Bacteria wamkati ndi chida chatsopano polimbana ndi matenda a shuga a 2

Mabakiteriya amkati amatha kuteteza ku matenda a shuga a mtundu wachiwiri. Izi zikuwonetsedwa ndi zotsatira za kafukufuku watsopano wopangidwa ku University of Eastern Finland.

High serum indolpropionic acid imateteza ku matenda ashuga a 2. Acid iyi ndi metabolite yopangidwa ndi mabakiteriya am'mimba ndipo zopangidwa zake zimapangidwira ndi chakudya chamafuta ambiri. Malinga ndi ofufuzawo, kupezako kumapereka chidziwitso chowonjezereka cha ntchito ya mabakiteriya amkati pakukhudzana pakati pa zakudya, kagayidwe kachakudya, komanso thanzi.

Phunziroli lidavumbulutsanso zingapo za lipid metabolites, kuchuluka kwake komwe kumalumikizidwa ndi kukana bwino kwa insulini komanso chiopsezo chochepetsa matenda a shuga. Kuzindikira kwa ma metabolites awa kumalumikizidwanso ndi mafuta azakudya: kutsitsa kuchuluka kwa mafuta m'magawo azakudya, kuchuluka kwambiri kwa metabolites awa. Monga indolpropionic acid, kutsika kwakukulu kwa ma lipid metabolites kumawonekeranso kuteteza kumatenda otsika.

"Kafukufuku wakale adalumikizanso mabakiteriya am'mimba ndi chiopsezo cha matenda kwa anthu onenepa kwambiri." Zotsatira zathu zikuwonetsa kuti indolepropionic acid ikhoza kukhala chimodzi mwazinthu zomwe zimathandizira kuti chitetezo chikhale cholimba komanso mabakiteriya am'mimba, "akutero katswiri wina wamaphunziro a Kati Hanhineva wa ku Yunivesite ya Eastern Finland.

Kuzindikiritsa mwachindunji mabakiteriya am'mimba ndi njira yovuta, chifukwa chake, kuzindikiritsa kwa metabolites opangidwa ndi mabakiteriya am'mimba kungakhale njira yoyenera kwambiri yowunikira ntchito ya mabakiteriya am'mimba mu pathogenesis ya, mwachitsanzo, matenda ashuga.

Bacteria wamkati komanso matenda ashuga

M'matumbo amunthu muli mabiliyoni mabacteria osiyanasiyana - ena abwino kwa thanzi lathu ndi ena oyipa. M'mbuyomu tinkakhulupirira kuti ndizofunikira pakugwirira ntchito kwam'mimba, koma malinga ndi zomwe zapezeka posachedwapa, mabakiteriya am'mimba amakhudza pafupifupi machitidwe onse a thupi lathu.

Zinadziwika kale kuti anthu omwe amadya fiber zambiri amakhala ndi mtundu wachiwiri wa matenda ashuga. Chakudya chopatsa thanzi mu michere chimathandizira kutsitsa shuga mwa anthu omwe ali ndi matenda ashuga kale. Komabe, kwa anthu osiyanasiyana, kuchuluka kwa zakudya zotere ndi kosiyana.

Posachedwa, a Liping Zhao, pulofesa ku G. Rutgers State University of New Jersey ku New Jersey, akhala akuphunzira za ubale pakati pa fiber, mabakiteriya am'mimba, komanso matenda ashuga. Anafuna kudziwa momwe chakudya chamafuta ambiri chimakhudzira matumbo ndikuchepetsa matendawa, ndipo njira imeneyi ikafotokozedwa, phunzirani zamomwe mungapangire kudya kwa anthu omwe ali ndi matenda a shuga a 2. Kumayambiriro kwa Marichi, zotsatira za kafukufukuyu wazaka 6 zidasindikizidwa munyuzipepala yaku America Science Science.

Mitundu yambiri ya mabakiteriya am'mimba amasintha ma carbohydrate kukhala mafuta amfupi achete, kuphatikizapo acetate, butyrate, ndi propionate. Mafuta acids awa amathandizira kulimbitsa maselo omwe amayenda matumbo, amachepetsa kutupa mkati mwake ndikuwongolera njala.

