waukulu komanso chidziwitso chakuchita bwino kwa rosuvastatin.

Dovgopolov I.K., cardiologist, woyimira masayansi azachipatala Kwa mwezi umodzi kapena iwiri, sindimapereka mankhwala Krestor kapena analogues ake, ngakhale kupewa. Mutha kuyeretsa zombozo ndikuzimasulira ku cholesterol plaque muzaka ziwiri, ndipo izi muzichita mlingo waukulu (40 mg / tsiku).
Ngati bajetiyo ilola, ndi bwino kugula mankhwala oyambawo. Mtundu woyambirira wa rosuvastatin ndi Krestor, zinali kwa iye kuti kuyezetsa kunachitika ndi kuwunika kwa ziwengo zakufa pamatenda amtima. Kwa ma genetic, palibe deta yotere, koma ma analogue oyenerera amafunika kuti awongolere mawonekedwe a lipid, osatero kwenikweni. Ndiyenera kunena kuti ma statins satengedwa kuti muchepetse LDL, koma kuti muchepetse stroko ndi mtima. Mankhwala ochulukitsa moyo ayenera kumwa mosalekeza.

Korolenko V.N., wamisala. Krestor mwachangu amabwezeretsa kagayidwe ka lipid ngakhale pamankhwala ochepa. Mulingo wothandizira wa mankhwala oyambira ndi olimba, pamakhala zotsatira zoyipa zochepa kuposa ma statin ena, chifukwa chake nditha kupereka mankhwala kwa odwala omwe ali ndi matenda monga shuga mellitus kapena hypercholesterolemia. Mtengo wa Krestor, ndizachidziwikire, koma izi ndizokhazo zomwe zingabwezeretse, makamaka chifukwa mankhwalawa sangakhale otsika mtengo.

Marina, Voskresensk. Krestor ndiokwera mtengo maulendo angapo kuposa anzawo, kuti ndisunge ndalama ndiyenera kugula phukusi lalikulu, koma kwa ine sindikuwona njira ina. Ndakhala ndikugwiritsa ntchito statin kwazaka zopitilira chaka chimodzi, kotero nditha kuwonetsetsa kugwira ntchito kwake. Madokotala akusangalala ndi mbiri yanga ya lipid. Amakhulupirira kuti Krestor ndiye mankhwala abwino kwambiri pagululi. Sindimawona mavuto aliwonse.

Oleg, Irkutsk. Matenda a mtima wanga adadabwitsa ndipo adandipangitsa kuti ndilingalire za thanzi langa. Tinapita ku masewera olimbitsa thupi, kuyesa kusiya kusuta. Dotoloyo adatipatsa zakudya ndi Crestor. Ndimamwa miyezi iwiri yokha, sindikudziwa - kuchokera pamapiritsi kapena m'makalasi ndi ophunzitsa, koma cholesterol tsopano yakhala yofanana - 5.8. Sindikufuna kudalira mankhwalawa moyo wanga wonse, chifukwa ndimayesetsa kukhala ndi moyo watsopano.

Mutha kuphunzira za zomwe zaku America zakugwiritsa ntchito Krestor kuchokera pa kanema wa "Miyoyo Yathanzi Anthu".

Cholinga cha mankhwalawa Krestor, omwe mayendedwe ake amadziwika kwambiri muukonde wa mankhwala, ndikofunikira kuti muchepetse cholesterol yamagazi. Zotsatira zochizira ziziwoneka pambuyo pa masiku 7 kuchokera poyambira kukhazikitsa. Sabata yotsatira, mankhwalawa pafupifupi kawiri amachepetsa kuchuluka kwa cholesterol yoopsa. Chifukwa cha zochitika zosiyanasiyana, mankhwala oyamba sangathe kugwiritsidwa ntchito, mwanjira iyi, generic (analog) imagwiritsidwa ntchito.

Chida chachikulu cha othandizira

Musanalembe mankhwala, muyenera kuchita mayeso. Cholinga chake ndikudziwa kuchuluka kwa thupi. Ngati pakufunika thandizo loyenera, imodzi mwamankhwala otsatirawa ikhoza kusintha zomwe zinapangidwa kale:

Wodwala ali ndi mwayi wosankha analogi zotsika mtengo zomwe sizotsika pazisonyezo zawo kwa mankhwala. Tiyenera kukumbukira kuti mulingo ndi nthawi yogwiritsira ntchito imatsimikiziridwa ndi dokotala pamaziko a zidziwitso zamankhwala zomwe zimapezeka. Izi zikuphatikiza kupewa ndi kuchiza matenda a atherosulinosis ndi cholesterol yayikulu yamagazi.

