Siofor 1000: malangizo a mapiritsi a shuga

Siofor 1000: malangizo ogwiritsa ntchito ndi kuwunikira

Dzina lachi Latin: Siofor 1000

Code ya ATX: A.10.B.A.02

Chothandizira: Metformin (Metformin)

Wopanga: BERLIN-CHEMIE, AG (Germany), DRAGENOPHARM APOTHEKER PUSCHL, GmbH & Co KG (Germany)

Kusintha kwamalingaliro ndi chithunzi: 10.24.2018

Mitengo muma pharmacies: kuchokera ku 383 ma ruble.

Siofor 1000 ndi mankhwala osokoneza bongo a hypoglycemic.

Kutulutsa mawonekedwe ndi kapangidwe kake

Mlingo wa Siofor 1000 - mapiritsi okhala ndi mbali: yoyera, yofupika, yokhala ndi notch imodzi ndi zojambula zooneka ngati "snap-tab" mbali inayi (m'matumba a ma 15 ma PC., Pamatayala okhala ndi matuza a 2, 4 kapena 8).

Piritsi 1:

• yogwira mankhwala: metformin hydrochloride - 1 g,
• othandizira zigawo: magnesium stearate - 0,005 8 g, povidone - 0,053 g, hypromellose - 0,035 2 g,
• chipolopolo: titanium dioxide (E 171) - 0,009 2 g, macrogol 6000 - 0,002 3 g, hypromellose - 0,011 5 g.

Mankhwala

Metformin, chinthu chomwe chimagwiritsidwa ntchito ngati mankhwalawo, ndi cha gulu la Biguanides.

Zochita za Siofor 1000, chifukwa cha metformin:

• ali ndi antihyperglycemic effect,
• Amapereka kuchepa kwa masamba a shuga ndi postprandial plasma,
• simalimbikitsa insulin katemera, chifukwa chake siyambitsa hypoglycemia,
• amachepetsa kupanga kwa shuga m'chiwindi poletsa glycogenolysis ndi gluconeogeneis,
• zimawonjezera kukhudzika kwa minofu kupita ku insulin, yomwe imapangitsa kuti magwiritsidwe ntchito azikhala bwino komanso kuti mafuta a shuga azikhala mosavuta.
• amalepheretsa mayamwidwe a shuga m'matumbo,
• imapangitsa kaphatikizidwe ka glycogen mu intracellular kudzera mu glycogen synthetase,
• kumawonjezera kuthekera kwamapuloteni onse a shuga a michere,
• bwino zimakhudza kagayidwe kachakudya matenda a m'magazi, amachepetsa kuchuluka kwa cholesterol, triglycerides ndi kachulukidwe kochepa cholesterol.

Pharmacokinetics

• mayamwidwe: pambuyo m`kamwa makonzedwe amachokera ku m'mimba thirakiti, C_max (pazambiri plasma ndende) zimatheka pambuyo maola 2,5 ndipo mukamamwa mlingo wambiri sizidutsa 4 μg pa 1 ml. Mukamadya, kunyowa kumatsika ndikuchepera.
• kufalitsa: amadziunjikira impso, chiwindi, minofu, ma cell a salivary, kulowa m'magazi ofiira a m'magazi. Mtheradi wa bioavailability mwa odwala athanzi amasiyana kuchokera pa 50 mpaka 60%. Sizikugwirizana ndi mapuloteni amadzi a m'magazi, V_d (pafupifupi voliyumu yogawa) - 63-276 l,
• chofufumitsa: chosasinthika chomwe chimaperekedwa ndi impso, chilolezo cha impso - choposa 400 ml 1 min. T_1/2 (kuchotsa hafu ya moyo) - pafupifupi maola 6.5. Kutulutsidwa kwa Metformin ndi kuchepa kwa impso kumatsika molingana ndi kupezeka kwa creatinine chilolezo, kuphatikiza hafu ya moyo kumatalika, ndipo kugundika kwa chinthu m'magazi a magazi kumakulanso.

