Malangizo a Humulin m3

Kufotokozera kogwirizana ndi 29.04.2015

• Dzina lachi Latin: Humulin M3
• Code ya ATX: A10ad
• Chithandizo: Magawo awiri a insulin opanga ma insulin (Insulin biphasic human biosynthet)
• Wopanga: Eli Lilly East S.A. (Switzerland)

1 ml ya kuyimitsidwa kumaphatikizapo 100 IU mobwerezabwereza insulin ya anthu (30% insulin yosungunuka ndi 70% insulin isophan- - yogwira pophika.

Zosakaniza Zocheperako: phenol, glycerol, protamine sulfate, sodium hydrogen phosphate heptahydrate, hydrochloric acid, zinc oxide, madzi d / ndi, sodium hydroxide.

Pharmacodynamics ndi pharmacokinetics

DNA yobwereza Kukonzekera kwa insulin ya Humulin M3 ndi kuyimitsidwa pang'ono kwa jekeseni kawiri komwe kumakhala nthawi yayitali yochita. Pambuyo jekeseni, pharmacological lapamwamba insulinimawonekera pambuyo pa mphindi 30-60 ndipo imafika patadutsa maola 2 mpaka 12, nthawi yayitali maola 18-24.

Ntchito insulinakhoza kukhala ndi kusiyana komwe kumadalira madera oyendetsa mankhwala, mlingo woyenera, zochitika zolimbitsa thupi za wodwalayo Zakudya ndi zina.

Zotsatira zazikulu za Humulin M3 zimayendetsedwa ku kayendetsedwe ka njira shuga kagayidwe, motsatana, mankhwalawa amawonekera ndipo anabolic zotsatira. M'matumbo amisempha ndi minyewa ina (kupatula minofu yaubongo), insulinzimakhudza kutsegula kwa intracellular mayendedwe amino acid ndi shugaimathandizira mapuloteni anabolism.

Humulin insulin M3 imakonda kusintha kwa chiwindi shugamu glycogenamathandiza kutembenuka kwa zochuluka shugamu mafutandi zoletsa gluconeogenesis.

Zotsatira zoyipa

Pochita mankhwala insulin, kuphatikiza Humulin M3, nthawi zambiri mutha kuwona chitukuko hypoglycemiaomwe mu mawonekedwe owopsa angayambitse hypoglycemic chikomokere (kuponderezanandi kulephera kudziwa), ndipo nthawi zina, kuti zakupha.

Odwala amatha thupi lawo siligwirizana mderalo mawonekedwe kuyabwa, kudzikuzakapena rednessm'malo jakisoni, nthawi zambiri amadutsa patatha masiku angapo kapena milungu. Nthawi zina izi sizimagwirizana ndi kugwiritsa ntchito insulin, koma ndi chifukwa cha zinthu zakunja kapena kuyendetsa bwino mankhwala.

Komanso, kuwonetseredwa thupi lawo siligwirizanazomwe zimachitika kawirikawiri, koma zoyipa kwambiri. Kuwonetsedwa kwa zoterezi zitha kutsatiridwa kuvutika kupumaophatikizidwa kuyaka, kupuma movutikirakugunda kwa mtima kutsitsa magazikuchuluka thukuta.

Muzochitika zazikulu kwambiri, izi sizingasokoneze moyo wa wodwalayo ndipo zimafunikira chithandizo chamwadzidzidzi. Pangafunika kugwiridwa kukakamirakapena m'malo mwake insulin.

Kukaniza, lipodystrophy ndi Hypersensitivitykuti insulinnthawi zambiri zimachitika mukamagwiritsa ntchito nyama insulin. Kuthekera kwakutukuka kwawo pogwiritsa ntchito insulin Humulin M3 kuli pafupi ndi zero.

Malangizo ogwiritsira ntchito (Njira ndi Mlingo)

Mu / pakubweretsa Humulin M3 ndi koletsedwa.

Pankhani ya insulin, Mlingo wawo ndi makonzedwe a makonzedwe amasankhidwa ndi dokotala ndipo yekhayo, malinga ndi msinkhu glycemia. Humulin M3 imagwiritsidwa ntchito poyang'anira subcutaneous, ngakhale kuti kubayidwa kwa IM nthawi zina kumaloledwa.

Subcutaneous makonzedwe amachitika m'mimba, ntchafu, phewa kapena matako. Amayesa kugwiritsa ntchito malo amodzi jakisoni nthawi imodzi m'masiku 30, ndiye kuti amasinthana kamodzi pamwezi. Mukamagwira jakisoni, muyenera kugwiritsa ntchito zida za jakisoni moyenera, kupewa kulowetsamo singano m'matumbo, ndipo musamuwiritse ntchito jakisoni wothandizirayo pambuyo pakukonzekera.

Humulin M3 ndi osakaniza opangidwa kale, osakanizidwa kale Humulin NPH ndi Humulin Wokhazikika, zomwe zimapewa kukonzekera yankho ndi odwala omwe.

Kukonzekera mlingo insulinMbale kapena ma cartridge a Humulin M3 azikulungika m'timabowo ma jakisoni maulendo 10 m'manja ndi manja pang'ono ndikugwedezeka pang'ono ndi pang'ono, kutembenuka ndi 180 ° mpaka kuyimitsidwa kumawoneka ngati madzi osalala kapena ngati mkaka.

Gwedezani mwamphamvu insulinsiziyenera kutero, chifukwa izi zimatha kuyambitsa mawonekedwe a thovu, omwe amasokoneza kuchuluka kwa Mlingo.

