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Kuchokera pazotsatira za ntchito yofufuza yomwe yachitika ku Yunivesite ya Alabama ku Birmingham, zikutsatira kuti kugwiritsa ntchito Verapamil kumakhudzanso kuchepetsa kufalikira kwa glucose mwa anthu odwala matenda ashuga. Kupeza kolimbikitsa kumeneku kunapangidwa ku Comprehensive Diabetes Center ku University of Alabama ku Birmingham, ndipo zotsatira zake zinafotokozedwa mu magazini ya Januwale of Diabetes Research and Clinical Exercice (2016.01.021). Lero, likulu likuyesa koyamba kwa mtundu wawo wa Verapamil (mothandizidwa ndi JDRF).

Yulia Khodneva, MD, Ph.D., wofufuza komanso wophunzirira zaudindo ku Dipatimenti ya Zodzikongoletsa, omwe amagwirizana nawo ku Comprehensive Diabetes Center, adasanthula ubale womwe uli pakati pa calcium Channel blockers, Verapamil makamaka, komanso kusala m'magazi a shuga pakati pa akulu 5,000 anthu omwe adapezeka ndi matenda ashuga omwe adatenga nawo gawo mu kafukufuku wa REGARDS.

Dokotala wa Zamankhwala Julia Khodneva.

Odwala okwana 1484 omwe amatenga calcium njira blockers adatenga nawo gawo la odwala akuluakulu omwe ali ndi matenda osokoneza bongo, omwe 174 adatenga Verapamil.

Zomwe zapezedwa zikuwonetsa kuti odwala omwe amatenga calcium channel blockers anali, pafupifupi, 5 mg / dl (0,3 mmol / L) shuga wambiri wa seramu poyerekeza ndi omwe sanamwe mankhwalawa. Odwala omwe amagwiritsa ntchito Verapamil, shuga wa seramu amachepetsa pafupifupi 10 mg / dL (0,6 mmol / L), poyerekeza ndi odwala omwe amatenga ma calcium blockers ena.

Ziwerengero zimawonetsanso kusiyana kwakukulu m'magazi a magazi mwa odwala omwe amatenga verapamil kuphatikiza ndi mankhwala a insulin ndi mkamwa: mwa iwo omwe amatenga Verapamil, mankhwala osokoneza bongo ndi insulin, kuchuluka kwa glucose mu seramu ya magazi kutsika ndi 24 mg / dl (

1.3 mmol / L) mwa odwala matenda a shuga omwe adatenga verapamil ndi insulin yokha, kuchepa kwa shuga m'magazi kunalembedwa 37 mg / dl (2 mmol / L).

"Chifukwa chinali kafukufuku wamtunda chabe Pambuyo pake tiyenera kuchita mayesero azachipatala mwangozi Verapamil, sitikudziwa mtundu wamgwirizano wapakati pa kugwiritsidwa ntchito kwa Verapamil komanso kutsitsa glucose wamagazi mwa anthu omwe ali ndi matenda ashuga, koma tikuona kuti kumwa mankhwalawa kumathandizira kuchepetsa magazi ”- anatero Pulofesa Khodneva.

Zotsatira zake zimapezeka mumagulu a odwala omwe ali ndi matenda a shuga 1 kapena omwe ali ndi vuto lachiwiri la matenda ashuga omwe amatenga Verapamil pamodzi ndi ofufuza odabwitsa a insulin.

"Kutsika kwa shuga m'magazi a omwe ali mgululi poyerekeza ndi omwe sanatenge Verapamil anali 37 mg / dl (2 mmol / l) - izi ndizokwera kwambiri kuposa zina zonse mwa odwala matenda ashuga akuluakulu"- akupitiliza Pulofesa Khodneva. "Izi zidatifikitsa ku lingaliro lakuti Verapamil ndi yothandiza kwambiri kwa odwala omwe ali ndi matenda amtundu woyamba 1 komanso odwala matenda ashuga a 2, maselo a kapamba zomwe zawonongeka kwambiri. Mwachidziwikire, mankhwalawa amagwira ntchito molingana ndi omwe asokoneza ma beta. ”.

