Kufotokozera ndi malangizo ogwiritsira ntchito mankhwala Berlition

Berlition akupezeka mu mitundu yotsatsira iyi:

• Tsimikizirani yankho la kulowetsedwa: greenish-chikasu, mandala (Berlition 300: 12 ml mu ampoules wamdima wamdima, 5, 10 kapena 20 ampoules mumakatoni makatoni, 1 tray mu paketi ya makatoni, Berlition 600: 24 ml mu magalasi amdima amdima, ma ampoules 5 m'matumba apulasitiki, pallet 1 pamakatoni
• Mapiritsi okhala ndi filimu: ozungulira, biconvex, kumbali imodzi - chiwopsezo, chikaso cha utoto, pamtanda pali mawonekedwe osawoneka bwino (ma PC 10. M'matumba, matuza 3,6.10 m'bokosi lamatoni).

Chofunikira chachikulu ndi thioctic acid:

• Mu 1 ampoule ofunikira - 300 mg kapena 600 mg,
• Piritsi limodzi - 300 mg.

Mankhwala

Thioctic (alpha-lipoic) acid ndi antioxantant wam'mbuyomu wa mwachindunji (womangika mosasintha) komanso osachita kanthu. Ndilo gulu la coenzymes omwe akukhudzidwa ndi decarboxylation ya alpha-keto acids. Kapangidwe kameneka kamathandizira kutsitsa shuga wa plasma ndikuwonjezera kuchuluka kwa chiwopsezo cha glycogen, kumachepetsa kukana kwa insulini, kumathandizanso pakuyambitsa matenda a lipid ndi carbohydrate, komanso kumathandizira kagayidwe ka cholesterol.

Popeza thioctic acid imakhala ndi antioxidant katundu, imateteza maselo kuti asawonongedwe ndi zinthu zomwe zaswedwa, imalepheretsa kupanga kwa mapangidwe opanga glycosylation omwe amapita patsogolo m'mapuloteni m'maselo amitsempha, omwe amaphatikizidwa ndi matenda a shuga, amawongolera kuthamanga kwa magazi ndi kuchepa kwa magazi, ndikuwonjezera kuchuluka kwa thupi kwa glutathione antioxidant. Kupereka kuchepa kwa glucose wamagazi m'magazi am'magazi, gawo lodziwika bwino la Berlition limakhudza njira ina ya glucose metabolism ya shuga mellitus, imachepetsa kudzikundikira kwa metabolic metabolites mwa mawonekedwe a ma polols ndipo, chifukwa chake, amachepetsa edema yamitsempha yamanjenje.

Thioctic acid imakhudzidwa kagayidwe ka mafuta, kamene kamayambitsa kuchuluka kwa phospholipids, makamaka phosphoinositides, zomwe zimapangitsa kuti mawonekedwe a mawonekedwe owonongeka a cell membrane. Komanso, chinthucho chimakongoletsa kuphatikizika kwa mitsempha ndikutulutsa mphamvu, zimakupatsani mwayi wochotsa zovuta zakumwa za metabolites (pyruvic acid, acetaldehyde). Thioctic acid imalepheretsa mapangidwe ochulukirapo a mamolekyulu a okosijeni a okosijeni aulere, amachepetsa ischemia ndi endoneural hypoxia, akumachepetsa zizindikiro za polyneuropathy, zomwe zimafotokozedwa ndikumverera kadzuwa, kupweteka kapena kutentha m'miyendo, komanso paresthesias. Chifukwa chake, chinthuchi chimasintha metabolism ya lipid ndipo chimadziwika ndi neurotrophic ndi antioxidant. Kugwiritsidwa ntchito kwa thioctic acid mu mawonekedwe a mchere wa ethylene diamine kumayambitsa kuchepa kwa zovuta za zotsatira zoyipa.

Pharmacokinetics

Mothandizidwa ndi mtsempha wa magazi wa Berlition, kuchuluka kwa mafuta omwe amapezeka m'madzi a m'magazi pafupifupi 20 μg / ml pakatha mphindi 30 kulowetsedwa, ndipo malo omwe ali munthawi yopondera ndi pafupifupi 5 μg / h / ml. Thioctic acid imakhala ndi "gawo loyamba" kudzera mu chiwindi. Ma metabolites ake amapangidwa chifukwa cha kuphatikizika ndi oxidation kwa tcheni cham'mbali. Kuchuluka kwa magawidwe ndi pafupifupi 450 ml / kg. Chilolezo chonse cha plasma ndi 10-15 ml / min / kg. Thioctic acid imachotsedwa kudzera mu impso (80-90%), makamaka mwa ma metabolites. Hafu ya moyo ili pafupifupi mphindi 25.

