Vipidia, akufanizira Russian mankhwala ndi mitengo ndi ndemanga

Vipidia (mapiritsi) Kukala: 183

Wopanga: Ikufotokozedwa
Kutulutsa Mafomu:

• Tab. 12,5 mg, 28 ma PC., Mtengo kuchokera ku ma ruble 973
• Tab. 25 mg, 28 ma PC., Mtengo kuchokera ku ma ruble a 1282

Mitengo ya Vipidia m'mafakitoreti apulogalamu
Malangizo ogwiritsira ntchito

Vipidia ndi othandizira a hypoglycemic pamapiritsi okhala ndi alogliptin. Amapereka kuchepa kwa glycosylated hemoglobin ndi glucose. Amasonyezedwa ngati pali mtundu wa shuga wachiwiri wa mtundu wa 2 mellitus mu mawonekedwe a monotherapy, komanso kuphatikiza mankhwala ndi ena othandizira a hypoglycemic. Mlingo woyenera ndi 25 mg / tsiku, amatengedwa mosasamala chakudya. Wolemba mu matenda ashuga ketoacidosis, mtundu 1 shuga mellitus, mtima kwambiri kulephera, aimpso ndi chiwindi kulephera. Zotsatira zoyipa zingaphatikizepo kupweteka kwa mutu, kupweteka kwa epigastrium, zotupa, matenda opatsirana a ziwalo za ENT. Ana ochepera zaka 18 ndi amayi apakati samayikidwa chifukwa chosowa chidziwitso pazomwe zimachitika.

Mndandanda wa mankhwala Vipidia

Analogue ndiotsika mtengo kuchokera ku ma ruble 863.

Wopanga: Merck Sante SAA.S. (France)
Kutulutsa Mafomu:

• Mapiritsi 500 mg, 30 ma PC., Mtengo kuchokera ku ma ruble 110
• Mapiritsi 1000 mg, 30 ma PC., Mtengo kuchokera ku ma ruble 185

Mitengo ya Glucophage m'mafakitale opezeka pa intaneti
Malangizo ogwiritsira ntchito

French mankhwala zochizira mtundu 2 shuga. Kugulitsidwa pamapiritsi okhala ndi 500 mpaka 1000 mg ya metformin monga chokhacho chophatikiza. Pali zotsutsana, motero, musanatenge Glucofage, ndikofunikira kufunsa katswiri.

Analogue ndiyotsika mtengo kuchokera ku ma ruble 182.

Wopanga: Novartis (Switzerland)
Kutulutsa Mafomu:

• Mapiritsi 50 mg, 28 ma PC., Mtengo kuchokera ku 791 rubles
• Mapiritsi 1000 mg, 30 ma PC., Mtengo kuchokera ku ma ruble 185

Mitengo ya Galvus m'masitolo ogulitsa pa intaneti
Malangizo ogwiritsira ntchito

Galvus ndi piritsi lokonzekera mankhwalawa a mtundu 2 a shuga omwe amachokera ku vildagliptin mu mlingo wa 50 mg. Itha kuthandizidwa monga monotherapy komanso ngati gawo limodzi la mankhwala othandizira pakakhala zovuta kudya komanso kuchita masewera olimbitsa thupi.

Analogue ndiotsika mtengo kuchokera ku ma ruble 795.

Wopanga: Hemofarm A.D. (Serbia)
Kutulutsa Mafomu:

• Tab. 500 mg, 60 ma PC., Mtengo kuchokera 178 ma ruble
• Mapiritsi 1000 mg, 30 ma PC., Mtengo kuchokera ku ma ruble 185

Mitengo ya Metformin muma pharmacistine apamtaneti
Malangizo ogwiritsira ntchito

Metformin ndi mankhwala achi Serbia hypoglycemic ogwiritsira ntchito mkati. Kuphatikizika kwa mapiritsi kumakhala ndi chophatikizira cha dzina lomweli muyezo wa 500 kapena 850 mg. Amalembera mankhwalawa mtundu wa matenda ashuga 2 (achikulire), makamaka ngati ali ndi kunenepa kwambiri.

Analogue ndiokwera mtengo kwambiri kuchokera ku ma ruble 799.

Wopanga: Bristol Myers squibb (USA)
Kutulutsa Mafomu:

• Mapiritsi a 5 mg, ma PC 30., Mtengo kuchokera ku 1772 rubles
• Mapiritsi 1000 mg, 30 ma PC., Mtengo kuchokera ku ma ruble 185

Mitengo ya Onglisa m'mafakitale opezeka pa intaneti
Malangizo ogwiritsira ntchito

Onglisa ndi mankhwala aku America pochiza matenda a shuga 2 omwe amachokera pa saxagliptin mu gawo la 2,5 kapena 5 mg. Amawonjezera kuwonjezera pa zolimbitsa thupi ndi zakudya kuti azitha kusintha glycemic control.

Analogue ndiokwera mtengo kwambiri kuchokera ku ma ruble a 1236.

Wopanga: Merck Sharp ndi Dome (USA)
Kutulutsa Mafomu:

• Mapiritsi 100 mg, 28 ma PC., Mtengo kuchokera ku ma 900 rubles
• Mapiritsi 1000 mg, 30 ma PC., Mtengo kuchokera ku ma ruble 185

Mitengo ya Januvia muma drug online
Malangizo ogwiritsira ntchito

Januvia ndi mankhwala ku America a matenda ashuga. Zogwira pophika: sitagliptin (mwanjira ya phosphate monohydrate) 100 mg. Itha kugwiritsidwa ntchito ngati kuwonjezera pa zolimbitsa thupi ndi zakudya kuti muchepetse shuga.

Analogue ndiokwera mtengo kwambiri kuchokera ku ma ruble 675.

