CLINDACIN CANDLE

Clindacin, kuphatikizapo monga yogwira pophika lincosamide mankhwala – clindamycinNdi mankhwala akumaloko omwe amagwiritsidwa ntchito ku matenda azachipatala gardnerellosis (vaginosis) yama bakiteriya. Makina a zochita zamtundu wa mankhwalawa mankhwala (kirimu, suppositories) cholinga chake ndikusokoneza njira za mapuloteni am'magazi a cell cell, omwe amapezeka pamlingo wa gawo lalikulu la 50S ribosomal subunit.

Zojambula zowonekera clindamycin zokwanira. Mlingo wapakatikati, mphamvu ya bacteriostatic ya mankhwala poyerekeza ndi ambiri tizilombo. Mlingo wapamwamba clindamycin yodziwika ndi bactericidal zochita zomwe zimapangitsa kuti ena awonongeke bacteria bacteria.

Ntchito yayikulu clindamycin zikuwonetsedwa tizilombokutsogoza mapangidwe bakiteriya vaginosiskuphatikiza: Mobiluncus spp. (mobilunkus) Gardnerella vaginalis (gardnerella vaginalis) Bacteroides spp. (ma bacteria) Peptostreptococcus spp. (peptostreptococcus) Mycoplasma hominis (mycoplasma hominis).

Osakhudzidwa ndi mawonekedwe clindamycin Zotupa Candida albicans (kukhumudwa) ndi Trichomonas vaginalis (ukazi trichomonias).

Intravaginal (mkati mwa nyini) jekeseni imodzi ya clindamycin pa mlingo wa 100 mg imatsogolera kupezeka kwa pafupifupi 4% ya mankhwala (pafupifupi 4 mg). Cmax ya plasma ya clindamycin ndi 20 ng / ml.

Zotsatira zoyipa

Odwala ena omwe amagwiritsidwa ntchito ndi clindacin adamva kukula kwa zoyipa zoyipa, kuphatikiza: kuyabwa mkati mwa nyinimaphunziro maculopapular zidzolozochitika urticariachitukuko khomo lachiberekero kapena colpita (vaginitis) vulvovaginal mkwiyokumverera kuyaka.

Kuchokera mu hematopoietic system nthawi zina, zotsatirazi zinaonedwa: thrombocytopeniachosintha leukopenia, eosinophilia, neutropenia, agranulocytosis.

Pankhani yofunika mayamwidwe a clindamycin, mawonetseredwe ake abwinobwino azotsatira zoyipa amatha kuphatikizira, kuphatikizapo pseudomembranous enterocolitis (zosowa kwambiri).

Clindacin zonona, malangizo ntchito

Kirimu ya Clindacin imapangidwira kuti idzagwiritse ntchito intravaginal pogwiritsa ntchito wapadera, wopanga nthawi imodzi wophatikizidwa mu zida zogulitsa mankhwala. Mlingo umodzi wotsekemera wa kirimu tsiku lililonse ndi 100 mg clindamycin (voliyumu yofunsira zonse). Kukhazikitsidwa kwa mankhwalawa kumachitika bwino madzulo (asanagone). Kutalika kwa nthawi ya maphunzirowa, monga lamulo, kumatenga masiku atatu mpaka 7.

Kugwiritsa ntchito

Kuti mupeze dosing yoyenera komanso yoyikiramo nthito mu nyini, tikulimbikitsidwa kugwiritsa ntchito omwe atayika omwe ali phukusi ndi mankhwalawo ndikutsatira njira yomwe amagwiritsa ntchito, yomwe ndi:

• Chotsani chophimba kuchokera ku chubu cha kirimu,
• sikani malo ogwiritsira ntchito pulasitiki otayika,
• Finyani chakumapeto kwa chubu kuti mudzaze wofunsayo (wopemphayo amadzazidwa kwathunthu pomwe piston yake yodziyimira payokha ikaima),
• wagona kumbuyo kwako, ikira woikapo nyini mozama momwe ungathere,
• mokani mokakamira wokopera pisitoni mpaka itasowa kanthu,
• Chotsani wogwiritsa ntchito nyini mosamala ndi kumachotsa.

