Zotsatira za shuga za Chlorhexidine 0,05

Chlorhexidine - mankhwala, antiseptic, mu mitundu yomaliza ya mankhwalawa amagwiritsidwa ntchito ngati njira yayikulu ya gluluconate (Chlorhexidini bigluconas). Chlorhexidine wagwiritsa ntchito bwino ngati mankhwala antiseptic ndi mankhwala opha tizilombo kwa zaka zopitilira 60.

0,05% yankho lamadzi mu Mbale 100 ml.

0,5% yankho la zakumwa zakumwa 100 ml.

Chlorhexidine


Pake wa mankhwala
IUPAC	N ',N '' '' '-hexane-1,6-diylbisN- (4-chlorophenyl) (imidodicarbonimidic diamide)
Choyimira chokha	C₂₂H₃₀Cl₂N₁₀
Unyinji wa Molar	505.446 g / mol
Cas	55-56-1
PubChem	5353524
Drugbank	APRD00545
Gulu
ATX	A01AB03 B05CA02, D08AC02, D09AA12, R02AA05, S01AX09, S02AA09, S03AA04
Mlingo Wamitundu
Njira zoyendetsera
Mafuta oyambira d
Mayina ena
"Sebidin", "Amident", "Hexicon", "Chlorhexidine bigluconate"
Wikimedia Commons Media Mafayilo

Ndikofunikira kudziwa kuti nthawi yonse yogwiritsira ntchito malonda ndi kafukufuku wa sayansi wa chlorhexidine, palibe m'modzi yemwe angatsimikizire motsimikiza kuti kupangidwa kwa tizilombo toyambitsa matenda a chlorhexidine. Komabe, malinga ndi kafukufuku waposachedwa, kugwiritsa ntchito chlorhexidine kungayambitse kukana kwa mabakiteriya (makamaka, kukana kwa Klebsiella pneumoniae kupita ku Colistin).

Mwamwambo, ndi dichloro yomwe imachokera ku biguanide. Kapangidwe kamayandikira kwambiri ndi mainumal. Njira yogwiritsira ntchito chlorhexidine imalumikizana ndi magulu a phosphate pamwamba pa khungu, zomwe zimapangitsa kuti kusuntha kwamlingo wa osmotic, kuphwanya umphumphu wa khungu ndi kufa kwake.

Chlorhexidine ndi mankhwala antiseptic omwe amagwira ntchito motsutsana ndi gramu-gram komanso negative aerobic ndi anaerobic bacteria (Treponema pall>. Mankhwala ndi okhazikika ndipo atatha kukonza khungu (manja, malo opangira opaleshoni, ndi zina) amakhalabe pamtunda wina, womwe umapitilizabe kupatsanso bactericidal.

Mankhwala amakhalabe amagwira pamaso pa magazi, mafinya, ngakhale atachepa. Mitundu ina ya Pseudomonas spp., Proteus spp. Amakhala osalimba ndi chlorhexidine, mitundu yolimbana ndi mabakiteriya imalephera. Chlorhexidine amagwira mabakiteriya okhazikika pazotentha zokhazokha.

