Aprovel, mapiritsi 150 mg, 14 ma PC.

Chonde, musanagule Aprovel, mapiritsi a 150 mg, 14 ma PC., Onani zambiri za nkhaniyi ndi zomwe zili patsamba lawebusayiti la wopanga kapena tchulani mtundu wina ndiomwe amayang'anira kampani yathu!

Zomwe zikuwonetsedwa patsamba lino sizoperekedwa pagulu. Wopangayo ali ndi ufulu wosintha kapangidwe kake, kapangidwe kake ndi katengedwe ka katundu. Zithunzi zamalonda pazithunzi zomwe zaperekedwa pamndandanda wazomwe zili patsamba lino zimasiyana ndi zomwe zidachokera.

Zambiri pamutengo wa zinthu zomwe zawonetsedwa pamndandanda wa masamba tsambalo zingasiyane ndi zenizeni panthawiyo yokhazikitsa dongosolo la zomwe zikugwirizana.

Zotsatira za pharmacological

Famu yazapulogalamu: angiotensin II receptor blocker.
Machitidwe a Aprovel ndi antihypertensive mankhwala, osokoneza bongo a angiotensin II receptors (mtundu wa AT1).
Irbesartan ndi wamphamvu, wogwira ntchito akagwiritsidwa ntchito molingana ndi angiotensin II receptor antagonist (mtundu wa AT1). Zimalepheretsa zovuta zonse za angiotensin II, zodziwika kudzera ma receptors a mtundu wa AT1, mosasamala za gwero lake kapena kapangidwe ka kaphatikizidwe ka angiotensin II. Mphamvu yotsutsana ndi angiotensin II (AT1) receptors imabweretsa kuchuluka kwa plasma kwa renin ndi angiotensin II komanso kuchepa kwa plasma mozama a aldosterone. Mukamagwiritsa ntchito Mlingo woyenera wa mankhwalawa, ma seramu ambiri a ioni a potaziyamu sasintha kwambiri. Irbesartan sichimaletsa kininase-II (angiotensin-kutembenuza enzyme), mothandizidwa ndi momwe kupangidwira kwa angiotensin II komanso kuwonongeka kwa bradykinin kwa metabolites yogwira ntchito. Mwa chiwonetsero cha zochita za irbesartan, kuyambitsa kwake kwa metabolic sikofunikira.
Irbesartan amachepetsa kuthamanga kwa magazi (BP) posintha pang'ono pamtima. Mukamamwa Mlingo mpaka 300 mg kamodzi patsiku, kuchepa kwa magazi kumadalira mlingo, komabe, ndi kuchuluka kwina kwa irbesartan, kuchuluka kwa hypotensive kumakhala kochepa.
Kutsika kwakukulu kwa kuthamanga kwa magazi kumatheka ndi maola 3-6 atatha kumwa, ndipo antihypertensive zotsatira zimapitirira kwa maola osachepera 24. Maola 24 mutatenga Mlingo wa irbesartan, kuchepa kwa kuthamanga kwa magazi ndi 60-70% poyerekeza ndi kuyankha kwakukulu kwa mankhwalawo kuchokera kumbali ya diastolic ndi systolic magazi. Mukamamwa kamodzi patsiku muyezo wa 150-300 mg, kuchuluka kwa kuchepa kwa magazi pofika kumapeto kwa nthawi ya interdose (mwachitsanzo, maola 24 mutatha kumwa mankhwalawa) m'malo wodwala atagona kapena atakhala pafupifupi pa 8-13 / 5-8 mm RT .art. (systolic / diastolic blood pressure) ndichopambana kuposa cha placebo.
Kumwa mankhwala osokoneza bongo a 150 mg kamodzi patsiku kumayambitsa kuyankha komweku kwa antihypertensive (kutsitsa magazi osadwala musanadye mlingo wotsatira wa mankhwalawa komanso kuchepa kwa kuthamanga kwa magazi m'maola 24) monga kumwa mlingo womwewo wogawidwa pamtundu wambiri.
The hypotensive zotsatira za mankhwala Aprovel amakula mkati mwa masabata 1-2, ndipo pazotheka achire kwambiri zimatheka patadutsa masabata a 4-6 atayamba chithandizo. Mphamvu ya antihypertensive motsutsana ndi maziko a chithandizo cha nthawi yayitali ikupitirirabe. Pambuyo pakuleka kulandira chithandizo, kuthamanga kwa magazi pang'onopang'ono kumabwereranso ku mtengo wake woyambirira. Mankhwala atathetsedwa, palibe matenda achire.
