Ethamsylate: malangizo, ntchito, zikuonetsa,

Ethamsylate ndi he heaticatic wothandizira, wodziwika ndi angioprotective ndi proaggregate kanthu. Mankhwala amafulumizitsa kukula kwa mapulateleti ndi kutuluka kwawo kuchokera kumongo, kumapangitsa kukhazikika kwa makhoma a capillaries, kotero kuti amayamba kulowa. Imatha kuwonjezera kuphatikiza kwa mapulosi ndi kuletsa ma prostaglandin biosynthesis.

Kugwiritsidwa ntchito kwa Etamsylate kumathandizira kupangika kwa thrombus yoyamba ndikuwonjezera kutulutsa kwake, makamaka popanda kukhudza zomwe zili mu fibrinogen m'magazi ndi nthawi ya prothrombin. Mulibe katundu wa hypercoagulant; kugwiritsa ntchito mankhwalawa sakukhudza mapangidwe amitsempha yamagazi.

Ndi mtsempha wa intravenous (iv), kutsegula kwa njira ya hemostasis kumachitika mkati mwa mphindi 5 mpaka jakisoni, ndipo mphamvu yofunikira imatheka pambuyo pa maola 1-2. Kutalika kwa kuchitapo ndi maola 4-6.

Mukamwetsa mapiritsi a Ethamsylate, mphamvu yake imalembedwa pambuyo pa maola 2-4. Mphamvu ya yogwira ntchito m'magazi ndi 0,05-0.02 mg / ml. Mankhwalawa amachotsedwa mu mkodzo (80%), pang'ono ndi bile.

Pambuyo pa mankhwala, achire zotsatira zimatha masiku 5-8, pang'onopang'ono kufooka. Kuchita bwino kwambiri komanso kuchuluka kwakanthawi kotsutsana ndi mankhwalawa kumapereka ndemanga zabwino za Etamsilate ndi madokotala.

Mankhwala sinafotokozeredwe pachimake porphyria, thrombosis ndi mimba.

Fomu ya Mlingo:

Ethamsylate imapezeka ngati yankho la jakisoni wamkati ndi mu mnofu, mapiritsi ndi mapiritsi a ana.

Zisonyezo Ethamsilate

Malinga ndi malangizo ogwiritsira ntchito Etamsylate, mankhwalawa amagwiritsidwa ntchito ngati mankhwala a monotherapy komanso mitundu yovuta ya chithandizo cha:

Kuyimitsa ndi kupewa magazi a capillary poyerekeza ndi matenda a shuga.
Zochita za opaleshoni muzochita za otolaryngological (tonsillectomy, microsurgery ndi zina),
Opaleshoni yamphongo (kuchotsedwa kwapa, keratoplasty, opaleshoni ya antiglaucomatous),
Ntchito zamano (kuchotsedwa kwa granulomas, cysts, dzino kutulutsa mano),
Ntchito zamaubongo (prostatectomy),
Zina, kuphatikiza zakuthwa, kuchitapo kanthu - makamaka ziwalo ndi minyewa yolumikizana kwambiri,
Kusamalira mwadzidzidzi magazi am'mapapu komanso m'mimba,
Hemorrhagic diathesis.

Malangizo a Etamsylate - mapiritsi ndi jakisoni

Jakisoni wa Ethamsilate amawonetsedwa kudzera m'mitsempha ndi intramuscularly, mu mawonekedwe a ophthalmic - mawonekedwe a madontho amaso ndi retrobulbar.

Mlingo wokhazikika wa akulu:

Mkati, muyezo umodzi wa Ethamsilate wa akulu ndi 0,25-0,5 g, monga momwe zikuwonekera, mulingo utha kuwonjezeka mpaka 0.75 g, kholo - 0,125-0.25 g, ngati pangafunike mpaka 0,375 g.

Zochizira - .
Ngati ndi kotheka, jekeseni 2-4 ml ya mankhwalawa mu ntchito.

Pakakhala chiopsezo chotuluka m'magazi a postoperative, 4 mpaka 6 ml (2-4 ampoules) amathandizira patsiku kapena mapiritsi a 6 mpaka 8 a Etamsylate amaperekedwa patsiku. Mlingo amagawidwa wogawana kwa maola 24.

Zadzidzidzi: jekeseni yomweyo / kapena kudzera m'mitsempha, kenako maola 4 ndi theka mkati, mu / m kapena mkati. Kulowetsedwa ndikulimbikitsidwa.

Mankhwalawa metro- ndi menorrhagia, malangizo a ethamzilate wokhudzana ndi msambo akuonetsa kuchuluka kwa 0,5 g pakamwa kapena 0.25 g paubwino (wodutsa mgawo logaya chakudya) pambuyo pa maola 6 kwa masiku 5-10.

Pambuyo pa zolinga zodzitetezera - 0,25 ga pakamwa kanayi tsiku lililonse kapena 0,25 ga muyezo wa makolo kawiri tsiku lililonse pakukha magazi (kutulutsa magazi) ndi maulendo awiri omalizira.

