Glidiab - malangizo a momwe mungasinthire komanso ndalama zake

Piritsi limodzi lili

ntchito yogwira - gliclazide malinga ndi 100% ya zinthu 80 mg,

obwera: lactose monohydrate, microcrystalline cellulose, mbatata wowuma, hypromellose, magnesium stearate, talc, sodium carboxymethyl.

Mapiritsi ndi oyera kapena oyera ndi mtundu wachikasu kapena wowawasa wowoneka bwino, wosalala-wozungulira, wooneka bwino.

Mankhwala

Pharmacokinetics

Mafuta ndi okwera. Pambuyo pakukonzekera kwa pakamwa 80 mg, nthawi yayitali ya ndende ndi maola 4, ndipo kuphatikiza kwakukulu kwa plasma ndi 2.2-8 μg / ml. Kuyankhulana ndi mapuloteni a plasma - 85-97%, voliyumu yogawa - 0,35 l / kg. Mgwirizano wa plasma wofanana umafikiridwa patatha masiku awiri. Kutha kwa theka-moyo ndi maola 8-20. Amapukusidwa mu chiwindi, ndikupanga 8 metabolites. Kuchuluka kwa metabolite yayikulu yomwe imapezeka m'magazi ndi 2-3% ya kuchuluka kwa mankhwala omwe amwedwa, ilibe katundu wa hypoglycemic, koma imakhudza ma microcirculation. Imafukusidwa ndi impso - 70% mu mawonekedwe a metabolites, osakwana 1% osasinthika, ndi matumbo - 12% mu mawonekedwe a metabolites.

Mankhwala

Oral hypoglycemic wothandizira, yemwe amapezeka m'badwo wachiwiri. Zimapangitsa secretion ya insulin ndi kapamba, imakulitsa mphamvu ya insulin-secretory ya glucose komanso kumva kwa zotumphukira zimakhala ku insulin.

Imalimbikitsa ntchito ya intracellular michere - minofu glycogen synthetase. Amachepetsa nthawi kuchokera pakudya mpaka kuyamba kwa insulin. Kubwezeretsanso nsonga zoyambirira za insulin katulutsidwe (mosiyana ndi zotumphukira zina za sulfonylurea, mwachitsanzo, glibenclamide, yomwe imakhudza gawo lachiwonetsero chachiwiri). Kuphatikiza pa kukhudza kagayidwe kazakudya, kumakhudzanso ma microcirculation. Amachepetsa postprandial hyperglycemia, amachepetsa kuphatikiza kwa maselo am'magazi, amachedwetsa kukula kwa parietal thrombosis, amateteza kupatsirana kwamitsempha ndipo amalepheretsa kukula kwa microsrombosis ndi atherosclerosis, kubwezeretsa njira ya pariological parietal fibrinolysis, ndikuwonjezera kuchuluka kwa matenda a mtima. Imachepetsa kukula kwa matenda ashuga retinopathy osagwirizana, ndi matenda ashuga a nephropathy omwe amagwiritsidwa ntchito kwa nthawi yayitali, kuchepa kwakukulu kwa proteinuria kumadziwika. Siziwonjezera kuchuluka kwa kulemera kwa thupi, chifukwa zimakhala ndi chiwonetsero choyambirira cha insulin secretion ndipo sichimayambitsa hyperinsulinemia, zimathandizira kuchepetsa kulemera kwa odwala onenepa kwambiri, kutsatira zakudya zoyenera. Amakhala ndi anti-atherogenic katundu, amachepetsa kuchuluka kwa cholesterol yathunthu m'magazi.

Mlingo ndi makonzedwe

Mkati, pakudya, mlingo woyambirira ndi 40 mg (mapiritsi ½), muyeso wa tsiku ndi tsiku ndi 80 mg (piritsi 1), avareji ya tsiku ndi tsiku ndi 160 mg (mapiritsi 2 mu Mlingo 2, m'mawa ndi madzulo), mlingo waukulu wa tsiku ndi tsiku ndi 320 mg (mapiritsi 4 mu Mlingo 2 wogawanika - m'mawa ndi madzulo). Mlingo umatengera zaka, kuopsa kwa njira ya matenda ashuga, kuchuluka kwa shuga m'magazi pamimba yopanda kanthu komanso maola awiri atatha kudya.

Kusintha kwa mtundu wina uliwonse kumachitika pakatha milungu iwiri. Ngati mankhwalawo adaphonya, ndiye kuti tsiku lotsatira mlingo sayenera kuchuluka.

Okalamba odwala kapena aakulu aimpso kulephera wofatsa mwamphamvu kuzungulira (creatinine chilolezo - 15-80 ml / mphindi), mankhwala zotchulidwa chimodzimodzi.

