Glipizide - malangizo, ntchito, zikuchokera, zikuwonetsa

Imalimbikitsa kutulutsa kwa insulin kuchokera ku ma cell a yogwira pancreatic beta. Amachepetsa kuchuluka kwa hemoglobin ya glycosylated komanso kusala kudya kwa glucose mwa odwala omwe ali ndi mitundu komanso mitundu yambiri ya matenda osokoneza bongo omwe samadalira insulin. Kuchepetsa hyperglycemia pambuyo chakudya, kumawonjezera kulolerana kwa glucose komanso chilolezo chamadzimadzi aulere (pang'ono pang'ono). Kuyankha kwa insulinotropic kumayamba pakapita mphindi 30 kuchokera pakamwa, kutalika kwa nthawi limodzi ndi limodzi kumafikira maola 24. Sikuwakhudza ma lipid mawonekedwe am'magazi.

Poyeserera makoswe ndi mbewa zapamwamba nthawi 75 kuposa MPD, sizilimbikitsa carcinogeneis ndipo sizikhudza chonde (makoswe). Kafukufuku wachitika pa mabakiteriya, ndipo mu vivo , sanawululire katundu wa mutagenic.

Fomu yochita zinthu mwachangu imalowetsedwa mwachangu komanso mokwanira. Kudya sikukhudza mayamwidwe athunthu, koma kumachepetsa kwa mphindi 40. C_max mtima 1-3 mawola limodzi. T_1/2 ndi maola 2 - 2. Atatenga mawonekedwe a pang'onopang'ono, amawonekera m'magazi patatha maola 2-3, C_max Imafikiridwa pambuyo pa maola 6 - 12. Amalumikiza mapuloteni am'madzi ndi 98-99%. Kuchuluka kwa magawo pambuyo pa utsogoleri wa iv ndi 11 L, average T_1/2 - Maola 2-5. Chuma chonse atalandira jakisoni imodzi ya iv ndi 3 l / h. Biotransformed mu chiwindi (ndi gawo loyambirira - pang'ono). Zosakwana 10% zimachotsedwa mu mkodzo ndi ndowe, pafupifupi 90% imachotsedwa mu mawonekedwe a metabolites ndi mkodzo (80%) ndi ndowe (10%).

Zotsatira zoyipa za chinthu Glipizide

Kwa pang'onopang'ono mawonekedwe a glipizide:

Kuchokera wamanjenje ndi ziwalo zam'maganizo: chizungulire, kupweteka mutu, kugona tulo, kugona, kuda nkhawa, kusokonezeka, kusokonezeka, kupweteka kwamatenda, chithokomiro, kuphimba pamaso pa maso, kupweteka kwa maso, kupweteka kwa mtima.

Kuchokera pamtima ndi magazi (hematopoiesis, hemostasis): syncope, arrhythmia, ochepa matenda oopsa, kumva kutentha kwamphamvu.

Kuchokera kumbali ya kagayidwe: hypoglycemia.

Kuchokera mmimba: matenda a anorexia, nseru, kusanza, kumva kupsinjika mu epigastric dera, dyspepsia, kudzimbidwa, kuphatikizika kwa magazi mu chopondapo.

Pa khungu: zotupa, urticaria, kuyabwa.

Kuchokera pakapumidwe: rhinitis, pharyngitis, dyspnea.

Kuchokera ku genitourinary system: dysuria, watsika libido.

Zina: ludzu, kunjenjemera, zotumphukira edema, kupweteka kwapadera kwakanthawi mthupi, arthralgia, myalgia, kukokana, thukuta.

Mtundu wa glipizide:

Kuchokera wamanjenje ndi ziwalo zam'maganizo: mutu, chizungulire, kugona.

Kuchokera pamtima ndi magazi (hematopoiesis, hemostasis: leukopenia, agranulocytosis, thrombocytopenia, pancytopenia, hemolytic kapena aplastic anemia.

Kuchokera kumbali ya kagayidwe: matenda a shuga insipidus, hyponatremia, matenda a porphyrin.

Kuchokera mmimba: nseru, kusanza, kupweteka kwa epigastric, kudzimbidwa, cholestatic hepatitis (chikasu madontho a khungu ndi sclera, kusungunuka kwa chopondapo ndi kuzimiriritsa mkodzo, kupweteka kwa hypochondrium yoyenera).

Pa khungu: erythema, zotupa za maculopapular, urticaria, photosensitivity.

Zina: kuchuluka kwa ndende ya LDH, zamchere phosphatase, yosalunjika bilirubin.

