Malangizo ogwiritsira ntchito mankhwala a Telsartan ndikuwunika za nkhaniyi

Zonse Zokhudza Matenda A shuga ”Momwe mungagwiritsire ntchito Telsartan 40?

Chiwerengero cha mankhwala omwe amachepetsa kuthamanga kwa magazi ndikuwakhalitsa pamlingo woyenera kwambiri akuphatikiza Telsartan 40 mg. Ubwino wa mankhwalawa: kumwa piritsi 1 patsiku, nthawi yayitali ya antihypertensive kwenikweni, osakhudza kugunda kwa mtima. Zizindikiro za systolic ndi diastolic kuthamanga kwa magazi momwe angathere pambuyo pa mwezi wokhawo wogwiritsa ntchito mankhwalawa.

• 8.10 kuchokera ku chiwindi ndi biliary thirakiti
• 8.11 Matumbo
• 8.12 Zothandiza pa kuthekera koyendetsa makina

Kutulutsa mafomu ndi kapangidwe kake

Mankhwalawa ndi piritsi yoyera yoyera yopanda chipolopolo, convex mbali zonse ziwiri. Pamwambapa aliyense wa iwo ali ndi zoopsa zosweka ndi zilembo "T", "L", m'munsi - chiwerengero "40". Mkati, mutha kuwona zigawo ziwiri: chimodzi ndichipi cha mitundu yosiyanasiyana, china chimakhala choyera, nthawi zina chimakhala ndi timalingaliro tating'ono.

Mu piritsi 1 la mankhwala osakanikirana - 40 mg ya kaphatikizidwe kamene kamapezeka ndi telmisartan ndi 12,5 mg wa hydrochlorothiazide diuretic.

Zinthu zothandiza zimagwiritsidwanso ntchito:

• mannitol
• lactose (shuga mkaka),
• povidone
• meglumine
• magnesium wakuba,
• sodium hydroxide
• polysorbate 80,
• utoto E172.

Mu piritsi 1 la mankhwala osakanikirana - 40 mg ya kaphatikizidwe kamene kamapezeka ndi telmisartan ndi 12,5 mg wa hydrochlorothiazide diuretic.

Mapiritsi a 6, 7 kapena 10 ma PC. kuyikidwa mu matuza okhala ndi zojambula za aluminium zojambulazo ndi filimu ya polima. Atanyamula makatoni 2, 3 kapena 4 matuza.

Zotsatira za pharmacological

Mankhwala amatulutsa wapawiri zochizira: hypotensive ndi okodzetsa. Popeza kapangidwe kazinthu kamene kamapanga kantchito kameneka kamafanana ndi kapangidwe ka mtundu wa 2 angiotensin, telmisartan imachotsa timadzi tomwe timalumikizana ndi zotengera zamagazi ndipo imaletsa ntchitoyo kwanthawi yayitali.

Nthawi yomweyo, kupanga aldosterone yaulere imalephereka, yomwe imachotsa potaziyamu m'thupi ndi kukhalabe ndi sodium, zomwe zimapangitsa kuwonjezeka kwa kamvekedwe ka mtima. Nthawi yomweyo, ntchito ya renin, enzyme yomwe imayendetsa kuthamanga kwa magazi, siyikakamizidwa. Zotsatira zake, kukwera kwa kuthamanga kwa magazi kumayima, kuchepa kwake kwakukulu kumachitika pang'onopang'ono.

Pambuyo maola 1.5-2 mutamwa mankhwalawa, hydrochlorothiazide imayamba kupereka mphamvu zake. Kutalika kwa nthawi ya diuretic kumasiyana kwa maola 6 mpaka 12. Nthawi yomweyo, kuchuluka kwa magazi ozungulira kumachepa, kupanga aldosterone kumawonjezereka, ntchito ya renin imakulanso.

Kuphatikizika kwa telmisartan ndi diuretic kumatulutsa antihypertensive kwambiri kuposa momwe zimagwirira aliyense payekhapayekha. Pa mankhwala ndi mankhwalawa, mawonetseredwe a myocardial hypertrophy amachepetsa, amafa amachepetsa, makamaka odwala okalamba omwe ali ndi chiwopsezo chachikulu cha mtima.

Pa mankhwala ndi mankhwalawa, mawonekedwe a myocardial hypertrophy amachepetsedwa.