Komanso siziyenera kugwiritsidwa ntchito. insulinndi masamba kapena matope otsalira mukasakaniza.

Makulidwe a insulin

Zoyenera kumwa mankhwala insulinnjira zina zoyambirira ndizofunikira. Kuti muchite izi, muyenera kusankha malo a jekeseni ndikupukuta ndi manja omwe adasambitsidwa kale ndi nsalu. Ndiye chotsani kapu yakunja yoteteza ku singano ya syringe ndikukonza khungu, mwa kufinya kapena kukoka, ikani singano ndikupanga jakisoni. Chotsani singano ndipo kwa masekondi angapo sinikizani malo a jakisoni ndi minofu osafunsira.

Zitatha izi, pogwiritsa ntchito singano yakunja yoteteza, mukufunika kuchotsa singano, kuichotsa ndikuyibwezeranso ndi cholembera.

Zingwe za syringe cholembera sizigwiritsidwa ntchito kawiri. Mbale ndi ma cartridge agwiritsidwa ntchito mpaka atapanda kanthu, ndikuchotsedwa. Ma cholembera a syringe ndi ogwiritsa ntchito pawokha.

Bongo

Insulin Humulin M3, monga nthumwi zina za mankhwalawa, sizikhala ndi tanthauzo la bongo, chifukwa seramu kuchuluka kwa shuga ndi chotsatira cha kulumikizana kwadongosolo pakati pazokhazikika shuga, insulinndi njira zina kagayidwe.

Hypoglycemiaamakula chifukwa chosavomerezeka pazinthu za m'madzi a m'magazi insulinmokhudzana ndi mtengo wamagetsi ndi zakudya zomwe zimatengedwa.

Zizindikiro za Kutuluka hypoglycemiazitha kuchitika: ulesikusanza tachycardiakuchuluka thukutakhungu, kunjenjemera, mutu, chisokonezo. Nthawi zina, monga nthawi yayitali matenda ashugakapena kuwongolera kwambiri, zizindikiro zam'mbuyomu hypoglycemiazingasiyane.

Hypoglycemia mawonekedwe ofatsa atha kupewedwa kudzera mkati shugakapena shuga. Mungafunike kusintha pazenera. insulinkukonzanso Zakudyandi / kapena kusintha zolimbitsa thupi.

Chithandizo hypoglycemiazolimbitsa zolimbitsa thupi nthawi zambiri zimachitika ndi sc kapena intramuscularly glucagon, ndikulandilanso kwamkati chakudya.

Pankhani yoopsa hypoglycemiandi zovuta zamitsempha, spasmskapena chikomokereSC kapena IM yawonetsedwa glucagonkapena jakisoni shuga kuganizira.

Pambuyo pake, kupewa kupangidwanso hypoglycemia, wodwalayo akulimbikitsidwa kudya zakudya zabwino chakudya. Mikhalidwe yayikulu kwambiri ya hypoglycemic imafunika kuchipatala mwachangu.

Kuchita

Hypoglycemic mankhwala (mkamwa), Mowasalicylates Mao zoletsa, sulfonamidesACE zoletsa (Enalapril, Captopril), angiotensin II receptor blockers, opanga beta (posasankha) zimathandizira kukonza kwa Humulin M3.

Glucocorticoids, kulera kwamlomokukula kwa mahomoni ndi chithokomiro Danazole, thiazide okodzetsabeta2-sympathomimetics (Salbutamol, Ritodrin, Terbutaline) zotsika za hypoglycemic insulin.

Lancreotide, Octreotide ndi ma fanizo ena somatostatinkuchulukitsa kapena kuchepa kudalira kwa insulin.

Malangizo apadera

Kudzisokoneza podzichiritsa kapena kugwiritsa ntchito mankhwala osakwanira, makamaka wodwala insulinodwala, angayambitse mapangidwe a matenda ashuga ketoacidosiskapena hyperglycemiaomwe akhoza kukhala pangozi.

Odwala ena, akagwiritsidwa ntchito insulin yamunthuzizindikiro zam'mbuyomu hypoglycemiaikhoza kukhala yosiyana ndi zizindikiro zofananira zikagwiritsidwa ntchito nyama insulin kapena kuwonetsa mu mawonekedwe ofowoka.

Wodwala akuyenera kuchenjezedwa kuti ndi zomwe zili momwe ziliri shugam'mwazi, makamaka chifukwa champhamvu mankhwala a insulinzizindikiro zam'mbuyomu hypoglycemiazitha kuzimiririka. Komanso, chizindikiro ichi sichitha kuzindikira pang'ono kapena kusintha ngati chikugwiritsidwa ntchito. opanga beta, matenda ashuga a m'mimba kapena matenda ashugaanati kwa nthawi yayitali.

Malo osagwirizana hyperglycemia kapena hypoglycemiazingayambitse kulephera kudziwachikomokere ndi ngakhale patsogolo zakupha.

Kusamutsa wodwalayo kwa ena insulinmankhwala kapena mitundu yawo iyenera kuchitika mosamalitsa woyang'aniridwa ndi achipatala. Kusintha kupita ku insulinndi ntchito zina (NPH, Nthawi zonseetc.), njira yopanga (chinyama, DNA yobwereza), kuyanjana kwamtundu (analog, nkhumba) ingafune kusintha mosachedwa kapena pang'ono pang'onopang'ono kwa Mlingo womwe waperekedwa.

At matenda a chiwindi ndi impsokuchepa kwa ntchito zodabwisa, gren adrenal kapenachithokomiro wodwala angafunike zochepa insulin, ndipo liti kupsinjika mtima ndi zina zina zofananira, ziwonjezeka.