Kuchita

Maminolo ndi glucocorticoids, amphetamines, anticonvulsants (hydantoin derivatives), katsitsumzukwa, baclofen, calcium antagonists, carbonic anhydrase inhibitors (epetepholamide), chlortalidone, njira yolerera pakamwa, epinephrine, ethacinic acid, giurimide, thymoside gland, triamteren ndi mankhwala ena omwe amayambitsa hyperglycemia. Anabolic steroids ndi androgens amalimbikitsa ntchito za hypoglycemic. Ma anticoagulants osadziwika, NSAIDs, chloramphenicol, clofibrate, guanethidine, Mao inhibitors, probenecid, sulfonamides, rifampicin kuwonjezera kuchuluka kwa gawo lamagazi m'magazi (chifukwa chakuchotsa mapuloteni a plasma) ndikuwonjezera mapangidwe a biotransfform. Ketonazole, miconazole, sulfinpyrazone block inactivation ndikuwonjezera hypoglycemia. Poyerekeza ndi zakumwa zoledzeretsa, kukulira kwa disulfiram-like syndrome (kupweteka kwam'mimba, nseru, kusanza, kupweteka mutu) ndikotheka. Mankhwala a Antithyroid ndi myelotoxic amawonjezera mwayi wokhala ndi agranulocytosis, wotsiriza, kuwonjezera - thrombocytopenia.

Bongo

Chithandizo: kusiya kwa mankhwala, kudya shuga ndi / kapena kusintha kwa zakudya ndi kuyang'aniridwa kwamatenda a glycemia, ndi vuto lalikulu la hypoglycemia (chikomokere, kukomoka) - kuchipatala, kuyamwa kwa 50% kulowetsedwa kwa shuga ndi kulowetsedwa munthawi yomweyo (iv drip) ya 10% yankho glucose kuti atsimikizire kuchuluka kwa shuga m'magazi pamwamba pa 5.5 mmol / l, kuwunika glycemia ndikofunikira pakatha masiku 1-2 wodwala atachoka. Kutsegula m'mimba sikothandiza.

Mtengo mumafakisi

Onani mtengo wa Glipizide mu 2018 ndi analogues zotsika mtengo >>> Mtengo wa Glipizide muma pharmacies osiyanasiyana ukhoza kusiyana kwambiri. Izi ndichifukwa chogwiritsa ntchito zinthu zotsika mtengo komanso mfundo zamtengo wapatali zamagulu azitsamba a pharmacy.

Werengani zambiri zokhudzana ndi mankhwala a Glipizid, malangizo ogwiritsira ntchito omwe amaphatikizapo zambiri ndi mtundu wa mankhwala. Lembali limaperekedwa pazokhudza zidziwitso zokha ndipo silingakhale cholowa m'malo mwa upangiri wa zamankhwala.

Zotsatira za pharmacological

Oral hypoglycemic wothandizira, yemwe amapezeka m'badwo wachiwiri. Imayendetsa katulutsidwe ka insulin ndi β-cell ya kapamba, kumawonjezera kutulutsidwa kwa insulin. Kuchulukitsa chidwi cha zotumphukira zimakhala kuti insulin. Ili ndi hypolipidemic, fibrinolytic kwenikweni, imalepheretsa kuphatikiza kwa maselo ambiri. Pambuyo pakukonzekera pakamwa, glipizide imathamanga mwachangu komanso kwathunthu kuchokera kumimba.
Kumangiriza kumapuloteni a plasma (makamaka okhala ndi albumin) ndi 98-99%.
Wopangidwira m'chiwindi. Zosakwana 10% zimachotsedwa mu mkodzo ndipo ndowe sizinasinthidwe, pafupifupi 90% imachotsedwa mu mkodzo (80%) komanso ndowe (10%) monga metabolites.

Njira yogwiritsira ntchito

Kwa akuluakulu: Ikani payekhapayekha kutengera ndi chithunzi cha matenda. Mlingo woyambirira ndi 2.5-5 mg 1 nthawi / tsiku 15-30 mphindi musanadye chakudya cham'mawa. Ngati ndi kotheka, mlingo umatha pang'onopang'ono (pang'onopang'ono) ndi 2,5-5 mg / tsiku. Mlingo watsiku ndi tsiku wopitilira 15 mg uyenera kugawidwa pawiri.
Mlingo waukulu: umodzi - 15 mg, tsiku lililonse - 40 mg.

- Type 2 shuga mellitus (osadalira insulin) odwala omwe ali ndi kunenepa kwambiri kapena owonjezera thupi pogwiritsa ntchito mankhwala osagwira.

Zambiri pazambiri

Glipizide ndilo dzina lalikulu logulitsa la mankhwala omwe ali ndi dzina lomweli, koma ndi gawo la mankhwala ena.

Gawoli limadziwika ndi kutchulidwa kwa hypoglycemic, komwe kumachitika chifukwa cha mphamvu yake m'maselo a pancreatic. Zotsatira zake ndizogwira insulin.

