Momwe mungagwiritsire ntchito Levemir Flekspen?

Gynecology Qing 1 - zambiri mwatsatanetsatane zolemba za European Cancer Center.

Mafomu ndi kapangidwe kake

Wopangayo amapereka mankhwala a Levemir FlexPen mwanjira yothetsera vuto lomwe limapangidwa kuti likhale lolowerera. Pakukhazikitsa madzi azithandizo mu paketi yokhala ndi mankhwala pali cholembera chapadera chomwe chimakhala chosavuta kugwiritsa ntchito ndipo chimakupatsani mwayi wopereka yankho lenileni. Mankhwalawa ali ndi chithandizo chachitali kwambiri, chomwe chimapereka ndi gawo lalikulu - insulin. Izi ndi sungunuka basal analog a insulin yamunthu. Kutalika kwa mankhwalawa kumafika mpaka maola 24, kutengera mlingo womwe umaperekedwa, ndipo chifukwa cha izi, zitheka kumangokhala wokhazikika kwa 1 kapena 2-piritsi la mankhwala patsiku. Palibe nsonga yotchulidwa mu insulin. Mbali yodziwika bwino ya chinthuchi ndikudziwikiratu kwodziwonetsa nthawi komanso kuthandizira.

Shuga amachepetsedwa nthawi yomweyo! Matenda a shuga m'kupita kwa nthawi angayambitse matenda ambiri, monga mavuto amawonedwe, khungu ndi tsitsi, zilonda zam'mimba, zilonda zam'mimba komanso matenda otupa! Anthu amaphunzitsa zinzake zowawa kuti azisintha shuga. werengani.

Ndikofunika kuti mupeze jekeseni Levemir FlexPen pa matenda a shuga omwe amadalira insulin. Insulin yowonjezereka imalangidwanso kwa odwala omwe apezeka ndi matenda osokoneza bongo omwe amadalira shuga kapena mtundu II shuga. Nthawi zina, kufunika kogwiritsa ntchito Levemir kumatsimikiziridwa kokha ndi dokotala woyenera, kutengera zotsatira zakuwunika kozindikira komanso zomwe wodwalayo ali nazo.

Malangizo ogwiritsira ntchito Levemir Flekspen

Mankhwala omwe atulutsidwa kale a Levemir Flexpen ayenera kugwiritsidwa ntchito mosamalitsa monga adokotala amafunsa.

Mlingo wa mankhwalawa zimatengera kuchuluka kwa insulini yomwe amatulutsidwa ndi kapamba patsiku. Kuchulukitsa chiwerengerochi kumatsutsana. Mlingo uyenera kuwerengeredwa ndi dokotala wazambiri, koma mutha kudziyang'anitsanso nokha insulin. Izi zikufunika kuyesa koyambira.

Njira yothetsera vutoli imalowetsa ntchafu kapena phewa. Komabe, insulini imagwira ntchito mwachangu ngati jakisoni wachita khoma la m'mimba. Chiwerengero cha jakisoni patsiku chimasankhidwa payekha kwa wodwala aliyense. Nthawi zambiri, jakisoni woyamba ndi wokwanira, koma ngati ndi kotheka, mankhwalawa "Levemir Flexpen" amaperekedwa kawiri pa tsiku.

Bongo

The insulin Levemir Flexpen imafuna kutsatira mosamalitsa Mlingo womwe adalimbikitsidwa ndi adokotala komanso malangizo, kuwonjezereka kwawo kowopsa kumakhala kowopsa ndikakulitsa kwa bongo, komwe kumadziwika ndi kuchepa kwa shuga m'magazi a anthu. Pofuna kuthana ndi hypoglycemia, muyenera kudya chidutswa cha shuga kapena chilichonse chomwe chili ndi zopatsa thanzi. Ichi ndichifukwa chake odwala matenda ashuga nthawi zonse azikhala ndi maswiti nthawi zonse. Ngati vuto la wodwalayo silikuyenda bwino, amapatsidwa 0,5-1 mg wa glucagon kapena shuga. Vutolo likadzakhala labwinobwino, wodwalayo ayenera kupewa kupezanso matenda a hypoglycemia pakudya zakudya zotsekemera.