Zizindikiro zogwiritsidwa ntchito

Siofor 1000 imaperekedwa kwa odwala omwe ali ndi matenda a shuga 2, makamaka onenepa kwambiri, pamene mankhwala othandizira pakudya ndi olimbitsa thupi sangachite.

Mankhwala mu ana opitirira zaka 10 amagwiritsidwa ntchito ngati monotherapy kapena osakanikirana ndi insulin, mwa akulu ngati monotherapy kapena ngati gawo limodzi la mankhwala apakamwa a hypoglycemic ndi insulin.

Zotsatira za pharmacological

Hypoglycemic mankhwala ochokera pagulu la Biguanide. Amapereka kuchepa kwa magulu oyambira a glucose oyambira komanso a postprandial. Simalimbikitsa kubisalira kwa insulin chifukwa chake sikumabweretsa hypoglycemia. Kuchita kwa metformin mwina kumatengera njira zotsatirazi: - kutsika kwa kupanga shuga mu chiwindi chifukwa cha kulepheretsa kwa gluconeogeneis ndi glycogenolysis, - kuchuluka kwa chidwi cha insulini ndipo, chifukwa chake, kusintha kwa glucose pakulowerera m'mimba. Metformin, kudzera mu zochita zake pa glycogen synthetase, imapangitsa kaphatikizidwe ka glycogen. Zimawonjezera kuthekera kwamapuloteni onse a glucose membrane onyamula mpaka pano. Mosasamala kanthu za kuchuluka kwa glucose wamagazi, imakhala ndi phindu pa metabolidi ya lipid, zomwe zimapangitsa kuchepa kwa cholesterol yonse, cholesterol yotsika komanso triglycerides.

Mikhalidwe yapadera

Musanafotokozere mankhwala, komanso miyezi isanu ndi umodzi, ndikofunikira kuwunika ntchito ya chiwindi ndi impso. Ndikofunikira kuyendetsa mulingo wa lactate m'magazi osachepera 2 pachaka. Njira ya mankhwalawa ndi Siofor® 500 ndi Siofor ® 850 iyenera kusinthidwa ndi mankhwala ena a hypoglycemic (mwachitsanzo, insulin) masiku awiri pamaso pa X-ray yokhala ndi iv. Yothandizirana ndi ayodini, komanso masiku awiri asanachitidwe opaleshoni pansi pa opaleshoni wamba, ndikupitiliza izi Mankhwala kwa masiku ena awiri pambuyo pa kuyembekezera kapena pambuyo pa opaleshoni. Kuphatikiza mankhwala ndi sulfonylureas, kuwunika mosamala kuchuluka kwa shuga m'magazi ndikofunikira. Zotsatira pa luso lotha kuyendetsa magalimoto ndi kayendedwe kazinthu Mukamagwiritsa ntchito Siofor®, sizikulimbikitsidwa kuti muzichita zinthu zomwe zimafunikira ndikuwongolera mwachangu ma psychomotor chifukwa choopsa cha hypoglycemia.

• Metformin hydrochloride 1000 mg Othandizira: povidone K25, hypromellose, magnesium stearate, macrogol 6000, titanium dioxide (E171)

Kuyanjana kwa mankhwala

Pogwiritsa ntchito munthawi yomweyo ndimomwe zimachokera ku sulfonylurea, acarbose, insulin, NSAIDs, ma inhibitors a MAO, oxetetracycline, zoletsa za ACE, clofibrate zotumphukira, cyclophosphamide, beta-blockers, ndizotheka kuwonjezera zotsatira za hypoglycemic za Siofor®. Pogwiritsa ntchito munthawi yomweyo corticosteroids, kulera kwapakamwa, epinephrine, sympathomimetics, glucagon, mahomoni a chithokomiro, zotumphukira zochokera mu mtima, zotuluka za nicotinic acid, ndizotheka kuchepetsa zotsatira za hypoglycemic za Siofor®. Siofor® imatha kufooketsa mphamvu ya anticoagulants osadziwika. Pogwiritsa ntchito munthawi yomweyo ndi Mowa, chiopsezo chokhala ndi lactic acidosis imachuluka. Kuphatikizana kwa pharmacokinetic kwa furosemide kumawonjezera Cmax ya metformin m'madzi a m'magazi. Nifedipine imawonjezera mayamwidwe, Cmax ya metformin m'madzi a m'magazi, imatulutsa chimbudzi. Kukonzekera kwa cationic (amiloride, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamteren, vancomycin