"Dr. Julia Khodneva adagwira ntchito yayikulu ndikufufuza zambiri ndikuwona kuti Verapamil amathandizira kwambiri kuchepetsa shuga m'magazi a shuga""- Anatero Dr. Anat Shalev, woyang'anira wa Associated Diabetes Center ku Yunivesite ya Alabama ku Birmingham, mtsogoleri wasayansi wakuchipatala ku Verapamil.

"Kusintha kumeneku m'magazi a glucose omwe adalembedwa mwa odwala omwe akutenga verapamil akuyerekeza ndi kuchepa kwa Hb_A1c pafupifupi 1% . Kuchokera pomwe titha kunena kuti Verapamil amachita chimodzimodzi monga momwe amavomerezera kale matenda ashuga. Kuphatikiza apo, kusiyana kwakukulu m'magazi a glucose mwa odwala omwe atenga insulin kumachitika mogwirizana ndi lingaliro lathu lalikulu lomwe Verapamil amathandizira kubwezeretsa kuchuluka kwa maselo a beta ” - akuwonjezera Dr. Shalev.

University of Alabama ku Birmingham yalengeza za kuyesa kwa zamankhwala ku Verapamil mu Novembala 2014, ndipo idayamba kukopa odwala ku phunziroli mu Januware 2015. Zotsatira zoyambirira, pamaziko omwe zingatheke kuwunika momwe zotsatira za Verapamil pa mtundu 1 wa matenda ashuga, zakonzedwera kuti zipezeke pafupifupi miyezi 18.

Pakati pa mayesowa, njira yoyeserera imayesedwa yomwe imasiyana ndi njira zomwe zilipo masiku ano zochizira matenda a shuga, omwe cholinga chake ndi kubwezeretsa maselo a pancreatic beta, omwe amagwiritsidwa ntchito popanga insulini kuti azikhala ndi shuga.

Zotsatira zaka zambiri zofufuza, asayansi aku yunivesite atsimikizira kuti kuchuluka kwa shuga m'magazi kumapangitsa kuti thupi la munthu lipange protein yambiri ya TXNIP, momwe imachulukira maselo a beta poyankha kakulidwe ka matenda osokoneza bongo, komabe, mbali yake mu biology ya cell inali isanadziwike m'mbuyomu palibe. Kuchuluka kwa mapuloteni a TXNIP m'maselo a pancreatic beta kumabweretsa kufa kwawo, kulepheretsa kupanga kwa insulin, ndipo potero amathandizira pakukula kwa matenda a shuga.

Asayansi aku University nawonso adapeza kuti Verapamil, yogwiritsidwa ntchito kwambiri pochotsa kuthamanga kwa magazi, kugunda kwamtima kosagwirizana, komanso migraines, amatha kuchepetsa kuchuluka kwa mapuloteni a TXNIP pochepetsa kuchuluka kwa calcium m'maselo a beta. Mu mbewa za matenda ashuga okhala ndi shuga wamagazi ochulukirapo 300 milligrams pa desilita iliyonse (16.6 mmol / L), chithandizo cha Verapamil chinayambitsa kutsika kwa calcium kwambiri kotero kuti shuga idasiya kuwonekera.

Pakadali pano, asayansi aku Scottish awona kuti AMPK imakhudzanso kayendedwe ka kupuma kugona.

Verapamil, Verapamil ndi antiarrhythmic, hypotensive ndi antianginal othandizira gulu la ochedwa calcium calcium blockers, voliyumu yodalira calcium yotseketsa mtundu wa L-mtundu. Zochita za verapamil ndikuletsa njira za calcium (mkati mwa membrane wa khungu) ndikutsitsa transmembrane calcium yomwe ilipo.

Mphamvu ya Verarramil ya Verapamil ndikuchepetsa ndikuchepetsa mphamvu ya mtima, kupondereza atrioventricular ndi sinoatrial conduction, ndikuchepetsa automatism ya minofu yamtima. Chifukwa cha machitidwe a Verapamil, pali kukulitsa kwamitsempha yama mtima ndi kuwonjezeka kwa magazi othamanga, kuchepa kwa kufunikira kwa okosijeni pamtima.