Malangizo ogwiritsira ntchito Berlition: njira ndi mlingo

Mankhwala nthawi zambiri amatengedwa kamodzi patsiku, m'mawa, theka la ola musanadye kadzutsa. Mapiritsi a Berlition sangathe kutafunidwa ndikuphwanyidwa. Mlingo wa tsiku ndi tsiku wa akulu ndi 600 mg (mapiritsi 2).

Mankhwala mu mawonekedwe a zimakhazikika, kuchepetsedwa ndi 0,9% sodium kolorayidi njira, chikuyendetsedwera 250 mg kwa theka la ora. Mlingo watsiku ndi tsiku kwa odwala akuluakulu ndi 300-600 mg. Kukhazikitsidwa kwa Berlition kudzera m'mitsempha nthawi zambiri kumatha masabata awiri, pambuyo pake wodwalayo amapatsidwa mankhwala pakamwa.

Malangizo apadera

Panthawi yamankhwala, muyenera kusiya kumwa zakumwa zoledzeretsa, popeza Mowa amachepetsa mphamvu ya asidi.

Odwala omwe ali ndi matenda ashuga ayenera kuyang'anitsitsa kuchuluka kwa shuga m'magazi awo.

Idyani zakudya zamkaka, komanso kutenga magnesium ndi kukonzekera kwachitsulo panthawi yamankhwala muyenera kukhala masana.

Ndi kuphatikiza kwa mankhwalawa kwa mankhwala amkamwa ndi hypoglycemic wothandizila ndi insulin, zotsatira zake zomaliza zimalimbikitsidwa.

Kukopa pa kuthekera koyendetsa magalimoto ndi njira zowerengeka

Kafukufuku wazotsatira za Berlition pa kuthamanga kwa zochitika zama psychomotor ndi kuthekera kuzindikira ndikuwunika mwachangu zinthu zosazolowereka sizinachitike, chifukwa chake, munthawi ya chithandizo ndi mankhwalawa, chisamaliro chapadera chiyenera kuchitika mukamayendetsa ndikumagwira ntchito zoopsa zomwe zimafunikira chidwi chochulukirapo komanso chisamaliro.

Kuyanjana kwa mankhwala osokoneza bongo

Popeza kupangidwa kwa chelate complexes a thioctic acid ndi zitsulo ndizotheka, Berlition siyenera kuyikidwa limodzi ndi kukonzekera kwachitsulo. Kuphatikiza kwa mankhwalawa ndi chisplatin kumachepetsa mphamvu yotsiriza.

Thioctic acid imaphatikizana ndi mamolekyulu a shuga, ndikupanga zinthu zovuta zomwe zimatha kusungunuka. Berlition ndi yoletsedwa kugwiritsidwa ntchito motsutsana ndi maziko a mankhwalawa ndi njira ya Ringer, dextrose, fructose ndi glucose, komanso njira zomwe zimagwirizanirana ndi disulfide ndi SH-magulu. Mankhwala timapitiriza hypoglycemic zotsatira za insulin ndi ena hypoglycemic mankhwala ntchito munthawi yomweyo. Ethanol amachepetsa mphamvu ya achire ya Berlition.

Zofanana muzolemba za Berlition ndi Espa-Lipon, Oktolipen, Thiogamma, Lipothioxon, Thiolipon ndi Neuroleepone.

Ndemanga za Berlition

Malinga ndi ndemanga, Berlition 300 ndi Berlition 600 mu mtundu uliwonse wa mapiritsi (mapiritsi, jekeseni) amagwiritsidwa ntchito pochiza odwala matenda a shuga ndi matenda a chiwindi. Komanso, mankhwalawa amawonedwa ngati othandiza kwambiri osati pakati pa odwala, komanso m'magulu azachipatala. Mu 95% ya milandu, chithandizo ndi Berlition chimapereka zotsatira zabwino, ndipo zoyipa sizimapezeka. Koma ziyenera kukumbukiridwa kuti katswiri yekha yemwe ayenera kupereka mankhwala ndikupanga mtundu wa mankhwala.

