Vipidia 25 mg

Vipidia (mapiritsi) Kutalika: 177

Wopanga: Ikufotokozedwa
Kutulutsa Mafomu:

• Tab. 12,5 mg, 28 ma PC., Mtengo kuchokera ku ma ruble 973
• Tab. 25 mg, 28 ma PC., Mtengo kuchokera ku ma ruble a 1282

Mitengo ya Vipidia m'mafakitoreti apulogalamu
Malangizo ogwiritsira ntchito

Vipidia ndi othandizira a hypoglycemic pamapiritsi okhala ndi alogliptin. Amapereka kuchepa kwa glycosylated hemoglobin ndi glucose. Amasonyezedwa ngati pali mtundu wa shuga wachiwiri wa mtundu wa 2 mellitus mu mawonekedwe a monotherapy, komanso kuphatikiza mankhwala ndi ena othandizira a hypoglycemic. Mlingo woyenera ndi 25 mg / tsiku, amatengedwa mosasamala chakudya. Wolemba matenda ashuga ketoacidosis, mtundu 1 shuga mellitus, mtima kulephera, aimpso ndi chiwindi kulephera. Zotsatira zoyipa zingaphatikizepo kupweteka kwa mutu, kupweteka kwa epigastrium, zotupa, matenda opatsirana a ziwalo za ENT. Ana ochepera zaka 18 ndi amayi apakati samayikidwa chifukwa chosowa chidziwitso pazomwe zimachitika.

Mndandanda wa mankhwala Vipidia

Analogue ndiotsika mtengo kuchokera ku ma ruble 863.

Wopanga: Merck Sante SAA.S. (France)
Kutulutsa Mafomu:

• Mapiritsi 500 mg, 30 ma PC., Mtengo kuchokera ku ma ruble 110
• Mapiritsi 1000 mg, 30 ma PC., Mtengo kuchokera ku ma ruble 185

Mitengo ya Glucophage m'mafakitale opezeka pa intaneti
Malangizo ogwiritsira ntchito

French mankhwala zochizira mtundu 2 shuga. Kugulitsidwa pamapiritsi okhala ndi 500 mpaka 1000 mg ya metformin monga chokhacho chophatikiza. Pali zotsutsana, motero, musanatenge Glucofage, ndikofunikira kufunsa katswiri.

Analogue ndiyotsika mtengo kuchokera ku ma ruble 182.

Wopanga: Novartis (Switzerland)
Kutulutsa Mafomu:

• Mapiritsi 50 mg, 28 ma PC., Mtengo kuchokera ku 791 rubles
• Mapiritsi 1000 mg, 30 ma PC., Mtengo kuchokera ku ma ruble 185

Mitengo ya Galvus m'masitolo ogulitsa pa intaneti
Malangizo ogwiritsira ntchito

Galvus ndi piritsi lokonzekera mankhwalawa a mtundu 2 a shuga omwe amachokera ku vildagliptin mu mlingo wa 50 mg. Itha kuthandizidwa monga monotherapy komanso ngati gawo limodzi la mankhwala othandizira pakakhala zovuta kudya komanso kuchita masewera olimbitsa thupi.

Analogue ndiotsika mtengo kuchokera ku ma ruble 795.

Wopanga: Hemofarm A.D. (Serbia)
Kutulutsa Mafomu:

• Tab. 500 mg, 60 ma PC., Mtengo kuchokera 178 ma ruble
• Mapiritsi 1000 mg, 30 ma PC., Mtengo kuchokera ku ma ruble 185

Mitengo ya Metformin muma pharmacistine apamtaneti
Malangizo ogwiritsira ntchito

Metformin ndi mankhwala achi Serbia hypoglycemic ogwiritsira ntchito mkati. Kuphatikizika kwa mapiritsi kumakhala ndi chophatikizira cha dzina lomweli muyezo wa 500 kapena 850 mg. Amalembera mankhwalawa mtundu wa matenda ashuga 2 (achikulire), makamaka ngati ali ndi kunenepa kwambiri.

Analogue ndiokwera mtengo kwambiri kuchokera ku ma ruble 799.

Wopanga: Bristol Myers squibb (USA)
Kutulutsa Mafomu:

• Mapiritsi a 5 mg, ma PC 30., Mtengo kuchokera ku 1772 rubles
• Mapiritsi 1000 mg, 30 ma PC., Mtengo kuchokera ku ma ruble 185

Mitengo ya Onglisa m'mafakitale opezeka pa intaneti
Malangizo ogwiritsira ntchito

Onglisa ndi mankhwala aku America pochiza matenda a shuga 2 omwe amachokera pa saxagliptin mu gawo la 2,5 kapena 5 mg. Amawonjezera kuwonjezera pa zolimbitsa thupi ndi zakudya kuti azitha kusintha glycemic control.

Analogue ndiokwera mtengo kwambiri kuchokera ku ma ruble a 1236.

Wopanga: Merck Sharp ndi Dome (USA)
Kutulutsa Mafomu:

• Mapiritsi 100 mg, 28 ma PC., Mtengo kuchokera ku ma 900 rubles
• Mapiritsi 1000 mg, 30 ma PC., Mtengo kuchokera ku ma ruble 185

Mitengo ya Januvia muma drug online
Malangizo ogwiritsira ntchito

Januvia ndi mankhwala ku America a matenda ashuga. Zogwira pophika: sitagliptin (mwanjira ya phosphate monohydrate) 100 mg. Itha kugwiritsidwa ntchito ngati kuwonjezera pa zolimbitsa thupi ndi zakudya kuti muchepetse shuga.

Analogue ndiokwera mtengo kwambiri kuchokera ku ma ruble 675.

Wopanga: Beringer Ingelheim (Austria)
Kutulutsa Mafomu:

• Mapiritsi a 5 mg, ma PC 30., Mtengo kuchokera ku ma ruble 1648
• Mapiritsi 1000 mg, 30 ma PC., Mtengo kuchokera ku ma ruble 185

Mitengo ya Trazhenta muma pharmacin opezeka pa intaneti
Malangizo ogwiritsira ntchito

Trazhenta - mankhwala a ku Austria opangidwa pochiza matenda a shuga 2, angathe kuikidwa onse ngati mankhwala osokoneza bongo. Chokhacho chokhacho chophatikizidwa ndi linagliptin mu mlingo wa 5 mg. Trazenta sinafotokozeredwe mtundu woyamba wa matenda ashuga, pa nthawi yoyembekezera, mkaka wa m'mawere, komanso mwa ana osakwana zaka 18.