Kuphatikiza kwa telmisartan ndi hydrochlorothiazide sikumasintha ma pharmacokinetics a zinthu. Awo wonse bioavailability ndi 40-60%. Zigawo zogwira ntchito za mankhwalawa zimatengedwa mwachangu kuchokera kugaya chakudya. Kuchuluka kwa telmisartan kudzikundikira m'madzi am'magazi pambuyo pa maola 1-1,5 ndi kutsika kwa 2-3 kwa amuna kuposa akazi. Kutenga pang'ono kwa mthupi kumachitika m'chiwindi, umatulutsidwa m'zimbudzi. Hydrochlorothiazide imachotsedwa m'thupi pafupifupi osasinthika ndi mkodzo.

Zizindikiro zogwiritsidwa ntchito

• mankhwalawa matenda oyamba ndi owopsa ochepa, pamene chithandizo chokhala ndi telmisartan kapena hydrochlorothiazide chokha sichimapereka zotsatira zomwe mukufuna,
• popewa zovuta zamatenda amtima kwambiri mwa anthu azaka zopitilira 55-60,
• popewa zovuta zomwe zili ndi odwala omwe ali ndi matenda amtundu wa II (osagwirizana ndi insulin) omwe amawonongeka chifukwa cha matenda oyambitsidwa ndi matendawa.

Contraindication

Zifukwa zoletsa kulandira chithandizo ndi Telsartan:

• Hypersensitivity kwa yogwira mankhwala
• matenda oopsa a impso
• kutenga Aliskiren mwa odwala ndi aimpso kulephera, matenda ashuga,
• chiwindi kulephera,
• bile duct chotchinga,
• kufupika kwa lactase, tsankho lactose,
• hypercalcemia,
• hypokalemia
• mimba ndi mkaka wa m`mawere
• ana ochepera zaka 18.

Chenjezo liyenera kuchitika ngati matenda otsatirawa kapena matenda atapezeka mwa odwala:

• kutsika kwa magazi,
• stenosis ya mitsempha ya impso, mavavu amtima,
• kulephera kwamtima kwambiri
• kulephera kwachiwindi,
• matenda ashuga
• gout
• adrenal cortical adenoma,
• kutseka-kotsekera glaucoma,
• lupus erythematosus.

Momwe mungatenge Telsartan 40

Mlingo wambiri: pakamwa tsiku lililonse musanadye komanso paphwando, piritsi limodzi, lomwe liyenera kutsukidwa ndi madzi pang'ono. Mulingo wambiri watsiku ndi tsiku wa mitundu yayikulu ya matenda oopsa mpaka 160 mg. Kuyenera kukumbukiridwa: njira zoyenera zochiritsira sizimachitika mwachangu, koma pambuyo pa miyezi 1-2 yogwiritsa ntchito mankhwalawa.

Mlingo wambiri: pakamwa tsiku lililonse musanadye komanso paphwando, piritsi limodzi, lomwe liyenera kutsukidwa ndi madzi pang'ono.

Odwala omwe ali ndi matendawa nthawi zambiri amaperekedwa kuti aletse zovuta pamtima, impso ndi maso. Kwa odwala matenda ashuga ambiri omwe ali ndi matenda oopsa, kuphatikiza kwa Telsartan ndi Amlodipine kukuwonetsedwa. Nthawi zina, kuchuluka kwa uric acid m'magazi kumakwera, gout ikukula. Pangakhale kofunikira kusintha mlingo wa mankhwala a hypoglycemic.

Zotsatira zoyipa za Telsartan 40

Ziwerengero zosagwirizana ndi mankhwalawa komanso telmisartan zotengedwa popanda hydrochlorothiazide ali ofanana. Pafupipafupi pamavuto ambiri, mwachitsanzo, kusokonezeka kwa minofu trophism, metabolism (hypokalemia, hyponatremia, hyperuricemia), sikugwirizana ndi kuchuluka, jenda komanso zaka za odwala.

Mankhwala osowa nthawi zina angayambitse:

• kamwa yowuma
• dyspepsia
• chisangalalo
• kupweteka m'mimba
• kudzimbidwa
• kutsegula m'mimba
• kusanza
• gastritis.

Zokhudzana ndi mankhwalawa zingaphatikizeponso:

• kutsika kwa hemoglobin,
• kuchepa magazi
• eosinophilia
• thrombocytopenia.

