Alpha Lipoic Acid

Dzinali lidalandira chinthu cha antioxidant chomwe chimapezeka mkati mwa khungu la munthu. Amadziwikanso kuti Vitamini N kapena thioctic acid.

Zokhudza chilengedwe, mtundu wa asidi wofanana ndi mavitamini, michere. Ndi alpha lipoic acid, womwe umapezeka mkati mwa khungu lililonse, umatulutsa mphamvu ndikuthandizira kuchepetsa kuchuluka kwa shuga m'thupi.

Mapangidwe a vitamini awa amagwiritsidwa ntchito ngati zowonjezera, chifukwa amadziwika kuti ndi amodzi mwa antioxidants amphamvu kwambiri.

Chifukwa cha zinthu zotere, zosintha izi zitha kuchitika mthupi la munthu:

Tinthu tosakhazikika (makamaka tinthu tomwe timatulutsa oksijeni) sizimalowerera.
Ma antioxidants achilendo adzachira: Vitamini E, Vitamini C, Glutathione (tripeptide).
Chiyambi cha ma radicals (chaulere) chitha kuchepa chifukwa cha kutsekemera kwa zinthu zapoizoni.
Kuchuluka kwa shuga kudzachepa.
Kupangaabolism kudzakhala bwino.
Kutulutsa thupi kumachitika.

Akatswiri akuti kumwa mankhwalawa limodzi kuphatikiza kumachepetsa kwambiri ma migraines, kubwezeretsa kukumbukira komanso kuteteza thupi ku radiation.

Zizindikiro zogwiritsidwa ntchito

Vitamini N amatengedwa ndi anthu omwe ali ndi shuga wambiri, makamaka ndi mtundu woyamba komanso wachiwiri wa zovuta. Mankhwalawa amatha kuthandizidwa kuti ajambulidwe ngati jakisoni kapena pakamwa. Kuphatikiza apo, malinga ndi malangizo, mankhwala a alpha lipoic angatengedwe ngati munthu ali ndi mitundu yotsatila yamatenda:

Imfa yamitsempha yama mitsempha (yowonongeka ndi mitsempha yamapweya).
Pakuchepetsedwa kowongolera kusintha mphamvu.
Ngati mukufuna kuchotsa owonda kwambiri.
Ndi matenda a chiwindi.
Pa matenda a chiwindi kapena matenda a Botkin.
Pambuyo poyizoni.
Ndi kuledzera kapena hyperlipidemia.

Ndikofunika kufunsa katswiri musanayambe kugwiritsa ntchito, popeza mankhwalawa amatha kukhala ndi zotsatirapo zake:

Chifuwa (zotupa, ming'oma, kukhumudwa kwa anaphylactic).
Kuchulukitsa kwachulukira.

Simungagwiritse ntchito antioxidant iyi ngati pali zilonda zam'mimba kapena zilonda zam'mimba, gastritis, pakati, kuyamwitsa. Amaletsedwanso kugwiritsa ntchito asidi ngati chowonjezera kwa mwana yemwe sanakwanitse zaka zisanu ndi chimodzi. Izi zophwanya lamulo ziyenera kukumbukiridwa kuti asiye kugwiritsa ntchito alpha-lipoic acid munthawi yake komanso osayambitsa zovuta.

Malangizo ogwiritsira ntchito

Monga mankhwala ena ngati vitamini, alpha lipoic acid imakhala ndi mlingo wake wa anthu omwe amamwa ngati prophylaxis. Zomwe zimachitika tsiku ndi tsiku zimakhudzidwa ndi msinkhu wa munthu:

Kufikira zaka 15, 11-24 mg ndizokwanira anthu. zinthu.
Paukalamba, 31-49 mg.

Kuti zotsatira zake zisagwiritsidwe ntchito dithiooctanoic acid ikhale yolondola, popeza nthawi ndiyofunika kusiya zakumwa zoledzeretsa zilizonse.

Ngati mankhwalawa adalembedwa kwa munthu yemwe ali ndi matenda a shuga, muyenera kumwa ndi chakudya, 1 nthawi patsiku, kuchuluka kwa 500-600 mg. Mukamamwa pakamwa, acidyo imalowa mwachangu m'thupi ndikulimbitsa maselo. Musanagule mankhwalawa, ndibwino kukaonana ndi dokotala kuti mupeze zotsatirapo zabwino pazogwiritsa ntchito.

Ngati wodwala ali ndi matenda a shuga, ndiye kuti dokotala amamulembera kuti amwe mankhwala 50 mg masana:

Mukatha kudya kapena musanadye (m'mawa).
Pambuyo pa maphunziro akuthupi.
Pa chakudya chomaliza.

Ubwino wa Thioc Acid

Alpha-lipoic acid imakonda kuonedwa ngati chinthu chokhala ndi Vitamini, monga momwe imawonekera m'thupi lokha. Ili ndi zinthu zingapo zothandiza kwa anthu:

Chimateteza maselo chifukwa chakutha kudutsa m'mimba yonse.
Amathandizira mavitamini osiyanasiyana mthupi.
Amasintha kagayidwe.
Ochepetsa insulin.
Amachepetsa cholesterol.

Metformin yokhudza matenda ashuga

Kuphatikiza apo, ndizosatheka kuti musazindikire phindu la chinthucho ndipo ngati mukufuna, mutaya mapaundi owonjezera. Chochita ngati ichi cha Vitamini chimakhudzidwa ndikuwotcha kwamafuta, zomwe zimathandizira kuti magawo a mafuta alipo. Kukhala m'thupi la munthu, kumawonjezera kagayidwe kazakudya, ndikuwonjezera mphamvu.

Thioctic acid imagwiritsidwanso ntchito nthawi zambiri mu cosmetology. Apa imagwiritsidwa ntchito ngati njira yakunja yopangidwanso, kusintha maonekedwe abwino, kukhalabe ndi mawu. Ngati pali matenda apakhungu, ndiye kuti mafuta omwe amapangidwa pamaziko a lipoic acid amathandiza kuthetsa njira zotupa.

Zotsatira zoyipa za Alpha Lipoic Acid

Kuphatikiza pazabwino zomwe chinthuchi chimakhala nacho, mulingo wambiri utatha, thupi la munthu limatha kugwira ntchito bwino, zomwe zimapangitsa zotsatirazi:

Kupanikizika kumakula.
Thupi lawo siligwirizana.
Kutembenuka kumatha kuchitika.
Chimbudzi chikukula.
Mutu wapafupipafupi.
Mawonekedwe ofooka.

Tiyenera kukumbukira kuti mothandizidwa ndi mankhwalawa ndizosatheka kuti muchepetse matenda ashuga, chifukwa mankhwalawa amangokhala ndi kanthawi kochepa, komwe amayenera kubwerezedwa pafupipafupi.

Alpha Lipoic Acid wa Matenda A shuga

Mankhwalawa amathandiza kwambiri shuga wambiri, yemwe amayamba kudwala matenda a shuga m'thupi la munthu. Acid imabwezeretsa mitsempha, potero imakulitsa mphamvu zomverera zotayika chifukwa cha zovuta izi.

Chifukwa cha chilengedwe chake, mapangidwe amtunduwu a mavitamini amachepetsa kuchuluka kwa shuga mu mtundu woyamba ndi wachiwiri wa matenda.

Ndikofunikira kutchera khutu kuti asidi amateteza kapamba, kukonza gawo la kulingalira kwa zigawo za mahomoni, ndikuwonjezera shuga. Kuphatikiza apo, prophylaxis yokhala ndi thioctacid acid ilola kuti maselo a pancreatic asungidwe koyambirira kwa matenda ashuga, potero amachotsa zovuta ndi chitukuko cha matendawa.

Mthupi la munthu wodwala, alpha-lipoic acid amatha kuchita zinthu zotsatirazi zochizira:

Amathetsa kuwoneka ngati ma radicals owopsa aulere, omwe angasokoneze njira yayitali komanso yopanda vuto la cell oxidation, potero kusintha thanzi ndikuchotsa kukula kwa matendawa.
Imathandizira ndikubwezeretsa mavitamini E, C, glutathione, coenzyme Q10.
Kuphatikiza zitsulo zowopsa ndikuchepetsa maonekedwe a ma radicals aulere.

M'zaka za zana la 20, mu 90s, mtundu uwu wa asidi unali m'gulu la vitamini B, koma pambuyo pake, titaphunzira za kapangidwe kake ka mankhwala, tinaganiza zosintha chinthuchi kukhala mavitamini osiyanasiyana.