Kusintha kwa Mlingo wa insulin kungafunike ngati kusintha kumachitika. zakudya mankhwalakapena kuchuluka zolimbitsa thupi.

Pokhudzana ndi kuthekera kwa chitukuko hypoglycemia, wodwalayo ayenera kuwunika moyenera mkhalidwe wake ngati kuli kotheka kuchita ntchito yowopsa kapena kuyendetsa galimoto.

• Monodar (K15, K30, K50),
• Ryzodeg Flextach,
• Novomix 30 Flexspen,
• Kusakaniza Kwa Humalog (25, 50).

• Vosulin 30/70,
• Gensulin M (10, 20, 30, 40, 50),
• Vosulin N,
• Gensulin N,
• Mikstard 30 nm,
• Rinsulin NPH,
• Protafan NM,
• Farmasulin N 30/70,
• Humulin,
• Humodar Betc.

Mimba (ndi mkaka wa m'mawere)

At wa mimbaazimayi akuvutika matenda ashugaulamuliro glycemiazofunika kwambiri. Nthawi imeneyi, monga lamulo, kufunika kwa insulinAmasinthasintha (amachepetsa m'nthawi yoyamba ndikuwonjezereka kwa II ndi III), komwe kungafune kusintha kwa mlingo.

Komanso, kusintha kwa muyezo, ngati zakudya mankhwalandi zolimbitsa thupi ingafunike pamene yoyamwitsa.

Ndemanga za odwala matenda ashuga za Humulin M3, ngati izi insulinyoyenera kwathunthu kwa wodwala, ali ndi malingaliro. Malinga ndi iwo, mankhwalawa ndi othandiza kwambiri ndipo sikuti amayambitsa mavuto.

Ndikofunika kukumbukira kuti mumadzisankhira nokha insulin, komanso kuzisintha kukhala zina, ndizoletsedwa kwathunthu, izi ziyenera kuchitidwa ndi dokotala woyenerera, atatenga mbiri ndikuwunika wodwalayo kwathunthu.

Humulin - phindu la insulin ndi chiyani?

Kwa zaka zambiri osalimbana ndi ma DIABETES?

Mutu wa Bungwe: “Mudzadabwitsidwa kuti kumakhala kovuta motani kuchiritsa matenda a shuga tsiku lililonse.

Humulin insulin ndi chinthu chochepa. Chofunika kwambiri, chimaphatikizidwa mu gulu lomwe limatchedwa NPH insulin, ndiye kuti, omwe ali ndi mavitamini a Hadeghorn, mwachitsanzo, m'mbewu. Kulowa m'gululi amangoti, ngakhale zili ndi mphamvu, sizimalowerera ndale ndipo zimatha kuchita ntchito wamba. Za izi komanso mtsogolo mwake munkhaniyi.

Pa kapangidwe ndi mawonekedwe amasulidwe

Insulin ndi njira yopanda utoto momveka bwino, monga momwe alili Sladis, yemwe amapangidwa mwanjira yapadera. Muyenera kusiyanitsa mitundu iwiri ya mankhwala omwe ali ndi dzina la "Humulin":

• poyambirira, gawo lalikulu ndi insulin yosungunuka, yomwe idapangidwa ndi njira yofufuza zamtundu - wokhazikika,
• lachiwiri - insulin yaumunthu - NPH.

Chifukwa chake, olandira, kuphatikiza ndi fructose, ayenera kugawidwa. Mu mitundu yoyamba, ndi metacresol, glycerol, madzi oyeretsedwa, komanso zinthu zina. Wachiwiri uli ndi metacresol, glycerin, hydrochloric acid mtundu. Chifukwa cha kapangidwe kameneka, osati koyambirira kokha, komanso kachiwiri, zimatha kukhalabe ndizowonetsa osati zokhazo za NPH pamlingo woyenera, komanso ntchito zonse zogwirizana ndi zokhazikika. Izi zimapangitsa Humulin insulin kukhala imodzi yofunidwa kwambiri, monga Huxol.

Zokhudza zotsatira zamankhwala

Pofotokoza za kufalikira kwa zamankhwala, ziyenera kudziwika kuti mtundu wa insulin ndi mitundu yosiyanasiyana ya DNA. Monga tanena kale, iyi ndi insulin yochepa.

Mphamvu yayikulu ya mankhwalawa iyenera kuganiziridwa potsatira malamulo a shuga - zomwe zimagwiranso ntchito ku Milford. Kuphatikiza apo, imadziwika ndi zotsatira za anabolic. Mu minofu ndi minyewa ina yonse (kupatula ubongo), Humulin amasinthanitsa kukhudzana kwamkati pakati pa shuga ndi ma amino acid osiyanasiyana. Imathandizanso kwambiri kuyanjana kwa mapuloteni.

Insulin imathandizira kutembenuka kwa glucose kukhala glycogen m'chiwindi, imabwezeretsa njira zonse za gluconeogenesis, kuphatikiza apo, ndikofunikira kuti kusandulika kwa glucose owonjezera kukhala zinthu zamafuta.

Zonsezi zimakhudza bwino mulingo wa NPH, womwe, umakhala wofunikira nthawi zonse.

Kukhazikika kwa kuwonekera kwa mankhwalawa kumachitika patatha mphindi 30 kuchokera ku kukhazikitsidwa kwake, ndipo mphamvu yayitali kwambiri yomwe imachitika pakati paola loyamba ndi lachitatu, nthawi ya zotulukazi imayamba kuchokera maola asanu mpaka asanu ndi awiri.