Asayansi adazindikira kale kulumikizana pakati pamagulu ochepa amafuta achilengedwe ndi shuga, mwa zina. Ophunzira a Professor Zhao adagawika m'magulu awiri ndikutsatira zakudya ziwiri zosiyana. Gulu limodzi lidatsata malangizo oyenera azakudya, ndipo enawo adalitsatira, koma pophatikiza kuchuluka kwa mitundu yambiri yazakudya, kuphatikiza tirigu wathunthu ndi mankhwala achikhalidwe achi China.

Kodi mabakiteriya ndi ofunikira?

Pambuyo pa kudya kwa milungu 12, omwe anali mgululi, momwe amatsindikizira anali CHIKWANGWANI, adachepetsa kwambiri kuchuluka kwa shuga m'magazi kwa miyezi itatu. Kuchulukitsa kwa glucose awo kunachepetsedwa mwachangu, ndipo adataya mapaundi ochulukirapo kuposa anthu omwe anali mgululi loyamba.

Kenako Dr. Zhao ndi ogwira nawo ntchito adayamba kudziwa kuti ndi mitundu yanji ya mabakiteriya yomwe ili ndi phindu lotere. Mwa mitundu 141 yama bakiteriya am'mimba omwe amatha kupanga mafupifupi amafuta acids, 15 okha amakula ndikugwiritsa ntchito ulusi wa cell. Chifukwa chake asayansi adazindikira kuti ndiko kukula kwawo komwe kumalumikizidwa ndi kusintha kwamphamvu m'thupi la odwala.

"Kafukufuku wathu akuwonetsa kuti ulusi wazomera womwe umadyetsa gulu la mabakiteriya amtunduwu umatha kukhala gawo lalikulu la chakudya komanso chithandizo cha anthu omwe ali ndi matenda a shuga a 2," akutero Dr. Zhao.

Mabakiteriyawa atakhala oimira kwambiri pamatumbo, adachulukitsa zamafupi amafuta amakanthawi a butrate ndi acetate. Izi zimapanga malo okhala acidic ambiri m'matumbo, zomwe zimachepetsa kuchuluka kwa mabakiteriya osafunikira, ndipo izi, zimabweretsa kuwonjezeka kwa kupanga kwa insulin ndikuwongolera bwino kuchuluka kwa shuga m'magazi.

Izi zatsopano zimayala maziko opanga zakudya zatsopano zomwe zimatha kuthandiza anthu omwe ali ndi matenda ashuga kuthana ndi vuto lawo kudzera mu chakudya. Njira yophweka koma yothandiza yolimbana ndi matendawa imatsegula chiyembekezo chodabwitsa cha kusintha kwa moyo wa odwala.

Asayansi ochokera ku Yunivesite ya Queensland Australia adalumikiza mabakiteriya am'mimba ndikupanga matenda amtundu wa shuga

Mwina odwala omwe ali ndi matenda a shuga 1 amatha kuthandizidwa ndikubwezeretsa kapangidwe ka microflora yamatumbo.

Monga momwe kafukufuku watsopano wasonyezera, kungoyang'ana kachilombo kakang'ono m'matumbo kungakhale njira imodzi yotetezera ku matenda ashuga a mtundu woyamba. Ofufuza ochokera ku Yunivesite ya Queensland ku Australia adapeza kusintha kwakukuru m'matumbo ndi anthu omwe ali pachiwopsezo chachikulu cha matenda a shuga 1.

Kuti mumve zambiri phunziroli, onani:

Zolemba Za Microbiome

Wolemba nawo kafukufuku Dr. Emma Hamilton-Williams wa Institute for Translational Study ku Yunivesite ya Queensland ndi anzawo akuti zomwe apeza zikuwonetsa kuti kutsata matumbo a microbiota kungakhale ndi mwayi wolepheretsa matenda ashuga amtundu woyamba.

MISRIKI YA MICROFLORA NDI MALO OYENETSA 2

Kasitomala samatulutsa insulin yokwanira, kapena insulin siyakonzedwa.