Mu matenda a shuga a myacroangiopathy, jakisoni wa Ethamsylate amathandizidwa ndi mafuta kwa masiku 10-14 mu gawo limodzi la 0.25-0,5 g katatu pa tsiku kapena m'mapiritsi atatu ndi kumwa ndi mapiritsi a 1-2 katatu patsiku.

Ndi hemorrhagic diathesis, mankhwalawa amathandizira kukhazikitsidwa kwa mankhwalawa 1.5 ga patsiku pafupipafupi kwa masiku 5 mpaka 14. Woopsa milandu, mankhwalawa amayamba ndi makonzedwe a parenteral a 0,25-0,5 g 1-2 pa tsiku kwa masiku 3-8, kenaka adalembedwa pakamwa.

Mankhwala a kukanika kwa uterine magazi, Ethamsylate ayenera kumwedwa pakamwa pa 0,6 magalamu aliwonse 6. Kutalika kwa mankhwalawa kuli pafupifupi masiku 10. Ndiye yokonza mlingo wa 0,25 ga ndi zotchulidwa 4 pa tsiku mwachindunji pakukha magazi (ma 2 omaliza). Parenteral 0,25 ga amatumizidwa 2 pa tsiku.

Mu ophthalmology, mankhwalawa amaperekedwa kwa subconjunctival kapena retrobulbar - pa mlingo wa 0.125 g (1 ml ya yankho la 12.5%).

Kwa ana:

Pa ntchito prophylactically, pakamwa Mlingo wa 10-12 mg / kg mu 2 mgulu waukulu kwa masiku 3-5.

Zadzidzidzi pa opaleshoni - jekeseni ya ethamzilate kudzera mu 8-10 mg / kg thupi.

Pambuyo pa opaleshoni, pofuna kupewa magazi - mkati, pa 8 mg / kg.

Ndi hemorrhagic syndrome mu ana, Ethamsylate amamuika limodzi mlingo wa 6-8 mg / kg pamlomo, katatu patsiku. Kutalika kwa mankhwalawa ndi masiku 5 mpaka 14, ngati ndi kotheka, maphunzirowa abwerezedwa pambuyo masiku 7.

Mankhwalawa amagwiritsidwa ntchito mwa ana opitilira zaka 6. Osati mankhwala pamaso pa hemoblastoses.

Choweta Chanyama:

Ethamsylate imagwiritsidwanso ntchito ngati Chowona Zanyama. Mlingo wa amphaka ndi 0.1 ml pa kilogalamu ya kulemera kwa nyama, kawiri pa tsiku (jakisoni).

Contraindication Etamsylate

Contraindication wa mankhwala amagwirizana ndi kuchuluka kwa thrombosis ndi zina zomwe zimayenderana:

Hypersensitivity pamagawo a mankhwala,
Thrombosis, thromboembolism, kuchuluka magazi
Acute mawonekedwe a porphyria,
Hemoblastosis (lymphatic ndi myeloid leukemia, osteosarcoma) mwa ana.

Chenjezo ndi magazi pa maziko a bongo wa anticoagulants.

Mankhwala osagwirizana ndi mankhwala ena. Osasakaniza mu syringe yomweyo ndi mankhwala ena ndi zinthu.

Zotsatira zoyipa Etamzilat

kumva kusasangalala kapena kuwotcha pachifuwa,
kumverera kwa kulemera mu dzenje la m'mimba
mutu ndi chizungulire,
nthambi yamitsempha yamafuta pamaso
kutsika kwa magazi a systolic,
kumverera kosasangalatsa kwa necrosis ya khungu (dzanzi), mapangidwe a "tsekwe zazikulu" kapena zachilendo, zowawa pakukhudza.

Analogs a Etamsilat, mindandanda

Mukafuna kusinthitsa, chonde onani kuti analogue yokhayo yonse ya Etamsilate ndi Dicinon. Zofananira zina pa thupi:

Kusintha kulikonse kwa Etamzilat ndi analogues kuyenera kuvomerezana ndi adokotala! Ndikofunika kumvetsetsa kuti malangizo awa ogwiritsira ntchito mapiritsi a Etamsylate ndi jakisoni sakukhudzanso ma analogues ndipo sayenera kugwiritsidwa ntchito ngati chitsogozo chogwira ntchito popanda kupangana ndi dokotala.

Malo osungira
Sungani pamalo amdima kutali ndi ana pa kutentha kosaposa 25 ° C.

Zotsatira za pharmacological

Hemostatic, angioprotective wothandizira.