Makandulo clindacin, malangizo ntchito

Clindacin suppositories amagwiritsidwanso ntchito kudzera mu intravaginally, limodzi ndi kasitomala kamodzi tsiku lililonse, makamaka madzulo (asanagone). Kutalika kwa nthawi ya maphunzirowa, monga lamulo, kumatenga masiku atatu mpaka 7.

Kuti mugwiritse ntchito moyenera mankhwalawo, supplementory imodzi imayenera kumasulidwa ku ma CD omwe akumata pokhapokha ndikudula filimu yoteteza kumaloko. Kenako, mu supine udindo, lowetsani zowonjezera mu nyini mwakuya momwe mungathere.

Kuchita

Akaphatikizidwa ndi clindamycin, mphamvu ya aminoglycosides imatheka.Streptomycin), Rifampicin ndi Gentamicin.

Clindamycin sagwirizana ndi Aminophylline, Erythromycin, Magnesium sulfate, Ampicillin, Kashiamu gluconatezotumphukira diphenylhydantoin ndi oyeserera.

Zotsatira za clindamycin zimachulukitsa kupuma kwa minofu chifukwa chowonekera n-anticholinergics.

Njira yogwiritsira ntchito

Makandulo Clindacin ntchito: intravaginally. Asanagwiritse ntchito, supplementory imodzi imamasulidwa ku ma CD a contour, mutatha kudula filimuyo pamtunda wa suppository, imayambitsidwa, ngati kuli kotheka, mkati mwa nyini, pamalo apamwamba.
1 suppository 1 nthawi patsiku, nthawi yomweyo asanagone kwa masiku 3-7 motsatana.

Kutulutsa mawonekedwe ndi kapangidwe kake ka mankhwala

Clindacin akupezeka mu mawonekedwe a supplementories kwa ukazi makina mu chithuza mapaketi atatu zidutswa katoni. Mankhwalawa amaphatikizidwa ndi malangizo atsatanetsatane.

Chofunikira chachikulu pa mankhwalawa ndi clindamycin phosphate, chilichonse chowonjezera chili ndi 100 mg ya chinthu ichi. Kuphatikizidwa kwa makandulo kumakhalanso ndi zinthu zingapo zothandiza.

Mankhwala

Clindacin ndi wa maantibayotiki kuchokera pagulu lincosamides. Changu chogwira ntchito cha mankhwalawa chikuwonetsa ntchito zochizira kwambiri poyerekeza ndi mitundu yambiri ya tizilombo toyambitsa matenda. Kuchita kwa mankhwalawa ndi bacteriostatic, ndiye kuti, clindamycin phosphate, yomwe ndi gawo la suppository, tikulepheretsa kukula ndi kubereka kwa maselo a pathogen patathogen poletsa kaphatikizidwe ka mapuloteni am'maselo ochepa.

Mankhwala amagwira ntchito motsutsana ndi staphylococci, streptococci, corynebacteria, mycoplasmas, peptococci, clostridia. Asanapereke mankhwala othandizira, mayi ayenera kupatsidwa ma bacteriological ndi bacterioscopic to secation kuti azindikire mphamvu ya pathogen ya antiotic.

Mankhwala amagwiritsidwa ntchito gynecological pochiza bakiteriya vaginosis yoyambitsidwa ndi tizinthu tating'ono tomwe timayang'ana ku clindamycin.

Contraindication

Asanayambe mankhwala ndi mankhwalawa, wodwalayo ayenera kukaonana ndi dokotala wa ana, kukayezetsa magazi ndikuwerenga mosamala malangizo omwe aphatikizidwa. Suppositories amatsutsana mwa odwala omwe ali ndi hypersensitivity kuti clindamycin kapena othandizira omwe amapanga mankhwala, amayi apakati komanso anthu omwe ali ndi vuto loipa la nyini.

Gwiritsani ntchito pa nthawi yoyembekezera komanso mkaka wa m`mawere

Munthawi yoyamba kubereka, mankhwalawa a Clindacin sanasankhidwe kulandira chithandizo kwa amayi omwe akuyembekezera. Izi ndichifukwa chosakwanira pazokhudzana ndi chitetezo cha clindamitacin pakukula kwa fetal, kuphatikiza apo, mu masabata 12 oyamba, ziwalo zonse ndi machitidwe a mwana wosabadwa zimapangidwa, ndipo mphamvu ya mankhwalawa imatha kukhudza njirayi.

