Ubwino wa Omez kapena Pariet ndi kapamba?

Ndipo nali lingaliro langa ponena za mankhwalawa. Ma PPI onsewa amachotsa 100% acid ngati 40 mg atengedwa. Ndipo asankhe. Ndipo kawirikawiri mu theka. Koma ngakhale muyezo wa theka, amachedwa mwachangu komanso kosatha acidity, panthawi chabe. Ndipo ndichifukwa chiyani ndili ndi mantha kuti n`koyipa kumwa mankhwala ngati awa ndipo, zikuwoneka kwa ine, zimatsanulira, ngati pakufunika thandizo, mutha kuyendetsa msuzi wamatumbo pamlingo wotere. Chifukwa chake, ndimamwa mankhwala ochepetsa mphamvu: Famotidine, ranitidine. Ndizowopsa kwa TM, kuti pali rebound syndrome nthawi yakutha, koma apa ... ndiyodi, ndipo PPI ikunena kuti sichoncho. Ngakhale zili choncho, koma osati kuchokera ku Cannon pa mpheta. Chinthu chimodzi mwadzidzidzi kapena njira yayifupi. Ndipo ngati kuponderezedwa kwa asidi kumakhala kofunikira kawirikawiri chifukwa acidity imachuluka?

Pali lingaliro la madokotala. Mankhwala amafunikira, mwachangu komanso opanga .. monga momwe zimakhalira .. mphotho .. awa ndi malingaliro anga, atha kukhala olakwika. Koma sindikufuna mphamvu za kuponderezedwa kwa asidi awa, pomwe mankhwala opanda mphamvu amathandiza.

Mankhwala

Kuphatikizidwa kwa Omez kumaphatikizira yogwira mankhwala omeprazole, yomwe imachepetsa kupanga kwa hydrochloric acid m'mimba ndikusokoneza Helicobacter, bacterium yomwe imakwiyitsa zilonda zam'mimba. Mankhwalawa amagwira ntchito masana, bioavailability (degree of assimilation) yomwe imakhala ndi mlingo umodzi osapitilira 40%.
Chithandizo chogwira ntchito ku Pariet ndi rabeprazole. Zimalepheretsanso kupanga asidi mwa maselo a mkati mwa m'mimba, koma sizikhudza Helicobacter. Kutalika kwa achire zotsatira za rabeprazole kumatha kufika masiku 2, ndipo bioavailability ndi 52%.

kupezeka kwa zilonda ndi kukokoloka kwa m'mimba kapena duodenum, mosayang'ana komwe adachokera,
gastroesophageal Reflux matenda - GERD (kuwonongeka kwa khoma pachiwindi chifukwa cha kukwiya kwa asidi pambuyo pobwerera m'mimba),
Zollinger-Ellison syndrome - chikhodzodzo cha kapamba chomwe chimapanga michere, yomwe imalimbikitsa mapangidwe a asidi.
kutupa kwa m'mimba (gastritis), kukwiya chifukwa cha zochepa za pH zamadzimadzi am'mimba,
kupewa asidi kutentha m'mimba ya kupuma thirakiti (Mendelssohn syndrome),
Zizindikiro za kuphwanya kwa gastric siteji ya chimbudzi - nseru, kutentha pa chifuwa, kupindika, kupweteka.

kukokoloka pachimake ndi zilonda zam'mimba m'makoma am'mimba kapena duodenum, kuphatikizapo omwe amayamba ndi helicobacter - bacterium yomwe imakwiyitsa zilonda zam'mimba,
chilonda m'mimba,
GERD,
Zollinger-Ellison syndrome.

Contraindication

kusalolera pakumwa mankhwala,
kugwiritsa ntchito munthawi yomweyo mankhwala angapo omwe amathandizika pochiza zotupa, fungal ndi matenda a virus,
zaka zosakwana ana 2.

Hypersensitivity pamagawo a mankhwala,
nthawi ya bere ndi kuyamwitsa,
ana ochepera zaka 12.

Zotsatira zoyipa

chifuwa
nkhawa ndi kukhumudwa, mavuto atulo,
kutsitsa kaonedwe, kaimidwe ndi kakomedwe,
chizungulire, kupweteka mutu,
kuyerekezera
kuchepa kwa ndende yamagazi onse,
kusokoneza chiwindi,
kuuma ndi kutulutsa kwamkati pamkamwa,
phokoso lokwiyitsa, kupweteka pamimba, kusefukira,
kusanza, kusanza,
kupweteka minofu ndi mafupa.

ziwengo
kudzimbidwa,
kuyanika kuchokera kumkamwa,
jaundice
kupweteka m'mimba, kugona mosatekeseka,
mutu, chizungulire,
kukakamira kapangidwe ka magazi m'magazi,
Kuchulukitsa kwa anthu m'mawere,
kupweteka m'malo.

Kutulutsa mawonekedwe ndi mtengo

10 mg makapisozi, ma PC 10. - 77 ma ruble.,
zisoti. 20 mg, 30 ma PC. - 148 rub.,
zisoti. 40 mg, 40 ma PC. - 275 rub.,
sungunuka lyophilisate 40 mg, 1 botolo - 164 ma ruble.,
Omez Insta, ufa, 20 mg, ma sache 5 - 80 rub.,
Omez DSR, zisoti. 30 + 20 mg, 30 ma PC. - 408 rub.,
Omez D, zisoti. 10 + 10 mg, 30 ma PC. - 322 rub.

Mapiritsi 10 mg, 14 ma PC. - 1079 rub.,
tabu. 10 mg, 7 ma PC. - 986 rub.,
tabu. 20 mg, 14 ma PC. - 2049 rub.,
tabu. 20 mg, 28 ma PC. - 4047 rub.

Zizindikiro zogwiritsidwa ntchito

Pariet amagwiritsidwa ntchito pochiza:

Reflux esophagitis,
zilonda zam'mimba,
zilonda zam'mimba,
Zollinger-Ellison syndrome yokhudzana ndi chotupa cha kapangidwe kake ka kapamba (kapamba) wotulutsa kondakitala wa hydrochloric acid - gastrin,
aakulu gastritis.

Kuphatikiza ndi maantibayotiki, Pariet amagwiritsidwa ntchito pochotsa (antibacterial) mankhwala a Helicobacter Pylori. Chida ichi ndi choyenera kuchiritsira kwa nthawi yayitali cha Reflux.

Mlingo ndi makonzedwe

Pariet imalembedwa kwa akuluakulu kutengera mkhalidwe wawo wakuthupi. Maphunzirowa ndi muyezo womwe akuwonetsedwa mu malangizo a wopanga ndi awa:

Zilonda za Duodenal ndi zilonda zam'mimba mu gawo logwira: 20 mg kamodzi patsiku, m'mawa. Maphunzirowa amayambira milungu iwiri mpaka mwezi umodzi.
Reflux esophagitis: 20 mg kamodzi tsiku lililonse. Maphunzirowa ndi miyezi 1-2.
Kuchotsa (kuthetsa) kwa H. pylori: 20 mg kawiri pa tsiku kwa sabata limodzi ndi Clarithromycin ndi Amoxicillin.
Ndi mawonekedwe osakhazikika a kutupa kwa kapamba, Pariet (20 mg) amamuika m'mawa mphindi 30 asanadye chakudya cham'mawa. Maphunzirowa ndi milungu 4. Dokotala angasinthe mlingo ndi nthawi.

Tengani piritsi lonse, osafuna kutafuna, ndi madzi okwanira.

Pariet ali ndi katundu wamchere pang'ono. Mlingo woyenera, umalowa mwachangu ndipo umayamba kugwira ntchito mu ola limodzi, kudziunjikira maselo a parietal.

Zotsatira zoyipa

Zotsatira zoyipa zomwe zidawoneka pa maphunziro zinali zazifupi ndipo zidafotokozedwa ngati:

Pafupifupi 2% ya zochitikazo zinali zapakhomo: rhinitis, flatulence, pharyngitis, kusanza, kupweteka kwammbuyo, kusamva bwino, kudzimbidwa komanso kusowa tulo. Osakwana 1% ya odwala omwe amatenga Pariet adadandaula kuti myalgia, kupweteka kwapakati, pakamwa pouma, kugona, kukomoka, kukwiya, zina.

Poganizira mtundu wamtunduwu wa mawonekedwe awa, zimadziwika kuti Pariet sikukhudza kuyendetsa. Komabe, ndi kuwodzera (mbali yayitali), simuyenera kuyendetsa ndikugwira ntchito ndi zovuta kupanga.

Kuchita ndi mankhwala ena

Kuwunikira kofananira kwa sodium ya rabeprazole ndi Warfarin, Phenytoin, Theophylline, Diazepam sanawonetse mgwirizano wofunikira mothandizidwa ndi matenda. Zambiri zolemba zamankhwala zimawonetsa kulolerana kwa Pariet ndi kukonzekera kwa antacid.

Koma kudya kwake kumakhudzanso kuyamwa kwa vitamini B12, kuchepetsa kuyamwa kwake. Kuphatikizika kwa mankhwalawa ndi Ketoconazole kapena Itraconazole kumapangitsa kutsika kwazomwe zili m'madzi a m'magazi, komanso kuyanjana ndi Digoxin, m'malo mwake, kumakulitsa kuchuluka kwake. Kuvomerezeka kwa mankhwalawa ndi Pariet kuyenera kuchitika moyang'aniridwa ndi adokotala.