Ndizotheka kuthana ndi neuropathy ndi lipoic acid, chifukwa imakhazikitsa magwiridwe antchito a minyewa yamitsempha. Kukopa kwamitsempha kumayendetsedwa bwino, potero kumawonjezera chidwi cha wodwalayo ndikuchotsa zosasangalatsa za zovuta.

Lipoic acid imatha kuthandizidwa limodzi ndi mankhwala ena a antidiabetesic (Thiolipon kapena Berlition). Muyeneranso kuyang'anira kudya kwanu, ndikuyang'aniridwa ndi dokotala pafupipafupi kuti, ngati kuli koyenera, azitha kuchepetsa kuchuluka kwa mankhwalawa omwe agwiritsidwa ntchito ngati zinthu zikuyenda bwino.

Madokotala amafufuza

Popeza mankhwalawa amagwiritsidwanso ntchito pakuchepetsa thupi, madokotala ambiri alibe lingaliro lomveka pankhani yogwiritsira ntchito. Chokhacho chomwe samagwirizana mosagwirizana ndikuti popanda zakudya zoyenera komanso katundu wochita masewera. Ndikosatheka kuyembekezera zabwino kuchokera ku chinthu ichi.

Mankhwala odziwika kwambiri okhala ndi alpha lipoic acid ndi turboslim, yomwe imakhala ndi l cartin. Katunduyu amakhala ndi zotsatira zabwino osati pazikhalidwe zakunja zokha, komanso amakhalanso ndi mkati.

Munthu yemwe ali ndi matenda a shuga sataya thupi akamamwa lipoic acid, chifukwa amachepetsa thupi komanso kudya kwathunthu. Ngakhale izi zimapangidwa ndi thupi lokha, popanda zinthu zina zowonjezera sizokwanira kuti zithetse mokwanira kukonza mkhalidwe wodwala wodwala matenda ashuga.

Insulin Lantus Solostar

Kuti muwonjezere asidi zomwe zili mthupi, mutha kugwiritsa ntchito:

Ng'ombe
Mpunga
Nyama ikudya,
Sipinachi
Mkaka
Broccoli ndi ena.

Palinso ma bioadditives a pharmacy omwe amakhala ndi asidi omwe amathandizira kuchotsa zopitilira muyeso mthupi. Zonsezi ndizofunikira, choyambirira, kupewa matenda osakhazikika, chifukwa chake sizikhala ndi vuto lililonse pazokhudza thanzi.

Ngati mumadya moyenera, phunzirani zolimbitsa thupi pafupipafupi, kusiya zizolowezi zoipa, ndiye kuti mutha kukonza bwino thanzi lanu, kutaya mavuto osasangalatsa ndikusiya kuvutika chifukwa chambiri.

Ndikofunika kukumbukira kuti njira yokhayo yophatikizira kuchepetsa thupi ndi alpha lipoic acid ndi othandiza. Popanda zakudya zoyenera, kupita pafupipafupi ku masewera olimbitsa thupi - izi sizingatheke.

Monga mankhwala a bioadditives (BAA) ndi mankhwala okhala ndi alpha-lipoic acid, mutha kugula:

Berlition (wogulitsidwa m'mapiritsi komanso chogwiritsira ntchito jekeseni wamkati).
Lipothioxone (wogulitsidwa mumapiritsi ndikugogomezera).
Lipamide (pamapiritsi).
Lipoic acid (yankho ndi mapiritsi).
Thiogamm (khazikika, miyala, njira).
Espa-Lipon (onjezera ndi magome).
Thiolipone (khazikika).
Thioctacid BV (mapiritsi).

Mankhwala amagwiritsidwa ntchito kuwonjezera kukhulupirika kwa wodwalayo, kuwonjezera nthawi ya moyo. Zakudya zowonjezera zimagwiritsidwa ntchito makamaka popewa zina kuti muwonjezere kuchuluka kwa asidi m'maselo. Mankhwala ena a lipoic acid amapezeka pazakudya zina:

Kuchokera kwa Solgar
kuchokera ku NSP,
kuchokera ku DHC,
Alpha DZ-Teva,
Gastrofilin Plus
Nache Bounty ndi ena.

Ngati munthu ali ndi vuto la kuphatikiza mankhwalawo, angathe kupatsidwa mankhwala okhala ndi mankhwalawo mu mankhwalawo omwe angakumane ndi zomwezi: Thiogamma, Alpha-lipon, Lipamide, Thioctacid. Monga analogue, mutha kugwiritsa ntchito presinic acid

Zabwino koposa zonse, musanagule, funsani dokotala yemwe amayang'anira njira zochiritsira kuti muchepetse chiopsezo chotsatira.

Kodi ndi bwino kumwa mankhwala ena a acid omwe ndi acidic

Kugwiritsa ntchito asidi mothandizidwa ndi mankhwala, nthawi yake imakhala yochepa, chifukwa theka lake limakhala mkati mwa mphindi 30. Nthawi yayitali kwambiri yomwe ili mthupi imafika mphindi 60.

Mankhwalawa akaperekedwa kudzera m'mitsempha, amayamba kuchita bwino chifukwa mankhwalawo amalowetsedwa mthupi samayamba kugwira ntchito, potenga nthawi yayitali mpaka atayamba kukwaniritsa ntchito zake, chifukwa chake, mankhwalawa amakhala kwakanthawi mthupi.

Zomwe muli

Kuphatikiza pa kumwa mankhwalawa monga zowonjezera, mutha kuwonjezera kuchuluka kwa alpha lipoic acid pogwiritsa ntchito zinthu zachilengedwe. Kuchuluka kwake kumapezeka pazinthu zanyama monga - chiwindi, mtima, impso. Komanso, kuchuluka kwake kumapezekanso m'miyendo: nyemba, mphodza, nandolo. Kuphatikiza apo, gawo lina la asidi limatha kupezeka ndikudya nthochi. Mwina sangakhale mpunga kapena mkaka.

Mwa kudya zochuluka zokwanira pamwambazi, sizotheka kungobwezeretsanso asidi, komanso kudzipatula ku zovuta zomwe zingachitike chifukwa cha kuchuluka kwake kosakwanira:

Nthawi ndi nthawi kapena kupweteka kwa mutu, polyneuritis, chizungulire,
Matenda a mtima
Minofu kukokana
Mavuto a chiwindi ndi ena.

Ndikofunikira kubwezeretsa kuchuluka kwa alpha-lipoic acid mthupi tsiku ndi tsiku, chifukwa amathandiza kukonza thanzi. Komabe, musanagwiritse ntchito mankhwala aliwonse, ndikofunikira kuphunzira malangizo mosamala, choyamba, lankhulanani ndi dokotala.

Matenda a shuga

Ndi matenda a shuga omwe akupita patsogolo komanso pang'onopang'ono akamakula m'magazi a shuga, mphamvu yamanjenje imawonongeka. Mavuto amayamba chifukwa cha kupangika kwa zinthu za glycolised zomwe zimakhudza misempha. Chifukwa cha kuchuluka kwa shuga m'magazi, kufalikira kwa magazi kumawonjezereka, chifukwa, kukonza minyewa kumachepa.

Kuzindikiritsidwa kwa matenda a diabetesic neuropathy kungachitike ngati pali zizindikiro zoyenera:

kudumphira m'magazi,
dzanzi la miyendo
kumva m'miyendo, mikono,
kupweteka
chizungulire
mavuto ndi erection mwa amuna
mawonekedwe a kutentha kwadzuwa, kudzimbidwa, kukhumudwa kwambiri, ngakhale ndi chakudya chochepa chomwe chidadyedwa.

Kuti mupeze matenda olondola, ma reflexes amayendera, kuthamanga kwa mitsempha kumayesedwa, electromyograph imapangidwa. Mukatsimikizira neuropathy, mutha kuyesa kusintha matenda pogwiritsa ntchito α-lipoic acid.

Zosowa zathupi

Lipoic acid ndi mafuta acid. Ili ndi kuchuluka kwa sulufule. Ndi madzi ndi madzi sungunuka, amatenga nawo mbali pakapangidwe ka cell membrane ndipo amateteza maselo a cell ku pathological zotsatira.

Lipic acid amatanthauza ma antioxidants omwe amatha kuletsa zotsatira za kusintha kwaulere. Amagwiritsidwa ntchito pochiza matenda ashuga a polyneuropathy. Katunduyo ndi wofunikira chifukwa:

amatenga nawo mbali pakuchepa kwa shuga ndikuchotsa mphamvu,
imateteza maselo a cell ku zotsatira zoyipa zama radicals aulere,
ili ndi mphamvu ya insulin: imakulitsa zochitika zaonyamula shuga mu cytoplasm of cell, ikuthandizira njira yamatenda a glucose omwe amapangidwa ndi minofu,
ndi antioxidant wamphamvu, wofanana ndi mavitamini E ndi C.