Amagwiritsidwa ntchito pochiza malo opangira opaleshoni ndi manja a dokotala wa opaleshoni, zida zopangira maantibayotiki, komanso njira zoyeretsa (kutsuka mabala opaleshoni, chikhodzodzo, ndi zina) komanso kupewa matenda opatsirana pogonana (syphilis, gonorrhea, trichomoniasis). Thupi la chlorhexidine bigluconate limapezeka ngati yankho la 20% lamadzi. Mankhwala omwe mwakonzeka kugwiritsa ntchito ndi njira yokhayo yowonjezera madzi kapena hydroalcoholic. Chifukwa chake, pokonzekera malo opangira opaleshoni, yankho la 20% limapukusidwa ndi 70% ethyl mowa mu chiyerekezo cha 1:40. Zotsatira 0,5% zamadzimadzi zakumwa zoledzeretsa za chlorhexidine bigluconate zimathandizidwa ndi opaleshoniyo munda 2 kawiri pakadutsa mphindi ziwiri. Kugwiritsa ntchito zida zothimbirira mwachangu, gwiritsani ntchito njira yomweyo kwa mphindi 5. Yankho lamadzi 0,5% limagwiritsidwa ntchito kupukuta mabala ndikuwotcha, yankho la mowa la 0.5% kapena yankho lamadzi 1% imagwiritsidwa ntchito kupukutira m'manja. Mukamagwiritsa ntchito mankhwalawa kuthana ndi manja a dokotala wa opaleshoni, zimapangitsa kuti ziume komanso khungu, dermatitis, khungu la manja mkati mwa mphindi 3-5 ndizothekanso.

suppository imodzi ili ndi 0,016 g ya chlorhexidine bigluconate

Vaginal suppositories (mawonekedwe a makanda)

suppository imodzi ili ndi 0,008 g wa chlorhexidine bigluconate.
Mafuta ogwiritsa ntchito kunja ndi kunja kwa 0,5% (100 ga gel osakaniza ali ndi 0,5 g ya chlorhexidine bigluconate).
Njira yothetsera kunja kwa 0.05% (100 ml ya madzi oyeretsedwa ili ndi yankho la chlorhexidine bigluconate 20% - 0,25 ml).

Malangizo a rinsing pamlomo wamkati:

0,2% yankho lamadzi
0.1% yankho la chlorhexidine bigluconate mu ethanol (Eludryl).

Chlorhexidine monga prophylactic ndi achire othandizira amagwiritsidwa ntchito mopindulitsa. 0,05%, 0,2% ndi 0,5% yamadzi mayendedwe amagwiritsidwa ntchito ngati kuthirira, kutsanulira ndi kugwiritsa ntchito - 5-10 ml ya yankho limagwiritsidwa ntchito pokhudzidwa ndi khungu kapena mucous nembanemba ndi mphindi 1-3 2-3 patsiku (pa swab kapena kuthilira). Kupanga zida zamankhwala ndi mawonekedwe a ntchito ikuchitika ndi chinkhupule choyera chovinikidwa ndi yankho la antiseptic, kapena ndikuwuluka. Popewa matenda opatsirana pogonana, mankhwalawa amagwira ntchito ngati sagwiritsidwa ntchito patadutsa maola awiri atagonana. Kugwiritsa ntchito mphuno, ikani zamkati mwa urethra kwa amuna (2-3 ml), akazi (1-2 ml) ndi mu nyini (5-10 ml) kwa mphindi 2-3. Kusintha khungu la mkati mwa ntchafu, tsitsi, kumaliseche. Pambuyo pa njirayi, musati mupeze kukonzekera kwa maola awiri. Intravaginally, 1 supplementory katatu patsiku kwa masiku 7-20, kutengera mtundu wa matendawa. Chokocha ndi gel osakaniza pamwambo wapafupipafupi nthawi zambiri zimaperekedwa katatu patsiku. Paka: chotsani filimu yoteteza pamalo popewa osakhudza bandeji ndi zala zanu, ndikuyika pamalo owonongeka a khungu. Kanikizani m'mbali mwa chigamba ndi zala zanu kuti mbali yolumikizayo ikonzeke.

Mu 2013, WHO idaphatikizapo yankho la 7% ya chlorhexidine bigluconate pamndandanda wamankhwala ofunikira. Malinga ndi malingaliro a WHO, chingwe cha ma umbilical (chiwopsezo cha umbilical) chimathandizidwa ndi yankho la 7%, chomwe chimachepetsa mwayi wokhala ndi kachilombo mwa akhanda.