Kutulutsa mawonekedwe, kapangidwe kake ndi ma CD

Mankhwala amapangidwa mwa mawonekedwe a mapiritsi ozungulira omwe amaphatikizidwa ndi nembanemba wamafilimu. Mlingo:

• 12,5 mg - mapiritsi achikasu
• 25 mg - tint yofiirira.

Chogulitsachi chimagulitsidwa m'makatoni. Kuyika: matumba 4, okhala ndi mapiritsi 7, zidutswa 28 za paketi yonse.

Chithandizo chogwira mankhwalawa ndi alogliptin. Zinthu Zothandiza:

• magnesium wakuba,
• sodium croscarmellose,
• cellcrystalline mapadi,
• Hyprolose

Makanema ophatikizira piritsi amatanthauza:

• hypopellose,
• Utoto wa oxide wachitsulo
• titanium dioxide
• macrogol
• inki imvi F1

Zochita zamankhwala

Alogliptin ndi dipeptidyl peptidase-4 inhibitor yosankha kwambiri. DPP-4 ndiye puloteni yayikulu yomwe imayambitsa kusokonekera mwachangu kwa mahomoni a banja la ma impretin. Makamaka, ndi glucose-insulinotropic polypeptide (HIP) yokhala ndi glucagon-peptide-1 (GLP-1). Ma mahomoni amenewa amapangidwa m'matumbo, ndipo msinkhu wake umasiyanasiyana kutengera ndi chakudya chomwe mumadya. Zotsatira za HIP ndi GLP-1 zimayambitsa kukhazikitsa kaphatikizidwe ka insulin mwachindunji mu kapamba.

Glucagon-ngati peptide imathandizira kuchepetsa kuchuluka kwa glucagon ndikuchepetsa kupanga glucose m'chiwindi. Kusintha kulikonse kwa kuchuluka kwa ma insretins motsogozedwa ndi alogliptin, kupanga kwa insulin kumawonjezera ndipo glucagon amachepetsa ndi shuga wowonjezereka. Mwa anthu omwe ali ndi matenda ashuga, kusintha kotereku kumapangitsa kuti glycosylated hemoglobin komanso magawo ena amkati asanadye komanso pambuyo pake.

Pharmacokinetics

Mankhwalawa amathandizanso munthu wathanzi komanso wodwala matenda ashuga. Alogliptin amalowetsedwa m'thupi ndi pafupifupi 100%, mosasamala kanthu za chakudya chomwe chimadyedwa. Ndi piritsi limodzi, chinthu chogwira chimalowa mwachangu m'magazi, pomwe maola 1 mpaka 2 amwe mankhwalawa amapezeka.

Alogliptin imakonda kugawidwa bwino mu minofu. Ubwenzi ndi mapuloteni a plasma pafupifupi 20-30%. Ndi kugwiritsa ntchito mankhwalawa kwa nthawi yayitali, kudzikundikira kwa chinthu chamoyo m'thupi, malinga ndi kuchuluka kwa manambala, sikuwoneka mwa anthu athanzi kapena odwala. Pakupita maola 21 mutamwa mankhwalawa, 70% ya mankhwala amapezeka ndi impso m'malo osasinthika, 13% ndi matumbo.

Vipidia imalembedwa mtundu wa shuga. Chidacho chimathandizira odwala, ngakhale osagwirizana ndi zakudya komanso kusowa kochita zolimbitsa thupi. Mankhwala angagwiritsidwe ntchito ngati monotherapy. Mutha kumwa nawo limodzi ndi mankhwala ena omwe amathandizira kuchepetsa kuchuluka kwa shuga m'magazi.

Contraindication

Monga mankhwala aliwonse, Vipidia ili ndi malire ake. Werengani iwo mosamala.

Mankhwala sayenera kumwa ndi:

• Hypersensitivity thupi kwa chilichonse chomwe chiri gawo la mankhwala,
• mtundu 1 shuga
• matenda ashuga ketoacidosis,
• kulephera kwa mtima
• kuvulala kwambiri kwa chiwindi,
• Mimba ndi kuyamwa
• ana ochepera zaka 18.

Musamale:

• kapamba
• kulephera kwapakati pamiyendo,

Malangizo ogwiritsira ntchito (mlingo)

Vipidia amayenera kumwedwa pakumwa asanadye komanso atatha kudya. Ndikulimbikitsidwa kugwiritsa ntchito osaposa 25 mg pa tsiku. Nthawi zina amawapangira limodzi ndi mankhwala ena, monga:

Ndi othandizira a Vipidia okhala ndi metformin kapena thiazolidatedione, mlingo umakhalabe wosasinthika. Kupatula chiopsezo cha hypoglycemia, mankhwala akapatsidwa mankhwala nthawi yomweyo ndi insulin, ndikofunikira kuchepetsa Mlingo wotsatira. Ngati pazifukwa zina mukuyiwala kumwa mankhwalawo, muyenera kukonza mwachangu. Koma nthawi imodzi mlingo wowirikiza suyenera kumwa.

Mlingo wa shuga m'magazi mwachindunji zimatengera zomwe zili alogliptin mthupi. Chifukwa chake, kudumpha mankhwala osavomerezeka sikulimbikitsidwa.

Zotsatira zoyipa

Pali nthawi zina pamene zizindikiro zosasangalatsa zimachitika chifukwa cha mankhwala a Vipidia. Wodwala angadandaule za:

• mutu
• kupuma matenda
• nasopharyngitis,
• kupweteka m'mimba
• kuyabwa ndi zotupa pakhungu,
• chitukuko cha kapamba,
• mapangidwe aimpso kulephera.

Ngati zizindikilo zowopsa ngati izi zizindikiridwa, muyenera kudziwitsa dokotala. Ndi iye yekha amene angasankhe kupitiliza kumwa mankhwalawo kapena ayi. Kuwonetsera kwakukulu kwa zizindikiro zomwe zili pamwambapa kumafuna kusiya mankhwala mwachangu.

Bongo

Kuchulukitsa mwangozi sikuopseza anthu. Kuthandizidwa ndi dokotala kumafunika pokhapokha ngati kuli kosagwirizana ndi Vipidia kapena mukamamwa mankhwala ndi anthu omwe akudwala matenda omwe ali pamndandanda wazotsutsana. Thandizo loyamba la bongo - chapamimba.