Ichi ndi chimodzi mwazinthu zabwino kwambiri zothandizira odwala matenda ashuga. Nthawi zambiri amalimbikitsa poika mankhwala okwanira. Amawerengedwa kuti ndi antioxidant wabwino, chifukwa asidi awa:

odzipereka ku chakudya
Amasinthidwa maselo kuti akhale omasuka,
kawopsedwe kochepa
ili ndi ntchito zosiyanasiyana zoteteza.

Mukamamwa, mutha kuthana ndi mavuto angapo omwe amadza chifukwa cha kuwonongeka kwa makulidwe amtundu wa oxidative.

Zokhudza thupi la odwala matenda ashuga

Mthupi, thioctic acid imagwira ntchito zotsatirazi:

imalepheretsa zowopsa zaulere zamagetsi ndikuisokoneza njira ya makutidwe ndi okosijeni,
imabwezeretsa ndikupangitsa kuti igwiritsenso ntchito antioxidants amkati: mavitamini C, E, coenzyme Q10, glutathione,
chimamangirira zitsulo zakumwa zoziziritsa kukhosi ndikuchepetsa kupanga ma free radicals.

Asidi omwe atchulidwa ndi gawo limodzi lachitetezo cha thupi. Chifukwa cha ntchito yake, ma antioxidants ena amabwezeretsedwa, atha kutenga nawo gawo mu kagayidwe ka nthawi yayitali.

Malinga ndi dongosolo la biochemical, chinthu ichi ndi chofanana ndi mavitamini a B. Mu 80-90s ya zaka zapitazi, asidi awa amatchedwa mavitamini a B, koma njira zamakono zapangitsa kuti amvetsetse kuti ili ndi mitundu yosiyanasiyana ya biochemical.

Acid imapezeka mu ma enzymes omwe amathandizira kukonza zakudya. Ikapangidwa ndi thupi, kuchuluka kwa shuga kumachepa, ndipo ndizofunikira kwambiri kwa odwala matenda ashuga.

Chifukwa cha antioxidant zotsatira ndi kumangika kwa ma radicals aulere, zovuta zawo pazovuta zimalepheretsedwa. Thupi limachepetsa kukalamba ndipo limachepetsa kupsinjika kwa oxidative.

Acid iyi imapangidwa ndi minofu ya chiwindi. Amapangidwa kuchokera ku chakudya chomwe chikubwera.Kuti muwonjezere kuchuluka kwake, ndikofunikira kugwiritsa ntchito:

Koma pazinthu, izi zimagwirizanitsidwa ndi amino acid a mapuloteni (ndiwo, lysine). Ili ndi mtundu wa R-lipoic acid. Kuchulukitsa kwakukulu, antioxidant iyi imapezeka mu ziwalo za nyama zomwe zimagwira ntchito kwambiri. Kuzungulira kwakukulu, kumatha kupezeka impso, chiwindi ndi mtima.

Pokonzekera thioctic acid, imaphatikizidwa mwaulere mawonekedwe. Izi zikutanthauza kuti sizimagwirizana ndi mapuloteni. Mukamagwiritsa ntchito mankhwala apadera, kuchuluka kwa asidi m'thupi kumawonjezera nthawi 1000. Ndikosatheka kupeza 600 mg pazinthu izi kuchokera ku chakudya.

Akonzekereratu kukonzekera kwa lipoic acid a shuga:

Musanagule chinthu, funsani ndi dokotala.

Therapy regimen kusankha

Popeza mwasankha kusintha magwiritsidwe a shuga ndi ziwalo ndi machitidwe mothandizidwa ndi lipoic acid, muyenera kumvetsetsa dongosolo la kudya. Zinthu zina zimapezeka mwanjira ya mapiritsi kapena makapisozi, zina mwa njira yothetsera kulowetsedwa.

Pazifukwa zodzitetezera, mankhwalawa amatchulidwa ngati mapiritsi kapena mapiritsi. Iwo aledzera katatu patsiku kwa 100-200 mg. Ngati mumagula mankhwalawa muyezo wa 600 mg, ndiye kuti mlingo umodzi patsiku uzikhala wokwanira. Mukamamwa zowonjezera ndi R-lipoic acid, ndikokwanira kumwa 100 mg kawiri patsiku.

Kugwiritsa ntchito mankhwala molingana ndi chiwembuchi kungalepheretse zovuta za matenda ashuga. Koma muyenera kumwa mankhwalawa kokha pamimba yopanda kanthu - ola limodzi musanadye.

Mothandizidwa ndi asidi, mutha kuyesa kuchepetsa kuwonetsa kwa zovuta monga matenda a shuga. Koma chifukwa cha izi, kayendetsedwe ka intravenous mu mawonekedwe a njira zapadera m'malo ambiri kwanthawi yayitali.

Izi zimaphatikizidwa pakuphatikizidwa kwa ma multivitamini ena mpaka 50 mg. Koma kukwaniritsa zabwino pa thupi la munthu wodwala matenda ashuga komanso kudya acid mu Mlingo woterewu ndizosatheka.

Limagwirira zake mankhwala a matenda ashuga neuropathy

Zotsatira za antioxidant za lipoic acid zatsimikiziridwa ndi maphunziro ambiri. Amachepetsa kupsinjika kwa oxidative ndipo amathandizira thupi.

Ndi neuropathy, iyenera kuperekedwa kudzera m'mitsempha. Chithandizo cha nthawi yayitali chimapereka zotsatira. Mitsempha yomwe yakhudzidwa ndi kupitirira kwa shuga kuchokera pamaukidwe amkokedwe wa glucose pang'onopang'ono imachira. Njira yakukonzanso kwawo kwathandizira.

Anthu odwala matenda ashuga ayenera kudziwa kuti matenda ashuga a polyneuropathy amawoneka ngati matenda osinthika. Chachikulu ndikusankha njira yoyenera yothandizira ndikutsatira malangizo onse a madokotala. Koma popanda zakudya zapadera za carb, kuchotsa shuga ndi zovuta zake sizingathandize.

Kusankha mitundu ya mankhwala

Mothandizidwa ndi pakamwa pa cy-lipoic acid, kuphatikiza kwakukulu kumawonedwa pambuyo pa mphindi 30-60. Amatengeka mwachangu m'magazi, koma amathandizidwanso mwachangu. Chifukwa chake, mukamamwa mapiritsi, kuchuluka kwa shuga kumakhala kosasinthika. Kuzindikira kwa minofu kupita ku insulin kumawonjezeka pang'ono.

Ndi mlingo umodzi wa 200 mg, bioavailability wake ali pamlingo wa 30%. Ngakhale ndi chithandizo chopitilira masiku ambiri, chinthu ichi sichimadziunjikira m'magazi. Chifukwa chake, kuudya pofuna kuthana ndi kuchuluka kwa glucose ndikosatheka.

Ndi kukhuthala kwa mankhwalawa, mlingo wofunikira umalowa m'thupi mkati mwa mphindi 40. Chifukwa chake, ntchito yake imachulukitsidwa. Koma ngati chiphuphu cha matenda a shuga sichingatheke, ndiye kuti zilembo za matenda ashuga zidzabweza pakapita nthawi.

Anthu ena amalimbikitsa kumwa mapiritsi a zakudya a lipoic acid. Kupatula apo, amatenga nawo gawo pama metabolism a mafuta ndi mafuta. Koma ngati simutsatira mfundo zachakudya zoyenera, kukana masewera olimbitsa thupi, kusiya kulemera mopitirira muyeso ndimamwa mapiritsi sikugwira ntchito.

Zoyipa za chida

Kukonzekera mankhwala a thioctic acid nthawi zina kumachitika limodzi ndi kukonzekera zotsatira zoyipa:

mavuto a dyspeptic
mutu
kufooka.

Koma amawoneka, monga lamulo, ndi mankhwala osokoneza bongo.

Odwala ambiri amayembekeza kuti athetse matenda a shuga pomwa mankhwalawa. Koma kukwaniritsa izi ndizosatheka. Kupatula apo, siziunjikira, koma imakhala ndi nthawi yochepa yochizira.

Monga gawo la zovuta mankhwala, endocrinologist angalimbikitse kugwiritsa ntchito lipoic acid kwa odwala matenda ashuga. Chida ichi ndi antioxidant, chimachepetsa zovuta zoyipa zama radicals omasuka m'thupi.