Contraindication

Hypersensitivity kwa gliclazide kapena othandizira zigawo za mankhwala, komanso zina za sulfonylurea

mtundu 1 shuga

matenda a shuga komanso chikomokere

kwambiri kwa chiwindi ndi / kapena kulephera kwa aimpso

Mankhwala olimbana ndi miconazole

Mimba, kuyamwa

ana ndi achinyamata ochepera zaka 18

Ndi chisamaliro

Okalamba, osakhazikika komanso / kapena osagwiritsidwa ntchito mokwanira, matenda oopsa a mtima (kuphatikizapo mtima wamkati, matenda a m'matumbo), hypothyroidism, adrenal kapena pituitary insuffence, hypopituitarism, aimpso ndi / kapena kulephera kwa chiwindi, kuchuluka kwa glucocorticosteroid , shuga-6-phosphate dehydrogenase akusowa, chithandizo chogwirizana ndi phenylbutazone ndi danazole.

Zotsatira zoyipa

- hypoglycemia (kuphwanya dongosolo lamankhwala komanso chakudya chokwanira)

- mutu, chizungulire, kutopa, njala, thukuta, kufooka kwambiri

- palpitations, arrhythmia, kuchuluka magazi

- kugona, kusowa tulo, kukwiya, kuda nkhawa, kukwiya, kuchepa kwa chidwi, kulephera kulolera komanso kusachedwa kuyankha, kukhumudwa, kusawona bwino

- aphasia, kunjenjemera, paresis, kusokonezeka kwa malingaliro, kumva kuti palibe thandizo,

kulephera kudziletsa, delirium, kukhumudwa

- kupuma kosakhazikika, bradycardia, kuchepa kwa chikumbumtima

- nseru, kusanza, kupweteka kwam'mimba, kudzimbidwa, kutsekula m'mimba (kuvuta kumachepa ndi chakudya)

- kuwonongeka kwa chiwindi (hepatitis, cholestatic jaundice - - kumafuna kugwiritsidwa ntchito kwa mankhwala, kuchuluka kwa “chiwindi” transaminases, zamchere phosphatase)

- chopewera cha mafupa hematopoiesis (magazi m'thupi, thrombocytopenia, leukopenia, granulocytopenia)

- thupi lawo siligwirizana: kuyabwa pakhungu, urticaria, zotupa pakhungu (kuphatikizapo maculopapular ndi bulous), erythema

- zina zoyipa za sulfonylurea zotumphukira: erythropenia, agranulocytosis, hemolytic anemia, pancytopenia, matendawa vasculitis, chiwopsezo cha chiwindi

Zochita zamankhwala osokoneza bongo

Imawonjezera zotsatira za anticoagulants (warfarin); kusintha kwa anticoagulant kungafunike.

Miconazole (wokhala ndi makonzedwe oyenera komanso akagwiritsa ntchito gel osakaniza pakamwa) amakulitsa mphamvu ya hypoglycemic ya mankhwala (hypoglycemia ikhoza kukhala mpaka kukomoka).

Phenylbutazone (kayendedwe kazinthu) amakulitsa mphamvu ya hypoglycemic ya mankhwala (amachoka chifukwa cha mapuloteni a plasma komanso / kapena amachepetsa kuchotsa kwa thupi), kuwongolera kwa glucose ndi kusintha kwa glyclazide ndikofunikira, onse pakukonzekera kwa phenylbutazone komanso atachotsedwa.

Mankhwala okhala ndi Ethanol ndi ethanol omwe amalimbikitsa hypoglycemia, poletsa zovuta zomwe zimachitika, angathandizire kukulitsa kukomoka kwa hypoglycemic.

Ndi makonzedwe a munthawi yomweyo ndi mankhwala ena a hypoglycemic (insulin, acarbose, biguanides), beta-blockers, fluconazole, angiotensin kutembenuza enzyme inhibitors (ACE) (capopril, enalapril), H2-histamine receptor blockers (cytoxidamides, cytaminidamines) ndi mankhwala omwe si a antiidal a cellidal - kuchuluka kwa hypoglycemic ndi chiwopsezo cha hypoglycemia.

Danazole amachititsa matenda ashuga. Akaphatikizidwa ndi gliclazide, ndikofunikira kuyendetsa shuga wamagazi ndikusintha mlingo wa gliclazide, onse munthawi ya danazol ndipo atachotsa.

Chlorpromazine mu Mlingo wambiri (woposa 100 mg / tsiku) amawonjezera shuga m'magazi, akumachepetsa katulutsidwe ka insulin. Ndikofunikira kuyendetsa shuga wamagazi ndikusintha mlingo wa gliclazide, onse munthawi ya makonzedwe a chlorpromazine atachokanso.

Glucocorticosteroids (systemic, intraarticular, nje, rectal management) amalimbikitsa shuga m'magazi ndikuthekera kwa ketoacidosis (kuchepa kwa kulolerana kwa chakudya cha carbohydrate). Ndikofunikira kuyendetsa shuga wamagazi ndikusintha mlingo wa gliclazide, onse munthawi ya makonzedwe a glucocorticosteroids atachoka.