Malangizo apadera

Kugwiritsira ntchito kwa Vipidia ndi insulin ndi mankhwala ena omwe amachepetsa shuga ya magazi kumafuna kusintha kwa mankhwalawa kuti mupewe kukula kwa hypoglycemia. Malinga ndi kafukufuku wazachipatala, kulumikizana kwa alogliptin ndi zida zina zamankhwala sikuwonetsa kusintha.

Alogliptin imakhudza thupi kwambiri, kotero panthawi ya chithandizo muyenera kukana kumwa mowa.

Mankhwala "Vipidia" samayambitsa kugona, kotero kuyendetsa galimoto ndi zochitika zina zomwe zimafunikira chidwi chochuluka siziletsedwa.

Chofunikira: Kafukufuku wasonyeza kuti mankhwalawa samakhudza chiwindi kwambiri, akumaphwanya mbali zina zake. Kufikira pomwe pancreatitis yachilendo imatha kuchitika. Chifukwa chake, musanagwiritse ntchito mankhwalawa, ndikofunikira kuyesedwa ndikuyerekeza zabwino ndi zowawa zilizonse.

Chifukwa chosowa zambiri zokhudzana ndi zovuta pamimba komanso mkaka wa m'mawere, ndibwino kuti musamwe Vipidia.

Ana ndi ukalamba

Kupereka mankhwala kwa ana ndi achinyamata osakwana zaka 18 zakubadwa, chifukwa cha kusowa kwazidziwitso zamankhwala pazaka izi.

Odwala a zaka zopitilira 60 amatha kumwa "Vipidiya". Mlingo wanthawi zonse sofunikira kusintha. Komabe, ziyenera kukumbukiridwa kuti kuthekera kwa kuchepa kwa kugwira ntchito kwa impso ndi chiwindi zimatengera kuchuluka kwa alogliptin.

Migwirizano ndi magwiritsidwe akusungidwa

Sungani mankhwalawo pamalo amdima, ozizira kutali ndi ana. Nthawi yogwiritsira ntchito ndi zaka zitatu kuyambira tsiku lomwe adatulutsa. Tsiku lopanga limamangiriridwa kumayikidwe. Mankhwala omwe atha ntchito amaletsedwa.

Mtengo wa Vipidia m'masitolo amasiyana pamitengo ya mankhwalawo komanso dera lomwe mukukhalamo. Pa avareji, ndi 845 - 1390 rubles.

Mankhwalawo sagulitsidwa, amangogulitsidwa kokha ndi mankhwala.

Fananizani ndi fanizo

Ngati pazifukwa zina mankhwalawo sagwirizana ndi wodwalayo, adokotala amafunafuna mankhwala omwe atha kusintha.

Mndandanda wa mankhwala "Vipidia":

Dzinalo	Mapindu ake
Galvus Met	Njira yothandiza yochepetsera shuga. Zimathandizanso kuchotsa mapaundi owonjezera popanda kudya mokakamizidwa.	Mndandanda waukulu wazotsatira zoyipa. Mtengo wokwera wa mankhwalawo.	Kuchokera pa ruble 780.
Alogliptin	Zimathandizira kusintha misinkhu ya shuga. Sizimayambitsa kuchuluka kwa kagayidwe. Sichikundikira, imachotsedwa kwathunthu ku thupi.	Sitha kugwiritsidwa ntchito pa matenda a impso, chiwindi, kapamba. Mankhwala siotsika mtengo.	Kuchokera ku 845 rubles.
Januvia	Chimalimbikitsa kuwonda, amachepetsa kudya, amateteza magawo a magazi.	Mtengo. Imakhala ndi zotsutsana zambiri kuti zigwiritsidwe, chifukwa chake ndikofunikira kuti dokotala akupatseni mankhwala.	Kuyambira 1350 rubles

Mayankho ambiri ochokera kwa odwala matenda ashuga omwe atenga Vipidia ndi abwino. Mapiritsiwa amachepetsa shuga m'magazi, amaloledwa bwino, koma ayenera kugwiritsidwa ntchito pokhapokha ngati akuwuzani dokotala. Anthu sakonda zoti mankhwalawa ndi okwera mtengo. Nawa malingaliro enieni:

Ndinapezeka ndi matenda ashuga zaka 5 zapitazo. Adalembedwa ndi endocrinologist, amamwa mankhwala ambiri. Koma masabata angapo apitawa, shuga adayamba kukwera mpaka 18. Dokotala adandiwuza Vipidia. Ndimamwa piritsi limodzi patsiku, shuga ndi abwinobwino. Ndili wokondwa kwambiri. Inemwini ndinapeza mu mankhwalawa mwayi umodzi wokha.

Vipidia imalowa m'malo mwa insulin bwino kwambiri. Ndipo poyerekeza ndi iyo, mankhwalawo amangofunika kumwa kamodzi patsiku. Sikufunika kusunga zakudya. Ndili ndi matenda ashuga, mapiritsi amatengera kuchuluka kwa shuga m'magazi, chifukwa chake ndidakana kale insulin. Chowonadi chimasokoneza pang'ono pamtengo, mankhwalawa siotsika mtengo, si aliyense angakwanitse kugula. Koma, zoona, pali ma pluses. Ndikupangira izi kwa aliyense.

Ndili ndi matenda ashuga a 2. Analandira chithandizo, adamwa mankhwala tsiku lililonse, koma glucose ndiye amachepetsa, kenaka adakulanso mpaka mayunitsi 12. Panali zochitika za hypoglycemic zimachitika, kutsika kwamphamvu kwa shuga. Dokotala adandiwuza Vipidia. Ndimakondwera kwambiri ndi mankhwalawa. Ndimamwa piritsi limodzi lokha m'mawa ndipo zonse zili bwino. Ngakhale ndizodula, koma sindimawona kusinthasintha kwa magawo a magazi ndikukhazikika tsiku lonse. Ndikupangira izi kwa aliyense.