Mtundu wachiwiri wa matenda osokoneza bongo a shuga ndi matenda a metabolic omwe amadziwonetsa ngati kuphwanya kagayidwe kazachilengedwe. Thupi silipanga insulini yokwanira kugwira ntchito yoyenera, kapena maselo m'thupi samayankha insulin (insulin kukana kapena insulin kukana). Pafupifupi 90% ya anthu onse odwala matenda ashuga padziko lonse lapansi ali ndi matenda ashuga 2. Zotsatira zake za kupezeka kwa insulin kukana, ndiye kuti, chitetezo cha mthupi mthupi kupita ku timadzi timeneti, hyperglycemia imayamba (kuwonjezeka kwa kuchuluka kwa shuga m'magazi). M'mawu osavuta, thupi limakhala ndi insulini yokhazikika komanso kuchuluka kwa shuga, komwe pazifukwa zina sikungalowe m'maselo.

Asayansi atsimikizira gawo la micobiota pa insulin kukana mwakuwonjezera microflora kuchokera kwa wopereka wathanzi kupita kwa wodwala yemwe ali ndi matenda a shuga a 2. Chifukwa cha kuyesaku, odwala adakulitsa chidwi cha insulini mwa milungu ingapo.

Zambiri apa:

Pakalipano palibe amene akukayikira kuti kusintha kwachilengedwe komwe kumachitika m'thupi lathu ndipo kumatsimikizira thanzi lathu kumadalira mkhalidwe wam'mimba komanso momwe microflora yake imagwirira ntchito ndi maselo a thupi lathu. Popeza ma protein opanga ma immunomodulating katundu, amathandizira kuti mawonekedwe a microflora am'mimba atheretu, kuphatikiza Kuchepetsa thupi kulimbitsa thupi, zomwe zimawonjezera mwayi wokhala ndi matenda ashuga, kugwiritsa ntchito mwanthete mankhwala othandizira zakudya komanso kudya zakudya zapafupitirayi zitha kuganiziridwa kuti ndi njira imodzi yodalirika popewa komanso kuchiza matenda ashuga.

CHIFUKWA CHIYANI ZOSAVUTA ZINTHAUZA KUGWIRITSA NTCHITO KUGULITSA ZINSINSI

Mothandizidwa ndi microflora yamatumbo, CHIKWANGWANI chamafuta chimasinthidwa kukhala mafuta acid, omwe matumbo ake amagwiritsa ntchito kupangira shuga wawo. Yotsirizirayi imakhala chizindikiro ku ubongo kuti ndikofunikira kupondereza kumverera kwa njala, kuwonjezera kuchuluka kwa mphamvu zamagetsi ndikuchepetsa kumasulidwa kwa shuga ku chiwindi.

Munamvapo za zabwino za fiber, sichoncho? Pazakudya za fiber zomwe zimatiteteza ku kunenepa kwambiri komanso matenda ashuga. Ulusiwu umakhala ndi masamba ndi zipatso zambiri, koma matumbo enieniwo sangathe kuwagawa, chifukwa chake microflora imathamangira kukawathandiza. Mphamvu ya kagayidwe kazachilengedwe ndi kauthupi kazitsime imatsimikiziridwa ndi kuyesa kambiri: nyama pazakudya izi zomwe zinapeza mafuta ochepa, ndipo chiwopsezo chawo chokhala ndi matenda a shuga chinachepa. Komabe, sitinganene kuti timamvetsetsa bwino momwe ulusiwu umachitikira. Amadziwika kuti mabakiteriya am'mimba amawaphwanya ndikupanga ma fupi achete amafuta acid, propionic ndi butyric, omwe amamwetsedwa m'magazi. Asayansi ochokera ku National Center for Science Science (CNRS) ku France adanenanso kuti asidi mwanjira imeneyi amakhudza kapangidwe ka glucose m'matumbo. Maselo ake amatha kuphatikiza glucose, ndikuponyera m'magazi pakati pa chakudya ndi usiku. Izi ndizomwe zimafunikira: shuga amamangiriza ku portal vein receptors, omwe amatenga magazi kuchokera m'matumbo, ndipo izi zolandilira zimatumiza chizindikiro choyenera ku ubongo. Ubongo umayankha mwa kupondereza njala, kuwonjezera kuchuluka kwa mphamvu zomwe zimasungidwa ndikupangitsa chiwindi kuti chichepetse kupanga kwa glucose.