Mlingo wosankhidwa ndi kulondola kwa miyala yamtengo wapatali umathandizira kupeza zotsatira zabwino. Dokotala amayenera kudziwa kuchuluka kwa mankhwalawo mosamala makamaka ngati wodwala wayamba kudwala mwadzidzidzi kapena matenda a mtima. Ngati munthu wapezeka ndi hypercholesterolemia - cholesterol yosinthika m'magazi, ndikofunikira kugwiritsa ntchito njira zovuta zochizira.

Mankhwala enieni ndi zina zomwe zimalowa m'malo mwake nthawi zambiri zimatchulidwa ngati gawo la chakudya. Mwachitsanzo, adotolo adalimbikitsa kuti achepetse thupi. Poterepa, mutha kugwiritsa ntchito mnzake waku Russia. Tikuyankhula za mankhwalawa Martinil, Ariescor ndi Simvastin. Upangiri wofananawo umakhala ndi chifukwa chabwino pamene wodwala wapezeka ndi mtundu woyamba wa matenda ashuga.

Mlingo umasankhidwa kuti kuchepetsa cholesterol sikubweretsa zotsatira zoyipa.

Zokhudza kugwiritsa ntchito mankhwalawa

Matenda a chiwindi ndi impso ndi miyambo yayikulu yomwe iyenera kuganiziridwa kuti ifulumizitse kuchira. Chifukwa chakuti ma analogues ali ndi zinthu zomwe mwanjira inayake zimakhudza maselo a ziwalo za hematopoietic, dokotala amayenera kuwunika zotsatira zake kangapo. Kumbali imodzi, ndikofunikira kusintha ntchito yamitsempha yamagazi posachedwa. Tikamakhala kuti timatsekeka ndi cholesterol plaque, kumakhala kovuta kwambiri kuti magazi azidutsa m'thupi.

Kumbali ina, muyenera kuganizira mphamvu za chiwindi. Ngati zoletsa za njirayi zimawonedwa, tikulimbikitsidwa kusankha mlingo wovomerezeka - osapitirira 25 g ya thunthu masana. Dokotala munthawi yonse ya chithandizo amayang'anira wodwalayo. Kukhala maso koteroko kungakhale kothandiza ngati wodwalayo ali ndi vuto la impso.

Kuwunikira koyambirira sikungathandize kuti kuvulaze. Kutengera ndi zotsatira zomwe zapezedwa, kumapeto kwake kumafotokozeredwa ndikuyenera kugwiritsa ntchito mankhwalawa. Zina mwazinthu zowopsa, madokotala amatha kusiyanitsa zaka za wodwalayo, kupezeka kwa matenda osachiritsika, omwe adagwiritsidwa ntchito kale ndi mankhwala komanso mawonekedwe angapo.

Njira zopewera

Asanayambe maphunziro othandizira, adokotala amafunika kuwunika ngati analogue kapena mankhwala ake oyambawo ali otetezeka kwa wodwala payekha. Sikulimbikitsidwa kuwaika kukhala amayi oyembekezera komanso oyembekezera. Ndikwabwino kuti musankhe ma Krestor omwe ali ndi hypersensitivity, chiwindi chovutitsidwa, ngati wodwalayo ali ndi zaka 18.

Kugwiritsa ntchito analog kapena mankhwala akuluakulu okhala ndi cholesterol sikutetezeka nthawi zonse. Ngakhale adotolo atawona kusamala konse, pali zotheka kukhala ndi mavuto:

• mawonekedwe a shuga
• migraine ndi mutu
• kulumikizana
• kupweteka m'mimba
• kutsegula m'mimba
• kudzimbidwa
• chizungulire
• urticaria
• zotupa ndi kuyabwa
• kupuma movutikira.

Kugwiritsira ntchito mankhwala akuluakulu ndi mawonekedwe ake amaloledwa pokhapokha kukaonana ndi adokotala. Dokotala adzachita mayeso ndikupereka mayeso ofunikira. Kutengera ndi zomwe zapezedwa, kuyezetsa thanzi kumapangidwa. Pambuyo izi, achire mlingo ndi nthawi ya makonzedwe atsimikiza. Wodwala akamakwaniritsa bwino zomwe walimbikitsidwa, adzachira mwachangu.