Pakuchita kwa ischemic mu myocardium, verapamil imathandizira kuchepetsa kusalinganika pakati pa kufunika ndi kuperekera kwa oksijeni kumtima mwakuwonjezera kuchuluka kwa magazi ndi kugwiritsa ntchito bwino komanso kugwiritsa ntchito mpweya wabwino woperekedwa.

Mankhwala Verapamil amalembedwa kwa hypertrophic cardiomyopathy, idiopathic hypertrophic subaortic stenosis, matenda oopsa, ochepa matenda oopsa, angina pectoris (kuphatikizapo angina pectoris, postinfarction angina, angina pectoris, mtima atrial fibrillation kupatula WPW syndrome).

Verapamil imapangidwa mumitundu ingapo:

mapiritsi (okhala ndi utoto wa film, wokutidwa ndi filimu, wotenga nthawi yayitali),
nyemba zonona
jakisoni yankho
Njira yothetsera kulowetsedwa (mtsempha wama mtsempha).

Verapamil imapangidwa pansi pa mayina otsatsa awa: Verpamil, Veracard, Verogalid, Isoptin, Lecoptin, Caveril, Falicard, Phenoptin, Vepamil, Verapamil, Calan, Cardilax, Dilacoran, Falicard, Finoptin, Ikacor, Iproveratril, Isoptin, Vasopil.

Matenda a shuga

Matenda a shuga, matenda ashuga (malinga ndi ICD-10 - E10-E14), matenda ashuga (kuchokera ku Greek 6, _3, ^ 5, ^ 6, ^ 2, `4, _1,` 2, - "pruse pokodza") - gulu la endocrine matenda a metabolic omwe amadziwika ndi kuchuluka kwamphamvu kwa shuga (shuga) m'magazi chifukwa cha kufalikira kwathunthu (shuga 1) kapena wachibale (shuga 2) kuperewera kwa insulin.

Matenda a shuga amaphatikizidwa ndi kuphwanya lamulo mitundu yonse kagayidwe: chakudya, mafuta, mapuloteni, mchere wamchere ndi mchere, ndipo zimatha kuyambitsa zotsatira zoyipa mokhudzana ndi matenda amtima, kulephera kwaimpso, kuwonongeka kwa mitsempha, kuwonongeka kwa retina, kukanika kwa erectile.

Zizindikiro zotchulidwa kwambiri za matenda a shuga ndi ludzu (DM 1 ndi DM 2), kununkhira kwa acetone kuchokera mkamwa ndi acetone mu mkodzo (DM 1), kuchepa thupi (DM 1, ndi DM 2 m'magawo apambuyo), komanso kukodza kwambiri, zilonda zam'mimba miyendo, kuchiritsa kwamabala.

Mabwenzi okhazikika a shuga amakhala ndi glucose wambiri mu mkodzo (shuga mkodzo, glucosuria, glycosuria), ma ketoni mumkodzo, acetone mu mkodzo, acetonuria, ketonuria), mapuloteni amtundu wambiri mu mkodzo (proteinuria, albuminuria) ndi hematuria (mizimu yamatsenga, hemoglobin, maselo ofiira am'madzi mu mkodzo). Kuphatikiza apo, pH ya mkodzo mu shuga imasinthidwa ku mbali ya acidic.

Mtundu woyamba wa matenda a shuga 1, matenda a shuga 1, odwala matenda a shuga, achinyamata (ICD-10 - E10) ndimatenda a autoimmune a endocrine mtheradi kusowa kwa insulin, chifukwa chakuti chitetezo cha mthupi, pazifukwa sizikumveka, chikuukira ndikuwononga maselo a pancreatic beta omwe amapanga insulin ya mahomoni. Matenda a shuga amtundu woyamba amathanso kukhudza munthu wazaka zilizonse, koma matendawa amakula mwa ana, achinyamata ndi achikulire osakwana zaka 30.