Ndiye kuti, chifukwa cha gawo laling'ono la glucose kuchokera m'matumbo, kumasulidwa kwa glucose ku chiwindi kumapanikizidwa, ndipo miyeso imatengedwa motsutsana ndi mayamwidwe atsopano - osafunikira komanso owopsa - zopatsa mphamvu.

Zinapezeka kuti ntchito ya majini omwe amapezeka m'matumbo am'mimba omwe amachititsa kuti glucose aphatikizidwe zimatengera ulusi womwewo, komanso ma propionic ndi butyric acid. Matumbo anali kugwiritsa ntchito propionic acid ngati zopangira popanga shuga. Impunga zomwe zimamwa mafuta ochulukirapo komanso mafuta ochulukirapo zimachepetsa kuchepa kwambiri ndipo zimawavuta kukhala ndi matenda ashuga ngati atadya fiber yokwanira ndi mafuta ndi shuga. Nthawi yomweyo, adakulitsa chidwi cha insulin (yomwe, monga mukudziwa, imachepera ndi matenda ashuga a 2).

Chidziwitso: Ndikofunika kuzindikira kutipropionic acidndiChimodzi mwazinthu zazikulu zotayira za mabakiteriya a propionic acid, omwe, pamodzi ndi propionates ndi propiocins, amatha kuletsa kukula kwa tizilombo toyambitsa matenda. Ndipo, mwachitsanzo, butyric acid amapangidwa ndi clostridia, omwe ali gawo la microflora wamba ya anthu.

Poyesanso kwina, mbewa zinagwiritsidwa ntchito momwe luso lopangira glucose m'matumbo linazimitsidwa. Pankhaniyi, kunalibe zopindulitsa mu fiber. Ndiye kuti, tcheni choterechi chikuwoneka: timadya michere, microflora imayendera mafuta acids, pomwe ma cell amatumbo angagwiritse ntchito kupangira shuga. Gluuyu amafunikira kuti muchepetse kufuna kwathu kosayenera kutafuna kanthu usiku, komanso kuti shuga azikhala moyenerera m'thupi.

Kumbali ina, iyi ndi mfundo ina yotsimikizira kuti timafunikira microflora yamatumbo kuti tikhala athanzi, ndipo mkanganowu wapeza makina amomwe amachititsa kuti pakhale michere yambiri. Kumbali ina, ndizotheka, mothandizidwa ndi unyolo wamitundu iyi, ndizotheka mtsogolomo kupondereza njira zosayenera zomwe zingatipangitse kunenepa kwambiri komanso matenda a shuga. / Zotsatira za kafukufukuyu zalembedwa mu Cell Cell.

* Kuti mugwiritse ntchito mphamvu za tizilombo tating'onoting'ono topanga mankhwala popanga mankhwala opangira mankhwalawa komanso kupewa matenda a shuga, onani tanthauzo la "Bifikardio" wofufuza:

Khalani athanzi!

ZOCHITITSAZOKHUDZA MALO OTSOGOLA

Ndingatani?

Pakadali pano, mutha kuyang'ana zakudya zanu zomwe mungakambirane ndi dokotala momwe mungawonjezere ndi fiber. Zakudya zomwe zimaloledwa kukhala ndi matenda ashuga komanso olemera mu fiber zimaphatikizapo, mwachitsanzo: raspberries, kabichi yoyera yatsopano, zitsamba zatsopano, kaloti watsopano, dzungu lotentha ndi ma Spussels, avocados, buckwheat, oatmeal. Ndi zochepa, mutha kudya mtedza, ma almond, pistachios (wopanda mchere ndi shuga,), komanso mphodza ndi nyemba, ndipo, mkate wopanda tirigu wochokera ku malemeal ndi chinangwa.