Alpha lipoic acid pochiza ululu wa neuropathic odwala omwe ali ndi matenda osokoneza bongo

Neuropathy ndi zovuta zowonjezera za shuga mellitus, zomwe zimalumikizidwa ndi kulemala kwakukulu komanso kuchepa kwa moyo wa wodwalayo. Amadziwika kuti izi ndizotsatira za kuwonongeka kwa ziwiya zazing'ono komanso ma capillaries omwe amapereka mitsempha ya mitsempha. Cholinga chotsirizira ndikuwonjezereka kwa kupanga ma free radicals mu mitochondria chifukwa cha hyperglycemia.

Peripheral neuropathy imayamba ndi miyendo kenako imafalikira pang'ono mpaka kumiyendo yotsika. Kuphatikiza pa kuchepetsa kuchepa kwa chidwi, komwe kumakhala chiwopsezo cha zilonda zam'mapazi a neurotrophic, kupweteka kwa neuropathic kumatha kuchitika ngati chizindikiro cha polyneuropathy. Kupweteka kwamitsempha kumatha kuwonetsedwa ndikumverera kwa kugunda, kuwotcha komanso kulanda.

Pali chiwerengero chambiri chazomwe chikuwonetsa kuti kupezeka kwa zovuta zazovuta zam'magazi kumalumikizidwa ndi kupezeka kwa nthawi yayitali kwa kagayidwe ka shuga komanso kuuma kwake. Hyperglycemia induces imapanga kupanga ma free radicals a oxygen mu mitochondria (oxidative kapena oxidative nkhawa), yomwe imayambitsa kutsegulidwa kwa njira zinayi zodziwika za kuwonongeka kwa hyperglycemic: polyol, hexosamine, proteinasease C ndi AGE.

ALA idazindikirika mu 1951 ngati coenzyme mu tricarboxylic acid mzunguko (Krebs mzunguko). Zatsimikizira kuti ndi antioxidant wamphamvu yomwe akuti yachepetsa kuopsa kwa zotupa za micro- ndi macrovascular mu mitundu ya nyama.

Mu kafukufuku waposachedwa wokhudza odwala omwe ali ndi matenda a shuga 1, kusintha kwa mawonekedwe a AGE ndi zoletsa za hexosamine njira zikuwonetsedwa (Du et al. 2008).

ALA ngati njira yoletsera kuwonongeka kochokera ku hyperglycemia sikungakhale ndi zotsatira za analgesic, komanso kukonza ntchito ya mitsempha. Kuphatikiza apo, poyerekeza ndi mankhwala omwe amagwiritsidwa ntchito masiku ano, ALA ili ndi zovuta zochepa.

Zipangizo ndi njira zakufufuzira

Mu 2009, olemba kafukufukuyu adafufuza zolemba zogwirizana ndi zamasamba a MedLine, PubMed, ndi EMBASE. Kusaka kumeneku kunachitika pogwiritsa ntchito mawu akuti "lipoic acid", "thioctic acid", "shuga", "shuga mellitus".

Njira yofananira yosaka idagwiritsidwa ntchito pakusaka ku EMBASE. Zotsatira zakusaka kwa PubMed zidasefedwa kuti zisankhe mayesero oyendetsedwa mwachisawawa (ma RCT) ndi kuwunikira mwadongosolo.

Kodi mitundu yosiyanasiyana yamankhwala imagwira ntchito bwanji?

Mukukonzekera pakamwa, pazomwe zimapangitsa kuti munthu azitsatira mankhwalawa amawonekera pambuyo pa ola limodzi. Acid imatengedwa mwachangu ndikuchotsedwa m'magazi.

Chifukwa chake, pakachitika mapiritsi atsekeke komanso pambuyo pathupi, shuga sagwira. Pa mlingo umodzi wa 200 mg wa mankhwalawa, 30% bioavailability wa asidi amakhala ndi khalidwe.

Ngakhale atalandira mankhwalawa masiku ambiri, mankhwalawa sadziunjikira m'magazi a magazi. Chifukwa chake, madokotala salimbikitsa kuti mutengepo kuti muwongolere shuga.

Kukonzekera Mwakuthupi

Alphalipoic, kapena thioctic acid, ndi mankhwala achilengedwe omwe amapezeka pafupifupi muzakudya zonse. Zambiri mwa izo zimapezeka mu sipinachi, nyama yoyera, beetroot, kaloti ndi broccoli.

Amapangidwa tating'onoting'ono ndi thupi lathu. Katunduyu ali ndi gawo lofunikira kwambiri munjira za metabolic.

Akatswiri amati lipoic acid yamtundu wa 2 shuga imathandiza kuthandizira mitsempha yowonongeka ndipo imagwiritsidwa ntchito popewa njira za oncological. Komabe, mpaka pano palibe umboni wazomwe zimakhudza zotsatira zoyipa za mankhwala omwe amagwiritsidwa ntchito pochiza khansa.

1 General
2 Zokhudza thupi
3 Kumwa mankhwala

Zambiri

Lipoic acid imaphatikizidwa pakuphatikizidwa kwa mankhwala monga Thiolipon, Berlition, Neuro lipon, Lipamide. Mutha kugula ndalama ku pharmacy pamtengo wokwera ma ruble 700.

Kumwa mankhwala omwe ali ndi michere ya matenda a shuga ndikotheka, koma pokhapokha ngati chilolezo cha katswiri (katswiri wamkulu, katswiri wa zakudya kapena endocrinologist) atachita. Chowonadi ndichakuti mukamamwa mankhwalawa, pangafunikire kuti wodwalayo achepetse insulin.

Kukonzekera kumaphatikizapo 300 mpaka 600 mg ya lipoic acid.

Chodabwitsa cha mankhwalawa ndikuti ali ndi mphamvu yoteteza maselo. Acidic othandizira amalembera mavuto awa:

mtundu 2 shuga
kulephera kwa chiwindi
mtundu 1 shuga
coronary atherosulinosis,
kapamba
mafuta amchiwindi,
matenda a chiwindi
matenda ashuga polyneuropathy.

Kukonzekera ndi lipoic acid kumathandizira kuti muchepetse thupi, chifukwa amalimbikitsidwa kuti adye mtundu wachiwiri wa matenda osokoneza bongo omwe amayamba chifukwa cha kunenepa kwambiri. Komanso, ndalama zotere zimaperekedwa kuti zivomerezedwe pakudya kwamphamvu, pamene kudya kwa calorie kwa tsiku lililonse kukufika pa 1000.

Kugwiritsa ntchito lipoic acid ku matenda a shuga sikungakhale kopambanitsa. Mankhwala omwe amapezeka kwambiri mwa mapiritsi kapena mapiritsi okhala ndi 100, 200, 600 mg. Pali jakisoni wambiri wokapanda kuleka. Pakadali pano, palibe umboni uliwonse womwe ungafotokozere motsimikiza njira ina yogwiritsira ntchito.

Pankhani imeneyi, odwala ndi madokotala amakonda njira yoyankhulira pakamwa. Mlingo wovomerezeka tsiku lililonse ndi 600 mg. Mutha kumwa tabu 1. m'mawa kapena atatu Mlingo tsiku lonse. Zonse zimatengera zomwe wodwala amakonda.

Ndikofunika kudziwa kuti lipoic acid imataya gawo la chakudya chake pakudya. Chifukwa chake, ndikofunikira kugwiritsa ntchito ola limodzi musanadye kapena 2 mutatha kudya. Poterepa, mlingo wonse umayamwa bwino ndi thupi.

Mu pharmacology, lipoic acid kukonzekera shuga imayimiriridwa kwambiri, mitengo ku Russia ndi mayina omwe akufotokozedwa mndandanda pansipa:

Mapiritsi a Berlition - kuchokera 700 mpaka 850 ma ruble,
Mafuta ampira - kuchokera pa ruble 500 mpaka 1000,
Mapiritsi a Tiogamm - kuchokera ku 880 mpaka 200 ma ruble,
Thiogamm ampoules - kuchokera pa ma ruble 220 mpaka 2140,
Alpha lipoic acid m'mapiritsi - kuchokera 700 mpaka 800 ma ruble,
Makapisozi a Oktolipen - kuchokera ku ruble 250 mpaka 370,
Mapiritsi a Oktolipen - kuchokera ku ma ruble 540 mpaka 750,
Oktolipen ampoules - kuchokera 355 mpaka 470 rubles,
Lipoic acid pamapiritsi - kuchokera 35 mpaka 50 ma ruble,
Ma Nequolipen ampoules - kuchokera ku ma ruble 170 mpaka 300,
Makapisozi a Neuro lipen - kuchokera ku ruble 230 mpaka 300,
Thioctacid 600 T ampoules - kuyambira 1400 mpaka 1650 rubles,
Mapiritsi a Thioctacid BV - kuchokera 1600 mpaka 3200 rubles,
Mapiritsi a Espa-Lipon - kuyambira 645 mpaka 700 rubles,
Ma Espa-Lipon ampoules - kuyambira 730 mpaka 800 rubles,
Mapiritsi a Tialepta - kuchokera 300 mpaka 930 rubles.

