Atomax: malangizo ogwiritsira ntchito, analogi, mtengo, ndemanga

Atomax amatanthauza mankhwala-statins a m'badwo wachitatu, omwe ali ndi lipid-kuchepetsa. Ndi mpikisano wosankha wa HMG-CoA reductase, ma enzyme omwe amathandizira kuchepetsa kuphatikizira kwa cholesterol synthesis.

Kugwiritsa ntchito mankhwalawa ndizothandiza mankhwalawa a hypercholisterinemia komanso kukweza kwa thyroglobulin (TG). Chifukwa cha Atomax, lipid metabolism imatha kukhala yofanana komanso zovuta zoyipa za cholesterol yapamwamba zitha kupewedwa.

Munkhaniyi mutha kupeza zambiri zamankhwala a Atomax, malangizo, magwiritsidwe, mtengo, ndemanga za odwala ndi zina zofananira.

Kutulutsa mawonekedwe ndi kapangidwe kake

Atomax ndi mankhwala omwe cholinga chake kupondereza HMG-CoA reductase, kuchititsa kuchepa kwa kaphatikizidwe ka cholesterol m'maselo a chiwindi. Mosiyana ndi maumboni a m'badwo woyamba, Atomax ndi mankhwala opangira zinthu.

Pa msika wa pharmacological mutha kupeza mankhwala opangidwa ndi kampani ya India HeteroDrags Limited ndi mbewu zapakhomo za Nizhfarm OJSC, Skopinsky Pharmaceutical Plant LLC.

Atomax imapezeka mu mawonekedwe a mapiritsi oyera omwe ozungulira mawonekedwe ake ndi mbali zotsikira. Kuchokera kumwamba amakutidwa ndi nembanemba wa filimu. Phukusi limodzi lili ndi miyala 30.

Piritsi imaphatikizapo 10 kapena 20 mg ya yogwira - atorvastatin calcium calcium.

Kuphatikiza pa gawo lalikulu, piritsi lililonse ndi chigamba chake chimakhala ndi kuchuluka kwake:

• sodium croscarmellose,
• oyeretsa talcum ufa
• lactose mfulu
• magnesium wakuba,
• wowuma chimanga
• calcium carbonate
• povidone
• silicon dioksidi madzi achilengedwe
• crospovidone
• triacetin

Kuphatikiza apo, kuchuluka kwa titanium dioxide kumaphatikizidwa pokonzekera.

Limagwirira zake kanthu yogwira ntchito

Monga tanenera kale, zotsatira za kuchepa kwa lipid-atoma ya Atomax zimatheka chifukwa choletsa kuchepa kwa HMG-CoA. Cholinga chachikulu cha enzyme iyi ndikusintha methylglutaryl coenzyme A kukhala mevalonic acid, womwe ndi patsogolo pa cholesterol.

Atorvastatin imagwira maselo a chiwindi, kutsitsa kuchuluka kwa LDL ndi cholesterol kupanga. Amagwiritsidwa ntchito moyenera ndi odwala omwe ali ndi homozygous hypercholesterolemia, omwe sangathe kuthandizidwa ndimankhwala ena omwe amachepetsa cholesterol. Mphamvu yakuchepa kwa cholesterol ndende mwachindunji zimatengera mlingo wa chinthu chachikulu.

Atomax simalimbikitsidwa kuti imwedwa pakudya, monga kudya kumachepetsa kuchuluka kwa mayamwidwe. Chosakaniza chophatikizacho chimayamwa bwino m'mimba. Zambiri mwa atorvastatin zimawonedwa patatha maola 2 mutatha kugwiritsa ntchito.

Mothandizidwa ndi michere yapadera CY ndi CYP3A4, kagayidwe kamapezeka m'chiwindi, zomwe zimapangitsa kuti parahydroxylated metabolites ipangidwe. Kenako metabolites amachotsedwa m'thupi limodzi ndi bile.

Zizindikiro ndi contraindication ntchito mankhwala

Atomax imagwiritsidwa ntchito kutsitsa cholesterol. Dotolo amakupatsani mankhwala osakanikirana ndi zakudya zopezeka ndi matenda enaake monga matenda oyamba, achibale komanso achibale osagwirizana ndi a hypercholesterolemia.

Kugwiritsa ntchito mapiritsi kumathandizanso pakuwonjezera kuchuluka kwa seramu ya thyroglobulin (TG), pamene chithandizo chamankhwala sichimabweretsa zotsatira zomwe mukufuna.

Atorvastatin bwino amachepetsa cholesterol mwa odwala homozygous achiberekera hypercholesterolemia, pamene sanali mankhwala pharmacological ndi zakudya sakhazikitsa metabolid kagayidwe.

Atomax ndi yoletsedwa m'magulu ena a odwala. Malangizo omwe ali ndi mndandanda wa contraindication ogwiritsira ntchito mankhwalawa:

1. Ana ndi achinyamata ochepera zaka 18.
2. Nthawi yobereka mwana ndi kuyamwitsa.
3. Hepatic kukanika kwa komwe sikudziwika.
4. Hypersensitivity pazinthu zomwe zimapangidwa.

Mankhwala amathandizidwa mosamala ngati ochepa hypotension, kusagwirizana kwa ma elekitirodiya, vuto la endocrine, chiwindi cham'mimba, zakumwa zoledzeretsa komanso khunyu, zomwe sizingatheke.

Malangizo ogwiritsira ntchito mankhwalawa

Chofunikira pakuthandizira kwa Atomax ndiko kusunga zakudya zapadera. Chakudya chopatsa thanzi ndicholinga chofuna kuchepetsa zakudya zomwe zimakhala ndi cholesterol yayikulu. Chifukwa chake, chakudyacho sichimaphatikizapo kumwa kwa viscera (impso, ubongo), mazira a mazira, batala, mafuta a nkhumba, etc.