Dinani ndikugawana nkhaniyi ndi anzanu:

Mtundu 2 wa matenda a shuga a mellitus, mtundu wa 2 shuga mellitus (osadalira insulini) (ICD-10 - E11) ndi nthenda yopanda autoimmune yodziwika ndi wachibale kusowa kwa insulini (zotsatira zake zomwe ndi kuchuluka kwa shuga m'magazi, chifukwa chophwanya kuyanjana kwa insulin ndi maselo amisempha). Matenda a shuga a Type 2 nthawi zambiri amakhudza anthu azaka zopitilira 40. Zomwe zimayambitsa matendawa sizimamvekanso bwino, koma anthu omwe ali ndi kunenepa kwambiri ali pachiwopsezo.

Kuyesedwa kwa magazi uku kumagwiritsidwa ntchito pakuwunika koyambirira kwa matenda a shuga, komanso kuwunika momwe matendawa aliri: kusala magazi m'magazi (nthawi zambiri kuyezetsa kumachitika kunyumba, glucometer amagwiritsidwa ntchito pofufuza magazi) komanso kuyeserera magazi mayeso, kuphatikiza kuyesa kwa glucose kulolera kwa glucose), kuyesa kwa glycosylated hemoglobin (glycated hemoglobin, Hb_A1c) komanso kuyezetsa magazi kwapafupipafupi (kuchepa kwa chiwerengero cha leukocytes kumawonetsa kuchepa kwa chithokomiro).

Chiyeso cha glucose wamagazi ndi mmol / lita (kumayiko a azungu, glycemia nthawi zambiri imayezedwa mg / desilita).

Zolemba

Zolemba ndi kufotokozera kwa nkhani "Verapamil amachepetsa shuga m'magazi a shuga."

University of Alabama ku Birmingham, University of Alabama ku Birmingham, UAB ndi yunivesite ya boma (ya anthu), imodzi mwa masukulu atatu mu yunivesite ya Alabama. Mwanjira yake yamakono, yunivesiteyo idakhalapo kuyambira 1969 (mkati mwa zamaphunziro pamaziko omwe yunivesite idakhazikitsidwa, kuphunzitsa kwachitika kuyambira 1936).

18700 ophunzira omaliza maphunziro ndi omaliza maphunziro.

Yunivesiteyi imapereka maphunziro mu dongosolo la mapulogalamu ophunzirira 140 m'madipatimenti 12 ophunzira, pomwe akatswiri pazokhudza anthu, chikhalidwe, sayansi yamakhalidwe, bizinesi, engineering ndi mankhwala amaphunzitsidwa. Sukulu ya zamankhwala ndiyolimba kwambiri pankhani zamano, mano, unamwino komanso thanzi la anthu.

Kafukufuku wa Matenda a shuga ndi Ntchito Zamankhwala - The Journal of the International Diabetes Federation (IDF) imasindikizidwa akatswiri odziwa zamankhwala komanso akatswiri othandiza pa zamankhwala, kufalitsa zolemba zapamwamba zasayansi zaposachedwa komanso kuwunika kwa akatswiri pankhani zokhudzana ndi matenda ashuga komanso minda ina. Magaziniyi imasindikizidwa ndi gulu la Elsevier.

Phunziro la zamankhwala (mayesero), mayesero azachipatala - kafukufuku wasayansi wochitidwa ndi kutenga nawo gawo kwa anthu kuti athe kuyesa chitetezo ndi kugwiritsa ntchito mankhwala atsopano, kukulitsa zomwe zikuwonetsa kugwiritsa ntchito chida chodziwika bwino cha mankhwala kapena chida chothandizira.

Mayesero azachipatala ndi gawo lofunikira pakupanga mankhwala osokoneza bongo kapena zida zochizira, asanalembetsedwe kwawo komanso chiyambi chogwiritsidwa ntchito kwachipatala chofala.

JdrfJuvenile Diabetes Research Foundation ndi zachifundo zokhazikitsidwa mu 1970 zomwe zimathandizira maphunziro a matenda ashuga a mtundu woyamba. Likulu la gululi lili ku New York, nthambi zake zimapezeka m'ma US ambiri, komanso kumayiko ena (ku Australia, Canada, Denmark, Israel, Netherlands ndi UK).