Zoletsa pakugwiritsa ntchito ndi zizindikiro zammbali

Malinga ndi malangizo, mankhwala omwe akupangidwawo sangagwiritsidwe ntchito ndi odwala omwe ali ndi vuto lililonse pazamankhwala ake. Kuphatikiza apo, Levemir Flexpen sakulimbikitsidwa kwa anthu ochepera zaka 6, chifukwa palibe kafukufuku wazachipatala yemwe adachitidwa m'gululi la odwala. Ngati mugwiritsa ntchito mankhwalawa moyenera, mudzatha kupewa kutulutsa zotsatira zoyipa. Kupanda kutero, wodwalayo amakumana ndi izi:

• kutsika kwa khungu,
• shuga wa plasma watsika
• kutopa kwambiri, kufooka,
• chisokonezo,
• mantha opanda nzeru,
• kunjenjemera
• kugona
• kuwonongeka kwamawonekedwe
• kukomoka mtima,
• ululu mu akachisi ndi gawo lamatsenga,
• kukokana
• redness, kutupa ndi kuyaka pamalowo jakisoni,
• kutentha thupi
• hyperhidrosis
• kuphwanya kwam'mimba,
• kupuma movutikira
• kutsitsa magazi.

Tulutsani mawonekedwe a Levemir flekspen, ma CD ndikuphatikizira ndi mankhwala.

Njira yothetsera utsogoleri wa sc ndi yowonekera, yopanda utoto.

1 ml
1 cholembera
insulin kunyansidwa
100 PISITES *
300 PIECES *

Omwe amathandizira: mannitol, phenol, metacresol, nthaka acetate, sodium chloride, disodium phosphate dihydrate, sodium hydroxide, hydrochloric acid, madzi d / i.

* 1 unit ili ndi 142 μg ya insulin yopanda mchere, yomwe imagwirizana ndi 1 unit. insulin yamunthu (IU).

3 ml - ma syringe ambiri omwe ali ndi mulingo wambiri (5) - ma CD.

Kufotokozera kwa mankhwalawa kumatengera malangizo ovomerezeka omwe angagwiritsidwe ntchito.

Pharmacological zochita za levemir flekspen

Hypoglycemic mankhwala. Ndi tsamba losungunuka la insulin yaumunthu yokhala ndi lathyathyathya komanso yolosera zochitika zokhala ndi mphamvu yayitali. Yopangidwa ndi recompinant DNA biotechnology pogwiritsa ntchito Saccharomyces cerevisiae.

Mawonekedwe a mankhwala Levemir Flexpen amasiyana kwambiri poyerekeza ndi isofan-insulin ndi insulin glargine.

Kuchitika kwakanthawi kwa mankhwalawa Levemir Flexpen ndi chifukwa chodziyimira pawokha wa maselo a insulir kumalo opangira jakisoni ndikumangidwa kwa mamolekyulu a mankhwalawa kuti a albumin pogwiritsa ntchito cholumikizira ndi chingwe cham'mbali. Poyerekeza ndi isofan-insulin, insulini ya detemir imaperekedwa kwa zotumphukira za minofu pang'onopang'ono. Njira zophatikizidwazo zomwe zimaperekedwako zimapereka chidziwitso chambiri chogwiritsira ntchito mankhwala a Levemir Flexpen poyerekeza ndi isofan-insulin.

Imalumikizana ndi cholandirira chapadera pa cell ya cytoplasmic maselo ndikupanga insulini-receptor zovuta zomwe zimapangitsanso njira zina, kuphatikizapo kaphatikizidwe angapo ofunikira a michere (hexokinase, pyruvate kinase, glycogen synthetase).

Kutsika kwa shuga m'magazi kumachitika chifukwa cha kuchuluka kwa kayendedwe ka intracellular, kuchuluka kwa zotupa, kukondoweza kwa lipogenesis, glycogenogeneis, ndi kuchepa kwa kuchuluka kwa shuga ndi chiwindi.

