Mankhwala "Glucophage": ndemanga yakuchepetsa thupi ndi madotolo, malangizo ogwiritsira ntchito

Ndani mwa achinyamata amakono omwe safuna kukhala wocheperako komanso wokhala ndi mawonekedwe okongola? Koma kupanga zakudya zoyenera ndi kuchita masewera olimbitsa thupi nthawi zonse kumakhala kovuta, chifukwa muyenera kukhala ndi mphamvu kuti muwone cholinga ndikukwaniritsa zotsatira. Ndiosavuta kumwa mankhwala ozizwitsa ndikuchepetsa mphamvu yakugona pa sofa kukumbatirana ndimakoko ndi tchipisi.

Nthawi zambiri anthu amadzisankhira okha mankhwala omwe angagulidwe ku pharmacy, ndikuyamba kumwa poyembekezera kuti ataya pafupifupi 10 kg pa sabata. Nthawi zambiri, iwo amene akufuna kuchepa thupi alibe chidwi ndi cholinga chachikulu cha mankhwala omwe adagula. Lero tikulankhula za mankhwala monga Glucofage. Ndemanga yakuchepetsa thupi amanenapo za iye ngati njira yothandiza kwambiri yochepetsera thupi, pomwe mankhwalawa amapangidwira odwala omwe ali ndi matenda a shuga a mtundu wachiwiri.

The kapangidwe ndi kumasulidwa mawonekedwe a mankhwala "Glucophage"

Metformin hydrochloride ndiye chinthu chogwira ntchito cha mankhwalawo. Zothandiza ndi izi: magnesium stearate, povidone, hypromellose (2910 ndi 2208), microcrystalline cellulose. Mankhwalawa amapezeka mu mawonekedwe a mapiritsi okhala ndi Mlingo wofunikira kwambiri mu 500, 850 ndi 1000 mg. Mapiritsi a Biconvex ndiwotupa. Amatetezedwa ndi chovala choyera cha filimu. Pali zoopsa kumbali zonse za piritsi, pa imodzi mwa izo mwawonetsedwa.

Komanso ogula amapatsidwa wothandizira kuti amasulidwe - Glucofage Long. Ndemanga za ogwiritsa ntchito mankhwalawa zimawonekeranso pamankhwala abwino. Mankhwala omwe amafunsidwa kawirikawiri m'mafakisoni ndi 500 ndi 750 mg ya metformin.

Kugwirizana kwa "Glucophage" ndi kuwonda: mfundo yofunikira

Gawo lalikulu la mankhwalawa, metformin, limapangidwa kuti muchepetse kuchuluka kwa shuga m'magazi, omwe amawonjezereka atatha kudya (njira yachilengedwe yamoyo m'chilengedwe chamoyo). Kenako kapamba amalumikizidwa ndi njirayi, ntchito zomwe zimaphatikizapo kupanga insulin. Hemeniyu, amasintha glucose kukhala maselo amafuta.

Mwa zabwino zazikulu za mankhwala "Glucofage Long" chifukwa cha kuwonda, zotsatirazi zitha kudziwika:

• matenda a lipid metabolism osagwirizana ndi matenda a shuga,
• kuletsa kuwonongeka kwa mafuta omwe amalandiridwa ndi chakudya, ndipo, potero, kusintha kwawo kukhala mafuta amthupi,
• kuwunikira komanso kusintha matenda a shuga ndi mafuta “oyipa” omwe ali m'magazi,
• kuchepa kwachilengedwe pachilakolako ndi kusilira kwa maswiti, komwe kumalumikizidwa ndi kubereka kwa kapangidwe ka insulin.

Zinthu zonsezi pamodzi zimathandizira odwala matenda ashuga kuwongolera kuchuluka kwa shuga ndikuwongolera kwambiri moyo wawo potengera njira za endocrine.

Mphamvu ya metformin imayambitsa kutsika kwa glucose wamagazi, ndipo mamolekyulu a shuga amayenda molunjika kumtunda. Ndi pomwepo kuti shuga amawotcha kwambiri, mafuta acids amaphatikizidwa, ndipo mayamwidwe amkati amachepetsa (i.e., maselo amafuta samayikidwa ndikudziunjikira).

Kuphatikiza apo, mankhwala a Glyukofazh ndi Glyukofazh Long, kuwunika kwa iwo omwe achepetsa thupi kumawapatsa mwayi wochepetsa kudya, chifukwa chomwe palibe kudya kwambiri ndipo, chifukwa chake, insulin imatulutsidwa m'magazi.

Mlingo komanso dongosolo la momwe mungagwiritsire ntchito

Mankhwala "Glucofage Long" samalimbikitsa kutenga malangizo ogwiritsa ntchito popanda mankhwala a dokotala. Ngakhale kuchuluka kokwanira kwa ogwira ntchito yazaumoyo ali ndi chiyembekezo chogwiritsa ntchito zopangidwa ndi metformin kuti muchepetse kunenepa.

Mitundu yovomerezeka ndi njira yochizira kuyambira masiku 10 mpaka 22, ndiye kuti muyenera kupuma kwa miyezi iwiri. Pakapita kanthawi, maphunzirowo atha kubwerezedwa. Pogwiritsa ntchito pafupipafupi, pamakhala mwayi kuti thupi lizisinthasintha (kugwiritsa ntchito) mankhwalawa ndikuchepetsa mphamvu zake, ndiye kuti, metformin imataya mwayi wowonetsa bwino mawonekedwe owotchera mafuta.

Dokotala amasankha mulingo woyenera aliyense payekha kwa wodwala aliyense, kutengera mtundu waumoyo komanso magawo a anthropometric (kulemera, kutalika, msinkhu). Kuchuluka kwa tsiku lililonse kwa mankhwalawa ndi 500 mg. Nthawi zambiri kumwa mapiritsi usiku. Komabe, nthawi zambiri "Glucofage 500" yochepetsa thupi imayikidwa kawiri masana, nthawi ya nkhomaliro komanso madzulo. Pafupipafupi, mlingo ungathe kuwonjezeredwa mpaka 3 Mlingo - 1,500 mg patsiku (mwachilengedwe, osati palokha, koma monga momwe adanenera dokotala). Pankhaniyi, ndizomveka kuyang'anira magwiridwe anthawi yayitali "Glucofage Long 750" kuti muchepetse kunenepa. Kuunika kwa madotolo ndi odwala kumawonetsa chida ichi kukhala chothandiza komanso chosavuta kugwiritsa ntchito (1500 mg mu Mlingo iwiri). Mapiritsi aledzera musanadye kapena nthawi ya chakudya.

Mlingo wapamwamba wa tsiku lililonse wa mankhwalawa (apanso, monga momwe adanenera dokotala) sangadutse 3000 mg. Panthawi iyi, ndibwino kumwa Glucofage 1000 kuti muchepetse thupi (katatu patsiku piritsi lokhala ndi metformin mu 1000 mg).

Kuchepetsa pang'onopang'ono kwa mankhwalawa kungakhudze kukonzekera kwa m'mimba kwa mankhwalawa.

Ndani ayenera kupewa kugwiritsa ntchito mankhwalawa?

Popeza Glucofage sikuti ndi vitamini kapena zakudya zowonjezera, koma adapangira kuti azigwiritsidwa ntchito ndi odwala omwe ali ndi matenda amtundu wa 2, ali ndi mndandanda wochititsa chidwi wa zotsutsana.

Anthu athanzi omwe amamwa mankhwala a metformin amakhala ndi chiopsezo chokhala ndi vuto la kuperewera kwa thupi, lomwe limadziwonetsa pang'onopang'ono momwe thupi la munthu limayendera insulin yake. Izi zimadzetsa chitukuko cha matenda ashuga.

Kupitilira apo, onse Glucofage ndi Glucofage Long amaletsa kugwiritsa ntchito malangizo kwa anthu omwe ali ndi chidwi chochulukirapo pazigawo zina. Kupatuka kulikonse pakugwira ntchito kwa impso, chiwindi, mtima ndi zifukwa zokwanira zokanira kugwiritsa ntchito mankhwalawa. Matenda aliwonse omwe ali pachimake kwambiri, nthawi yokonzanso ntchito, kupweteka kwa thupi, mkaka - izi zonse zimaletsa kugwiritsa ntchito "Glucofage" kuchepetsa thupi.

Musamwe mankhwala kwa odwala omwe ali ndi vuto lililonse la matenda ashuga: odwala matenda amtundu 1, komanso mtundu uwu wa matenda ashuga 2, pomwe wodwalayo alibe insulin mthupi. Sizoletsedwa kutenga Glucophage kwa anthu omwe ali ndi magazi m'thupi, matenda oopsa a bronchopulmonary, mavuto amtundu wa hematological momwe magazi acid apamwamba kuposa abwinobwino.

Mawonetsero osayenera

Popeza mankhwalawa adapangidwa kuti athane ndi matenda oopsa monga matenda a shuga, sangalephere kukhala ndi zotsatirapo zilizonse. Nthawi zambiri, zomwe zimachitika pakumwa mankhwala "Glucophage" zimachitika. Ndemanga yakuchepetsa thupi inena zamatenda amtundu uliwonse.

Ngati, motsutsana ndi maziko ogwiritsa ntchito mankhwala okhala ndi metformin kuti muchepetse kunenepa, kutsekula m'mimba kapangidwe kapenanso kupangika kwa matumbo m'matumbo kumawonjezereka, chifukwa chake chingakhale chakudya chochuluka mwa chakudya. Muyenera kuwerengera zomwe mumadya tsiku lililonse. Ngati mukusanza mukamwa mankhwalawa, muyenera kuchepetsa kuchuluka kwa mankhwalawa. Nthawi zambiri mumatha kumva za ma spasms m'matumbo ndi mutu womwe umachoka mwachangu.

Popereka mankhwala a Glucophage ndi Glucophage Long slimming kwa odwala, kuwunika kuyeneranso kukumbukiridwa. Ogwira ntchito zachipatala ati kuchuluka kwa zotsatirapo zake kumazimiririka lokha patatha masiku ochepa chiyambireni mankhwalawa kapena atangomaliza kumwa.

Pamaso pa zinthu zomwe zimayambitsa vuto, lactic acidosis imayamba. Kuchita koteroko kumawonedwa kukhala koopsa kwambiri. Chofunikira chake ndi kuwonjezera maphunziro ndi metabolism yosayenera m'thupi la lactic acid. Zizindikiro zotsatirazi zikuwonetsa kukhalapo kwa izi pakukonzekera kwa Glucofage: kusanza, kutsegula m'mimba, kupumira mwachangu, kupweteka pamimba, kusiya kugona. Kukula kwa zotere kumafunika kuchotsedwa kwa mankhwalawa, kuchipatala mwachangu kuti mupeze mulingo wa lactate m'magazi komanso molingana ndi zotsatira za chithandizo chamankhwala. Pochotsa metformin ndi mkaka wa mthupi, chithandizocho chikhala chothandiza kwambiri.

Kukhazikika kosagwiritsidwa ntchito kwa mankhwalawa pogwiritsa ntchito metformin kumatha kuyambitsa zovuta muubongo (monga kuwonetsa kuchepa kwa shuga) komanso kukula kwa matenda osokoneza bongo.

Malangizo apadera

Ngakhale odwala omwe amamwa mankhwala mu Mlingo wocheperako (kuyambira Glucofage 500) chifukwa cha kuchepa thupi amatha kukhala ndi malingaliro olakwika kwambiri ngati malangizo osagwiritsidwa ntchito satsatiridwa. Muyenera kusiya zakudya zomwe zili ndi chakudya chochuluka: zipatso zouma, koloko, maswiti ndi zakudya zina zokhala ndi shuga. Zosathandiza kwambiri panthawiyi azikhala kudya chimanga, mbatata, pasitala ndi mpunga woyera.

Kugwiritsa ntchito mankhwala okhala ndi metformin motsutsana ndi zakudya zama calorie otsika (zakudya zosaposa 1000 kcal) zomwe zimakhala ndi zakumwa zoledzeretsa ndi zakumwa sizigwirizana kwenikweni.

Palibe zakudya zapadera mukamagwiritsa ntchito Glucofage. Palibe zoletsa zapadera pa zonunkhira ndi mchere mwina.

Kuchita ndi mankhwala ena

Zambiri pazomwe mungatengere "Glucophage" zili m'malangizo ogwiritsira ntchito mankhwalawa. Kudya limodzi ndi danazol kungapangitse kukula kwa vuto la hyperglycemic. Kugwiritsa ntchito munthawi yomweyo kukonzekera kwa metformin ndi zinthu za ethanol kumatha kuyambitsa lactic acidosis panthawi yamkati poyizoni wakumwa. Kuthekera kotenga gawo lotereli kumakulirakulira ndi njala, zakudya zopatsa mphamvu pang'ono komanso kulephera kwa chiwindi.

Odwala omwe ali ndi matenda ashuga ayenera kusamala akamagwiritsa ntchito Glucofage ndi antipsychotic kapena glucocorticosteroids (GCS). Zikatero, mlingo wa mankhwala omwe ali ndi metformin uyenera kusinthidwa malinga ndi kuchuluka kwa shuga m'magazi. Kuphatikiza kwa Glucophage ndi loopback diuretics kumafunikanso chisamaliro chapadera. Zikatero, pamakhala chiopsezo pakupatuka kwa impso ndipo, chifukwa chake, kukula kwa zizindikiritso za lactic acidosis.

Mankhwala othandizira magazi amatha kuchepetsa magazi. Chifukwa chake, pakafunika "mdera" lotere, muyeso wa metformin uyenera kusinthidwa.