Adotolo adandipatsa mankhwala oti ndigule mankhwalawa "Vipidia". Ndadwala matenda ashuga kwa zaka zingapo. Ndinkakonda mankhwala, amachepetsa kuwerenga kwa glucose. Ndimamwa kamodzi kokha patsiku. Ilibe zotsutsana mukamacheza ndi mankhwala ena, zomwe ndizosangalatsa kwambiri. Zilibe kukhudzana ndi psyche ndipo sizimayambitsa kugona. Kuyendetsa galimoto ndi iye sikuletsedwa. Ndine wokhutira ndi chilichonse, mankhwala othandiza omwe sanayambitse mavuto ena.

Kutulutsa mafomu ndi kapangidwe kake

Mankhwalawa amapangidwa piritsi la 25 mg la yogwira - alogliptin benzoate. Pakatikati mwa mapiritsiwo mumakhala mankhwala othandizira:

• cellcrystalline mapadi,
• magnesium wakuba,
• mannitol
• sodium croscarmellose,
• hyprolose.

Pamwambapa mapiritsiwo pali mawonekedwe a filimu yopanga hypromellose, titanium dioxide, macrogol 8000, utoto wachikasu womwe umatengera iron oxide. 25 mg mapiritsi ndi ofiira.

Zotsatira za pharmacological

Mankhwala ndi a gulu la hypoglycemic wothandizira chifukwa cha kusankha kuponderezedwa kwa ntchito ya dipeptidyl peptidase-4. DPP-4 ndi puloteni yofunika yophatikizira kuchepa kwapang'onopang'ono kwa kuphatikiza kwa mahomoni a ma insretins - enteroglucagon ndi insulinotropic peptide, yomwe imadalira kuchuluka kwa glucose (HIP).

Mahomoni ochokera ku gulu la ma insretins amapangidwa m'matumbo. Kuphatikizika kwa mankhwala opangira mankhwala kumawonjezeka ndi kudya kwambiri. Glucagon-ngati peptide ndi GUI imakulitsa kaphatikizidwe ka insulini m'malo opezeka pancreatic a Langerhans. Enteroglucagon nthawi imodzi imalepheretsa kuphatikizika kwa glucagon ndipo imalepheretsa gluconeogeneis mu hepatocytes, yomwe imapangitsa plasma ndende ya insretins. Alogliptin imakulitsa katemera wa insulini, kutengera shuga.

Zizindikiro zogwiritsidwa ntchito

Mankhwala amathandizidwa ndi odwala zochizira osagwirizana insulin 2 matenda a shuga ndi matenda a glycemic kulimbana ndi maziko ochepa mphamvu ya zakudya mankhwala ndi zolimbitsa thupi. Kwa odwala akuluakulu, mankhwalawa amatha kutumikiridwa onse monga monotherapy, komanso ngati gawo la chithandizo chovuta ndi Insulin kapena mankhwala ena a hypoglycemic.

Kutenga Vipidia 25?

Mapiritsiwo adapangira pakamwa. Ndi bwino kugwiritsa ntchito mankhwalawa ndi Mlingo wa 25 mg kamodzi patsiku, mosasamala kanthu za kudya. Ma unit a mankhwalawa sangathe kutafunidwa, chifukwa kuwonongeka kwamakina kumachepetsa kuyamwa kwa alogliptin m'matumbo ang'onoang'ono. Osamwa pawiri.Wodwala yemwe wasowa piritsi pazifukwa zilizonse ayenera kumwa mofulumira.

Chithandizo cha matenda ashuga

Othandizira azaumoyo amalimbikitsa kuti mutenge mapiritsi a Vipidia mukatha kudya pamene shuga ya magazi akukwera. Mukamapereka mankhwala ngati chida chowonjezera chothandizira ndi Metmorphine kapena Thiazolidinedione, palibe chifukwa chosinthira mtundu wa mankhwala omaliza.

Ndi limodzi makonzedwe a sulfonylurea zotumphukira, mlingo wawo amachepetsedwa kuti ateteze kukula kwa hypoglycemic state. Chifukwa cha chiwopsezo cha hypoglycemia, ndikofunikira kuthana ndi shuga pamankhwala othandizira Metformin, mahomoni apanchipisoni ndi Thiazolidinedione palimodzi ndi Vipidia.

Chifukwa cha chiwopsezo cha hypoglycemia, ndikofunikira kuthana ndi shuga panthawi ya Metformin.

Kusokonezeka Kwa Magazi

Potengera maziko ofooka chitetezo chokwanira, chotupa cha chapamwamba kupuma dongosolo ndi kukula kwa nasopharyngitis n`zotheka.

Pa khungu

Chifukwa cha kuchepa kwa minofu, zotupa pakhungu zimatha kuonekera. Mwachizolowezi, mawonekedwe a Stevens-Johnson syndrome, urticaria, matenda obwera ndi khungu.

Odwala omwe amawoneka ngati anaphylactoid zimachitika, urticaria, edema ya Quincke imawonedwa. Woopsa milandu, anaphylactic mantha.

Gwiritsani ntchito pa nthawi yoyembekezera komanso mkaka wa m`mawere

Kafukufuku wokhudzana ndi zamankhwala wokhudzana ndi mankhwalawa pa thupi la azimayi panthawi yoyembekezera sanachitike. M'nthawi yoyesera nyama, panalibe zotsatira zoyipa za mankhwalawa pakubala kwamayi, embryotoxicity, kapena teratogenicity ya Vipidia. Nthawi yomweyo, pazifukwa zotetezeka, mankhwalawa sanalembedwe kwa azimayi panthawi yoyembekezera (chifukwa cha chiwopsezo chophwanya kuyika kwa ziwalo ndi machitidwe pakukonzekera kwa embryonic).

Alogliptin imatha kupukusidwa kudzera m'magazi a mammary, chifukwa chake, munthawi yamankhwala othandizira, tikulimbikitsidwa kusiya msambo.

The ntchito aimpso kuwonongeka

Pamaso pa kulephera kwa impso pakati pa creatinine chilolezo (Cl) kuchokera pa 50 mpaka 70 ml / min, palibe zosintha zina zomwe zimachitika ku dosing regimen. Ndi Cl kuchokera pa 29 mpaka 49 ml / min, ndikofunikira kuti muchepetse chizolowezi cha tsiku lililonse mpaka 12,5 mg wa mlingo umodzi.

Pamaso pa kulephera kwa impso pakati pa creatinine chilolezo (Cl) kuchokera pa 50 mpaka 70 ml / min, palibe zosintha zina zomwe zimachitika ku dosing regimen.