Ritodrin, salbutamol, terbutaline (iv) - kuwonjezera shuga wamagazi. Mphamvu ya shuga yamagazi imalimbikitsa ndipo ngati nifunikira, kusamutsa wodwala kupita ku insulin.

Malangizo apadera

Mukamamwa mankhwalawa, kutsimikizika kosalekeza kwa magazi a glucose ndi glycosylated hemoglobin ndikofunikira.

Kuchita maopaleshoni akuluakulu komanso kuvulala, kuwotcha kwambiri, matenda opatsirana omwe ali ndi febrile syndrome kungafune kutha kwa mankhwalawa a hypoglycemic mankhwala ndi makonzedwe a insulin.

Odwala ayenera kuchenjezedwa za chiwopsezo chowonjezereka cha hypoglycemia ngati atha kumwa mankhwala okhala ndi ethanol ndi ethanol (kuphatikizapo kusintha kwa zochita za disulfiram: kupweteka kwam'mimba, nseru, kusanza, kupweteka mutu), mankhwala osapweteka a antiidal

Kusintha kwa mlingo ndikofunikira pakulimbitsa thupi ndi malingaliro, kusintha kwa zakudya.

Monga lamulo, zizindikiritso za hypoglycemia zimatha mutatha kudya chakudya chamafuta ambiri (mwachitsanzo, shuga), pomwe kugwiritsa ntchito zotsekemera sizithandiza kuthetsa zizindikiro za hypoglycemic. Hypoglycemia imatha kubwereranso ngakhale popuma bwino. Ngati zizindikiro za hypoglycemic ndizachangu kapena zitalizitali, ngakhale pakakhala kusintha kwakanthawi mutatha kudya chakudya chamafuta ambiri, chithandizo chamankhwala chodzidzimu ndikofunikira, mpaka kuchipatala.

Makamaka chidwi ndi machitidwe a mankhwala a hypoglycemic ndi anthu okalamba, odwala omwe salandira chakudya chokwanira, omwe amakhala ofooka kwambiri, odwala omwe ali ndi vuto la kusowa kwa pituitary-adrenal. Mawonetseredwe azachipatala a hypoglycemia amatha kutsekedwa mukatenga beta-blockers, clonidine, reserpine, guanethidine. Kukula kwa kukana kwachiwiri kwa mankhwalawa ndikotheka (kuyenera kusiyanitsidwa ndi koyambirira, komwe mankhwalawo samaperekanso kuyembekezera kachipatala koyamba).

Kupereka mankhwala a sulfonylurea kwa odwala omwe ali ndi vuto la glucose-6-phosphate dehydrogenase (G6PD) kungayambitse kuchepa kwa magazi m'thupi. Chenjezo liyenera kuthandizidwa popereka Glidiab kwa odwala omwe ali ndi vuto la G6PD ndikuwona mwayi womwe ungagwiritsidwe ntchito ndi mtundu wina wa mankhwala.

Kuphatikizika kwa mankhwalawa kumaphatikizapo lactose monohydrate, mogwirizana ndi izi, Glidiab sayenera kugwiritsidwa ntchito mwa odwala omwe ali ndi cholowa cha galactosemia, glucose-galactose malabsorption, ndi kuchepa kwa lactase.

Zomwe zimachitika chifukwa cha mankhwalawa amatha kuyendetsa galimoto kapena njira zoopsa

Munthawi ya chithandizo, chisamaliro chikuyenera kuchitika poyendetsa magalimoto ndi kuchita zina zomwe zingakhale zoopsa zomwe zimafuna kuti anthu azisamalira komanso azithamanga kwambiri.

Bongo

Zizindikiro: hypoglycemia, kusokonezeka kwa chikumbumtima, hypoglycemic chikomokere.

Chithandizo: Ngati wodwalayo akudziwa, kumeza shuga, kuti asadziwike bwino, iv akalandira 40% ya dextrose, ndiye iv 5% dextrose solution drip mpaka magazi a shuga afikire 5.55 mol / l, 1-2 mg glucagon v / m, kuyang'anira kuchuluka kwa shuga m'magazi mphindi 15 zilizonse, komanso kudziwa pH, urea, creatinine ndi ma elekitirodi m'magazi. Pambuyo podziwikanso, ndikofunikira kuti mupatse wodwalayo chakudya chambiri m'zakudya zamafuta ochepa (kuti mupewe kukonzanso kwa hypoglycemia). Ndi matenda edema, mannitol ndi dexamethasone. Kutsegula m'mimba sikothandiza.

Wopanga

AKRIKHIN OJSC, Russian Federation,

142450, dera la Moscow, chigawo cha Noginsky, mzinda wa Staraya Kupavna,

Foni / Fakisi: (495) 702-95-03.