Mlingo wa 0.2-0.4 U / kg 50%, kuchuluka kwake kwa mankhwalawa kumachitika mosiyanasiyana kuyambira maola 3-4 mpaka maola 14 atatha kutsata. Kutalika kwa nthawi mpaka maola 24, kutengera mlingo, womwe umapereka mwayi wokhala wosakwatira komanso wowerengeka tsiku lililonse.

Pambuyo sc makonzedwe, pharmacodynamic poyankha anali wofanana mlingo kutumikiridwa (pazipita, nthawi ya zochita, ambiri zotsatira).

M'maphunziro a nthawi yayitali (> miyezi isanu ndi umodzi), kuthamanga kwa shuga m'magazi a odwala a 1 mtundu wa mellitus kunali kwabwino kuyerekeza ndi isofan-insulin yokhazikitsidwa pamankhwala oyambira / bolus. Glycemic control (glycated hemoglobin - HbA1C) munthawi ya mankhwala a Levemir Flexpen anali wofanana ndi isofan-insulin, wokhala ndi chiopsezo chocheperako cha hypoglycemia wamasiku osawonjezeka komanso kuchepa kwa thupi ndi Levemir Flexpen.

Mbiri yakuwongolera glucose usiku ndi yosalala komanso yowonjezereka ndi Levemir Flexpen poyerekeza ndi isofan-insulin, yomwe imawonetsedwa pangozi yochepetsetsa usiku wa hypoglycemia.

Pharmacokinetics wa mankhwala.

Pamene s / c makonzedwe a seramu anali ofanana ndi mlingo womwe umaperekedwa.

Cmax imafikiridwa patatha maola 6-8 kuchokera pakukhazikitsa. Ndi regimen yolamulira kawiri tsiku lililonse, Css imatheka pambuyo pa maulamuliro awiri.

Kusinthika kwapakati pa kuphatikizana kumachepa mu mankhwala a Levemir Flexpen poyerekeza ndi kukonzekera kwina kwa insulin.

Madzi ndi makina a i / m amathamanga mwachangu komanso kwakukulu poyerekeza ndi kasamalidwe ka s / c.

Vd wamba wa Levemir FlexPen (pafupifupi 0,1 L / kg) amawonetsa kuti gawo lalikulu la insulin limazungulira m'magazi.

Biotransfform ya mankhwala Levemir Flexpen ndi ofanana ndi kukonzekera kwa insulin yaumunthu, ma metabolites onse omwe amapangidwa satha ntchito.

Terminal T1 / 2 pambuyo pa jekeseni wa sc imatsimikiziridwa ndi kuchuluka kwa kuyamwa kwa subcutaneous minofu ndipo ndi maola 5-7, kutengera mlingo.

Mlingo ndi njira ya mankhwala.

Mlingo wa mankhwalawa umatsimikiziridwa payekhapayekha. Mankhwala Levemir Flexpen ayenera kutumikiridwa 1 kapena 2 nthawi / tsiku malinga ndi zosowa za wodwalayo. Odwala omwe amafunikira kugwiritsa ntchito mankhwalawa 2 kawiri / tsiku kuti azitha kuyendetsa shuga m'magazi amatha kulowa mgonero ngakhale nthawi yamadzulo, kapena asanagone, kapena maola 12 atatha kumwa kwa m'mawa.

Levemir Flexpen amapukusidwa ndi ntchafu mu ntchafu, khoma lamkati lakumbuyo kapena phewa. Ndikofunikira kusintha malo a jekeseni mkati mwa anatomical dera kuti muchepetse kukula kwa lipodystrophy. Insulin imachita zinthu mwachangu ngati itayambitsidwa khoma lakumbuyo lamkati.

Ngati ndi kotheka, mankhwalawa angagwiritsidwe ntchito moyang'aniridwa ndi dokotala.

Odwala okalamba, komanso vuto la chiwindi ndi impso, kuchuluka kwa shuga wamagazi kuyenera kuyang'aniridwa mosamala ndikuwonetsetsa kuti mlingo wa mankhwala uyenera kuchitika.

Kusintha kwa magazi kungafunikenso pakuwonjezera zolimbitsa thupi kwa wodwala, kusintha zakudya zake, kapena mukudwala.