Wopanga: Beringer Ingelheim (Austria)
Kutulutsa Mafomu:

• Mapiritsi a 5 mg, ma PC 30., Mtengo kuchokera ku ma ruble 1648
• Mapiritsi 1000 mg, 30 ma PC., Mtengo kuchokera ku ma ruble 185

Mitengo ya Trazhenta muma pharmacin opezeka pa intaneti
Malangizo ogwiritsira ntchito

Trazhenta - mankhwala a ku Austria opangidwa pochiza matenda a shuga 2, angathe kuikidwa onse ngati mankhwala osokoneza bongo. Chokhacho chokhacho chophatikizidwa ndi linagliptin mu mlingo wa 5 mg. Trazenta sinafotokozeredwe mtundu woyamba wa matenda ashuga, pa nthawi yoyembekezera, mkaka wa m'mawere, komanso mwa ana osakwana zaka 18.

Vipidia: malangizo ogwiritsira ntchito, mtengo, ndemanga ndi analogi

Vipidia ndi mankhwala omwe amagwiritsidwa ntchito molingana ndi malangizo ogwiritsira ntchito shuga. Odwala omwe ali ndi vutoli ayenera kuyang'anitsitsa glucose wamagazi pogwiritsa ntchito chakudya chokhazikika, ndipo ngati sikokwanira, ndiye mankhwala.

Kutulutsa mawonekedwe, kapangidwe kake ndi ma CD

Mankhwala amapangidwa mwa mawonekedwe a mapiritsi ozungulira omwe amaphatikizidwa ndi nembanemba wamafilimu. Mlingo:

• 12,5 mg - mapiritsi achikasu
• 25 mg - tint yofiirira.

Chogulitsachi chimagulitsidwa m'makatoni. Kuyika: matumba 4, okhala ndi mapiritsi 7, zidutswa 28 za paketi yonse.

Chithandizo chogwira mankhwalawa ndi alogliptin. Zinthu Zothandiza:

• magnesium wakuba,
• sodium croscarmellose,
• cellcrystalline mapadi,
• Hyprolose

Makanema ophatikizira piritsi amatanthauza:

• hypopellose,
• Utoto wa oxide wachitsulo
• titanium dioxide
• macrogol
• inki imvi F1

Zochita zamankhwala

Alogliptin ndi dipeptidyl peptidase-4 inhibitor yosankha kwambiri. DPP-4 ndiye puloteni yayikulu yomwe imayambitsa kusokonekera mwachangu kwa mahomoni a banja la ma impretin.

Makamaka, ndi glucose-insulinotropic polypeptide (HIP) yokhala ndi glucagon-peptide-1 (GLP-1). Ma mahomoni amenewa amapangidwa m'matumbo, ndipo msinkhu wake umasiyanasiyana kutengera ndi chakudya chomwe mumadya.

Zotsatira za HIP ndi GLP-1 zimayambitsa kukhazikitsa kaphatikizidwe ka insulin mwachindunji mu kapamba.

Glucagon-ngati peptide imathandizira kuchepetsa kuchuluka kwa glucagon ndikuchepetsa kupanga glucose m'chiwindi.

Kusintha kulikonse kwa kuchuluka kwa ma insretins motsogozedwa ndi alogliptin, kupanga kwa insulin kumawonjezera ndipo glucagon amachepetsa ndi shuga wowonjezereka.

Mwa anthu omwe ali ndi matenda ashuga, kusintha kotereku kumapangitsa kuti glycosylated hemoglobin komanso magawo ena amkati asanadye komanso pambuyo pake.

Pharmacokinetics

Mankhwalawa amathandizanso munthu wathanzi komanso wodwala matenda ashuga. Alogliptin amalowetsedwa m'thupi ndi pafupifupi 100%, mosasamala kanthu za chakudya chomwe chimadyedwa. Ndi piritsi limodzi, chinthu chogwira chimalowa mwachangu m'magazi, pomwe maola 1 mpaka 2 amwe mankhwalawa amapezeka.

Alogliptin imakonda kugawidwa bwino mu minofu. Ubwenzi ndi mapuloteni a plasma pafupifupi 20-30%.

Ndi kugwiritsa ntchito mankhwalawa kwa nthawi yayitali, kudzikundikira kwa chinthu chamoyo m'thupi, malinga ndi kuchuluka kwa manambala, sikuwoneka mwa anthu athanzi kapena odwala.

Pakupita maola 21 mutamwa mankhwalawa, 70% ya mankhwala amapezeka ndi impso m'malo osasinthika, 13% ndi matumbo.

Vipidia imalembedwa mtundu wa shuga. Chidacho chimathandizira odwala, ngakhale osagwirizana ndi zakudya komanso kusowa kochita zolimbitsa thupi. Mankhwala angagwiritsidwe ntchito ngati monotherapy. Mutha kumwa nawo limodzi ndi mankhwala ena omwe amathandizira kuchepetsa kuchuluka kwa shuga m'magazi.

Contraindication

Monga mankhwala aliwonse, Vipidia ili ndi malire ake. Werengani iwo mosamala.

Mankhwala sayenera kumwa ndi:

• Hypersensitivity thupi kwa chilichonse chomwe chiri gawo la mankhwala,
• mtundu 1 shuga
• matenda ashuga ketoacidosis,
• kulephera kwa mtima kosatha
• kuvulala kwambiri kwa chiwindi,
• Mimba ndi kuyamwa
• ana ochepera zaka 18.

Musamale:

• kapamba
• kulephera kwapakati pamiyendo,

Malangizo ogwiritsira ntchito (mlingo)

Vipidia amayenera kumwedwa pakumwa asanadye komanso atatha kudya. Ndikulimbikitsidwa kugwiritsa ntchito osaposa 25 mg pa tsiku. Nthawi zina amawapangira limodzi ndi mankhwala ena, monga:

Ndi othandizira a Vipidia okhala ndi metformin kapena thiazolidatedione, mlingo umakhalabe wosasinthika. Kupatula chiopsezo cha hypoglycemia, mankhwala akapatsidwa mankhwala nthawi yomweyo ndi insulin, ndikofunikira kuchepetsa Mlingo wotsatira. Ngati pazifukwa zina mukuyiwala kumwa mankhwalawo, muyenera kukonza mwachangu. Koma nthawi imodzi mlingo wowirikiza suyenera kumwa.