Mlingo wa atorvastatin umasiyana 10 mpaka 80 mg. Monga lamulo, adotolo amakupatsani mankhwala ochepa a 10 mg patsiku. Pali zinthu zingapo zomwe zimapangitsa kuchuluka kwa mankhwalawa, monga kuchuluka kwa LDL ndi cholesterol yathunthu, zolinga zamankhwala ndikuchita kwake.

Kuchulukitsa kwa mankhwalawa kumatha kuchitika pambuyo pa masiku 14 mpaka 14. Poterepa, kuphatikizira kwa lipids m'madzi amadzi amwazi kumakhala kofunikira.

Pambuyo masiku 14 chithandizo, kuchepa kwa cholesterol kumawonedwa, ndipo patatha masiku 28 pazotheka kwambiri achire. Ndi chithandizo chotenga nthawi yayitali, lipid metabolism imabweleranso.

Kukhazikitsa kwa mankhwalawa kuyenera kusungidwa pamalo otetezedwa kuti asayang'anitsidwe ndi dzuwa mwachindunji ndi ana aang'ono. Mphamvu yotentha yosungirako imasiyanasiyana madigiri 5 mpaka 20 Celsius.

Moyo wa alumali ndi zaka ziwiri, atatha nthawi imeneyi mankhwalawo saloledwa kumwa.

Zovuta Zoopsa komanso Mankhwala Osokoneza bongo

Kudzilamulira nokha kwa mankhwala osokoneza bongo ndi koletsedwa.

Nthawi zina, mankhwala amathandizanso wodwala kusintha.

Musanagwiritse ntchito Atomax, muyenera kufunsa dokotala.

Tsamba lophunzitsira limafotokoza za zotulukapo zoyipa izi:

• Kusokonezeka kwa chapakati mantha dongosolo: asthenic syndrome, kugona tulo kapena kugona, kugona tulo, amnesia, chizungulire, kupweteka kwa mutu, kupsinjika, tinnitus, mavuto okhala pogona, paresthesia, zotumphukira neuropathy, kukoma kwa pakamwa.
• Zochita zogwirizana ndi ziwalo zam'maganizo: Kukula kwa ugonthi, malo owuma a conjunctiva.
• Mavuto a mtima ndi hematopoietic dongosolo: phlebitis, magazi m'thupi, angina pectoris, vasodilation, orthostatic hypotension, thrombocytopenia, kuchuluka kwa mtima, arrhasmia.
• Kuwonongeka kwa kwam'mimba kokwanira ndi dongosolo la biliary: kudzimbidwa, kutsegula m'mimba, mseru, kusanza, kupweteka kwam'mimba, chiwindi colic, kuyimitsa, kutentha kwa mtima, kuwonjezeka kwa mpweya, kupweteka kwapakhosi.
• Khungu limakhudza khungu: kuyabwa, zotupa, chikanga, kutupa kwa nkhope, mawonekedwe a dzuwa.
• Mavuto a minofu ndi mafupa am'mimba: minofu kukokana kwa m'munsi, kupweteka kwa kuphatikizika kwa mafupa ndi msana, myositis, rhabdomyolysis, nyamakazi, kukokomeza kwa gout.
• Kuchepetsa kukodza: ​​Kuchepetsa kukodza, cystitis.
• Kuzindikira kwa magawo a labotale: hematuria (magazi mkodzo), albuminuria (mapuloteni mu mkodzo).
• Zina zomwe zimachitika: hyperthermia, kuchepa kwa chilakolako chogonana, kusokonekera kwa mankhusu, alopecia, thukuta kwambiri, seborrhea, stomatitis, kutaya magazi mkamwa, thumbo, ukazi ndi mphuno.

Kutenga Mlingo waukulu wa atorvastatin kumawonjezera chiopsezo cha kulephera kwa impso, komanso myopathy (neuromuscular matenda) ndi rhabdomyolysis (kwambiri degree of myopathy).

Mpaka pano, palibe mankhwala apadera a mankhwalawa.

Ngati zizindikiro za bongo zimachitika, ziyenera kuchotsedwa. Pankhaniyi, hemodialysis siyothandiza.

Kuchita ndi mankhwala ena

Zomwe zimagwiritsidwa ntchito ndi mankhwala zimatha kudzichitira mosiyanasiyana, chifukwa chomwe achire atomax angalimbikitsidwe kapena kufooka.

Kuthekera kwa kulumikizana pakati pazigawo zosiyanasiyana za mankhwala osiyanasiyana kumafuna kuti wodwalayo adziwitse adokotala za kumwa mankhwala omwe amakhudza ntchito ya Atomax.

Mu malangizo ogwiritsira ntchito mankhwala a hypolipidemic, mumakhala chidziwitso chokwanira pakukhudzana ndi mankhwala ena.