Thupi limayimiriridwa ndi ufa woyera wopanda fungo lotchulidwa. Sichimadziwika ndi solubility m'madzi kapena mowa. Gawo lake limalumikizana ndi mapuloteni amwazi, kusinthidwa kukhala metabolites. Excretion imachitika ndi impso.

Glipizide imapangidwa m'mapiritsi okhala ndi zinthu zomwe zili 5 ndi 10 mg. Zothandizira zothandizira zimatha kukhala zosiyanasiyana kutengera dzina la mankhwalawo.

Zotsatira zoyipa

- Kuchokera ku endocrine system: kawirikawiri - hypoglycemia (makamaka okalamba, odwala ofooka, kudya kosakhazikika, kumwa mowa, kusokoneza chiwindi ndi impso).
- Kuchokera pamimba: kukhumudwa, kutsegula m'mimba, kawirikawiri - chiwopsezo cha hepatitis.
- Kuchokera kwa hemopoietic dongosolo: nthawi zina - thrombocytopenia, leukopenia, agranulocytosis.
- Thupi lawo siligwirizana: kawirikawiri - zotupa pakhungu, kuyabwa.
- Zina: mutu.

Malangizo ogwiritsira ntchito

Mankhwalawa akupangidwira kuthana ndi matenda a shuga a 2, ngati njira zosagwiritsa ntchito mankhwalawa sizibweretsa zotsatira.

Mapiritsiwo amatengedwa pakamwa, asanadye kaye, ndimankhwala otsukidwa ndi madzi. Mlingo umatengera umunthu wa wodwala. Nthawi zambiri amalimbikitsidwa kuti ayambe ndi kutumikiridwa kwa 5 mg patsiku.

Ndi osakwanira bwino komanso kulolerana kwabwino, mulingo ungathe kuwonjezeka pang'onopang'ono mpaka 15 mg tsiku lililonse. Amaloledwa kumwa mankhwalawa nthawi, mutha kugawa maudindo osiyanasiyana.

Nthawi zina, mlingo wa Glipizide uyenera kuchepetsedwa. Chifukwa chake, chithandizo sichiyenera kuyamba popanda kuvomerezedwa ndi katswiri - popanda chidziwitso chachipatala ndizovuta kwambiri kuyesa mawonekedwe a chithunzi cha chipatala.

Kudumpha mapiritsi ndikosayenera, koma izi zikachitika, musatenge pawiri.

Contraindication ndi zomwe zingavulaze

Ngakhale zabwino za mankhwalawa chifukwa cha matenda ashuga, pali zochitika pamene kugwiritsidwa ntchito kwake ndikuloletsedwa.

Zoyimbira zazikulu za Glipizide zimaphatikizapo:

• tsankho pakuchokera,
• shuga ketoacidosis
• wodwala matenda ashuga
• mimba
• kudya kwachilengedwe
• mtundu 1 shuga
• othandizira opaleshoni
• kuvulala kwambiri
• malungo.

Kuletsa kugwiritsa ntchito mankhwalawa kumachitika chifukwa cha chiwopsezo cha zotsatira zoyipa zomwe zingachitike.

Pakati pawo amatchulapo:

• mutu
• chizungulire
• kutopa,
• kugona
• zosautsa mtima
• chisokonezo,
• nkhawa
• conjunctivitis
• kupweteka m'maso
• zotupa m'mimba,
• kuphwanya kwamkati,
• nseru
• urticaria
• kuyabwa
• zotupa pakhungu,
• rhinitis
• kukakamizidwa
• arrhasmia,
• yafupika libido
• thukuta kwambiri
• hypoglycemia.

Zambiri mwa kuphwanya izi sizowopsa, koma zimabweretsa zovuta. Ena amatha kupangitsa kuti wodwalayo afe ngati sanapatsidwe chithandizo. Chifukwa chake, musanagwiritse ntchito mankhwala omwe ali ndi glipizide, muyenera kufunsa dokotala kuti mudziwe momwe mungamwere molondola. Koma ngakhale ngati mankhwalawo adalangizidwa ndi katswiri, muyenera kuyang'anira bwino moyo wanu. Kuzindikira zizindikiro zoyipa ndi chifukwa chofunsira thandizo.

Mankhwala omwe amafunsidwa sakuvomerezeka kuti agwiritsidwe ntchito. Ngati pali ma contraindication, ndikofunikira kusintha m'malo mwake ndi china, ndikumapangidwa kosiyana.

