Momwe mungawerengere kuchuluka kwa Amoxiclav 125, 250, 375 ndi 400 mg kwa ana: malangizo ogwiritsira ntchito kuyimitsidwa ndi mapiritsi

Amoxiclav ® ndi kuphatikiza kwa amoxicillin - semisynthetic penicillin wokhala ndi zochita zambiri za antibacterial ndi clavulanic acid - choletsa chosasintha cha β-lactamases. Clavulanic acid imakhala yovuta kukhazikika nayo michere iyi ndikuwonetsetsa kukana kwa amoxicillin pazotsatira za β-lactamases zopangidwa ndi tizilombo.

Clavulanic acid, yofanana ndi mankhwala a beta-lactam, ali ndi mphamvu yofooka ya antibacterial.

Amoxiclav ® ili ndi mawonekedwe osiyanasiyana a antibacterial action.

Yogwira Amoxicillin tinthu tating'ono, kuphatikizapo β-lactamase yopanga tizilombo ta, kuphatikizapo mabakiteriya a grobic oyipa: Streptococcus pneumoniae, Streptococcus pyogenes, Streptococcus viridans, Streptococcus bovis, Staphylococcus aureus (kupatula mitsempha yoletsa methicillin), Staphylococcus epidermidis (kupatula mitsempha yolimbana ndi methicillin), Staphylococcus saprophyo mabakiteriya olakwika a grobic: Bordetella pertussis, Brucella spp., Campylobacter jejuni, Escherichia coli, Gardnerella vaginalis, Haemophilus influenzae, Haemophilus ducreyi, Klebsiella spp., Moraxella catarrhalis, Pippis neisseria gonorrhoeae Somppella meppida Vibrio cholerae, Yersinia enterocolitica, Helicobacter pylori, Eikenella corrodens, mabakiteriya a anaerobic gramu: Peptococcus spp., Peptostreptococcus spp., Clostridium spp., Actinomyces israelii, Fusobacterium spp., Prevotella spp., anaerobes osavomerezeka: Bacteroides spp.

Pharmacokinetics

Magawo akuluakulu a pharmacokinetic a amoxicillin ndi clavulanic acid ndi ofanana.

Zonsezi zimapangidwa bwino mutatha kumwa mankhwalawo mkati, kudya sikumakhudza kuchuluka kwa mayamwidwe. C_max mu madzi am`magazi zimatheka 1 ola pambuyo makonzedwe. Makhalidwe a C_max pangani amoxicillin (kutengera mlingo) 3-12 μg / ml, wa clavulanic acid - pafupifupi 2 μg / ml.

Zonsezi zimadziwika ndi kuchuluka kogawika m'madzi amthupi ndi minyewa (mapapu, khutu lapakati, zotulutsa ndi zotumphukira za m'chiberekero, chiberekero, mazira, ndi zina). Amoxicillin imalowanso madzi ophatikizika a chiwindi, chiwindi, matumbo a prostate, minofu ya palatine, minofu ya minyewa, chikhodzodzo, kutsekeka kwa mphuno, malovu, kubisala kwa bronchial.

Amoxicillin ndi clavulanic acid simalowa BBB ndi mauna osavulala.

Amoxicillin ndi clavulanic acid amadutsa chopinga ndipo amachotseredwa mkaka wa m'mawere mosiyanasiyana. Amoxicillin ndi clavulanic acid amadziwika ndi zomanga zochepa m'mapuloteni a plasma.

Amoxicillin amaphatikizidwa pang'ono, asidi clavulanic mwachidziwikire amatha kuyamwa kwambiri.

Amoxicillin amachotseredwa ndi impso pafupifupi osasinthika ndi kubisala kwa tubular ndi kusefera kwa glomerular. Clavulanic acid imapukusidwa ndi kusefera kwa glomerular, mwanjira ina ya metabolites. Zing'onozing'ono zimatha kupukusidwa kudzera m'matumbo ndi m'mapapu. T_1/2 amoxicillin ndi clavulanic acid ndi maola 1-1,5

Pharmacokinetics mu milandu yapadera yamankhwala

A kwambiri aimpso kulephera T_1/2 ukuwonjezeka mpaka maola 7.5 a amoxicillin ndi maola 4.5 a clavulanic acid. Zonsezi zimachotsedwa ndi hemodialysis ndi zochepa zazing'ono ndi peritoneal dialysis.

Matenda oyambitsidwa ndi tizilombo tating'onoting'ono tating'ono:

- matenda am'mimba kupuma kwamatumbo ndi ziwalo za ENT (kuphatikizapo pachimake ndi matenda osachiritsika, matenda oopsa komanso otitis, pharyngeal abscess, tonsillitis, pharyngitis),

- matenda am'munsi kupuma thirakiti (kuphatikizapo pachimake bronchitis ndi bakiteriya wamphamvu, chifuwa, chibayo),

Matenda amitsempha

- matenda a pakhungu ndi minofu yofewa, kuphatikiza kulumidwa kwanyama ndi anthu,

- Matenda a mafupa ndi zotumphukira,

- matenda a biliary thirakiti (cholecystitis, cholangitis),

Contraindication

- Hypersensitivity ku zilizonse za mankhwala,

- Hypersensitivity m'mbiri mpaka penicillin, cephalosporins ndi mankhwala ena a beta-lactam,

- mbiri yakuwonetsa kwa cholestatic jaundice komanso / kapena chiwindi china chodwala chomwe chimayamba chifukwa chokhazikitsidwa ndi amoxicillin / clavulanic acid,

- Matenda a mononucleosis ndi khansa ya m'mimba.

Ndi kusamala Mankhwala ayenera kugwiritsidwa ntchito ndi mbiri ya pseudomembranous colitis, chiwindi kulephera, kwambiri aimpso kuwonongeka, komanso pa mkaka wa m`mawere.

Zotsatira zoyipa

Zotsatira zoyipa nthawi zambiri zimakhala zofatsa komanso zosakhalitsa.

Kuchokera m'mimba: kuchepa kwa chilala, kusanza, kusanza, kutsegula m'mimba, kuwonda m'mimba, kuwonjezeka kwa chiwindi michere (ALT kapena AST), munthawi zina - cholestatic jaundice, hepatitis, pseudomembranous colitis.

Zotsatira zoyipa: pruritus, urticaria, erythematous zidzolo, kawirikawiri - multiforme exudative erythema, angioedema, anaphylactic shock, allergic vasculitis, kawirikawiri - exfoliative dermatitis, Stevens-Johnson syndrome, pachimake chachikulu pantulosis.