1. Mankhwala osakanikirana ndi cyclosporine, erythromycin, ma fibrate ndi ma antifungal agents (gulu la azoles) limawonjezera chiopsezo cha neuromuscular pathology - myopathy.
2. Popanga kafukufuku, kutumiza kwa munthawi yomweyo kwa Antipyrine sikumabweretsa kusintha kwakukulu mu pharmacokinetics. Chifukwa chake, kuphatikiza kwa mitundu iwiri ya mankhwala ndikuloledwa.
3. Kugwiritsanso ntchito komwe kuyimitsidwa komwe kumakhala ndi magnesium hydroxide kapena aluminium hydroxide kumabweretsa kuchepa kwa zomwe atorvastatin mu plasma.
4. Kuphatikizidwa kwa Atomax ndi mankhwala oletsa kubereka komwe kumakhala ndi kachilomboka ndi norethindrone kumawonjezera AUC pazinthu izi.
5. Kugwiritsa ntchito pamodzi nthawi yomweyo colestipol kumachepetsa kuchuluka kwa atorvastatin. Izi zimathandizanso kutsitsa kwa lipid.
6. Atomax imatha kuwonjezera digoxin m'magazi. Ngati ndi kotheka, chithandizo ndi mankhwalawa chiyenera kuyang'aniridwa ndi achipatala.
7. Kufanana kwa Azithromycin sikukhudza zomwe zimachitika mu Atomax m'magazi amwazi.
8. Kugwiritsidwa ntchito kwa erythromycin ndi clarithromycin kumapangitsa kuchuluka kwa atorvastatin m'magazi.
9. Panthawi yoyeserera pachipatala, panalibe mankhwala omwe adapezeka pakati pa Atomax ndi Cimetidine, Warfarin.
10. Kuwonjezeka kwa msika wogwira ntchito kumawonedwa ndi kuphatikiza kwa mankhwalawo ndi ma proteinase blockers.
11. Ngati ndi kotheka, dokotala amakulolani kuphatikiza Atomax ndi mankhwala, omwe akuphatikizapo Amplodipine.
12. Kafukufuku wokhudzana ndi momwe mankhwalawa amathandizira ndi antihypertensive mankhwala sanachitike.

Ndi kuphatikiza kwa Atomax ndi estrogens, palibe zoyipa zomwe zimawonedwa.

Mtengo, ndemanga ndi fanizo

Pali zambiri zazidziwitso pakugwiritsa ntchito Atomax pa intaneti. Chowonadi ndi chakuti pakali pano, ma IV a statins omwe amagwiritsidwa ntchito pochita zachipatala. Mankhwalawa amakhala ndi mlingo waukulu ndipo samayambitsa mavuto ambiri.

Atomax ndizovuta kugula m'masitolo am'dzikolo chifukwa choti tsopano siigwiritsidwe ntchito. Pafupifupi, mtengo wa phukusi (mapiritsi 30 a 10 mg) umachokera ku 385 mpaka 420 rubles. Ngati ndi kotheka, mankhwalawa atha kuitanidwa pa intaneti pa tsamba lovomerezeka la opanga.

Pali ndemanga zochepa pazomwe zimapangitsa kuti ma lipid azitsitsa pazosankha zawo. Nthawi zambiri, amalankhula za zomwe zimachitika ndikamamwa mankhwala. Komabe, pali malingaliro osiyanasiyana.

Chifukwa cha zovuta zosiyanasiyana komanso zovuta zina, nthawi zina dokotalayo amapereka mankhwala ofanana (mankhwala omwe ali ndi chinthu chomwechi) kapena analogue (yopangidwa ndi zigawo zosiyanasiyana, koma imatulutsa njira yofananira).

Maulumikizano otsatirawa a Atomax atha kugulidwa pamsika wogulitsa mankhwala ku Russia:

• Atovastatin (No. 30 pa 10 mg - 125 rubles),
• Atorvastatin-Teva (No. 30 kwa 10 mg - 105 ma ruble),
• Atoris (No. 30 kwa 10 mg - 330 ma ruble),
• Liprimar (No. 10 pa 10 mg - 198 rubles),
• Novostat (No. 30 kwa 10 mg - 310 ma ruble),
• Tulip (Na. 30 kwa 10 mg - 235 ma ruble),
• Torvacard (No. 30 kwa 10 mg - 270 rubles).

Mwa mitundu yofananira ya Atomax, ndikofunikira kusiyanitsa mankhwalawa:

1. Akorta (No. 30 kwa 10 mg - 510 rubles),
2. Krestor (No. 7 kwa 10 mg - 670 rubles),
3. Mertenil (No. 30 kwa 10 mg - 540 rubles),
4. Rosuvastatin (No. 28 pa 10 mg - 405 rubles),
5. Simvastatin (No. 30 pa 10 mg - 155 rubles).

Popeza taphunzira mosamala mankhwala a Atomax, malangizo ogwiritsira ntchito, mtengo, analogi ndi lingaliro la ogula, wodwalayo, pamodzi ndi katswiri wopezekapo, atha kuwunika mozama za kufunika kwa kumwa mankhwalawo.

Zambiri zokhudzana ndi ma statins zimaperekedwa kanema munkhaniyi.

Kuphatikizika, mawonekedwe omasulidwa

Zomwe zimagwira mu Atomax ndi atorvastatin. Ntchito yothandiza imachitidwa ndi calcium carbonate, shuga mkaka, cellulose, croscarmellose sodium, povidone K-30, magnesium stearate, hypromellose, talc, titanium dioxide, triacetin.

Atomax - mapiritsi oyera okutidwa ndi mphako kuti athe kugawanitsa. Mitundu iwiri ya mankhwalawa imapangidwa ndi zinthu zogwira 10 kapena 20 mg.

Zotsatira za pharmacological

Mfundo za atorvastatin zimatengera luso lake lolepheretsa ntchito za HMG-CoA reductase. Enzyme iyi imayambitsa gawo limodzi mwa magawo oyamba a cholesterol synthesis. Kamodzi m'thupi, Atomax imalepheretsa kaphatikizidwe ka sterol, ndikupangitsa kutsika kwake. Kuti alipire vuto la kuchepa kwa cholesterol, kuphwanya kwa lipoproteins "zovulaza", zomwe zimakhala ndizofunikira, zimayambitsa. Nthawi yomweyo, thupi limathandizira kaphatikizidwe ka "good" high-density lipoproteins (HDL), omwe amachititsa kuti sterol iperekedwe kuzinthu zowononga.