Imagwira pambale yolumikizira heestasis. Imalimbikitsa mapangidwe a mapulateleti ndikumasulidwa kwa mapulateleti kuchokera m'mphepete mwa mafupa, imawonjezera kuchuluka kwawo ndi zochita zawo. Imawonjezera kuchuluka kwa mapangidwe oyamba a thrombus, omwe amatha kukhala chifukwa cha kukakamira pang'ono kwa mapangidwe a minofu ya thromboplastin, ndikuwonjezera kubwezera kwa thrombus. Ili ndi antihyaluronidase zochita, imalepheretsa kugawanika kwa mucopolysaccharides khoma lamitsempha ndikukhazikika ascorbic acid, chifukwa chomwe kukana kwa capillaries kumawonjezeka, kuchuluka kwake ndi kufooka kwa ma cellvessels kumachepa. Ilibe mphamvu ya hypercoagulant, sichikhudzanso kuchuluka kwa nthawi ya fibrinogen ndi prothrombin.

Kuchuluka kwakukulu mukamamwa pakumveka pambuyo pa maola atatu. Muli kuchuluka kwa mlingo wa 1-10 mg / kg, kuopsa kwa zochita kumakhala kofanana ndi mlingo, kuwonjezereka kwa mlingo kumabweretsa kungowonjezera pang'ono pakuchita bwino. Pambuyo pa chithandizo, zotsatira zake zimapitilira kwa masiku 5-8, pang'onopang'ono zikuchepa.

Pharmacokinetics

Pambuyo pakukonzekera pakamwa, imatha kutengeka kwathunthu kuchokera kumimba. Kuphatikiza kwakukulu m'magazi kumatheka pambuyo pa maola 3-4. Kuthamanga kwamitsempha yamagazi m'magazi ndi 0.05-0.02 mg / ml. Amangokhala wofowoka kumapuloteni ndi ma cell amagazi. Imagawidwanso chimodzimodzi ziwalo zosiyanasiyana ndi minyewa (kutengera kuchuluka kwa magazi awo). Pafupifupi 72% ya mlingo wothandizidwa umachotsedwa pakatha maola 24 ndi mkodzo osasinthika. Ethamsylate amadutsa chotchinga kulowa mkaka wa m'mawere.

Zizindikiro zogwiritsidwa ntchito

Kupewa ndikuwongolera kwamatumbo mumtundu wapamwamba komanso wamkati wamitundu yosiyanasiyana, makamaka ngati magazi amatuluka chifukwa cha kuwonongeka kwa endothelial:

- kupewa ndi kuchiza magazi munthawi ya opareshoni ya otolaryngology, gynecology, obstetrics, urology, mano, ophthalmology ndi opaleshoni ya pulasitiki,

- kupewa ndi kuchiza magazi a m'magazi osiyanasiyana a ziwonetsero zosiyanasiyana: hematuria, metrorrhagia, hypermenorrhea yayikulu, hypermenorrhea mwa amayi omwe ali ndi intrauterine contraceplication, nosebleeds, gum magazi.

Mlingo ndi makonzedwe

Kugwiritsidwa ntchito mkati mosasamala chakudya.

Panthawi yopangira opaleshoni, achikulire amalembedwa 0,5-0.75 g (mapiritsi a 2-3) maola atatu asanachitidwe opareshoni, ana opitirira zaka 12 amawonetsedwa pamlingo wa 1-12 mg / kg thupi (1 / 2-2 mapiritsi) tsiku Mlingo wa 1-2, mkati mwa masiku 3-5 musanachite opareshoni.

Ngati pali vuto loti magazi atha kugwira ntchito, akulu amapatsidwa 1-2 g (mapiritsi a 4-8), ana opitirira zaka 12 ndi omwe amapatsidwa kulemera kwa thupi kwa 8 mg / kg (mapiritsi 1-2) motsatana (mu Mlingo wa 2-4) tsiku loyamba pambuyo machitidwe.

Pankhani ya hemorrhagic diathesis (thrombocytopathy, matenda a Villeurbrand, matenda a Wörlhoff), akulu amamuika maphunziro a 1.5 g (mapiritsi 6), ana opitirira zaka 12 amaikidwa 6,5 mg / kg thupi patsiku katatu pamagawo atatu ogawika mosiyanasiyana nthawi ya masiku 5 mpaka 14. Njira ya chithandizo, ngati ndi kotheka, imatha kubwerezedwa pambuyo masiku 7.

Mu matenda a diabetesicangiangiopathies (ma retinopathies omwe amatupa), akuluakulu amawerengera mapiritsi a 0,25-0,5 g (mapiritsi 1-2) katatu patsiku kwa miyezi 2-3, ana opitirira zaka 12 - 0,25 g (piritsi 1) ) Katatu patsiku kwa miyezi iwiri.

Mankhwalawa metro ndi menorrhagia, 0,75-1 g (mapiritsi 3-4) amalembedwa tsiku lililonse mu 2-3 Mlingo, kuyambira tsiku la 5 la msambo woyembekezeredwa mpaka tsiku la 5 la msambo wotsatira. Palibe umboni wa kufunika kosintha mtundu wa anthu omwe ali ndi vuto la chiwindi ndi impso.