Mukasamutsa insulin wa pakati komanso insulin yayitali kwa Levemir FlexPen insulin, mlingo ndi nthawi zingakhale zofunika. Kuwunikira mosamala kuchuluka kwa shuga m'magulu omasulira ndi masabata oyamba a mankhwala atsopano kumalimbikitsidwa. Malangizo a concomitant hypoglycemic mankhwala angafunike (mlingo ndi nthawi ya makonzedwe osakhalitsa a insulin kukonzekera kapena kumwa mankhwala a mkamwa hypoglycemic).

Malangizo Odwala Ogwiritsira Ntchito cholembera cha FlexPen® Insulin cholembera ndi Dispenser

Cholembera cha syringe cha FlexPen chidapangidwa kuti chigwiritsidwe ntchito ndi njira za jakisoni ya Novo Nordisk insulin ndi singano za NovoFine.

Mlingo wa insulin womwe umayendetsedwa kuchokera pa 1 mpaka 60 mayunitsi. itha kusintha mu 1 unitMa singano a NovoFine S mpaka 8 mm kapena ofupikira kutalika amapangidwira kuti mugwiritse ntchito ndi cholembera cha syringe ya FlexPen. Chizindikiro cha S chili ndi singano zazifupi. Kuti mupeze chitetezo, nthawi zonse tengani chida cha insulin m'malo mwanu ngati FlexPen yatayika kapena yowonongeka.

Ngati mukugwiritsa ntchito Levemir Flexpen ndi insulini ina mu cholembera cha Flexpen, muyenera kugwiritsa ntchito njira ziwiri zopangira jakisoni kupereka insulin, imodzi mwa mtundu uliwonse wa insulin.

Levemir Flexpen ndi wogwiritsa ntchito payekha.

Musanagwiritse ntchito Levemir FlexPen, muyenera kuwunika ma CD kuti muwonetsetse kuti mtundu woyenera wa insulin ndi wosankhidwa.

Wodwalayo ayenera kuyang'ana cartridge nthawi zonse, kuphatikizapo pisitoni ya mphira (malangizo ena ayenera kupezeka mu malangizo ogwiritsa ntchito mankhwalawa chifukwa cha insulin), nembanemba wa mphira uyenera kutetezedwa ndi thonje lomwe limayikidwa mu mowa wamankhwala.

Levemir Flexpen silingagwiritsidwe ntchito ngati katiriji kapena jakisoni wa insulini wagwetsedwa, katoniyo wawonongeka kapena waphwanyidwa, chifukwa pali chiopsezo cha insulin kutayikira, kutalika kwa gawo lowoneka la piston ya rabara ndikokulirapo kuposa kupingasa kwa mzere wa code yoyera, malo osungirako a insulin sanafanane ndi omwe akuwonetsedwa, kapena mankhwalawo anali achisanu, kapena insulin idasiya kukhala yowonekera komanso yopanda utoto.

Kuti mupange jakisoni, muyenera kuyika singano pansi pa khungu ndikudina batani loyambira njira yonse. Pambuyo pa jekeseni, singano imayenera kukhalabe pansi pakhungu kwa masekondi 6 osachepera. Chingwe cha syringe chikuyenera kusungidwa mpaka singano itachotsedwa kwathunthu pakhungu.

Pakapita jakisoni aliyense, singanoyo imayenera kuchotsedwa (chifukwa ngati simuchotsa singano, ndiye chifukwa cha kusinthasintha kwa kutentha, madzimadzi amatha kutuluka m'chogoba ndipo insulin ndende imatha kusiyanasiyana).

Musadzazenso katoniyo ndi insulin.

Zotsatira zoyipa Levemir flekspen:

Zotsatira zoyipa zomwe zimawoneka mwa odwala omwe amagwiritsidwa ntchito ndi Levemir Flexpen zimadalira kwambiri mlingo ndipo zimayamba chifukwa cha kupangika kwa mankhwala a insulin. Zotsatira zoyipa kwambiri ndi hypoglycemia, yomwe imayamba kumwa kwambiri ngati mankhwala aperekedwa molingana ndi kufunika kwa insulini. Kuchokera kuzipatala zamankhwala zimadziwika kuti hypoglycemia yayikulu, yomwe imafotokozedwa ngati kufunika kwa kulowererapo, imakhala pafupifupi 6% ya odwala omwe amalandila Levemir Flexpen.