Chithandizo cha matenda amkazi (bakiteriya vaginosis, trichomoniasis, osalunjika, matenda osakanikirana)
mwadzidzidzi kupewa matenda opatsirana pogonana (syphilis, gonorrhea, trichomoniasis, chlamydia, ureaplasmosis)
kukonzanso ngalande yakubadwa kukonzekera kubereka ndi kuyang'anira nthawi yobereka itatha azimayi omwe ali pachiwopsezo cha matenda opatsirana komanso otupa

Vaginal suppositories angagwiritsidwe ntchito onse trimesters wa mimba ndi mkaka wa m`mawere. Vaginal suppositories mokoma amakhudza mucous nembanemba, kwinaku akukhalabe wabwinobwino microflora. gwero silinatchulidwe masiku 3375

Vaginal suppositories (mawonekedwe a makanda)

Gel wa ntchito wamba ndi kunja kwa 0,5%

mankhwalawa mabala, abrasions, mikwingwirima, kuwotcha, zipsera
Chithandizo ndi kupewa matenda a pakhungu ndi mucous nembanemba
ntchito mano (gingivitis, stomatitis ndi periodontitis)
mankhwala a ziphuphu zakumaso (monga gawo la zovuta mankhwala)
kusamalira khungu pambuyo pochita zodzikongoletsera (kuboola, kujambula, kuchotsa)
kutetezedwa ku ma virus pa malo a anthu, mwachilengedwe
0,5% mowa yankho la chlorhexidine

chithandizo chamanja cha ogwira ntchito zachipatala, madokotala a opaleshoni, chithandizo cha khungu pamalo ogwiritsira ntchito ndi jakisoni
mankhwala a mabala opaleshoni ndi kukhudzana kwa mphindi 1-2
kusazindikira zida zamankhwala, zida zamano, mawonekedwe a mawonekedwe a zida
0,05% yamchere yankho la chlorhexidine bigluconate

kuchapa mabala, kuphwanya zilonda, kuwotcha, kuwaza, kuluma tizilombo
ntchito mano (gingivitis, stomatitis, alveolitis, periodontitis)
Chithandizo cha matenda a ENT (pharyngitis, laryngitis, tonsillitis, otitis media)
kutetezedwa ku ma virus pa malo a anthu, mwachilengedwe
kupewa matenda opatsirana pogonana
0,2% madzi amchere a chlorhexidine bigluconate

mankhwalawa ndikukonzanso kwamtundu wa kumaliseche, matenda a urology panthawi yazachipatala
disinication wa zochotsa mano
0,5% yamchere yankho la chlorhexidine bigluconate

mankhwalawa mabala ndi kuwotcha, mankhwalawa matenda oyambitsidwa ndi ming'alu ya pakhungu, zotseguka
Chowiritsa chida chachipatala pamtunda wa 70 ° C
1% yankho lamadzimadzi a chlorhexidine bigluconate