A pafupipafupi zotsatira chizungulire. Sizichitika kawirikawiri:

• paresthesia (zomverera zam'madzi zotuluka, kumva kulira, ululu woyaka),
• kugona, kapena, kugona.
• mawonekedwe osaneneka
• nkhawa
• kukhumudwa
• syncope (kufooka mwadzidzidzi), kukomoka.

• kuchuluka kwa uric acid, creatinine m'madzi am'magazi,
• ntchito yayikulu ya enzyme CPK (creatine phosphokinase),
• pachimake aimpso kulephera
• matenda a kwamkodzo thirakiti, kuphatikizapo cystitis.

Zotsatira zoyipa:

• kupweteka pachifuwa
• kupuma movutikira
• matenda ngati chimfine, sinusitis, pharyngitis, chifuwa,
• chibayo, edema yam'mapapo.

• erythema (kufiira pakhungu),
• kutupa
• zotupa
• kuyabwa
• thukuta kwambiri
• urticaria
• dermatitis
• chikanga
• angioedema (osowa kwambiri).

Telsartan sikuti imawononga ntchito ya maliseche.

• ochepa kapena orthostatic hypotension,
• brady, tachycardia.

Zotsatira zotsatirazi za musculoskeletal system ndizotheka:

• kupindika, kupweteka m'misempha, tendon, mafupa,
• kukokana, nthawi zambiri m'miyendo,
• lumbalgia (kupweteka kwapweteka kumbuyo.

Mothandizidwa ndi mankhwalawa nthawi zina, zotsatirazi zingaoneke:

• zachiwindi mu chiwindi,
• kuchuluka kwa michere yopangidwa ndi thupi.

Kugwedeza kwa anaphylactic ndikosowa kwambiri.

Popeza chiwopsezo cha kugona, chizungulire sichingalephereke, kusamala kumalangizidwa poyendetsa galimoto, kugwira ntchito yofunika chidwi kwambiri.

Malangizo apadera

Ndi kuchepa kwa sodium mu plasma kapena kuchuluka kosakwanira kozungulira magazi, kuyambitsidwa kwa mankhwala osokoneza bongo kumatha kutsagana ndi kuchepa kwa kuthamanga kwa magazi. Acute hypotension nthawi zambiri amakumana ndi odwala aimpso stenosis, matenda a mtima, komanso kulephera kwamtima. Kugwa kovuta kwa kupsinjika kumatha kubweretsa stroko kapena myocardial infaration.

Gwiritsani ntchito mankhwalawa mosamala komanso stenosis ya mitral kapena aortic valve.

Mwa odwala matenda ashuga, matenda a hypoglycemia amatha. Ndikofunikira kuyang'ana kuchuluka kwa shuga m'magazi, kusintha magawo a othandizira a hypoglycemic.

Mwa odwala matenda ashuga, matenda a hypoglycemia amatha.

Hydrochlorothiazide monga gawo la Telsartan imatha kuwonjezera kuchuluka kwa nayitrogeni mankhwala osakanikirana aimpso, komanso imapangitsa kukula kwa pachimake myopia, khungu-kutsekeka kwa glaucoma.

Kugwiritsa ntchito mankhwalawa kwa nthawi yayitali nthawi zambiri kumayambitsa hyperkalemia. Pangakhale kofunikira kuti muwunikire zomwe zili ma elekitirodi mu madzi am'magazi.

Kuchepetsa kwakumwa kwa mankhwalawa sikupangitsa kuti achoke.

Ndi chachikulu hyperaldosteronism, achire zotsatira za Telsartan palibe.

Mankhwala osokoneza bongo amatsutsana panthawi ya gestation ndi yoyamwitsa.

Mankhwalawa sanapangidwe kuti azigwiritsidwa ntchito ndi odwala ochepera zaka 18.

Palibe matenda ophatikizika kwambiri, palibe chifukwa chosinthira mlingo.

Kusintha kwa mankhwalawa sikofunikira kwa odwala omwe ali ndi vuto la impso mosiyanasiyana, kuphatikiza zikuchitika hemodialysis njira.

Malinga ndi zotsatira za maphunziro ambiri mwa odwala omwe ali ndi vuto la chiwindi chochepa, mlingo wa mankhwalawa sikuyenera kupitirira 40 mg.