Zotsatira zoyipa

Pali nthawi zina pamene zizindikiro zosasangalatsa zimachitika chifukwa cha mankhwala a Vipidia. Wodwala angadandaule za:

• mutu
• kupuma matenda
• nasopharyngitis,
• kupweteka m'mimba
• kuyabwa ndi zotupa pakhungu,
• chitukuko cha kapamba,
• mapangidwe aimpso kulephera.

Ngati zizindikilo zowopsa ngati izi zizindikiridwa, muyenera kudziwitsa dokotala. Ndi iye yekha amene angasankhe kupitiliza kumwa mankhwalawo kapena ayi. Kuwonetsera kwakukulu kwa zizindikiro zomwe zili pamwambapa kumafuna kusiya mankhwala mwachangu.

Bongo

Kuchulukitsa mwangozi sikuopseza anthu. Kuthandizidwa ndi dokotala kumafunika pokhapokha ngati kuli kosagwirizana ndi Vipidia kapena mukamamwa mankhwala ndi anthu omwe akudwala matenda omwe ali pamndandanda wazotsutsana. Thandizo loyamba la bongo - chapamimba.

Malangizo apadera

Kugwiritsira ntchito kwa Vipidia ndi insulin ndi mankhwala ena omwe amachepetsa shuga ya magazi kumafuna kusintha kwa mankhwalawa kuti mupewe kukula kwa hypoglycemia. Malinga ndi kafukufuku wazachipatala, kulumikizana kwa alogliptin ndi zida zina zamankhwala sikuwonetsa kusintha.

Alogliptin imakhudza thupi kwambiri, kotero panthawi ya chithandizo muyenera kukana kumwa mowa.

Mankhwala "Vipidia" samayambitsa kugona, kotero kuyendetsa galimoto ndi zochitika zina zomwe zimafunikira chidwi chochuluka siziletsedwa.

Chofunikira: Kafukufuku wasonyeza kuti mankhwalawa samakhudza chiwindi kwambiri, akumaphwanya mbali zina zake. Kufikira pomwe pancreatitis yachilendo imatha kuchitika. Chifukwa chake, musanagwiritse ntchito mankhwalawa, ndikofunikira kuyesedwa ndikuyerekeza zabwino ndi zowawa zilizonse.

Chifukwa chosowa zambiri zokhudzana ndi zovuta pamimba komanso mkaka wa m'mawere, ndibwino kuti musamwe Vipidia.

Ana ndi ukalamba

Kupereka mankhwala kwa ana ndi achinyamata osakwana zaka 18 zakubadwa, chifukwa cha kusowa kwazidziwitso zamankhwala pazaka izi.

Odwala a zaka zopitilira 60 amatha kumwa "Vipidiya". Mlingo wanthawi zonse sofunikira kusintha. Komabe, ziyenera kukumbukiridwa kuti kuthekera kwa kuchepa kwa kugwira ntchito kwa impso ndi chiwindi zimatengera kuchuluka kwa alogliptin.

Migwirizano ndi magwiritsidwe akusungidwa

Sungani mankhwalawo pamalo amdima, ozizira kutali ndi ana. Nthawi yogwiritsira ntchito ndi zaka zitatu kuyambira tsiku lomwe adatulutsa. Tsiku lopanga limamangiriridwa kumayikidwe. Mankhwala omwe atha ntchito amaletsedwa.

Mtengo wa Vipidia m'masitolo amasiyana pamitengo ya mankhwalawo komanso dera lomwe mukukhalamo. Pa avareji, ndi 845 - 1390 rubles.

Fananizani ndi fanizo

Ngati pazifukwa zina mankhwalawo sagwirizana ndi wodwalayo, adokotala amafunafuna mankhwala omwe atha kusintha.

Mndandanda wa mankhwala "Vipidia":

Dzinalo	Mapindu ake	Zoyipa	Mtengo
Galvus Met	Njira yothandiza yochepetsera shuga. Zimathandizanso kuchotsa mapaundi owonjezera popanda kudya mokakamizidwa.	Mndandanda waukulu wazotsatira zoyipa. Mtengo wokwera wa mankhwalawo.	Kuchokera pa ruble 780.
Alogliptin	Zimathandizira kusintha misinkhu ya shuga. Sizimayambitsa kuchuluka kwa kagayidwe. Sichikundikira, imachotsedwa kwathunthu ku thupi.	Sitha kugwiritsidwa ntchito pa matenda a impso, chiwindi, kapamba. Mankhwala siotsika mtengo.	Kuchokera ku 845 rubles.
Januvia	Chimalimbikitsa kuwonda, amachepetsa kudya, amateteza magawo a magazi.	Mtengo: Pali zotsutsana zambiri zogwiritsidwa ntchito, chifukwa chake ndikofunikira kuti dokotala amupatseni mankhwala.	Kuyambira 1350 rubles

Mayankho ambiri ochokera kwa odwala matenda ashuga omwe atenga Vipidia ndi abwino. Mapiritsiwa amachepetsa shuga m'magazi, amaloledwa bwino, koma ayenera kugwiritsidwa ntchito pokhapokha ngati akuwuzani dokotala. Anthu sakonda zoti mankhwalawa ndi okwera mtengo. Nawa malingaliro enieni:

Ndinapezeka ndi matenda ashuga zaka 5 zapitazo. Adalembedwa ndi endocrinologist, amamwa mankhwala ambiri. Koma masabata angapo apitawa, shuga adayamba kukwera mpaka 18. Dokotala adandiwuza Vipidia. Ndimamwa piritsi limodzi patsiku, shuga ndi abwinobwino. Ndili wokondwa kwambiri. Inemwini ndinapeza mu mankhwalawa mwayi umodzi wokha.

Vipidia imalowa m'malo mwa insulin bwino kwambiri. Ndipo poyerekeza ndi iyo, mankhwalawo amangofunika kumwa kamodzi patsiku. Sikufunika kusunga zakudya. Ndili ndi matenda ashuga, mapiritsi amatengera kuchuluka kwa shuga m'magazi, chifukwa chake ndidakana kale insulin. Chowonadi chimasokoneza pang'ono pamtengo, mankhwalawa siotsika mtengo, si aliyense angakwanitse kugula. Koma, zoona, pali ma pluses. Ndikupangira izi kwa aliyense.