Madokotala amachenjeza za zoopsa zomwe zingaphatikizidwe ndi mankhwalawa ndi zakumwa zoledzeretsa, popeza kuyanjana ndi mowa wa rabeprazole sodium sikunaphunzire bwino.

Kupanga ndi mawonekedwe a kumasulidwa

Pariet amathandizira kuletsa ntchito za enzyme (proton pump) ya ATPase H + / K +, kupanga hydrochloric acid.

The yogwira Pariet ndi rabeprazole sodium, benzimidazole zotumphukira gulu la proton pump zoletsa. Mapiritsi 10 kapena 20 mg mulinso: mannitol, magnesium oxide, hydroxypropylcellulose, magnesium stearate, ethylcellulose, talc, titanium dioxide, iron oxide chikasu, iron oxide wofiira ndi sera wa carnauba.

Pariet imapangidwa ngati mapiritsi okhala ndi interic m'matumba a 7 kapena 14 ma PC.

10 mg - pinki, biconvex, wokutira, mbali imodzi yakuda chizindikiro "E241",
20 mg - wachikasu wachikasu, biconvex, wokutira, wokhala ndi chizindikiro chofiira "E243".

Timatumba tadzaza timabokosi tating'ono.

Mimba komanso kuyamwa

Chidziwitso chodalirika chamankhwala chamankhwala omwe amupatsa panthawi ya gestation kulibe. Chifukwa chake, pakakhala pakati, Pariet imatsutsana.

Zotsatira zakulowa kwa rabeprazole sodium mumkaka wa amayi oyamwitsa sizinaphunzire. Madokotala amalephera kugwiritsa ntchito mankhwalawa poyamwitsa.

Mankhwala Okhala Pamalo a Pharmacy

Dokotala amafunikira kugula mankhwalawa. Mankhwala angapo, amangofunikira pokhapokha kugula Parieta mu 20 mg.

Omeprazole wa kapamba: malangizo ogwiritsira ntchito
Pancreatitis Nolpase Mapale
Momwe mungatenge Nexium pancreatitis?
Mexicoidol wa kapamba

Madokotala omwe achulukitsa ziphuphu zakumaso zomwe amakonda kukhazikika, michere ndi ma pinkiller. Pariete adasankhidwa koyamba mwezi wapitawu, ululuwo utangowazunza. Sindinkaganiza kuti mankhwalawo angathandize kuwachotsa mwachangu. Amangokhala ndi ntchito yosiyana - kuchepetsa kubisalira komanso kuchepetsa kukakamiza mu ma pancreatic ducts. Ndipo kuchuluka kwa kukakamiza ndi komwe kudandipweteketsa.

Ndikosavuta kutsimikiza kwa ena zomwe mumavomereza. Omeprazole wodziwika bwino amathandiza ndi burging wa asidi, kutentha kwa mtima ndi kupweteka. Koma Pariet adakopa kuthamanga ndi zotsatira zoyipa zochepa, ngakhale anali okwera mtengo. Ndimamwa monga adanenera adokotala kwa masabata awiri miyezi isanu ndi umodzi iliyonse. Ndikhulupirira kuti kusankha kuyenera kuchitidwa moyenera, osati motchipa.

Tsambali limagwiritsa ntchito Akismet kulimbana ndi sipamu. Dziwani momwe malingaliro anu amapangidwira.

Kodi pariet imagwiritsidwa ntchito bwanji?

Chochita chachikulu ndikuchepetsa acidity yam'mimba, yomwe imathandizanso kuchira. Mphamvu ya analgesic imathandizira kumva kupumula mu mphindi zochepa.

Ngakhale kugwiritsidwa ntchito bwino kwa mankhwalawa, anthu nthawi zambiri amafunafuna ma analogi, chifukwa mtengo wa mankhwalawa ku Russia ndi wochokera ku ma ruble 780.

Kutulutsa mawonekedwe - mapiritsi ozungulira mu chipolopolo. Zochita zake zimachitika mwachangu kwambiri kuposa za Omez.

Kuwuluka kumathandiza kwambiri kutentha. Mankhwalawa amagwirizana ndi mankhwala ena a antibacterial omwe cholinga chake ndi kuthetseratu kachilomboka m'mimba. Kuphatikiza apo, kusakhalako kwathunthu kwa zoyipa kumamupangitsa kukhala mtsogoleri pakati pa mankhwala ofanana.

Contraindication kuti agwiritse ntchito akhoza kukhala motere:

Kuletsa kumwa mankhwalawa kwa ana osakwana zaka 12.
Kulephera kwamankhwala kumapangitsa kuti mankhwala asamachitike.
Sizoletsedwa kusankha komanso kuwonjezera kuchuluka kwanu.
Kusavomerezeka ndi thupi la zigawo zina za mankhwalawo.
Mimba komanso kuyamwa ndi nthawi zomwe sizingatengedwe Pariet.

Kuvulaza kwa mfundo yomaliza sikumatsimikiziridwa ndendende, koma ndikudziwika kuti zigawo za mankhwala zimadutsa mkaka wa m'mawere kupita kwa mwana.

Malingaliro a akatswiri pankhani ya Pariet ndi abwino okha, chifukwa adatsimikiziridwa kuti ali ndi kuthekera kochotsa ziwalo m'thupi kuti muchepetse kagayidwe. Ngati mankhwala osokoneza bongo, kufunika koti muzimutsuka m'mimba. Zilibe zotsatira zolimba, chifukwa chake zimaloledwa mosavuta ndi thupi.

Zilibe mphamvu zowononga mthupi lonse. Mukamagwiritsa ntchito mapiritsi, sayenera kutafunidwa. Amamwa m'mawa asanadye.

Pazonse, mankhwala amaloledwa nthawi iliyonse, koma m'mawa zotsatira zake zimakhala zamphamvu kwambiri. Ngakhale mawonekedwe abwino, ali ndi zovuta zochepa. Mukachulukitsa kuchuluka kwa mapiritsiwo, ndiye kuti calcium imachotsedwa m'thupi, zomwe zimapangitsa kuti mafupa awonongeke. Chifukwa chake, kudzipereka nokha ndi chida ichi nkoletsedwa. Mankhwalawa ali ndi ndemanga zopitilira umodzi, ngakhale zili pamtengo wokwera.

Akagwiritsidwa ntchito, wodwalayo amatha kukumana ndi mavuto.

Izi zikuphatikiza:

kutsegula m'mimba
kudzimbidwa
kufooka
nseru
kamwa yowuma
zotupa pakhungu.

Pariet samatengedwa ndi mapiritsi omwe amachepetsa acidity yam'mimba.

Chithandizo choyamba cham'mimba

M'mphindi zoyambirira zowoneka ngati zowawa pamimba, ndikofunikira kuyimitsa chisangalalo chosangalatsa. Chifukwa cha izi, ma painkiller amagwiritsidwa ntchito. Kuphatikiza apo, ndibwino kusiya kudya chakudya kwanthawi yoyamba, m'malo momangodya chakumwa chachikulu kapena msuzi wamafuta ochepa. Nthawi zina, njira zina zingathandize, mwachitsanzo:

Ndi kuchulukana kwa gastritis, madokotala amalimbikitsa kukhala pamalo apamwamba m'mbali mwanu ndi mawondo anu. Kuti muchite bwino, mutha kuyika pamimba panu yozizira kapena kupukusa pamimba. Pankhani yamavuto, ndikofunikira kumwa madzi ndikusanza.
Pokhala ndi zizindikiro za poyizoni, makala okhazikika ndi ma sorby ena amathandizira kuthetsa chisokonezo. Kenako muyenera kubwezeretsa madzi mthupi ndi zakumwa zambiri.

Zomwe mungamwe ndi kupweteka m'mimba ngati chithandizo chitha kungosankhidwa ndi dokotala. Amanenanso kuti athetse mankhwalawa ndi njira yomwe amamwa mankhwalawo. Komabe, pali zochitika zina pomwe sizingatheke kuonana ndi katswiri, ndiye muyenera kusankha mankhwalawa malinga ndi zomwe mukuwonetsa:

Ndi gastritis kapena chilonda chokhala ndi acidity yam'mimba, acid belching ndikuwotcha, izi zikuthandizira: Gastral, Anacid, De-nol, Flacarbin, Almagel.
Ngati kusasangalala kumayambitsidwa ndi kudya kosayenera, kudya kwambiri komanso zinthu zina, tengani: Gastromax, Mezim, Omeprazole, Cimetidine.
Zimathandizira kutsitsa kukokana m'mimba: No-shpa, Besalol, Buscopan.
Kuyambira kudzimbidwa ndi gastritis yotsika acidity, madokotala amalembera: Festal, Tritorment, Panzinorm, Creon.