Kuchokera ku hemopoietic dongosolo ndi dongosolo la lymphatic: kawirikawiri - kusintha kwa leukopenia (kuphatikizapo neutropenia), thrombocytopenia, kawirikawiri - hemolytic kuchepa magazi, kuwonjezereka kwa prothrombin nthawi (ikaphatikizidwa ndi anticoagulants), eosinophilia, pancytopenia.

Kuchokera ku dongosolo lamanjenje: chizungulire, kupweteka mutu, kawirikawiri - kukomoka (kumachitika mwa odwala omwe ali ndi vuto laimpso pakumwa mankhwalawa kwambiri), kuchepa mtima, nkhawa, kusowa tulo.

Kuchokera pamikodzo: kawirikawiri - interstitial nephritis, crystalluria.

Zina: osati kawirikawiri - kukulitsa kwa superinitness (kuphatikizapo candidiasis).

Bongo

Palibe malipoti a imfa kapena zovuta zoyipa chifukwa cha mankhwala osokoneza bongo.

Zizindikiro Nthawi zambiri, kusokonezeka kwa m'mimba thirakiti (kupweteka kwam'mimba, kutsegula m'mimba, kusanza), kuda nkhawa, kusowa tulo, chizungulire ndizothekanso, ndipo nthawi zina kumugwira ndikumugwira.

Chithandizo: wodwalayo ayenera kuyang'aniridwa ndi achipatala, a dalili. Pankhani ya mankhwalawa posachedwa a mankhwalawa (osachepera maola 4), ndikofunikira kutsuka m'mimba ndikuwapatsa mpweya woyambitsa kuti muchepetse kuyamwa kwa mankhwalawa. Amoxicillin / potaziyamu clavunate amachotsedwa ndi hemodialysis.

Malangizo apadera

Ndi njira ya chithandizo, ntchito za magazi, chiwindi ndi impso ziyenera kuyang'aniridwa.

Odwala kwambiri mkhutu aimpso ntchito, kukonzekera koyenera wa dosing regimen kapena kuwonjezeka kwa pakati pakati pa dosing kumafunika.

Pofuna kuchepetsa chiopsezo cha zovuta m'matumbo, mankhwalawa amayenera kumwa ndi zakudya.

Kuyeserera kwa Laborator: kuchuluka kwa amoxicillin kumapereka malingaliro abodza pamkodzo wa glucose mukamagwiritsa ntchito njira ya Benedict kapena Reelling's. Enzymatic zimachitikira ndi glucosidase tikulimbikitsidwa.

Kukopa pa kuyendetsa magalimoto ndi kayendedwe kazinthu

Palibe deta pazovuta za Amoxiclav mu Mlingo wolimbikitsidwa pa kuyendetsa galimoto kapena kugwira ntchito ndi makina.

Kuyanjana kwa mankhwala osokoneza bongo

Ndi munthawi yomweyo kugwiritsa ntchito mankhwala Amoxiclav ® ndi ma antacid, glucosamine, mankhwala othandizira, aminoglycosides, mayamwidwe amachepetsa, ndi ascorbic acid - amawonjezeka.

Ma diuretics, allopurinol, phenylbutazone, NSAIDs ndi mankhwala ena omwe amatseka kubisalira kwa tubular kumawonjezera kuchuluka kwa amoxicillin (clavulanic acid imachotsedwa makamaka ndi kusefera kwa glomerular).

Ndi munthawi yomweyo kugwiritsa ntchito Amoxiclav ® kumawonjezera kawopsedwe a methotrexate.

Pogwiritsa ntchito munthawi yomweyo Amoxiclav ndi allopurinol, zochitika za exanthema zimawonjezeka.

Makonzedwe oyanjana ndi disulfiram ayenera kupewedwa.

Nthawi zina, kumwa mankhwalawa kungakulitse nthawi ya prothrombin, motere, kusamala kuyenera kuchitidwa popereka mankhwala anticoagulants ndi mankhwala Amoxiclav ®.

Kuphatikiza kwa amoxicillin ndi rifampicin ndikutsutsana (pali kufooka kwa mphamvu ya antibacterial).

Amoxiclav ® sayenera kugwiritsidwa ntchito nthawi imodzi ndi mankhwala opatsirana a bacteriostatic (macrolides, tetracyclines), sulfonamides chifukwa cha kuchepa kwa mphamvu ya Amoxiclav.

Probenecid amachepetsa kupukusira kwa amoxicillin, kukulitsa kuchuluka kwake kwa seramu.

Maantibayotiki amathandizira kuchepetsa kupatsirana kwa pakamwa.

Njira yogwiritsira ntchito

Mlingo watsiku ndi tsiku wa kuyimitsidwa 125 mg + 31.25 mg / 5 ml ndi 250 mg + 62,5 mg / 5 ml (kuti muthandizire kuyimitsidwa koyenera kwa kuyimitsidwa kwa 125 mg + 31.25 mg / 5 ml ndi 250 mg + 62,5 mg / 5 ml ya kuyimitsidwa pamaphukusi aliwonse, supuni ya mulingo wokhala ndi mphamvu ya 5 ml kapena piritsi yotsirizidwa imayikidwa).

Makanda obadwa kumene ndi ana mpaka miyezi itatu sankha 30 mg / kg (amoxicillin) / tsiku, logawidwa mu 2 Mlingo (uliwonse maora 12), ana opitilira miyezi itatu - kuchokera 20 mg (amooticillin) / kg / tsiku pa matendawofatsa pang'ono mpaka 40 mg / kg (malinga ndi amoxicillin) / tsiku pa matenda oopsa komanso matenda opatsirana thirakiti yogawidwa 3 Mlingo uliwonse (maola 8 aliwonse).

Mlingo wolimbikitsidwa malinga ndi kuchuluka kwa thupi la mwanayo komanso kuopsa kwa matendawa.

Mlingo watsiku ndi tsiku wa kuyimitsidwa 400 mg + 57 mg / 5 ml amawerengedwa pa kilogalamu imodzi ya kulemera kwa thupi malinga ndi kuopsa kwa matendawa ndipo 25 255 mg / kg thupi / tsiku (malinga ndi amoxicillin), logawidwa mu 2 waukulu.

Kuwongolera dosing yoyenera, kuyimitsidwa kwa 400 mg + 57 mg / 5 ml ndikuyikidwa mu phukusi lirilonse la pipette ya mlingo, omaliza nthawi imodzi mu 1, 2, 3, 4, 5 ml ndi magawo 4 ofanana.

Mlingo wovomerezeka woyenera kutengera thupi la mwanayo komanso kuopsa kwa matendawa.