Ndi kukanika kwambiri kwaimpso (Cl imafikira ochepera 29 ml / min), mankhwalawa amaletsedwa.

Kuchita ndi mankhwala ena

Mankhwalawa analibe kuyenderana ndi ma pharmacological ndi nthawi imodzi yoperekera Vipidia ndi mankhwala ena. Mankhwalawa sanaletse ntchito ya cytochrome isoenzymes P450, monoo oxygenase 2C9. Simalumikizana ndi magawo a p-glycoprotein. Alogliptin panthawi yophunzira zamankhwala sizinakhudze kusintha kwa khofi, Warfarin, Dextromethorphan, kulera kwapakamwa mu plasma.

Mankhwalawa samakhudza kusintha pamlingo wa Dextromethorphan m'thupi.

Kuyenderana ndi mowa

Pa mankhwala ndi mankhwalawa, ndizoletsedwa kumwa mowa. Ethanol yomwe ili ndi zakumwa zoledzeretsa zimatha kuyambitsa mafuta ku chiwindi chifukwa cha zovuta za hepatocytes. Mukatenga Vipidia, poizoni wotsutsana ndi hepatobiliary system imakulitsidwa. Mowa wa Ethyl umayambitsa kuperewera kwa dongosolo lamkati lamanjenje, umasokoneza magazi ndipo umakhala ndi diuretic. Chifukwa cha kuchuluka kwa mowa mthupi, zochizira zamankhwala zimachepa.

Magawo a mankhwala omwe ali ndi mankhwala omwe ali ndi mankhwala omwe ali ndi yogwira monga:

Mankhwala ofananira amasankhidwa ndi adotolo kutengera ndi zomwe zimapangitsa kuti wodwala azikhala ndi shuga komanso kuti wodwalayo alowereni. Kusintha kumachitika pokhapokha pakuchiritsa kapena pang'onopang'ono pomwepo.

Zizindikiro ndi contraindication kuti mugwiritse ntchito

Vipidia ndi mankhwala amkamwa a hypoglycemic. Chida ichi chikugwiritsidwa ntchito pochiza matenda a shuga a mtundu wachiwiri. Mankhwalawa a shuga amathandizira kusintha kwa glycemia m'magazi a munthu wodwala. Mankhwala amagwiritsidwa ntchito ngati kugwiritsidwa ntchito kwa mankhwala othandizira pakudya komanso kuchita masewera olimbitsa thupi mopatsa thupi sikufuna.

Mankhwala angagwiritsidwe ntchito ngati chinthu chokhacho pa monotherapy. Kuphatikiza apo, Vipidia ikhoza kugwiritsidwa ntchito kuphatikiza mankhwala ena a hypoglycemic mankhwalawa a mtundu 2 matenda a shuga monga njira yovuta yothandizira.

Mankhwala angagwiritsidwe ntchito pochiza matenda a shuga limodzi ndi insulin.

Monga mankhwala aliwonse, Vipidia imakhala ndi zotsutsana zingapo zomwe zimachepetsa kugwiritsa ntchito mankhwalawa. Mfundo zazikuluzikulu ndi izi:

• kupezeka kwa mtundu wachiwiri wa shuga wodwala, hypersensitivity to alogliptin ndi zigawo zina zothandizira za mankhwala,
• wodwala ali ndi matenda osokoneza bongo omwe amadalira insulin,
• kudziwa zizindikiro za ketoacidosis yomwe ikupezeka m'thupi la wodwalayo motsutsana ndi matenda ashuga,
• chizindikiritso choopsa cha mtima,
• zovuta mu chiwindi, zomwe zimayendera limodzi ndi kupezeka kwamagulu ogwira ntchito,
• kukula kwa matenda akhungu a impso, omwe amayenda limodzi ndi kupezeka kwa magwiridwe antchito,
• nthawi yobala mwana,
• Nthawi yonyamula mkaka
• zaka wodwala zafika 18.

Chenjezo liyenera kuchitika pamene wodwala ali ndi pancreatitis ndi kuwonongeka kwapang'onopang'ono pakugwira ntchito kwa impso ndi chiwindi.

Kuphatikiza apo, muyenera kusamala mukamagwiritsa ntchito mankhwalawa monga gawo la mankhwala a matenda a shuga a 2.

Malangizo ogwiritsira ntchito mankhwalawa

Mankhwala amatengedwa pakamwa. Nthawi zambiri, mankhwala achire omwe amalimbikitsidwa kuti agwiritse ntchito ndi 25 mg.

Mlingo wovomerezeka wa kugwiritsa ntchito mankhwalawa umaperekedwa ndi dokotala yemwe amaganizira zotsatira zomwe amapeza poyesa thupi la wodwalayo ndi machitidwe ake.

Mankhwalawa amatengedwa kamodzi patsiku, mankhwalawa amatengedwa mosasamala ndondomeko yakudya. Kumwa mankhwalawo limodzi ndi kumwa madzi ambiri.

Kugwiritsa ntchito mankhwala ndikotheka munthawi zotsatirazi:

1. Monga mankhwala a monotherapy a mtundu 2 matenda a shuga.
2. Pakukhazikitsa zovuta mankhwala a matenda, monga gawo la mankhwala. Mogwirizana ndi vipidia, metformin, sulfonylurea zotumphukira kapena insulin akhoza kumwedwa.

Pankhani ya Vipidia osakanikirana ndi Metformin, kusintha kwa mankhwalawa sikufunika. Kusintha kwa Mlingo kumafunika mukamagwiritsa ntchito mankhwala molumikizana ndi mankhwala omwe amachokera ku sulfonylurea kapena insulin.

Mlingo umasinthidwa kuti muchepetse kuyambika kwa zizindikiro za hypoglycemic mwa wodwala matenda a shuga.

Chenjezo liyenera kukulitsidwa mukamagwiritsa ntchito Vipidia pophatikiza ndi Metformin Teva ndi thiazolidatedione pochiza matenda ashuga.

Zizindikiro zoyambirira za hypoglycemia zitawoneka, mulingo wa Metformin ndi thiazolidinedione uyenera kuchepetsedwa.