Glucophage ndi zolimbitsa thupi

Osati kale kwambiri, ponena za kuchita zolimbitsa thupi komanso kugwiritsa ntchito mankhwala a Glucofage, kuwunika kwa kunenepa kwambiri ndipo ogwira ntchito zachipatala adavomereza kuti muzochitika zoterezi zimathandizira kwambiri, chifukwa lactic acid imatulutsidwa m'mitsempha, yomwe imanyalanyaza mphamvu ya mankhwalawa chifukwa cha kuchuluka kwa acidity magazi. Komabe, kafukufuku waposachedwa m'derali watsimikizira zokayikitsa. Komanso, tsopano zikuwonekeratu kuti Glucophage ndi moyo wokangalika pamodzi zimathandizira njira yochepetsera thupi.

Ngakhale mutatenga mankhwala ochepa a metformin (mwachitsanzo, Glucofage 500), kuwunikira kwa kuchepetsa thupi (omwe saiwala zolimbitsa thupi) nthawi zambiri kumakhala koyenera. Chowonadi ndi chakuti gawo lalikulu la mankhwalawo limathandizira kuperekera shuga mwachindunji kwa minofu, komwe imatenthedwa bwino, ngati munthu amene akufuna kuchepa thupi saayiwala za masewera olimbitsa thupi. Kupanda kutero, ma metabolic a thupi "amayendetsa" glucose mozungulira mpaka atatembenuka kukhala glycogen ndipo sasintha kukhala mafuta. Chifukwa chake, mathedwe amadzitsimikizira okha: Asanatenge "Glucophage", ndikofunikira kupanga pulogalamu yochita zolimbitsa thupi ndikutsatira mosamalitsa. Ndi pokhapo izi pomwe zotsatira zabwino zingayembekezeredwe.

Kodi lingaliro la ogwira ntchito yazaumoyo ndi chiyani pa Glucofage?

Pakadali pano, madokotala alibe mgwirizano pa kutha ndi chitetezo cha metformin pakuchepetsa thupi. Chithandizo chamankhwala sichimaletsa kugwiritsa ntchito Glucophage ndi Glucophage Long pochizira kunenepa. Ndemanga za akatswiri ambiri azachipatala ndi zabwino. Ngakhale gawo lina la madokotala limawona kuti chithandizo chotere sichobvomerezeka, chifukwa mankhwalawa angapangitse kupatuka mu kayendedwe ka car metabolic metabolism, amachititsa kukula kwa matenda a shuga ndi lactic acidosis, omwe amawopseza moyo wa wodwalayo.

Pofuna kumveketsa chowonadi mmaiko ambiri padziko lapansi, maphunziro oyenerera akuchitika pankhaniyi. Chifukwa chake, mu 2014, maphunziro adachitika pamaziko a Cardiff University, momwe anthu pafupifupi 180,000 adatenga nawo gawo. Zotsatira zake, zidatsimikiziridwa kuti metformin ndi kukonzekera komwe kuli nako kumatha kuwonjezera kuchuluka kwa moyo osati mwa anthu omwe ali ndi matenda ashuga okha, komanso mwa iwo omwe sazindikira. Kuphatikiza apo, zidapezeka kuti kugwiritsa ntchito metformin kumachepetsa kukalamba mthupi.

Malingaliro odwala

Popeza makambirano sakukhudzana ndi zowonjezera mavitamini kapena mavitamini, koma za mankhwala oopsa, ndizachilengedwe kuti pamakhala malingaliro osiyanasiyana za iwo pakati pa ogula.

Kumbali imodzi, odwala omwe adamwa ngakhale mankhwala ochepa kwambiri (mwachitsanzo, nthawi imodzi yotsatila Glucofage 500), ndemanga zimasiya zabwino kwambiri pamankhwala. Ndipo kuchepa kwa njala kumawonekera, ndipo kulemera kwamthupi kumachepa. Zowona, ena amakhulupirira kuti kulemera kumachepetsedwa pang'onopang'ono, 2-3 kg kupitilira mwezi. Komabe, ogwira ntchito yazaumoyo amawona kuti mlingo uwu ndiwopeza bwino kwambiri thupi lonse. Chofunika kwambiri, musadzipangire nokha. Onetsetsani kuti mukumana ndi dokotala yemwe amayesa momwe wodwalayo alili, aganize kutalika kwake, kuchuluka kwake, msinkhu wake, sankhani mlingo woyenera kwambiri ndikukhala ndi njira yabwino yokwanira.

Pali odwala omwe anayesera kutenga Glucofage (okha, chifukwa katswiri woyenera wamankhwala sangapange nthawi yoikidwiratu) kuti apange minofu pomanga thupi. Apa muyenera kudziwa kuti limagwirira a anabolic, yomwe ndiyofunikira kwambiri kuti minofu ikule, imayambitsa mndandanda wonse wa zinthu, kuphatikizapo glucose ndi insulin. Ndipo "Glucophage" ndi mankhwala aliwonse okhala ndi Metformin amapangitsa kuti thupi lipangike, lofanana ndi njala, lomwe limabwera atatha kulimbitsa thupi.Chifukwa chake, kuwunikira kwa odwala kotere kuti mankhwalawa sanathandize.

Pali zovuta zokwanira zogwiritsa ntchito mankhwalawa "Glucofage." Ndemanga ya kuchepa thupi lipoti la kuchepa mphamvu, kakulidwe kazotsatira zoyipa. Zikatero, wina sakanakhoza kulekerera kwa masiku angapo mpaka thupi litazungulira ku Glucofage. Kwa ena, kukhalapo kwa matenda othandizirana kumadzetsa mavuto ambiri, ndipo simungathe kuchita kalikonse pano - muyenera kulabadira mankhwala ena kuti muchepetse kunenepa kwambiri. Ndipo wina sanalandire malingaliro a malangizo omwe angagwiritsidwe ntchito pakuchepetsa kudya kwa zakudya zamagulu ochulukirapo, kusakanikirana kophatikiza metformin ndi zakudya zama calorie ochepa, zinthu zakumwa zoledzeretsa, okodzetsa, antipsychotic ndi zinthu zina.

Nthawi zambiri, ndemanga zoyipa zokhudza Glucofage zitha kunenedwa pokhapokha ngati mankhwalawa akumwa, omwe amachokera ku gulu lalikulu, amapangidwira makamaka odwala matenda a shuga, ndipo amatha kusokoneza kagayidwe kazakudya mwa munthu wathanzi.

Ubwino wa mankhwalawa ndikuti Glucofage ndi yotsika mtengo kwambiri ndipo imagulitsidwa pa intaneti yopanda mankhwala popanda mankhwala, zomwe zimapangitsa kuti anthu athe kupeza ndalama iliyonse.

Mulimonsemo, musanapitirize ndi kulandira Glucofage kuti muchepetse kunenepa, muyenera kufunsa uphungu wa akatswiri azachipatala omwe ali ndi mbiri yoyenera. Iyi ndiye njira yokhayo yopezera zotsatira zabwino popanda kuyika thupi lanu pangozi.

Kutulutsa mawonekedwe ndi kapangidwe kake ka mankhwala

Chofunikira kwambiri mwa mankhwalawa ndi metformin hydrochloride. Komabe, kuwonjezera pa izi, zida zothandizira zimaphatikizidwanso. Izi zimaphatikizapo povidone, magnesium stearate, microcrystalline cellulose ndi hypromellose. Mankhwala "Glucophage" (kuwonda pakuwunikira akufotokozedwa pansipa) ali ndi mawonekedwe a mapiritsi, omwe amasiyana mu kuchuluka kwa zinthu zomwe zimagwira. Mwachitsanzo, piritsi limodzi limatha kukhala 500, 850 kapena 1000 mg yogwira ntchito. Piritsi lirilonse limakhala ndi mawonekedwe a biconvex ndipo limakulungidwa ndi nembanimu yoyera. Phukusi limodzi nthawi zambiri limakhala ndi mapiritsi makumi atatu.

Chifukwa chiyani chida ichi chimatsogolera kuwonda

Mapiritsi a Glucophage amafotokozedwa mu malangizo ogwiritsira ntchito ngati njira yochizira matenda a shuga a 2. Komabe, mankhwalawa amagwiritsidwa ntchito nthawi zambiri moyenera kuchepetsa thupi. Chifukwa chiyani mankhwalawa amatchuka kwambiri ndi anthu oonda?

Metformin imatha kuchepetsa shuga m'magazi, omwe amakwera kwambiri pambuyo pa chakudya chilichonse. Njira zoterezi zimakhala zachilengedwe mthupi, koma ndi matenda ashuga amasokonezeka. Komanso mahomoni opangidwa ndi kapamba amalumikizidwa ndi njirayi. Amathandizira pakusintha shuga kukhala maselo amafuta.

Chifukwa chake, kumwa mankhwalawa, odwala amatha kuwongolera shuga, komanso kusintha momwe timadzi mu thupi timagwirira ntchito. Metformin imakhala yosangalatsa kwambiri mthupi la munthu. Amachepetsa kwambiri magazi chifukwa cha kudya mwachindunji kwa minofu minofu. Chifukwa chake, shuga amayamba kuwotcha, osasanduka mafuta osungira. Kuphatikiza apo, mankhwalawa "Glucophage" ali ndiubwino wina. Ndemanga zakuchepetsa thupi zimatsimikizira kuti chida ichi chimapangitsa kuti chishuwere. Zotsatira zake, munthu samangodya chakudya chochuluka.

"Glucophage": malangizo ogwiritsira ntchito

Kumbukirani, kudzipereka nokha sikuti sikungakhale njira iliyonse. Mankhwala oterowo ayenera kuyikidwa kokha ndi katswiri.M'malo mwake, owerengeka kwambiri amathandizira odwala awo kumwa mapiritsi a Glucofage moyenera kuti achepetse thupi. Chida choterocho chikuyenera kugwiritsidwa ntchito, motsogozedwa ndi dongosolo lapadera. Nthawi zambiri, njira ya mankhwalawa imatenga masiku 10 mpaka 22, pambuyo pake ndikulimbikitsidwa kuti mupumule kwa miyezi iwiri. Pambuyo pa nthawi iyi, ngati pangafunike, maphunzirowo atha kubwereza. Chonde dziwani kuti ngati mumagwiritsa ntchito mankhwalawa pafupipafupi, pali kuthekera kwakukulu koti thupi lanu limangoligwiritsa ntchito, zomwe zikutanthauza kuti njira yoyaka mafuta idzayimitsidwa.

Mlingo amasankhidwa ndi dokotala payekhapayekha. Katswiriyu ayenera kuganizira za thanzi lanu, komanso jenda, kulemera kwake komanso kutalika kwake. Komabe, mlingo wocheperako tsiku lililonse ndi piritsi limodzi lokhala ndi 500 mg yogwira ntchito patsiku. Koma nthawi zambiri pakuchepetsa thupi mankhwala "Glucofage" siomwe amatengedwa. Ndemanga zakuchepetsa thupi zimatsimikizira kuti zotsatira zabwino kwambiri zimatheka pokhapokha mutamwa mapiritsi awiri a mankhwalawa tsiku lililonse. Nthawi yomweyo, muyenera kuchita izi nthawi ya nkhomaliro komanso madzulo. Osati kawirikawiri, mlingo umakulitsidwa kumapiritsi atatu patsiku. Komabe, kuchuluka kwa mankhwalawa kungapangidwe ndi dokotala.

Anthu ambiri ali ndi chidwi ndi funso lofunsidwa: Kodi ndibwino - "Glyukofazh" kapena "Glukofazh Long"? Dokotala wanu adzayankha funso ili. Ngati mankhwalawa okwanira a metformin ndi oyenera kwa inu, ndiye kuti ndibwino kulabadira mankhwala achiwiriwo, chifukwa amakhala ndi mphamvu yayitali mthupi. Piritsi lililonse liyenera kumwedwa nthawi yomweyo musanadye kapena chakudya. Imwani mapiritsiwo ndi madzi pang'ono. Ndikofunika kuwonjezera mlingo pang'onopang'ono. Izi zithandiza bwino m'mimba thirakiti.

Yemwe samalimbikitsidwa kumwa mankhwalawa

Musaiwale kuti Glucophage, mtengo womwe umasonyezedwa pansipa, siwowonjezera vitamini. Mankhwalawa amapangidwa makamaka pochiza matenda amishuga a 2. Chifukwa chake, muyenera kuigwiritsa ntchito mosamala kwambiri, chifukwa mankhwalawo ali ndi zambiri zotsutsana.

Dziwani kuti kusankha kolakwika kwakanthawi kungapangitse kuti thupi la munthu lisayankenso insulin yomwe imapanga payokha. Ndipo izi, posachedwa, zidzatsogolera kukukula kwa matenda ashuga. Ndipo izi zitha kuchitika ngakhale mutakhala kuti simunayang'anitsidwe ndi matenda oopsa ngati amenewa.

Palibe chifukwa osatenga mankhwalawa "Glyukofazh" (mtengo wa nega umasiyanasiyana madera mazana awiri kapena mazana anayi) ngati mwazindikira chidwi ndi zomwe zimapezeka. Komanso, musamwe mankhwalawa kuti muchepetse thupi ngati muli ndi matenda amtima komanso ma mtima. Zachidziwikire, simungagwiritse ntchito mankhwala a ana, komanso azimayi oyembekezera komanso oyembekezera. Simuyenera kuigwiritsa ntchito ngati mukudwala matenda omwe ali pachimake pakukula. Komanso, musayese thanzi lanu ngati mukudwala matenda ashuga. Mwachitsanzo, musagwiritse ntchito mankhwalawa kuchiza matenda a shuga 2 ngati muli ndi matenda ashuga 1.