Kusiyana kwamwini pa kuchuluka kwa zochita za insulin kumadalira mwachindunji pazinthu monga:

1. Mlingo
2. kusankha jekeseni dera
3. kuchuluka kwa zolimbitsa thupi odwala matenda ashuga.

Zonsezi ndiumboni mwachindunji kuti kusinthasintha kwa PNH ndizowonjezereka, komwe kumakhudza chizindikirocho pafupipafupi.

About mlingo ndi makonzedwe

Mlingo watsimikiza ndi katswiri aliyense payekha, amatero malinga ndi mkhalidwe wa glycemia. Humulin ikhoza kutumikiridwa m'njira zingapo: pansi pa khungu, mtsempha wa magazi, jakisoni wamkati ulinso kutheka.

Pansi pa khungu, insulin imalowetsedwa phewa, ntchafu, matako kapena m'mimba. Malo a jakisoni asinthidwe kuti malo omwewo asagwiritsidwenso ntchito kawirikawiri, makamaka kamodzi pamwezi.

Ndi kulowetsedwa kwa subcutaneous, ndikofunikira kwambiri kusamala mwapadera kuti musalowe m'gawo lamitsempha yamagazi. Pambuyo pa jekeseni, sibwino kupaka mphamvu dera loyang'anira. Anthu odwala matenda ashuga ayenera kulangizidwa pakugwiritsa ntchito bwino zida zoyambitsa matenda a insulin. Izi zipangitsa kuti zitheke kuthana ndi kudziimira pawokha popanda matenda a NPH ndikukhala okhazikika nthawi zonse.

Ndikofunikanso kukumbukira zina mwanjira zovomerezeka zogwiritsira ntchito Humulin; zimachitika chifukwa chakuti insulin iyi ikhoza kugwiritsidwa ntchito pokhapokha ngati ili ndi madzi osavuta popanda mthunzi. Palibe chifukwa chogwiritsira ntchito mankhwalawa ngati muli ndi ma flakes osiyanasiyana, komanso ngati mawonekedwe oyera oyera atatsamira pansi kapena makhoma achidebe.Komabe, amatha kubwereza zomwe zimachitika mu njira za chisanu. Kupanda kutero, kugwiritsidwa ntchito kwake kungakhale koopsa.

Tiyeneranso kukumbukira kuti:

• makatoni ogwiritsira ntchito komanso mabotolo ayenera kufufuzidwa mosamala kwambiri,
• Kukhazikitsa ma cartridge omwewo kumapangitsa kuti zisakhale zosakanikirana ndi zomwe zimapezeka ndi mitundu ina ya insulini mu katiriji palokha. Zida izi sizingagwiritsidwe ntchito pakudzaza kwachiwiri komanso zambiri.

Ndi mtsogolo kuti izi zimatha kusamalira kuchuluka kwa NPH ndi zizindikiro zonse zomwe zimagwirizanitsidwa ndi zokhazikika.

Kuchotsa singano mutabaya jekeseni kudzakhala chitsimikizo cha kusabala, kuthandizira kupewa kutayikira, komanso mpweya wambiri komanso zotsekera zotheka. Kuphatikiza apo, singano singagwiritsenso ntchito kangapo.

Zotsatira zoyipa

Choyipa chachikulu chomwe chimalumikizidwa ndi zotsatira zazikulu za mankhwalawa ndi hypoglycemia. Mitundu yowopsa ya nthendayi yopatsidwayo imatha kupangitsa kuti musamachedwe kuzindikira kapena kufa kwakanthawi komanso (mwapadera) imfa.

Thupi lawo siligwirizana.

Izi zikuphatikiza mawonetseredwe am'deralo, mwachitsanzo, hyperemia, kutupa kapena kuyabwa m'malo a jekeseni, omwe nthawi zambiri amasiya pakatha masiku angapo mpaka masabata.

Zomwe zimadziwika kuti zimachitika mwachilengedwe zimatha. Amakhala ocheperako pafupipafupi, koma zimakhala zowopsa kwambiri. Tikuyankhula za kuyabwa kwakukulu, kupuma movutikira, kupuma movutikira, kutsitsa magazi, kuthamanga kwa mtima komanso kutulutsa thukuta kwambiri. Kuti mupewe izi, NPH ndi zizindikiro zokhazikika ziyenera kuyang'aniridwa.

Mawonekedwe ovuta makamaka azamachitidwe owopsa amatha kukhala owopsa m'machitidwe onse amoyo. Zotsatira zina zoyipa zitha kuphatikizanso kuthekera kwa lipodystrophy, yomwe, komabe, ndiyochepa.

Pazakusungidwa

Mankhwalawa amayenera kusungidwa mufiriji yapadera kutentha kwa madigiri awiri mpaka asanu ndi atatu. Mkhalidwe wina wofunikira ndikupewa kuzizira, kufunikira koziteteza ku mphamvu yosangotulutsa dzuwa, komanso kuwala. Moyo wa alumali ndendende zaka ziwiri kuyambira tsiku lopanga.

Insulin yomwe ili mu cartridge kapena botolo, koma ikugwiritsidwa ntchito kale, iyenera kusungidwa kutentha, ndiye kuti, kuchokera ku 15 mpaka 25 digiri yopitilira masiku 28. Izi zikutsimikizira mulingo woyenera wa NPH komanso wokhazikika, ndizofunikira kwambiri kwa onse odwala matenda ashuga.