Ndili ndi matenda ashuga a 2. Analandira chithandizo, adamwa mankhwala tsiku lililonse, koma glucose ndiye amachepetsa, kenaka adakulanso mpaka mayunitsi 12. Panali zochitika za hypoglycemic zimachitika, kutsika kwamphamvu kwa shuga.

Dokotala adandiwuza Vipidia. Ndimakondwera kwambiri ndi mankhwalawa. Ndimamwa piritsi limodzi lokha m'mawa ndipo zonse zili bwino. Ngakhale ndizodula, koma sindimawona kusinthasintha kwa magawo a magazi ndikukhazikika tsiku lonse.

Adotolo adandipatsa mankhwala oti ndigule mankhwalawa "Vipidia". Ndadwala matenda ashuga kwa zaka zingapo. Ndinkakonda mankhwalawa, amachepetsa zikhazikitso za shuga. Ndimamwa kamodzi kokha patsiku.

Ilibe zotsutsana mukamacheza ndi mankhwala ena, zomwe ndizosangalatsa kwambiri. Zilibe kukhudzana ndi psyche ndipo sizimayambitsa kugona. Kuyendetsa galimoto ndi iye sikuletsedwa.

Ndine wokhutira ndi chilichonse, mankhwala othandiza omwe sanayambitse mavuto ena.

Mapiritsi a Vipidia - malangizo ogwiritsira ntchito ndi analog mankhwala

Matenda a shuga ndi matenda ofala kwambiri komanso owopsa. Odwala omwe ali ndi vutoli ayenera kuyang'anitsitsa shuga wawo wamagazi ndikuwongolera ndi mankhwala, apo ayi zotsatira zake zingakhale zakupha.

Ichi ndichifukwa chake ndikofunikira kudziwa momwe mankhwalawa amapangidwira kuthana ndi zizindikiro za matenda. M'modzi mwa iwo ndi Vipidia.

Zambiri zamankhwala

Chida ichi chikunena za zomwe zachitika posachedwa pa shuga. Ndizoyenera kwa anthu omwe ali ndi matenda a shuga a 2. Vipidia ikhoza kugwiritsidwa ntchito yokhayokha komanso molumikizana ndi mankhwala ena a gululi.

Muyenera kumvetsetsa kuti kugwiritsa ntchito mankhwalawa mosasamala kumatha kudwalitsa wodwala, chifukwa chake muyenera kutsatira malingaliro a dokotala. Simungagwiritse ntchito mankhwalawa osaneneka, makamaka mukamamwa mankhwala ena.

Dzinali lomwe limagulitsidwa mankhwalawa ndi Vipidia. Padziko lonse lapansi, dzina loti Alogliptin limagwiritsidwa ntchito, lomwe limachokera ku chinthu chachikulu chomwe chimapanga.

Choyimiracho chikuyimiriridwa ndi mapiritsi okhala ndi mawonekedwe owonera filimu. Amatha kukhala achikasu kapena ofiira owala (zimatengera mlingo). Phukusi limaphatikizapo 28 ma PC. - Malonda 2 mapiritsi 14.

Kutulutsa mawonekedwe ndi kapangidwe kake

Mankhwala Vipidia amapezeka ku Ireland. Mtundu wa kumasulidwa kwake ndi magome. Ndizosankha zamitundu iwiri, kutengera zomwe zili pompopompo - 12,5 ndi 25 mg. Mapiritsi okhala ndi mphamvu yochepa yogwira amakhala ndi chipolopolo chachikaso, chokhala ndi chokulirapo - chofiyira. Pazigawo zilizonse pamakhala zolembedwa pomwe mulingo ndi wopanga akuwonetsedwa.

Chofunikira chachikulu pa mankhwalawa ndi Alogliptin Benzoate (17 kapena 34 mg piritsi lililonse). Kuphatikiza apo, zinthu zothandiza zimaphatikizidwa ndi kapangidwe kake, monga:

• cellcrystalline mapadi,
• mannitol
• Hyprolose
• olimba ndi magnesium,
• croscarmellose sodium.

Zotsatirazi ndizomwe zili mu filimuyo:

• titanium dioxide
• hypromellose 29104
• macrogol 8000,
• utoto wachikasu kapena wofiyira (iron oxide).

Zotsatira za pharmacological

Chida ichi ndichotengera Alogliptin. Ichi ndi chimodzi mwazinthu zatsopano zomwe zimagwiritsidwa ntchito kuwongolera shuga. Ndi gawo la kuchuluka kwa hypoglycemic, ili ndi mphamvu.

Mukamagwiritsa ntchito, pali kuwonjezeka kwa katemera wa shuga yemwe amadalira glucose pomwe amachepetsa kupanga shuga.

Ndi matenda a shuga a 2, omwe amaphatikizidwa ndi hyperglycemia, mawonekedwe awa a Vipidia amathandizira kusintha kotere monga:

• kutsika kwa kuchuluka kwa hemoglobin ya glycated (НbА1С),
• kutsitsa shuga.

Izi zimapangitsa chida ichi kukhala chothandiza pochiza matenda ashuga.

Zizindikiro ndi contraindication

Mankhwala omwe amadziwika ndi kuchitapo kanthu mwamphamvu amafunikira kusamala kuti mugwiritse ntchito. Malangizo a iwo akuyenera kuwunikidwa mosamala, m'malo mwake amapindulitsa thupi la odwala. Chifukwa chake, mutha kugwiritsa ntchito Vipidia pokhapokha akutsimikizirani katswiri mosamalitsa pazotsatira.

Chipangizocho chikuvomerezedwa kuti chizigwiritsidwa ntchito ndi matenda a shuga a 2. Imakhala ndi malamulo a kuchuluka kwa glucose pokhapokha ngati chithandizo cha mankhwala sichigwiritsidwa ntchito ndipo zolimbitsa thupi sizofunikira. Gwiritsani ntchito bwino mankhwala a monotherapy. Amaloledwanso kugwiritsidwa ntchito kwake pamodzi ndi mankhwala ena omwe amathandizira kuchepetsa shuga.