Dokotala wa Mafilosofi, PhD, Ph.D. Philosophiæ, Dokotala , ku University of Oxford - Doctor of Philosophy, D.Phil. - M'mayiko akunja iyi ndi digiri yomwe imaperekedwa kwa wofunsayo atakonzekera ndi kuteteza ntchito yoyenerera - dissertation ya udokotala. Dzinalo lomwe la digiriyo limakhala ndi ubale wosagwirizana ndi malingaliro, m'malo mwake limapereka ulemu pachikhalidwe.

Mu maphunziro aku Russia, digiri ya Doctor of Philosophy imafanana molondola ndi digiri ya Doctor of Philosophy.

Ku USA, digiri ya Doctor of Science yomwe ilipo ku mayunivesite pawokha (Sc.D. - Doctor of Science) imawerengedwa kuti ndi yolingana ndi Ph.D.

Maphunziro a postdoctoral, maphunziro a postdoctoral, postdocs - ku Western Europe, North America ndi Australia, kafukufuku wasayansi wochitidwa ndi wasayansi yemwe wangolandira kumene Ph.D. Chifukwa chake, wasayansi yemwe adachita nawo kafukufukuyu amatchedwa wophunzira wasukulu.

Calcium calcium blockers, block slowly calcium block blockers, BMKK, calcium antagonists - gulu lopambana la mankhwala opangidwa mwanjira ya mapiritsi, dragees, intravenous solution ndi jakisoni wa jekeseni yemwe ali ndi magwiritsidwe ofanana, koma amasiyana pamalo angapo, kuphatikiza ma pharmacokinetics, zotsatira kugunda kwa mtima, kusintha kwa minofu.

Njira yayikulu yogwiritsira ntchito calcium calcium blockers ndikulepheretsa kulowa kwa calcium ion kuchokera kumalo ophatikizika kumaselo a minyewa ya mtima ndi mitsempha yamagazi kudzera munjira zapang'onopang'ono za L-calcium. Calcium calcium blockers, kuchepetsa ndende ya Ca 2+ mu mtima ndi maselo osalala a minyewa, kukulitsa mitsempha ya mitsempha ndi zotumphukira m'mitsempha ndi ma arterioles, ndikukhala ndi tanthauzo la vasodilating.

Woimira woyamba wofunikira kwambiri wa calcium channel blockers, verapamil, adapezeka mu 1961 chifukwa cha kuyesa kupanga mapangidwe ena ofunikira kwambiri a papaverine, omwe ali ndi chotupa. Mu 1966, wolimbana ndi calcium wachiwiri, nifedipine, adapangidwa, ndipo mu 1971, diltiazem. Verapamil, nifedipine ndi diltiazem lero ndi oimira ophunzirira kwambiri a calcium Channel blockers.

MALANGIZO (The Reways for Geographic And Racial Difference in Stroke), pulojekiti yothandizidwa ndi National Institutes of Health (NIH), ndi kafukufuku wapadziko lonse yemwe amafuna kudziwa zambiri pazomwe zimawonjezera chiopsezo chokhala ndi matenda amtima.

Insulin, insulini ndi mapuloteni okhala ndi chilengedwe cha peptide, omwe amapangidwa m'maselo a beta a pancreatic a Langerhans. Insulin imakhudzanso kagayidwe kazinthu pafupifupi kakang'ono kamodzi, pomwe ntchito yake yayikulu ndikuchepetsa (kupititsa shuga) m'magazi.

Insulin imakulanso kupezekanso kwa michere ya plasma ya glucose, imayendetsa michere yofunika ya glycolysis, imalimbikitsa mapangidwe a glycogen mu chiwindi ndi minofu kuchokera ku glucose, ndikuwonjezera kaphatikizidwe ka mapuloteni ndi mafuta.Kuphatikiza apo, insulin imalepheretsa ntchito za ma enzyme omwe amawononga mafuta ndi glycogen.

Phunziro la pamtanda, kusanthula kwapachigawo, kusanthula pamalingaliro - amodzi mwa mitundu ya kafukufuku wowonetsa, wophatikizira kusanthula kwa deta yomwe idasonkhanitsidwa kamodzi, nthawi inayake.