Mukamamwa Vipidia, zotsatirazi zimakhala zotsatirazi:

• Kuchokera kumanjenje, kumachitika mutu pafupipafupi.
• Kuchokera m'mimba, mawonekedwe a kupweteka pamimba, ndikuponya zomwe zili m'mimba m'mimba, kukulira kwa zizindikiro za kapamba kakang'ono,
• Kuchokera ku hepatobiliary system, kumachitika pakuphwanya chiwindi.
• Thupi lawo siligwirizana mukuluma, zotupa, edema ya Quincke,
• kutupa kwa mphuno ndi pharynx n`zotheka,

Kuphatikiza apo, zotsatira zoyipa kuchokera ku chitetezo cha mthupi zimatha, kuwonetsa ngati anaphylaxis.

Ndemanga pa Vipidia 25

Pama intaneti pali ndemanga zabwino zochokera kwa azachipatala komanso malingaliro pa kugwiritsa ntchito mankhwalawa.

Anastasia Sivorova, endocrinologist, Astrakhan.

Chida chothandiza polimbana ndi matenda ashuga a 2. Olekerera bwino ndi odwala. Muzochita zamankhwala, samakumana ndi hypoglycemia. Mapiritsi ayenera kumwedwa nthawi imodzi popanda kuwerengera mosamala. Wothandizila hypoglycemic kuchokera m'badwo watsopano, chifukwa chake, sizimathandizira kuti thupi lizikula. Ntchito yogwira maselo a pancreatic beta imasungidwa.

Alexey Barredo, endocrinologist, Arkhangelsk.

Ndinkakonda kuti kugwiritsa ntchito mankhwalawa kwakanthawi, mawonekedwe osalimbikitsa samakhala. Mankhwala othandizira amakhala ndi vuto lochepa kwambiri, koma samawonekera nthawi yomweyo. Ndi yabwino kutenga - 1 nthawi patsiku. Mtengo wabwino wa ndalama. Sichimayambitsa zovuta kwa odwala.

Analogue ya mankhwalawa ndi Januvia.

Gabriel Krasilnikov, wazaka 34, Ryazan.

Ndimamwa Vipidia pa 25 mg kwa zaka 2 molumikizana ndi 500 mg ya Metformin m'mawa mutatha kudya. Poyamba, adagwiritsa ntchito Insulin malinga ndi dongosolo 10 + 10 + 8. Sizinathandize kuchepetsa bwino shuga. Zochita za mapiritsiwo ndizitali. Pambuyo pa miyezi itatu, shuga adayamba kutsika, koma patatha miyezi isanu ndi umodzi, shuga kuchokera 12 adagwa mpaka 4.5-5,5. Imapitilira kukhala mkati mwa 5.5. Ndinkakonda kuti kulemera kumachepa: kuyambira 114 mpaka 98 makilogalamu ndikuwonjezeka kwa masentimita 180. Koma muyenera kutsatira malangizo onse kuchokera pazomwe mwalandira.

Analogs popanga ndi chisonyezo chogwiritsidwa ntchito

Mutu	Mtengo ku Russia	Mtengo ku Ukraine
Nesina alogliptin	--	--

Mndandanda womwe uli pamwambapa wa analogies ya mankhwala, omwe akuwonetsa Vipidia, ndizabwino kwambiri chifukwa zimakhala ndi zinthu zomwe zimagwirizana ndipo zimagwirana molingana ndi chisonyezo chogwiritsidwa ntchito

Analogs mwa chisonyezo ndi njira yogwiritsira ntchito

Mutu	Mtengo ku Russia	Mtengo ku Ukraine
Januvia sitagliptin	1369 rub	277 UAH
Galvus vildagliptin	245 rub	895 UAH
Onglisa saxagliptin	1472 rub	48 UAH
Trazhenta linagliptin	89 rub	1434 UAH

Kuphatikizika kosiyanasiyana, kungagwirizane mukuwonetsa ndikugwiritsa ntchito njira