Glucophage: mavuto

Musaiwale kuti chida ichi chinapangidwira makamaka kuti chikhale ngati wodwala akudwala matenda ashuga. Mankhwalawa ndi akulu kwambiri, chifukwa chake ali ndi mndandanda waukulu wazotsatira zoyipa. Nthawi zambiri, odwala omwe amamwa mankhwalawa makamaka kuti achepetse thupi amadandaula za zotsatira zoyipa zamagetsi. Nthawi zambiri pamakhala mseru komanso kusanza, komanso kutsegula m'mimba, kapena, kudzimbidwa. Ngati mukuwona kuti mudayamba kuvutika chifukwa cha kuchuluka kwa mpweya m'matumbo, ndiye kuti mumadya chakudya chochuluka kwambiri. Pankhaniyi, muyenera kusintha zakudya zanu momwe mungathere.Ngati mukuwona nseru, ndiye kuti mankhwalawa amasankhidwa molakwika. Muyenera kuti muchepetse.

Nthawi zambiri limodzi ndi zoyipa kumayambiriro kwa chithandizo, kumwa mankhwalawa "Glucofage" kuwonda. Ndemanga za madotolo ndi odwala akufotokozedwa pansipa, ndipo muyenera kuzidziwa bwino musanayambe kumwa mankhwalawa. Komabe, patatha masiku ochepa, wodwalayo amayamba kumva kuti ndi wabwinobwino.

Nthawi zina, matenda a lactic acidosis amatha kuyamba. Amayamba chifukwa cha kusokonezeka kwa lactic acid metabolism m'thupi. Zimadzipangitsa kukhala ngati kusanza kosalekeza ndi mseru. Nthawi zina pamakhala zowawa m'mimba. Nthawi zambiri, odwala amayamba kusiya kuzindikira. Potere, kumwa mankhwalawa kuyenera kuyimitsidwa mwachangu. Kuti athetse mawonekedwe owoneka bwino, madokotala nthawi zambiri amapereka mankhwala othandizira. Chonde dziwani kuti kugwiritsa ntchito mosayenera komanso mosasamala mankhwala omwe ali ndi metformin kukhoza kuwononga thanzi lanu. Chifukwa chake, mugwireni ndi udindo wonse. Mlingo wowonjezereka wa metformin ungayambitse njira zina zosasintha zomwe zimachitika mu ubongo.

Malangizo Ofunika

Ngati mukuganiza kumwa mankhwala "Glucofage" kuti muchepetse thupi, mulingo woyenera uyenera kukhala wochepa. Komanso, ngati simutsatira mfundo za zakudya zoyenera, ndiye kuti simungathe kudalira zotsatira zabwino. Muyenera kupatula zakudya zomwe zili ndi chakudya chambiri kuchokera kuzakudya zanu. Choyamba, maswiti ndi zipatso zouma ziyenera kutchulidwa apa.

Komanso musayese kudya phala la mpunga, mbatata ndi pasitala. Palibe chifukwa choti musakhale pachakudya chamafuta ochepa, pomwe mumadya zosakwana kilositeti chikwi. Dziwani kuti Glucophage ndi mowa sizigwirizana kwathunthu. Koma mutha kugwiritsa ntchito zonunkhira ndi mchere mulingo uliwonse. Palibe zoletsa zapadera kwa iwo.

Kodi ndingachite masewera ndikumwa mankhwala ochepetsa thupi?

Mpaka posachedwa, madokotala adanenanso kuti mukamachita masewera, muthana ndi zotsatira zonse za kumwa mapiritsi a Glucophage. Komabe, chifukwa cha kafukufuku waposachedwa, asayansi adazindikira kuti kuchita masewera olimbitsa thupi ndikukhalabe ndi moyo wogwira ntchito, m'malo mwake, imathandizira njira yochepetsera thupi kangapo. Ngakhale odwala omwe amamwa mankhwalawa Glucofage mumiyeso yaying'ono kwambiri ndikusewera masewera amasangalala kwambiri ndi zotsatira zake. Musaiwale kuti metformin imalimbikitsa kutuluka kwa glucose mwachindunji kumisempha minofu. Chifukwa chake, pochita masewera olimbitsa thupi, mumawotcha chakudya chonse chomwe mumadya. Kupanda kutero, glucose, posachedwa, imasandukanso mafuta osungidwa m'thupi lanu. Ngati mukuganiza zopanga kuchepa thupi mothandizidwa ndi mankhwalawa, onetsetsani kuti mwapanga dongosolo la masewera olimbitsa thupi, komanso kuwerenganso zakudya. Ndipo zotsatira zabwino sizitenga nthawi yayitali.

Ndemanga za madotolo za mankhwala "Glucofage"

Apanso, ndikofunikira kubwereza kuti mankhwalawa adapangidwa kuti azitha matenda a shuga a 2. Mankhwala "Glucophage" ndiwofunika kwambiri, chifukwa chake popanda chifukwa chomveka sichikulimbikitsidwa. Mpaka pano, akatswiri sanapeze malingaliro osatsutsika pakugwiritsa ntchito mapiritsi azakudya izi. Komabe, kuwunika kwa madotolo ambiri kumawonetsa kuti mapiritsi amathandiziradi kuti achepetse thupi popanda kuwononga thanzi. Koma ndikofunikira kulingalira kuti ambiri ogwira ntchito zachipatala amaletsa kumwa mapiritsi a Glucofage kwa anthu omwe alibe matenda a shuga. Ngakhale kupatuka pang'ono panjira kungayambitse kuphwanya thupi m'thupi, zomwe zimayambitsa matenda ashuga.

Masiku ano, m'maiko ambiri, maphunziro apadera azachipatala amachitidwa, cholinga chake ndikupeza umboni wa chitetezo cha mankhwala omwe ali ndi metformin. Chifukwa chake, zotsatira za kafukufuku wotere zikuwonetsa kuti gawo ili limakulitsa kuchuluka kwa moyo osati kokha mwa odwala omwe ali ndi matenda a shuga, komanso mwa anthu omwe alibe matenda oterewa. Kuphatikiza apo, metformin imatha kuchepetsa kukalamba mthupi la munthu, zomwe ndi nkhani yabwino.

Ndemanga za odwala omwe amamwa mapiritsi kuthana ndi kunenepa kwambiri

Anthu omwe amagwiritsa ntchito Glucofage, omwe mawonekedwe ake ndi kukhalapo kwa metformin, sikuti nthawi zonse amakhala olimba pakugwiritsa ntchito mankhwala oopsa. Anthu ambiri sadziwa cholinga chake chenicheni ndipo amagwiritsa ntchito mapiritsi ngati chakudya pothandizidwa ndi anzawo ndi anzawo. Koma anthu ambiri ali okondwa kwambiri ndi zotsatirapo zake. Tikutenga mulingo wocheperako (500 mg patsiku), mutha kuwona momwe kulemera kwake kumachoka pang'onopang'ono. Odwala amatsimikizira kuti kulakalaka kumabwera nthawi zambiri, ndipo mapaundi owonjezera amapita.

Komabe, anthu ena amawona kuti ngakhale kulemera kukucheperachepera, kumakhalabe kwapang'onopang'ono. Mwezi umodzi mutha kutaya pafupifupi ma kilogalamu awiri kapena atatu okha. Komabe, malinga ndi ogwira ntchito pachipatala, ndiye kuti zolemerazi ndizomwe zimawonedwa ngati zabwino. Ndikofunika kwambiri kuti musamangoganiza nokha. Mapiritsi a Glucophage angagulidwe ku mankhwala aliwonse popanda mankhwala a dokotala, ndipo uwu ndi vuto lawo lalikulu. Ngakhale mutakhala otsimikiza kuti palibe chomwe chidzakuchitikireni mukatha kumwa mankhwalawa, onetsetsani kuti mwakumana ndi dokotala. Ndiye amene adzatha kuwerengera magawo anu onse akuthupi ndikusankha mulingo woyenera kwambiri. Katswiri wodziwa bwino yekha ndi amene angakuuzeni momwe mungatenge Glucophage.

Pali gulu la anthu omwe amagwiritsa ntchito mapiritsi otere kuti apange minofu. Dziwani kuti simupeza zotsatira zabwino pankhaniyi, chifukwa mankhwalawa amagwira ntchito pamfundo ina yosiyana.

Musanagule mapiritsi oterowo, konzekerani kuti zotsatira za kuchepetsa thupi sizimachitika konse. Odwala ena sasangalala kwambiri ndi mapiritsi awa. Zotsatira zoyipa zimawonekera motsutsana ndi kumbuyo kwawo, ndipo nthawi zina kunenepa kwambiri sikucheperachepera, koma kunkakulirakulira. Odwala omwe ali ndi matenda osiyanasiyana pachimake, akumamwa mapiritsi a Glucofage, adazindikira kuwonongeka kwa thanzi lawo. Komanso, anthu omwe sanatsatire zakudya zoyenera ndikumwa mowa amadzimva kwambiri.

Ambiri ali ndi chidwi ndi funso la kuchuluka kwa kumwa Glucofage. Dokotala wopezekapo angakuuzeni za izi. Nthawi zambiri, mankhwalawa amaledzera m'magulu, omwe muyenera kupuma. Ubwino wosakayikira wa mankhwalawa ndiwotsika mtengo kwambiri, komanso mwayi wogula pa mankhwala aliwonse. Ichi ndichifukwa chake mapiritsi a Glucophage akufuna kwambiri. Kupatula apo, chotsatira chabwino chitha kupezeka mukamawononga ndalama zochepa.

Ganizirani za thanzi lanu masiku ano. Kunenepa kwambiri si sentensi. Anthu ambiri amakhala ndi moyo wosayenera, chifukwa chake amakhala onenepa kwambiri. Sinthani moyo wanu lero. Yambani kudya kumanja, pitani m'masewera, pezani nthawi yambiri - ndipo mudzazindikira momwe kulemera kwanu pang'onopang'ono kumakhalira kwabwinobwino. Izi zitha kuchitika popanda kumwa mankhwala oopsa. Khalani athanzi ndipo samalani!

Contraindication

Glucophage (malangizo ogwiritsira ntchito omwe adatsekedwa phukusi) ali ndi zoletsa kugwiritsa ntchito.

Main contraindication ndi:

• chidwi chapadera ndi zigawo za metformin,
• kuphwanya kagayidwe kazakudya chifukwa chosowa insulin,
• chikomokere - chifukwa chosowa kwambiri insulin m'magazi,
• matenda oopsa a m'mapapo
• matenda a chiwindi,
• hepatic encephalopathy,
• kuphwanya kagayidwe kamchere wamadzi impso iliyonse,
• kupsinjika kwakukulu
• kuchepa chitetezo chokwanira
• nthawi yantchito
• Mimba ndi kuyamwa
• uchidakwa
• MRI mosiyanitsa (Glucofage yathetsedwa masiku angapo asanachitike ndi pambuyo pake),
• kudzikundikira kwa lactic acid mthupi (cholembedwa kamodzi).

Izi zotsutsana ndizotsimikizika. Chowonjezera chodziwikiratu ndikuchiritsa kwa hypoglycemic, komwe kumachepetsa shuga la magazi.

Gwiritsani ntchito panthawi yoyembekezera komanso poyamwitsa

Mimba popeza deta yodalirika yamankhwala amakono okhudzana ndi kugwiritsa ntchito glucophage pa nthawi ya pakati sikokwanira, Mimba ndi kutsutsana kwathunthu.

Mayeso azachipatala omwe adachitika mu labotore ndi osangalatsa pazowumaliza. Sizikutsimikiziridwa kuti kusokonekera komwe kumachitika mwa mwana wosabadwayo ndi chifukwa chotenga metformin kapena zifukwa zina.

Choyamwa: Metformin kapena Glucofage pafupifupi simalowa mkaka wa m'mawere. Koma palibe chidziwitso chokwanira chofufuzira, sizikudziwika kuti ndi gawo liti la mankhwalawa lomwe mwana adzalandire, pachifukwa ichi malangizo a mankhwalawa akuwonetsa zoletsedwa kumwa mankhwalawa pakudya, zomwe zimatha kukhala chitetezo kwa moyo wa mwana ndi mayi.

Malangizo ogwiritsira ntchito

Glucophage (malangizo ogwiritsira ntchito amafotokozera manenedwe onse ogwiritsira ntchito mankhwalawa) amaperekedwa m'magulu osiyanasiyana a anthu. Awa ndi akulu, ana opitirira zaka khumi, anthu okalamba. Ndi matenda osiyanasiyana osachiritsika, kuchuluka kwa mankhwalawa ndi mitundu yake.

Mukamagwiritsa ntchito mtundu umodzi wokha wa mankhwalawa, osaposa 0,5 g kapena 0,85 g wa mankhwalawa amatchulidwa ngati mlingo woyambirira m'mawa ndi madzulo pambuyo pa maola 12.

Ngati palibe zoyipa, ndiye kuti patatha milungu iwiri mlingo wa mankhwalawa umasinthidwa, mogwirizana ndi zotsatira zake. Mutha kuchepetsa kuchuluka kwa mankhwala omwe amamwa ngati mayeso a glucose akuwonetsa kuchepa kwakukulu, kapena kuonjezeka pamene kuchuluka kwa Glucofage sikokwanira kuthana ndi glucose wokwera m'magazi.

Mlingo wa mankhwalawa nthawi zambiri umachulukana pang'onopang'ono, apo ayi ma hypoglycemia komanso mawonekedwe osafunikira ochokera m'mimba ndi matumbo amatha kupweteka. Mlingo woyenera wovomerezeka ndi madokotala ndi 3 g mkati mwa maola 24, wogawidwa kokwanira kuchuluka kwa zakudya. Mwachitsanzo, ngati chakudya 5 chimatengedwa patsiku - Glucophage imatengedwa kangapo patsiku ndi chakudya.

Kugwiritsa ntchito glucophage ndi insulin

Kuti muchepetse kuchuluka kwa shuga, pangafunike kuphatikiza glucophage ndi insulin. Mlingo woyambira wa metformin ndi 0,5 g kapena 0,85 g wa mankhwalawa kawiri patsiku, atatha maola 12. Kuchuluka kwa insulini kumasankhidwa potengera zotsatira za kuyesa kwa shuga.