Malinga ndi zotsatira za maphunziro ambiri mwa odwala omwe ali ndi vuto la chiwindi chochepa, mlingo wa mankhwalawa sikuyenera kupitirira 40 mg.

Kuchita ndi mankhwala ena

Kugwiritsa ntchito pamodzi ndi mankhwala ena omwe amachepetsa kuthamanga kwa magazi, mankhwalawa amawonjezera mphamvu zawo zochizira.

Mukatenga Telsartan ndi Digoxin, kuchuluka kwa mtima glycoside kumawonjezeka kwambiri, chifukwa chake kuyang'anira kuchuluka kwake kwa seramu ndikofunikira.

Pofuna kupewa hyperkalemia, mankhwalawa sayenera kuphatikizidwa ndi othandizira omwe ali ndi potaziyamu.

Kuyang'anira kuyang'anira kuchuluka kwa lifiyamu m'magazi uku mukugwiritsa ntchito mankhwala okhala ndi zitsulo zamafuta alkali, chifukwa telmisartan imawonjezera kawopsedwe awo.

Glucocorticosteroids, Aspirin ndi mankhwala ena osapweteka a antiidal omwe amachepetsa mphamvu ya antihypertensive.

NSAIDs limodzi ndi telmisartan imatha kufooketsa impso.

Mukamamwa mankhwala, simuyenera kumwa mowa wamtundu uliwonse.

Telsartan ikhoza m'malo mwa mankhwalawa ndi zotsatira zomwezi:

Ndemanga pa Telsartan 40

Maria, wazaka 47, Vologda

Mapiritsi akulu ndipo akuwoneka kuti ndiye otetezeka kwambiri pazithandizo zambiri zamatenda a mtima. Ndizodabwitsa kuti mankhwalawa amapangidwa ku India, osati ku Germany kapena Switzerland. Zotsatira zoyipa ndizochepa. Nthawi zina chiwindi chimangondivuta, koma zandipweteka kwa nthawi yayitali pomwe sindinatengepo Telsartan.

Vyachedlav, wazaka 58, Smolensk

Ndili ndi matenda oopsa kwa nthawi yayitali. Kuphatikiza kulephera kwambiri kwaimpso. Kukonzekera kokha komwe sikunayenera kulandira kwa zaka zambiri! Koma nthawi zina zimayenera kusinthidwa, chifukwa thupi limazolowera, kenako zimasiya kuchita ngati kale. Ndakhala ndikutenga Telsartan posachedwapa. Malangizo ake amapereka mndandanda wazotsatira zoyipa, koma palibe amene adakumana nawo. Mankhwala abwino omwe amakhala ndi mavuto. Choonadi ndichokwera mtengo.

Irina, wazaka 52, Yekaterinburg

Kwa nthawi yoyamba, katswiriyu adati Amlodipine ayenera kumwedwa, koma patatha sabata limodzi miyendo yake idayamba kutupa. Adotolo adalowa m'malo mwake ndi Enap - posakhalitsa kudwala kudayamba kundisokoneza. Kenako ndinasinthira ku Telsartan, koma zinafika poti ndinali ndi vuto lililonse ndi iye. Panali mseru, kenako zotupa pakhungu linatuluka. Apanso ndinapita kuchipatala. Ndipo pokhapokha akatswiri odziwa Concor atachita zonse zidachitika. Ndilibe vuto ndi mapiritsi awa. Chifukwa chake ndikofunikira kwambiri kuti adokotala akusankhirani mankhwala oyenera.

Zambiri pazamankhwala

Zochita za mankhwalawa zimaphatikizapo osati kutsitsa magazi, komanso kuchepetsa nkhawa pamtima, chitetezo cha ziwalo zozungulira (retina, mtima endothelium, myocardium, bongo, impso), makamaka ndi kukhalapo kwa zowonjezera zowopsa (kuchuluka kwamitsempha yamagazi, shuga mellitus).

Telsartan imachepetsa kukana kwa insulini, imawonjezera kugwiritsa ntchito shuga, kukonza dyslipidemia (imachepetsa kuchuluka kwa LDL "yoyipa" ndikuwonjezera "yothandiza" HDL).