Zosintha mu kuchuluka kwa cholesterol, lipoproteins imalepheretsa kukula kwa atherosulinosis, komanso matenda okhudzana ndi - stroke, kugunda kwamtima, necrosis yamapeto.

Kuchuluka kwa atorvastatin m'magazi kumachitika mkati mwa maola 1-2 pambuyo pa kuperekedwa. Kutha kutsekereza kumatenga maola 20-30. Mankhwala amachotseredwa ndi chiwindi, ochepa ndi mkodzo. Izi zimathandiza kuti Atomax akhazikitsidwe mavuto a impso, koma amafunika kugwiritsa ntchito mosamala odwala omwe ali ndi vuto la chiwindi.

Mankhwala

Mankhwala ndi kutchulidwa hypolipidemic kwenikweni. Makina ochitapo kanthu amatengera luso lake losankha mpikisano poletsa HMG-CoA reductase - puloteni yayikulu pakusintha methylglutaryl coenzyme A mu mevalonic acidzokhudzana ndi zotsogola zam'mbuyomu, kuphatikizapo cholesterol. TG ndi cholesterol mu chiwindi chimaphatikizidwa ndi VLDL, kenako zimalowa m'magazi ndipo zimatengedwa kupita nazo zimakhala. Kupitilira apo, VLDL imapangidwa kuchokera ku VLDL, yomwe, ikamalumikizana ndi LDL receptors, imapangidwira.

Chida chandamale atorvastatin ndi chiwindi ndipo mwachindunji momwe amapangira cholesterol ndi chilolezo cha LDL. Atomax amachepetsa kaphatikizidwe cholesterol ndikuchepetsa kuchuluka kwa tinthu ta LDL. Mankhwala ndi othandiza kwa odwala homozygous hypercholesterolemiasingagwiritsidwe ntchito ndi mankhwala ena ochepetsa lipid. Mlingo wa mankhwalawa amasankhidwa payekha poganizira zochizira, chifukwa mphamvu zakuchepa cholesterol imagwirizana kwambiri ndi mankhwala.

Pharmacokinetics

Atomax amatengeka bwino m'matumbo, kudya zakudya kumachepetsa mayamwidwe. Cmax - pafupifupi 2 maola, bioavailability pa 30%, chifukwa cha chidziwitso kagayidwe kachakudya mankhwala pa "gawo loyamba" mu mucosa wam'mimba ndi chiwindi.

Amapangidwa ndi ma enzymes CYP3A4 5 ndi CY m'chiwindi kuti apange parahydroxylated metabolitesndi mkulu mankhwala. Imafukusidwa mu ndulu pambuyo pakuchepa kwa hepatic. T1 / 2 pafupifupi maola 15.

Zizindikiro zogwiritsidwa ntchito

• Pofuna kuchepetsa chonse cholesterol (kuphatikiza ndi zakudya) odwala omwe ali ndi pulayimale hypercholesterolemiabanja losakhala la banja komanso banja losokonekera hypercholesterolemia,
• Kuchuluka kwa seramu TG odwala omwe mankhwalawo amadya
• Pofuna kuchepetsa milingo yonse cholesterol Odwala omwe ali ndi homozygous achiberekero hypercholesterolemia, ndi kulephera kwa zakudya mankhwala ndi sanali mankhwala

Contraindication

Kuzindikira kwakukulu kwa Atomax, matenda a chiwindi osachokera kwina, azaka zosaposa 18, mimbanyere. Chenjerani ndi odwala omwe ali ndi vuto lalikulu la electrolyte, ochepa hypotension, endocrine matenda, chiwindi matenda, ndi aakulu uchidakwaosalamulirika khunyu.

Zotsatira zoyipa

Asthenic syndromekamwa yowuma kugonakapena kusowa tulo, chizungulire, amnesia, mutuzolota paresthesiazotumphukira neuropathy, kutengeka mtima, kukhumudwa, chisokonezo cha pogona, tinnitus, kusokonekera kwa kukoma, ugonthi, kupweteka kowuma, palpitations, kupweteka pachifuwa, orthostatic hypotension, kuchepa magazi, phlebitis, Vasodilation, thrombocytopeniamphuno kutsegula m'mimba/kudzimbidwa, bronchitis, arrhythmiamagazi m`kamwa hepatic colic, chisangalalokugona, nseru, kutentha pa chifuwa, kapambakusanza kwam'mimba stomatitismagazi otupa myositismiyendo kukokana, kupweteka kwa msana, mgwirizano wamkati, rhabdomyolysis, nyamakazi, albinuriayafupika libido cystitis, thukuta, seborrhea, hematuriakukhetsa magazi mu maliseche kusabalakhungu loyera, kulemera kwake, khungukuchuluka gout, chikanga, alopecia, kutupa kwa nkhopekusungika kwamikodzo zithunzikuchuluka kwa thupi kutentha.

Malangizo a Atomax ogwiritsira ntchito (Njira ndi Mlingo)

Chithandizo cha Atomax chikuyenera kuchitika motsutsana ndi maziko zakudya zokhala ndi lipidkupitilira nthawi yonse ya chithandizo. Mlingo umachokera ku 10-80 mg. Pafupifupi, mlingo woyambirira ndi 10 mg ndipo amatengedwa nthawi imodzi patsiku, mosasamala kanthu za kudya. Mlingo wa mankhwalawa amasankhidwa kwa wodwala pamlingo cholesterol/ LDL, zolinga zamankhwala ndikuthandizira kwamankhwala. Kumayambiriro kwa mankhwalawa komanso kuwonjezeka kwa Mlingo wa Atomax, ndikofunikira kuwongolera zomwe zili zam'magazi m'magazi amtundu uliwonse wa 2-3 ndikusintha mlingo.