Mutu	Mtengo ku Russia	Mtengo ku Ukraine
Rosiglitazone wothandiza, metformin hydrochloride	--	--
Bagomet Metformin	--	30 UAH
Glucofage metformin	12 rub	15 UAH
Glucophage xr metformin	--	50 UAH
Reduxin Met Metformin, Sibutramine	20 rub	--
Dianormet	--	19 UAH
Diaformin metformin	--	5 UAH
Metformin metformin	13 rub	12 UAH
Metformin sandoz metformin	--	13 UAH
Siofor	208 rub	27 UAH
Fomu metformin hydrochloride	--	--
Emnorm EP Metformin	--	--
Megifort Metformin	--	15 UAH
Metamine Metformin	--	20 UAH
Metamine SR Metformin	--	20 UAH
Metfogamma metformin	256 rub	17 UAH
Tefor metformin	--	--
Glycometer	--	--
Glycomet SR	--	--
Forethine	37 rub	--
Metformin Canon metformin, ovidone K 90, wowuma chimanga, crospovidone, magnesium stearate, talc	26 rub	--
Insuffor metformin hydrochloride	--	25 UAH
Metformin-teva metformin	43 rub	22 UAH
Diaformin SR metformin	--	18 UAH
Mepharmil Metformin	--	13 UAH
Metformin Farmland Metformin	--	--
Glibenclamide Glibenclamide	30 rub	7 UAH
Maninyl Glibenclamide	54 rub	37 UAH
Glibenclamide-Health Glibenclamide	--	12 UAH
Glyurenorm glycidone	94 rub	43 UAH
Bisogamma Glyclazide	91 rub	182 UAH
Glidiab Glyclazide	100 rub	170 UAH
Diabeteson MR	--	92 UAH
Diagnizide mr Gliclazide	--	15 UAH
Glidia MV Gliclazide	--	--
Glykinorm Gliclazide	--	--
Gliclazide Gliclazide	231 rub	44 UAH
Glyclazide 30 MV-Indar Glyclazide	--	--
Glyclazide-Health Gliclazide	--	36 UAH
Glioral Glyclazide	--	--
Diagnizide Gliclazide	--	14 UAH
Diazide MV Gliclazide	--	46 UAH
Osliklid Gliclazide	--	68 UAH
Diadeon gliclazide	--	--
Glyclazide MV Gliclazide	4 rub	--
Amaril	27 rub	4 UAH
Glemaz glimepiride	--	--
Glian glimepiride	--	77 UAH
Glimepiride Glyride	--	149 UAH
Glimepiride diapiride	--	23 UAH
Guwa	--	12 UAH
Glimax glimepiride	--	35 UAH
Glimepiride-Lugal glimepiride	--	69 UAH
Clay glimepiride	--	66 UAH
Diabrex glimepiride	--	142 UAH
Meglimide glimepiride	--	--
Melpamide Glimepiride	--	84 UAH
Perinel glimepiride	--	--
Glempid	--	--
Wokongola	--	--
Glimepiride glimepiride	27 rub	42 UAH
Glimepiride-teva glimepiride	--	57 UAH
Glimepiride Canon glimepiride	50 rub	--
Glimepiride Pharmstandard glimepiride	--	--
Dimaril glimepiride	--	21 UAH
Glamepiride diamerid	2 rub	--
Amaryl M Limepiride Micronized, Metformin Hydrochloride	856 rub	40 UAH
Glibomet glibenclamide, metformin	257 rub	101 UAH
Glucovans glibenclamide, metformin	34 rub	8 UAH
Dianorm-m Glyclazide, Metformin	--	115 UAH
Dibizid-m glipizide, metformin	--	30 UAH
Douglimax glimepiride, metformin	--	44 UAH
Duotrol glibenclamide, metformin	--	--
Gluconorm	45 rub	--
Glibofor metformin hydrochloride, glibenclamide	--	16 UAH
Avandamet	--	--
Avandaglim	--	--
Janumet metformin, sitagliptin	9 rub	1 UAH
Velmetia metformin, sitagliptin	6026 rub	--
Galvus Met vildagliptin, metformin	259 rub	1195 UAH
Tripride glimepiride, metformin, pioglitazone	--	83 UAH
Comboglize XR metformin, saxagliptin	--	424 UAH
Comboglyz Prolong metformin, saxagliptin	130 rub	--
Gentadueto linagliptin, metformin	--	--
Vipdomet metformin, alogliptin	55 rub	1750 UAH
Sinjardi empagliflozin, metformin hydrochloride	240 rub	--
Voglibose Oxide	--	21 UAH
Glutazone pioglitazone	--	66 UAH
Dropia Sanovel pioglitazone	--	--
Lixumia lixisenatide	--	2498 UAH
Malo a Guarem Guar	9950 rub	24 UAH
Insvada repaglinide	--	--
Novonorm Repaglinide	30 rub	90 UAH
Repodiab Repaglinide	--	--
Baeta Exenatide	150 rub	4600 UAH
Baeta Long Exenatide	10248 rub	--
Viktoza liraglutide	8823 rub	2900 UAH
Saxenda liraglutide	1374 rub	13773 UAH
Forksiga Dapagliflozin	--	18 UAH
Forsiga Dapagliflozin	12 rub	3200 UAH
Invocana canagliflozin	13 rub	3200 UAH
Jardins Empagliflozin	222 rub	566 UAH
Trulicity Dulaglutide	115 rub	--

Kodi mungapeze bwanji analogue yotsika mtengo ya mankhwala okwera mtengo?

Kuti mupeze chiwonetsero chotsika mtengo cha mankhwala, chofananira kapena chofanana, choyambirira timalimbikitsa kulabadira kapangidwe kake, zomwe ndi zinthu zomwezo zomwe zikugwira komanso zomwe zikugwiritsidwa ntchito. Zomwe zimagwiritsidwanso mosiyanasiyana ndi mankhwalawa zimawonetsa kuti mankhwalawo ndi ofanana ndi mankhwalawo, monga mankhwala ena kapena mitundu ina. Komabe, musaiwale za zovuta zomwe zimagwiritsidwa ntchito ndi mankhwala ofanana, omwe angakhudze chitetezo ndi kugwiranso ntchito. Musaiwale za malangizo a madotolo, kudzipereka nokha kungawononge thanzi lanu, chifukwa chake onani dokotala wanu musanagwiritse ntchito mankhwala.

Malangizo a Vipidia

MALANGIZO
pa kugwiritsa ntchito ndalama
Vipidia

Mlingo
12,5 mg ndi 25 mg mapiritsi okhala ndi mafilimu

Kupanga
Piritsi limodzi lili
yogwira mankhwala: alogliptin benzoate 17 mg (wofanana ndi 12.5 mg wa alogliptin) ndi 34 mg (wofanana ndi 25 mg wa alogliptin)
zokopa:
Core: mannitol, cellcrystalline cellulose, hydroxypropyl cellulose, croscarmellose sodium, magnesium stearate,
Zomwe zimapangidwa ndi membrane wa filimuyi: hypromellose 2910, titanium dioxide (E 171), iron oxide chikasu (E 172), iron oxide ofiira (E 172), polyethylene glycol 8000, inki ya imvi F1

Kufotokozera
Mapiritsi a Oval biconvex, opakidwa utoto wamafuta wachikaso, olembedwa "TAK" ndi "ALG-12.5" mbali imodzi ya piritsi (pamlingo wa 12.5 mg),
Mapiritsi a Oval biconvex ophatikizidwa ndi utoto wa kanema wa mtundu wofiira wopepuka, wokhala ndi mawu akuti "TAK" ndi "ALG-25" mbali imodzi ya piritsi (pa mulingo wa 25 mg).

Gulu la Pharmacotherapeutic
Njira zochizira matenda ashuga. Mankhwala ochepetsa shuga a pakamwa. Zoletsa za dipeptidyl peptidase-4 (DPP-4). Alogliptin