Zokhudza contraindication

Tiyeneranso kudziwa kuti ma contraindication, omwe amadziwika ndi "Humulin". Izi zikuphatikiza mawonekedwe awa:

1. mtundu uliwonse wa hypoglycemia,
2. kuchuluka kwa chiwopsezo ndi chidwi cha thupi kuloza insulini kapena chilichonse chomwe chimapangitsa mankhwalawo.

Kutsatira zomwe zakwaniritsidwa ndikupanga kuti zikhale zotheka kukhala chimodzimodzi osati NPH, komanso wamba. Ichi chidzakhala chinsinsi cha thanzi labwino mu shuga, osati oyamba okha, komanso mtundu wachiwiri. Chifukwa chake, kugwiritsa ntchito "Humulin" molingana ndi malangizowa kuyenera kuganiziridwa kuti ndiyo njira yokhayo yoyenera yopewera matendawa.

Momwe mungagwiritsire ntchito Humulin?

Mlingo, dongosolo la makonzedwe ndi kuchuluka kwa majakisoni amatsimikiziridwa ndi adokotala, kutengera zosowa zenizeni komanso molingana ndi vuto lililonse.

Humulin imayendetsedwa ndi jekeseni wa subcutaneous, koma amathanso kutumikiridwa ndi jakisoni wa intramuscular, ngakhale njira iyi yoyendetsera siilimbikitsidwa. Humulin sayenera kutumikiridwa kudzera m'mitsempha. Jekeseni wofunda wam'mapewa amapatsidwa phewa, ntchafu, matako kapena pamimba. Mukamayambitsa insulin iliyonse pokonzekera ndi Humulin, kuyambitsidwa kwa singano m'mitsempha yamagazi kuyenera kupewedwa. Pambuyo pa mankhwala, mankhwalawa sayenera kuzikhuthula. Upangiri watsatanetsatane uyenera kuperekedwa ndi odwala zokhudzana ndi jakisoni.

Humulin ndi insulin yosakanikirana ndi Humulin (R) Yokhazikika ndi Humulin (R) NPH, yopangidwa mwapadera kuti wodwalayo asadzikonzekeretse insulin. Njira zochizira wodwala aliyense zimakhazikitsidwa malinga ndi zosowa zake kutengera kayendedwe ka kagayidwe.

Mavuto osakanikirana ndi insulin ya anthu ndi ma insulin a nyama kapena ndi ma insulin a anthu kuchokera kwa opanga ena sizinafufuzidwe.

Kukonzekera mlingo wa Humulin (R) M3 (30/70), Humulin NPH

Musanagwiritse ntchito insulin m'makatoni ndi Humulin (R) M3 (30/70), iyenera kuyambiranso kupomedwa ndi cartridge (vial) pakati pa manja maulendo 10 ndikusintha 180 ° 10 mpaka kuyimitsidwa kumakhala ngati turbid kapena milky. Ngati madzi mu cartridge sanapeze mawonekedwe oyenera, bwerezani ntchito mpaka zomwe zili mkati zisakanizidwa kwathunthu. Makatoni okhala ndi mkanda wamgalasi kuti uzithandizira kusakanikirana. Osagwedeza kwambiri cartridge, chifukwa izi zingayambitse kupangika kwa thovu, zomwe zingasokoneze muyeso wolondola wa mlingo.

Onani pafupipafupi mawonekedwe a katiriji ndipo musagwiritse ntchito ngati kuyimitsidwa kuli ndi ziphuphu kapena ngati tinthu tating'onoting'ono timamatira pansi kapena makhoma a cartridge, ndikupangitsa kuti galasi lisungidwe.

Makatoni sanapangidwe kuti aphatikize ma insulin osiyanasiyana.

Makatoni opanda kanthu sangathe kugwiritsidwanso ntchito.

Kuti muwongolele cartridge mu jakisoni, ikani singano ndi jakisoni, tsimikizirani malangizo a wopanga jakisoni wa insulin.

Gwiritsani ntchito syringe yomaliza maphunziro yomwe imagwirizanitsa ndi mlingo womwe umayenera kuperekedwa.

Kukonzekera kwa Humulin Mlingo wokhazikika

Mankhwala Humulin Wokhazikika m'mabotolo safuna kupumulanso, ayenera kugwiritsidwa ntchito pokhapokha yankho likakhala lomveka, lopanda utoto, lilibe tizinthu tooneka komanso ngati madzi.

Zosakanikirana za insulin: Choyamba muyenera kulembera insulin mwachangu mu syringe, kuti mupewe mankhwala osafunikira omwe atenga nthawi yayitali. Ndikulimbikitsidwa kupaka jekeseni mukasakaniza.

Pakukhazikitsa mtundu uliwonse wa mankhwalawa, mutha kugwiritsanso ntchito ma syringe osiyana a Humulin Regular komanso a Humulin NPH.
Konzani syringe musanalowe jakisoni ndi dokotala kapena namwino.
Gwiritsani ntchito syringe yomaliza maphunziro yomwe imagwirizanitsa ndi mlingo womwe umayenera kuperekedwa.

C) Kuchotsa makatoni ndi singano zogwiritsidwa ntchito.

Singano zizigwiritsidwa ntchito kamodzi. Tengani singano ndikuziyika pamalo otetezeka.

Pensulo ndi singano zizigwiritsidwa ntchito mosamalitsa.

Makatoni amagwiritsidwa ntchito mpaka opanda kanthu, pambuyo pake ayenera kuchotsedwa.