Kugwiritsa ntchito glucophage kumaloledwa kwa ana azaka 10. Mlingo woyambira umachokera ku 0,25-0.85 g wa mankhwalawa kamodzi patsiku. Mankhwala amatengedwa ndi chakudya. Patatha milungu iwiri, kutengera zotsatira za mankhwala, kuchuluka kwa mankhwalawa kumatha kusintha.

Mlingo wa Glucofage onse umachulukitsidwa ndikuchepetsedwa pang'onopang'ono kotero kuti palibe kudumpha kwadzidzidzi mu glucose kapena mawonekedwe owoneka kuchokera m'mimba.

Mlingo waukulu kwambiri wa ana ndi 2 g ya mankhwalawa patsiku, omwe amagawidwa ndi kuchuluka kwa zakudya.

Odwala omwe ali ndi matenda a impso

Glucophage (malangizo ogwiritsira ntchito amalola kumwa mankhwalawo kuti mupeze vuto ndi impso) matenda a impso, poganizira zoletsa - mulingo wa creatinine uyenera kukhala wovomerezeka 0,4-0.6 μmol / l.

Kuchuluka kwa Glucophage kwa anthu otere ndi 0.5-0.85 g kamodzi patsiku ndi chakudya. Mulingo waukulu wa mankhwalawa patsiku ndi 1 g patsiku, womwe umagawidwa kawiri pakatha maola 12.Pakadutsa miyezi iwiri ndi iwiri, ndikofunikira kuwunika momwe impso zimayendera. Ngati ndi kotheka, kugwiritsa ntchito glucophage kumayima.

Glucophage kuwonda

Glucophage imatengedwa ndi kulemera kwakukulu, chifukwa, malinga ndi malangizo ogwiritsira ntchito, amathandizira kuchepetsa kuchuluka kwa cholesterol yoyipa, triacylglycerides ndi lipoproteins m'thupi. Zosakaniza zomwe zimagwiritsidwa ntchito ku Glucophage zimathandizira kuti shuga azichulukitsa komanso zimachepetsa kupanga kwa insulin. Izi zimathandiza kuchepetsa subcutaneous mafuta.

Mfundo za ntchito Glucofage ndi owonjezera kulemera:

• kuyamwa kwa glucose kumachepera - chomwe chimayambitsa mapaundi owonjezera,
• mafuta acids, omwe amapereka maselo amthupi ndi mphamvu, amawonongeka mwachangu
• ntchito ya proteinasease imayendetsedwa (yothandizira mphamvu yama cell),
• gluconeogenesis (kaphatikizidwe ka glucose) yafupika,
• zakudya zimaperekedwa mofulumira ku minofu,
• insulin sensitivity bwino.

Asayansi atsimikiza kuti mukamadya chakudya, kuchuluka kwa glucose m'thupi kumachuluka, zomwe zimapangitsa kuti insulini iwonjezeke. Ngati kuchuluka kwa zakudya zomwe zimadyedwa sikuyendetsedwa, ndiye kuti izi zimabweretsa kuphwanya njira za kagayidwe kachakudya mthupi komanso kudziunjikira kwambiri mafuta m'thupi.

Mankhwala ozikidwa pa metformin amagwiritsidwa ntchito kuti achepetse kulemera, koma kuti athandize kuchepetsa thupi, mfundo za kadyedwe ziyenera kutsatiridwa. Ndikofunikira kuti muchepetse kuchuluka kwa shuga ndi ufa woyera (m'mitundu yonse).

Momwe mungatengere glucophage kuti muchepetse kunenepa

Pali mitundu ingapo ya mankhwala a Glucophage:

1. Tsiku lililonse, katatu musanadye, 0,5 g. Kuwoneka kwa zoyipa kumatha kuwonetsa kuti mulingo wambiri - pali kufunika kochepetsa theka ndi theka. Tengani mankhwalawa masiku 20 mpaka 1 mwezi. Kenako amapuma mpaka miyezi itatu.
2. Mulingo woyenera kwambiri wa metformin ndi 1.5-2 g patsiku. Ngati palibe zotsatirapo zabwino ndi kuchuluka kwa mankhwalawa komanso momwe zinthu zonse zalandiridwira, muyenera kuwonjezera kuchuluka kwa mankhwalawa mpaka 3. Koma simungathe kutenga Glucophage mwambiri. Chipangizocho chikuyenera kutsukidwa ndi madzi okwanira (osakhala ndi kaboni).
3. Glucophage Yaitali. Mwanjira imeneyi, mankhwalawa amatengedwa kawiri kokha patsiku. Izi zikuthandizira kuchepetsa kufunitsitsa kudya usana ndi usiku. Glucophage nthawi yayitali imangotengedwa muyezo wa 0,5 g ndi 0,85 g.
4. Glucophage mu gawo la 1 g amathanso kutengedwa kuti muchepetse kunenepa. Kutengera umunthu wa thupi, ndizotheka kumwa mankhwalawa kamodzi patsiku kapena kuposerapo. Koma mlingo wa tsiku ndi tsiku sayenera kupitirira 3 g.

Mkhalidwe wofunika kwambiri wazotsatira zabwino zogwiritsa ntchito Glucofage kulimbana ndi kunenepa kwambiri ndi kukanidwa kwa mafuta osavuta (kapena kumwa kwawo kochepa).

Malangizo apadera ndi kusamala

Mukamagwiritsa ntchito Glucofage, pali kufunika kosamala:

1. Lactic acidosis - Ichi ndi mkhalidwe wa momwe lactic acid imadziunjikira m'thupi la munthu, yomwe imayambitsa kukomoka. Kuchita kotereku kumatha kuyamba ndi Glucophage pokhapokha ngati munthu ali ndi vuto la impso. Kuphatikiza apo, zimatha chifukwa cha kuchepa kwa mpweya m'thupi, ziwalo ndi minofu minofu. Chomwe chimapangitsa izi ndi kumenya kwa nthawi yayitali, kumwa mowa mwauchidakwa komanso kugwiritsa ntchito mankhwala osokoneza bongo, komwe kumachitika limodzi ndi kupumira mwachangu, kukokana kwam'mimba, komanso kutsika kwa kutentha kwa thupi.
2. Opaleshoni. Chithandizo chamtunduwu chimangofunika kusiya kugwiritsa ntchito metformin masiku awiri asanafike komanso masiku awiri atamuchita opaleshoni.
3. Ntchito ya impso. Glucophage kuchokera mthupi imachotsedwa kudzera mu impso, chifukwa chake, kuyang'anira ntchito ya impso kumafunika: kamodzi pachaka - ndi yachibadwa ntchito impso. Kotala lililonse - ngati creatinine ali pansi pa 40 µmol / L.
4. Zaka za ana. Sizitsimikiziridwa mwasayansi kuti glucophage pochiza ana opitirira zaka 10 sizikhudza kukula kwa thupi ndi kugonana. Chifukwa chake, kuyang'anira kumafunikira. Pogwiritsa ntchito metformin pochiza ana, ndikofunikira kuwongolera kukula konse ndi magawo a kusasitsa.
5. Kutsatira Kovomerezeka mfundo zachakudya.
6. Pakufunika kuyezetsa shuga, makamaka kwa anthu omwe amatenga Glucophage ndi insulin.
7. Mayendedwe ndi njira. Mitundu iyi ya ntchito sikuletsedwa mukamagwiritsa ntchito metformin. Koma kusamala kuyenera kugwiritsidwa ntchito, chifukwa munthu aliyense akhoza kuchitapo kanthu pa mankhwalawo.

Madokotala amafufuza

Malingaliro a madokotala okhudzana ndi mankhwalawa Glucophage nthawi zambiri amakhala abwino. Kwenikweni, Glucophage yadzikhazikitsa yokha ngati njira yothanirana ndi kunenepa kwambiri komanso mankhwala omwe amachepetsa mphamvu ya glucose pakadumphika.

Pali malingaliro a madokotala kuti Glucophage imathandizira kulimba kwa amuna, komanso amachepetsa kukalamba kwa thupi. Pali maphunziro a labotale otsimikizira izi za glucophage pa thupi la munthu.

Ndemanga zakuchepetsa thupi kuchokera kumisonkhano

Mu malangizo ogwiritsira ntchito, malingaliro a odwala omwe akutenga Glucophage sakuperekedwa, ndipo pakati pawo pali osiyana kwambiri, onsewo akutsimikizira zotsatira zabwino za Glucophage ndikuwadzudzula chifukwa chachabe komanso ngakhale zotsutsana.

Mwachitsanzo, pali umboni kuti Glucophage amathandizira kuchepetsa thupi mukatha kubereka. Mutha kutaya makilogalamu 10 m'miyezi itatu. Izi zitha kukhala zokwanira ndi kulemera kwapakati pa nthawi ya pakati kuti mubwererenso kunenepa.

Chifukwa cha Glucofage, mutha kuchepetsa thupi.

Malinga ndi ndemanga ina, kumwa mankhwalawo sikuti kunangothandiza kuti muchepetse thupi, komanso kunapangitsa kuti munthu azichita kunenepa kwambiri, zomwe zimatipangitsa kuti tikambirane za kudalira kwa zomwe mankhwala amapanga pamaonekedwe a thupi.

Kuchita ndi mankhwala ena

Pali zotsutsana mwamtheradi kuphatikiza kwa glucophage ndi mankhwala ena, kuyanjana kosafunikira komanso zomwe zimafuna chidwi chochulukirapo.

Malangizo apadera kwa iwo:

1. Zopanda malire kwathunthu. Kuchita uku kumaphatikizapo MRI ndikukhazikitsa kwa wotsutsana naye. Pankhaniyi, kuchuluka kwa lactic acid ndikotheka, komwe kumayambitsa kukomoka. Ngati izi zikufunika, metformin idathetsedwa masiku awiri kale ndipo simunatenge masiku awiri atatha.
2. Zosafunika. Mowa wophatikiza ndi Glucofage ukhoza kuchitika chifukwa cha zolakwika zilizonse, ngati sichoncho pa chinthu chimodzi: kuchuluka kwa asidi lactic kumangokulira kokha ndi kuledzera kwambiri komanso ndi m'mimba yopanda kanthu. Mankhwala okhala ndi Ethanol nawonso ndi osayenera.

Imafunika chidwi:

• spiranolactone - osavomerezeka kuti agwiritsidwe ntchito ndi metformin. Kuphatikizika kumeneku, m'malo mwake, kumawonjezera kuchuluka kwa shuga m'magazi,
• chlorpromazine yambiri imakweza kuchuluka kwa shuga m'magazi. Kusintha kwa mlingo woyenera
• glucocorticoids (chilichonse) chimayambitsa matenda a prediabetes, kuwonjezera shuga. Kuyang'anira shuga komanso kusintha kwa metformin,
• okodzetsa. Kuphatikiza kwa furosemide ndi Glucofage nthawi zambiri kumabweretsa kuwonjezeka kwa lactic acid chifukwa cha pathologies ndi impso,
• jakisoni wa blockers amawonjezera shuga mu thupi. Kuwongolera shuga. Ngati ndi kotheka, phatikizani ndi insulin,
• calcium blockers blocker kumawonjezera mayamwidwe ndi kusunga glucophage m'thupi,
• narcotic analgesics. Kuphatikizika kwa Glucophage ndi mankhwalawa kumawonjezera mphamvu yamapeto a thupi.

Kodi ndingathe kumwa ndi mowa

Kugwiritsira ntchito pamodzi kwa metformin ndi zakumwa zoledzeretsa sikuvomerezeka. Choyamba, chifukwa cha kutukuka kwa lactic acidosis ndipo, chifukwa chake, chikomokere.Kachiwiri, kusakaniza kwa glucophage ndi mowa kumawonjezera ntchito ya chiwindi. Makamaka ngati thupi ili kale ndi zotupa.

Mowa wa Ethyl wophatikizana ndi Glucofage ungachepetse shuga m'magazi kuti akhale ochepa. Izi ndizodzaza ndi hypoglycemic coma, zizindikilo zomwe sizingasiyanitsidwe ndi kuledzera ndikuyamba kufa.

Zotsatira zoyipa

Glucophage imabweretsa mavuto:

1. Njira za metabolism - lactic acid imatha kudziunjikira. Mafuta a cobalamin (B12) ndi opuwala.
2. Neurology ndikuphwanya masamba a zipatso.
3. Mimba thirakiti - kumasuka kwa chopondapo, kulimbikitsa kusanza, kunachepetsa chilimbikitso.
4. Khungu - thupi lawo siligwirizana monga zotupa ndi zotupa, erythema.
5. Dongosolo la biliary ndikuphwanya magawo a ziwindi za chiwindi.

Zotsatira zake pamwambapa zimatha nthawi yomweyo atasiya kumwa mankhwalawo.

Zizindikiro zochuluka

Zowonetsa zazikuluzikulu za bongo zimaphatikizira lactic acidosis, mkhalidwe womwe lactic acid imakwera kwambiri.

Imadziwulula ndi zizindikiro monga:

• kupweteka kwambiri pamimba
• kusanza kosamveka
• kupweteka kwa minofu.

Vutoli limafunikira kuchipatala kuchipatala.

Moyo wa alumali ndi malo osungira

Alumali moyo wa mankhwala ndi nthawi yomwe makonzedwe ake amakhala otetezeka. Mlingo wa 0,5 g ndi 0,85 g, alumali moyo wafika zaka zisanu, pa mlingo wa 1 g - mpaka zaka zitatu. Moyo wa alumali ndi wolondola ngati kutentha kosungirako kumawonedwa - kuchokera 20 mpaka 25 digiri Celsius.

Mtengo wa glucophage umatengera mlingo komanso kuchuluka kwa mapiritsi omwe ali phukusi. Mtengo wa mankhwalawa umasiyana ndi ma ruble 120. phukusi lililonse (0,5 g - mapiritsi 30) mpaka ma ruble 750. phukusi lililonse (1 g - mapiritsi 60).