Nambala ya ATX A10BH04

Mankhwala
Pharmacokinetics
Ma pharmacokinetics a alogliptin adawerengeredwa m'maphunziro omwe akukhudza onse odzipereka athanzi komanso odwala matenda a shuga a mtundu wachiwiri.Mwa odzipereka athanzi, pakapita pakamwa kamodzi mpaka 800 mg ya alogliptin, kuyamwa mwachangu kwa mankhwalawa kumawonedwa ndi kuchuluka kwa plasma kwa ola limodzi mpaka awiri kuchokera pa nthawi ya makonzedwe (a Tmax). Pambuyo kumwa pazovomerezeka zochizira mlingo wa mankhwalawa (25 mg), theka lomaliza la moyo (T1 / 2) pafupifupi maola 21.
Pambuyo poyang'anira mobwerezabwereza mpaka 400 mg kwa masiku 14 kwa odwala omwe ali ndi matenda a shuga a 2, kuchuluka kwambiri kwa alogliptin kunawonedwa ndi kuwonjezeka kwa malo omwe ali pansi pa pharmacokinetic curve (AUC) komanso pazambiri za plasma ndende (Cmax) ndi 34% ndi 9%, motero. Ndi mulingo wambiri komanso zingapo za alogliptin, AUC ndi Cmax zimachulukana molingana ndi kuchuluka kwa mlingo kuchokera 25 mg mpaka 400 mg. Kuthekera kosiyanasiyana kwa AUC ya alogliptin pakati pa odwala ndi kochepa (17%).
Zogulitsa
Mtheradi bioavailability wa alogliptin pafupifupi 100%. Popeza mukamamwa alogliptin ndi chakudya chamafuta ambiri, osakhudzidwa ndi AUC ndi Cmax, mankhwalawa amatha kutengedwa mosasamala zakudya.
Kugawa
Pambuyo pakuwongolera kamodzi kwa alogliptin pa mlingo wa 12,5 mg mu odzipereka athanzi labwino, kuchuluka kwa magawo mu terminal anali 417 L, zomwe zikuwonetsa kuti alogliptin imagawidwa bwino mu minofu.
Kuyankhulana ndi mapuloteni a plasma ndi 20%.
Kupenda
Alogliptin sathanidwa ndi kagayidwe kakakulu, chifukwa chomwe 60% mpaka 71% ya mlingo womwe umayendetsedwa sichimasinthidwa mumkodzo. Pambuyo pakukonzekera kwa 14C-olembedwa alogliptin, ma metabolites ang'onoang'ono anali otsimikiza: N-demethylated alogliptin M-I (˂1% yazinthu zoyambira) ndi N-acetylated alogliptin M-II (˂6% yazinthu zoyambira). M-I ndi metabolite wogwira komanso wosankha wa DPP-4, wofanana ndi alogliptin, M-II samawonetsa zochitika zoletsa DPP-4 kapena ma enzyme ena a DPP. Kafukufuku wa in vitro awulula kuti CYP2D6 ndi CYP3A4 zimathandizira kagayidwe kochepa ka alogliptin. Alogliptin imakhalapo makamaka mu mawonekedwe a (R) enantiomer (> 99%) ndipo pansi pazinthu za vivo imadutsa pang'ono kutembenuka kwa chiral kupita ku (S) enantiomer. (S) -enantiomer sazindikira pamene akumwa alogliptin mu Mlingo wothirira (25 mg).
Kuswana
Pambuyo pa 14C-yokhala ndi alogliptin, 76% ya radioactivity yonse imatsitsidwa ndi impso ndi 13% m'matumbo, mpaka 89% ya mlingo woyenera wa radioactive. Chilolezo cha alogliptin (9,6 L / h) chikuwonetsa kubisala kwa impso. Chilolezocho ndi 14.0 l / h.
Pharmacokinetics m'magulu apadera odwala:
Matenda aimpso
AUC ya alogliptin mwa odwala omwe ali ndi vuto laimpso kuwonda kwambiri (60in creatinine chilolezo (CrCl) Zonse zimafotokozedwera mwatsatanetsatane ndipo sizifukwa zodzipangira nokha mankhwala

Mtengo wa Vipidia ndi fanizo zake

Kugwiritsa ntchito mapiritsi a Vipidia a matenda ashuga nthawi zambiri kumakhala koyenera.

Ngati tiweruza mankhwalawa poyerekeza kuti anthu omwe amagwiritsa ntchito Vipidia amasiya za ichi, titha kunena kuti mankhwalawa ndi mankhwala othandiza kwambiri omwe amatha kuwongolera bwino matenda a glycemia m'thupi la munthu yemwe akudwala matenda a shuga a mtundu wachiwiri.

Mankhwala chopangira chogwira, chomwe ndi alogliptin mpaka pano, kuwonjezera pa Vipidia sichinalembedwe.

Mankhwala opangidwa, omwe amagwira ntchito omwe amaphatikizidwa ndi gulu la incretinomimetics.

Mankhwala omwe ali ngati chiwongola dzanja cha Vipidia ndi awa:

1. Januvia ndi mankhwala a hypoglycemic opangidwa pamaziko a sitagliptin. Kutulutsidwa kwa mankhwalawa kuli ngati mapiritsi omwe ali ndi 25, 50 ndi 100 mg yogwira ntchito. Zizindikiro zogwiritsira ntchito Januvia ndizofanana ndi zomwe Vipidia ali nazo. Mankhwalawa amatha kugwiritsidwa ntchito ndi monotherapy kapena chithandizo chovuta.
2. Yanumet ndi kukonzekera kovuta, komwe kumakhala ndi sitagliptin ndi metformin ngati zigawo zogwira ntchito. Mlingo wa gawo loyambirira ndi 50 mg, ndipo metformin pakapangidwe ka mankhwala atha kukhala osiyanasiyana. Mankhwalawa amapezeka m'mitundu itatu - 50, 850 ndi 1000 mg.
3. Galvus ngati gawo logwira lomwe lili ndi vildagliptin, yomwe ndi analogue ya alogliptin. Mlingo wa zomwe zimagwiritsidwa ntchito pokonzekera ndi 50 mg. Mlingo wa metformin wopangidwa ndi mankhwalawa ndi 500, 850, ndi 1000 mg.
4. Onglisa mu kapangidwe kake ngati yogwira popanga pali saxagliptin. Pulogalamuyi ikukhudzana ndi zinthu zomwe zimalepheretsa enzyme kutsitsa incretin. Mankhwala amapezeka mu mlingo wa 2,5 ndi 5 mg.
5. Comboglyz Prolong ndi kuphatikiza kwa saxagliptin ndi metformin. Mankhwalawa amapezeka piritsi. Kutulutsidwa kwa magawo omwe amagwira ntchito kumachitika mu mawonekedwe osachedwa.
6. Trazhenta ndi mankhwala a hypoglycemic opangidwa pamaziko a linagliptin. Kuphatikizika kwa mankhwalawa kumakhala ndi 5 mg yogwira ntchito.

Mtengo wa mankhwala umatengera dera lomwe mankhwalawo amagulitsidwa ku Russia. Mtengo wapakati wa mankhwalawa ndi ma ruble 843.

Ndi zithandizo zina ziti zomwe zingagwiritsidwe ntchito pochiza matenda osokoneza bongo zomwe zafotokozedwa muvidiyoyi.