Gawo la odwala omwe amalandila chithandizo ndi Levemir Flexpen, omwe akuyembekezeka kukulitsa zovuta zake, akuti mwina 12%. Zomwe zimachitika chifukwa cha zovuta, zomwe zimayesedwa kuti zimakhudzana ndi Levemir Flexpen panthawi ya mayeso azachipatala, zaperekedwa pansipa.

Zotsatira zoyipa zomwe zimakhudzana ndi kagayidwe kazachilengedwe: nthawi zambiri (> 1%, 0,1%, 0,1%, 0,1%, 0,01%, 0,1%, 2013-03-20

Mitu ya mankhwalawa

Sinthani "Levemir Flekspen" omwe amatha kugwiritsa ntchito mankhwala omwe ali ndi kufanana pakapangidwe ndi kapangidwe ka ntchito. Kusiyana pakati pawo kungakhale mu mawonekedwe a kumasulidwa, kutalika kwa njira yothandizira, komanso mankhwalawa, omwe ali analogue a Levemir, ali ndi malire ake pakutenga ndi mawonekedwe ena a chithandizo:

Kusungidwa koyenera

Kuti Levemir asunge zochiritsika zake momwe zingathere, ziyenera kumupatsa njira yabwino yopulumutsira. Pachifukwa ichi, mankhwalawa amaikidwa mufiriji, komabe, amaletsedwa kuti asafe. Cholembera cha syringe pambuyo chogwiritsidwa ntchito chimatha kusungidwa kwa milungu isanu ndi umodzi, kutentha osapitirira 30 digiri Celsius. Mukatha kugwiritsa ntchito, jekeseni wa subcutaneous makonzedwe ayenera kutsekedwa bwino ndi chipewa kuti athandizire yankho lake potetezedwa ku kuwala kozungulira. Moyo wa alumali ndi miyezi 30.

Malangizo apadera

Mukamagwiritsa ntchito Levemir, ndikofunikira kusunga mosamalitsa kuchuluka kwa mankhwala. Kuchuluka kwa mlingo, chiwopsezo cha kukhala ndi hypoglycemia chimakulanso. Kuphatikiza apo, kuchita masewera olimbitsa thupi kwambiri kapena kudya moperewera kumathandizira kuchepetsa shuga. Simungathe kulowa mankhwalawa kudzera m'mitsempha, chifukwa izi zimangokulitsa vutolo ndikupangitsa kwambiri hypoglycemia. Anthu omwe amagwira ntchito ndi ma process omwe amafunikira chidwi chochulukirapo komanso kuwongolera TS akuyenera kuwunika kuchuluka kwa glucose m'magazi ndikutchingira kukula kwa hyperglycemia ndi hypoglycemia, chifukwa ndi ma pathologies awa kuthamanga kwazomwe zimachitika komanso kuthekera kwazomwe zimayang'ana zimalephera.

Kodi zikuwonekabe zosatheka kuchiritsa matenda ashuga?

Poona kuti mukuwerenga izi tsopano, kupambana polimbana ndi shuga wambiri sikuli kumbali yanu.

Ndipo mudaganizapo kale za chithandizo kuchipatala? Ndizomveka, chifukwa shuga ndi matenda oopsa, omwe, ngati sanapatsidwe, amatha kufa. Udzu wokhazikika, kukodza mwachangu, masomphenya osalala. Zizindikiro zonsezi mumazidziwa nokha.

Koma kodi ndizotheka kuchitira zomwe zimayambitsa m'malo mothandizira? Timalimbikitsa kuwerenga nkhani yokhudza matenda aposachedwa a shuga. Werengani nkhani >>

Zina

Mankhwala a Levemir Flexpen (opangidwa ndi NovoNordisk, Denmark) ndi mtundu wa insulin ya anthu pakuwongolera kuchuluka kwa shuga m'magazi a shuga odwala matenda ashuga. Muli woyenera kuyenda.