Mlingo wofanana watsiku ndi tsiku amawerengedwa potengera thupi la mwana, osati zaka zake.

Mulingo wambiri watsiku ndi tsiku wa amoxicillin ndi Za akulu 6 g chifukwa ana - 45 mg / kg kulemera kwa thupi.

Mlingo wambiri watsiku ndi tsiku wa clavulanic acid (mwa mchere wa potaziyamu) ndi Za akulu 600 mg kwa ana - 10 mg / kg thupi.

At odwala kwambiri aimpso kulephera (CC zosakwana 10 ml / min) Mlingo uyenera kuchepetsedwa mokwanira kapena pakati pakati Mlingo wambiri uyenera kuchuluka (ndi anuria mpaka maola 48 kapena kupitilira).

Njira ya mankhwala ndi masiku 5-14. Kutalika kwa nthawi ya chithandizo akutsimikiza ndi dokotala. Kuchiza sikuyenera kupitirira masiku opitilira 14 popanda kupimidwa kachiwiri.

Malamulo pokonzekera kuyimitsidwa

Ufa pakukonzekera kuyimitsidwa kwa 125 mg + 31.25 mg / 5 ml: gwedezani botolo mwamphamvu, onjezerani madzi a 86 ml (pamalowo) mu milingo iwiri, nthawi iliyonse kugwedezeka bwino mpaka ufa utasungunuka kwathunthu.

Ufa pakukonzekera kuyimitsidwa kwa 250 mg + 62,5 mg / 5 ml: gwedezani botolo mwamphamvu, onjezerani 85 ml ya madzi (mpaka chizindikiro) mumiyeso iwiri, nthawi iliyonse kugwedezeka bwino mpaka ufa utasungunuka kwathunthu.

Ufa pakukonzekera kuyimitsidwa kwa 400 mg + 57 mg / 5 ml: gwiritsani botolo mwamphamvu, onjezerani madzi mu kuchuluka kosonyezedwa ndikulembedwera tebulo (mpaka chizindikiro) mumadontho awiri, nthawi iliyonse kugwedezeka bwino mpaka ufa utatha.

Musanagwiritse ntchito, vial ayenera kugwedezeka mwamphamvu.

Amoxiclav: mawonekedwe ndi mawonekedwe ogwiritsira ntchito

Amoxiclav ndi mankhwala osakanikirana omwe angatengedwe kuchiza matenda osiyanasiyana, kuyambira bronchitis ndikutha ndi mavuto a impso. Zomwe zimagwiritsa ntchito mankhwalawa ndi:

Zigawo zothandiza za Amoxiclav ndi monga:

• Na citrate
• citric acid
• xanthan chingamu,
• Na benzoate,
• colloidal silicon dioxide,
• carmellose Na,
• Na saccharin,
• kulawa (chitumbuwa, sitiroberi, ndimu),
• mannitol.

Maantibayotiki amaikidwa pokhapokha ngati chifukwa cha matendawa ndi bacteria wovulaza. Amoxiclav kwa ana ndi akulu amamulembera matenda am'mimba komanso am'munsi kupuma ndi ziwalo za ENT. Njira zotupa monga izi:

• tonillitis (tonsillitis),
• sinusitis pachimake kapena matenda,
• pachimake otitis media
• pharyngitis
• pyelonephritis,
• pharyngeal chotupa,
• sinusitis
• bronchitis
• chibayo

Kugwiritsa ntchito maantibayotiki ndikofunikira pa:

Njira yotulutsira: kuyimitsidwa ndi mapiritsi

Makampani ogulitsa zamankhwala amapereka kwa ogula mitundu iwiri ya kutulutsira mankhwala a antibacterial. Loyamba ndi mapiritsi. Ndi yoyenera kwa akuluakulu. Ubwino wabwino wa fomu iyi ndikuti mapiritsi ndi osavuta kugwiritsa ntchito kulikonse, kuyang'anira njira yolandirira. Amapezeka mu Mlingo wa 250 ndi 500 mg wa amoxicillin ndi 125 mg ya clavulanic acid. Mu chithuza - mapiritsi 15 kapena 20.

Mtundu wachiwiri wa kumasulidwa ndi ufa womwe kuyimitsako kumakonzedwa. Ndikwabwino kuti mwana akhale ndi amoxiclav mwanjira imeneyi, makamaka kwa iwo omwe sakudziwa kutafuna kapena kumeza mapiritsi.

Gome ili pansipa likuwonetsa kuchuluka komwe Amoxiclav ufa wa ana amapangidwa:

Ufa ndi kuyimitsidwa okonzedwa ndi zoyera kapena zachikaso zoyera. Chogulikacho chimapezeka mumbale zamagalasi akuda okhala ndi voliyumu ya 100 ml. Mu botolo la 25 magalamu a ufa. Phukusi limakhala ndi supuni yoyesera kapena pipette. Momwe mungakonzekere kuyimitsidwa, mutha kuwerengera malangizo omwe aphatikizidwa ndikuyang'ana kanema wa nkhaniyo ndi-algorithm yatsatanetsatane.

Momwe mungawerengere kuchuluka kwa mankhwalawa?

Kuti mupeze zotsatira zabwino zothana ndi maantibayotiki ndikuchepetsa zovuta zake, muyenera kudziwa mlingo wa mankhwalawo ndikuwonjezera madzi ndikumupatsa mwana madzi kapena mapiritsi kuti amwe.

Kuti muwerenge molondola kutumiza kamodzi kwa Amoxiclav, mfundo izi zikuyenera kuganiziridwa:

• m'badwo wa mwana
• kulemera kwa wodwala pang'ono
• matenda
• kuopsa kwa matendawa.

Kwa ana kuyambira miyezi isanu mpaka zaka khumi ndi zovuta za nthawi yopatsirana, ndikokwanira kuchepetsa ufa ndi mulingo wa 125 mg. Ngati angina, chibayo kapena matenda ena ndi zovuta, ndiye kuti mankhwala amathandizidwa ndi antibacterial yogwira mu 250 kapena 400 mg.

Kuyimitsidwa - kwa ana osakwana zaka khumi ndi ziwiri

Mukamagwiritsa ntchito mawonekedwe a ufa, gawo loyamba ndikukonzekera kuyimitsidwa. Kuti muchite izi, thirani ufa ndi madzi m'botolo ku zoopsa zomwe zilipo pagalasi lake. Madzi ayenera kuwiritsa ndi kuwiritsa. Pambuyo pa kusakaniza kuyenera kugwedezeka, kotero kuti kusakanikirana.Kuyimitsidwa okonzedweratu kumatha kusungidwa osapitilira sabata mufiriji.