Mosasamala zomwe zimayambitsa kukokana, mankhwala amayenera kuchitika nthawi zonse molumikizana ndi zakudya zoyenera. Kwa nthawi yoyamba, muyenera kukana chakudya chokwanira, mpaka mavuto atatsika. Kenako amadya patebulo la zakudya zoletsedwa:

Mapiritsi a Nexium 20 mg ndi 40 mg

Ndi GERD ndi esophagitis, Nexium iyenera kumwa 40 mg kamodzi patsiku kwa masabata anayi. Ngati, atatha maphunziro, kuchiritsa kwathunthu sikunachitike kapena zizindikiro za matendawa zikupitilira, ndiye kuti Nexium 40 mg ayenera kumwedwa popanda kupuma kamodzi patsiku kwa masabata ena anayi.

Mankhwala okonza pambuyo pochiza GERD ndi eophaive esophagitis pofuna kupewa kuyambiranso, ndikofunikira kutenga Nexium 20 mg kamodzi patsiku kwa miyezi ingapo.

Ndi GERD popanda esophagitis, Nexium iyenera kumwa 20 mg kamodzi patsiku kwa masabata anayi. Ngati mankhwalawa atatha kuthandizira, zizindikiro za GERD sizinathere, muyenera kupitiliza kumwa mankhwalawa kwa milungu ina inayi popanda kusokonezedwa.

Pambuyo pochiritsidwa kwa GERD popanda esophagitis, Nexium imatha kumwa "pakufunika", ndiye kuti, ngati zizindikiro zowawa zikuwoneka, muyenera kumwa piritsi limodzi la 20 mg kuti muimitse. Nthawi yomweyo, kuyendetsa mosalekeza kwa Nexium sikofunikira.

Zochizira ndi kupewa kuyambiranso kwam'mimba kapena zilonda zam'mimba zophatikizana ndi Helicobacter pylori, Nexium iyenera kumwedwa 20 mg kawiri patsiku kwa sabata limodzi. Mankhwalawa zilonda zam'mimba Nexium imagwiritsidwa ntchito ngati gawo la mankhwala osakanikirana, komanso kugwiritsa ntchito prophylactic - kudzipatula.

Popewa kuyambiranso kwa anthu omwe amataya magazi chifukwa cha zilonda, Nexium yothandizira kukhazikitsa mankhwala ochepetsa mphamvu ya asidi imayamba kutumikiridwa mu 40 mg kamodzi patsiku kwa masabata awiri mpaka atatu, kenako imamwa pakamwa ngati mapiritsi a 40 mg kamodzi patsiku kwa masabata anayi.

Pochiritsa zilonda zam'mimba zomwe zimayambitsidwa chifukwa chogwiritsidwa ntchito kwa nthawi yayitali kuchokera ku gulu la NSAID, Nexium iyenera kumwedwa 20 mg kapena 40 mg kamodzi patsiku kwa masabata 4 mpaka 8. Popewa zilonda zam'mimba kapena zilonda zam'mimba pamene mukumwa ma NSAIDs, Nexium iyenera kumwedwa 20 mg kapena 40 mg kamodzi tsiku lililonse panthawi yonse yogwiritsira ntchito NSAIDs.

Zochizira matenda osiyanasiyana ogwirizana ndi pathological owonjezera kupanga hydrochloric acid (Zollinger-Ellison syndrome, etc.), Nexium amayamba kutenga 40 mg kawiri patsiku.Ngati mulingo wotere sunayambitse kuchotsedwa kwa zizindikiro, ndiye kuti ziyenera kuwonjezeka mpaka mtengo womwe umunthuwo umakhalapo. Mlingo wovomerezeka wa Nexium ndi 120 mg kawiri pa tsiku.

Kuchepetsa mulingo wa Nexium mwa okalamba ndi odwala sikofunikira. Kulephera kwambiri kwa chiwindi, mlingo waukulu wa tsiku ndi tsiku wa Nexium ndi 20 mg, ndipo modekha komanso modekha, ndi wofanana ndi kwa anthu ena onse. Kwa ana ochepera zaka 12, mapiritsi a Nexium amatsutsana, ndipo achinyamata azaka 13 amatenga mankhwalawa.

Zomwe zili bwino: kukwera kapena omez?

Ubwino wa Pariet ndi zotsatira zake zazitali komanso kukhudzana kwambiri. Chifukwa chake, limagwiritsidwa ntchito pazinthu zazikulu monga kukonzanso zilonda m'mimba zomwe zimachitidwa pachifukwa ichi. Sichimayambitsa zotsatira zoyipa, zimalekeredwa bwino ndipo sizimagwira ntchito zamankhwala, zomwe ndizofunikira kwambiri kwa odwala omwe ali ndi matenda amtima, kupuma ndi machitidwe ena.

Omez sagwiritsidwa ntchito osati zilonda zam'mimba komanso GERD, komanso wofatsa m'mankhwala: gastritis, zizindikiro za kudzimbidwa. Mwayi wawukulu wa Omez ndi kuthekera kwa kusankhidwa kwake kwa amayi apakati ndi ana omwe ali ndi zaka ziwiri (Pariet amaloledwa kokha kuchokera 12, ndipo amatsutsana panthawi yokhala ndi pakati).

Pariet amapangidwira mapiritsi okha, ndipo Omez amakhalanso ndi mafayilo olimbitsa thupi, mitundu yosiyanasiyana yophatikizidwa ndi domperidone, yomwe ndiyofunikira kuphwanya ntchito yamoto yogaya chakudya. Kwa odwala omwe amavutika kumeza mapiritsi kapena makapisozi, pali Omez Insta, pomwe kuyimitsidwa kumakhala kosavuta kwa kumeza.

Kuuluka ndi okwera mtengo kwambiri kuposa Omez, motero ndizofunikira kwambiri, ndipo m'mizinda yaying'ono sikungapezeke komwe kumagulitsidwa.

Omez kapena Pariet - chomwe chiri bwino: lingaliro la akatswiri

Akatswiri-gastroenterologists nthawi zambiri amakonda Pariet, chifukwa amawona kugwira bwino kwake komanso kulolera bwino. Izi zimatsimikiziridwa ndi maphunziro azachipatala. Ndemanga zambiri zakuchipatala zimawonetsa chitetezo cha Parieta mwa okalamba, omwe amakakamizidwa nthawi zonse kumwa mankhwala ambiri. Omez, atapatsidwa mgwirizano wokhudzana ndi mankhwala, sizoyenera pankhaniyi.

Cholepheretsa chokha pakusankhidwa kwa Pariet ndi mtengo wake wokwera: sikuti aliyense angakwanitse. Chifukwa chake, tikulimbikitsidwa milandu yambiri. Ndipo pochiza matenda am'mimba, GERD popanda kukokoloka komanso chifukwa cha prophylactic ndi mankhwala a Omez.

Kuyimitsidwa (ma pellets kapena granules yankho) Nexium - malangizo ogwiritsira ntchito

Mbale kapena mphete zimagwiritsidwa ntchito kukonza kuyimitsidwa kwamlomo. Kukonzekera kuyimitsidwa, zomwe zili mu chikwama chimodzi cha Nexium ziyenera kusungunuka mu 15 ml ya madzi osakanikirana, sakanizani bwino ndikudikirira masekondi 30 mpaka kuyimitsidwa kophatikizana kumapangidwa. Ngati mukufunika kutenga mapiritsi oposa amodzi a mankhwalawa, ndiye kuti kuchuluka kwa madzi kumawerengeredwa potengera kuchuluka kwa 15 ml pachikwama chimodzi. Ndiko kuti, kusungunula matumba awiri a granules (pellets) Nexium adzafunika 30 ml ya madzi, ndi zina. Kuyimitsidwa kumaliza kumayenera kuledzera nthawi yomweyo kapena kwa theka la ola. Mutatha kumwa kuyimitsidwa, onjezerani madzi ena 15 ml ku chikho chimodzi, sakani mankhwala otsalawo ndikumwa njira yotsatirayo. Pokonzekera mwachangu yankho la Nexium, ma granules sayenera kuphwanyidwa kapena pansi.

Mlingo ndi nthawi yayitali yamankhwala zimatsimikiziridwa ndi zaka za munthu komanso mtundu wa matenda.

Kwa ana azaka zapakati pa 1 mpaka 11 ndi thupi lolemera kuposa makilogalamu 10, ma pellets a Nexium ayenera kuperekedwa kokha pochizira GERD. Chithandizo cha GERD ndi esophagitis mwa ana omwe ali ndi kulemera kwa 10 - 20 makilogalamu amachitika ndi Nexium 10 mg (1 sachet) 1 nthawi patsiku kwa masabata a 8. Ngati kulemera kwa thupi kwa mwana kupitirira 20 kg, ndiye kuti mankhwalawa amvedwa ndi GERD ndi esophagitis, amatha kutenga Nexium 20 mg (2 sachets) kamodzi patsiku kwa milungu 8. Kuchepetsa GERD popanda esophagitis, ana ayenera kumwa Nexium 10 mg (1 sachet) 1 nthawi patsiku kwa milungu 8.

Akuluakulu ndi ana opitilira zaka 12 amatenga mapiritsi a Nexium (granules) mumagawo omwewo ndipo malinga ndi zomwe amafanana ndi malamulo monga mapiritsi (onani gawo la "Nexium 20 mg ndi mapiritsi a 40 mg - malangizo ogwiritsira ntchito").