Mwa zina zazikulu za Glipizide zimatha kutchedwa:

1. Glibenclamide. Mankhwala amadziwika ndi hypoglycemic effect, yomwe imatheka chifukwa cha zomwe zili m'munsi mwake. Izi zikutanthauza kuti Minidiab ndi mndandanda wokwanira wa mapiritsi omwe amawaganizira kuti akupangidwa, ndipo malangizo ake ndi ofanana. Mankhwalawa ndi amodzi mwa okwera mtengo, muyenera kulipira ma ruble pafupifupi 1,500 pakulongedza.
2. Metformin. Chothandizira chake ndi mankhwala a metformin. Zimasokoneza ntchito yogwira shuga ndi chiwindi, komanso zimakulitsa chiwopsezo cha minofu kuti insulin. Mankhwala akugulitsidwa monga mapiritsi ndi mtengo wa ma ruble 90-105.
3. Maninil. Maziko a mankhwalawa ndi glibenclamide. Kutulutsidwa kwake kudzakhala kotsutsana mwa mawonekedwe a piritsi. Kuphatikiza pa hypoglycemic, imakhala ndi mtima komanso antiarrhythmic athari. Mtengo umasiyana kuchokera ku ma ruble 95 mpaka 120.
4. Glucophage. Chofunikira chake chachikulu ndi metformin. Mankhwalawa ali ndi mawonekedwe a piritsi, omwe amapangidwira pakamwa. Imakhala ndi chibadwa chathu. Zogulitsidwa malinga ndi zomwe katswiri wazopanga zimachita pamtengo wokwana ma ruble 120.
5. Glidiab. Ichi ndi chinanso chamagulu omwe ali ndi chinthu chomwechi. Zimalimbikitsa kapangidwe ka insulin mthupi, potero kuchepetsa magazi. Mtengo wake ndi ma ruble 100-120.

Kanema kuchokera kwa katswiri:

Mankhwala onsewa amatha kuyambitsa mavuto, owopsa kwambiri omwe ndi hypoglycemia. Amakhalanso ndi zotsutsana. Chifukwa chake, muyenera kuwagwiritsa ntchito pokhapokha mwachilolezo kwa dokotala komanso malingana ndi malangizo. Saloledwa kusankha nokha mankhwala omwe mungapange nokha, zitha kukhala zowopsa.

Kutulutsa Fomu

Mapiritsi a 0.005 g (5 mg) phukusi la 30 zidutswa.

Zomwe zili patsamba lomwe mukuwona zimapangidwa kuti zidziwitso zokha komanso sizimalimbikitsa kudzipatsa mankhwala mwanjira iliyonse. Chidacho chimapangidwa kuti chizolowere akatswiri azachipatala kuti awonjezere zambiri zamankhwala ena, potero amawonjezera luso lawo. Kugwiritsa ntchito mankhwala osokoneza bongo Glipizide mosakayikira limapereka mwayi wofunsana ndi katswiri, komanso malingaliro ake pa njira yogwiritsira ntchito ndi kuchuluka kwa mankhwala omwe mumasankha.

Mtengo, ndemanga ndi fanizo

Popeza glipizide ndichinthu chogwira ntchito, mankhwala ambiri okhala ndi zoterezi amatha kupezeka pamsika wa Russia. Mwachitsanzo, Glucotrol CL ndi Glibenez Retard. Kutengera mtundu wa kumasulidwa, mtengo wa mankhwalawa Glucotrol CL umachokera ku rubles 280 mpaka 360, ndi Glibenez Retard - kuchokera ku ruble 80 mpaka 300.

Ndemanga za anthu ambiri odwala matenda ashuga omwe adamwa mankhwalawa ndizokhutiritsa. Komabe, ambiri adazindikira kuti achire zotsatira za glipizide zimatsika pakapita nthawi, chifukwa chake nthawi zambiri zimagwiritsidwa ntchito limodzi ndi mankhwala ena a matenda ashuga. Mwa zabwino za mankhwalawa amatha kusiyanitsidwa mosavuta ndikugwiritsa ntchito mitengo yokhulupirika ya mankhwala omwe ali ndi glipizide.

Mu milandu ngati mankhwala amodzi sangakhale oyenera chifukwa chophatikizana kapena kusachita bwino, dokotala amakupatsani analogue. Mankhwalawa akuphatikizapo:

Popanda kuvomerezedwa ndi dokotala, kudzipereka nokha sikofunika. Kukonzekera komwe kumakhala ndi glipizide kumatha kukhala osokoneza thupi. Mukamagwiritsa ntchito moyenera mankhwalawa, mutha kusintha kuchuluka kwa shuga ndikuchotsa zizindikiro za matenda ashuga. Komanso sitiyenera kuyiwala zamankhwala olimbitsa thupi a shuga ndi zakudya zoyenera.

Mu kanema munkhaniyi, adokotala azikambirana za mankhwala osokoneza bongo.