Kugwiritsa ntchito bwino kwa mankhwalawa Aprovel sikudalira zaka komanso jenda. Odwala a mpikisano wa Negroid samvera kwenikweni Aprovel motor tiba (monga mankhwala ena onse omwe amakhudza dongosolo la renin-angiotensin-aldosterone).
Irbesartan sichikhudza seramu uric acid kapena kwamikodzo ya uric acid.
Pharmacokinetics: Pambuyo pakukonzekera pakamwa, irbesartan imatengedwa bwino, tanthauzo lake lonse la bioavailability lili pafupifupi 60-80%. Kudya nthawi yomweyo sikuti kumakhudza kwambiri bioavailability wa irbesartan.
Kuyankhulana ndi mapuloteni a plasma pafupifupi 96%. Kulumikizana ndi ma cell a magazi ndi kochepa. Kuchuluka kwa magawa ndi malita 53-93.
Pambuyo pakukonzekera pakamwa kapena makina a 14C-irbesartan, 80-85% ya kufalikira kwa plasma imachitika mu irbesartan yosasinthika. Irbesartan imapangidwa ndi chiwindi ndi makutidwe ndi okosijeni ndi glucuronic acid. Oxidation ya irbesartan imachitika makamaka mothandizidwa ndi cytochrome P450 CYP2C9, kutenga nawo gawo kwa isoenzyme CYP3A4 mu metabolism ya irbesartan ndikosathandiza. Metabolite yayikulu mu kayendedwe kazinthu ndi irbesartan glucuronide (pafupifupi 6%).
Irbesartan ali ndi mzere wowerengeka komanso wofanana ndi mankhwalawa pamlingo waukulu kuchokera pa 10 mpaka 600 mg, pa mlingo womwe umaposa 600 mg (muyeso womwe umalimbikitsa mlingo wambiri), kinetics ya irbesartan imakhala yosagwirizana (kuchepa kwa mayamwidwe). Pambuyo pakukonzekera pakamwa, kuchuluka kwa plasma kumachitika pambuyo pa maola 1.5-2. Chilolezo chokwanira ndi impso ndi 157-176 ndi 3-3.5 ml / min., Mwapadera. Hafu yotsiriza ya moyo wa irbesartan ndi maola 11-15. Ndi kumwa kamodzi tsiku lililonse, kuchuluka kwa plasma ndende (Css) kumachitika patatha masiku atatu. Pogwiritsa ntchito irbesartan tsiku lililonse kamodzi patsiku, kuchuluka kwake kwamadzi m'magazi (osakwana 20%) kumadziwika. Amayi (poyerekeza ndi abambo) amakhala ndi mozama kwambiri plasma wozungulira irbesartan. Komabe, zosiyana zokhudzana ndi jenda m'miyoyo yaumoyo ndi kudzikundikira kwa irbesartan sizikupezeka. Kusintha kwa mankhwala a Irbesartan mwa akazi sikofunikira. Makhalidwe a AUC (dera lomwe lili pansi pa nthawi ya pharmacokinetic curve) ndi Cmax (pazipita plasma concentration) ya irbesartan odwala okalamba (zaka ≥65) ndizokwera pang'ono poyerekeza ndi odwala omwe ali ndi zaka zochepa, komabe, theka la moyo wawo womaliza sasiyana kwambiri. Kusintha kwa Mlingo kwa okalamba sikofunikira.
Irbesartan ndi metabolites ake amachotsedwa m'thupi, onse ndi ndulu ndi mkodzo. Pambuyo pakamwa kapena pakhungu la 14C-irbesartan, pafupifupi 20% yama radioac imapezeka mkodzo, ndi ena onse mu ndowe. Osakwana 2% ya mlingo womwe umayendetsedwa umatulutsidwa mu mkodzo ngati irbesartan yosasinthika.
Kuwonongeka kwa impso: Odwala omwe ali ndi vuto la impso kapena odwala omwe akudwala hemodialysis, ma pharmacokinetics a irbesartan sasintha kwambiri. Irbesartan samachotsedwa m'thupi nthawi ya hemodialysis.
Kuchepa kwa chiwindi ntchito: Odwala matenda a chiwindi omwe amakhala ofatsa kapena okhazikika, mapiritsi a pharmacokinetic a irbesartan sasintha kwambiri. Kafukufuku wa Pharmacokinetic mwa odwala omwe ali ndi chiwindi chachikulu cha hepatic sanachitike.

• Chofunikira pa matenda oopsa
• Nephropathy ndi ochepa matenda oopsa ndi mtundu 2 shuga mellitus (monga mbali antihypertensive mankhwala).