Kuchepetsa mulingo sikufunika mwa okalamba, mwa iwo omwe ali ndi vuto la impso komanso ofatsa kapena olimba pakutha kwa chiwindi. Kulephera kwambiri kwa chiwindi, mlingo wa Nexium umakhala wochepa mpaka 20 mg (2 sachets) patsiku.

Lyophilisate Nexium - malangizo ogwiritsira ntchito

Mothandizidwa kulowetsedwa kwa mankhwalawa amagwiritsidwa ntchito ngati njira ina piritsi kapena pellets ngati munthu sangathe kumeza mankhwalawo pazifukwa zilizonse. Amatha kumeza mankhwalawa, munthu amamugwirira kuti alandire Nexium mwanjira ya mapiritsi kapena pellets. Mlingo wa kukonzekera kwamitsempha ya Nexium umatsimikiziridwa ndi mtundu wa matenda.

Pochizira GERD ndi esophagitis, Nexium imayendetsedwa pa 40 mg (1 botolo) kamodzi patsiku. Kuti athetse zisonyezo za GERD, kupitilira popanda esophagitis, 20 mg (theka la botolo) la lyophilisate amaperekedwa.

Pochiritsa ndi kupewa zilonda zam'mimbazi zomwe zimagwiritsidwa ntchito ndi NSAIDs, Nexium imaperekedwanso 20 mg (theka la botolo) kamodzi patsiku.

Popewa kutuluka kwa magazi kuchokera ku zilonda zam'mimba pambuyo pa endoscopy, 80 mg (mabotolo awiri) a Nexium amayenera kuperekedwa ngati kulowetsedwa kosatha theka la ola. Kenako, Nexium imayendetsedwa mu mawonekedwe a dontho (kulowetsedwa) pamlingo wa 8 mg pa ola limodzi kwa masiku atatu. Mukamaliza kupanga mtsempha wa magazi a Nexium, muyenera kusintha mankhwalawo ngati mapiritsi kapena mapiritsi 40 a 40 mg kamodzi patsiku kwa masabata anayi.

Malangizo pokonza njira zothetsera jekeseni wamkati ndi kulowetsedwa (otsikira):

Lyophilisate iyenera kusungunuka kokha ndi mchere wosabala,
Njira yokhazikitsidwa ndi Nexium singaphatikizidwe ndi mankhwala ena,
Njira yothetsera vutoli iyenera kukhala yowonekera popanda zosakhudza kapena zoipitsa,
Njira yothetsera vutoli iyenera kuperekedwa nthawi yomweyo kukonzekera kapena kwa maola 12,
Mutha kusungabe yankho pa kutentha osaposa 30 o C,
Kuti mupeze jakisoni, ma lyophilisate ochokera botolo limodzi ayenera kusungunuka ndikuwonjezera 5 ml ya saline yanyama,
Kwa dontho (kulowetsedwa), ma lyophilisate ochokera botolo limodzi ayenera kusungunuka mu 100 saline.

Malamulo opaka mtsempha wa njira ya lyophilisate:

40 mg kapena 20 mg ya Nexium (1 kapena 0,5 botolo la lyophilisate yosungunuka) imayendetsedwa kwa mphindi zosachepera zitatu,
40 mg kapena 20 mg ya Nexium (1 kapena 0,5 vial ya kusungunuka kwa lyophilisate) imayendetsedwa ngati kulowetsedwa kwakanthawi kwa mphindi 10 mpaka 30,
80 mg ya Nexium (mbale 2) amathandizidwa ngati kulowetsedwa kwa mphindi zosachepera 30,
Zosagwiritsidwa ntchito zotsalira za njira ya lyophilisate ziyenera kutayidwa, osasungidwa.

Ngati mukukumana ndi kusanza, kumeza movutikira, kapena kuchepa kwa thupi mutatenga Nexium, muyenera kufunsa dokotala ndikuyesedwa kwa matenda ena a pathologies. Mukamatenga Nexium kwa nthawi yoposa chaka, ziyenera kuonedwa ndi dokotala. Ngati mukugwiritsa ntchito Nexium "pakufunikira" pakhala pali kusintha kulikonse pazizindikiro, ndiye muyenera kufunsa dokotala posachedwa.

Kuchita ndi mankhwala ena

Nexium imalumikizana ndi mankhwala a HIV / AIDS (atazanavir, ritonavir, nelfinavir, saquinavir), zomwe zimapangitsa kusintha kwa mayamwidwe awo komanso kuyika magazi m'magazi. Kuphatikiza apo, kuchuluka kwa mankhwalawa kwa antiviral sikukutitsa mphamvu ya Nexium, chifukwa chake, mankhwalawa sangathe kugwiritsidwa ntchito palimodzi.

Nexium imabweretsa kuwonjezeka kwa ndende yamagazi a mankhwala otsatirawa:

Diazepam
Citalopram,
Imipramine
Clomipramine,
Phenytoin
Cilostazol

Pogwiritsa ntchito nthawi yomweyo ya Nexium ndimankhwala omwe ali pamwambapa, mulingo wotsiriza uyenera kuchepetsedwa ndi 30 - 40%.

Rifampicin ndi kukonzekera komwe kumakhala ndi wort ya St. John kumapangitsa kutsika kwa Nexium m'magazi a magazi.

Nexium ya ana - momwe angatenge

Ana omwe ali ndi thupi lolemera zosakwana 10 makilogalamu komanso osakwana 1 chaka sayenera kutenga Nexium. Ana a zaka zapakati pa 1 mpaka 11 ndi thupi lolemera 10 mpaka 20 makilogalamu amatenga 10 mg (1 sachet) yokha ya Nexium kamodzi patsiku. Ana olemera 20 kg amatha kutenga 20 mg (2 sachets) a Nexium patsiku.

Nexium mwa ana imagwiritsidwa ntchito kokha pochizira GERD, yomwe imakhala tsiku lililonse 10 mg kapena 20 mg ya pellets kwa masabata a 8.

Nexium - analogues

Ma Synonyms a Nexium ndi awa:

Neo-Sext
Mapiritsi a Esomeprazole
Makapisozi a Emanera.

Mankhwala otsatirawa ndi fanizo la Nexium:
1. Mapiritsi a Beret,
2. Makapisozi a Gastrozole,
3. Makapisozi a Helikon,
4. Makapisozi a Dexylant,
5. Zhelkizol lyophilisate,
6. Zerocide makapisozi,
7. Mapiritsi a Zipantola
8. Mapiritsi a Zolispan
9. Mapiritsi a Zulbek
10. Mapiritsi owongolera ndi ufa pakukonzekera njira yothandizira makonzedwe amkati,
11. Mapiritsi a Krosacid
12. Lanzabel makapisozi,
13. Lanzap makapisozi,
14. Lansoptol makapisozi,
15. Lansoprazole Stada Makapisozi,
16. Makapu apamwamba,
17. Makapisozi apamwamba,
18. Mapiritsi a Losek ndi lyophilisate,
19. Zojambula za Lozenzar-Sanovel,
20. Mapiritsi a Nolpase,
21. Mapiritsi a Noflux
22. Makapisozi a Omez ndi lyophilisate,
23. Omez Insta ufa woyimitsa pakamwa,
24. Makapisozi a Omecaps,
25. Makapisozi a Omeprazole,
26. Makapisozi a Omeprus,
27. Makapisozi Omefes,
28. Makapisozi a Omizak,
29. Makapisozi a Omipix,
30. Makapisozi a Omitox,
31. Mapiritsi a Ontime
32. Makapisozi a Orthanol,
33. Kapisozi wa Ocid,
34. Mapiritsi a Pantaz
35. Mapiritsi a Panum,
36. Kukula mapiritsi
37. Mapaketi
38. Mapiritsi a Peptazole
39. Pizhenum - mapiritsi a Sanovel,
40. Makapisozi a Pleoma-20,
41. Prosthesis makapisozi
42. Mapiritsi a Puloref,
43. Ma kapu a Rabeprazole-OBL
44. Rabelok lyophilisate,
45. Makapisozi a Romesek,
46. Mapiritsi a Sanpraz ndi lyophilisate,
47. Makapisozi a Sopral
48. Ulcosol makapisozi ndi lyophilisate,
49. Ultra piritsi,
50. Makapisozi a Ultop ndi lyophilisate,
51. Mapiritsi a Hayrabesol,
52. Makapisozi othandizira ndi ma lyophilisate,
53. Makapu osagwirizana,
54. Epicurus makapisozi.

Ndemanga za Nexium

Chiwerengero chochepa cha ndemanga zoyipa za mankhwalawa Nexium sichiri kawirikawiri chifukwa cha kusakwanira kwake. Nthawi zambiri, chifukwa chomwe amawunikira molakwika ndi chiyembekezo chokhudza mankhwalawa, pomwe anthu aganiza kuti "mapiritsi amatsenga" sangangochotsa zisonyezo kapena kuchiritsa matendawa, koma adzawapangitsa kukhala athanzi kwathunthu.

Omez kapena Nexium?