Malinga ndi International Statistical Classization of Matenda ndi Mavuto A Zaumoyo, 1989. (ICD-10), Levemir Flexpen adzagwiritsidwe ntchito pazotsatirazi:

• E 10 - Type 1 shuga mellitus - olembetsedwa, otsutsana ndi unyamata, kapena ali ndi vuto la ketosis,
• E 12 - Matenda a shuga a shuga omwe amadalira insulin omwe amagwirizana ndi zakudya,
• E 13 - Mellitus woyipa wa mtundu woyamba wa mitundu ina,
• E 14 - Matenda a shuga omwe amadalira insulin.

Matenda a shuga omwe ali ndi kuchuluka kwa shuga mu mtundu woyamba ndi amodzi mwa malo otsogola pakati pa matenda amtundu wa endocrine omwe ali ndi zotsatirapo zoipa kwa thupi. Hyperglycemia imakhudza kwambiri moyo, kukakamiza wodwalayo kutsatira kwambiri zakudya, zolimbitsa thupi, kudya ndi kukonza milingo yamagazi mothandizidwa ndi jakisoni wambiri wa insulin. Komabe, sizotheka nthawi zonse, makamaka ngati mwana wadwala matenda ashuga.

Malinga ndi kafukufuku, mpaka 80% ya ana posachedwa amabwera ku dipatimenti yodzidzimutsa kuti adziwe matenda a matenda ashuga a ketoacidosis. Zomwe zimayambitsa matenda a ketoacidosis kapena matenda a shuga ndi awa:

• Kuphwanya zakudya, makamaka kugwiritsa ntchito zakumwa zosokoneza bongo, zakumwa zoledzeretsa,
• kuphwanya dongosolo la insulin - kulumpha jakisoni wotsatira, kukhazikitsa mankhwala omwe atha ntchito kapena osasamala,
• kupsinjika kwa malingaliro
• kukana insulini chifukwa cha kusintha kwamphamvu kwamankhwala ndi thupi.
• matenda opatsirana
• kutenga corticosteroids kapena okodzeya,
• njala kapena kusowa kwamadzi,
• kuvulala ndi zina.

Makamaka, zovuta za shuga zimakhala kunja kwanyumba, komwe mankhwala ndi zida zina (syringes, mankhwala ophera tizilombo) zimasungidwa nthawi zambiri. Nthawi zambiri, hyperglycemia imachitika ngati munthu sangathe kufika panyumba nthawi yake (mayendedwe apamsewu, kuthamangitsa) pazifukwa zosiyanasiyana. Zotsatira za hyperglycemia yofatsa, yoyambitsidwa ndi zifukwa zomwe tafotokozazi, osapezeka nthawi, imatha kukhala yopanda pake munthawi yake, yomwe, imatha kubweretsanso jakisoni wina.

Kusokonezeka chifukwa cha hyperglycemia kumatha kubweretsanso kulephera kuchita ziwonetsero zosavuta ndi syringe ndi kusonkhanitsa / kuyendetsa mankhwala, makamaka ana, odwala okalamba, anthu ofooka ndi matenda, kuvulala kapena zina.

M'mikhalidwe imeneyi, ndikofunikira kuti wodwala wodwala matenda ashuga azikhala ndi inshuwaransi m'njira yoyenera ya jakisoni, amene amachepetsa zovuta pamene jekeseni pamalo osavomerezeka, popanda kuchita ziwonetsero zomwe zimafunikira pakubaya jakisoni wa mankhwala.

Makamaka pazinthu zotere, mankhwalawa Levemir Flexpen anapangidwa.

Mankhwala

Detemir insulin ndi chida chowongolera chotsalira pa insulin yaumunthu, chimakhala ndi mphamvu yayitali m'thupi.

Mankhwalawa amapangidwa pogwiritsa ntchito unusellular microscopic fungi. M'malo olembetsera, magawo awiri kapena kupitirirapo deoxyribonucleic acid amakonzedwanso (kuphatikizidwa). Chifukwa chake, mankhwalawa Levemir Flexpen ndiwopangidwa kuchokera ku genetic engineering.