Dzinalo ndi dziko laomwe amalembetsa satifiketi

AKRIKHIN OJSC, Russian Federation,

Adilesi ya bungwe lolandila madandaulo kuchokera kwa ogula pa mtundu wa zinthu (katundu) mdera la Republic of Kazakhstan:

AKRIKHIN OJSC, Russian Federation,

142450, dera la Moscow, chigawo cha Noginsky, mzinda wa Staraya Kupavna,

Kodi Glidiab MV

Pamafunika kuwongolera glycemic popewa zovuta za shuga. Monga lamulo, dongosolo la mankhwalawa limaphatikizanso kukonza kwa zakudya komanso ntchito. Ndi nthenda yachiwiri, njirazi nthawi zambiri sizikhala zokwanira, chifukwa chake pamakhala kufunsa kwa mankhwala ochepetsa shuga. Gawo loyambirira la matendawa limadziwika ndi kukana insulini komanso kuchuluka kwa shuga m'chiwindi, motero panthawiyi mankhwala othandiza kwambiri ndi metformin (mwachitsanzo, Glucofage).

Matenda oopsa a hyperglycemia munthawi yochepa imayambitsa kukanika kwa maselo osokoneza bongo komanso kuwonongeka kwa insulin. Kusintha koteroko kukayamba, ndikofunikira kuwonjezera mapiritsi pazomwe zimaperekedwa kale zomwe zingalimbikitse kupanga kwa insulin. Mwa mankhwala omwe alipo, DPP4 inhibitors, incretin mimetics, ndi sulfonylureas amatha izi.

Magulu awiri oyambawa amagwiritsidwa ntchito posachedwa, ngakhale kuti mankhwalawa ndi othandiza, koma okwera mtengo. M'madera ambiri a Russia, kuwapezera zaulere ndizovuta. Koma zotchipa za sulfonylureas zimatsimikiziridwa kuti zimayikidwa kuchipatala chilichonse. Mankhwala otetezeka kwambiri komanso amakono kwambiri pa mankhwalawa ndi glimepiride (Amaryl) ndi mtundu wosinthika wa glyclazide (Diabeton MV ndi mayendedwe ake, kuphatikiza Glidiab MV)

Diabetes ndi mankhwala oyamba, Glidiab ndi generic wabwino. Kafukufuku watsimikizira zofanana za mankhwalawa pa glycemia.

Malangizo ogwiritsira ntchito amafotokozera zochita zingapo za Glidiab:

1. Kubwezeretsanso gawo loyamba la kupanga insulin, chifukwa chomwe shuga amayamba kusiya ziwiya atangolowa.
2. Kukweza 2 magawo.
3. Kuchepetsa kuphatikiza kwa mapulateleti, kukonza kuthekera kwa mtima wa epithelium kupasuka kwa thrombi. Izi zimachepetsa mwayi wamisempha yamavuto.
4. Kusasinthika kwa ma radicals aulere, kuchuluka kwake kumawonjezeka ndi matenda a shuga.

Pali maphunziro omwe akuwonetsa kuti kukonzekera kwa sulfonylurea kumabweretsa kuwonongeka kwa maselo a beta, kumabweretsa kuchepa kwa insulini ndikukakamiza odwala matenda ashuga kuti asinthe kupita ku insulin. Glidiab m'gulu lake ndi imodzi mwamankhwala otetezeka pankhaniyi. Mlingo wamba wa mankhwalawa umachulukitsa kaphatikizidwe ka hormone ndi 30%, ndipo pomwe amapanga amapita ndi 5% chaka chilichonse. Munjira yachilengedwe matendawa, kusowa kwa insulin kumawonjezeka chaka chilichonse ndi 4%. Ndiye kuti, sizingatheke kuyitanitsa Glidiab kwathunthu chifukwa cha kapamba, komanso sizingafanane ndi mankhwala olimba kuchokera ku gulu lomweli, mwachitsanzo, Maninil.

Zisonyezero zoika mankhwalawa

Malinga ndi malangizo, Glidiab amalembedwa kokha kwa odwala matenda ashuga omwe ali ndi mitundu iwiri ya zovuta za carbohydrate. Mphamvu ya mankhwalawa imayendetsedwa mwachindunji kwa maselo a beta, omwe palibe mtundu 1 wa shuga. Kuchiza kuyenera kuphatikizidwa ndi zakudya komanso masewera olimbitsa thupi, kunenepa kwambiri komanso / kapena kukana insulin, metformin imawonjezeredwa.

Glidiab amangokhala ngati cholumikizira metformin, pokhapokha ngati wodwala akwaniritsa zonse zomwe wapezeka, koma osatha kufikira glycemia. Monga lamulo, izi zikuwonetsa kuchepa kwa gawo la pancreatic ntchito. Kuti muwonetsetse kuchepa kwa insulin ndi kufunikira kwa Glidiab, ndikofunika kuti ayese mayeso a C-peptide.

Kumayambiriro kwa matendawa, mankhwalawa amalembedwa pokhapokha ngati magazi a m'magazi ndi okwera kwambiri, ndipo amakayikira kuti matenda a shuga adapezeka zaka zingapo pambuyo pake momwe adayambira.