Analogi a njira

Glucophage imakhala ndi ma genetic kapena mankhwala omwe ali ndi vuto lofananalo ndi chinthu chachikulu chogwira ntchito:

1. Bagomet - woimira pakamwa hypoglycemic mankhwala. Amakhala ndi Glucofage komanso zotumphukira za sulfonylurea. Mtengo umatengera Mlingo ndipo umachokera ku ma ruble 130. mpaka 200 rub.
2. Glyformin - m`kamwa mankhwala a pharmacological gulu la dimethyl beguanides, kumawonjezera kuchotsedwa kwa zosavuta mafuta m'thupi, linalake ndipo tikulephera mayamwidwe chakudya mu matumbo. Mtengo wa mankhwalawa umachokera ku ma ruble 110. mpaka 350 rub.
3. Siofor - mawonekedwe amkamwa a glucophage kapena analogue. Mankhwala amathandizira kuchepetsa triglycerides ndi lipoproteins. Poyerekeza ndi kumbuyo kwa kutenga Siofor, kunenepa kwambiri kumataika. Mtengo wa mankhwalawa umachokera ku ma ruble 270. mpaka 370 rub.
4. Metformin - mawonekedwe mkamwa. Muzipatala, mumagwiritsa ntchito mankhwalawa mosiyanasiyana. Awa ndi magazi ochepetsa shuga. Zimathandizira kumakonzedwe a mafuta oxidation. Mtengo wa mankhwalawa umachokera ku ma ruble 10. mpaka ma ruble 200, zomwe zimatengera mlingo.

Mankhwala "Glucofage", omwe amawongolera kuchuluka kwa shuga m'thupi, samatengedwa pokhapokha ngati pali matenda a shuga, komanso pamaso pa kunenepa kwambiri kuti muchepetse kunenepa. Mukamamwa mankhwalawa, ndikofunikira kutsatira malangizo ogwiritsira ntchito osachulukitsa mlingo wowonjezera pazomwe mumakonda. Glucophage imakhala ndi zovuta zoyipa, zomwe zimaphatikizira bongo.

Kapangidwe kake: Oksana Grivina

Limagwirira a zochita za glucophage

Mankhwala Glucophage amawonetsedwa m'masitolo amitundu amtunduwu: Glucofage 500, Glucofage 850, Glucofage 1000 ndi mitundu yowonjezeredwa - Glucofage yayitali. Ubwino wosakayika wa mankhwala ozikidwa pa metformin umaphatikizapo mtengo wotsika mtengo. Kupanga kwake kwa mankhwala kumveka bwino.

Maziko ake ndi momwe amapangira mamolekyulu atsopano a glucose m'chiwindi. Mu shuga mellitus, njirayi imakulitsidwa nthawi 3 poyerekeza ndi chizolowezi. Glucophage poyambitsa ma enzyme angapo amaletsa gluconeogeneis.

Kuphatikiza apo, odwala omwe ali ndi glucofage amalimbikitsa chidwi cha minofu kuti insulin (makamaka minofu minofu). Mankhwala amalimbikitsa kulumikizana kwa insulin ndi ma receptor m'magazi ofiira, ma hepatocytes, maselo amafuta, myocyte, kukulitsa kuchuluka kwa kulowa kwa glucose mwa iwo ndi kukodwa kwake kuchokera m'magazi.

Kutsika kwa mapangidwe a shuga m'chiwindi kumayambitsa kutsika kwa kudya kwa glycemia, ndipo kuletsa kwa kuyamwa kwa mafuta mu lumen ya m'matumbo ang'ono kumayambitsa nsonga yowonjezera kuchuluka kwa shuga wamagazi atatha kudya. Glucophage imatha kuchepetsa kuthamanga kwa m'mimba ndikuwonjezera mphamvu ya matumbo ochepa.

Nthawi yomweyo, makutidwe ndi okosijeni amafuta achilengedwe amakwera, cholesterolemia, mlingo wa triglycerides ndi atherogenic lipids amachepa. Zotsatira zonsezi zimachitika pokhapokha ngati insulin ili m'magazi.

Chifukwa cha chithandizo cha Glucofage, zotsatirazi zimadziwika:

• Kuchepa kwa glycemia ndi 20%, hemorrhea wambiri ndi 1.54%.
• Chiwopsezo cha myocardial infarction, kufa kwathunthu kumachepetsedwa.
• Akapatsidwa gawo la prediabetes, matenda a shuga amayamba pafupipafupi.
• Kuchulukitsa chiyembekezo cha moyo komanso kumachepetsa chiopsezo chotupa chotupa (zoyesa deta).

Glucophage imayamba kugwira ntchito mkati mwa maola 1-3, ndi mitundu yowonjezera (Glucofage yayitali) maola 4-8. Njira yokhazikika imawonedwa kwa masiku awiri ndi atatu. Zinadziwika kuti chithandizo cha metformin sichimatsogolera ku vuto la hypoglycemic, chifukwa sichimatsitsa mwachindunji shuga m'magazi, koma imaletsa kuchuluka kwake.

Glucophage ndiye mankhwala oyamba a metformin, chifukwa chake amagwiritsidwa ntchito pofufuza. Mphamvu ya Glucophage pa chiwongolero cha matenda a shuga 2, komanso kuchepa kwa chiwopsezo cha matenda, makamaka mtima.

Glucophage wa matenda ashuga a 2

Chizindikiro chachikulu chogwiritsa ntchito mankhwalawa ndi mtundu wachiwiri wa shuga kuphatikiza kunenepa kwambiri, cholesterol yayikulu m'magazi, komanso kulemera kwakanthawi kwamthupi. Odwala ena omwe ali ndi matenda ashuga samaloleza kukonzekera kwa sulfonylurea, kapena kukana nawo, Glucofage imatha kuthandiza gulu ili la odwala.

Komanso, metformin ikhoza kuphatikizidwa kuti iphatikizidwe ndi mankhwalawa ndi insulin ya matenda a shuga 1, komanso kuphatikiza kosiyanasiyana ndi mankhwala ochepetsa shuga m'mapiritsi a matenda a shuga a 2.

Ndimasankha mlingo wa Glucophage payekha, motsogozedwa ndi glycemia. Mlingo umodzi ndi 500-850 mg, ndipo tsiku ndi tsiku ndi 2,5 mpaka 2-3 Gawo lothandiza la odwala ambiri ndi 2-2.25 g.

Chithandizo chimayamba ndi mlingo wochepa - 500 mg patsiku, ngati ndi kotheka, muwonjezeke ndi 500 mg ndi gawo la masiku 7. Mlingo wambiri (kupitirira 3 g) samabweretsa kusintha kwa kagayidwe kakang'ono ka shuga. Nthawi zambiri, glucophage imatengedwa katatu patsiku.

Popewa zovuta m'matumbo, mankhwalawa amalimbikitsidwa kuti amwe pakudya kapena mutatha kudya.

M'pofunika kuganizira kuchepa kwa Glucophage, omwe mankhwala ena ochepetsa shuga alibe - kuteteza kwa shuga m'magazi a m'mawa. Kuti mugwiritse ntchito chinthu chapaderachi mpaka pazambiri, muyenera kutenga glucophage musanagone.

Kupititsa patsogolo kagayidwe kachakudya kumawonekera pakatha masiku 7-10, ndipo kuchuluka kwa shuga m'magazi kumayamba kutsika pakatha masiku awiri. Pambuyo pa kubwezeretsedwa kwa hyperglycemia ndikwaniritsidwa bwino, mutha kuyesa kuchepetsa pang'onopang'ono mlingo wa mankhwalawa popenyerera shuga wamagazi.

Mankhwala otsatirawa amagwiritsidwa ntchito:

1. Glucophage + Glibenclamide: amagwiritsa ntchito njira zosiyanasiyana pokopa glycemia, onjezerani zochita za wina ndi mnzake.
2. Glucophage + Insulin: kufunikira kwa insulin kumachepetsedwa mpaka 25-50% ya zoyambirira, dyslipidemia ndi kukakamizidwa zimakonzedwa.

Kafukufuku wambiri wa matenda osokoneza bongo amatipangitsa kuti tiziganiza kuti insulini imayamba kudwala kale kwambiri kuposa momwe amayembekezera.Chifukwa chake, Glucofage ikulimbikitsidwa kugwiritsidwa ntchito pa mlingo wa 1 g patsiku, limodzi ndi zakudya komanso zolimbitsa thupi.

Prophylaxis yotere imachitika mwa odwala omwe ali ndi kunenepa kwambiri, kuchepa kwa chakudya chamafuta, mafuta ambiri, matenda oopsa komanso kutengera kwa makolo chibadwa chachiwiri.

Glucophage imathandiza kuthana ndi insulin kukana ndipo imachepetsa kwambiri zomwe zili m'magazi, kupewa mtima.

Glucophage wokhala ndi polycystic ovary

Polycystic ovary ndi insulin kukana kumawonetsedwa ndi kuchuluka kwachulukidwe kwamahomoni ogonana aamuna, kutalika kwa msambo ndi kusowa kwa ovulation, komwe kumapangitsa odwala kukhala osabereka.

Amayi nthawi zambiri amakhala onenepa kwambiri ndi polycystic ovary syndrome, amadwala matenda a carbohydrate kapena amatsimikizira matenda a shuga. Kugwiritsa ntchito Glucophage mu zovuta chithandizo cha odwala oterewa kumawongolera ntchito yobereka, nthawi yomweyo kumabweretsa kuchepa kwa thupi ndi kuphatikiza mawonekedwe a mahomoni.

Kugwiritsa ntchito Glucofage muyezo wa 1500 mg tsiku lililonse kwa miyezi isanu ndi umodzi kumachepetsa kuchuluka kwa insulin m'magazi, msambo umasinthidwa pafupifupi 70% ya azimayi.

Nthawi yomweyo, zotsatira zabwino za kapangidwe ka magazi zidadziwika: kuchepa kwa mafuta m'thupi ndi lipoproteins yotsika.

Glucophage zimakhudza kulemera

Ngakhale mankhwala ozikidwa pa metformin alibe chisonyezo chachindunji chogwiritsa ntchito kunenepa kwambiri, amagwiritsidwa ntchito kuchepetsa thupi, makamaka ngati pali kuphwanya kwa kagayidwe kazakudya. About ndemanga ya Glucofage yochepetsa thupi, zonse zabwino ndikuwonetsa kutsika kwake kochepa.

Maganizo osiyanasiyana - "Ndinachepa thupi pa Glyukofage ndipo ndinataya makilogalamu 6", "sindimachepetsa thupi, ngakhale ndimankhwala ochulukirapo", "Glyukofage yekha ndi amene amachepetsa thupi", "poyamba ndinachepetsa thupi pa Glyukofage, kenako kulemera kunayima", "Ndataya kilogalamu imodzi m'mwezi umodzi ", Sonyezani kuti mankhwalawa sangathandize aliyense.

Katundu wamkulu wa mankhwalawa, omwe amathandiza kuchepa thupi, ndikuwonjezereka kwa insulin, komwe kumapangitsa kuchepa kwa chinsinsi chake, popeza kuchuluka kowonjezereka sikuyenera kuthana ndi kukana kwa receptor. Kutsika koteroko kwa insulin m'magazi kumapangitsa kutsika kwamafuta ndikuthamangitsa kusunthika kwake.

Kuphatikiza apo, mphamvu ya Glucofage imadziwoneka pakumva njala, imachepetsa chilimbikitso, komanso kuletsa kuyamwa kwa matumbo m'matumbo ndi kuchotsedwa kwawo kwothamanga chifukwa cha kuchuluka kwa peristalsis kukapezeka mu chakudya kumachepetsa kuchuluka kwa zopatsa mphamvu.

Popeza Glucofage siyimayambitsa kutsika kwa shuga m'magazi pansi pazomwe zimakhalapo, kugwiritsidwa ntchito kwake ndikothekanso ndi glycemia, ndiye kuti, pamlingo wa kusokonekera kwa glucose kumatha kusokonezeka koyambirira kwa chakudya chamafuta ndi mafuta.

Pofuna kuti musakhale ndi zovuta za metabolic pamodzi ndi kuwonda, muyenera kuganizira mukamatenga Glucofage kapena Glucofage yayitali:

• Kumwa mankhwalawa sikutanthauza kuwonda.
• Zatsimikizika kufunika kwa kuchepa thupi kuphwanya kulekerera kwa chakudya chamthupi ndi hyperinsulinemia.
• Muyenera kutsatira zakudya.
• Sipayenera kukhala chakudya chamagulu m'zakudya.
• Mlingo umasankhidwa payekha - mlingo woyambirira ndi 500 mg kamodzi patsiku.
• Ngati kutsegula m'mimba kumachitika pambuyo pa kutsata, izi zikutanthauza kuti pali chakudya chamagulu ambiri.
• Ngati nseru ikuchitika, chepetsani kwakanthawi.

Omanga a thupi amagwiritsa ntchito metformin limodzi ndi maphunziro aerobic kuti atenthe mafuta. Kutalika kwa maphunzirowa ndi masiku 20, kenako muyenera kupuma kwa mwezi umodzi. Kugwiritsa ntchito mankhwalawa koletsedwa mosavomerezeka ndi dokotala.

Chifukwa chake, titha kunena kuti kuikidwa kwa Glucofage kungakhale koyenera kuchitira odwala omwe ali ndi vuto la mafuta m'thupi, omwe amaphatikizidwa ndi kuchuluka kwa insulin m'magazi komanso kukana kwa chiwindi, minofu ndi mafupipafupi a mafuta.

Naturalization ya kagayidwe kachakudya njira kumabweretsa kuwonda, malinga ndi zakudya zoletsa komanso zokwanira zolimbitsa thupi. Mankhwala sakusonyezedwa mankhwalawa kunenepa popanda kuyeserera koyambirira.