Maziko ogwira ntchito kwambiri a Nexium ndi kukhudzika kwake kwakukulu, komwe kumakhala kwakukulu kwambiri kuposa mankhwala onse ochokera ku gulu la proton pump zoletsa za m'badwo woyamba, omwe akuphatikizapo Omez. The bioavailability wa Nexium imatsimikizika ndi kapangidwe kake kapadera kama kemikali, chifukwa chofikira maselo am'mimba mokulira kwambiri poyerekeza ndi Omez. Kuphatikiza apo, Nexium amatha kukhala ndi khola komanso kukhazikika m'magazi pambuyo pakulowetsa, pomwe Omez alibe. Mukamamwa Omez, kuchuluka kwa mankhwala omwe amagwira ntchito m'magazi kumasiyana kwambiri, komwe kumayambitsa kuchiritsika kwa mankhwala kwa nthawi.

Pankhani yokhudza zochizira, zabwino za Nexium kuposa Omez ndi izi:
1. Bwino komanso moyenera kuneneratu kusintha kwa gastric acidity.
2. Ambiri amachiritsa panthawi yochepa ya zamankhwala.
3. Kuthetsa zizindikiro zopweteka komanso kuchiritsa kwa zotupa m'matumbo am'mimba, duodenum ndi esophagus.
4. Kutumiza kutentha kwa mtima ndi zizindikiro zina za GERD pagulu lalikulu la odwala.

Mwakuchita kwake kachipatala, Nexium ndiwopambana kuposa mankhwala ena onse a gulu la proton pump inhibitor. Chifukwa chake, pamayesero azachipatala adapezeka kuti Nexium amachiritsa GERD mkati mwa mwezi umodzi, ndipo Omezu adzafunika pafupifupi miyezi iwiri kuti akwaniritse zotsatira zomwezo.

Pochiza zilonda zam'mimba kapena zam'mimba zophatikizana ndi Helicobacter pylori, kugwiritsidwa ntchito kwa Nexium kuphatikiza maantibayotiki kuti athetse michere kumapangitsa kuchira kwathunthu ndikuwonetsa zilonda m'masiku asanu ndi awiri okha. Poyerekeza, muyenera kudziwa kuti chithandizo chokhazikika ndi omez kapena proton pump inhibitor imachitika mkati mwa masabata atatu. Ndiye kuti, kugwiritsidwa ntchito kwa Nexium pakuphatikiza zilonda zam'mimba kumachepetsa nthawi yayitali ya mankhwala katatu.

Chifukwa chake, zitha kunenedweratu mosadukiza kuti Nexium ili ndi katundu wabwino komanso luso lapamwamba lachipatala poyerekeza ndi Omez.

Nexium kapena Emanera?

Mukukonza mankhwala oyamba, kaphatikizidwe ndi kudzipatula kwa chinthu chomwe chimagwira, kuyeretsa kwake kwa mankhwala ndi kufufuza mokwanira kwa nyumbazo kumachitika. Pambuyo pokhazikitsa tekinoloje yakukonzekera ndi kuyeretsa chinthu kuchoka pazinthu zosayera ndikomwe imaphatikizidwa pakupanga mankhwala ndikutetezedwa ndi patent. Mwachilengedwe, zovuta zonse zaukadaulo zopangira zinthu zogwiritsidwa ntchito ndizobisika komanso zamalonda. Koma makampani ena amathanso kupanga kaphatikizidwe kameneka ndi kumasula mankhwala omwe ali ndi dzina lina, lomwe liziwoneka kuti ndi generic, chifukwa kukwezeka pakupezeka kwa mankhwala ophatikizana ndi vuto lina.

Makampani a generic satsuka mankhwala ogwiritsira ntchito mokwanira, gwiritsani ntchito zinthu zina zothandizira, chifukwa mankhwalawo amatha kukhala ndi zovuta zambiri komanso kuwononga kwambiri zotsatira zoyipa, ndipo mphamvu yachipatala imakhala yotsika kwambiri poyerekeza ndi yoyambayo. Chifukwa chake, kusiyana pakati pa zoyambayo ndi generic ndizodziwikiratu.

Komabe, Emanera si generic wamba wopangidwa ndi makampani ambiri azamankhwala aku India. Chowonadi ndi chakuti Emanera amapangidwa ndi nkhawa wodziwika bwino wamankhwala Krka, yemwe adapatsidwa zolembedwa zofunikira kuti apange mankhwala opangidwa ndi generic makamaka kuti apange mankhwala okwera mtengo. Chifukwa chake, kusiyana pakati pa Emanera ndi Nexium ndikochepa, ndipo mutha kusankha mankhwala aliwonse. Ngati pakufunika kuchepetsa mtengo wa chithandizo, ndiye kuti Emanera wotsika mtengo ayenera kukondedwa. Ndipo posakhala zoletsa zilizonse, mutha kusankha Nexium. Ngati palibe chidziwitso chomwe chimatikakamiza kusankha Nexium kapena Emanera, ndiye kuti mutha kugula mankhwala aliwonse omwe mumafuna pazifukwa zina, mwachitsanzo, kuyikiratu kumakhala kokongola, ndi zina zambiri.

Nexium - kugula?

Zidziwitso zolakwika nthawi zina zimapezeka pa intaneti pankhaniyi, chifukwa chake timvetsetsa zambiri.

Omeprazole ndi rabeprazole gwirizana ndi proton pump zoletsa (IPP). Synonym - proton pump blockers . Awa ndimankhwala omwe amalepheretsa kubisika kwa hydrochloric acid (HCl) m'mimba, motero amakhudzana ndi mankhwala antisecretory ndipo amagwiritsidwa ntchito pofuna kuchiza acidity yam'mimba. Proton pump inhibitors (proton pump blockers) amachepetsa kubisalira hydrogen ayoni (H +, kapena proton) maselo a m'mimba. Makina obisalira ali mu extracellular potaziyamu potionum ion (K +) wolowa mu cell posinthanitsa ndi hydrogen ion (H +).

Gulu ndi Khalidwe

Pano zikugwiritsidwa ntchito Magulu atatu mankhwala omwe amachepetsa acidity m'mimba:

proton pump zoletsa - ndi mankhwala amphamvu kwambiri oteteza khungu lathu m'mimba. Zovomerezeka katatu patsiku,
H 2 blockers (werengani al-two) - ali ndi mphamvu zochepa zowononga chifukwa chake amatha kuikidwa pokhapokha pofatsa. Amatengedwa kawiri patsiku. Ma histamine (H 2 -) ma cell a parietal a mucosa am'mimba amatsekedwa. H 2 blockers akuphatikiza mathitidine ndi genotidine .

Zokhudza: H 1 -blockers amagwiritsidwa ntchito motsutsana chifuwa (loratadine, diphenhydramine, cetirizine ndi ena).

maantacid (potanthauzira "motsutsana acid ") - amatanthauza potengera maginito a magnesium kapena aluminium, omwe amalepheretsa (kumanga) hydrochloric acid m'mimba. Izi zikuphatikiza almagel, phosphalugel, maalox ndi ena: Amachitapo kanthu mwachangu, koma kwa nthawi yochepa (mkati mwa ola limodzi), kotero, amayenera kutengedwa nthawi zambiri - maola 1.5-2 atatha kudya komanso asanagone. Ngakhale ma antacid amachepetsa acidity m'mimba, nthawi yomweyo amawonjezera kubisika kwa hydrochloric acid ndi makina mayankho olakwika chifukwa thupi limayesa kubwezeretsa pH (acidity, imachokera ku 0 mpaka 14, pansipa 7 - acidic chilengedwe, pamwambapa 7 - zamchere, chimodzimodzi 7 - osalowerera) ku mfundo zam'mbuyomu (pH yachilendo m'mimba ndi 1.5-2).

Mpaka proton pump zoletsa phatikizani:

(mayina amalonda - omez, losek, ultop ),
(mayina amalonda - Nexium, Emanera ),
lansoprazole (mayina amalonda - lantsid, lansoptol ),
pantoprazole (mayina amalonda - nolpaza, zowongolera, chitetezo chaukhondo ),
rabeprazole (mayina amalonda - akuuluka, noflux, ontay, zulbeks, hairabesol ).

Kuyerekeza Mtengo

Omeprazole zimadula kangapo mtengo kuposa rabeprazole .

Mtengo wa ma generics (analogues) wa 20 mg wa 30 makapisozi ku Moscow pa february 14, 2015 ndi kuchokera ku ruble 30 mpaka 200. Kwa mwezi wamankhwala, mapaketi awiri amafunikira.

Mtengo wa mankhwala oyamba Zikukwera (rabeprazole ) 20 mg 28 tabu. - 3600 rub. Kwa mwezi wa chithandizo, phukusi limodzi likufunika.
(analogues) rabeprazole ndi wotsika mtengo kwambiri:

Nthawi 20 mg 20 tabu. - 1100 rub.
Zulbek 20 mg 28 tabu. - 1200 rub.
Tsitsi 20 mg 15 tabu. - 550 rub.

Mwanjira imeneyi mtengo wa chithandizopamwezi ndi ma ruble 200 (40 mg / tsiku), rabeprazole mukamagwiritsa ntchito makulidwe - pafupifupi ma ruble 1150. (20 mg / tsiku).