Mlingo ndi mawonekedwe

Wopanga amatulutsa Glidiab m'mitundu iwiri:

1. Mlingo wa Glidiab wa 80 mg. Awa ndi mapiritsi achikhalidwe omwe ali ndi gliclazide, zinthu zomwe zimagwira kuchokera kwa iwo zimatengedwa mwachangu m'magazi ndikufika pachimake patatha maola 4. Inali nthawi imeneyi kuti chiopsezo chachikulu kwambiri cha hypoglycemia. Mlingo wapamwamba pa 160 mg umagawidwa mu 2 Mlingo, kotero shuga imatha kutsika pafupipafupi masana.
2. Glidiab MV ndi yamakono kwambiri, mapiritsi amapangidwa mwanjira yoti gliclazide kuchokera kwa iwo imalowa m'magazi pang'ono ndi pang'ono. Izi ndizomwe zimatchedwa kuti kusinthidwa, kapena kupitilira. Chifukwa cha izo, zotsatira za Glidiab zimawonjezeka bwino ndipo kwa nthawi yayitali zimasungidwa chimodzimodzi, zomwe zimawonjezera mphamvu ya mankhwalawa, zimachepetsa muyeso wofunikira, komanso kupewa hypoglycemia.

Kusiyana kwa mtengo pakati pa mankhwalawa ndizochepa - Glidiab MV ndi okwera mtengo kwambiri ndi ma ruble 20, ndipo kusiyana kotetezako ndikofunikira, chifukwa chake wopanga amalimbikitsa kuti odwala matenda ashuga asinthane ndi mankhwala atsopano. Malinga ndi kuthekera kwake, piritsi limodzi la Glidiab 80 ndilofanana ndi piritsi limodzi la Glidiab MV 30.

Mlingo Walimbikitsa:

Lamulo la kuwonjezera kuchuluka kwa mankhwalawa malinga ndi malangizo ogwiritsira ntchito: ngati mlingo woyambira ungakhale wokwanira, utha kuwonjezeredwa ndi 30 mg (80 kwa Glidiab wokhazikika) pakatha mwezi wokhazikitsidwa. Mutha kuwonjezera kuchuluka kwake kwa odwala matenda ashuga okha omwe shuga ya magazi sinasinthe. Kukula msanga kwamankhwala oopsa kumakhala kowopsa ndi chifuwa cha hypoglycemic.

Momwe mungagwiritsire ntchito Glidiab

Glidiab

Glidiab MV

Malinga ndi madokotala, odwala omwe ali ndi matenda osakhazikika samamwa mankhwala onse omwe apatsidwa. Ndi matenda a 2 a shuga, zovuta sizingokhala ndi glucose wambiri, motero odwala amakakamizidwa kumwa ma statins, aspirin, ndi mankhwala othamanga ndi magazi kuphatikiza pa mankhwala ochepetsa shuga. Mankhwala ambiri amakhala ndi mankhwalawo komanso akamathandizira kuchuluka kwa mankhwalawo, amachepetsa mwayi kuti aledzeretsedwe m'njira yoyenera. Glidiab MV amatengedwa kamodzi patsiku, mosasamala za kuchuluka kwa mankhwala, motero, sakonda kuphonya mlingo.

Doctor of Medical Science, Mutu wa Institute of Diabetesology - Tatyana Yakovleva

Ndakhala ndikuphunzira matenda a shuga kwa zaka zambiri. Zimakhala zowopsa anthu ambiri akamwalira, ndipo makamaka amakhala olumala chifukwa cha matenda ashuga.

Ndithamangira kunena mbiri yabwino - Endocrinological Research Center ya Russian Academy of Medical Sayansi yakwanitsa kupanga mankhwala omwe amachiritsa odwala matenda ashuga mellitus. Pakadali pano, kugwiritsa ntchito bwino kwa mankhwalawa kuyandikira 98%.

Nkhani ina yabwino: Unduna wa Zaumoyo wateteza kukhazikitsidwa kwa pulogalamu yapadera yomwe imalipira mtengo wa mankhwalawo. Ku Russia, odwala matenda ashuga mpaka Meyi 18 (kuphatikiza) nditha kuipeza - Kwa ma ruble 147 okha!

Zotsatira zake zoyipa

Mndandanda wazotsatira zoyipa zomwe zimatheka mukamatenga Glidiab MV 30 mg ndi mawonekedwe ake:

1. Hypoglycemia imachitika ndi mankhwala osokoneza bongo, ndikulumphira chakudya kapena kuperewera kwa chakudya m'matimu. Kutsika kofupipafupi kwa shuga kumafunikira kukonzanso kwa zakudya ndi kuchepetsa kwa glidiab.
2. Matenda am'mimba. Kuchepetsa chiopsezo cha mbali iyi, malangizowo akutsimikiza kuti mutenge Glidiab nthawi yomweyo ndi chakudya.
3. Zikopa. Malinga ndi ndemanga, zovuta zina zoyipa sizimachitika.
4. Sinthani muzomwe zili m'magazi. Nthawi zambiri zimasinthidwa, ndiye kuti, zimadzipezeka zokha zitatha kuvomereza.