Kugwiritsa ntchito lipoic acid pakuchepetsa thupi

Lipoic acid mu shuga amatha kuchepetsa ndikuwongolera thupi chifukwa cha anthu omwe ali ndi kunenepa kwambiri, zomwe ndizofunikira kwambiri kwa odwala matenda ashuga. Ndi odwala matenda ashuga omwe nthawi zambiri amadwala kunenepa kwambiri.

Lipoic acid mu shuga ndi imodzi mwanjira zodziwika bwino zothandizira matendawa. Zofunika kudziwa nthawi yomweyo kuti ndizothandiza kwambiri. Kuyambira 1990, mayesero angapo azachipatala apadziko lonse akhala akuchitika.

Kenako adatsimikiza kuti kugwiritsa ntchito mankhwalawa pothandiza kupewa matenda otsekemera. Ambiri a endocrinologists amalimbikitsa kugwiritsa ntchito mapiritsi a lentic acid tsiku lililonse kuti azikhala ndi glycemia wabwinobwino. Mankhwalawa adatchuka kwambiri ku USA ndi Europe, komwe kuyesedwa kunachitika.

Alpha lipoic acid ndi udindo wake m'thupi

Katunduyo adayamba kudzipatula ku chiwindi cha ng'ombe mu 1950. Kenako zidaganiziridwa kuti chinthucho chitha kukhala ndi tanthauzo pabwino la mapuloteni m'thupi. Tsopano ndikudziwika kuti ali m'gulu la acid acid ndipo ali ndi sulufuzi wophatikizika.

Kapangidwe kofananako kamatsimikiza kuthekera kwake kusungunuka m'madzi ndi mafuta. Amatenga nawo gawo popanga maselo a ma cell, amawateteza ku zotsatira za pathological.

Lipoic acid wa matenda ashuga ndiwofunika kwambiri chifukwa ali ndi zotsatirazi zochiritsa:

Amatenga nawo gawo lakuwonongeka kwa mamolekyulu a shuga, ndikutsatira kapangidwe ka mphamvu ya ATP.
Ndi amodzi mwa ma antioxidants achilengedwe amphamvu kwambiri limodzi ndi vit. C ndi E. Mu 1980-1990s, idaphatikizidwa ndi kuchuluka kwa mavitamini a B, koma maphunziro owonjezerawa adapangitsa kuti pakhale chidziwitso chofunikira cha kapangidwe ka zinthu.
Chimateteza maselo amthupi ku ma free radicals.
Ili ndi katundu wofanana ndi insulin. Zimawonjezera ntchito zaomwe zimanyamula shuga mkati mwa cytoplasm ndipo zimathandizira kuti shuga ayende bwino ndi minofu. Zachidziwikire, kuopsa kwa izi ndizotsika kwambiri kuposa zomwe zimachitika pancreatic hormone, koma izi zimaloleza kuphatikizidwa ndi zovuta za mankhwalawa pochiza matenda a shuga.

Chifukwa cha mawonekedwe ake, asidi wa lipoic (thioctic) tsopano akulimbikitsidwa kukhala imodzi mwazipangizo zofunikira kwambiri. Akatswiri ena asayansi amati ndikofunika kuudya kuposa mafuta am'madzi.

Kodi asidi amagwira ntchito bwanji m'matenda a shuga?

Mankhwala, lipoic acid imamveka kuti imatanthawuza antioxidant wamkati.

Ikafika m'thupi, imawonjezera glycogen m'chiwindi ndikuchepetsa kuchuluka kwa shuga m'magazi am'magazi, imalimbikitsa kukana kwa insulin, imatenga gawo la matenda a carbohydrate ndi lipid metabolism, imakhala ndi hypoglycemic, hypocholesterolemic, hepatoprotective ndi hypolipidemic.

Chifukwa cha mankhwalawa, lipoic acid nthawi zambiri amagwiritsidwa ntchito mtundu 1 komanso matenda ashuga a 2.

Ntchito mthupi

Pali mankhwala ambiri omwe ali ndi zinthu zofunika posamalira thanzi la thupi ndipo amagwiritsidwa ntchito ndi ma pharmacology ngati mankhwala omwe ali ndi matenda osiyanasiyana. Mwachitsanzo, vitamini-ngati chinthu lipoic acid, kuvulaza ndi mapindu ake zomwe zafotokozedwera pansipa.

Zotsatira za pharmacological

Ntchito yofunikira kwambiri m'thupi la munthu ndi kuphatikiza modabwitsa njira zosiyanasiyana zomwe zimayamba kuyambira nthawi yomwe mayi ali ndi pakati ndipo osasiya sekondi yamoyo wonse. Nthawi zina zimawoneka ngati zosamveka.

Mwachitsanzo, zinthu zofunika kwambiri pakapangidwe kazachilengedwe - mapuloteni - amafunikira mankhwala okhala ndi mapuloteni, otchedwa cofactor, kuti agwire ntchito moyenera. Ndi zinthu izi zomwe lipoic acid, kapena, momwe amatchedwanso, thioctic acid, ndiyayo.

Ndi gawo lofunikira la ma enzymatic ma protein omwe amagwira ntchito mthupi la munthu. Chifukwa chake, shuga akawonongeka, chinthu chotsiriza chimakhala mchere wa pyruvic acid - ma pyruvates. Ndi lipoic acid yomwe imakhudzidwa ndi njirayi.

Chifukwa cha kuthekera kwake kukonza kagayidwe ka cholesterol ndi ntchito ya chiwindi, lipoic acid imachepetsa mphamvu ya poizidine wa poogenic komanso amkati. Mwa njira, mankhwalawa ndi antioxidant yogwira, yomwe imatengera mphamvu yake yomanga ma radicals aulere.

Malinga ndi maphunziro osiyanasiyana, thioctic acid ali ndi hepatoprotective, hypolipidemic, hypocholesterolemic ndi hypoglycemic.

Zophatikiza zamafuta ngati izi za Vitamini zimagwiritsidwa ntchito pochita zachipatala kupereka mankhwala osokoneza bongo, kuphatikizapo zinthu zina, magawo ena a zochita za thupi. Ndipo kuphatikizidwa kwa lipoic acid mu jakisoni njira kumachepetsa kukula kwa zovuta zamankhwala.

Kodi mitundu ya mitundu ndi iti?

Mankhwala "Lipoic acid", mlingo wa mankhwalawa umaganizira zosowa zochizira, komanso njira yolembera thupi.

Chifukwa chake, mankhwalawa angagulidwe muma pharmacies m'mitundu iwiri - mu mapiritsi ndi mawonekedwe a yankho mu jekeseni ma ampoules.

Kutengera ndi omwe kampani yopanga mankhwala amapanga mankhwalawa, mapiritsi kapena makapisozi amatha kugulidwa ndi zomwe zili ndi 12,5 mpaka 600 mg wa yogwira mu 1 unit. Mapiritsi amapezeka mu zokutira zapadera, zomwe nthawi zambiri zimakhala ndi mtundu wachikaso.

Mankhwalawa amapezeka m'matumba ndi m'mapaketi okhala ndi mapiritsi 10, 50 kapena 100. Koma mu ampoules, mankhwalawa amapezeka mwa mawonekedwe a 3%. Thioctic acid ndi gawo limodzi la mankhwala ambiri okhala ndi zinthu zambiri komanso zakudya zamagulu ena.

Kodi kugwiritsa ntchito mankhwalawo kukuwoneka kuti?

Chimodzi mwazinthu zokhala ndi mavitamini ofunikira m'thupi la munthu ndi lipoic acid.

Zizindikiro zogwiritsidwa ntchito zimaganizira momwe zimagwirira ntchito ngati gawo limodzi la intracellular, ndizofunikira m'njira zambiri.

Chifukwa chake, lipoic acid, kuvulaza ndi maubwino omwe nthawi zina amayambitsa mikangano pagulu laumoyo, ali ndi zisonyezo zina zogwiritsidwa ntchito pochiza matenda kapena zikhalidwe monga:

coronary atherosulinosis,
tizilombo toyambitsa matenda a chiwindi (ndi jaundice),
matenda a chiwindi mu gawo yogwira,
dyslipidemia - kuphwanya mafuta kagayidwe, kamene kamaphatikizanso kusintha kwa lipids ndi lipoprotein yamagazi,
hepatic dystrophy (mafuta),
kuledzera ndi mankhwala, zitsulo zolemera, kaboni, kaboni tetrachloride, bowa (kuphatikiza mafuta akhungu),
pachimake chiwindi kulephera
chifuwa chachikulu pa zakumwa zoledzeretsa,
matenda ashuga polyneuritis,
zakumwa zoledzeretsa,
aakulu cholecystopancreatitis,
hepatic cirrhosis.