The achire zotsatira kuwonekera osati kale 2 milungu, ndipo pazipita - pambuyo 4 milungu, amene ndi kugwiritsa ntchito mankhwalawa amasungidwa bwino.

Atomax: Zizindikiro zogwiritsidwa ntchito

Malinga ndi malangizo, Atomax imalembedwa kwa odwala omwe ali ndi:

• chachikulu hypercholesterolemia, heterozygous mabanja, osakhala achibale hypercholesterolemia,
• Hyperlipidemia
• hypertriglyceridemia,
• dbetalipoproteinemia.

Atomax imathandiza kupewa mavuto a atherosulinosis odwala omwe ali ndi matenda amitsempha yamagazi. Amawerengera anthu omwe ali pachiwopsezo chokhala ndi matenda amtima wapamtima malinga ndi zinthu ziwiri kapena zingapo: kusuta, kunenepa kwambiri, ukalamba, kuperewera kwa zakudya m'thupi, moyo wopanda ntchito.

Njira ya ntchito, Mlingo

Atomax imayikidwa kokha ngati chowonjezera pazakudya, ngati sizinathandize. Iyenera kuonedwa panthawi yonse ya chithandizo.

Mukamatenga statin, muyenera kutsatira malamulo osavuta. Imwani piritsi la Atomax nthawi imodzi, nthawi 1 / tsiku, ndi madzi ambiri. Sizingathe kutafunidwa, kuphwanyidwa.

Chithandizo chimayamba ndi mlingo wocheperako. Ndimayang'ana kwambiri kusintha kwa cholesterol, lipoproteins, adokotala amatha kusintha mlingo pambuyo masabata 2-4. Mlingo wololedwa wambiri ndi 80 mg. Ngati kuchuluka kwa atorvastatin sikugwira ntchito, Atomax imasinthidwa ndi statin yamphamvu kwambiri kapena mankhwala ena ochepetsa mafuta m'thupi omwe amaphatikizidwa pakulandila.

Kwa odwala ambiri okhala ndi hypercholesterolemia, komanso hyperlipidemia yosakanikirana, 10 mg ya mankhwalawa ndi yokwanira.

Anthu omwe ali ndi homozygous achibale a hypercholesterolemia amamwa mankhwalawa 80 mg katatu / tsiku (20 m'mawa, 20 masana, 40 madzulo). Monga lamulo, izi ndizokwanira kutsitsa cholesterol ndi 18-45%.

Chenjezo liyenera kugwiritsidwa ntchito popereka Atomax kwa odwala omwe:

• kumwa mowa kwambiri
• anali ndi matenda a chiwindi
• kudwala kagayidwe kachakudya, vuto la mahomoni, khunyu, hypotension, mafupa am'mitsempha,
• ndi zochulukirapo kuchitapo kanthu.

Atomax: malangizo ogwiritsira ntchito, mtengo, ndemanga, analogi

Atomax ndi mankhwala ochepetsa mphamvu ya lipid omwe ali m'gulu la achire a HMG-CoA reductase inhibitors.

Amagwiritsidwa ntchito kuchepetsa kuchuluka kwa apolipoprotein B, cholesterol yathunthu, triglycerides, LDL ndi VLDL kwa odwala omwe ali ndi vuto lalikulu la hypercholesterolemia, achibale komanso osagwirizana ndi achibale a hyperlipidemia odwala a dysbetalipoproteinemia 3s 3 level 3 triple mphamvu ya chakudya. Iwo contraindicated vuto la mkulu chiwindi michere, hypersensitivity, mkaka wa m`mawere, yogwira chiwindi pathologies, pakati ndi ana.

Kufotokozera ndi kapangidwe

Atomax ndi piritsi lozungulira la biconvex lomwe limakutidwa ndi filimu yoyera. Kukhazikika pamtunda kumaloledwa.

Piritsi 1 ili ndi 10 mg kapena 20 mg ya atorvastatin.

• titanium dioxide
• crospovidone
• magnesium wakuba,
• povidone
• sodium croscarmellose,
• talcum ufa
• colloidal anhydrous silika,
• lactose
• kukhuthala
• primellose 15 CPS.

Kwa akuluakulu

Atomax imalembedwa kwa odwala akuluakulu omwe ali ndi mikhalidwe monga:

• Kuchepetsa kuchuluka kwa cholesterol, triglycerides, apolipoprotein B, LDL ndi VLDL kwa odwala omwe ali ndi hypercholesterolemia, omwe siabanja komanso achibale a heterozygous hypercholesterolemia,
• Chithandizo cha odwala akudwala seramu triglycerides ndi dysbetalipoproteinemia (pakalibe zotsatira zoyenera za mankhwala).

Atomax imatsutsana mwa ana ndi achinyamata osakwana zaka 18.

Kuchita ndi mankhwala ena

Chiwopsezo cha myopathy munthawi ya mankhwala ndi mankhwala ena a mkalasiyi chimachulukana ndikugwiritsa ntchito cyclosporine, erythromycin, fibrate, antifungals.

Ndi kuphatikiza kwa atorvastatin ndi erythromycin kapena clarithromycin, kuchuluka kwa atorvastatin mu seramu yamagazi kunadziwika.

Kugwiritsa ntchito pamodzi kwa atorvastatin ndi proteinase inhibitors kumayendera limodzi ndi kuchuluka kwa serum atorvastatin.