Kuopsa kwa hypoglycemia akuti pafupifupi 5%, komwe kumatsika kwambiri poyerekeza ndi sulfonylureas yakale. Anthu omwe ali ndi matenda a shuga mellitus osakanikirana ndi matenda oopsa a mtima ndi endocrine, komanso kutenga mahomoni kwa nthawi yayitali, amakonda kutsika shuga. Kwa iwo, muyeso wovomerezeka wa Glidiab ndi wochepa mpaka 30 mg. Anthu odwala matenda ashuga omwe ali ndi vuto la neuropathy, okalamba, odwala omwe amakhala ndi hypoglycemia wokhazikika kapena wa nthawi yayitali, amasiya kumva zizindikiro za shuga wochepa, motero kutenga Glidiab kungakhale koopsa kwa iwo. Pankhaniyi, mapiritsi a shuga omwe alibe zotsatira zoyipa zotere amavomerezeka.

Mafanizo otchuka

Pakati pa mapiritsi a antiidiabetesic pochiza matenda amtundu 2, ndimakonzedwe a glyclazide omwe amagawa kwambiri. Metformin ndi okhawo omwe angapikisane nawo mu kuchuluka kwa mayina olembetsedwa. Mitundu yambiri ya Glidiab imapangidwa ku Russia, mtengo wawo m'mafakitala umasiyana pakati pa ma ruble a 120-150, mtengo wa French Diabeteson wodula kwambiri umakhala pafupifupi ma ruble a 350.

Ma analogi a Glidiab ndi ena:

Glidiab kapena Gliclazide - ndibwino?

Ubwino wa mankhwala umatsimikiziridwa ndi kuchuluka kwa kuyeretsedwa ndi kulondola kwa mulingo wa chinthu chomwe chikugwira, chitetezo cha zigawo zothandizira. Glidiab ndi Glyclazide (kupanga Ozone) ali ofanana mwamitundu iyi. Akrikhin ndi Ozone ali ndi zida zamakono, makampani onsewa sadzipangira okha mankhwala, koma amagula, kuwonjezera apo, kuchokera kwa omwe amapanga aku China omwe. Ndipo kapangidwe kamakomedwe, Glidiab ndi Gliclazide pafupifupi amabwerezananso. Ndemanga za anthu omwe amamwa mankhwalawa kwa chaka chopitilira amatsimikiziranso kuyesayesa kwawo kofanana mu shuga.

Glyclazide ili ndi mitundu iwiri ya kusankha - 30/60 mg, Glidiab - 30 mg yokha, Glidiab imatha kusinthidwa ndikutulutsidwa mwachizolowezi, Gliclazide imangotulutsidwa kokha - ndiwo kusiyana konse pakati pamapiritsi awa.

Njira yamachitidwe ndikuwonetsa ntchito

Glidiab MV ndi wothandizira waogoglycemic wa gulu la sulfonylurea zotumphukira za m'badwo wachiwiri. Mankhwalawa amakhala ndi gliclazide ndi okondwerera. Glyclazide piritsi limodzi lili ndi 80 mg kapena 30 mg.

Kodi chigawo chogwira ntchito cha mankhwalawo chimagwira ntchito bwanji? Glyclazide pa mayamwidwe imalimbikitsa minofu glycogen synthetase ntchito ndi insulin katulutsidwe. Komanso, izi zimapangitsa kuti inshuwaransi ikhale yachinsinsi, komanso imathandizira kuti chiwopsezo cha zotumphukira ziwonongeke.

Kuphatikiza apo, gliclazide imathandizira kuchepetsa kusiyana pakati pa kudya ndi kuyambika kwa gawo lobisika la insulin. Ngati mutayang'ana malangizo omwe mungagwiritse ntchito ku Glidiab, mutha kudziwa kuti mukamagwiritsa ntchito mapiritsi, kuchuluka kwa hyperglycemia kumachepa, ndipo nsonga yoyambirira ya insulin secretion imabwezeretseka.

Zinthu zonsezi zimakhudza kagayidwe kazakudya ndi michere. Ngati mukukhulupirira malangizowo, ndiye kuti Glidiab MV amathandizira kuchepetsa kuphatikizika ndi kuphatikizika kwa mapulateleti, komanso munthawi imodzimodziyo kusintha matenda amitsempha. Mwachidule, pogwiritsa ntchito mapiritsi, mwayi wopita patsogolo kwa micothrombosis ndi atherosulinosis umachepetsedwa kwambiri.

Kafukufuku adawonekeranso kuti wothandizira wa hypoglycemic amathandizira kuchepetsedwa kwa zovuta monga matenda ashuga retinopathy pamalo osapindika. Kuphatikiza apo, kugwiritsa ntchito mapiritsi a Glidiab MV kungakulitse kwambiri mphamvu ya mankhwala othandizira odwala onenepa kwambiri.