Pogwiritsa ntchito supuni kapena syringe, pimani madzi ambiri. Zochuluka ndendende zomwe zimafunikira kupatsa madzi kwa mwana mpaka chaka chimodzi kapena mwana wamkulu amapezeka mu malangizo ogwiritsa ntchito. Ili ndi matebulo ndipo imafotokoza momwe mungagwiritsire ntchito mankhwalawa kuwerengera kuchuluka kwa mankhwalawo. Popereka mankhwala, dokotala amayenera kudziwa kuchuluka kwa mankhwalawo, makamaka chifukwa cha zaka ndi matenda, komanso kunena kuti ndi masiku angati omwe ayenera kumwa mankhwala a antibacterial.

Ngati mwana sanakwanitse miyezi itatu, ndiye kuti mlingo wa tsiku ndi tsiku ndi 30 mg wa kilogalamu imodzi ya kulemera kwa thupi. Mankhwala amatengedwa maola 12 aliwonse. Pambuyo pa miyezi itatu, mlingo ndi 20 mg pa kilogalamu, koma mankhwalawa amaperekedwa maola onse asanu ndi atatu. Izi zili ndi njira yofatsa kapena yodwala. Muzovuta kwambiri, zimachuluka mpaka 40 mg / kg ndi nthawi yomweyo.

Kuti zitheke, awa ndi miyeso ya kuyimitsidwa kwa Amoxiclav a mibadwo yosiyanasiyana m'masamba amphaka:

Mapiritsi - a ana okulirapo

Piritsi la antibacterial drug Amoxiclav lakonzedwa kuti likhale la akulu ndi ana opitilira zaka 12-14. Piritsi limodzi lili ndi 375 mg yogwira mankhwala. Amatengedwa katatu patsiku, piritsi limodzi.

Mlingo umasiyanasiyana malinga ndi momwe zinthu zilili. Ndi angina, ana amapatsidwa piritsi limodzi ndi maola 8, limodzi ndi matenda ena - maola 12 aliwonse. Muzovuta kwambiri, dokotala yemwe akupezekapo amatha kuwonjezera mlingo umodzi kuti akwaniritse mwachangu.

Momwe mungaperekere mankhwalawa kwa ana azaka zosiyanasiyana?

Ngakhale wodwala ali ndi zaka zingati, pali malamulo amomwe angatenge Amoxiclav:

1. Phwando ndi chakudya. Ngati mumwa mankhwalawo ndi chakudya, izi zimachepetsa kwambiri mavuto obwera chifukwa cha m'mimba.
2. Kukonzekera kuyimitsidwa musanagwiritse ntchito.
3. Kuyang'anira mkhalidwe wa mwana. Ndikofunika kuyang'anira mosamala kusintha konse komwe kuli mu mkhalidwe ndi momwe wodwalayo angakhalire, zabwino ndi zoipa. Ndi mawonekedwe owonetsa, muyenera kusiya kumwa mankhwalawo ndikupita kukaonana ndi katswiri.
4. Osasokoneza maphunziro. Zotsatira zake zimakhazikika pambuyo poti chithandizo chatha.
5. Sungani tsiku lotha ntchito. Ali ndi zaka 2. Kuyimitsidwa kwamaliridwe kumasungidwa mufiriji osapitilira masiku 7.
6. Tsatirani kuchuluka kwa mankhwala.
7. Kuwongolera mkhalidwe wa impso, chiwindi ndi magazi.

Ndi kufatsa pang'ono komanso pang'ono

Kuchuluka kwa mankhwalawa omwe amalembedwa m'njira zambiri samatsimikizira zaka za wodwalayo, koma thupi lake, chifukwa ana onse ndi osiyana, ndipo kulemera kwawo pamsinkhu womwewo kumatha kusiyanasiyana. Komabe, kuopsa kwa matendawa kumathandizanso kwambiri mu antiim regimen.

Ponena za mitundu yofatsa komanso yodalirika ya matendawa, ndiye kuti chiwembu chofunikira chikugwiranso ntchito. Kuyimitsidwa kwa 125 kapena 250 ml kwakhazikitsidwa katatu patsiku. M`pofunika kumwa antibacterial mankhwala kwa masiku 5-7. Zowona, zili kwa dokotala kusankha izi. Osangoyimira pawokha nthawi, kuchuluka kapena kuchuluka kwa tsiku lililonse. Ndizowopsa ndikuwopseza zovuta. Ngati vutoli silikupezeka ndi mtundu wosankhidwa wa mankhwala, ndiye kuti mankhwalawo siabwino kulimbana ndi matenda enaake.

Woopsa matenda

Potengera ndi zovuta zamomwe timayendedwe a pathological, mawonekedwe amasintha. Mankhwala, kuyimitsidwa ndi antibacterial okwana 400 mg ndi komwe kumakondedwa. Amauzidwanso kumwa katatu patsiku. Chithandizocho chikuyang'aniridwa ndi adokotala. Pokhapokha ndi chilolezo chake pomwe angasinthe. Mwachitsanzo, kuchuluka kwa tsiku ndi tsiku kumawonjezeka ndi wachitatu kuchokera ku njira yokhazikika. Njira yamankhwala imatha kupitilira milungu iwiri. Mwa izi, mkhalidwe wa wodwala umagwira ntchito yofunika.

Zotsatira zoyipa ndi zovuta zotheka ndi ziti?

Mankhwala a antibacterial ndi chida chothandiza chomwe chimapereka mphamvu mwachangu. Pali mbali yolakwika - mndandanda wochititsa chidwi wa zomwe zimachitika. Zotsatira zoyipa za mankhwala a Amoxiclav nthawi zambiri zimakhudza ntchito ya m'mimba ndipo amadziwonetsa ngati ziwopsezo. Poyambirira, mwana ali:

• kusadya bwino
• kusanza
• nseru
• kutsegula m'mimba
• dysbiosis.

Nthawi zambiri, kumwa Amoxiclav kumayendera limodzi ndi kupweteka pamimba, colitis, chiwindi, hepatitis, jaundice. Ponena za matupi awo sagwirizana, amadziwoneka ngati:

Kuphatikiza pazizindikiro zoyipa zomwe zili pamwambapa, machitidwe ena a thupi amathanso kukhudzidwa ndi zovuta: hematopoietic, lymphatic, kwamikodzo komanso dongosolo lamanjenje. Mwanayo akuonekera:

• thrombocytopenia
• leukopenia
• kuchepa magazi
• eosinophilia
• pancytopenia
• khalid
• interstitial nephritis,
• chizungulire
• mutu
• Hyperacaction
• zosokoneza tulo
• kuda nkhawa kwambiri
• kukokana.