Malangizo apadera

Asanayambe chithandizo ndi Atomax, wodwalayo ayenera kupereka zakudya zoyenera za hypocholesterol, zomwe ayenera kutsatira pakumwa.

Kugwiritsa ntchito ma HMG-CoA reductase inhibitors kuti muchepetse zamadzimadzi am'magazi kungapangitse kusintha kwa magawo amomwe amomwe amachititsa ntchito ya chiwindi.

Zotsatira zoyipa pakuyendetsa magalimoto sizinatchulidwe, komabe, chifukwa cha zovuta zoyambira, kusamala kuyenera kuchitika mukamachita zinthu zomwe zitha kukhala zoopsa.

Malo osungira

Atomax iyenera kusungidwa kuchokera kwa ana, pamalo owuma, yotetezedwa ndi dzuwa. Kutentha kosungira - osaposa 25 ° С.

Moyo wa alumali ndi zaka 2.

Kugwiritsa ntchito mankhwala Atomax sikuti kumapereka chiwonetsero chofanana kwa onse odwala. Motere, pamsika wamankhwala pali mankhwala ena othandiza chimodzimodzi.

Mertenil

Mertenil ndi kusankha komanso kupikisana kwa HMG-CoA reductase. Mankhwalawa amatulutsa mphamvu yotsatsira lipid.

Mertenil amalembera hypertriglyceridemia, hypercholesterolemia, kuphatikiza dyslipidemic, komanso kupewa koyambilira kwa mtima. Mankhwalawa ali ndi zotsutsana zambiri komanso zoletsa kugwiritsa ntchito.

Musanayambe chithandizo, ndikulimbikitsidwa kuti mulumikizane ndi achipatala kuti mukaonane ndi dokotala.

Atotex

Atotex ndi mankhwala ochepetsa mphamvu ya lipid okhala ndi atorvastatin monga gawo logwira ntchito. Amagwiritsidwa ntchito pazomwezo monga mankhwala a Atomax. Atotex ndi yoletsedwa kugwiritsidwa ntchito panthawi yoyembekezera, yoyamwitsa, kunyalanyaza kulera ndi odwala omwe ali ndi zaka zapakati, vuto la chiwindi, kusalolera komanso osakwana zaka 18.

Tulip

Mankhwala Tulip ndi amodzi a pharmacological angapo a kusankha (osankha) opikisana a HMG-CoA reductase.

Amagwiritsidwa ntchito pochiza hypercholesterolemia, kuphatikiza kwa Hyperlipidemia, komanso ngati chinthu china choperekera chakudyacho kuti athetse homozygous ndi heterozygous Famer hypercholesterolemia.

Ndi zoletsedwa kwa hypersensitivity, yogwira chiwindi, kuperewera kwa chiwindi, pakati, kuyamwitsa, kuchuluka kwa chiwindi michere yosadziwika, osanyalanyaza kugwiritsa ntchito njira zakulera zapakati pa odwala a msinkhu wobereka komanso machitidwe a ana.

Livazo

Chomwe chimagwira ndi calcium pitavastatin. Hypolipidemic mankhwala.

Zisonyezero pakugwiritsa ntchito Livazo zikuphatikiza ma maupanga awa: kuchepa kwa LDL ndi VLDL, triglycerides, cholesterol yathunthu ndi apolipoprotein B motsutsana ndi banja la heterozygous dibo pulayimale hypercholesterolemia ndi mitundu yosakanikirana ya dyslipidemia. Contraindication ndi zofanana ndi zomwe zidagwiritsidwa ntchito kale ndi mankhwala.

Vasilip

Mankhwala ochepetsa lipid pang'onopang'ono monga mapiritsi okhala ndi simvastatin ngati chinthu chogwira ntchito.

Amawerengera ngati chowonjezera chakudya chapadera cha matenda oyamba kapena achibale (homozygous) hypercholesterolemia, hypertriglyceridemia, dyslipidemia wosakanikirana, komanso prophylactic ya mtima pathologies odwala omwe ali ndi vuto la ubongo. Mankhwala Vasilip ndi oletsedwa kwa matenda a chiwindi (kuphatikizapo kuchuluka kwa transaminases), mkaka wa m'mimba, pakati, pakati pa ana osakwana zaka 18.

Achikachik

Mapiritsi a Lovagexal ali ndi gawo limodzi lovastatin. Mankhwala ndioyenera kugwiritsa ntchito ngati kuli kofunika kutsitsa LDL, triglycerides, VLDL ndi cholesterol yathunthu m'magazi ndi hypertriglyceridemia ndi hypercholesterolemia yoyambira.

Mankhwala Lovagexal ali contraindicated kuti ana osaposa zaka 12, odwala matenda aimpso kapena kwa chiwindi, komanso ambiri woopsa thupi.

Munthawi ya bere ndi kuyamwitsa, mankhwalawa sanaikidwe.

Mtengo wa Atomax uli pa avareji kuyambira pa 81 mpaka 390 rubles.

Mphamvu ya mankhwala Atomax motsutsana cholesterol

Odwala amafunsa kuti atenge bwanji Atomax pa cholesterol? Kuti mukhale ndi lingaliro la mankhwalawa, muyenera kudziwa cholinga chake, mtundu wake, momwe zimakhudzira.

Ngati munthu ali ndi kuchuluka kapena kuchepa kwa chinthu chilichonse mthupi, izi zimatha kubweretsa vuto m'machitidwe ena. Kuti mubwezeretse, mankhwalawa amagwiritsidwa ntchito, imodzi mwa njira zawo.

Ndi cholesterol, Atomax imapereka chithandizo chothandiza kwambiri.

Momwe mungatenge Atomax ndi cholesterol?