Kusiyana pakati pa omeprazole ndi esomeprazole

Ndi S-stereoisomer (mkono wamanzere wamanzere pakuyenda), wosiyana ndi isomer lamanja lamanzere momwemonso dzanja lamanzere ndi lamanzere kapena lamanzere ndi lamanja. Zinapezeka kuti mawonekedwe a R ndi olimba kwambiri (kuposa mawonekedwe a S-) amawonongeka akamadutsa m'chiwindi motero safika pamatumbo am'mimba. Omeprazole ndi chisakanizo cha ma stereoisomers awiriwa.

Malinga ndi mabuku, ili ndi zabwino zake zambiri poyerekeza, koma imawononga ndalama zambiri. kumwedwa yomweyo.

Mtengo mayina amalonda ndi:

Nexium 40 mg 28 tabu. - 3000 rub.
Emanera 20 mg 28 tabu. - 500 rub. (Mapaketi awiri pamwezi).

Ubwino wa rabeprazole kuposa ma PPI ena

Zotsatirarabeprazole Imayamba mkati mwa ola limodzi pambuyo pa kuwongolera ndipo imatenga maola 24. Mankhwalawa amagwiritsidwa ntchito mosiyanasiyana pH (0.8-4.9).
Mlingo rabeprazole ndi yotsika 2 poyerekeza ndi omeprazole, yomwe imapereka kulekerera bwino kwa mankhwalawa komanso zotsatira zoyipa zochepa. Mwachitsanzo, kafukufuku wina, zotsatira zoyipa (mutu, chizungulire, kutsegula m'mimba, nseru, zotupa pakhungu ) zidadziwika pa 2% mankhwalawa rabeprazole ndi inu 15% pa mankhwala.
Kuvomerezedwa rabeprazole m'magazi ochokera m'matumbo (bioavailability) sizitengera nthawi yakudya.
Rabeprazole wodalirika koposa amalepheretsa katulutsidwe wa hydrochloric acid, chifukwa kuwonongeka kwake m'chiwindi sikudalira kutengera kwa mitundu ya cytochrome P450 enzyme. Chifukwa chake, ndizotheka kuneneratu bwino momwe mankhwalawo amathandizira odwala osiyanasiyana. Rabeprazole ochepera monga mankhwala ena amakhudza kagayidwe (chiwonongeko) cha mankhwala ena.
Pambuyo discontinuation rabeprazolepalibe "rebound syndrome" (kuletsa), i.e. palibe kukakamira kowukitsa kuchuluka kwa acidity m'mimba. Hydrochloric acid secretion imabwezeretsedwa pang'onopang'ono (mkati mwa masiku 5-7).

Zisonyezo za kutenga proton pump zoletsa

gastroesophageal Reflux matenda (Reflux ya acidic yam'mimba m'mimba).
pathological hypersecretion ya hydrochloric acid (kuphatikizapo Zollinger-Ellison syndrome),
mankhwalawa amagwiritsidwa ntchito kuti athetse (kuthetsa) matenda a Helicobacter pylori (Helicobacter pylori), omwe amachititsa zilonda zam'mimba komanso matenda osachiritsika.

Zindikirani Onse ovomerezeka a proton pump amawonongeka m'malo acidic , motero, amapezeka mu mawonekedwe a makapisozi kapena mapiritsi obisika, omwe kumeza lonse (simungathe kutafuna).

Mwachidule: rabeprazole ≅ esomeprazole> omeprazole, lansoprazole, pantoprazole .

Zambiri: rabeprazole ali maubwino angapo Pamaso pa proton pump zoletsa zina ndi zina zokhudzana ndi mphamvu poyerekeza ndi chithandizo, komabe rabeprazole zimawononga ndalama zowirikiza kasanu poyerekeza ndi zokwera mtengo pang'ono poyerekeza.

Malinga ndi mabukuwa, kugwiritsa ntchito mphamvu ya Helicobacter pylori kuthetsa sikudalira kusankha kwa proton pump inhibitor (iliyonse yomwe ingatheke), mukadali chithandizo gastroesophageal Reflux matenda olemba ambiri amalimbikitsa rabeprazole .

Antihypertensive fanizo la mankhwala

Pakati proton pump zoletsa 3 mankhwala amaperekedwa:

(mankhwala osokoneza bongo oyipa)
(Kukonzekera bwino kutengera S-stereoisomer of omeprazole),
rabeprazole (otetezeka).

Ziwerengero zofananira izi zimapezeka pakati pa omwe amagwiritsidwa ntchito pochiza matenda oopsa:

amlodipine (ndi zovuta)
levamlodipine (Kukonzekera bwino kutengera S-stereoisomer yokhala ndi zovuta zochepa),
lercanidipine (otetezeka kwambiri).

Ndemanga 7 ku cholembapo kuti: "Ubwino ndi uti - omeprazole kapena rabeprazole? Phindu la rabeprazole "

Ubwino wa Hyrabesol:
Hyrabezol akulimbikitsidwa KWA ANA kuyambira zaka 12.
Moyo wa alumali wa Hairabesol ndi zaka 3.
Ma CD amtundu wapadera.
Hyrabezol alibe ufulu wakudya

Nkhani yanga ndi iyi: adotolo andipatsa Ultop. Pambuyo pa kugwiritsidwa ntchito kamodzi, panali zovuta zoyipa: mutu wakuthwa, wofiyidwa ndikuyamba kuwona diso limodzi moyipa, palpitations ndi fever. Dokhtura adanenapo izi, koma sakhulupirira ine - akuti palibe zomwe zingachitike kuchokera ku ultop ndikusankha Omez-Insta. Ndabwera kunyumba, ndidaganiza zowerenga, koma zimadzakhala zofananazo, zimangokhala dzina lokhalo!

Mwambiri, zikomo kwa inu, ndazindikira zambiri ndipo ndidziyang'ana ndekha zomwe sizingachitike popanda zovuta zoyipa. Ndikulakalaka ndikadapeza katswiri wazachipatala pano ... (((

Zaka 4 zapitazo, adathandizira gastritis ndi ultrasound, mwachiwonekere, sizinathandize, chifukwa kukokoloka kwa m'mimba kunapezeka chaka chino. zulbek zotchulidwa. Sindinapite kudziko lotsatira ndi mapiritsi awiri: ola limodzi nditatha kumwa mankhwalawa, khosi langa lidadwala tsiku loyamba ndipo kutsokomola kwanga kunayamba, chilakolako changa cha chakudya chinatha, ndipo m'mawa tsiku lachiwiri kunali kumva ululu m'mimba ngati cystitis. komabe adaganiza z kumwa piritsi lina. kachiwiri, kutatha ola limodzi, kulowa kutentha, kutentha 38,5, msana udadwala, mutu sukuganiza konse, kupweteka mthupi lonse, zonse zili mkati mwake mkati. Ndidawerengera zotsatira zoyipa pambuyo pake kuti zulbek nthawi zambiri zimayambitsa matenda ngati chimfine ndi matenda a genitourinary system. ndipo uwu ndi mankhwala otetezeka kwambiri omwe mukufuna kunena. ndi ultrasope izi sizinali, pakamwa pouma kwambiri komanso kuchepa kwa chilakolako cha kudya. mwa njira, mwina mlingo wa 20 mg ndi wamkulu kwambiri kwa ine, chifukwa kulemera kwanga ndi 39 kg

Tsoka ilo, a Zulbeks (rabeprazole), ngakhale anali ndi mapindu, siotetezeka monga momwe zimawonekera poyamba. Komabe, Ultop (omeprazole) imathandizanso kutopa, kufooka, kuchuluka kwa thupi, komanso kutentha thupi. Izi zimafotokozedwa mogwirizana ndi malangizo a mankhwalawa. Ponena za mlingo, 10 kapena 20 mg ya rabeprazole patsiku (osapitirira 20 mg) amagwiritsidwa ntchito nthawi zambiri. Chifukwa chake, rabeprazole sakukwanira, muyenera kubwerera ku omeprazole kapena kuyesa esomeprazole.

Zikomo chifukwa cha ndemanga. Ndidawerengapo, koma adotolo adandiwuza, ndikunena kuti mankhwalawa amalekeredwa bwino ndipo amathandiza kwambiri. Koma osandiuza kutalika komwe kumachotsedwa m'thupi? lero sindinamwe mapiritsi aliwonse, koma kutentha kwanga kudakali pafupifupi 37.3, ululu wanga wammbuyo wapita, mmero mwanga ulibe kuchepa, kufooka kwanga kwatha kale, kulakalaka kwanga kwabwerera. nthawi yotsiriza ndidamwa mankhwalawa tsiku lapitalo. za ultop Ndinakumbukira kuti kuchokera kwa ine tsitsi langa lidayamba kugwa mwamphamvu (izi zimanenedwanso m'malamulo).

Rabeprazole imachotsedwa m'thupi mwachangu, zimangotsala ndi tsiku limodzi, komabe, mphamvu ya mankhwalawa imatha pafupifupi tsiku limodzi. Mwambiri, m'masiku 4-5, zoyipa zimatha. Monga cholowa mmalo, mutha kuyesa esomeprazole, kapena kusinthana ndi ma H 2 blockers, koma amalepheretsa kubisalira kwa hydrochloric acid.