Munthawi yachiwiri komanso yachitatu ya kutenga pakati, kugwiritsa ntchito mankhwala othandizira kumatheka pokhapokha malinga ndi kuyang'aniridwa ndi adokotala kuti chithandizocho chikhoza kukhala chothandiza kwambiri kwa mayi woyembekezera.

Zotsatira zoyipa

Mwambiri, mankhwalawa amalekeredwa bwino ndi odwala, komabe, mwa anthu omwe ali ndi vuto la chidwi la clindamitacin, zotsatirazi zotsatirazi zingakhale ndi izi:

• Pa mbali ya ziwalo zoberekera - kukula kwa yotupa njira ya khomo pachibelekeropo, vaginitis, colpitis,
• Kuchokera ku ziwalo za hemopoietic - kuchepetsa kuchuluka kwa leukocytes, neutropenia, eosinophilia, thrombocytopenia, agranulocytosis,
• Zomwe zimachitika mdelalo - kuwotcha, kuyabwa mu nyini, kupweteka ndi kusasangalala,
• Kuphatikizika kwa mankhwalawa kwa mankhwala kumakhala kochepa, koma nthawi zina kumatha kuyambitsa pseudomembranous enterocolitis.

Malangizo apadera

Mankhwalawa ndi mankhwala othandizira ku maliseche, tikulimbikitsidwa kupewa kugonana.

Popeza munthawi ya chithandizo cha mankhwala omwe mumalandira mwa mkazi, kumaliseche kwa mkazi kumalimbikitsidwa, mapiritsi aukhondo otetezedwa ayenera kuvalidwa kuti azikhala omasuka komanso aukhondo.

Pa msambo, mankhwala osokoneza bongo samachitika. Muyenera kudikirira mpaka masiku ovuta ndipo atangoyamba kumene chithandizo.

Pa mimba ndi mkaka wa m`mawere

Malinga ndi malangizo a boma, maphunziro azachipatala a chitetezo cha clindacin pamene mimba mu trimester yoyamba sizinachitike, mogwirizana ndi zomwe, kugwiritsa ntchito kwake panthawiyi sikuloledwa. Chithandizo cha Clindacin kwa akazi nthawi II ndi III trimester ya mimba Amaloledwa pokhapokha pakuwonjezera phindu la chithandizo chotere kwa mayi, poyerekeza ndi zovuta zomwe zingachitike chifukwa cha mwana wosabadwayo.

Ngakhale izi, mu gynecology pamakhala chizolowezi choika clindacin mkati II ndi III trimester ya mimbapopeza ena matenda obwera kumalisecheamafunikiradi chithandizo chotere. Poganizira za ndemanga za mankhwalawa mu mawonekedwe a kirimu, komanso ndemanga zama suppositories panthawi yomwe muli ndi nthawi imeneyi, ndikofunikira kudziwa kuti nthawi zambiri, chithandizo chamankhwala ndi Clindacin chinapangitsa kuti matenda opatsirana asachotserepo kanthu popanda zotsatira zoyipa kwa mayi woyembekezera ndi mwana wosabadwayo.

Kupatula kwa Mothandizidwa ndi Intravaginally clindamycin ndi mkaka wa mayi woyamwitsa sizinaphunzire, pokhudzana ndi, cholinga chake mu nthawi nyere zotheka pokhapokha poyerekeza zabwino za chithandizo chotere kwa mayi poyerekeza ndi zoopsa zomwe zingachitike kwa mwana wakhanda.

Ndemanga za Klindatsin

Amayi ambiri omwe amagwiritsa ntchito mankhwalawa mankhwalawa bakiteriya vaginosis, Ndimasiya ndemanga zabwino za suppindories a clindacin, kuphatikiza odwala omwe akukakamizidwa kuti ayambe kugwiritsa ntchito mankhwalawa mimba mu II ndi III trimester. Ndemanga za kirimu cha Klindacin sikuti ndizochulukirapo, komanso ndiwothandiza pankhani yothandiza ndi chitetezo cha mankhwalawa. Kufotokozera mwachidule momwe wodwala amasonyezera zamankhwala a Klindacin bakiteriya vaginosis, sichabwino kumuyambitsa kuti mugwiritse ntchito malinga ndi zisonyezo, koma pokhapokha mukaonana ndi katswiri.