Kusamala mukamagwiritsa ntchito mankhwalawa amayamba chifukwa cha kuponderezedwa. Ngati sangalandiridwe, chithandizo sichingagwire ntchito ndipo chingayambitse zovuta.

Vipidia saloledwa pamilandu yotsatirayi:

• tsankho limodzi ndi zigawo za mankhwala,
• mtundu 1 shuga
• kulephera kwamtima kwambiri
• matenda a chiwindi
• kuvulala kwambiri kwa impso
• Mimba ndi kuyamwa
• kukula kwa ketoacidosis yoyambitsidwa ndi matenda ashuga,
• zaka wodwala zafika 18.

Zophwanya izi ndizotsutsana kwambiri pakugwiritsa ntchito.

Palinso mayiko omwe mankhwalawa amalembedwa mosamala:

• kapamba
• aimpso kulephera zolimbitsa.

Kuphatikiza apo, chisamaliro chimayenera kuthandizidwa popereka Vipidia limodzi ndi mankhwala ena kuti azitha kuyendetsa shuga.

Zotsatira zoyipa

Pochiza ndi mankhwalawa, nthawi zina zizindikiro zosagwirizana ndi zotsatira za mankhwalawa zimachitika:

• mutu
• matenda opuma
• nasopharyngitis,
• kupweteka m'mimba
• kuyabwa
• zotupa pakhungu,
• pachimake kapamba
• urticaria
• Kukula kwa chiwindi kulephera.

Zotsatira zoyipa zikachitika, pitani kuchipatala. Ngati kupezeka kwawo sikuwononga thanzi la wodwalayo, komanso kulimba kwake sikukula, chithandizo cha Vipidia chitha kupitilizidwa. Vuto lalikulu la wodwalayo limafuna kuchotsedwa kwa mankhwalawo mwachangu.

Mlingo ndi makonzedwe

Mankhwalawa amapangidwira pakamwa. Mlingo amawerengedwa payekha, molingana ndi kuopsa kwa matendawa, zaka za wodwalayo, matenda ofanana ndi zina.

Pafupifupi, amayenera kutenga piritsi limodzi lokhala ndi 25 mg ya mankhwala othandizira. Mukamagwiritsa ntchito Vipidia mu mlingo wa 12,5 mg, kuchuluka kwa tsiku ndi tsiku ndi mapiritsi awiri.

Ndikulimbikitsidwa kumwa mankhwalawa kamodzi patsiku. Mapiritsi ayenera kuledzera kwathunthu osafuna kutafuna. Ndikofunika kumwa iwo ndi madzi owiritsa. Ch phwando chololedwa chovomerezeka musanadye komanso pambuyo chakudya.

Osagwiritsa ntchito mankhwalawa pawiri ngati mankhwala atasowa - izi zitha kuyipa. Muyenera kumwa mankhwala mwachizolowezi posachedwa.

Kukonzekera kofananako

Ngakhale palibe mankhwala omwe angakhale ndi mawonekedwe omwewo ndi zotsatira zake. Koma pali mankhwala omwe ali ofanana pamtengo, koma opangidwa kuchokera ku zinthu zina zomwe zingagwire ntchito ngati analogues a Vipidia.

Izi zikuphatikiza:

1. Januvia.Mankhwala awa tikulimbikitsidwa kuti muchepetse shuga. Chosakaniza chophatikizacho ndi sitagliptin. Amatchulidwa mu milandu yomweyo Vipidia.
2. Galvus. Mankhwalawa amachokera ku Vildagliptin. Katunduyu ndi analog wa Alogliptin ndipo ali ndi katundu yemweyo.
3. Janumet. Ichi ndi mankhwala ophatikiza ndi hypoglycemic effect. Zofunikira zake ndi Metformin ndi Sitagliptin.

Ma pharmacist amathanso kupereka mankhwala ena kuti asinthe Vipidia. Chifukwa chake, sikofunikira kubisala kwa dokotala kusintha kwakuthupi komwe kumachitika chifukwa cha kudya.

Maganizo a odwala

Kuchokera pakuwunika kwa odwala omwe akutenga Vipidia, zitha kutsimikizika kuti mapiritsiwo amathandizidwa bwino ndikuthandizira kuti pakhale shuga wambiri wamagazi, koma ayenera kumwedwa mosamala mogwirizana ndi malangizo, ndiye kuti zovuta zoyambira ndizosowa kwenikweni ndipo zimazimiririka msanga.

Vidiyo pazomwe zimayambitsa, zizindikiro ndi chithandizo cha matenda ashuga:

Mtengo wa Vipidia umatha kukhala osiyana m'mafakitala m'mizinda yosiyanasiyana. Mtengo wa mankhwalawa muyezo wa 12.5 mg umasiyana kuchokera ku 900 mpaka 1050 rubles. Kugula mankhwala okhala ndi mlingo wa 25 mg kumawononga ndalama zambiri - kuyambira 1100 mpaka 1400 rubles.

Sungani mankhwalawa amadalira m'malo omwe sangathe kufikiridwa ndi ana. Kuwala kwa dzuwa ndi chinyezi sikuloledwa pa izo. Kutentha kosungira sikuyenera kupitirira 25 digiri. Zaka 3 zitamasulidwa, tsiku lotha ntchito limatha, pambuyo pake mabungwe ake saloledwa.

Adalimbikitsa Nkhani Zina Zogwirizana

Vipidia: mapiritsi awa ndi otani ndipo amathandizira bwanji ndi matenda ashuga

Vipidia ndi amodzi mwa mankhwala ambiri ochiritsira pakamwa matenda a shuga 2. Itha kugwiritsidwa ntchito onse palokha, ndiko kuti, monotherapy, komanso kuphatikiza ndi mankhwala ena.

Zomwe zimagwira - alogliptin, ndi za m'badwo watsopano, zikuyimira gulu la incretin mimetics. Amayankha pazakudya zamagetsi polimbikitsa kupanga insulin.