Mbali yayikulu yogwiritsira ntchito mankhwalawa "Lipoic acid" ndi chithandizo cha uchidakwa, poizoni ndi kuledzera, mankhwalawa a hepatic pathologies, dongosolo lamanjenje, ndi matenda a shuga. Komanso, mankhwalawa nthawi zambiri amagwiritsidwa ntchito pochiza khansa ndi cholinga chothandizira matenda.

Kodi pali zotsutsana ndi ntchito?

Kulimbitsa chitetezo chokwanira, kukulitsa kukana kwa thupi kumatenda osiyanasiyana.
Kutsitsa shuga.
Kuchepetsa kuthekera kwa matendawo.
Kupititsa patsogolo thanzi la munthu, kubweretsa thupi.

Malinga ndi zomwe apezeka, akutiicic acid amagwira ntchito bwino kwambiri ndi matenda a shuga a 2 kuposa okhala ndi matenda ashuga a mtundu woyamba. Izi ndichifukwa chakuti asidi amachepetsa misempha ya shuga popereka chitetezo cha pancreatic β-cell. Zotsatira zake, minofu kukana insulin yafupika.

Mankhwalawa amapezeka mu mawonekedwe a mapiritsi ndi mapiritsi a 100, 200, 600 mg.), Ampoules yankho la jakisoni mu mtsempha mulinso. Koma nthawi zambiri amamwa mankhwalawa pakamwa. Mlingo wa tsiku ndi tsiku ndi 600 mg., Waledzera katatu patsiku kwa mphindi 60. musanadye kapena pambuyo pa mphindi 120. pambuyo. Kumwa mankhwalawa osavomerezeka ndi zakudya, chifukwa kumamwa kwambiri.

Zizindikiro zakuchipatala

Kuphatikizika kwa mankhwala kwa thioctic pompano kuli mwa mawonekedwe a asidi wamafuta ndi sulufule. Imapezeka m'maselo onse amthupi momwe mphamvu imapangidwira. Poterepa, phula limatha kupangitsanso kuti awononge chiwongolero chaulere.

Alfa acid mu matenda a shuga amagwira ntchito m'mafuta ndi m'madzi. Ili ndi chiwonetsero chazonse zotetezera, kudzipereka kudzipatula kuti musachite zowongolera.

Mothandizidwa ndi lipoic acid, kuchepa kwa ma antioxidants otsala kumabwezeretseka.

Pomwe pali mankhwala ali ndi izi:

Zogulitsa ku chakudya.
Ntchito zoteteza.
Zoopsa zazing'ono.

Acid odwala matenda ashuga ndiwothandiza chifukwa amathandiza kugwetsa mamolekyulu a shuga. Matenda a antioxidant a shuga ali ndi katundu wofanana ndi insulin, chifukwa chake, amathandizira kuyamwa bwino kwa shuga ndi zimakhala.

Kuchuluka kwake kumakhala kocheperako poyerekezera ndi mahomoni a pancreatic, koma chifukwa cha kuwonekera kumene, asidi ali gawo la mankhwala osiyanasiyana ochizira matenda ashuga. Kukonzekera kwa mankhwalawa kumayikidwa ndi adokotala.

Mankhwala okhala ndi lipoic acid amalimbikitsa zotsatira za hypoglycemic zomwe zimachitika posakhalitsa insulin, chifukwa chake ndikofunikira kusintha mlingo wa insulin panthawi ya chithandizo.

Mankhwala sayenera kumwa:

ana ochepera zaka 16
yoyamwitsa,
pa mimba
ndi tsankho la munthu payekha kapena chizolowezi chake chosagwirizana.

Kukonzekera komwe kumakhala ndi michere kuyenera kuphatikizidwa ndi kugwiritsa ntchito mankhwala omwe amakhala ndi ayoni zitsulo - izi zimapangitsa kuti mankhwalawo azigwira bwino ntchito.

Matenda a shuga

Sikuti shuga wambiri payekha amakhala wowopsa pa thanzi, koma kuti kulumikizana ndi mapuloteni amthupi, glucose amasintha katundu wawo, kusokoneza magwiridwe antchito amthupi ambiri. Maselo am'mitsempha ndi mitsempha yamagazi amakhudzidwa makamaka. Kuphwanya magazi ndikupatsirana kwamanjenje kumayambitsa zovuta zomwe nthawi zambiri zimayambitsa kulumala.

Matenda a shuga a polyneuropathy

Vutoli limakhudza pafupifupi gawo limodzi mwa magawo atatu a odwala matenda ashuga. Imadziwonekera mu mawonekedwe akuwotcha malekezero, kulumikizana ndi ululu, paresthesia (dzanzi, kumva kwa "goosebumps") komanso kusokonezeka kwamphamvu. Pazonse, pali magawo atatu a chitukuko cha matenda ashuga polyneuropathy, kuchokera kwa subclinical, kusintha kungapezeke kokha mu labotale, kupita ku zovuta zovuta.

Kafukufuku wochitika ndi asayansi aku Romania motsogozedwa ndi Pulofesa George Negrişanu adawonetsa kuti miyezi itatu itatha kumwa alpha-lipoic acid mu 76.9% ya odwala, kuopsa kwa matendawa chifukwa cha gawo limodzi.

Mlingo woyenera kwambiri ndi 600 mg patsiku, pomwe zizindikiro zoyambira zimasintha pambuyo pa masabata 5 ogwiritsa ntchito mankhwalawa.

Gulu lina la ofufuza aku Bosnia lidapezanso kuti pambuyo pa miyezi 5 yogwiritsa ntchito alpha-lipoic acid:

Kuwonetsedwa kwa paresthesias kutsika ndi 1040%,
Kulephera kuyenda kumachepa ndi 20-30%

Kukula kwa kusinthako kudalira momwe wodwalayo amayang'anira bwino shuga. Gululi lomwe lili ndi chiwongolero chabwino kwambiri cha glycemic, zotsatira zabwino za alpha lipoic acid zinali zamphamvu.

"Malinga ndi zotsatira za kafukufuku wamankhwala atatenga lipoic acid mu 76.9% ya odwala, kuopsa kwa matenda ashuga a polyneuropathy osachepera gawo limodzi"

Mankhwala okhala ndi alpha-lipoic acid amalimbikitsidwa ndi madokotala akunja komanso apakhomo pochiza matenda ashuga a polyneuropathy. Pa mlingo wa 600 mg patsiku, mankhwalawa amaloledwa ngakhale kwa zaka 4 akugwiritsidwanso ntchito, kwinaku akuchepetsa kukula kwa matenda odwala omwe ali ndi matenda oyamba a matenda.

Mwa amuna, kukanika kwa erectile nthawi zambiri kumakhala chizindikiro choyamba cha polyneuropathy mu shuga mellitus. Alpha lipoic acid imayendetsa bwino ntchito zogonana, ndipo zotulukapo zake zimafanana ndi zotsatira za testosterone.

Diabetesic Autonomic Neuropathy

Autonomic mantha system imayang'anira ntchito ya mtima, mitsempha yamagazi, ndi ziwalo zina zamkati. Kugonjetsedwa kwa ma neuroni ochulukirapo a glucose kumakhudza, kumayambitsa matenda ashuga ozungulira bongo. Zimawonetsedwa ndikuphwanya ntchito yamtima wam'matumbo, thirakiti la m'mimba, chikhodzodzo, etc.

Alpha-lipoic acid amachepetsa kuopsa kwa matenda ashuga othana ndi matenda a shuga, kuphatikiza kusintha kwa mtima.

Zovuta za mtima

Chimodzi mwazinthu zosasangalatsa za kupsinjika kwa oxidative ndikuwonongeka kwa makoma amkati amitsempha yamagazi. Izi, mbali imodzi, zimathandizira mapangidwe a thrombus, kusokoneza kayendedwe ka magazi m'mitsempha yaying'ono (microcirculation), kumbali ina, kumawapangitsa kukhala pachiwopsezo cha atherosclerosis.

Ichi ndichifukwa chake anthu omwe ali ndi matenda ashuga nthawi zambiri amakhala ndi vuto la mtima komanso stroko. Alpha lipoic acid amalimbana ndi zovuta zingapo za matenda ashuga a mtima

Amawongolera mkhalidwe wamkati wamkati wamitsempha yamagazi,
Matenda amasinthasintha magazi,
Zimawonjezera kuyankha kwamthupi kwa ma vasodilators,
Mtima umagwira ntchito, kupewa matenda ashuga a mtima.