Kusintha kulikonse kwa mtundu kapena mtundu wa insulin kuyenera kuchitika moyang'aniridwa ndi achipatala. Mukamasintha ndende, mtundu (womwe ukufanana ndi wopanga winawake), lembani (mwachangu kuchitapo kanthu, NPH, pang'onopang'ono, etc.), lembani (insulin ya nyama, insulin yaumunthu, analog ya insulin ya anthu) ndi / kapena njira yokonzekera (insulin, yomwe opezeka pogwiritsa ntchito ukadaulo wama DNA obwerezabwereza, mosiyana ndi insulin yochokera ku nyama) kusintha kwakukulu kungafunike.

Mlingo pochiza odwala omwe ali ndi insulin ya anthu amatha kusiyana ndi Mlingo womwe umagwiritsidwa ntchito pochiza insulin yoyambira nyama. Ngati pakufunika kusintha kwa mlingo, mankhwalawa atha kuchitika kuchokera pa koyamba kapena mkati mwa milungu ingapo kapena miyezi ingapo.

Odwala ena omwe anali ndi vuto la hypoglycemic atatembenuka kuchoka ku dongosolo la mankhwala a insulin yoyambira nyama kupita kumalo amtundu wa insulin yoyendetsera anthu, zofunikira zakuchenjeza za hypoglycemia sizinatchulidwe kapena zosiyana ndi zomwe zimawonedwa kale mwa odwala awa akamalandira mankhwala a insulin. Odwala omwe ali ndi matenda a shuga m'magazi (mwachitsanzo, chifukwa cholimba cha mankhwala a insulin), ena mwa iwo kapena ena mwa zizindikiro zoyambitsa za hypoglycemia sangawonedwe mtsogolo, zomwe akuyenera kudziwitsidwa. Zizindikiro zoyambirira za hypoglycemia zimatha kukhala zosiyana kapena zochepa kutchulidwa kwa odwala omwe ali ndi matenda ashuga a nthawi yayitali ndi matenda a shuga, kapena odwala omwe amamwa mankhwala ena, monga beta blockers, mogwirizana ndi chithandizo chamankhwala. Kuperewera kwa kukonza kwa hypoglycemia kapena hyperglycemic zimatha kutha kukayika, chikomokere ndi kufa.

Kulephera kuchita kapena kusiya kulandira chithandizo (makamaka kwa odwala omwe ali ndi matenda osokoneza bongo omwe amadalira insulin) kungayambitse matenda a hyperglycemia komanso matenda oopsa a matenda ashuga a ketoacidosis.

Kuchiza ndi insulin yaumunthu kungayambitse kukula kwa ma antibodies, makamaka pazotsika kuposa poyerekeza ndi insulin yanyama.

Kufunika kwa insulini kumasintha kwambiri ndi kusokonekera kwa ntchito ya adrenal gland, pituitary gland, chithokomiro cha chithokomiro, impso kapena chiwindi.

Kufunika kwa insulini kungachulukenso panthawi yomwe mukudwala kapena mukulimbikitsidwa ndi nkhawa.

Kufunika kosinthira kwa mlingo kumatha kuchitika ngati pakuchitika masinthidwe azolimbitsa thupi kapena zakudya wamba.

Gwiritsani ntchito pa nthawi yoyembekezera komanso nthawi yotsira.

Kusunga shuga wokwanira m'magazi a amayi apakati omwe amathandizidwa ndi insulin (yokhala ndi mitundu yotsalira ya insulin komanso mitundu yokhudzana ndi matenda a shuga) ndikofunikira kwambiri. Kufunika kwa insulin nthawi zambiri kumachepetsa panthawi yoyamba kubereka, pambuyo pake kumawonjezeka panthawi yachiwiri komanso yachitatu.

Amayi omwe ali ndi matenda ashuga ayenera kuuza madokotala awo za mimba kapena cholinga chawo chokhala ndi pakati.

Kwa amayi omwe ali ndi matenda a shuga panthawi yoyamwitsa, pakhoza kufunikira kuwongolera Mlingo wa insulin komanso / kapena zakudya.

Kukopa luso lotha kuyendetsa galimoto ndi njira zina zamakina. Hypoglycemia imatha kusokoneza maganizidwe ndi kusokonezeka kwa zinthu, i.e. imakhala pachiwopsezo pamavuto omwe amafunikira makhalidwe omwe atchulidwa, mwachitsanzo, poyendetsa galimoto kapena zida zamagetsi. Odwala ayenera kudziwitsidwa za njira ziti zomwe ziyenera kugwiritsidwa ntchito musanayendetse, pofuna kupewa kuchulukana kwa hypoglycemia, makamaka ngati zizindikiro za hypoglycemia sizikupezeka kapena zosakwaniritsidwa, kapena ngati kuchulukitsa kwa hypoglycemia kumachitika pafupipafupi. Zikatero, musayendetse.

Zotsatira zoyipa za Humulin.

Hypoglycemia ndiye njira imodzi yodziwika yomwe imathandizira kuti odwala matenda a shuga apatsidwe matenda a shuga. Hypoglycemia yamphamvu imatha kutha kwa chikumbumtima ndipo nthawi zina, amafa.

Matenda am'deralo amatha kuoneka ngati redness, kutupa, kapena kuyabwa pa malo a jakisoni. Nthawi zambiri zimakhala masiku angapo mpaka milungu ingapo. Nthawi zina, vutoli silimakhudzana ndi insulin, koma ndi zina, mwachitsanzo, ndi zosokoneza pakuphatikizidwa kwa oyeretsa khungu kapena kusadziwa bwino jakisoni.