Mapiritsi a Vipidia a matenda a shuga amakhala ndi malingaliro abwino, omwe amachitika chifukwa cha kuchuluka kwambiri kwa mankhwalawa.

Zizindikiro zazikulu ndi zotsutsana

Zomwe zimagwiritsidwa ntchito za Vipidia zimasankha masipididyl peptidase-4 (DPP-4). Ma Analogs nthawi zambiri amagwira ntchito moipa kwambiri, omwe amawonetsedwa pazotsatira zamankhwala.

Moyo wa alumali wazinthu izi ndi zaka zitatu, pambuyo pake sizikulimbikitsidwa kuti mugwiritse ntchito.

Muyenera kusunga mankhwalawo pamalo osalumikizana ndi kuwala kwa dzuwa, ndipo kutentha sikofika 25 degrees.

Vipidia ndi mankhwala apiritsi kuti muchepetse shuga. Amagwiritsidwa ntchito pochiza matenda a shuga a 2.

Ndikulimbikitsidwa kuti muyambe kumwa mukamatsatira malangizo olimbikitsidwa pakudya limodzi ndi masewera olimbitsa thupi samapereka zomwe mukufuna.

Amaloledwa kugwiritsidwa ntchito ngati gawo la monotherapy, chithandizo chovuta ndi mankhwala ena okhala m'matumbo, komanso kuphatikiza ndi insulin.

Pali zosokoneza zingapo pakumwa mankhwalawa.

1. Kupezeka kwa sayanjana kapena hypersensitivity zilizonse zogwira ntchito kapena zothandiza zigawo za Vipidia.
2. Mtundu woyamba wa shuga.
3. Zovuta zakukula kwa kagayidwe kazakudya - ketosis, malo ochitika a hyperglycemic, hypoglycemia.
4. Kulephera kwamtima.
5. Momwe zimayendera ziwindi za chiwindi, limodzi ndi zovuta zake.
6. Matenda a impso ndi aimpso kulephera.
7. Nthawi ya pakati, kuyamwa.
8. Anthu ochepera zaka 18 nawonso saloledwa.

Mochenjera komanso moyang'aniridwa ndi achipatala, mankhwalawa amaperekedwa ngati wodwala ali ndi pancreatitis yayikulu kapena yayitali, komanso akuwonongeka pang'ono kwa impso ndi chiwindi. Pogwiritsa ntchito Vipidia monga gawo la zovuta ndi mankhwala ena, kulumikizana kwawo kuyenera kuphunzira mosamala.

Werengani komanso Zomwe muyenera kudziwa pokhudzana ndi matenda amtundu wa 2 komanso matenda a shuga.

Zotsatira zoyipa

Mukamamwa mankhwalawa, mavuto ena amayamba.

1. Mchitidwe wamanjenje umayankha ndikutulutsa mutu.
2. Njira yogaya chakudya imatha kuchitika ndi kuwonekera kwa gastroesophageal Reflux, kupweteka kwa gawo la epigastric, komanso pali zizindikiro zowonjezera pancreatitis.
3. Nthawi zina, pali kuphwanya kwachilendo kwa chiwindi, ndulu ya ndulu.
4. Kutupa kwa oropharynx.
5. Chimodzi mwazinthu zosasangalatsa zomwe zimachitika ndi kugwidwa ndi matendawa, komwe kumawonetsedwa ndi kuyabwa, edema ya Quincke, urticaria.

Phenomena wa anaphylaxis ndi osowa kwambiri, koma zotheka zimakhala.

Ngati titha kulankhula za Vipidia ndi chidwi ndi ndemanga zotsalira za odwala omwe adagwiritsa ntchito mankhwalawa, titha kunena kuti ndizothandiza kwambiri pothana ndi matenda a shuga a mtundu wachiwiri. Zimakupatsani mwayi wowongolera matendawa, khazikitsani mbiri ya glycemic, muchepetse hemoglobin ya glycosylated, yowonetsa kugwira ntchito kwa mankhwala aliwonse.

Werengani nawonso. Kodi ndizopweteka kufa ndi matenda a shuga a 2

Ichi ndi chida chapadera chomwe chiribe fanizo pakuphatikizika kwake monga lero. Ndiye kuti, padziko lapansi palibenso mankhwala ena omwe ali ndi zosakaniza zambiri za alogliptin.

Komabe, pali mankhwala ena ambiri okhudzana ndi incretomimetics. Amawerengedwa kuti ndi fanizo la Vipidia, komanso omwe amapikisana nawo pamsika wamankhwala. Odziwika komanso odziwika kwambiri m'maiko osiyanasiyana angakhale.

Chake chomwe chimagwira ndi sitagliptin. Mankhwala amagawidwa mapiritsi, Mlingo wa 25, 50, 100 milligrams. Ili ndi zofanana ndendende ndi vipidia, pomwe imagwiritsidwanso ntchito ngati gawo la monotherapy kapena kuphatikiza ndi othandizira ena.

Uku ndikupanga kophatikizidwa kwa Januvia, kapangidwe kake komwe kamakhalanso ndi Metformin. Mlingo wa sitagliptin ndi ma milligram 50, metformin imatha kukhala pamitundu itatu - 500, 850 kapena 1000 milligrams.

Ndi mankhwala osakanikirana otengera vildagliptin (chibadwa chofanana ndi alogliptin) ndi metformin. Mlingo wofanana ndi wa Yanumet.

Kupanga Kumodzi. Amapangidwa pamaziko a saxagliptin omwe amaphatikizika. Mwachilengedwe chake, amadziwika kuti ndiwowononga maretretin, ndiye kuti, ali ndi njira yosiyaniranasiyana kuposa Vipidia, koma ali m'gulu lomweli la mankhwala. Mlingo ndi ma milligram 2.5 ndi 5.

Kutalika kwa Combogliz

Awa ndi mankhwala osakanikirana omwe amaphatikizapo saxagliptin ndi metformin. Ili ndi mphamvu yayitali chifukwa kumasulidwa pang'onopang'ono kwa magawo omwe amagwira ntchito.