Malo osungira

• sitolo firiji 15-25 madigiri
• osayandikira ana

Zambiri zoperekedwa ndi State Register of Medicines.

• Glycomet-500, Glycon, Glyformin, Glyukofag, Metformin.

Lactic acidosis ndi vuto lalikulu la pathological lomwe limakhala losowa kwambiri, limagwirizanitsidwa ndi kuchuluka kwa lactic acid m'magazi, omwe amatha chifukwa cha kudziwitsidwa kwa metformin. Zofotokozedwa za chitukuko cha lactic acidosis mwa odwala omwe amalandira metformin amawonetsedwa makamaka mwa odwala omwe ali ndi matenda osokoneza bongo omwe amalephera kwambiri aimpso. Kupewera kwa lactic acidosis kumaphatikizapo kuzindikiritsa zinthu zonse zokhudzana ndi chiopsezo, monga matenda osokoneza bongo, ketosis, kusala kwa nthawi yayitali, kumwa kwambiri mowa, kulephera kwa chiwindi, komanso vuto lililonse lomwe lingakhale ndi hypoxia. Ngati mukukayikira kukula kwa lactic acidosis, kusiya mankhwala mwachangu ndi kuchipatala mwadzidzidzi ndikulimbikitsidwa.

Popeza metformin imachotsedwa impso, kuphatikizira kwa metabolinine m'madzi am'magazi kuyenera kutsimikiziridwa musanayambe chithandizo, komanso pafupipafupi. Kusamalidwa kwapadera kuyenera kumwedwa ngati pali chiopsezo cha matenda aimpso, mwachitsanzo, kumayambiriro kwa mankhwala omwe ali ndi antihypertensive mankhwala, diuretics kapena NSAIDs.

Kuchiza ndi Siofor ® kuyenera kusinthidwa kwakanthawi ndi mankhwala ena a hypoglycemic (mwachitsanzo, insulin) maola 48 asanafike ndi maola 48 pambuyo pa X-ray yokhala ndi iv yoyendetsedwa ndi othandizira ayodini.

Kugwiritsa ntchito mankhwalawa Siofor ® kuyenera kuyimitsidwa maola 48 asanapangidwe opaleshoni yomwe idakonzedwa pansi pa opaleshoni yayikulu, ndi msana kapena opaleshoni yam'mimba. Mankhwalawa amayenera kupitilizidwa pambuyo poti ayambanso kudya pakamwa kapena osachepera maola 48 atachitidwa opaleshoni, malinga ndi chitsimikiziro cha ntchito yachilendo.

Siofor ® sichimalo mmalo mwa zakudya komanso zolimbitsa thupi tsiku ndi tsiku - mitundu iyi ya mankhwalawa iyenera kuphatikizidwa mogwirizana ndi malingaliro a dokotala. Pa chithandizo ndi Siofor ®, odwala onse ayenera kutsatira zakudya zokhala ndi chakudya tsiku lonse. Odwala onenepa kwambiri ayenera kutsatira zakudya zamafuta ochepa.

Laboratory mayeso muyezo kwa odwala matenda a shuga mellitus ayenera kuchitika pafupipafupi.

Musanagwiritse ntchito Siofor ® ana a zaka zapakati pa 10 mpaka 18, kuwunika kwa matenda a shuga a 2 kuyenera kutsimikiziridwa.