Dzinalo

Dzina lachi Russia la mankhwalawo ndi Amoxiclav, Latin - Amoksiklav.

Khodi yamankhwala mu gulu la ATX (anatomical-Therapeutic-chemical) ndi J01CR02.

Amoxiclav ndi mankhwala ophatikiza ndi gulu la ma penicillin otetezedwa.

Kutulutsa mafomu ndi kapangidwe kake

Amoxiclav 400 mg amagulitsidwa mu mawonekedwe a ufa, omwe amawumitsidwa kuti apeze kuyimitsidwa. The ufa ndi loyera kapena pang'ono chikasu. The yogwira mankhwala (amoxicillin) lilipo mu mawonekedwe a trihydrate. Kuchuluka kwa potaziyamu beta-lactamase inhibitor ndi 57 mg. Pamodzi ndi antibacterial wothandizila, kapangidwe ka ufa umaphatikizira chingamu, sodium benzoate, citric acid, mannitol, flavorings, silicon dioxide ndi zinthu zina. Ufa umayikidwa m'mabotolo (ndi pipette) ndi mapaketi a makatoni.

Zizindikiro zogwiritsidwa ntchito

Amoxiclav 400 adalembedwa zotsatirazi matenda:

1. Matenda a ziwalo za ENT komanso kupumira kwapamwamba (otitis media, kuwonongeka kwa ma sinuses, pharyngeal abscess, kutupa kwa toni, larynx ndi pharynx).
2. Kutupa kwa mapapu ndi bronchi.
3. Matenda opatsirana a genitourinary ziwalo (urethritis, cystitis, kutupa kwa impso, endometritis, kuwonongeka kwa ziwalo za uterine, vulvovaginitis).
4. Matenda a mafupa (osteomyelitis) ndi minofu yolumikizana.
5. Kutupa kwa ndulu ndi ma ducts a bile.
6. Kulumwa nyama.
7. Matenda a pakhungu (pyoderma).
8. Matenda a Odontogenic kumbuyo kwa kuwonongeka kwa mano.

Amoxiclav 400 adalembedwa matenda a ziwalo za ENT ndi kupuma kwapadera thirakiti.
Mankhwala osokoneza bongo adafotokozedwa mankhwalawa matenda opatsirana a matenda amtundu wamkati (urethritis, cystitis, kutupa kwa impso, endometritis, kuwonongeka kwa ziwalo za uterine, vulvovaginitis).
Matenda a mafupa ndi osakanikirana minofu amapatsidwa zochizira Amoxiclav 400.
Ndi kutupa kwa ndulu ndi michere ya bile, maantibayotiki ndi mankhwala.
Amoxiclav amalembera kulumwa nyama.
Mankhwalawa amapatsidwa mankhwala opatsirana pakhungu (pyoderma).
Ndi kutupa kwamapapu ndi bronchi, maantibayotiki ndi mankhwala.

Mankhwalawa amagwiritsidwa ntchito kwambiri mu obstetrics ndi gynecology.

Momwe mungatenge Amoxiclav 400

Mukamapereka mankhwala othandizira kuti alandire, mawonekedwe azaka za odwala ndi omwe ali ndi vutoli amakhudzidwa.

Mlingo wa akuluakulu ndi 25-45 mg / kg. Mlingo wa mankhwalawa ukhoza kufika 2,085 mg. Phukusili limakhala ndi supuni yoyesera ndi voliyumu ya 5 ml kapena pipette yomaliza. Mlingo wambiri (wa amoxicillin) ndi 6 g. Mankhwalawa amatengedwa kawiri patsiku ndi zakudya.

Mlingo wa ana

Kwa ana kuyambira miyezi itatu mpaka chaka masekeli 5 mpaka 10, mankhwalawa ndi mankhwala ¼ kapena ½ pipette, malingana ndi kuopsa kwa matendawa kawiri pa tsiku. Kwa ana a zaka zakubadwa 1-2 ndi masekeli 10-15, mulingo woyenera umachokera ku ½ mpaka ¾ ma papa. Ana omwe ali ndi zaka 2-3 ndi kulemera kwa 15-20 makilogalamu amawayikira kuchokera ku ¾ mpaka 1 unit. 2 pa tsiku. Chizindikiro chachikulu chowerengera si m'badwo, koma kulemera kwa mwana.

Chowerengetsera chachikulu cha kuchuluka kwa mankhwalawa si m'badwo, koma kulemera kwa mwana.

Matumbo

Mukamamwa mankhwalawa, zizindikiro za kuwonongeka kwa kugaya kwam'mimba (mseru, kusowa kwa chakudya, mapando otayirira mwachangu, kupweteka pamimba, kusanza) ndizotheka. M'mavuto akulu, pali:

1. Jaundice Imachitika chifukwa cha kusayenda kwa ndulu.
2. Hepatitis.
3. Pseudomembranous colitis.
4. Kuchuluka kwa chiwindi michere (ALT ndi AST).

Chimodzi mwazotsatira zoyipa za kumwa mankhwalawa ndi kukula kwa chiwindi.
Pseudomembranous colitis ndi chimodzi mwazinthu zoyambitsa kugwiritsidwa ntchito kwa Amoxiclav.
Woopsa, pali kuwonjezeka kwa michere ya chiwindi.
Mukamamwa maantibayotiki muzoopsa, jaundice amawonekera.
Mukamamwa mankhwalawa, zizindikiro za kuwonongeka kwa ziwalo zam'mimba (nseru, kusowa kwa chakudya) ndizotheka.

Kuchokera kwamikodzo

Odwala ena amatenga nephritis (kutupa kwa impso). Mchere wambiri ungawonekere mkodzo.

Mukamagwiritsa ntchito Amoxiclav, zimachitika matupi awo sagwirizana (redness of the khungu, papular zotupa za mtundu wa urticaria, kuyabwa, angioedema, dermatitis, manjenje ndi matenda a Stevens-Johnson).

Mukamagwiritsa ntchito Amoxiclav, zimachitika zovuta zamkati (khungu rede, zotupa za papular zamtundu wa urticaria, kuyabwa, ndi zina).

Kuchita ndi mankhwala ena

Kugwiritsa ntchito pamodzi kwa Amoxiclav 400 ndi ma antacid, glucosamine-based chondroprotectors, aminoglycosides, kulera kwamlomo, methotrexate, allopurinol, disulfiram, anticoagulants, macrolides, mankhwala ochokera ku gulu la tetracycline ndi sulfonamides osavomerezeka. Imachepetsa ndende ya Amoxiclav Probenecid.