Matenda a shuga

Zosefera mkodzo wa impso, ma nephrons, ndi ziwiya zopindika, zomwe, monga momwe tafotokozera mgawo lapitalo, sizilekerera shuga wambiri. Chifukwa chake, ndi matenda a shuga, kupweteka kwambiri kwa impso kumayamba - matenda a shuga.

Monga momwe asayansi akuwonera, alpha lipoic acid imalepheretsa chitukuko cha matenda ashuga:

Imachepetsa kufa kwa ma podocytes - maselo ozungulira ma nephrons ndipo samadutsa mapuloteni mumkodzo,
Imachepetsa kukulitsa kwa impso, chikhalidwe cha matenda oyamba a matenda a shuga,
Imaletsa mapangidwe a glomerulossteosis - m'malo mwa ma cell of nephron omwe ali ndi minofu yolumikizana,
Wein albinuria - mawonekedwe a mapuloteni mumkodzo,
Zimalepheretsa kukula kwa masanjidwe am'maso - mawonekedwe a minyewa yolumikizana yomwe ili pakati pa glomeruli la impso. Mukamakulirakulira kwamaso am'maso, ndimawonongeka kwambiri impso.

Matenda a shuga ndi matenda oopsa, makamaka owopsa chifukwa cha zovuta zake. Alpha lipoic acid imatha kuletsa kukula kwa matenda ashuga amtundu wa 2. Zimawonjezera kukhudzika kwa minofu ku insulin ndikutsitsa shuga. Kuphatikiza apo, thioctic acid imalepheretsa kukula kwa zovuta za matendawa ku mantha, mtima ndi impso.

Mfundo yogwira ntchito

Matenda a shuga amapezeka pambuyo pa kuwonongeka kwa kapangidwe ka khungu la B. Nthawi yomweyo, mulingo wa pH umasuntha, mitsempha yamagazi imawonongeka, neuropathy imapangidwa. Kuti muchepetse njira zomwe zili pamwambazi, ndikulimbikitsidwa kuti mumwe mankhwala okamwa a acidic.

Mankhwalawa adalandila ndemanga zabwino kuchokera kwa odwala ndi madotolo ambiri, popeza atavomerezedwa:

Kuchulukitsa chitetezo chamthupi.
Anachepetsa insulin.

Ngati mankhwala a lipoic acid amupangira mtundu wachiwiri wa matenda ashuga, mungamwe bwanji mankhwalawa? Espa-lipon, Lipamide, Tiolepta, Tiogamm ndi mankhwala ena omwe ali ndi antioxidant wa thioctic amapatsidwa odwala.

Ma neurolypone omwe amayesedwa pachipatala amawonedwa kuti ndi othandiza kwambiri polimbana ndi matenda ashuga amitundu iwiri yoyambayo. Mankhwalawa amalekeredwa mosavuta komanso moyenera ndi odwala amisinkhu yosiyanasiyana. Zotsatira zoyipa zomwe zimawonedwa pa kafukufukuzi sizinakhudze thanzi la odwala. Nthawi yomweyo, madokotala sanawululire kuwonongeka kulikonse mwa ma labotale. Mankhwala Neyrolipon amagwiritsidwa ntchito pa zovuta kuthandizira neuropathy. Mankhwalawa amachitika molingana ndi chiwembu china. M'mbuyomu, adokotala amawona mawonekedwe a mankhwalawa - mapiritsi, mapiritsi, zothetsera.

Popewa, mankhwala a mitundu iwiri yoyambirira ndi omwe amapatsidwa. Amatengedwa katatu kapena nthawi imodzi patsiku. Zimatengera mlingo wa mankhwalawo. Therapy imathandizira kupewa kukula kwa zovuta za matenda ashuga achiwiri. Kuti mankhwalawa akhale othandiza, mankhwalawa amatengedwa pamimba yopanda kanthu. Kuti muchepetse mawonetseredwe a matenda am'mimba a shuga, mankhwalawa amaperekedwa kudzera m'mitsempha.

Njira yothetsera vutoli imathandizira kuchepetsa kupsinjika kwa oxidative. Mitsempha yomwe ikukhudzidwa ndi kupitilira kwa matendawa imabwezeretseka pang'onopang'ono, ndipo njira yochititsanso kukonzanso imathandizira. Kuti matenda asinthidwe mwachangu komanso mokwanira, mankhwalawa amathandizidwa ndi zakudya zama carb ochepa.

Zotsatira zoyipa zimatha kudziwonetsa pokhapokha ngati mankhwala osokoneza bongo apezeka!

Zovuta zamankhwala

Ngakhale mukumwa mankhwala osokoneza bongo a thioctic acid, mavuto ena amatha kuwoneka, kuphatikizapo migraine, kufooka, ndi matenda a dyspeptic. Chipatala chofananacho chimawonedwa pambuyo pa kuchuluka kwa mankhwala.

Anthu ambiri odwala matenda ashuga amayesa kuchotsa matendawa potenga antioxidant iyi.

Koma kukwaniritsa zoterezi ndizosatheka. Izi zikufotokozedwa ndikuti asidi sadziunjikira, koma amangopereka chithandizo chanthawi yochepa. Mankhwala aliwonse omwe ali ndi lipoic acid amalimbikitsidwa kuti aphatikizidwe ndi zovuta zochizira matenda amtundu 1 komanso matenda a shuga. Mothandizidwa ndi nyimbo zoterezi, zovuta zoyipa za thupi la wodwala zimachepetsedwa.

Mankhwala omwe ali pamwambapa, madokotala amaphatikizapo:

Mtengo wokwera.
Kupezeka kwa nsomba kapena kutulutsidwa kwa zinthu zotsika mtengo.

Mankhwala omwe amayesedwa pachipatala amaloledwa bwino ndi odwala matenda ashuga popanda kuyambitsa mavuto. Nthawi zina odwala amatha kudandaula za mseru, kusanza, kufooka wamba. Ngati chipatala choterechi chikukula, ndikulimbikitsidwa kuti mufunsane ndi endocrinologist.

Zaka ziwiri zapitazo adandipeza ndi matenda a shuga 1. A endocrinologist adalangiza kuti amwe mankhwala osokoneza bongo a lipoic acid. Ndinkamwa mapiritsiwo kwa mwezi wathunthu, zotsatira zake zinali, koma osati zazikulu. Kenako ndinapatsidwa Espa Lipon. Adandithandiza.

Alexandra, wazaka 29:

Adatenga lipoic acid, chifukwa panali zokayikitsa za matenda a shuga. Nthawi yomweyo, adotolo adalangiza kuti azitsatira zakudya. Chithandizo chokwanira chathandiza.

Ndine wodwala matenda ashuga. Ndili ndi mantha kuti sipakhala zovuta, chifukwa ndimatsatira malangizo onse a dokotala. Adandipangira neuroleepone. Amandichotsera kutopa ndi kufooka kwanga.

Udindo wa lipoic acid mthupi

Lipoic kapena thioctic acid amagwiritsidwa ntchito kwambiri pamankhwala. Mankhwala ozikidwa pa mankhwalawa amagwiritsidwa ntchito kwambiri pochiza matenda amtundu wa 2 komanso matenda a shuga. Komanso, mankhwalawa amagwiritsidwa ntchito popanga zovuta za matenda a chitetezo cha m'thupi komanso matenda am'mimba.

Lipoic acid adasiyanitsidwa koyamba ndi chiwindi cha ng'ombe mu 1950. Madotolo awona kuti phula ili limathandizira pakuchitika kwa mapuloteni m'thupi.

Chifukwa chiyani a lepic acid amagwiritsidwa ntchito ngati matenda a shuga a 2? Izi ndichifukwa choti thunthu limakhala ndi zinthu zingapo zothandiza:

Lipoic acid amathandizira pakuphulika kwa mamolekyulu a shuga. Zakudyazi zimakhudzidwanso pantchito ya ATP mphamvu synthesis.
Mankhwala ndi antioxidant wamphamvu. Pogwira ntchito yake, siyotsika ndi vitamini C, tocopherol acetate ndi mafuta a nsomba.
Thioctic acid amathandizira kulimbikitsa chitetezo chokwanira.
Nutrient ali ndi katundu wotchedwa insulin. Zinapezeka kuti chinthucho chimathandizira kuwonjezeka kwa zochitika zamkati zamatumbo a glucose mu cytoplasm. Izi zimakhudza njira yogwiritsira ntchito shuga mu minofu. Ichi ndichifukwa chake lipoic acid imaphatikizidwa ndi mankhwala ambiri amtundu wa 1 komanso matenda a shuga 2.
Thioctic acid imawonjezera kukana kwa thupi chifukwa cha ma virus ambiri.
Nutrient imabwezeretsa antioxidants amkati, kuphatikizapo glutatitone, tocopherol acetate ndi ascorbic acid.
Lipoic acid amachepetsa mavuto omwe amayambitsidwa ndi poizoni pama cell cell.
Nutrient ndi sorbent yamphamvu.Zatsimikiziridwa mwasayansi kuti chinthucho chimamangiriza poizoni ndi magulu awiri azitsulo zolemera muzitsulo za chelate.