Lero, Vipidia ndiye mankhwala atsopano kwambiri kuchokera ku gulu la incretin mimetics. Kugwiritsidwa ntchito kwake kumawonetsa zotsatira zabwino kwambiri, ndipo mtengo wake ndiwomveka, zomwe zidapangitsa kuti ambiri endocrinologists atenga kale mankhwalawa.

Zizindikiro zogwiritsidwa ntchito

Vipidia ndi mankhwala osokoneza bongo a hypoglycemic. Amapangidwa monga mawonekedwe a mapiritsi ozungulira a chikaso kapena mtundu wofiira ndi kampani yosindikiza komanso manambala akukonza ndende ya yogwira.

Mankhwala amapangidwa mwanjira ya mapiritsi, opangidwira njira ziwiri:

• mapiritsi okhala ndi alogliptin benzoate - 12.5 mg, utoto wachikaso,
• Mapiritsi okhala ndi mphamvu yogwira 25 mg - wofiyira.

Vipidia imagwiritsidwa ntchito ngati mtundu wa shuga wachiwiri wa shuga ngati mankhwala odziimira pawokha kapena molumikizana ndi mankhwala ena omwe cholinga chake ndi kuchepetsa shuga m'magazi.

Mphamvu yogwira ya mankhwala ndi chida chatsopano chomwe chikugwirizana ndi incretinomimetics. Cholinga chawo ndikulimbikitsa thupi kuti litulutse insulin pambuyo chakudya. Gulu lazinthu izi limaphatikizanso polypeptide yokhala ndi glucose ndi insulinotropic polypeptide.

Alogliptin imasiyanitsidwa ndi kusankha kwake pokhudzana ndi enzyme dipeptidyl peptidase-4. Omaliza amatha kuwononga mahomoni kuchokera pagulu la ma insretin mwachangu kwambiri. Zitha kupangika m'matumbo ndipo, pakudya, zimathandizira kuti pakhale insulin.

Peptide yokhala ndi glucagon imachepetsa kupanga kwa glucagon, potero imachepetsa kuchuluka kwa shuga m'chiwindi. Ndi kuwonjezeka kwa kuchuluka kwa ma insretins, alogliptin amathandizira kukulitsa insulin.

Nthawi yomweyo, kuchuluka kwa glucagon kumachepa motsutsana ndi maziko a kuchuluka kwa glucose m'magazi. Njira izi zimayambitsa kutsika kwa kuchuluka kwa hemoglobin ya glycosylated mwa anthu omwe ali ndi matenda osokoneza bongo omwe amadalira insulin.

Kuphatikiza apo, kuchuluka kwa shuga m'magazi kumapangidwira onse pamimba yopanda kanthu ndikutsatira.

Vipidia ndi mankhwala othandizira omwe amagwiritsidwa ntchito kukonza mkhalidwe wa anthu omwe ali ndi matenda a shuga a mtundu II. Ntchito yake yayikulu ndikuwonjezera mphamvu ya malamulo a shuga.

Mankhwalawa amagwiritsidwa ntchito akamamwa. Mulingo woyenera wodwala ndi 25 mg. Imangotenga nthawi 1 yokha patsiku. Piritsi limamezedwa kwathunthu ndikutsukidwa ndi madzi oyera owiritsa.

Ngati izi zidachitika, ndiye kuti mumwetse mlingo wowerengeka wa lero ndipo dzulo ndizosatheka. Kulandilanso kuyenera kuchitika modzikakamiza.

Ngati Vipidia imagwiritsidwa ntchito limodzi ndi metformin kapena thiazolidinedione, ndiye kuti sizingatheke kusintha kuchuluka kwa mankhwalawa.

Kusintha kwa mankhwalawa kumapangidwa pokhapokha ngati mankhwalawa apangidwa ndi zinthu zochokera ku sulfonylurea kapena ndi insulin kuti muchepetse mwayi wa hypoglycemia. Kusamalidwa kwapadera kumafunika panthawi ya chithandizo ndi metformin ndi thiazolidinedione. Ngati zizindikiro za hypoglycemia zikuwonekera, kuchuluka kwa metformin kapena thiazolidinedione kuyenera kuchepetsedwa.

Zofananira za Vipidia

Mbale za mankhwala ndi mankhwala omwe ali ndi zosakaniza zosiyanasiyana, koma amagwiritsidwa ntchito pochiza matenda omwewo ndi zizindikiro zomwezo.

Vipidia analogi zokhala ndi alogliptin sizikupezeka. Komabe, pochita zochizira, othandizira othandizira ochokera ku gulu la incretin mimetics omwe ali ndi mawonekedwe osiyana amagwiritsidwa ntchito kwambiri. Izi zikuphatikiza ndi izi:

Chiwerengero chachikulu chotere cha ma analogu chikuwonetsa kufunikira ndi kufunika kwa mankhwalawa. Ndemanga za Vipidia ndi mankhwala ofanana kwambiri ali ndi zabwino.

Vuto lokhalo ndilakuti mankhwalawa onse omwe amawongolera kapangidwe ka shuga m'magazi a shuga ali ndi zotsutsana zambiri komanso zoyipa.

Kuphatikiza apo, kugwiritsa ntchito kwawo kumafunikira kudziwa momwe thupi lilili, kukhalapo kwa matenda ena, komanso kumafunikira kuwunikira nthawi zonse osati shuga wamagazi, komanso zizindikiro zina za thupi.

Hypoglycemic mankhwala, choletsa wamphamvu komanso wosankha kwambiri wa dipeptidyl peptidase-4 (DPP-4).

Kusankha kwake kwa DPP-4 ndizochulukirapo kuposa 10,000 zomwe zimakhudza ma enzyme ena okhudzana, kuphatikiza DPP-8 ndi DPP-9.

DPP-4 ndiye puloteni yayikulu yomwe ikukhudzidwa pakuwonongeka kwadzidzidzi kwa mahomoni a banja la maretretin: glucagon-like peptide-1 (GLP-1) ndi glucose-wodalira insulinotropic polypeptide (HIP).