Nthawi zambiri, kuchepa thupi kumachepa, ndipo chiwopsezo cha kusokonezeka kwa metabolic ndi chambiri.

Zotsatira zoyipa za glucophage komanso kuvulaza thanzi

Zotsatira zoyipa kwambiri za Glucophage ndizovuta m'matumbo, chosasangalatsa pambuyo pake pakamwa, kutsekula m'mimba, matumbo a colic, nseru, ulemu. Zotsatira zosasangalatsa zotere za kumwa mankhwalawa zimadziwika m'masiku oyamba kugwiritsa ntchito Glucophage, kenako ndikungopereka okha, popanda chithandizo chowonjezera.

Ndi matenda otsekula m'mimba, mankhwalawa amatha. Thupi likazolowera, mphamvu ya metformin pamatumbo samamveka kwenikweni. Ndi kuchuluka pang'onopang'ono kwa mlingo, kusapeza bwino kungapeweke.

Kugwiritsa ntchito nthawi yayitali kwa Glucophage kumabweretsa chiwonetsero cha B12 hypovitaminosis: kufooketsa kukumbukira, kukhumudwa, kugona tulo. Ndizothekanso kukula kwa kuchepa kwa magazi m'thupi.

Popewa, tikulimbikitsidwa kuti mudye mavitaminiwa m'maphunziro pamwezi, makamaka ndi zakudya zamasamba.

Zotsatira zoyipa kwambiri za gulu la Biguanide, zomwe metformin yokha imagwiritsidwa ntchito, ndikupanga lactic acidosis. Ndi chifukwa chowopsa chitukuko chake kuti mankhwala otsala a gululi amachotsedwa pamsika wamankhwala. Vutoli limachitika chifukwa chakuti lactate imagwiritsidwa ntchito popanga shuga m'magazi, ndipo metformin imalepheretsa njira yotembenuka iyi.

Pa ntchito yachilendo impso, lactate yambiri imachotsedwa, koma ndimakonda kumwa mowa, kulephera kwa mtima, matenda am'mapapo kapena kuwonongeka kwa impso, lactic acid imadziunjikira, zomwe zimabweretsa mawonetsedwe:

1. Kupweteka kwa minofu
2. Ululu pamimba ndi kumbuyo kwa sternum.
3. Kuchepetsa mseru
4. Kupuma kwamphamvu.
5. Chisoni ndi kugona.

Milandu yayikulu, lactic acidosis imatha kukhala ndi vuto. Kuphatikiza apo, Glucophage imachepetsa kuchuluka kwa mahomoni olimbikitsa chithokomiro, ndipo mwa amuna - testosterone.

Metformin imaphatikizidwa matenda a impso, chiwindi ndi mapapu, uchidakwa komanso kulephera kwamtima, ketoacidosis, zovuta za matenda a shuga mellitus monga hyperosmolar kapena lactic acidosis chikomokere.

Mankhwala sinafotokozeredwe chakudya chochepa mphamvu ya calorie (pansi pa 1000 kcal patsiku), kuchepa magazi, pambuyo pa zaka 60, kuchita masewera olimbitsa thupi komanso nthawi yobereka.

Dr. Kovalkov kuchokera mu kanema munkhaniyi ayankhula za zabwino za Glucophage kwa anthu onenepa kwambiri.

Momwe mungatengere shuga komanso kuwonda

Glucophage iyenera kutengedwa mosalekeza kuti zotsatira zabwino zithe. Nthawi yomweyo, siyimachepetsa shuga mopitirira muyeso, siyimayambitsa hypoglycemia, ngati simuposa mlingo woyenera. Kodi ndiyenera kumwa mankhwalawa kwa nthawi yayitali bwanji? Momwe mungatenge musanatenge Glucofage yochepetsa thupi kapena motsutsana ndi matenda a shuga, werengani mosamala malangizo omwe angagwiritsidwe ntchito. Order Galvus meth 50 mg kuphatikiza 850 mg 30 mapiritsi a Novartis Singapore Pharmaceutical Menyufek 1880 rub.

Chizindikiro chogwiritsidwa ntchito ndi kupezeka kwa wodwala wa DM 2 yowonjezera mawu othandizira thermometer wotchi yotsika mtundu wa barometer. Site m imalimbikitsa kuti asinthane ndi katemera wa Galina Turkish kuti azitha kudya zakudya zamafuta ochepa, kuti kuwonda kwambiri kukhale kothandiza. Glucophage ndi mankhwala osokoneza bongo omwe amapangitsa kuti magazi azikhala ochepa. Ndikofunika kuyesedwa koyesa ntchito ya chiwindi ndi impso, komanso kufunsa dokotala. Zikatero, ndikotheka kudandaula kuti mankhwalawa ndi osokoneza bongo.

Kuchokera kwamanjenje: kawirikawiri - kugwedeza, chizungulire, kupweteka kwa mutu. Mankhwala a Glucophage ndi Glucophage Long amatha kuphatikizidwa ndi mankhwala ena a shuga ndi jakisoni wa insulin monga momwe dokotala wakunenera.Mukamagwiritsa ntchito mankhwala a Galvus muyezo wa 50 mg 1 kapena 2 kawiri pa tsiku limodzi ndi metformin: Mukamagwiritsa ntchito mankhwala a Galvus muyezo wa 50 mg patsiku limodzi ndi metformin, pafupipafupi pakulekana kwa mankhwalawa chifukwa chotukuka mosiyanasiyana. Mu kafukufuku woyesera, atalembedwa muyezo Mlingo 200% kuposa momwe analimbikitsira, mankhwalawa sanayambitse chonde ndikukula koyambirira kwa mwana wosabadwayo ndipo sanatanthauze mwana wosabadwayo. Ikaperekedwa, kuyamwa kwa vildagliptin kumachitika mofulumira. Mutha kuonjezera mlingo ndi 500 kapena 850 mg patsiku kamodzi pa sabata kapena masiku khumi ndi anayi, ngati wodwalayo angalekerere kulandira bwino chithandizo.

Galvus ndi Galvus Met

Kusiyana pakati pa Onglisa ku Galvus, onglise ndi othandizira pakamwa. Zakudya zama carb ochepa ndizo njira yokhayo yoyenera kwa odwala omwe ali ndi kunenepa kwambiri, prediabetes ndi matenda a shuga a 2. Mankhwala, kuphatikizapo mkamwa hypoglycemic mankhwala. Mukamagwiritsa ntchito vildagliptin pa mlingo wa 50-100 mg wa patsiku kwa odwala omwe ali ndi vuto la matenda a shuga 2, ndikudziwika komwe kumachitika pantchito yama cell a pancreatic. Mankhwala Glucophage Long ndiwocheperako kuposa mankhwala ena onse a metformin kuyambitsa kutsegula m'mimba komanso zina.

Kumwa mankhwalawa sikutanthauza kukhala ndi moyo wopanda nkhawa. Mankhwalawa okwera mtengo, mogwirizana ndi malangizo, sanalembedwe chithandizo cha matenda 2 a shuga mwa ana ndi amayi apakati, chifukwa cha kusowa kwa chidziwitso chokhudzana ndi gawo lomwe limagwira mthupi la thupi m'magulu awa. Kafukufuku wazachipatala wautali wotalika mpaka zaka 2 sanawonetse kupatuka kowonjezereka mu mbiri yachitetezo kapena zoopsa zomwe sizinachitike pogwiritsira ntchito vildagliptin monga monotherapy. Zosungidwa ndi nthawi Mankhwalawa amayenera kusungidwa m'malo owuma osagwiritsidwa ntchito ndi ana pamtunda osapitirira 30 ° C.

Mapiritsi a Glucofage Amatenga pang'onopang'ono, koma amakhala nthawi yayitali kuposa mankhwala a Glucofage. Amathandizira bwino kuposa Siofor komanso mitengo yotsika mtengo yopanga Russian. Mtengo wa Galvus, komwe mungagule Mtengo wa Galvus 50 mg, zidutswa 28, m'masitolo ogulitsa mankhwala ku Moscow amasiyana pakati pa ma ruble 720-800. Popeza odwala opitirira zaka 65 nthawi zambiri amakhala ndi kuchepa kwa aimpso, Galvus Met imayikidwa m'gulu lino la odwala omwe ali ndi mlingo wochepa womwe umatsimikizira kuti matenda a glucose amakhala nawo pokhapokha atatha kudziwa QC kuti itsimikizire ntchito yachilendo. Musatenge Glucophage nthawi yoyamwitsa, chifukwa chinthu chogwira chimalowa mkaka.

Ma Analogs a Metformin

• Bagomet,
• Glycon
• Glyminfor,
• Glyformin
• Chikwanje,
• Glucophage Long,
• Langerine
• Methadiene
• Metospanin
• Metfogamma 1000,
• Metfogamma 500,
• Metfogamma 850,
• Metformin
• Metformin Richter,
• Metformin Teva,
• Metformin hydrochloride,
• Nova Met
• NovoFormin,
• Siofor 1000,
• Siofor 500,
• Siofor 850,
• Sofamet
• Fomu,
• Forin Pliva.

Zizindikiro za matenda ashuga - kanema

Kuyerekeza kwa Metformin ndi Fomu

Metformin ndi formin si mankhwala omwewo. Kuti mudziwe njira yabwino, ndikofunikira kufananiza mankhwala ndikuwona kusiyana kwawo, kufanana kwawo.

Sizikupanga nzeru kusankha mankhwala omwe ali bwino kutengera mawonekedwe ake. Mankhwala onse awiriwa ali ndi chinthu chimodzi chomwe chikugwiritsidwa ntchito pakuphatikizika ndi zisonyezo zogwiritsidwa ntchito.

Metformin ndi formin amatengedwa Mlingo wofanana.

Mapiritsi sayenera kutafuna. Amadyedwa yonse ndikutsukidwa ndimadzi ambiri. Izi zimachitika bwino mukamadya kapena mukatha kudya. Kuchuluka kwa madyerero patsiku kumatengera kuuma kwa mkhalidwe wa wodwalayo.

Kumayambiriro kwa mankhwalawa, 1000-1500 mg patsiku amalembedwa, ndikugawa kuchuluka kwa 3 waukulu. Pambuyo pa masabata 1-2, mlingo umatha kusintha malingana ndi kuchuluka kwa zinthu zomwe zimafunikira kuti magawo azikhala ndi kuchuluka kwa shuga.

Mutha kusinthira ku Metformin kapena Formmetin kuchokera kuma analogi ena patsiku limodzi lokha, popeza kuchepetsa mlingo sikufunika.

Ngati mulingo wonjezeredwa pang'onopang'ono, ndiye kuti kulekerera kwa mankhwalawo kudzakulirakulira, popeza mwayi wazotsatira zoyambira m'mimba zimachepa. Mlingo wofanana patsiku ndi 2000 mg, koma oposa 3000 mg ndi oletsedwa.

Mutha kusinthira ku Metformin kapena Formmetin kuchokera kuma analogi ena patsiku limodzi lokha, popeza kuchepetsa mlingo sikufunika. Koma onetsetsani kuti mwadya moyenera.

Mankhwala amatha kumwedwa panthawi ya insulin.

Pankhaniyi, mlingo woyamba ukhale 500-850 mg patsiku. Gawani chilichonse katatu. Mlingo wa insulin amasankhidwa pamalangizo a madokotala kutengera zotsatira za kuyezetsa magazi.

Kwa ana, onse mankhwala amaloledwa kuchokera zaka 10. Poyamba, mlingo ndi 500 mg patsiku. Mutha kumwa kamodzi patsiku ndi chakudya madzulo. Pambuyo pa masabata awiri, mlingo umasintha.

Popeza Metformin ndi Formmetin ali ndi zomwe zimapangidwanso, zomwe zimabweretsa ndizofanana. Dzuka:

• mavuto ndi chakudya cham'mimba, chomwe chimaphatikizidwa ndi kupweteka kwam'mimba, kutsegula m'mimba, kusanza, kusanza, kutsekemera kwazitsulo mkamwa, bata,
• kusowa kwa vitamini, makamaka B12 (mogwirizana ndi izi, odwala amathandizanso kukonzekera mavitamini),
• thupi lawo siligwirizana ndi zigawo zikuluzikulu za mankhwalawa (zoonekera pakhungu, pakhungu, kuyabwa, kuwawa),
• kuchepa magazi
• lactic acidosis,
• kutsitsa shuga m'magazi m'munsi mwabwinobwino.

Contraindication a Metformin ndi Formetin ndi awa:

• aakulu ndi pachimake metabolic acidosis,
• glycemic coma kapena mkhalidwe patsogolo pake,
• Kusokonezeka kwa chiwindi,
• kusowa kwamadzi,
• kuphwanya impso ntchito,
• kulephera kwamtima komanso kulowerera m'mitsempha,
• matenda opatsirana
• mavuto kupuma
• uchidakwa.

Kwa ana, onse mankhwala amaloledwa kuchokera zaka 10.

Mankhwalawa onse ndi oletsedwa kugwiritsa ntchito musanachite opareshoni. M'pofunika kudikirira masiku 2 musanachitike opareshoni.

Kodi pali kusiyana kotani?

Kusiyana pakati pa Metformin ndi Formmetin kumangopezeka m'mapiritsi. Zogulitsa zonsezi zimakhala ndi povidone, magnesium stearate, croscarmellose sodium, madzi. Koma Metformin ilinso ndi gelatinized starch ndi microcrystalline cellulose.

Mapiritsiwo ali ndi chipolopolo, chomwe chimakhala ndi talc, sodium fumarate, utoto.

Pogula mankhwala, ndikofunikira kuyang'anira zomwe zili pazinthu zothandizira: akapanda kukhala, aposa. . Zomwe zimakhala zotsika mtengo

Zomwe zimakhala zotsika mtengo

Mwa mankhwala onsewa, opanga ndi makampani monga Canon, Richter, Teva, ndi Ozone.