Pakapita maphunziro azachipatala omwe adawongolera chaka chimodzi, zotsatira za metformin pakukula ndi kukula, komanso kutha kwa ana sizinawoneke, zambiri pazizindikirozi zomwe zimagwiritsidwa ntchito nthawi yayitali sizikupezeka. Pankhani imeneyi, kuwunikira mosamala magawo omwe ana akulandila metformin akulimbikitsidwa, makamaka munthawi ya prepubertal (zaka 10-12).

Monotherapy yokhala ndi Siofor ® siziwatsogolera ku hypoglycemia, koma kusamala kumalangizidwa mukamagwiritsa ntchito mankhwalawa ndi insulin kapena sulfonylurea.

Kukopa pa kuyendetsa magalimoto ndi kayendedwe kazinthu

Kugwiritsa ntchito kwa Siofor ® sikumayambitsa hypoglycemia, chifukwa chake, sikukhudza kuthekera koyendetsa magalimoto ndikusunga machitidwe.

Pogwiritsa ntchito munthawi yomweyo kugwiritsa ntchito mankhwala a Siofor ® ndi mankhwala ena a hypoglycemic (sulfonylureas, insulin, repaglinide), chitukuko cha zochitika za hypoglycemic ndizotheka, motero muyenera kusamala mukamayendetsa magalimoto ndi zochitika zina zoopsa zomwe zimafuna kuyang'aniridwa komanso kuthamanga kwa zochitika zama psychomotor.

Kuphwanya kwakukulu

Mankhwala osavomerezeka kuti mugwiritse ntchito ngati:

1. pali chidwi chachikulu ndi chinthu chachikulu chogwira (metformin hydrochloride) kapena zigawo zina za mankhwala,
2. kutengera chiwonetsero cha zizindikiro za kusokonezeka motsutsana ndi maziko a matenda ashuga. Izi zitha kukhala zowonjezereka pakuphatikizidwa kwa shuga m'magazi kapena oxidation ofunika wamwazi chifukwa cha kuchuluka kwa matupi a ketone. Chizindikiro cha izi chidzakhala kupweteka kwambiri m'mimba, kupuma movutikira, kugona, komanso kununkhira kwachilendo, kopanda chiberekero.
3. matenda a chiwindi ndi impso,

Zovuta kwambiri zomwe zingayambitse matenda a impso, mwachitsanzo:

• matenda opatsirana
• kuchepa kwamadzi ambiri chifukwa chosanza kapena kutsegula m'mimba,
• magazi osakwanira
• pakakhala kofunikira kuyambitsa wothandizira wosiyana ndi ayodini. Izi zitha kufunikira pamaphunziro osiyanasiyana azachipatala, monga x-ray,

Kwa matenda omwe angayambitse kufa ndi oxygen, mwachitsanzo:

1. kulephera kwa mtima
2. kuwonongeka kwaimpso,
3. magazi osakwanira
4. vuto la mtima waposachedwa
5. pa kuledzera kwambiri, komanso uchidakwa.

Ngati muli ndi pakati komanso mkaka wa m'mawere, kugwiritsa ntchito Siofor 1000 kumaletsedwanso. Zikatero, adotolo ayenera kulandira mankhwalawo ndi kukonzekera insulin.

Chimodzi mwa zinthu izi chitachitika, muyenera kudziwitsa dokotala za matendawo.

Ntchito ndi mlingo

Mankhwala a Siofor 1000 ayenera kumwedwa molondola kwambiri monga adanenera dokotala. Pazinthu zilizonse zomwe zikuwonetsa zovuta, muyenera kufunsa dokotala.

Mlingo wa ndalama uyenera kutsimikiziridwa munthawi iliyonse. Nthawiyo idzakhazikitsidwa malinga ndi kuchuluka kwa shuga m'magazi. Izi ndizofunikira kwambiri pochiza odwala onse.