Mtengo wa Klindatsin komwe ungagule

Poyerekeza ndi anzawo ogwiritsa ntchito zapakhungu (kuphatikizapo mafuta amkati, mafuta, ma suppositories, makapisozi, ndi zina), mtengo wa clindacin uli pamwambamwamba. Mwachitsanzo, mtengo Klindatsina mumakandulo N. 3 ndi ma ruble pafupifupi 650 (motero, makandulo 6 angagulidwe pa avareji kwa ma ruble 1300). Mtengo zonona Clindacin zimasiyanasiyana pakati pa ma ruble a 350-400 pa chubu 20 magalamu.

Zotsatira zoyipa

Dongosolo la genitourinary: kupweteka kwa kumaliseche, kuperewera kwa nyini, kusokonezeka kwa msambo, kusokonezeka kwamkati, dysuria, pyelonephritis, matenda a vaginitis / ukazi.

Thupi lonse: matenda a mafangasi, kupweteka kwam'mimba, kupweteka kwa mutu, kupweteka kwam'mimba, malungo, kupweteka m'mbali, kupweteka mthupi lonse, edema yodziwika bwino, candidiasis.

Matumbo: kusanza, kusanza, kutsekula m'mimba.

Khungu ndi mucous nembanemba: kuyabwa (osati pamalo a jakisoni), zotupa, kupweteka pamalo a jekeseni, kuyabwa (pamalo opangira jakisoni).

Gwiritsani ntchito pa nthawi yoyembekezera kapena mkaka wa m'mawere

Kugwiritsa ntchito kwapakati pa clindamycin phosphate suppositories mwa amayi apakati wachiwiri trimester ya mimba, komanso kagwiritsidwe ntchito ka clindamycin wachiwiri ndi wachitatu trimesters sikunayambitse zovuta zilizonse.

Mwa azimayi omwe ali ndi nthawi yoyamba kutenga pakati, mankhwalawa ayenera kugwiritsidwa ntchito pokhapokha ngati pali umboni wosatsutsika.

Sizikudziwika ngati clindamycin amuchotseredwa mkaka wa m'mawere pambuyo poti agwiritse ntchito clindamycin phosphate, chifukwa chake, panthawi yoyamwitsa, mankhwalawa amatha kuperekedwa pokhapokha phindu lomwe likuyembekezeka kwa mayi limayambitsa chiwopsezo cha mwana.

Ana sagwiritsa ntchito mankhwalawa.

Zolemba zogwiritsira ntchito

Kugwiritsa ntchito mankhwala owonjezera a vaginal okhala ndi clindamycin kungayambitse kukula kwa tizilombo tating'onoting'ono, kuphatikizapo yisiti.

Kugwiritsira ntchito pakamwa ndi makolo monga clindamycin kumatha kuyambitsa matenda otsegula m'mimba, ndipo nthawi zina - colitis. Ngati mukugwiritsa ntchito Mlingo wa mtundu wa clindamycin, kudzera m'matumbo am'mimba, matenda amtunduwu amayenera kuthetsedwa, njira zoyenera zodziwikirazi ziyenera kuchitika ndipo ayenera kulandira chithandizo ngati pakufunika kutero.

Odwala ayenera kuchenjezedwa kuti pochiza zowonjezera ziwalo zogonana zomwe zimakhala ndi clindamycin, munthu sayenera kulowa mkati mwa maliseche, komanso osagwiritsa ntchito mitundu ina ya mankhwala opangidwa ndi intravaginal management (mwachitsanzo, ma tampons, ma douches).

Chogulitsachi chili ndi zinthu zomwe zingachepetse mphamvu ya zopangira ma latex kapena mphira, monga makondomu kapena njira zakulera zachikazi. Chifukwa chake, kugwiritsa ntchito zinthu izi munthawi ya mankhwala ndi mankhwala osokoneza bongo

Pafupifupi 30% (6.5 - 70%) ya clindamycin imalowetsedwa mu systemic kufalitsidwa pambuyo pakugwiritsira ntchito zakudya zamafesi.