Mankhwalawa ali ngati mapiritsi. Mmbali zawo ndizowoneka bwino, pamwamba pake kali. Kumbali imodzi pali ngozi. Ali ndi chipolopolo chosungunuka, amadziwika ndi mtundu woyera. Mapiritsiwo ali ndi matuza, omwe amasindikizidwa mu bokosi lamkati lamkati.

• chogwira ntchito (chigawo chachikulu), chomwe ndi atorvastatin,
• wowuma chimanga
• calcium carbonate
• lactose
• povidone
• sodium croscarmellose,
• silicon
• anhydrous colloidal dioxide,
• crospovidone.

Kodi chigamba cha mapiritsi chimapangidwa ndi chiyani? Kuchokera pa triacetin, talc yoyeretsedwa, primmeloza, titanium dioxide.

Momwe mungamwe Atomax, malangizo ogwiritsira ntchito omwe ali m'mapaketi, aliyense ayenera kudziwa. Ichi ndi mankhwala ochepetsa lipid, zomwe zimapangitsa kuti muchepetse cholesterol, yomwe imakhudza thupi la munthu.

Zili m'gulu la ma statins. Komanso, mankhwalawa ndi mpikisano wosankha wa HMG-CoA reductase. Amapangidwanso kuti agwire ntchito ina: kutsitsa ma lipoproteins a plasma.

Atomax imakhala ndi phindu pa otsika kachulukidwe lipoprotein padziko maselo a chiwindi.

Zotsatira zamankhwala, kuwonjezeka kodziwika kwa zochitika za LDL receptors kumawonedwa. Ndikofunikira kudziwa kuti kuchepetsedwa kwa chiwopsezo chokhala ndikuchepetsa zovuta za ischemia.

Mankhwalawa alibe mphamvu iliyonse yokhudza thupi.

Kodi kudikira zotsatira? Kuti muwone zosintha zabwino, muyenera kumwa mapiritsi osachepera milungu iwiri. Mankhwalawa ayenera kugwiritsidwa ntchito mwezi umodzi kuyambira chiyambi cha mankhwala. Maphunzirowa atatha, zotsatira zake ziziwoneka kwa nthawi yayitali.

Zizindikiro zogwiritsidwa ntchito. Atomax ndi zotchulidwa monga:

1. Cholesterol yayikulu.
2. Kuchulukitsa kwa LDL-C.
3. Kuwonjezeka kwa thyroglobulin ndi apolipropylene B.
4. Ngati mulingo wa seramu TG ukuwonjezeka.
5. Mu nkhani pamene dysbetalipoproteinemia amakula.

Atomax siyothandiza ngati wodwala satsata zakudya zapadera zomwe adokotala amuuzidwa. Mankhwalawa ndi othandizira ndipo amagwira ntchito molumikizana ndi zakudya zapadera.

Momwe mungatenge ndikuti Mlingo wa mankhwalawa? Asanayambe maphunziro, wodwalayo asinthane ndi zakudya zapadera za lipid. Madokotala amalimbikitsa Mlingo aliyense payekha kwa wodwala aliyense. Mankhwalawa amatha kumwa onse asanadye, pambuyo, komanso asanadye nthawi iliyonse masana. Kugwiritsa ntchito bwino kwa mankhwalawa sikuchepa.

Kodi Atomax amagwirizana bwanji ndi mankhwala ena? Zomwe mankhwalawa akagwiritsidwa ntchito limodzi ndi erythromycin kapena antifungal agents, zotsatira zoyipa za mawonekedwe a myopia zimatha kuchitika. Atomax sayenera kugwiritsidwa ntchito molumikizana ndi kuyimitsidwa komwe kumakhala ndi hydroxide mu aluminium, apo ayi, kuyika kwa atorvastatin m'magazi kumachepa komanso mphamvu yothandizira, motero.

Terfenadine angagwiritsidwe ntchito, chifukwa mankhwalawa omwe amafunsidwa masiku ano sasintha zomwe anali nazo kale. Itha kugwiritsidwa ntchito ndi estrogens - palibe choopsa chomwe chidzachitike.

Sichikutsutsana ndi Warfarin ndi Cimetidine.

Osagwiritsa ntchito ndi proteinase inhibitors, popeza kuphatikiza uku kumawonjezera kuchuluka kwa ntchito ya Atomax. Ndikofunikira kupatula zoletsa, kapena kuchepetsa mlingo. Izi zikuyenera kuchitika moyang'aniridwa ndi madokotala.

Atomax ndiye mdani wa cholesterol!

Anthu nthawi zina amatha kuwona kuchepa kapena kuwonjezeka kwa magwiridwe antchito ena omwe amakhala mthupi ndipo amatenga nawo gawo pogwira ntchito machitidwe osiyanasiyana ndi ziwalo zamkati.

Komabe, pakuwonjezeka kwa kuchuluka kwa zinthu monga cholesterol, nthawi zambiri kumabweretsa kukula kwa matenda osiyanasiyana.

Kuti mubwezeretse, komanso kupewa kuti pakhale zovuta zingapo, Atomax imagwiritsidwa ntchito nthawi zambiri.

Mankhwalawa amapereka chithandizo chothandiza kwambiri.

Pofuna kupewa kuwoneka ngati mavuto, ndikofunikira kutsatira malangizo a dokotala.

1. Malangizo ogwiritsira ntchito

Atomax ndi mankhwala ochepetsa lipid omwe ali m'gulu la ma statins. Ndi osokoneza mpikisano wosankha wa HMG-CoA reductase wokhudzidwa ndi kutembenuka kwa ma 3-hydroxy-3-methylglutaryl coenzyme A kupita ku mamolekyulu a mevalonic acid. Cholinga chake ndi kutsitsa cholesterol, komanso lipoprotein ya plasma.