Yesero lolamulidwa mwachisawawa ngakhale kafukufuku, RCT, kuyesedwa kosasankhidwa mosasankhika, kuyeserera kosasankhidwa, RCT - mtundu wa kuyesa kwasayansi, kawirikawiri kuyezetsa kwachipatala, momwe ochita nawo amagawika m'magulu awiri, zithunzi zosasinthika. Mu gulu loyamba, kulowererapo kwa kafukufuku kumachitika, yachiwiri, kuwongolera, njira zovomerezeka kapena placebo zimagwiritsidwa ntchito.

Maselo a pancreatic, islets of Langerhans - zochuluka za maselo opanga mahomoni (endocrine), makamaka mchira wa kapamba.

Pali mitundu isanu ya maselo a kapamba:

Glucagon wobisa maselo a alpha (wotsutsana ndi insulin)
Maselo a Beta obweretsa insulin (pogwiritsa ntchito mapuloteni olandilira omwe amayendetsa glucose m'maselo a thupi, amachititsa kuphatikizika kwa glycogen mu chiwindi ndi minofu, kuletsa gluconeogeneis),
Somatostatin-secretingting delta cell (kuletsa chinsinsi cha tiziwalo tambiri),
Maselo a PP obweretsa pancreatic polypeptide (kupondera kubisika kwa kapamba ndikulimbikitsa katulutsidwe ka madzi am'mimba),
Maselo a Epsilon obisalira ghrelin (yolimbikitsa chidwi).

Mu nkhani "Verapamil imatsitsa shuga m'magazi a shuga", maselo a kapamba amadziwika kuti ndiwo ma beta cell. Glycated hemoglobin, glycosylated hemoglobin, glycogemoglobin, hemoglobin A1c, Hb_A1c - chizindikiro cha magazi, chosonyeza kuchuluka kwa shuga m'magazi nthawi yayitali (mpaka miyezi itatu).

1% Hb_A1c_, zomwe Dr. Anat Shalev amalankhula zimafanana ndi zomwe zilimo

1.3-1.4 mmol / lita. Ngakhale chiwonetsero ichi chikusowa, kuchepa kwa Hb_A1c 1% yokha imawonetsa kuti: kuthekera kwa kuduladula kapena kufa chifukwa cha zotumphukira zamitsempha kumachepa ndi 43%, mwayi wazovuta zamatumbo unachepa (zomwe zingayambitse opaleshoni - kufinya kwamkati), ndipo mwayi wokhala ndi matenda amtima utachepa ndi 16%. kusakwanira. Mapuloteni a Thuoredoxin Othandizira, TXNIP, mapuloteni olumikizana ndi thioredoxin - mapuloteni otsekedwa ndi jini la TXNIP m'thupi la munthu. TXNIP ndi membala wa banja la mapuloteni a alpha-bindin (wokhudzidwa ndi kayendedwe ka kusintha kwa chizindikiridwe mu HCVF (G-protein coupept receptors).

TXNIP imalepheretsa ntchito ya antioxidant ya thioredoxin, zomwe zimapangitsa kuti mitundu yambiri ya okosijeni ithetsedwe komanso kupsinjika kwa ma cell. TXNIP imagwiranso ntchito ngati yowongolera ma cellular metabolism ndi "nkhawa" ya endoplasmic reticulum, ndipo imatha kuchita ngati chotupa choponderezera.

TXNIP imagwirizana kwambiri ndi hyperglycemia (hyperglycemia imathandizira kupsinjika kwa oxidative poletsa ntchito za thioredoxin reductase (enzyme yokhayo yomwe imachepetsa thioredoxin).

Kuti antianginal Mankhwalawa amaphatikizira othandizira angina pectoris.

Wolf-Parkinson-White Syndrome.