Zotsatira zoyipa

M'maphunziro olamulidwa ndi placebo (odwala 1965 adalandira irbesartan), zotsatirazi zotsatirazi zidadziwika.
Kuchokera kumbali ya chapakati mantha dongosolo: nthawi zambiri - chizungulire.
Kuchokera pamtima wamtima: nthawi zina - tachycardia, kutentha kwamphamvu.
Kuchokera pakupuma dongosolo: nthawi zina - chifuwa.
Kuchokera pamatumbo am'mimba: nthawi zambiri - nseru, kusanza, nthawi zina - matenda am'mimba, dyspepsia, kutentha kwa mtima.
Kuchokera pakubala: nthawi zina - kukanika pogonana.
Pa thupi lonse: kutopa kwambiri, nthawi zina kupweteka pachifuwa.
Kumbali ya zowonetsa zasayansi: nthawi zambiri - kuwonjezereka kwa KFK (1.7%), osatsatiridwa ndi mawonetseredwe am'thupi a musculoskeletal system.
Odwala ochepa matenda oopsa ndi mtundu 2 shuga mellitus ndi microalbuminuria yachilendo aimpso ntchito, orthostatic chizungulire ndi orthostatic hypotension amaonedwa mu 0.5% ya odwala (nthawi zambiri kuposa ndi placebo). Odwala omwe ali ndi matenda a shuga mellitus omwe ali ndi magazi okwera kwambiri omwe ali ndi microalbuminuria ndi ntchito yachilendo, a hyperkalemia (oposa 5.5% mmol / L) amapezeka mu 29.4% ya odwala omwe ali mgululi amalandira 300 mg irbesartan ndi 22% ya odwala omwe ali mgulu la placebo.
Odwala omwe ali ndi matenda oopsa omwe ali ndi matenda a shuga, kuperewera kwa impso komanso 2% ya odwala, zotsatirazi zina zowonjezera zimadziwika (nthawi zambiri kuposa ndi placebo).
Kuchokera kumbali ya chapakati mantha dongosolo: nthawi zambiri - chizungu.
Kuchokera pamtima dongosolo: Nthawi zambiri - orthostatic hypotension.
Kuchokera ku minculoskeletal system: nthawi zambiri - kupweteka m'mafupa ndi minofu.
Kumbali ya magawo a labotale: hyperkalemia (oposa 5.5% mmol / l) amapezeka 46.3% ya odwala omwe ali mgululi omwe amalandila irbesartan, komanso mu 26.3% ya odwala omwe ali mgulu la placebo. Kutsika kwa hemoglobin, komwe sikunali kofunika kwambiri m'magazi, kunawonedwa mu 1.7% ya odwala omwe amalandila irbesartan.
Zotsatira zotsatirazi zidawonekeranso panthawi yotsatsa:
Thupi lawo siligwirizana: kawirikawiri - zotupa, urticaria, angioedema (monga ena angiotensin II receptor antagonists).
Kuchokera kumbali ya kagayidwe: kawirikawiri - hyperkalemia.
Kuchokera kumbali ya chapakati mantha dongosolo: kawirikawiri - mutu, kulira m'makutu.
Kuchokera pamatumbo am'mimba: kawirikawiri - dyspepsia, kusokoneza chiwindi, chiwindi.
Kuchokera ku minculoskeletal system: kawirikawiri - myalgia, arthralgia.
Kuchokera kwamikodzo dongosolo: kawirikawiri - matenda opatsirana aimpso (kuphatikiza milandu yolephera ya impso odwala omwe atenga pang'onopang'ono).

Malangizo apadera

Mochenjera, Aprovel ayenera kutumikiridwa kwa odwala omwe ali ndi vuto la mafupa a m'mitsempha chifukwa cha chiopsezo cha kuthana kwambiri kwa vuto lakelo komanso kulephera kwa aimpso.
Asanaikidwe mankhwala Aprovel mankhwalawa okodzetsa kwambiri Mlingo zingayambitse kuchepa magazi ndipo kumawonjezera chiopsezo cha hypotension koyambirira kwa chithandizo ndi Aprovel. Odwala osowa madzi kapena odwala omwe ali ndi vuto la kuchepa kwa sodium ayoni chifukwa chothandizidwa kwambiri ndi okodzetsa, kuletsa mchere wambiri kuchokera ku chakudya, kutsekula m'mimba kapena kusanza, komanso kwa odwala omwe akudwala hemodialysis, kusintha kwa mlingo panjira yochepetsera ndikofunikira.
Zotsatira za maphunziro oyesera
Kafukufuku wochitidwa pa nyama yothandizira, mutagenic, clastogenic, ndi carcinogenic zotsatira za Aprovel sizinakhazikitsidwe.
Kugwiritsa Ntchito Kwa Ana
Chitetezo ndi kufunika kwa mankhwalawa kwa ana sichinakhazikitsidwe.
Kukopa pa kuyendetsa magalimoto ndi kayendedwe kazinthu
Palibe chomwe chikuwonetsa kuti atenge Aprovel pa kuyendetsa magalimoto kapena makina.