Siofor 1000 imapangidwa piritsi. Piritsi lililonse limakhala lophimba ndipo lili ndi 1000 mg ya metformin. Kuphatikiza apo, pali mtundu wa kumasulidwa kwa mankhwalawa mu mawonekedwe a mapiritsi a 500 mg ndi 850 mg ya chinthu chilichonse.

Njira zotsatirazi zochiritsira zikhala zowona:

• kugwiritsa ntchito Siofor 1000 ngati mankhwala odziyimira pawokha,
• kuphatikiza mankhwala pamodzi ndi mankhwala ena amkamwa omwe amachepetsa shuga ya magazi (mwa odwala achikulire),
• mogwirizana ndi insulin.

Odwala achikulire

Mlingo woyambira wokhazikika udzakhala wopaka mapiritsi okhala ndi piritsi (iyi ingafanane ndi 500 mg ya metformin hydrochloride) katatu patsiku kapena 850 mg ya chinthu katatu patsiku (kumwa kwa Siofor 1000 sikungatheke), malangizo zikuwonetseratu.

Pambuyo masiku 10-15, dokotala wopezekapo amasintha mlingo wofunikira malinga ndi kuchuluka kwa shuga m'magazi. Pang'onopang'ono, kuchuluka kwa mankhwalawa kumawonjezereka, chomwe chimakhala chinsinsi chololera bwino mankhwalawa kuchokera kugaya chakudya.

Mukasintha, mlingo udzakhala motere: 1 piritsi Siofor 1000, yokutidwa, kawiri pa tsiku. Voliyumu yowonetsedwa ikugwirizana ndi 2000 mg ya metformin hydrochloride mu maola 24.

Mulingo wambiri watsiku ndi tsiku: piritsi limodzi la Siofor 1000, yokutidwa, katatu patsiku. Voliyumu imafanana ndi 3000 mg ya metformin hydrochloride patsiku.

Ana kuyambira zaka 10

Mulingo wamba wa mankhwalawa ndi 0,5 ga piritsi yovindikira (izi zimafanana ndi 500 mg ya metformin hydrochloride) katatu patsiku kapena 850 mg ya chinthu 1 nthawi patsiku (mlingo woterewu ndiwosatheka).

Pakatha milungu iwiri, adokotala amasintha mlingo woyenera, kuyambira pakumata kwa magazi m'magazi. Pang'onopang'ono, voliyumu ya Siofor 1000 ichulukira, yomwe imakhala njira yabwino kwambiri yololera kwa mankhwalawa kuchokera m'matumbo am'mimba.

Mukasintha, mlingo udzakhala motere: piritsi 1, yokutidwa, kawiri pa tsiku. Voliyumu yotere imafanana ndi 1000 mg ya metformin hydrochloride patsiku.

Kuchuluka kwazomwe zingagwire ntchito kudzakhala 2000 mg, yomwe ikufanana ndi piritsi limodzi la kukonzekera kwa Siofor 1000, yokutidwa.

Zochita Zosiyanasiyana

Monga mankhwala aliwonse, Siofor 1000 imatha kuyambitsa zovuta zina, koma amatha kuyamba kukhala kutali ndi odwala onse omwe amamwa mankhwalawa.

Ngati mankhwala osokoneza bongo agwiritsidwa ntchito, ndiye kuti mukuyenera kutero muzipempha thandizo kuchipatala msanga.

Kugwiritsa ntchito voliyumu yambiri sikumayambitsa kuchepa kwakukulu kwa kuchuluka kwa shuga m'magazi (hypoglycemia), komabe, pali kuthekera kwakukulu kwa kuthamanga kwa magazi a wodwala ndi lactic acid (lactate acidosis).

Mulimonsemo, chithandizo chamankhwala mwadzidzidzi ndi chithandizo kuchipatala ndizofunikira.