Kuwonjezeka kwa kuchuluka kwa amoxiclav m'magazi kumalimbikitsidwa ndi:

Ma Amoxiclav 400 ma analogi ndi Amoxiclav Quiktab ndi Augmentin (yankho la jakisoni atha kukonzekera kuchokera pamenepo).

Analogue ya Amoxiclav 400 ndi Augmentin.

Tsiku lotha ntchito

Ufa umasungidwa kwa zaka ziwiri kuyambira tsiku lakonzekera. Kuyimitsidwa kotsirizika ndikoyenera kwa sabata ngati kwasungidwa mufiriji kutentha kwa + 2 ... + 8ºC mu botolo lotsekedwa.

Ndemanga za Dokotala za mankhwala a Amoxiclav: zikuonetsa, kutsimikiza, zotsatira zake, malangizo a Amoxiclav ogwiritsira ntchito mapiritsi a Amoxiclav Amoxiclav | analogi

Ndemanga za Amoxiclav 400

Ndemanga za akatswiri ndi anthu omwe adagwiritsa ntchito mankhwalawa ndizabwino kwambiri.

Yuri, wazaka 47, Kostroma: “Amoxiclav imakonda kuperekedwa kwa odwala anga omwe ali ndi matenda otupa a ziwalo zoberekera za akazi. Mankhwalawa ndi othandizadi kutsatira malamulo a ukhondo wachikazi. ”

Valery, wazaka 32, Vorkuta: “Amoxiclav amathandizanso ku matenda a ziwalo za ENT, kuphatikizapo khutu lapakati. Mankhwalawa ndi otsika mtengo ndipo samapereka zotsatira zoyipa. "

Alena, wazaka 28, ku Moscow: “Mwana wazaka 4 zakubadwa wapezeka ndi matenda oopsa a bronchitis. Ankachita ndi Amoxiclav 400 mu mawonekedwe a ufa. Chida chabwino. ”

Fomu ya Mlingo:

ufa kuyimitsidwa pakamwa.

Mlingo uliwonse wa 5 ml wa kuyimitsidwa kwa 400 mg + 57 mg / 5 ml uli ndi:
ntchito: amoxicillin (mu mawonekedwe a trihydrate) mogwirizana ndi yogwira - 400 mg, clavulanic acid (mu mawonekedwe a mchere wa potaziyamu) malinga ndi zomwe zimagwira - 57 mg, zokopa: citric acid (anhydrous) - 2.694 mg, sodium citrate (anhydrous) - 8.335 mg, cellcrystalline cellulose ndi sodium carmellose - 28.1 mg, xanthan chingamu - 10,0 mg, colloidal silicon dioxide - 16,667 mg, silicon dioxide - 0,217 g, kulawa kwamaso amtchire - 4,000 mg, kulawa kwa mandimu - 4,000 mg, sodium saccharase - 5 500 mg, mannitol mpaka 1250 mg.
Mlingo uliwonse wa 5 ml wa kuyimitsidwa kwa 250 mg + 62,5 mg / 5 ml uli ndi:
ntchito: amoxicillin (mu mawonekedwe a trihydrate) mogwirizana ndi yogwira - 250 mg, clavulanic acid (mu mawonekedwe a mchere wa potaziyamu) malinga ndi zomwe zimagwira - 62,5 mg, zokopa: citric acid (anhydrous) - 2.167 mg, sodium citrate (anhydrous) - 8.335 mg, sodium benzoate - 2.085 mg, microcrystalline cellulose ndi sodium carmellose - 28.1 mg, xanthan chingamu - 10,0 mg, colloidal silicon dioxide - 16.667 mg, silicon dioxide - 0,217 g, kulawa kwamtchire wamtchire - 4,000 mg, sodium saccharase - 5 500 mg, mannitol mpaka 1250 mg.
Mlingo uliwonse wa 5 ml wa kuyimitsidwa kwa 125 mg + 31.25 mg / 5 ml uli ndi:
ntchito: amoxicillin (mu mawonekedwe a trihydrate) mogwirizana ndi ntchito - 125 mg, clavulanic acid (munthawi ya mchere wa potaziyamu) malinga ndi zomwe zimagwira - 31.25 mg, zokopa: citric acid (anhydrous) - 2.167 mg, sodium citrate (anhydrous) - 8.335 mg, sodium benzoate - 2.085 mg, microcrystalline cellulose ndi sodium carmellose - 28.1 mg, xanthan chingamu - 10,0 mg, colloidal silicon dioxide - 16.667 mg, silicon dioxide - 0,217 g, kununkhira kwa sitiroberi - 15,000 mg, sodium saccharase - 5 500 mg, mannitol mpaka 1250 mg.

Kufotokozera: ufa: kuyambira oyera mpaka oyera achikasu.
Kuyimitsidwa pafupifupi yoyera ndi yachikaso pakayimidwe payokha.

Mankhwala

Mankhwala
Njira yamachitidwe
Amoxicillin ndi mankhwala osokoneza bongo owoneka bwino omwe ali ndi ntchito yolimbana ndi ma gram ambiri komanso gram alibe tizilombo. Nthawi yomweyo, amoxicillin amatha kuwonongedwa ndi beta-lactamases, chifukwa chake ntchito yokhala ndi amoxicillin sinafikira tizilombo tomwe timatulutsa timadzi tambiri.
Clavulanic acid, beta-lactamase inhibitor yokhudzana ndi penicillin, amatha kuyambitsa mitundu yambiri ya beta-lactamases yomwe imapezeka mu penicillin ndi cephalosporin zosagwira tizilombo. Clavulanic acid ili ndi mphamvu yokwanira yolimbana ndi plasmid beta-lactamases, yomwe nthawi zambiri imayambitsa kukokana kwa bakiteriya, ndipo siigwira ntchito motsutsana ndi mtundu I chromosome beta-lactamases, womwe suletsedwa ndi clavulanic acid.
Kupezeka kwa clavulanic acid pakukonzekera kumateteza amoxicillin kuti asawonongeke ndi ma enzymes - beta-lactamases, omwe amalola kukulitsa mawonekedwe a antibacterial a amoxicillin.
Otsatirawa ndi ntchito yophatikiza ya amoxicillin ndi clavulanic acid mu vitro.