Wolff-Parkinson-White syndrome nthawi zambiri amadziwonetsa motsutsana ndi maziko a matenda amtima - mitral valve prolfall, hypertrophic cardiomyopathy, Ebstein anomaly. Kulephera kwamkati (malinga ndi ICD-10 - N17-N19) - vuto la impso losokoneza, lomwe limayambitsa kusokonezeka kwa nayitrogeni, elekitirodi, madzi, ndi mitundu ina ya kagayidwe, komwe kumachitika, kuphatikizapo oliguria, polyuria, proteinuria (protein yonse mu mkodzo) , glucosuria (ketonuria akhoza kulowa nawo shuga), kusintha kwamkodzo acidity, uremia, hematuria, kuchepa magazi, kukomoka, matenda oopsa.

Kulephera kwa impso (pachimake aimpso kulephera, malinga ndi ICD-10 - N17) - kuwonongeka kwadzidzidzi kwa impso ndi kuchepa kwa kusefedwa ndi kubwezeretsanso.

Kulephera kwa impso (CRF, malinga ndi ICD-10 - N18) ndi mkhalidwe womwe, chifukwa cha matenda a impso omwe amapita patsogolo, kufa pang'onopang'ono kwa minofu ya impso. Choyambitsa chachikulu cha kulephera kwa impso ndi matenda ashuga

33% ya milandu) ndi kuthamanga kwa magazi (ochepa)

25% ya milandu). Nthawi zambiri, zomwe zimayambitsa matenda a impso ndi matenda a impso.

Njira yosavuta kwambiri komanso yotsika mtengo yothandizira kuzindikira kusintha kwa mkodzo ndi mapepala ozindikira pa pH ya mkodzo, ngakhale ndi matenda a shuga ndikofunikira kugwiritsa ntchito mapepala pa ma ketoni.

Kunenepa kwambiri - kuchuluka kwa mafuta, kuchuluka kwa thupi chifukwa cha minofu ya adipose chifukwa cha kudya kwambiri komanso / kapena kuchepa mphamvu kwa mafuta. Masiku ano, kunenepa kwambiri kumawonedwa ngati matenda osachiritsika a metabolic (malinga ndi ICD-10 - E66), akukula msinkhu uliwonse, wowonetsedwa ndi kuchuluka kwambiri kwa thupi, makamaka chifukwa chodzikundikira minofu ya adipose.

Kunenepa kwambiri kumayendera limodzi ndi kuwonjezereka kwa vuto lodana ndi kufooka kwathunthu. Masiku ano, kwadziwika kuti kunenepa kwambiri ndi chimodzi mwazomwe zimayambitsa kukula kwa matenda ashuga amtundu wa 2.

Polemba nkhani kuti asayansi aku America akhazikitsa mgwirizano pakati pa kutenga Verapamil ndikuchepetsa kuchuluka kwa glucose m'magazi omwe ali ndi matenda a shuga, zinthu zomwe zimagwiritsidwa ntchito zinali zidziwitso ndi zolemba pa intaneti, malo a News DiabetesResearchClinicalPractice.com, Mankhwala Osokoneza bongo. com, NIH.giv, JDRF.org, GeneCards.org, ScienceDaily.com, Med.SPbU.ru, VolgMed.ru, Wikipedia, komanso zofalitsa zotsatirazi:

Leia Yu. Ya. "Kuunikira pazotsatira zamayesero am magazi ndi mkodzo." Kusindikiza nyumba MEDpress-kudziwitsa, 2009, Moscow,
Henry M. Cronenberg, Shlomo Melmed, Kenneth S. Polonsky, P. Reed Larsen, "Matenda a shuga ndi matenda a carbohydrate metabolism". Nyumba yosindikiza "GEOTAR-Media", 2010, Moscow,
A. John Kam, Thomas F. Lusher, Patrick W. Serruis (akonzi) “Matenda a mtima ndi mitsempha yamagazi. Malangizo a European Society of Cardiology. " Nyumba yosindikiza "GEOTAR-Media", 2011, Moscow,
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Nkhani yoyambirira "Anthu odwala matenda ashuga omwe amagwiritsa ntchito verapamil ali ndi shuga ochepa, chiwonetsero cha data". Yotanthauzidwa ndi Julia Korn, kusintha – ogwira ntchito yolemba.