zoteteza ku matenda a zipinda, zida zaukhondo, ndi zina zambiri.
Chithandizo cha malo opangira opaleshoni ndi manja a dokotala wa opereshoni musanachite opareshoni, kuteteza khungu, chithandizo cha postoperative ndi mabala owotcha
Hypersensitivity kwa mankhwala, dermatitis, thupi lawo siligwirizana. Kugwiritsa ntchito iodine munthawi yomweyo sikothandiza kuti muchepetse dermatitis. Mankhwala a Chlorhexidine sayenera kugwiritsidwa ntchito pochiza matenda a conjunctiva komanso kutsuka malowo.
Chenjezo Kusintha
Gwiritsani ntchito mosamala muubwana.
Chlorhexidine amagwiritsidwa ntchito poletsa matenda opatsirana pogonana pokhapokha ngati njira yodzidzimutsira (kuphulika kwa kondomu, kugonana mwangozi). Kukhazikika pafupipafupi komanso mobwerezabwereza kwa chlorhexidine mu urethra kumatha kuyambitsa kutentha kwa mankhwala (makamaka ndi hypersensitivity ya mankhwala), zomwe pamapeto pake zingayambitse vuto lalikulu monga urethral solidation gwero silinatchulidwe masiku 1142 .
Vaginal Suppositories. Thupi lawo siligwirizana, kuyabwa, kumachitika pambuyo kusiya mankhwala ndikotheka. Kutha kwa magazi mwamphamvu zosiyanasiyana ndizotheka.
Gel. Thupi lawo siligwirizana, khungu louma, kuyabwa, kusokonezeka kwa khungu, dermatitis, khungu la manja Mankhwalawa gingivitis - madontho a mano enamel, tartar mafunsidwe, kukoma chisokonezo. Enamel madontho ndi kuwerengera masanjidwe zimachitika ngati ntchito kwa nthawi yayitali.
Njira Zothetsera. Si kawirikawiri zomwe zimayambitsa kuyanjana, kuyabwa, kudutsa mankhwala atatha.
Ngati mwalowa mwangozi mankhwala, samakomoka; chapamimba pake pamakhala mkaka, sopo wofatsa, gelatin kapena dzira laiwisi.
Palibe mankhwalawa enieni, motero, ngati mukuyambitsa mavuto, chizindikiro cha chithandizo chimachitika.

Kugwiritsa ntchito poyanjana ndi ayodini sikulimbikitsidwa.
Chlorhexidine sagwirizana ndi zotsekemera zomwe zimakhala ndi anionic gulu (saponins, sodium lauryl sulfate, sulfonic acid, sodium carboxymethyl cellulose) ndi sopo. Kupezeka kwa sopo kungapangitse chlorhexidine, ndiye kuti zotsalazo zimatsukidwa musanayambe kugwiritsa ntchito mankhwalawa.
Amakhala popanga poizoni akaphatikizidwa ndi sodium hypochlorite (NaOCl) - para-chloraniline (n-NH₂C₆H₄Cl). Pali umboni kuti parachloraniline ndi poizoni (Burkhardt-Holm et al., 1999) maulalo osakwanira ndipo zingayambitse kupanga kwa methemoglobin.
Ethanol imawonjezera mphamvu ya chlorhexidine.

Ma suppositories anyama. Kunja kwamtundu wamunthu sikukhudza kugwira ntchito ndi kulolerana kwa zowonjezera kumaliseche, popeza mankhwalawa amagwiritsidwa ntchito kudzera m'mitsempha.
Yothetsera ndi gel. Pewani kulowa mankhwalawa m'mabala a odwala omwe ali ndi vuto lovulala la craniocerebral, kuvulala kwa msana, kukonza kwa membrane wa tympanic. Ngati yankho likulowa mucous nembanemba wa diso, ayenera kutsukidwa mwachangu ndi madzi. Ma Safe Data Sheets (MSDS) a chlorhexidine bigluconate.
Kuphatikizika kwa zinthu zoyera za hypochlorite pazinthu zomwe kale zinali kulumikizana ndi chlorhexidine okhala ndi kukonzekera kungapangitse kuti mawanga a bulauni awonekere. Mphamvu ya bactericidal imachulukirachulukira ndikuwonjezera kutentha kwa yankho. Pamatenthedwe opitilira 100 ° C, mankhwalawo amawola pang'ono.
Njira zothetsera zamchere za chlorhexidine zimatha kuwola (makamaka mkaka ndi zamchere pH) ndi mapangidwe a 4-chloroaniline, omwe ali ndi katundu wamthupi.
Nkhani yofotokozedwa pati? kukula kwa methemoglobinemia ndi cyanosis mwa ana osakhazikika mu chofungatira chifukwa cha 4-chloroaniline poyizoni gwero silinatchulidwe masiku 284 . Chofungatira chake chinali ndi chinyezi chokhala ndi yankho la chlorhexidine, chomwe, chikatentha, chimatha kuwola 4-chloroaniline.