Contraindication

Malinga ndi malangizo, Berlition ndi yotsutsana:

• Kusalolera payekha kwa alpha lipoic acid kapena zigawo zothandizira za mankhwala,
• Osakwana zaka 18
• Mimba komanso kuyamwa,

Mapiritsi 300 a Oral 300 amaphatikizidwa pochiza odwala omwe ali ndi malabsorption a glucose-galactose, kusowa kwa lactase ndi galactosemia. Makapisozi a Berlition samawonetsedwa kwa odwala omwe ali ndi tsankho la fructose.

Pogwiritsa ntchito Berlition, muyenera kusamala ndi matenda ashuga. Ngati pakufunika kugwiritsa ntchito mankhwalawa pagulu la odwala, glycemia iyenera kuyang'aniridwa pafupipafupi.

Mlingo ndi makonzedwe

Kuphatikizika kwa mapiritsi ndi makapisozi kumayikidwa mkati. Mankhwalawa saloledwa kutafuna kapena kupera pogwiritsira ntchito. Mlingo wa tsiku ndi tsiku umatengedwa kamodzi patsiku, pafupifupi theka la ola musanadye chakudya cham'mawa. Kuti mukwaniritse chithandizo chokwanira kwambiri, ndikofunikira kuti mutsatire malamulo ovomerezeka osankhidwa mu malangizo a Berlition.

Monga lamulo, kutalika kwa mankhwala ndi Berlition ndikutali. Nthawi yeniyeni yovomerezeka imatsimikiziridwa payekha ndi dokotala wopita. Mlingo wa mankhwalawa:

• Ndi matenda ashuga polyneuropathy - 600 mg patsiku,
• Ndi matenda a chiwindi - 600-1200 mg wa thioctic acid patsiku.

Woopsa milandu, Ndi bwino kupatsa wodwalayo Berlition mu njira yothetsera kulowetsedwa.

Berlition mu mawonekedwe a kutsata pokonza njira yothetsera kulowetsedwa imagwiritsidwa ntchito kudzera mu mtsempha wamitsempha. Monga zosungunulira, 0,9% sodium kolorayidi yoyenera kugwiritsidwa ntchito, 250 ml ya njira yokonzedwayo imaperekedwa kwa theka la ola. Mlingo wa mankhwalawa:

• Ndi mtundu waukulu wa matenda ashuga polyneuropathy - 300-600 mg wa Berlition,
• Woopsa matenda a chiwindi - 600-1200 mg wa thioctic acid patsiku.

Mitundu ya Parenteral yamankhwala imapangidwira chithandizo, nthawi yake ndi 0.5-1 mwezi, pambuyo pake, monga lamulo, wodwalayo amapatsidwa mapiritsi kapena makapisozi a Berlition.

Zotsatira zoyipa

Kugwiritsa ntchito Berlition kungayambitse zotsatirazi:

• Matumbo: Kusanza ndi mseru, kudzimbidwa kapena kutsegula m'mimba, kusintha kwa kakomedwe, Zizindikiro zakuthwa,
• Njira zotumphukira ndi zamkati zamanjenje: pambuyo poti jekeseni wofulumira m'mitsempha, kugwidwa, kumva kuwawa m'mutu, diplopia,
• Mtima dongosolo: Hyperemia ya nkhope ndi chapamwamba thupi, tachycardia, kumverera kwamphamvu ndi kupweteka pachifuwa,
• Chifuwa: zotupa pakhungu, kuyabwa, chikanga, urticaria.

Nthawi zina, ndi mtsempha wa magazi wokwanira Mlingo wa mankhwalawa, mantha a anaphylactic amatha. Komanso kukula kwa mutu, chizungulire, kuwonongeka kwa mawonekedwe, kupuma movutikira, purpura ndi thrombocytopenia sikuwonetsedwa.

Odwala ndi polyneuropathy kumayambiriro kwa mankhwala ndi Berlition, kuwonjezereka kwaresthesia ndikotheka, limodzi ndi kumverera kwa "tsekwe".

Migwirizano ndi magwiritsidwe akusungidwa

Malinga ndi malangizo, Berlition iyenera kusungidwa m'malo owuma, amdima komanso ozizira.

The kuganizira kwambiri yankho la kulowetsedwa ali alumali moyo 3 zaka. Mu fomu yomalizidwa, yankho la kulowetsedwa silingathe kusungidwa kwa maola opitilira 6 (bola botolo likatetezedwa ku dzuwa).

Mapiritsi a Berlition 300 Oral ali ndi alumali moyo wazaka 2, ma Berlition 300 makapisozi - zaka 3, Berlition zaka 600 - 2,5.

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