Zotsatira zake zimapanga insulin. Chifukwa chogwirizana ndi mapuloteni a albumin, insulin yotsekemera imatengedwa ndi minofu yayitali kwambiri. Ndipo mpaka italowa mu cell, mawonekedwe a insulin awa amakhala osungunuka.

Mbali yodziwika bwino ya insulin yotchedwa recombinant insulin ndi kusakhalako kwa mfundo zofunika kwambiri chifukwa zimakomedwa ndi thupi, zomwe sizikuphatikizira kuukira kwamphamvu kwa hypoglycemia, ndipo zimakhudza thanzi la wodwalayo komanso thanzi.

Kafukufuku (M. Vardi, 2008, M. Monami, 2009, A. Trikko, 2014 - zoyerekeza 39 zomwe zasinthidwa mwachidziwitso) zikuwonetsa kuti insulin yokhala ndi nthawi yayitali imagwira ntchito kwambiri komanso ndiyotetezeka kwa wodwala matenda ashuga a mtundu woyamba.

Asayansi akhazikitsa mfundo yoti kugwiritsa ntchito Levemir sikumapangitsa kuti wodwalayo azichulukitsa nthawi, ndipo zimachepetsa kwambiri vuto la nocturnal hypoglycemia.

Detemir imakhala yovomerezeka kwa maola 24 (chizindikiro chodalira mlingo). Ndi kukhazikitsidwa kwa kawiri pa tsiku, kukula kwa shuga m'magazi kumatheka mkati mwa masiku awiri.

Kuchulukitsa kwa mankhwalawa m'magazi kumafikiridwa ndi ola lachisanu ndi chiwiri pambuyo pobayira.

Botolo limodzi la Levemir Flexspen lili ndi magawo 100,00 a insulin yaumunthu ya Detemir pa millilita yankho. Voliyumu yonse ya mankhwalawa ndi mamiliyoni 14.2.

Khola limodzi la syringe limakhala ndi ma milliliters atatu a solution (300.00 magawo a insulin detemir).

1 unit ya insulin detemir ilingana ndi 1 unit ya ME (insulin ya anthu), ndipo ili ndi mamiligalamu 0,142 a insulin.

Zowonjezera: propane-1,2,3-triol, carbolic acid, polymethylene-meta-cresol sulfonic acid, nthaka acetate, sodium dihydrogen phosphate, solution ya isotonic, caustic koloko, madzi osungunuka.

Zizindikiro zambiri

Ma insulin mawonekedwe amtundu wa mankhwala:

• mu mawonekedwe a monotherapy - kukonza shuga m'magazi odwala matenda a shuga amitundu yonse,
• kuphatikiza ndi othandizira a hypoglycemic othandizira mankhwalawa omwe amadalira shuga osadalira insulin omwe amayankha yotsika ku chithandizo chokhala ndi mapiritsi okha - mpaka magulu a shuga akhazikika amwazi. Kuphatikiza apo, mankhwalawa amasinthidwa kuti apitirize kugwira ntchito.

Gulu lamavuto

Momwe mankhwala amathandizira kuti agwirizane ndi maphunziro owonjezera a biochemical akuphatikizapo:

• kuchepa kwa michere ya impso kapena chiwindi,
• kufooka kwambiri kwa albumin kapena matenda osachiritsika,
• kusamutsa wodwala kuti atuluke ku insulin ya mtundu wina ndi chikhalidwe chake chikuyenera kuchitika moyang'aniridwa ndi dokotala.

Odwala ochokera m'magulu ambiri omwe ali pachiwopsezo cha hypo- ndi hyperglycemia amayenera kuwerengera kuchuluka kwa magazi, ndikutsatiridwa ndi kuchuluka kwa mankhwalawa.

Kuphatikizidwa ndi glitazones (rosiglitazone, pioglitazone) kungayambitse kulephera kwa minofu yamtima. Kugwiritsa ntchito pamodzi mankhwala onse awiriwa pamafunika kuyang'aniridwa kuchipatala.