Systemic ziwengo (zomwe sizachilendo koma zimakhala zowopsa kwambiri) ndi mawonekedwe a insulin omwe angayambitse totupa padziko lonse lapansi, kufupika, kupindika, kutsika magazi, kuchuluka kwa mtima, komanso thukuta. Milandu yambiri ya chifuwa chachikulu yomwe ikuluikulu imakhala pangozi. Nthawi zina mankhwalawa amapha kwambiri Humulin, njira zoyenera ziyenera kuchitidwa mwachangu. Pangakhale chifukwa china chofunikira choti insulini ithetse ena kapena ichotseretu mankhwala.

Lipodystrophy imatha kupezeka pamalo a jakisoni.

Kodi zimapangidwa bwanji?

Humulin M3 ya jekeseni subcutaneous kapena intramuscularly amapangidwa mwa njira yothetsera 10 ml. kwa makina a insulin kapena makatoni ogwiritsira ntchito zolembera, 1.5 kapena 3 mamililita, makapisozi asanu ali mumtundu umodzi. Makatoni angagwiritsidwe ntchito ndi zolembera za syringe kuchokera ku Humapen, BD-Pen.

Mankhwala amathandizira kuchepetsa kutsika kwa shuga mthupi la wodwala yemwe ali ndi matenda ashuga, amakhala ndi nthawi yayitali, ndipo ali osakaniza ndi insulin yochepa komanso yayitali. Pambuyo kugwiritsa ntchito Humulin ndikuyambitsa thupi, imayamba kuchita theka la ola pambuyo pobayidwa, mphamvu imatha kwa maola 18 mpaka 24, kutalika kwa zotsatirazi kumadalira zomwe zimachitika ndi matenda ashuga.

Zochita za mankhwalawa komanso nthawi yake zimasiyanasiyana malo a jakisoni, mlingo womwe adasankhidwa ndi adotolo, zolimbitsa thupi zokhudzana ndi wodwala pambuyo pakupereka mankhwala, zakudya, ndi zina zingapo.

Zochita za mankhwalawa zimakhudzana ndi kayendedwe ka kupindika kwa shuga m'thupi. Humulin imakhalanso ndi anabolic, chifukwa chomwe imagwiritsidwa ntchito popanga thupi.

Amasintha kayendedwe ka shuga ndi ma amino acid m'maselo a anthu, amalimbikitsa kutseguka kwa anabolic protein metabolism. Imalimbikitsa kutembenuka kwa glucose kukhala glycogen, linalake ndipo tikuthandizira kusintha kwa shuga m'thupi kukhala minofu ya adipose.

Zogwiritsidwa ntchito ndi kuthekera kwa zotsatira zoyipa

Humulin M3 imagwiritsidwa ntchito pochiza matenda osokoneza bongo a shuga (mellitus), momwe amachitira insulin.

Mwa zina zoyipa za mankhwalawa zimadziwika:

1. Milandu yodumpha mu shuga pansi pazomwe zimakhazikitsidwa - hypoglycemia,
2. Hypersensitivity pamagawo a mankhwala.

Nthawi zambiri amalemba milandu ya kuchepa kwambiri kwa shuga m'magazi atagwiritsa ntchito insulin, kuphatikizapo Humulin M3. Ngati wodwalayo ali ndi vuto lalikulu, kulumpha mu shuga kumapangitsa kuti pakhale kupweteka, kufa ndi kufa kwa wodwalayo ndikotheka.

Pokhudzana ndi hypersensitivity, odwala amatha kukumana ndi zovuta zonse, kufiyanso, kuyabwa, komanso khungu pakhungu.

Zotsatira zoyipa zambiri sizimapita palokha, pogwiritsira ntchito humulin yolimbana ndi mankhwalawa amatha kupita patatha masiku angapo jekeseni woyamba wa mankhwalawa pakhungu, nthawi zina chizolowezi chimachedwa mpaka milungu ingapo.

Odwala ena, matupi awo sagwirizana ndi mwachilengedwe, motero amakhala ndi zotsatirapo zowopsa:

• Kupezeka kwa mavuto kupuma,
• Tachycardia
• Kugwa kopsinjika ndi kufooka kwathupi,
• Mawonekedwe ofupika ndi thukuta,
• Kuyabwa kofananako pakhungu.

Nthawi zina, kusintha kwa thupi kumabweretsa chiopsezo pamoyo wa anthu komanso thanzi, chifukwa chake, ngati zizindikiro zomwe tafotokozazi zikuwoneka, ndikofunika kupempha thandizo kuchipatala msanga. Vutoli limathetsedwa ndikusintha insulin imodzi ndikukonzekera ina.

Njira yogwiritsira ntchito

Sizoletsedwa kupaka insulin pokonzekera, jakisoni amapangidwira kokha.

Lingaliro logwiritsira ntchito insulin limapangidwa ndi adokotala, pomwe jekeseni ndi pafupipafupi pakukhazikitsa mankhwalawa amasankhidwa payekhapayekha kwa wodwala aliyense, mlingo umadalira kuchuluka kwa shuga m'magazi a wodwala.

Kukhazikitsidwa kwa insulin kumachitika mu chipatala moyang'aniridwa ndi endocrinologist ndi muyeso wopitilira muyeso wamagazi kuzungulira wotchi.

Pankhani yogwiritsa ntchito koyamba, dokotalayo amalankhula za njira zoperekera insulin, komanso malo omwe angathe, nthawi zina, kuyikiridwa kwa mankhwalawa kwakuloledwa.