Ndikufuna kudziwa kuti ma metabolites a mankhwalawa amachotsedwa pamodzi ndi mkodzo m'njira yosasinthika, komanso palinso ndowe mu mawonekedwe a metabolites.

Malangizo ogwiritsira ntchito mankhwalawa

Ndi munthawi ziti zomwe zikuyenera kugwiritsa ntchito mapiritsi a Glidiab 80? Malangizowo akunena kuti ndikofunikira kugwiritsa ntchito mankhwalawa mankhwalawa mtundu wa 2 matenda a shuga, ngati mankhwala othandizira pakudya ndi masewera olimbitsa thupi samathandizira kukhazikika kwa shuga.

Molumikizana ndi mankhwala ena, Glidiab MB sigwiritsidwa ntchito kwambiri. Koma ziyenera kudziwika kuti zotsatira za hypoglycemic za mankhwalawa zitha kuchuluka ngati, limodzi ndi mankhwala osokoneza bongo, kudya ndikusewera masewera ndizoyenera.

Momwe mungamwere mankhwala? Mlingo woyambirira ndi 80 mg. Komanso, pafupipafupi kugwiritsa ntchito ndi 2 kawiri pa tsiku - m'mawa ndi madzulo. Ndi bwino kumwa mapiritsi 30-60 mphindi musanadye.

Ngati mulingo wocheperako wa 80 mg ulibe hypoglycemic, ndiye kuti mwapang'onopang'ono kuchuluka kwake. Nthawi zambiri, matenda amtundu wa 2 shuga, muyezo wa 160 mg ndi wokwanira. Mlingo woyenera wovomerezeka wa mankhwalawa ndi 320 mg.

Koma tiyenera kukumbukira kuti ndi kuchuluka kwa Mlingo, mwayi wopita patsogolo wa hypoglycemia ndi zovuta zina kumakula kwambiri.

Kuyanjana Ndi Mankhwala Osokoneza Ubwenzi

Kumbukirani kuti mankhwalawa amatha kuonjezera mphamvu ya hypoglycemic ya mankhwala a Glidiab MB. Chifukwa chake, malangizowo amanenanso kuti mankhwalawa amayenera kuphatikizidwa mosamala kwambiri ndi histamine H2-receptor blockers, mankhwala osapatsa mankhwala a antiidal, othandizira antifungal, ACE inhibitors.

Mankhwala ochepetsa chifuwa, ma beta-adrenoblockers, anticoagulants osadziwika, anabolic steroids, Mao inhibitors, salicylates ndi ena amathanso kukulitsa zotsatira za hypoglycemic.

Ndiye chifukwa chake, musanagwiritse ntchito mapiritsi a Glidiab, muyenera kuphunzira mosamala malangizo ndikuyang'ana dokotala.

Mwa contraindication kugwiritsa ntchito mapiritsi angadziwike:

1. Matenda a shuga a Mtundu woyamba amadalira insulin.
2. Matenda a shuga ketoacidosis.
3. Zabwino kapena zaphokoso. Kuphatikiza apo, kutsutsana kokhwima ndi hyperosmolar coma.
4. Leukopenia
5. Nthawi yapakati.
6. Nthawi yonyamula.
7. Kulephera kwakukulu kwa hepatic ndi aimpso.
8. Mikhalidwe yomwe imayendetsedwa ndi kuphwanya njira ya mayamwidwe akudya, komanso kukula kwa hypoglycemia. Zinthu zoterezi zimaphatikizira matumbo, kutsekeka kwa m'mimba komanso matenda opatsirana.
9. Chiwopsezo kwa zigawo za mapiritsi.
10. Mikhalidwe yomwe insulin mankhwala ingafunikire. Izi zimaphatikizapo kupsa, kuvulala, kapena opaleshoni.
11. Mowa
12. Febrile syndrome.

Komanso, mankhwalawa ayenera kugwiritsidwa ntchito mosamala kwa anthu omwe ali ndi vuto la chithokomiro.

Ndemanga ndi zoyipa za Glidiab

Ndi ndemanga ziti za Glidiab? Anthu odwala matenda ashuga amayankha bwino mankhwalawo. Anthu ambiri amakopeka ndi mtengo wotsika mtengo wa mankhwalawo, komanso mitengo yokwera kwambiri.

Komanso, Gladiab, malinga ndi anthu odwala matenda ashuga, ndiabwino chifukwa samayambitsa zotsatira zoyipa pamankhwala ochepa. Chikhalidwe china cha mankhwalawa kwa anthu ndikuti zimawonjezera mphamvu ya mankhwala othandizira kudya.