Mlingo wa mankhwala ophatikizira piritsi limodzi ndi 500, 850 ndi 1000 mg uliwonse. Pamtengo, onse a Metformin ndi Formmetin ali mgulu lofanana: woyamba ungagulidwe ku Russia pamtengo wa pafupifupi ruble 105 kwa phukusi la mapiritsi 60, ndipo kwa chachiwiri, mtengo wake uzikhala pafupifupi ma ruble 95.

Zolemba Zosintha Zosankha za Fomuine

Choyamba, ndikofunikira kuzindikira kuti Forthine sanapangidwe poyambirira kuti athetse thupi lolemera. Koma amachepetsa kwambiri njira yobwera ndi chakudya chamafuta. Nthawi zambiri mankhwalawa amagwira ntchito pama carbohydrate othamanga. Zotsatira zake, kuchuluka kwa shuga kumachepa, ndipo zochitika za pancreatic zimabwereranso. Koma chifukwa chiyani zonsezi zimagwirizanitsidwa ndi kuchepa thupi? M'malo mwake, kulumikizana ndikulunjika.

Mothandizidwa ndi Formetin, mutha kupanga zinthu zomwe zimapangitsa kuti kuchepetsa thupi kuzikhala kosavuta komanso kosavuta. Ngakhale muyenera kutsatira zina zowonjezera. Kuti muchepetse kunenepa mukamamwa mapiritsi otere, muyenera kuganizira izi:

• Siyani kugwiritsa ntchito zakudya zokhala ndi shuga,
• chakudya chilichonse ayenera kuchepetsedwa
• Kuti muchepetse kuchepa thupi, muyenera kudzipatsa zolimbitsa thupi.
• Pambuyo masiku 20 motsatana, ayenera kupuma kwa mwezi umodzi.

Chifukwa chake, Forethine alibe chozizwitsa china chilichonse. Ndipo lonjezo loti "athetsa mafuta" ndiwongochenjera chabe. Koma, komabe, ndizotheka kukwaniritsa kuchepetsa thupi pogwiritsa ntchito. Ndipo ndemanga zomwe zimaperekedwa pa Formetin kuti muchepetse thupi zimangotsimikizira izi. Zikuwonekerabe kuti tanthauzo la kugwiritsa ntchito mapiritsiwo ndi liti kwenikweni. Kenako zotsatira zakuvomera kwawo ndizabwino kwambiri.

Limagwirira ntchito ya Metformin

Glucophage - amatchedwanso metformin hydrochloride, piritsi lomwe limapangidwa kuti likhale ndi akulu akulu odwala matenda ashuga a mtundu 2. Mankhwala amatha kuthetsa shuga mu chiwindi ndikuchepetsa kuyamwa kwa glucose m'matumbo. Komabe, ngati mulibe insulin m'magazi a anthu, metformin sapereka zotsatira.

Kuchokera pazomwe tafotokozazi, funso limabuka: chifukwa chiyani anthu amasankha mapiritsi awa kuti achepetse thupi? Ndipo chinthu apa ndikuti mankhwalawa amalepheretsa kupangika kwamafuta mthupi lathu. Komanso, mafuta amasinthidwa kukhala mphamvu. Ndi chifukwa chake othamanga ambiri amagwiritsa ntchito glucophage kuti achepetse thupi.

Magwiridwe a mapiritsi ndi awa:

• Imachepetsa mayamwidwe am'mimba m'matumbo,
• amalimbikitsa kukhatikiza kwamphamvu kwa mafuta acids,
• Amathandiza kuchepetsa thupi komanso kukhazikika pamtunda,
• bwino minyewa yodwala,
• amachepetsa kupanga insulin
• nkhondo yolimba.

Munthu aliyense amene anaganiza zochepetsa thupi mothandizidwa ndi metformin ayenera kumvetsetsa bwino mfundo imodzi: mankhwalawa si panacea yowonjezera kulemera. Metformin siziwotcha mafuta, zimangothandiza kuonetsetsa kuti thupi lathu limagwiritsa ntchito ma deposits amafuta, osati minofu ya minofu. Choyambirira cha ichi ndichakudya choyenera.

Kutenga metformin, muyenera kusiya zakudya zamafuta othamanga (shuga, maswiti, nthochi, ndi zina), komanso mpunga woyera, mbatata, pasitala, "zipatso" zothamanga "m'matumba. Pazakudya za tsiku ndi tsiku, ngati simudzipatsa nokha masewera olimbitsa thupi, pazikhala zosaposa 1199 kcal.

Iwo ali osavomerezeka kuti apereke mankhwala kwa odwala:

• ndi vuto la impso ndi chiwindi,
• ndi matenda ashuga a ketoacidosis,
• ngati akudwala matenda ashuga komanso okoma.
• ndi matenda opatsirana nthawi yayitali kapena pachimake, omwe angayambitse kusokonekera kwa impso (hypoxia, kuchepa madzi m'thupi, sepsis, malungo, matenda a impso, kugwedezeka) kapena kutsogolera kwa minofu hypoxia (myocardial infarction, kupuma, komanso kulephera kwa mtima),
• Mankhwala a insulin chifukwa cha opareshoni kapena kuvulala kwambiri,
• ndi uchidakwa woperewera kapena pambuyo poyamwa poizoni,
• ndi chidwi chachikulu,
• pa mimba ndi kuyamwa,
• ndi acidosis,
• ndi chakudya chama hypocaloric.

Kuphatikiza apo, simuyenera kugwiritsa ntchito mawonekedwe a Formetin 2 m'mbuyomu komanso pambuyo pa maphunziro a x-ray ndi radioisotope, pomwe ma reagents okhala ndi ayodini amagwiritsidwa ntchito ngati njira yosiyanitsa.

Sitikulimbikitsidwanso kugwiritsa ntchito mankhwalawa pochiza odwala omwe ali ndi zaka zopitilira 60 omwe amagwira ntchito yayikulu, kuti apewe kukula kwa lactic acidosis mwa iwo.

Zotsatira Zogwiritsa Ntchito Mankhwala

Formmetin ndi mankhwala apadziko lonse: angagwiritsidwe ntchito monotherapy kapena kuphatikizidwa ndi mankhwala ena a hypoglycemic, kuphatikiza jakisoni wa insulin.

Koma nthawi zina, pochiza matenda othandizira, kuchira kwovuta kumatha kukhala ndi zotsatirapo zoyipa.

1. Ndi makonzedwe omwewo a Danazol, pali chiopsezo cha zotsatira za hypoglycemic, kotero mlingo wa mankhwalawo uyenera kuyang'aniridwa mosamalitsa kapena kusinthanitsa ndi analog.
2. Akaphatikizidwa ndi cimetidine, mawonekedwe a metformin amalephereka, kuchuluka kwake mthupi kumatha kupereka mphamvu yosagwirizana ndi hypoglycemic.
3. Kutha kwa coumarin kumachokera ku ziletsa metformin.
4. Mankhwala osakanikirana ndi carbazole, NSAIDs, clofibrate, insulin, ACE inhibitors, cytophosphamide, β-blockers, sulfonylureas, oxytetracycline amathandizira ntchito ya metformin.
5. Kuphatikiza komweko kwa glucagon, epinephrine, thiazide diuretics, mahomoni a chithokomiro amalepheretsa kugwira ntchito kwa formin.

Pogwiritsa ntchito njira zakulera zamkamwa, mayi ayenera kuuza mitundu ya mankhwalawo kwa endocrinologist kuti asinthe mlingo wa Formetin. Osam'patsa mankhwala komanso kuphatikiza ndi Nifedipine, womwe umakulitsa kuchuluka kwa metformin m'magazi, imathandizira kuyamwa kwake, imachepetsa kuchoka. Ngati pali vuto ndi impso, zotsatira zake zingayambitse kukomoka.

Ngati mankhwalawa adakhazikitsidwa ndi ethanol, kuphatikiza ndi metformin, chiopsezo cha lactic acidosis chimawonjezeka kwambiri.

Formethine si vuto lotchedwa panacea, ngati mankhwala aliwonse osokoneza bongo, koma ngati zonse zofunika zikutsatiridwa, zimathandiza kuwongolera matenda ashuga kwa nthawi yayitali, osalimbikitsa thupi, monga mawonekedwe ake.

Kodi mankhwalawa ndi chiyani: mikhalidwe yayikulu

Glucophage ndi mankhwala omwe amakupatsani mwayi wokhala ndi thanzi labwino kwa odwala matenda ashuga. Muli zinthu zomwe zimachepetsa insulin ndi shuga m'magazi am'magazi, zomwe zimapangitsa kuti mafuta awonongeke.

Chifukwa cha chikhalidwe ichi, mankhwalawo agwiritsidwa ntchito polimbana ndi kunenepa kwambiri. Mosiyana ndi mankhwala ena omwe amatha kuwotcha mafuta, Glucofage ilibe zotsatira zoyipa. Kuwonetsera kosafunikira kumatha kuchitika kokha chifukwa chogwiritsa ntchito molakwika mankhwalawo.

Cholinga chachikulu cha Glucofage ndikuchotsa glucose ndi cholesterol yoyipa m'magazi, zomwe nthawi zambiri zimaposa zomwe zili zovomerezeka kwa odwala onenepa. Mankhwala amakulolani kubwezeretsa kagayidwe ndikupangitsa kuti mayendedwe azinthu zothandiza omwe azikhala ndi phindu pathupi lathunthu.

Glucophage: limagwirira ntchito

Mankhwala a hypoglycemic, chifukwa cha zomwe zimapangidwira, amachepetsa kuwonetsa kwa hyperglycemia osathandizira kuti pakhale hypoglycemia.

Glucophage ilinso ndi zotsatirazi:

• Kubwezeretsa kagayidwe ka lipid pochepetsa triglycerides, LDL ndi cholesterol,
• Zimawonjezera kuyankha kwa ma peripheral receptors ku mankhwala ambiri (insulin),
• Imathandizira kugwira minofu ya minofu kuti ikhale ndi shuga mosavuta,
• Imachepetsa njira yothandizira kukhathamiritsa chakudya m'mimba ndi m'magazi a gluconeogene omwe amapezeka m'chiwindi.

Chuma china cha mankhwalawa ndi kuchepa kwa chilakolako cha chakudya. Koma, mukamamwa mankhwalawa, kulawa kwazitsulo pamlomo wamkamwa kumatha kuoneka, nseru.

Malangizo a Glucophage

Pa mphamvu yayikulu ya metformin, imayenera kuledzera mwadongosolo, malinga ndi chiwembu china. Kutalika kwa mankhwalawa kunenepa kwambiri sikungathe kupitirira masiku 22, ngakhale zotsatira zake sizikugwirizana ndi wodwalayo, muyenera kupuma - miyezi iwiri ndipo kungobwereza mankhwalawo.

Ndikulimbikitsidwa kuti mutenge Glucophage musanadye chilichonse, chotsukidwa ndi madzi oyera. Mlingo wa mankhwalawa ndi 500 mg, koma ngati nseru imakhudzidwa pafupipafupi, kuchuluka kwake kuyenera kuchepetsedwa ndi 1/3. Pa chithandizo, muyenera kusiya mowa, shuga ndi chakudya chamagulu.

Kutheka contraindication ndi zosafunika zotsatira

Ngati mutsatira malangizo munthawi ya chithandizo, glucophage kwenikweni sikuyambitsa mavuto. Koma pali zotsutsana pa kugwiritsa ntchito mankhwalawa:

• Mtundu woyamba wa shuga
• Chiyembekezo cha mwana,
• Nthawi zowawa ndi zothandizanso,
• Matenda a mitsempha, mtima,
• Matenda a impso
• Khalidwe lomwa mowa kwambiri.

Kuwonetsera kosafunikira komwe nthawi zina kumachitika pakumwa kumakhala kofanana ndi kuledzera. Zizindikiro zoyipa ndi izi:

• Migraine imagunda
• Kumva nseru, kusanza,
• Mbadwo wamafuta
• Tulutsani chopondapo
• Thupi
• Lactociadosis
• Colic m'matumbo, kufooka kwambiri.

Zoyipa zoyambirira zimawoneka kumayambiriro kwa mankhwalawa ndipo zimagwirizanitsidwa ndi kugwiritsa ntchito mosayenera mankhwalawa komanso zakudya zopanda thanzi. Pazizindikiro zoyambirira za zovuta, tikulimbikitsidwa kuchepetsa mlingo. Ngati palibe kusintha, pitani kuchipatala.

Mapiritsi a Glucophage amaphatikizidwa muyeso ya mapiritsi azakudya zabwino

Malangizo a Glucophage ogwiritsira ntchito

Piritsi limodzi lili:

Zogwira pophika: metformin hydrochloride - 500/850/1000 mg,

Zosakaniza zothandizira: povidone 20/34/40 mg, magnesium yothira 5.0 / 8.5 / 10.0 mg. Filamu wachimvekere:

Mlingo 500 mg ndi 850 mg: hypromellose 4.0 / 6.8 mg.

Mlingo wa 1000 mg: pure opadrai 21 mg (hypromellose 90.90%, macrogol 400 4.550%, macrogol 8000 4.550%).

Mlingo 500 mg, 850 mg:
Mapiritsi oyera, ozungulira, a biconvex.
Gawo la mtanda likuwonetsa yunifolomu yoyera.
Mlingo wa 1000 mg:
Masamba oyera, ozungulira, mapiritsi a biconvex, ophatikizidwa ndi filimu, ali pachiwopsezo mbali zonse ziwiri ndipo adalemba "1000" mbali imodzi.
Gawo la mtanda likuwonetsa yunifolomu yoyera.