Pharmacokinetics
Zogulitsa
Zosakaniza zogwiritsidwa ntchito za mankhwalawa zimatengedwa mwachangu komanso mokwanira kuchokera m'matumbo am'mimba (GIT) pambuyo pakamwa. Mafuta a yogwira zinthu ali bwino mu vuto la kugwiritsa ntchito mankhwala ndi chakudya.
Pansipa pali mapiritsi a pharmacokinetic a amoxicillin ndi clavulanic acid pambuyo pa makonzedwe a 45 mg / 6.4 mg / kg, omwe amagawidwa pawiri, ndi odwala osakwana zaka 12.

Mtengo wamba wa magawo a pharmacokinetic

Сmax - kuchuluka kwa plasma ndende,

Tmax - nthawi yoti mufikire kuchuluka kwa plasma,
AUC ndi malo omwe amaponderezedwa "nthawi yayitali",
T1 / 2 - theka moyo.

Kupenda
Pafupifupi 10-25% ya koyamba mlingo wa amoxicillin amuchotseredwa ndi impso mu mawonekedwe a metabolite wa penicilloic acid. Clavulanic acid m'thupi la munthu imadwala kwambiri mapangidwe a 2,5-dihydro-4- (2-hydroxyethyl) -5-oxo-1H-pyrrole-3-carboxylic acid ndi 1-amino-4-hydroxy-butan-2-one ndikufotokozedwanso ndi impso, kudzera m'mimba, komanso ndi mpweya wotulutsidwa, ngati mpweya wa kaboni.
Kugawa
Monga kuphatikizira kwa kuphatikizika kwa amoxicillin ndi clavulanic acid, zochizira zozama za amoxicillin ndi clavulanic acid zimapezeka m'misempha yambiri komanso mkati mwazinthu (mu ndulu, khungu la adipose ndi minofu, khungu, adipose ndi minofu yamadzi, bile .
Amoxicillin ndi clavulanic acid ali ndi malire ofooka a mapuloteni a plasma. Kafukufuku wasonyeza kuti pafupifupi 25% ya kuchuluka kwathunthu kwa clavulanic acid ndi 18% ya amoxicillin m'magazi am'magazi amaphatikizika ndi mapuloteni am'magazi.
Kuchuluka kwa magawidwe kumakhala pafupifupi 0.3-0.4 L / kg kwa amoxicillin ndi pafupifupi 0,2 L / kg ya clavulanic acid.
Amoxicillin ndi clavulanic acid samadutsa chotchinga magazi mu maukonde osavulala. Amoxicillin (monga ma penicillin ambiri) amathandizidwa mkaka wa m'mawere.
Zotsatira za clavulanic acid zimapezekanso mkaka wa m'mawere. Kupatula kuthekera kwa kutulutsa chidwi, kutsegula m'mimba, ndi masidi a mucous membrane wamkamwa, palibe zovuta zina za amoxicillin ndi clavulanic acid pa thanzi la makanda oyamwitsa.
Kafukufuku wothandizira kubereka kwanyama akuwonetsa kuti amoxicillin ndi clavulanic acid amawoloka chotchinga. Komabe, palibe zoyipa zilizonse pa mwana wakhanda zomwe zapezeka.
Kuswana
Amoxicillin amachotseredwa makamaka ndi impso, pomwe clavulanic acid kudzera munthawi yonse yaimpso ndi zowonjezera. Pambuyo pakamwa kamodzi kokha kwa 875 mg / 125 mg kapena 500 mg / 125 mg, pafupifupi 60-70% ya amoxicillin ndi 40-65% ya clavulanic acid amachotsedwa osasinthika ndi impso nthawi yayitali 6.
Pafupifupi theka la moyo (T1 / 2) wa amoxicillin / clavulanic acid ndi pafupifupi ola limodzi; kuvomerezeka kwathunthu kumakhala pafupifupi 25 l / h kwa odwala athanzi. M'maphunziro osiyanasiyana, zidapezeka kuti impretion ya amoxicillin ndi impso mkati mwa maola 24 ndi pafupifupi 50-85%, clavulanic acid - 27-60%.
Kuchuluka kwa asidi wa clavulanic kumakhudzidwa nthawi yoyamba ya 2 pambuyo pa ntchito.
Ma pharmacokinetics a amoxicillin / clavulanic acid samatengera umunthu wa wodwalayo.
Odwala ndi mkhutu aimpso ntchito
Chilolezo chonse cha amoxicillin / clavulanic acid chimachepera mogwirizana ndi kuchepa kwa impso. Chilolezo chocheperako chimatchulidwa kuti amoxicillin kuposa clavulanic acid, chifukwa ambiri a amoxicillin amamuchotsa impso. Mlingo wa mankhwala aimpso kulephera kuyenera kusankhidwa chifukwa cha kuchepa kwa kuchuluka kwa amoxicillin kwinaku ndikusintha kwacudiulanic acid.
Odwala omwe ali ndi vuto la chiwindi
Odwala omwe ali ndi vuto la chiwindi, mankhwalawa amagwiritsidwa ntchito mosamala. Ndikofunikira kuyang'anira ntchito ya chiwindi nthawi zonse.
Zonsezi zimachotsedwa ndi hemodialysis komanso zochepa pang'onopang'ono diitosis.

Gwiritsani ntchito pa nthawi yoyembekezera komanso nthawi yoyamwitsa

Kafukufuku wazinyama sanawululire zowopsa za kumwa mankhwalawa panthawi yomwe ali ndi pakati komanso momwe zimakhudzira kukula kwa fetal.
Kafukufuku wina mwa azimayi omwe ali ndi matendawa asanakwane, zimapezeka kuti mankhwala a prophylactic omwe ali ndi amoxicillin / clavulanic acid akhoza kuphatikizidwa ndi chiopsezo chowonjezeka cha necrotizing enterocolitis mu akhanda.
Pa nthawi yoyembekezera komanso mkaka wa m'mawere, mankhwalawa amagwiritsidwa ntchito pokhapokha ngati phindu lomwe limaperekedwa kwa mayi limaposa chiwopsezo cha mwana wosabadwayo ndi mwana.
Amoxicillin ndi clavulanic acid ochepa omwe amalowa mkaka wa m'mawere, chifukwa chake, kumwa mankhwalawa panthawi yoyamwitsa kuyenera kupitilizidwa pokhapokha ngati pali umboni wowonekera bwino.
Mu makanda omwe amalandila yoyamwitsa, kukula kwa chidwi, kutsegula m'mimba, ma micidi a mucous nembanemba amkamwa amatha. Zikatero, kuyamwitsa kuyenera kusiyidwa.