Kuchita ndi mankhwala ena

Ngati kugwiritsa ntchito mankhwalawa kwaperekedwa, ndiye pankhani iyi ndikofunikira kwambiri kudziwitsa dokotala za mankhwala omwe agwiritsidwa ntchito ndi odwala omwe ali ndi matenda osokoneza bongo mpaka posachedwapa. M'pofunika kutchulanso ngakhale mankhwala oledzera.

Ndi mankhwala a Sifor 1000, pali mwayi wa madontho osayembekezeka m'magazi oyambira kumene pa chithandizo, komanso mukamaliza mankhwala ena.Munthawi imeneyi, shuga wa glucose amayenera kuyang'aniridwa mosamala.

Ngati chimodzi mwa zotsatirazi zikugwiritsidwa ntchito, ndiye kuti izi siziyenera kunyalanyazidwa ndi dokotala:

• corticosteroids (cortisone),
• mitundu ina ya mankhwala omwe angagwiritsidwe ntchito ndi kuthamanga kwa magazi kapena kusakwanira kwa minofu ya mtima,
• okodzetsa omwe amagwiritsidwa ntchito kuchepetsa magazi (okodzetsa),
• mankhwala ochotsa matenda amphumo a bronchial (beta sympathomimetics),
• mankhwala osiyana okhala ndi ayodini
• mankhwala okhala ndi mowa,

Ndikofunika kuchenjeza madotolo pakugwiritsa ntchito mankhwalawa omwe angawononge mawonekedwe a impso:

• mankhwala ochepetsa kuthamanga kwa magazi,
• mankhwala omwe amachepetsa zizindikiro za kupuma kwamphamvu ma virus kapena rheumatism (kupweteka, kutentha thupi).

Njira zopewera kupewa ngozi

Pochita mankhwala ndi kukonzekera kwa Siofor 1000, ndikofunikira kutsatira njira inayake yazakudya ndikumvetsera kwambiri pakumwa zakudya zamatumbo. Ndikofunika kudya zakudya zokhala ndi wowuma kwambiri momwe mungathere:

Ngati wodwalayo ali ndi mbiri yakukula kwambiri kwa thupi, ndiye kuti muyenera kutsatira zakudya zapadera zopatsa mphamvu. Izi ziyenera kuchitika moyang'aniridwa ndi adokotala.

Kuti muwonetsetse nthawi ya matenda ashuga, muyenera kuyezetsa magazi nthawi zonse.

Siofor 1000 singayambitse hypoglycemia. Ngati mugwiritsidwa ntchito munthawi yomweyo ndi mankhwala ena a shuga, mwayi wothamanga kwambiri m'magazi a glucose ukhoza kuchuluka. Tikulankhula za insulin ndi kukonzekera kwa sulfonylurea.

Ana ochokera zaka 10 ndi achinyamata

Asanayambe kugwiritsa ntchito Siofor 1000 kwa anthu am'badwo uno, endocrinologist ayenera kutsimikizira kukhalapo kwa matenda ashuga a 2 odwala.

Therapy mothandizidwa ndi mankhwalawa amachitika ndikusintha kwa zakudya, komanso ndi kulumikizana kwakanthawi kokwanira.

Zotsatira za kafukufuku wazaka wazaka chimodzi, zotsatira za mankhwala ophatikizira a Siofor 1000 (metformin hydrochloride) pakukula, kukula, ndi kutha kwa ana sizinakhazikitsidwe.

Pakadali pano, palibe maphunziro omwe adachitidwa.

Kuyesaku kunakhudza ana azaka 10 mpaka 12.

Malangizo apadera

Siofor 1000 sinathe kukhudza kuyendetsa bwino magalimoto ndipo sizikhudza mtundu wa machitidwe.

Pazomwe zimagwiritsidwa ntchito munthawi yomweyo ndi mankhwala ena othandizira odwala matenda a shuga mellitus (insulin, repaglinide kapena sulfonylurea), zitha kukhala zosemphana ndi kuyendetsa magalimoto chifukwa chakuchepa kwa magazi a wodwala.