Zotsatira za pharmacological

Glucofage ® imachepetsa hyperglycemia, osatsogolera pakupanga hypoglycemia. Mosiyana ndi zomwe zimachokera ku sulfonylurea, sizimalimbikitsa kutulutsa insulin ndipo sizimatero

Hypoglycemic zotsatira mu wathanzi anthu. Zimawonjezera chidwi cha zotumphukira zolandilira ku insulin ndikugwiritsa ntchito shuga ndi maselo. Imachepetsa kupanga shuga kwa chiwindi poletsa gluconeogeneis ndi glycogenolysis. Kuchepetsa mayamwidwe m'matumbo.

Metformin imathandizira kapangidwe ka glycogen pochita glycogen synthase. Kuchulukitsa kuthekera kwamitundu yonse yamtundu wama glucose oyenda.

Kuphatikiza apo, imakhala ndi phindu pa metabolidi ya lipid: imachepetsa zomwe zimakhala ndi cholesterol yonse, lipoproteins yotsika komanso triglycerides.

Ngakhale mutatenga Metformin, thupi la wodwalayo limakhalabe lolimba kapena limatsika pang'ono.

Pharmacokinetics

Pambuyo pakukonzekera pakamwa, metformin imatengedwa kuchokera kumimba kwathunthu. Mtheradi bioavailability ndi 50-60%. Kuzungulira kwakukulu (Stax) (pafupifupi 2 μg / ml kapena 15 μmol) mu plasma kumachitika pambuyo pa maola a 2,5.

Ndi kuyamwa kwa munthawi yomweyo, kuyamwa kwa metformin kumachepetsedwa ndikuchedwa. Metformin imagawidwa mwachangu mu minofu, sikuti imagwira mapuloteni a plasma.

Amapangidwira pamlingo wofooka kwambiri ndikuwonetsa impso. Kuwonekera kwa metformin m'maphunziro abwino ndi 400 ml / mphindi (kuchulukitsa kanayi kuposa kutulutsa chilolezo cha creatinine), zomwe zikuwonetsa kukhalapo kwa kubisala kwa canalic secretion.

Hafu ya moyo ndi pafupifupi maola 6.5. Ndi kulephera kwa aimpso, zimachulukana, pamakhala chiopsezo cha kukopeka kwa mankhwalawa.

Zizindikiro zogwiritsidwa ntchito

Type 2 shuga mellitus, makamaka kwa odwala omwe ali ndi kunenepa kwambiri, komanso kulephera kwamankhwala othandizira kudya komanso zochitika zolimbitsa thupi:
• Akuluakulu, monga monotherapy kapena kuphatikiza ena othandizira pakamwa, kapena ndi insulin,
• mwa ana kuyambira zaka 10 monga monotherapy kapena kuphatikiza insulin.

Mimba komanso kuyamwa

Matenda a shuga omwe sanakulipiridwe panthawi ya kubereka amalumikizidwa ndi chiwopsezo chowonjezeka cha zilema zakubadwa ndi kufa kwa perinatal. Zambiri zomwe zikusonyeza kuti kutenga metformin mwa amayi apakati sikuti kumawonjezera mwayi wokhala ndi vuto la kubala mwa ana.

Pokonzekera kutenga pakati, komanso pathupi panu mukumwa Metformin, mankhwalawa ayenera kutha, ndipo mankhwala a insulin ayenera kuikidwa. Ndikofunikira kusungitsa glucose omwe ali m'madzi am'magazi pamlingo woyandikira kwambiri kuti achepetse kusokonezeka kwa fetal.

Metformin amachotseredwa mkaka wa m'mawere. Zotsatira zoyipa za akhanda pa nthawi yoyamwitsa pamene mukumwa metformin sizinawoneke. Komabe, chifukwa cha kuchuluka kwa deta, kugwiritsidwa ntchito kwa mankhwalawa panthawi yoyamwa sikulimbikitsidwa. Lingaliro loletsa kuyamwitsa liyenera kuchitika poganizira zabwino za kuyamwitsa ndi chiopsezo chomwe chingakhalepo

mavuto mu mwana.

Mlingo ndi makonzedwe

Monotherapy ndi kuphatikiza mankhwalawa kuphatikiza ena othandizira pakamwa hypoglycemic:

• Mlingo woyambira wamba ndi 500 mg kapena 850 mg katatu patsiku mutatha kudya kapena pakudya. Kuwonjezereka kwapang'onopang'ono kwa mlingo kumatha kutengera kuchuluka kwa shuga m'magazi.

• Mankhwala okonza mankhwalawa nthawi zambiri amakhala 1500-2000 mg / tsiku. Kuti muchepetse mavuto kuchokera m'matumbo am'mimba, mlingo wa tsiku ndi tsiku uyenera kugawidwa mu Mlingo wa 2-3. Mlingo wapamwamba ndi 3000 mg / tsiku, logawidwa pazidutswa zitatu.

• Kuchepetsa kwa pang'onopang'ono kumathandizanso kulolerana kwam'mimba.

• Odwala omwe amamwa metformin mu Mlingo wa 2000-3000 mg / tsiku amatha kusinthidwa ndi mankhwala a Glyukofazh 1000 mg. Mlingo woyenera kwambiri ndi 3000 mg / tsiku, womwe umagawidwa pazigawo zitatu.

Pankhani yakukonzekera kusinthaku kuti mutenge wothandizanso wina wa hypoglycemic: muyenera kusiya kumwa mankhwalawa ndikuyamba kumwa Glucofage® pamwambapa womwe wafotokozedwatu.

Kuphatikiza ndi insulin:

Kukwaniritsa bwino shuga wamagazi, metformin ndi insulin zitha kugwiritsidwa ntchito ngati mankhwala ophatikiza. Mlingo woyamba wa Glucofage® ndi 500 mg kapena 850 mg kawiri pa tsiku, pomwe mlingo wa insulin umasankhidwa potengera kuchuluka kwa shuga m'magazi.

Ndege ndi achichepere: mwa ana kuyambira wazaka 10, Glucofage ® ikhoza kugwiritsidwa ntchito limodzi mu monotherapy komanso kuphatikizidwa ndi insulin. Mulingo woyambira woyamba ndi 500 mg kapena 850 mg 1 nthawi patsiku mutatha kudya kapena. Pambuyo masiku 10-15, mlingo uyenera kusinthidwa potengera kuchuluka kwa magazi. Mulingo wambiri watsiku ndi tsiku ndi 2000 mg, wogawidwa pamitundu iwiri.

Amuna okalamba: chifukwa cha kuchepa kwa ntchito yaimpso, mlingo wa metformin uyenera kusankhidwa poyang'anira zochitika za aimpso (kudziwa kuchuluka kwa creatinine mu seramu osachepera 2-4 pachaka). Kutalika kwa mankhwala

Glucofage ® iyenera kumwedwa tsiku lililonse, osasokoneza. Ngati chithandizo chalekeka, wodwalayo ayenera kudziwitsa dokotala.

Zotsatira zoyipa

Pafupipafupi mavuto a mankhwala amawerengeredwa motere:

Nthawi zambiri:> 1/10 Mafupipafupi:> 1/100, 1/1000, 1/10 000, P ', K "J

Chlorpromazine: akagwiritsidwa ntchito mu milingo yayikulu (100 mg patsiku) amawonjezera kuchuluka kwa shuga m'magazi, kuchepetsa kutulutsidwa kwa insulin. Mankhwalawa antipsychotic ndipo atayimitsa chomaliza, kusintha kwa mankhwalawa kumafunikira motsogozedwa ndimagazi a shuga.

Glucocorticosteroids (GCS) yachilengedwe komanso yachilengedwe imachepetsa kulolera kwa shuga, kuwonjezera kuchuluka kwa shuga m'magazi, nthawi zina kumapangitsa ketosis. Mankhwalawa corticosteroids ndipo atayimitsa yotsirizira, kusintha kwa mankhwala Glucofage® kumafunika motsogozedwa ndi kuchuluka kwa shuga m'magazi.

Diuretics: kugwiritsa ntchito munthawi yomweyo "kudzikongoletsa" okodzetsa kungayambitse kukula kwa lactic acidosis chifukwa chakulephera kugwira ntchito kwaimpso. Glucofage ® sayenera kukhazikitsidwa ngati chilolezo cha creatinine chiri pansi pa 60 ml / min.

Agon2 a adrenergic omwe ali ndi vuto: amalimbikitsa kuchuluka kwa shuga m'magazi chifukwa cha kukoka kwa ma betag-adrenergic receptors. Poterepa, ndikofunikira kuwongolera kuchuluka kwa shuga m'magazi. Ngati ndi kotheka, insulin ikulimbikitsidwa.

Pogwiritsa ntchito nthawi yomweyo mankhwala omwe ali pamwambawa, kuwunika pafupipafupi magazi a shuga kungafunike, makamaka kumayambiriro kwa chithandizo. Ngati ndi kotheka, mlingo wa metformin ungasinthidwe munthawi yamankhwala ndikatha.

Angiotensin-converting enzyme inhibitors ndi mankhwala ena a antihypertgency amatha kutsitsa magazi. Ngati ndi kotheka, mlingo wa metformin uyenera kusinthidwa.

Ndi munthawi yomweyo kugwiritsa ntchito mankhwala Glucofage® ndi sulfonylurea zotumphukira, insulin, acarbose, salicylates, kukula kwa hypoglycemia ndikotheka.

Nifedipine imawonjezera mayamwidwe ndi C_mosamala metformin.

Mankhwala a Cationic (amiloride, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamteren, trimethoprim ndi vancomycin) omwe amapezeka mu aimpso tubules amapikisana ndi metformin pa mathirakiti

machitidwe ndipo amatha kutsogolera kuwonjezeka kwa C yake, malangizo apadera

Lactic acidosis ndichosowa koma chachikulu (kufa kwakukulu pakalibe chithandizo chamankhwala mwadzidzidzi) chomwe chitha kuchitika chifukwa cha kuchuluka kwa metformin. Milandu ya lactic acidosis mutatenga metformin imapezeka makamaka mwa odwala omwe ali ndi matenda osokoneza bongo omwe amalephera kwambiri aimpso.

Zina zokhudzana ndi ngozi, monga zotulutsidwa, ziyenera kulingaliridwa.
shuga mellitus, ketosis, kusala kudya kwa nthawi yayitali, uchidakwa, kulephera kwa chiwindi, komanso vuto lililonse lomwe lingakhale ndi hypoxia yayikulu. Izi zitha kuthandiza kuchepetsa zochitika za lactic acidosis.

Muyenera kuganizira za chiopsezo cha lactic acidosis ndi mawonekedwe a zosakhazikika, monga kukokana kwa minofu, limodzi ndi vuto la dyspeptic, kupweteka kwam'mimba komanso asthenia yayikulu. Lactic acidosis imadziwika ndi kufupika kwa acidotic, kupweteka kwam'mimba komanso hypothermia yotsatiridwa ndi chikomokere. Diagnostic labotale magawo ndi kuchepa kwa magazi pH (osachepera 7.25), lactate zili mu plasma yoposa 5 mmol / l, kuchuluka kwa anion ndi mulingo wa lactate / pyruvate. Ngati metabolic acidosis ikukayikira, ndikofunikira kusiya kumwa mankhwalawo ndikuwonana ndi dokotala nthawi yomweyo.

Kugwiritsa ntchito metformin kuyenera kusiyidwa kwa maola 48 kusanachitike opaleshoni yomwe ikukonzedwa ndipo kutha kupitiliridwanso osapitilira maola 48 zitatha, pokhapokha pakuwunikira ntchito ya impso idadziwika kuti ndiyabwino.

Popeza metformin imachotsedwa impso, isanayambe chithandizo komanso pafupipafupi, kuvomerezedwa kwa creatinine kuyenera kutsimikiziridwa: kamodzi pachaka kwa odwala omwe ali ndi vuto laimpso, komanso kawiri pachaka kwa odwala okalamba, komanso kwa odwala omwe ali ndi chilolezo cha creatinine ku malire ochepera.

Kusamalidwa makamaka kuyenera kuchitika ngati vuto laimpso lingatheke mwa okalamba, ndikugwiritsa ntchito mankhwala a antihypertensive, okodzetsa kapena mankhwala osapweteka a antiidal.

Ana ndi achinyamata

Kuzindikiritsidwa kwa matenda a shuga a 2 kuyenera kutsimikiziridwa musanayambe chithandizo ndi metformin.

Kuwongolera mosamala kwambiri ndikofunikira kwa ana

Chenjezo lina:

• Odwala amalangizidwa kuti azipitiliza kudya.

M'maphunziro azachipatala omwe amakhala chaka chimodzi, adawonetsedwa kuti metformin sikukhudza kukula ndi kutha msinkhu. Komabe, poganizira za kuchepa kwa deta yayitali, kuwunikira mosamala za zotsatira za metformin pamadongosolo awa mwa ana akulimbikitsidwa, makamaka kwa ana, akadzakula.

chakudya tsiku lonse.Odwala onenepa kwambiri amalangizidwa kuti azitsatira zakudya zama calorie otsika (koma osachepera 1000 kcal / tsiku) • Ndikulimbikitsidwa kuti mayeso a labotale azizolowereka azichita pafupipafupi kuyang'anira matenda ashuga.

• Metformin siyimayambitsa hypoglycemia pa nthawi ya monotherapy, koma kusamala kumalangizidwa ukamagwiritsidwa ntchito limodzi ndi insulin kapena othandizira ena a hypoglycemic (mwachitsanzo, sulfonylureas, repaglinide, etc.).

Zokhudza mphamvu pakutha kuyendetsa magalimoto ndimakina

Monotherapy yokhala ndi Glucofage® siyimayambitsa hypoglycemia, chifukwa chake, sizikhudza kuthekera koyendetsa magalimoto ndi machitidwe.

Komabe, odwala ayenera kuchenjezedwa za chiopsezo cha hypoglycemia mukamagwiritsa ntchito metformin limodzi ndi mankhwala ena a hypoglycemic (zotumphukira za sulfonylurea, insulin, repaglinide, etc.).