Mankhwalawa amalowetsedwa m'mimba, matako, m'chiuno kapena m'mapewa. Ndikofunikira kuti musinthe malo a jakisoni nthawi ndi nthawi kuti muchepetse kukula kwa lipodystrophy. Kuchita mwachangu kwambiri kwa insulin kumachitika pambuyo pa jakisoni m'mimba.

Kutengera ndi kutalika kwa singano, insulin imayendetsedwa mosiyanasiyana:

• Singano zazifupi (4-5 mm) - pamakona madigiri 90 mwa kuyambitsa mwachindunji popanda makwinya pakhungu.
• Singano zapakatikati (6-8 mm) - pakona madigiri 90, khola limapangidwa pakhungu,
• Kutalika (kupitirira 8 mm) - pa ngodya ya madigiri 45 ndi khola pakhungu.

Kusankha koyenera kwamakona kumakupatsani mwayi wopewa kukonzekera kwa insulin. Anthu odwala matenda ashuga omwe ali ndi mbiri yayitali ya matendawa amagwiritsa ntchito singano mopitilira 12 mm, kwa ana ndikofunikira kupanga jakisoni ndi singano yoposa 4-5 mm.

Mukakonza jakisoni, musalole kuti singano ilowe m'mitsempha yamagazi, apo ayi, kuphulika kungachitike pamalo operekera jakisoni. Kuwononga tsamba la jakisoni sikuloledwa.

Mankhwala Humulin M3 - chisakanizo cha insulin Humulin NPH ndi Humulin pafupipafupi, ndizothandiza chifukwa sizifunika kuti wodwalayo azikonzekera payekha asanagwiritse ntchito.

Musanagwiritse ntchito, vial kapena cartridge yokhala ndi insulini iyenera kukonzedwa - imapakidwa mosamala mmanja mwanu nthawi 10 ndikukatembenuka kangapo madigiri a 180, izi zimakupatsani mwayi woyimitsidwa. Ngati, atatha kusakaniza kwa nthawi yayitali, mankhwalawo samakhala opanda magazi ndipo maonekedwe oyera oyera akuwonekera, insulini idachepa.

Musagwedezere insulin yayitali kwambiri mwachangu, chifukwa izi zidzakuthandizani kuti mupange chithovu ndipo zingakuthandizeni kupewa kusankha mankhwalawo.

Mukangokonzekera lokha, tsamba la jakisheni limakonzedwa. Wodwala ayenera kusamba m'manja mosamala, kuchiza jakisoni ndi kupukuta kwapadera kwa mowa, izi zimagulidwa mosavuta ku pharmacy iliyonse.

Kuchuluka kwa insulin kumakokedwa mu syringe (ngati cholembera chikagwiritsidwa ntchito, mlingo umasankhidwa pogwiritsa ntchito chosinthika), kapu yoteteza imachotsedwa ndipo jakisoni amapangidwa khungu. Osatulutsa singano mwachangu kwambiri, tsamba la jekeseni pambuyo pa jakisoni liyenera kukanikizidwa ndi chopukutira.

Migwirizano yogulitsa ndikusunga

Mutha kugula insulin mukafamu ya mankhwala ngati muli ndi mankhwala ovomerezeka kuchokera kwa dokotala.

Ndikofunika kusunga mankhwalawo mufiriji kutentha kwa madigiri 2 mpaka 8 Celsius, osatulutsa mankhwalawo kuzizirira, komanso kuyamwa kapena kutentha. Insulin yotseguka imatha kusungidwa pamtunda wa 15 mpaka 25 madigiri osaposa masiku 28.

Ngati zinthu zonse zosungirako zakwaniritsidwa, moyo wa alumali ndi zaka 3 kuyambira tsiku lopangidwa. Ndi zoletsedwa kugwiritsa ntchito mankhwala omwe atha, pakadali pano sikukhudza thupi, pakavulaza kuyambitsa poizoni wakupha kwambiri.

Musanagwiritse ntchito, ndikofunika kuchotsa Humulin M3 mufiriji mu mphindi 20-30. Jakisoni wa mankhwala ofunda firiji amachepetsa ululu.

Onetsetsani kuti nthawi yakwanira isanayambe.

Kugwiritsa ntchito Humulin M3 pa nthawi yapakati komanso yoyamwitsa

Pa nthawi yoyembekezera, azimayi omwe ali ndi matenda ashuga amayenera kuyang'anira shuga wawo wamagazi. Kufunika kwa kusintha kwa insulin kutengera nthawi yomwe mayi ali ndi pakati, chifukwa chake, mkati mwa trimester yoyamba, imagwera, nthawi yachiwiri ndi yachitatu - imawonjezeka. Ichi ndichifukwa chake miyeso imafunikira jekeseni iliyonse isanachitike. Pa nthawi yoyembekezera, mlingo umatha kusinthidwa kangapo.

Kusintha kwa mankhwalawa kungafunike pakuyamwa. Dokotala wopezekapo amayenera kulingalira za thanzi la mayi wachichepere komanso kuchuluka kwa zolimbitsa thupi.

Mlingo wosankhidwa bwino amalola kugwiritsa ntchito Humulin M3 pochiza matenda a shuga. Malinga ndi odwala, ndi Humulin yomwe imagwira ntchito kwambiri ndipo sikuti imakhala ndi zotsatirapo zonse pazogwiritsidwa ntchito.

Kumbukirani kuti kudzipereka ndi insulin nokha kumapangidwa, chifukwa izi zimatha kupha. Kusintha kwa mlingo uliwonse komanso kusintha kwa analogues kumachitika pamaso pa adotolo ndikuwonetsetsa kuchuluka kwa shuga m'magazi.