Mahomoni a banja la insretin amatulutsidwa m'matumbo, chidwi chawo chimawonjezeka poyankha kudya. GLP-1 ndi HIP zimawonjezera kaphatikizidwe ka insulin ndi katulutsidwe kake ka maselo a pancreatic β.GLP-1 imalepheretsanso katulutsidwe wa glucagon ndikuchepetsa kupanga shuga wa chiwindi.

Chifukwa chake, kuchulukitsa kuchuluka kwa ma insretins, alogliptin kumakulitsa chitetezo chamatenda a glucose ndipo kumachepetsa kubisika kwa glucagon ndikuwonjezera kuchuluka kwa shuga m'magazi.

Odwala omwe ali ndi mtundu wachiwiri wa matenda a shuga omwe ali ndi hyperglycemia, kusintha kumeneku kwa insulin ndi glucagon kumapangitsa kutsika kwa kuchuluka kwa glucose mu hemblobin НbА1С ndi kuchepa kwa kuchuluka kwa shuga m'magazi am'magazi a kusala komanso glucose ya postprandial.

Vipidia - malangizo a ntchito, ma analogu

Piritsi limodzi 12,5 mg lili

Zogwira ntchito: alogliptin benzoate - 17 mg (molingana ndi alogliptin - 12.5 mg).

Zogwira ntchito: alogliptin benzoate - 34 mg (malinga ndi alogliptin -25 mg).

Othandizira:
Nucleus: mannitol 79,7 mg, microcrystalline cellulose 22,5 mg, hyprolose 4.5 mg, croscarmellose sodium 7.5 mg, magnesium stearate 1.8 mg.

Kuthira mafilimu: hypromellose 2910 5.34 mg, titaniyamu 0,6 mg, utoto wachitsuloideideide 0.06 mg, kuchuluka kwa macrogol-8000, ma inki a imvi a F1.

Kufotokozera
Mlingo wa 12.5 mg mapiritsi a Oic biconvex, wokutidwa ndi filimu yachikaso, wokhala ndi "TAK" ndi "ALG-12.5" mbali imodzi.

Wothandizira hypoglycemic ndi dipeptidyl peptidase-4 inhibitor (DPP-4).

Mankhwala

Alogliptin ndi zoletsa zamphamvu komanso zosankha kwambiri za DPP-4.

Kusankha kwake kwa DPP-4 ndizochulukirapo kuposa 10,000 masinthidwe ake pazinthu zina zokhudzana ndi michere, kuphatikiza DPP-8 ndi DPP-9.

DPP-4 ndiye puloteni yayikulu yomwe ikukhudzidwa pakuwonongeka kwadzidzidzi kwa mahomoni a banja la maretretin: glucagon-like peptide-1 (GLP-1) ndi glucose-wodalira insulinotropic polypeptide (HIP).

Mahomoni a banja la insretin amatulutsidwa m'matumbo, chidwi chawo chimawonjezeka poyankha kudya. GLP-1 ndi HIP zimawonjezera kaphatikizidwe ka insulin ndi katulutsidwe kake ka khungu la pancreatic beta. GLP-1 imalepheretsanso katulutsidwe wa glucagon ndikuchepetsa kupanga shuga wa chiwindi.

Chifukwa chake, kuchulukitsa kuchuluka kwa ma insretins, alogliptin kumakulitsa chitetezo chamatenda a glucose ndipo kumachepetsa kubisika kwa glucagon ndikuwonjezera kuchuluka kwa shuga m'magazi.

Odwala omwe ali ndi mtundu wachiwiri wa shuga wambiri ndi hyperglycemia, kusintha kumeneku kwa insulin ndi glucagon kumayambitsa kuchepa kwa ndende ya glycosylated hemoglobin HbA1c komanso kuchepa kwa kuchuluka kwa shuga m'magazi am'magazi a kusala komanso glucose ya postprandial.

Pharmacokinetics Ma pharmacokinetics a alogliptin ndi ofanana mwa anthu athanzi komanso odwala 2 a shuga.

Mtheradi bioavailability wa alogliptin pafupifupi 100%. Kugwiritsa ntchito mosakanikirana ndi zakudya zamafuta kwambiri sizinakhudze gawo lomwe lili ndi nthawi ya ndende (AUC) ya alogliptin, choncho imatha kuchitika mosasamala chakudyacho. Mwa anthu athanzi, pakapita pakamwa limodzi mpaka 800 mg ya alogliptin, kuyamwa mwachangu kwa mankhwalawa kumawonedwa ndikufika pazomwe zimapangitsa ambiri kuchuluka kwa ndende (a TCmax.) Pagawo kuyambira 1 mpaka 2 maola kuyambira nthawi yoyendetsa. Ngakhale odzipereka athanzi kapena odwala omwe ali ndi mtundu wa 2 mellitus sanawonetsere kwambiri kuchuluka kwa alogliptin atatha kubwereza. AUC ya alogliptin imachulukana motere ndi limodzi mlingo mu achire mlingo kuyambira 625 mg mpaka 100 mg. Kutheka kosiyanasiyana kwa AUC ya alogliptin pakati pa odwala ndi kochepa (17%). AUC (O-inf) ya alogliptin pambuyo pa limodzi mlingo wofanana ndi AUC (0-24) atamwa kumwa kamodzi patsiku kwa masiku 6. Izi zikuwonetsa kusakhalapo kwa kudalira kwa munetics ya alogliptin pambuyo pobwereza makonzedwe.

Pambuyo pakuwongolera kamodzi kwa alogliptin pa mlingo wa 12,5 mg mu odzipereka athanzi labwino, kuchuluka kwa magawo mu terminal anali 417 L, zomwe zikuwonetsa kuti alogliptin imagawidwa bwino mu minofu. Kuyankhulana ndi mapuloteni a plasma pafupifupi 20-30%.

Alogliptin samayikidwa mu metabolism yowonjezera, kuchokera ku 60 mpaka 70% ya alogliptin amachotsedwa osasinthika ndi impso.

Pambuyo pakuyang'anira kwa 14C-olembedwa alogliptin mkati, ma metabolites awiri akuluakulu adatsimikizika: N-demethylated alogliptin, M-I (50 mpaka 30 mpaka 1/100, 1/1000, 1/10 000,