Kuchita zinthu zina

Levemir Flexpen iyenera kuphatikizidwa ndi chisamaliro chapadera ndi mankhwala omwe amakhudza shuga pakuwunika kwa seramu.

Mankhwala okhala ndi vuto la hypoglycemic:

• hypoglycemic mu mawonekedwe apiritsi,
• mankhwala ena omwe amachepetsa kuwonongeka kwa ma monoamines (kuphatikizapo antidepressants),
• beta adrenoline blockers,
• othandizira othandizira mtima kukanika komanso matenda oopsa, kulepheretsa kutembenuka kwa angiotensin a mtundu woyamba kupita wachiwiri,
• othandizira salicylic acid, kuphatikizapo aspirin,
• anabolics
• mankhwala antifungal ndi anthelmintic,
• milomo
• Vitamini B6
• sulfonamides,
• masamba a tiyi
• Zinthu zopangidwa ndi lithiamu.

Mankhwala omwe akufuna kuwonjezeka kwa jakisoni wa insulin:

• kulera kwamlomo
• thiazide okodzeya,
• prolactin suppressants,
• glucocorticosteroids,
• mankhwala omwe amakhudza chithokomiro.
• mankhwala a adrenomimetic
• androgens ndi somatropin,
• calcium blockers.

Kugwiritsa ntchito ma adrenergic blockers kungakhalenso kolakwika ponena za kuwonekera kwa hypoglycemia.

Mankhwala a Hormonal antitumor, komanso mowa, amachita mosayembekezeka pamlingo wamagazi m'magazi.

Zinthu zina zomwe zimapangidwa ndi theol kapena sulfite zimatha kuwononga insulin ndipo siziyenera kusakanizika ndi kulowetsedwa.

Zotsatira zoyipa

Nthawi zambiri zovuta zomwe zimadziwika ndizovuta zamankhwala a insulin ndipo, pafupifupi, kupezeka kwawo kuli pafupifupi 12% ya chiwerengero chonse cha odwala. Zotsatira zoyipa kwambiri za mankhwala ziyenera kuganiziridwa ngati kukula kwa hypoglycemia (kwambiri hypoglycemia - pafupifupi 6% ya chiwerengero chonse cha odwala).

Thupi lanu siligwirizana pakamvedwe ka mankhwala nthawi zambiri limapangika, monga kutupa, redness, kuyabwa, kutupa kwa khungu ndi urticaria. Monga lamulo, kudutsa palokha pakatha milungu iwiri kuyambira chiyambi cha mankhwala.

Chiyambireni cha mankhwala nthawi zambiri chimagwirizanitsidwa ndi kusokonezeka kwa mitsempha yam'maso, komanso neuropathy yamankhwala okhala ndi mbali yayikulu ya kupweteka. Zochitikazi ndizosintha.

M'munda wamtima ndi kuzungulira kwa dongosolo: hypoglycemia imawonedwa kwambiri, tachycardia ndi chizindikiro chotsatana ndi hypoglycemia.

M`mimba thirakiti ndi dongosolo excretory: Zizindikiro limodzi ndi hypoglycemia - "nkhandwe" njala, nseru.

M'munda wamawonedwe ndi kumva: kusintha kwa kayendedwe ka magazi mu retina komwe kumalumikizidwa ndi matenda ashuga, mawonekedwe opindika.

Mu gawo la chapakati mantha dongosolo: nthawi zina mitsempha ya malekezero amakula.

M'munda wa dermatology: dystrophy ya subcutaneous adipose minofu pa malo a jekeseni sichimawonekera.

Thupi lawo siligwirizana: Nthawi zambiri - urticaria, khungu kusintha kwanuko malo jakisoni, kawirikawiri - kutupa kwa kupuma thirakiti.

Malo osungira

Syringe ndi kapisozi, yomwe imatsegulidwa ndikugwiritsa ntchito, iyenera kusungidwa pamoto kutentha, kutali ndi magwero owunikira, kuchokera kwa ana, koma osapitirira masiku makumi anayi.

Makapisozi a syringe osatsegulidwa azisungidwa mufiriji kutentha kwa madigiri 2-8 Celsius, kutali ndi chipinda cha mafiriji. Osatinso kuzizira.