Isulin insulin

Dzina la malonda akukonzekera: Genetic engineering insulin-isophan (Insulin-isophan human biosynthetic)

Dzinalo Losasamala: Insulin + Isofan

Fomu ya Mlingo: kuyimitsidwa kwa makina oyang'anira

Chithandizo: insulin + isophane

Gulu la Pharmacotherapeutic: insulin yochita pakati

Machitidwe

Insulin yochita pakati. Kuchepetsa kuchuluka kwa shuga m'magazi, kuonjezera mayamwidwe ndi minofu, kumapangitsanso lipogenis ndi glycogenogeneis, kaphatikizidwe ka mapuloteni, kumachepetsa kuchuluka kwa shuga ndi chiwindi.

Imalumikizana ndi cholandirira china kumtundu wakunja wamaselo ndikupanga insulini yolandirira. Mwa kuyambitsa kaphatikizidwe ka cAMP (m'maselo amafuta ndi maselo a chiwindi) kapena kulowa mwachindunji mu cell (minofu), insulini yolandirira insulin imapangitsa njira zina, kuphatikizira kaphatikizidwe angapo ofunikira a michere (hexokinase, pyruvate kinase, glycogen synthetase, etc.). Kutsika kwa shuga wamagazi kumachitika chifukwa cha kuchuluka kwa kayendedwe kake ka chidwi, kuchuluka kwa zotupa, kukondoweza kwa lipogenesis, glycogenogeneis, kaphatikizidwe ka mapuloteni, kuchepa kwa kuchuluka kwa kupanga kwa shuga ndi chiwindi (kuchepa kwa kuphwanya glycogen), ndi zina zambiri.

Pambuyo pa jekeseni wa sc, matendawa amapezeka maola 1-1.5. Kuchuluka kwake kumachitika pakatikati pa maola 4-12, kutalika kwa nthawi ndi maola 11-24, kutengera kapangidwe ka insulin ndi mlingo, kumawonetsa kupatuka kwakapakati komanso mkati mwa munthu.

Zisonyezero zogwiritsidwa ntchito:

Mtundu woyamba wa shuga.

Type 2 shuga mellitus, gawo la kukana mankhwalawa a hypoglycemic, kutsutsana kwapakamwa kwa mankhwala a hypoglycemic (kuphatikiza mankhwala), matenda oyanjana, chithandizo cha opaleshoni (mono- kapena chithandizo chamankhwala), matenda a shuga nthawi yayitali.

Zoyipa:

Hypersensitivity, hypoglycemia, insulinoma.

Mlingo ndi makonzedwe:

P / C, katatu patsiku, mphindi 30-45 musanadye kadzutsa (sinthani malo a jekeseni nthawi iliyonse). Mwapadera, adokotala amatha kukupatsani jakisoni wa / m mankhwala. Mu / pakubweretsa insulin ya sing'anga nthawi yoletsedwa! Mlingo amasankhidwa payekha ndipo zimatengera zomwe zili ndi shuga m'magazi ndi mkodzo, mawonekedwe a matendawa. Nthawi zambiri, Mlingo ndi 8-24 IU 1 nthawi patsiku. Akuluakulu ndi ana omwe ali ndi chidwi chachikulu ndi insulin, mlingo wochepera 8 IU / tsiku ukhoza kukhala wokwanira, mwa odwala omwe ali ndi chidwi chokwanira - oposa 24 IU / tsiku. Pa mlingo wa tsiku lililonse wopitilira 0,6 IU / kg, - wofanana ndi jakisoni 2 m'malo osiyanasiyana. Odwala omwe amalandila 100 IU kapena kuposerapo patsiku, akachotsa insulin, ndikofunika kuchipatala. Kusamutsa kuchokera ku mankhwala kupita ku wina kuyenera kuchitika mothandizidwa ndi shuga wamagazi.

Zotsatira zoyipa:

Ndi kuphwanya kwa dosing regimen, zakudya, kulimbitsa thupi, matenda amtundu, hypoglycemia ikhoza kukhala, m'malo ovuta kwambiri, komanso chikhalidwe chonyansa.

Mwina: thupi lawo siligwirizana, m`deralo - redness ndi kuyabwa, ambiri - anaphylactoid zimachitikira.

Mogwirizana ndi mankhwala ena:

Mankhwala osagwirizana ndi mayankho a mankhwala ena. Mphamvu ya hypoglycemic imapangidwira ndi sulfonamides (kuphatikizapo mankhwala a hypoglycemic, sulfonamides), ma inhibitors a MAO (kuphatikizapo furazolidone, procarbazine, selegiline), carbonic anhydrase inhibitors, ACE inhibitors, NSAIDs (kuphatikizapo salicylates), anabolic (kuphatikiza stanozolol, oxandrolone, methandrostenolone), androgens, bromocriptine, tetracyclines, clofibrate, ketoconazole, mebendazole, theophylline, cyclophosphamide, phenfluramine, Li + kukonzekera, pyridoxine, quinidine, quinine, etloroquin, etloro. Zotsatira Hypoglycemic wa kulemala glucagon, kukula timadzi, corticosteroids m'kamwa kulera, estrogens, thiazide ndi kuzungulira okodzetsa, mahomoni BCCI, chithokomiro, heparin, sulfinpyrazone, sympathomimetics, danazol, tricyclics, clonidine, calcium muzikangana, diazoxide, morphine, chamba, fodya, phenytoin, epinephrine, H1-histamine receptor blockers.

Beta-blockers, reserpine, octreotide, pentamidine imatha kuwongolera ndi kufooketsa mphamvu ya hypoglycemic ya insulin.

Zoyenera kusunga:

Mu firiji, kutentha kwa 2-8 ° C (musazizire). Pewani kufikira ana.

Tsiku lotha ntchito: Zaka 2

Osagwiritsa ntchito tsiku lotha ntchito likusonyezedwa pa phukusi.

Zoyenera kufalitsa kuchokera ku malo ogulitsa mankhwala: Ndi mankhwala

Wopanga: ICN Jugoslavija, Yugoslavia