Moni Ndinawerenga ndemanga ya Jeanne ndipo anali wokondwa pang'ono; Amasinthidwa ndi dontho la nexium. Poyamba panali kumva kuzizira komanso kunjenjemera, kenako ndinamverera kuti mchenga umabwera kuchokera ku impso, patsiku lachiwiri khosi langa limatentha komanso kutentha kunali 37, ndiye masiku angapo pambuyo pake adatulukira, zilonda pakamwa panga. Ndapeza izi m'malemba anga - adandifunsa kuti ndiziwerenga bukuli.

Pang'onopang'ono, zotsatira zoyipa zimasowa, mankhwalawo adathetsedwa, koma chakudya chake chidawonedwa chilimwe chonse, chifukwa cholakwika chochepa chidayambitsa moto m'boma lakumanzere. Sabata yapitayo, idayambanso kuwotchera nthawi zambiri m'masamba, motsutsana ndi kumbuyo kwa usiku wa 1 ndikuponyera (zikuwoneka kuti zidawonetsa masewera pamimba yopanda kanthu). Kenako mbali yakumanja idadwala kwambiri ndipo kufooka kunayamba. Ndinayesa kuthandiza Seth ndi Iberogast, tini achi China, koma ndinayenera kugwiritsa ntchito mankhwala. Ndinayamba kumwa Nexium dzulo - madzulo, thupi limapweteka komanso kufooka. Lero kulibe mphamvu tsiku lonse, kufooka kowopsa, sindingathe kuyenda. Khosi limadwalanso ndipo kutentha kudakwera 37-37.5. Poyamba ndimaganiza kuti ndikudwala, koma palibe zizindikilo zina zamatendawa ndipo kupindika sikungathandize. Chapakatikati ndidawoneka kuti palibe zovuta zambiri zoyipa, komabe kunalibe kufooka kwamphamvu chotere. Ndi mankhwala ati omwe angalowe m'malo? Kodi munganene chiyani za famotidine? Zokhudza zotsatira zake?

Pariet (rabeprazole), nolpase (pantoprazole), nexium (esomeprazole) ndi amodzi a gulu la proton pump blockers ndipo amatha kuyambitsa mavuto ofanana: malungo ndi chimfine. Ma H2-blockers (famotidine, ranitidine, roxatidine, nizatidine) amachititsa kutentha pang'ono, ndiye muyenera kuwayesa. Ali ndi zovuta zina, koma pali mwayi woti simudzakhala nawo kapena pang'ono pokha. Onani zovuta zomwe zimapezeka chifukwa cha mankhwalawo patsamba. mwaula.ru Yesani kaye zilembo za H2 zomwe zikukuyenererani pamtengo. Pazonse, blockers H2 ndi ofooka kuposa proton pump blockers. Osangogwiritsa ntchito cimetidine, ndi mankhwala osatha omwe ali ndi mavuto ambiri.

Kodi machesi otetezeka kwambiri a rabeprozole (akuuluka, noflux, ontime, zulbeks, hairabesol) ndi ati?

M'malingaliro, ma analogu onse ayenera kukhala ofanana. Mtundu wa dzina lodziwika (zonena, woyamba kulowa mumsika) ndi Pariet. Amakhulupirira kuti mankhwala abwino kwambiri ndiopanga ku Europe, America ndi Israeli. Koma kumbukirani kuti nthawi zina maodza amagulitsidwa ku Russia. Chifukwa chake, mutha kugwiritsa ntchito analogue (generic) ngati ikuthandizani ndipo sayambitsa mavuto.

Ndadwala kuyambira 1994. Ndili ndi matenda a catarrhal hernia a esophageal otseguka a diaphragm, catarrhal Reflux esophagitis, kukokoloka kwa antrum, gastroduodenitis wapamwamba. M'mbuyomu, panali zilonda zam'mimba ndipo chilonda chidapezeka mu duodenum. Amalandira chithandizo nthawi zonse kumalo komwe amakhala. Kuphatikiza pafupipafupi (pafupifupi tsiku lililonse) ndinatenga Omeprazole, yemwe anathandizira pang'ono komanso kwakanthawi (nthawi zina ndimatenga mapiritsi angapo nthawi kuti ndichotsere kutentha kwamkati). Kutentha kwa mtima sikugwira. Pafupifupi nthawi yomweyo, ndinali ndi vasomotor rhinitis. Panalibe chilichonse chopumira. Chifukwa chaichi ndimapopera utoto wa mahomoni. Pafupifupi osathandiza. Pazaka 4-5 zapitazi, wayambiranso kwambiri (kuyambira pa 46 mpaka 56-58). Kuyambira tsitsi posachedwa palibe chomwe chidzatsala. Kwa zaka ziwiri zapitazi, adayamba kutsamwa. Panali vuto lodzikhutira kotero kuti ndinali wabuluu-wachi. Pazifukwa zina, wothandizirayo adalemba mankhwala okhala ndi penicillin, omwe nthawi zonse ndimachita zoyipa ngati a Quincke's edema (ndidachenjeza). Kwa nthawi yayitali ndimalandira mankhwala opha ziwengo ndi mapiritsi okhala ndi mankhwala a mahomoni (kuchipatala). Chaka chatha adayamba kutsutsidwa mowonjezereka. Hemoglobin inatsika mpaka 88, mapuloteni mpaka 72-73. Ndikuthandizidwa ndi hematologist: kuchepa magazi m'thupi, mtima wadzuwa. (Kukakamizidwa kutenga sorbiferi. Maltofer wa hematologist woletsedwa mwachikhalidwe, samachiza). Gastroenterologist tsopano wasankha Pariet. Ndinkakayikira kwenikweni kufunika kotenga mankhwala okwera mtengo ngati amenewa. Koma ndinawerenga zidziwitso patsamba lanu zokhudzana ndi kugwiritsa ntchito mankhwalawa komanso zovuta zake, ndipo ndinazindikira kuti ndi iye yekha omwe angandithandizire. Ndi zovuta zonse mu mawonekedwe a kupuma movutikira, kupuma kwa bronchospasm, kuchuluka kwa thupi, kuchepa kwa tsitsi, kusawona bwino (ndinayamba kuwona bwino m'magalasi komanso opanda magalasi), kufooka kwambiri komanso zambiri, simungafotokoze chilichonse kuchokera ku Omeprazole. Sindinaganizirepo kuti Omeprazole akhoza kuchita zovulaza kuposa zabwino, komanso kukhala oopsa pa thanzi langa, zimawoneka zodalirika komanso zotsika mtengo.

Kodi ndidzapumulanso tsopano, malingaliro anga adzabwezeretsedwa, kodi kulemera kwanga kubwerera ku zachilendo, ...? (Mayeso a ziwengo ndi osavomerezeka, sindingathe kuwongolera kupita kwa a pulmonologist). Kodi wina wondiyankha mwaukadaulo, angalangize chilichonse chothana ndi izi?

Rabeprazole ndi omeprazole achokera pagulu lomwelo, motero mavuto awo amafanana. Musayembekezere kusintha kwakukulu.

Mphumu ndi vasomotor rhinitis nthawi zambiri zimagwirizana ndi asidi Reflux kuchokera kummero mpaka bronchi. Izi ndizovuta.

Zomwe omeprazole sizithandiza bwino sizodziwika bwinobwino. Pakutsimikizira, muyeso wa pH watsiku ndi tsiku uyenera kuchitika.

Komabe, ndikutsimikiza kuti omeprazole amachita, ndipo chifukwa chenicheni cha mavuto anu ndi heratal hernia. Njira yokhayo yothetsera izi (ndiye kuti moyo uyamba kusintha) ndi opareshoni. Mkhalidwe wanu sunyalanyazidwa, kotero kukonzekera musanachite opareshoni kudzafunika (onjezerani hemoglobin, ndi zina). Komabe, muyenera kuti mugwiridwe opareshoni, chifukwa mopitilira muyipire.

O.N. Minushkin, L.V. Maslovsky, Yu.N. Loshchinina, N.Yu. Anikina,
Educational and Science Science Center of the Purezidenti Administration wa Russian Federation

M'mayiko otukuka, m'zaka zaposachedwa, kuchuluka kwa matenda a gastroesophageal Reflux (GERD) kwachulukirachulukira. Zizindikiro za GERD zimakumana tsiku ndi tsiku mpaka 10% ya anthu, sabata lililonse ndi 30%, ndipo pamwezi ndi 50%. Njira yakuchulukirachulukira kwa GERD inali maziko olengeza pa 6th European Gastroenterological Week mawu akuti "XX century - m'badwo wa zilonda zam'mimba, XXI - m'badwo wa GERD".