Zotsatira zoyipa

Malinga ndi World Health Organisation (WHO), zoyipa zimayesedwa malinga ndi kuchuluka kwa chitukuko motere: pafupipafupi (> 1/10), pafupipafupi (> 1/100, 1/1000, 1/10000, kuchokera ku ziwalo za hematopoietic ndi lymphatic kachitidwe
osati kawirikawiri: leukopenia wosinthika (kuphatikizapo neutropenia), thrombocytopenia,
kawirikawiri eosinophilia, thrombocytosis, kusintha kwa agranulocytosis, kuchuluka kwa magazi nthawi komanso kuwonjezereka kwa prothrombin nthawi, kuchepa magazi, kuphatikizanso kuchepa kwa magazi kwa hemolytic.
Kuchokera ku chitetezo chamthupi
kawirikawiri angioedema, anaphylactic zimachitika, matupi awo samasamba, matenda ofanana ndi seramu matenda.
Kuchokera ku dongosolo lamanjenje
kawirikawiri: chizungulire, kupweteka mutu,
kawirikawiri kusowa tulo, kukhumudwa, nkhawa, kusintha kwa machitidwe, kusinthika kwa magazi, kukhudzika, kukhudzika kumatha kuchitika ndi odwala omwe ali ndi vuto laimpso, komanso kwa omwe amalandira kuchuluka kwa mankhwalawa.
Kuchokera m'mimba thirakiti
Nthawi zambiri: kulephera kudya, nseru, kusanza, kutsegula m'mimba,
Khansa ya msana imawonedwa kwambiri tikamamwa mitundu yayikulu. Ngati kuphwanya kwam'mimba kumatsimikiziridwa, kumatha kutha ngati mutamwa mankhwalawa koyambirira kwa chakudya.
kawirikawiri: kugaya chakudya
kawirikawiri colitis yokhudzana ndi maantiotic omwe amayamba chifukwa cha maantibayotiki (kuphatikizapo pseudomembranous ndi hemorrhagic colitis), lilime la "tsitsi" lakuda, gastritis, stomatitis.
Mu ana, kusintha kwa mawonekedwe a mawonekedwe a mano enamel sikunachitike kawirikawiri. Kusamalira pakamwa kumathandiza kupewa kubowola kwa enamel ya dzino.
Pa khungu
kawirikawiri: zotupa pakhungu, kuyabwa, urticaria,
osati kawirikawiri: erythema multiforme exudative,
kawirikawiri Stevens-Johnson syndrome, poermal necrolysis yoopsa, dermatitis yovuta kwambiri, imabweretsa pustulosis yayikulu.
Kuchokera kwamikodzo
kawirikawiri crystalluria, interstitial nephritis, hematuria.
Pa mbali ya chiwindi ndi biliary thirakiti
kawirikawiri: kuchuluka kwa alanine aminotransferase (ALT) ndi / kapena aspartate aminotransferase (AST), (chochitika ichi chimawonedwa mwa odwala omwe amalandira beta-lactam antiotic mankhwala, koma kufunika kwachipatala sikudziwika).
Zochitika zoyipa kuchokera ku chiwindi zimawonedwa makamaka mwa abambo ndi odwala okalamba ndipo amatha kuyanjana ndi chithandizo cha nthawi yayitali. Zochitika zoyipa izi sizimawonedwa kawirikawiri mwa ana.
Zizindikiro zomwe zalembedwazo zimakonda kuchitika pakumala kapena atangomaliza kumene chithandizo, komabe nthawi zina mwina sangawonekere kwa milungu ingapo atamaliza kulandira chithandizo. Zochitika zoyipa nthawi zambiri zimasinthidwa.
Zochitika zoyipa za chiwindi zimatha kukhala zowopsa, nthawi zina pamakhala nkhani zakufa. Pafupifupi nthawi zonse, awa anali anthu omwe anali ndi vuto lalitali kapena omwe amamwa nthawi yomweyo mankhwala a hepatotoxic.
kawirikawiri kuchuluka kwa alkaline phosphatase, kuchuluka kwa bilirubin, hepatitis, cholestatic jaundice (wodziwika ndi concomitant mankhwala ndi penicillin ena ndi cephalosporins).
Zina
Nthawi zambiri: candidiasis a pakhungu ndi mucous nembanemba,
maulendo osadziwika: kukula kwa tizilombo tating'onoting'ono.

Kutulutsa Fomu

Mphamvu yakuyimitsidwa pakamwa
Mlingo wa 125 mg + 31.25 mg / 5 ml ndi 250 mg + 62,5 mg / 5 ml:
Ma CD oyambira: 25 g wa ufa (100 ml ya kuyimitsidwa kotsirizika) mugalasi lamdima lamdima ndi chilembo (100 ml). Botolo limatsekedwa ndi screw cap lomwe limapangidwa ndi polyethylene yapamwamba kwambiri yokhala ndi mphete yowongolera komanso ndi chidindo chofiyira mkati mwa kapu kapena chidutswa chachitsulo chachitsulo ndi mphete yolamulira, mkati mwa kapu pali gasket yopangidwa ndi polyethylene otsika.
Katundu wachiwiri:
Botolo imodzi yokhala ndi supuni ya mulingo wokhala ndi ziwonetserozo mkati mwa 2,5 ml ndi 5 ml ("2.5 SS" ndi "5 SS"), chizindikiro chodzaza ndi 6 ml ("6 SS") pa chogwirizira cha supuni ndi malangizo ntchito zachipatala mu katoni.
Botolo imodzi yokhala ndi pipette yomaliza maphunziro ndi malangizo ogwiritsa ntchito kuchipatala pabokosi la makatoni.
Mlingo wa 400 mg + 57 mg / 5 ml:
Ma CD oyambira: 8.75 g (35 ml ya kuyimitsidwa kotsiriza), 12,50 g (50 ml ya kuyimitsidwa kotsiliza), 17.50 g (70 ml ya kuyimitsidwa kotsiriza) kapena 35.0 g (140 ml ya kuyimitsidwa kotsiriza) wa ufa mu botolo lamdima galasi yokhala ndi screw cap yomwe imapangidwa ndi polyethylene yapamwamba kwambiri yokhala ndi mphete yowongolera komanso ndi chidindo cha tapered mkati mwa kapu.
17.50 g (70 ml ya kuyimitsidwa kotsirizika) mu botolo lagalasi lakuda ndi chilembo (70 ml) chokhala ndi screw cap yopangidwa ndi polyethylene wapamwamba kwambiri wokhala ndi mphete yolamulira komanso ndi chidindo chofiyira mkati mwa kapu.
Katundu wachiwiri:
Botolo imodzi yokhala ndi pipette yomaliza maphunziro ndi malangizo ogwiritsa ntchito kuchipatala pabokosi la makatoni.