Izi ndichifukwa choti kuletsa kwa HMG-CoA reductase kumachitika, ndipo kapangidwe ka cholesterol m'maselo a chiwindi amachepetsa.

Kuphatikiza apo, mankhwalawa amakhudza kuwonjezeka kwa kuchuluka kwa ma LDL pama cell a chiwindi, potero amalimbikitsa kukhathamira ndikutsata kwotsatira kwa mankhwala a LDL.

Zotsatira zake, pali kuwonjezereka kowonjezereka kwa zochitika za LDL receptors. Komanso, mofananamo, chiopsezo chotheka cha zovuta zingapo za ischemic chimachepetsedwa.

Tiyenera kudziwa kuti mankhwalawa alibe mutagenic kapena carcinogenic amakhudza thupi la munthu.

Zotsatira zakuchulukirachulukira zochiritsika zitha kuonekera patatha pafupifupi milungu iwiri mutayamba kumwa mapiritsiwo. Zotsatira zazikulu zimawonedwa pakatha mwezi umodzi, kenako zimapitilira kwa nthawi yayitali.

Chizindikiro chovomerezeka

Mapiritsi a Atomax tikulimbikitsidwa kuti atengedwe kuti achitire bwino matenda ngati awa:

1. Kuchulukitsa kwa LDL-C.
2. Kukwezedwa kwathunthu mafuta m'thupi.
3. Kuchulukitsa kwa TG, komanso apolipoprotein B.
4. Zowonjezera za HDL-C zomwe zimatsagana ndi hypercholesterolemia, kuphatikiza hyperlipidemia, heterozygous osakhala banja kapena banja.
5. Kuchulukitsa kwa seramu TG.
6. Kukula kwa dysbetalipoproteinemia.

Atomax iyenera kumwa ngati mankhwala owonjezera kutengera zapadera zakudya zakudya.

Njira yoyendetsera ndi kumwa

Asanayambe chithandizo ndi mankhwalawa, wodwalayo ayenera kutsatira zakudya zomwe zimachepetsa lipid.

Mlingo woyambira wabwino ndi 10 mg kamodzi tsiku lililonse. Ngati ndi kotheka, ikhoza kuwonjezeka mpaka 80 mg kamodzi patsiku. Kumwa mankhwalawa sikudalira nthawi yatsiku, komanso kudya.

Odwala omwe ali ndi hyperlipidemia yosakanikirana kapena hypercholesterolemia nthawi zambiri amapatsidwa mlingo womwe umaposa 10 mg kamodzi patsiku.

3. Zochita Zamankhwala

Mogwirizana ndi mapiritsi a Atomax ndi mankhwala osiyanasiyana:

1. Kuphatikiza mankhwala ogwiritsira ntchito "Erythromycin", "Cyclosporin", mafupa osiyanasiyana, komanso mankhwala antifungal omwe ali a azole gulu la mankhwala, zimawonjezera chiwopsezo cha chitukuko cha myopathy.
2. Kugwiritsanso ntchito komwe kuyimitsidwa, komwe kumaphatikizapo aluminium hydroxide kapena magnesium hydroxide, ndi chifukwa chakuchepa kwa kuchuluka kwa mankhwala omwe amapezeka m'magazi am'magazi.
3. Kuphatikizika kwa Atomax ndi Antipyrine sikuti kumabweretsa kusintha kwakufunika kwamankhwala omaliza. Chifukwa chake, zitha kuphatikizidwa ndi mankhwala omwe ali ndi mawonekedwe ofanana.
4. Chifukwa chophatikizidwa ndi "Colestipol," kuchepa kwa kuchuluka kwa atorvastatin komwe kumachitika m'madzi amwazi kumaonedwa. Pankhaniyi, kusintha kwa lipid-kutsitsa kwenikweni.
5. Imatha kuwonjezera kwambiri kuchuluka kwa "Digoxin" m'madzi a m'magazi. Chifukwa chake, ndi chithandizo chotere, ndikulimbikitsidwa kuti wodwala amayang'aniridwa ndi katswiri wowachiritsa.
6. Erythromycin, komanso Clarothromycin, zimawonjezera kuchuluka kwa yogwira mapiritsi a Atomax omwe ali m'madzi a m'magazi.
7. Kuphatikiza ndi mankhwala monga Azithromycin sikukhudza mphamvu ya atorvastatin mu plasma yamagazi.
8. Ndikotheka kuchita zochizira zovuta ndikugwiritsa ntchito Terfenadine, chifukwa Atomax sasintha malo ake.
9. Kugwiritsa ntchito nthawi yomweyo kwa Atomax ndi njira zingapo zolerera zamkamwa, zomwe zimakhala ndi ethinyl estradiol ndi norethindrone, zimapangitsa kuwonjezeka kwakukulu mu AUC kwa zinthu izi.
10. Palibe chiwonetsero cha zovuta zilizonse zosokoneza mukaphatikiza mapiritsi awa ndi mitundu yonse ya estrogens.
11. Sizikudziwika kuti Atomax amagwirizana bwanji ndi mankhwala osiyanasiyana a antihypertensive.
12. Palibe kuyanjana kwamankhwala pamankhwala awa ndi "Cimetidine", komanso "Warfarin."
13. Ngati ndi kotheka, mankhwalawa amaloledwa kuphatikizidwa ndi othandizira omwe ali ndi amplodipine.
14. Akaphatikizidwa ndi proteinase inhibitors iliyonse, pamakhala kuchuluka kowonekera kwambiri kwa atorvastatin yomwe imasonkhana m'madzi a m'magazi.