Zotsatira zoyipa zomwe mankhwala a hypoglycemic angayambitse? Malinga ndi malangizo, mankhwalawa angayambitse:

• Kuphwanya kwa endocrine dongosolo. Amawoneka ngati hypoglycemia. Koma dziwani kuti kuphatikiza uku kumachitika pokhapokha ngati pali mankhwala osankhidwa bwino.
• Kukwiya, kugona, kuzunzidwa, kunjenjemera miyendo, mutu, chizungulire, kutopa kwambiri.
• Kuchepetsa maonedwe owoneka.
• Aphasia.
• Bradycardia
• Kupuma kosapumira.
• Delirium.
• Thrombocytopenia, kuchepa magazi, leukopenia.
• Thupi lawo siligwirizana.
• Matumbo dongosolo. Munthu amatha kudwala matenda otsekula m'mimba, kumva kupsinjika kwa dera la epigastric, nseru, matenda anorexia, cholestatic jaundice, kuchuluka kwa hepatic transaminases.

Nthawi zambiri, mavuto amadzisinthira atasiya kumwa mankhwalawo ndikulandira chithandizo chamankhwala choyenera.

Analogue yabwino kwambiri ya Glidiab

Kodi ma fanizo a Glidiab ndi ati? M'malo mwake, othandizira osiyanasiyana a hypoglycemic malinga ndi metformin hydrochloride angagwiritsidwe ntchito. Analog yamagulu othandiza kwambiri ndi Fomu. Mankhwalawa ndiye malo abwino kwambiri a Glidiab.

Mtengo wa mankhwalawa ndi pafupifupi ma ruble a 180-260. Fomu imapezeka mu mlingo wa 500 mg, 850 mg ndi 1 gramu. Phukusi limodzi lili ndi mapiritsi 60. Kuphatikizika kwa mankhwalawa kumaphatikizapo metformin hydrochloride, povidone, primellose, magnesium stearate.

Kodi chigawo chogwira ntchito cha formin chimagwira bwanji? Malangizowo akuwonetsa kuti metformin hydrochloride imalepheretsa gluconeogeneis m'chiwindi, komanso amathandizira kuchepetsa kuyamwa kwa glucose kuchokera m'matumbo.

Komanso, gawo lokhazikika limathandizira kugwiritsidwa ntchito kwina kwa glucose, ndikuthandizira kukulitsa chidwi cha minofu pazovuta za insulin. Pankhaniyi, metformin hydrochloride sichikhudza momwe insulin imasungidwira ndi maselo a beta, chifukwa chomwe imapangitsa kuchepa kwa hypoglycemia.

Mothandizidwa ndi Forthin, matenda a shuga a 2 amatha kuthandizidwa. Makamaka, mankhwalawa amagwiritsidwa ntchito ngati wodwala matenda ashuga atha kunenepa kwambiri komanso ngati chithandizo cha zakudya sichithandiza kuteteza matenda a shuga. Ndikufuna kudziwa kuti mankhwalawa nthawi zambiri amagwiritsidwa ntchito molumikizana ndi mankhwala okhudzana ndi sulfonylurea.

Momwe mungapangire formin? Mlingo woyambirira ndi 1000-1700 mg patsiku. Komanso, mulingo womwewo mumagawa 2. Ndikwabwino kugwiritsa ntchito mapiritsi mutatha kudya, kumwa madzi ambiri.

Ngati shuga m'magazi sakhazikika, ndiye kuti mulingo womwewo umakulitsidwa pang'onopang'ono mpaka magalamu 2-3 patsiku. Mulingo wovomerezeka watsiku lililonse wa Formetin ndi magalamu atatu, osapitilira apo. Koma odwala okalamba amalimbikitsidwa kudya zosaposa gramu imodzi patsiku.

Zotsatira zosagwiritsidwa ntchito ndi mankhwalawa:

1. Chiwopsezo kwa zigawo zake.
2. Matenda a impso, makamaka kulephera kwa aimpso.
3. The pachimake gawo la myocardial infarction.
4. Kuthetsa madzi m'thupi.
5. Mtima kapena kulephera kupuma.
6. Cerebrovascular ngozi.
7. Uchidakwa wambiri
8. Mimba komanso kuyamwa.
9. Zomwe zimafunikira pakugwiritsa ntchito insulin. Izi zimatha kuvulaza kwambiri, kuwotcha, kapena kuchita opareshoni.
10. Lactic acidosis.
11. Kutsatira zakudya zamagulu, zomwe zimapereka kuchepa kwa zopatsa za tsiku ndi tsiku kupita ku ma kilocalories a 1000.
12. Ntchito masiku 2 omaliza a x-ray maphunziro ndi kuyambitsa kusiyanasiyana kwa ayodini. Mwa njira, mankhwalawa sayenera kumwa masiku awiri 2 musanakumane ndi X-ray.

Mwa zina zoyipa za mankhwalawa, pali zovuta m'magayidwe am'mimba, kusokonezeka kwa metabolic, kuchepa kwa magazi, kuchepa kwa magazi ndi matendawo. Kanemayo munkhaniyi akuwuzani zamankhwala omwe ali ndi matenda ashuga.