Kafukufuku waku Russia omwe adachitidwa ngati gawo la pulogalamu ya WHO MONICA ku Novosibirsk adawonetsa pafupipafupi GERD poyerekeza ndi deta yomwe ili pamwambapa. Kutentha kwa mtima kumakumana ndi 61.7% ya amuna ndi akazi 63.6%, pomwe 10,3% ndi 15.1% nthawi zambiri kapena pafupipafupi (5). Zotsatira zamaphunziro athu, potengera kuwunika koyambira kwa zopezeka za endoscopy za 5107 gastroenterological odwala pazaka 5, zikuwonetsa kuti zizindikiro za endluthopos za Reflux esophagitis zapezeka mwa 1419 odwala (27.8%), omwe amuna 880 (28.8%) ndipo azimayi 539 (26.3%) (peresentiyo amapatsidwa chiwerengero chonse cha amuna kapena akazi). Catarrhal esophagitis adapezeka mwa odwala 890 (17.4%) - amuna 538 (17.8%) ndi azimayi 352 (17.2%). Erosive esophagitis - mu 529 adawunika (10,4%) - amuna 342 (11.2%) ndi akazi 187 (9.1%).

Chithandizo chokwanira cha GERD ndikofunikira, popeza matendawa amakhudza thanzi la odwala, komanso kupezeka kwa nthawi yayitali komanso kupendekeka kwa esophagitis kungayambitse kupindika, Barrett's esophagus ndi khansa yam'mero.

Chithandizo cha GERD chimaphatikizapo malingaliro osintha moyo wa wodwala komanso mankhwala othandizira (2). Odwala opanda esophagitis, cholinga chamankhwala ndicho kuthetseratu zizindikiro zomwe zimakhudzana ndi asidi Reflux (kutentha kwa kutentha kwa mtima, nthawi zina kupweteka kumbuyo kwa sternum) ndikukonza moyo wabwino. Pamaso pa esophagitis, chithandizo chimachitidwanso kuti muchepetse kukula kwa zovuta monga esophageal solidure kapena epithelial metaplasia (Barrett's esophagus).

M'mitundu yonse ya GERD, chithandizo choyambirira chimaphatikizapo njira zingapo zosagwiritsa ntchito mankhwalawa (kukweza mutu pabedi, kuchepa thupi, kuletsa zakudya, ndi zina) ndi kumwa maantacid. Ngati zizindikiro zikulimbana ndi izi, chithandizo cha mankhwala chikugwirizana kwa milungu iwiri. Njira zabwino kwambiri zoyambirira zamankhwala zosokoneza bongo ndi proton pump inhibitors. Zomwe zilipo pakadali pano zikuwonetsa mphamvu zofanana zamankhwala osiyanasiyana a gulu lino la mankhwala (omeprazole, lanzoprazole, pantoprazole, rabeprazole ndi esomeprazole) (9, 11). Kafukufuku wowerengeka akuwonetsa kukwera kwapadera kwa esomeprazole pa omeprazole pamlingo wopsinjika kwa katulutsidwe ka chapamimba komanso kuchuluka kwa zomwe zimachitika (10). Komabe, kusiyana komwe kumapezeka kumatha kukhala chifukwa cha mitundu yosiyanasiyana ya mankhwalawa (40 mg ndi 20 mg, motsatana).

Zomwe zinachitikira munthawi ya odwala a 115 (amuna a 77, azimayi 38, azaka zapakati pa 45.1 ± zaka 1,2) GERD 0-4 madigiri omeprazole, esomeprazole, rabeprazole mu Mlingo wokhazikika kwa masabata anayi adawonetsa kukhudzika kwambiri kwa matenda kukonzekera (6, 7, 8).

Mphamvu zamatenda azachipatala ndi endoscopic zimawonetsedwa mu tebulo 1 ndi 2.

Chiwerengero cha odwala omwe amachiritsidwa kwathunthu kukokoloka patatha milungu 4 mankhwala ndi ma PPIs osiyanasiyana, kutengera mtundu wa Reflux zsophagitis

Peresenti ya odwala omwe ali ndi mpumulo wathunthu pambuyo pamasabata 4 akuchira ndi ma PPI osiyanasiyana

Zomwe zidawonetsedwa zikuwonetsa kukhathamira kwa mankhwala onse omwe amagwiritsidwa ntchito pochiza kukokoloka, panalibe kusiyana kwakukulu mu kuchuluka kwa odwala omwe amachiritsidwa kwathunthu pambuyo pa milungu 4 ya chithandizo ndi Omez, Pariet kapena Nexium. Njira yofananayo idawonedwa pokhudzana ndi kupumula kwa zizindikiro, makamaka kutentha kwapakhosi. Gome 2 ikuwonetsa kuti Omez ali ndi mwayi.

Kuti muwone kuyesa kwa mitundu yosiyanasiyana ya mankhwala a kukonza, Omez adagwiritsidwa ntchito. Chimodzi mwazomwe zidasankha izi chinali chakuti Omez ndi imodzi mwazothekera kwambiri zotchinga pampweya wa proton ku Russia ndipo sizotsika pakugwira kwake ntchito zina kwa zoletsa zina za proton pamsika wama Russia.

Tidawerengera magwiridwe anayi a mitundu ya kukonza mankhwala ndi Omez (omeprazole) pa 20 mg kwa miyezi 12 mwa odwala omwe ali ndi GERD 0 ndi 1 tbsp. mukakwaniritsa matenda ndi endoscopic chikhululukiro ndi maphunziro:
1) kumwa Omez pa 20 mg / tsiku tsiku lililonse (gulu limodzi - odwala 20),
2) kumwa Omez pa 20 mg / tsiku lililonse tsiku lililonse (gulu 2 - anthu 20),
3) kumwa Omez mu 20 mg mu njira ya "kufunika": 20 mg / tsiku ndi kutentha kwamtima (gulu 3 - 20 odwala),
4) kumwa Omez pamwala wa 20 mg mwanjira ya "sabata": 20 mg / tsiku Lachisanu, Loweruka ndi Lamlungu (gulu la 4 - 15 odwala),
5) gulu lolamulira - odwala omwe sanalandire chithandizo chokonzanso (gulu la 5 - 30 odwala).

Odwala okwanira 105 adavomerezedwa pamaphunzirowa: Amuna 62 (amuna 59) ndi akazi 43 (41%). Odwala onse anali a fuko la ku Europe. Makhalidwe a gululi aperekedwa pagome 3.

Chikhalidwe cha odwala omwe adaphunzira

Asanaphatikizidwe mu phunziroli, odwala onse adadwala ma endoscopy (Gome 4), kuwunika kwa zizindikiro ndi moyo wabwino. Kuwunika kwamatenda am'mimba kumachitika miyezi itatu iliyonse. Kufufuza kuchuluka kwa GERD mu endoscopy kunachitika malinga ndi gulu la Savary-Miller pakusintha kwa Carisson et al. Odwala adasunga zolemba za tsiku ndi tsiku momwe adayesa kuchuluka kwa zizindikiritso pa sikelo ya Likert, ndipo chithunzi cha analogue wadogo (VAS) chinagwiritsidwa ntchito kuyesa moyo. Odwala adalandira chithandizo cha PPI muyezo wokwanira mpaka kukonzekera kwachipatala pambuyo pake, pambuyo pake adayikidwa kuti athe kukonza mankhwala ndi Omez mu umodzi mwa madongosolo.

Kugawidwa kwa odwala m'magulu kutengera kuchuluka kwa GERD

Gululi	Digiri ya GERD mu endoscopy
Gululi	GERD 0 madigiri	GERD 1 digiri
Gulu 1 (n = 20)	9 (45%)	11 (55%)
Gulu 2 (n = 20)	8 (40%)	12 (60%)
Gulu 3 (n = 20)	11 (55%)	9 (45%)
Gulu 4 (n = 15)	7 (46,6%)	8 (53,3%)
Gulu 5 (n = 30)	13 (43,3%)	17 (56,6%)

Kugawika kwa maguluwo kunali kwangozi. Odwala m'gulu lirilonse anali ofanana zaka, nthawi yayitali ya matenda, index ya thupi (BMI), ndi zizindikiro zina zingapo (tebulo 5).

Makhalidwe a odwala omwe amaphunzira

Kuunikira kwa ntchito yokonza mankhwalawa malinga ndi endoscopy kuwululira zotsatirazi. Odwala a magulu 1 ndi 2, kubwerezabwereza kwa eophaive esophagitis sikunachitike. Odwala a gulu lachitatu omwe ali ndi digiri yoyamba ya GERD, kuyambiranso kwamatendawa kwapezeka pambuyo pa miyezi itatu ndi isanu ndi umodzi mwa 44.4% ya milandu. Mu gulu la odwala 4, kubwerezabwereza kwa mawonekedwe osokoneza bongo omwe ali ndi endoscopy adapezeka mwa 7 odwala, omwe anali 87,5%. Odwala a gulu lolamulira, kuyambiranso kunawonedwa mu 100% ya milandu 6 miyezi itatha maphunzirowa atatha.

Kuunika kwa mphamvu yokonza mankhwalawa malinga ndi kuchuluka kwa zamankhwala

Mphamvu ya pafupipafupi ya kutentha kwamkati pakukonzanso mankhwala m'magulu osiyanasiyana imafotokozedwa mu Chithunzi 1-4.

Chithunzi 1 Mphamvu ya zizindikiro mwa odwala a gulu la 1 (Omez 20 mg tsiku lililonse)

Chithunzi 2 Mphamvu ya zizindikiro mwa odwala 2 (Omez 20 mg tsiku lililonse)