Mkuyesa kambiri, zidapezeka kuti alpha lipoic acid imakulitsa chidwi cha maselo kuti apange insulin. Izi ndizofunikira makamaka kwa matenda ashuga amtundu 1. Thupi limathandizanso kuchepetsa thupi.

Izi zidatsimikiziridwa mwasayansi mu 2003. Asayansi ambiri amakhulupirira kuti lipoic acid imatha kugwiritsidwa ntchito pa matenda ashuga, omwe amayenda ndi kunenepa kwambiri.

Kukonzekera kwa Lipoic Acid

Ndi mankhwala ati omwe amaphatikiza lipoic acid? Izi ndi gawo la mankhwala monga Berlition, Lipamide, Neuroleptone, Thiolipone. Mtengo wa mankhwalawa sapitilira 650-700 oyendetsa. Mutha kugwiritsa ntchito mapiritsi okhala ndi lipoic acid a matenda ashuga, koma zisanachitike muyenera kufunsa dokotala.

Izi ndichifukwa choti munthu amene amamwa mankhwalawa angafunikire insulini yochepa. Zomwe zili pamwambapa zili ndi 300 mpaka 600 mg ya thioctic acid.

Kodi mankhwalawa amagwira ntchito bwanji? Awa mankhwala ndi ofanana. Mankhwala ali ndi tanthauzo loteteza maselo. Zinthu zomwe zimagwiritsidwa ntchito ndi mankhwalawa zimateteza ma membala am'mimba ku zotsatira za magwiridwe anthawi.

Zisonyezero zamagwiritsidwe ntchito a mankhwala ozikidwa pa lipoic acid ndi:

Mellitus wosadalira insulin (mtundu wachiwiri).
Insulin-wodwala matenda a shuga a mellitus (mtundu woyamba).
Pancreatitis
Matenda a chiwindi.
Matenda a shuga a polyneuropathy.
Kuwonongeka kwamafuta kwa chiwindi.
Coronary atherosulinosis.
Kulephera kwa chiwindi.

Berlition, Lipamide ndi mankhwala ochokera ku gawo ili amathandizira kuchepetsa thupi. Ndiye chifukwa chake mankhwalawa amatha kugwiritsidwa ntchito pochiza matenda amtundu wa 2 shuga, omwe amayamba chifukwa cha kunenepa kwambiri. Mankhwala amaloledwa kumwa panthawi yodyera kwambiri, monga kuchepetsa kuchepa kwa calorie okwana ma kilocalories 1000 patsiku.

Kodi ndingatenge bwanji alpha lipoic acid a matenda ashuga? Mlingo watsiku ndi tsiku ndi 300-600 mg. Mukamasankha mlingo, ndikofunikira kuganizira zaka za odwala komanso mtundu wa matenda ashuga. Ngati mankhwala omwe ali ndi lipoic acid amagwiritsidwa ntchito pochiza kunenepa kwambiri, mlingo wa tsiku ndi tsiku umachepetsedwa mpaka 100-200 mg. Kutalika kwa mankhwalawa nthawi zambiri mwezi umodzi.

Zotsatira zosagwiritsidwa ntchito ndi mankhwalawa:

Nthawi yonyamula.
Thupi lawo ndi thioctic acid.
Mimba
Zaka za ana (mpaka zaka 16).

Ndizofunikira kudziwa kuti mankhwalawa amathandizira kudziwa zambiri za insulin. Izi zikutanthauza kuti nthawi yamankhwala, mulingo wa insulin uyenera kusinthidwa.

Berlition ndi mawonekedwe ake sizikulimbikitsidwa kuti atengedwe limodzi ndi kukonzekera komwe kumakhala ndi zitsulo zazitsulo. Kupanda kutero, mphamvu ya mankhwalawo itha kuchepetsedwa.

Mukamagwiritsa ntchito mankhwala a lipoic acid, zotsatira zoyipa monga:

Kutsegula m'mimba
Kupweteka kwam'mimba.
Mseru kapena kusanza.
Minofu kukokana.
Kuchulukitsa kwachulukira.
Hypoglycemia. Woopsa, matenda a shuga amayamba. Zikachitika, wodwalayo ayenera kupatsidwa thandizo mwachangu. Ndikulimbikitsidwa kugwiritsa ntchito njira ya shuga kapena kuwaza ndi shuga.
Mutu.
Diplopia
Spot zotupa.

Ngati mankhwala osokoneza bongo, thupi lawo siligwirizana angayambe, mpaka anaphylactic mantha. Pankhaniyi, ndikofunikira kutsuka m'mimba ndikumwa antihistamine.

Ndipo ndemanga zanji za mankhwalawa? Ogula ambiri amati lipoic acid imagwira ntchito m'matenda a shuga. Mankhwala omwe amapanga mankhwalawa athandiza kuyimitsa zizindikiro za matendawa. Anthu amanenanso kuti kugwiritsa ntchito mankhwalawa kumawonjezera nyonga.

Madokotala amathandizira Berlition, Lipamide ndi mankhwala ofananawo m'njira zosiyanasiyana. Ambiri a endocrinologists amakhulupirira kuti kugwiritsa ntchito lipoic acid kulungamitsidwa, chifukwa mankhwalawo amathandizira kuti magwiritsidwe ntchito a glucose agwire.

Koma madotolo ena ali ndi lingaliro kuti mankhwala ozikidwa pa chinthuchi ndi mtundu wamba.

Lipoic acid wamitsempha

Neuropathy ndi njira yomwe magwiridwe antchito amanjenje amasokonekera. Nthawi zambiri, matendawa amakula ndi matenda amtundu wa 2 komanso matenda a shuga. Madokotala amati ichi ndi chakuti matenda ashuga amasokoneza kayendedwe ka magazi ndikuwonjezera kuyipa kwa mitsempha.

Ndi minyewa ya m'magazi, munthu amayamba kumva kutupikana miyendo, mutu ndi kugwedezeka kwa dzanja. Kafukufuku wambiri wazachipatala adawulula kuti pakupitilira kwa zamatsenga zamtunduwu, ma radicals aulere amathandiza kwambiri.

Ichi ndichifukwa chake anthu ambiri omwe ali ndi vuto la matenda ashuga amawerengedwa kuti ndi acidic. Katunduyu amathandizira kukhazikika kwamanjenje, chifukwa chakuti ndi antioxidant wamphamvu. Komanso, mankhwala ozikidwa pa thioctic acid amathandizira kukonza zomwe zimayambitsa mitsempha.

Ngati munthu wadwala matenda a shuga, ndiye kuti ayenera:

Idyani zakudya zomwe zimakhala ndi lipoic acid.
Imwani mavitamini osakanikirana ndi mankhwala antidiabetes. Berlition ndi Tiolipon ndi angwiro.
Nthawi ndi nthawi, thioctic acid imathandizidwa kudzera mu minyewa (izi ziyenera kuchitika moyang'aniridwa ndi achipatala).

Kuchiza panthawi yake kumatha kuchepetsa mwayi wopita patsogolo kwa kudziyimira kwamitsempha yamagazi (matenda oyenda ndi matenda a mtima). Matendawa ndi amodzi mwa odwala matenda ashuga. Kanemayo munkhaniyi akupitiliza mutu wakugwiritsira ntchito asidi mu shuga.

Kumwa mankhwala

Mu shuga mellitus, alphalipoic acid akhoza kutchulidwa ngati prophylactic mu piritsi. Ndizothekanso kukoka mtsempha, koma uyenera kusungunuka kaye ndi mchere. Mwachizolowezi, mlingo ndi 600 mg patsiku wogwiritsidwa ntchito kunja, ndi 1200 mg wa mankhwala othandizira odwala, makamaka ngati wodwalayo akhudzidwa kwambiri ndi mawonekedwe a matenda ashuga a polyneuropathy.

Osavomerezeka pambuyo chakudya. Ndikwabwino kumwa mapiritsi pamimba yopanda kanthu. Ndikofunika kulingalira kuti zochitika zapamwamba za bongo sizimamveka bwino, pomwe mankhwalawa ali ndi zovuta zochepa zoyipa ndi zotsutsana.