Gulu lazachipatala, INN, kuchuluka

Telsartan ndi angiotensin-II receptor blocker (AT1) yosankha. Telsartan N - wa mankhwala osakanikirana, amaphatikiza chipika cha angiotensin-II receptors (AT1) ndi chophatikizira chachikulu komanso mphamvu yotsutsana ndi hydrochlorothiazide. Mwa kapangidwe ka mankhwala, ndimtundu wa biphenyl netetrazole mankhwala. Ndi mankhwala ogwirira ntchito. Wotsutsana wopanda mpikisano yemwe amangirira kwa receptors mosasinthika.

Zotsatira za angiotensin II receptor antagonists

INN: Telmisartan / Telmisartan. Amagwiritsidwa ntchito mu mtima polimbana ndi kuchuluka kwa systolic ndi diastolic, kulephera kwa mtima. Telsartan N imagwiritsidwa ntchito posagwiritsa ntchito monotherapy ndi mankhwala a magulu ena.

Mitundu ya kumasulidwa ndi mitengo ya mankhwala, avareji ku Russia

Mankhwala amapangidwa mawonekedwe a piritsi, mu awiri Mlingo - 40 ndi 80 mg. M'bokosi lamatoni 3 matuza a mapiritsi 10. Mapiritsiwo ali ndi mawonekedwe owongoka, onyansa mbali zonse, popanda chipolopolo, choyera ngati chipale, ndi mzere pakati mbali imodzi, mbali zake zomwe pali zokutira ziwiri - "T ndi L", mulingo umasonyezedwa mbali yakumbuyo.

Gome ili pansipa likuwonetsa mtengo muma ruble a mankhwala:

Gome limawonetsa zigawo zikuluzikulu za mankhwalawa:

Pharmacodynamics ndi pharmacokinetics

Telsartan ndi mtundu wosankha 1 angiotensin-II receptor inhibitor. Ma receptor awa amapezeka mu minofu yambiri ya thupi, makamaka minofu yosalala ya ziwiya, myocardium, cortical wosanjikiza tamadontho, mapapu, ndi mbali zina za ubongo. Angiotensin-II ndiye chinthu champhamvu kwambiri chotulutsa peptide chomwe ndi renin-angiotensin-aldosterone system (RAAS).

Kudzera pama receptors amtunduwu, zotsatirazi zimazindikira kuti mwachindunji kapena m'njira zina zimathandizira kuti magazi azithamanga, koma osakhalitsa. Zochita za Telsartan cholinga chake ndikuchepetsa, mwachitsanzo, zimatsekedwa kapena kupewa:

• onjezani kwathunthu kukana kwa mitsempha yosiyanasiyana,
• vasoconstriction yamitsempha yama glomeruli impso ndi kuwonjezeka kwa hydraulic anzawo;
• kusungidwa kwamadzi ambiri: kuyamwa kwa sodium ndi madzi mu proximal tubules, kupanga aldosterone,
• kumasulidwa kwa antidiuretic mahomoni, endothelin-1, renin,
• kutsegula kwa mtima wachifundo-adrenal dongosolo ndi kumasulidwa kwa makatekolamaini chifukwa cholowera kudzera mu chotchinga cha magazi,

Kuphatikiza pa RAAS ya kawonedwe, palinso machitidwe amtundu wa (RA) wa RAA mumisempha ndi ziwalo zosiyanasiyana. Kutulutsa kwawo kumayambitsa zotsatira zazitali za angiotensin, zomwe zimabweretsa kuchuluka kwa endothelium ndi minofu yosanjikiza yamagazi, mtima wamtima, kukonzanso kwa myocardial, myofibrosis, kuwonongeka kwa mitsempha ya mitsempha, nephropathy, ndi kuwonongeka kwa ziwalo.

Chizindikiro cha Telsartan ndikuti chimasankha kokha mtundu woyamba wa angiotensin-II receptors kwa nthawi yayitali ndikuchotsa kwathunthu zoyipa za angiotensin, kungoti "osaloleza" kupita ku receptors.

Kuchitikaku kumatenga maola 24 mpaka 48. Kuchepa kwa kuthamanga kwa magazi kumachitika bwino, pang'onopang'ono kwa maola angapo. Poyerekeza ndi ACE omwewo zoletsa, omwe akuti ndi gulu limodzi labwino kwambiri la mankhwala othandizira, njira zotsatirazi ndi mwayi wowonekera wa mankhwalawa:

• blockade yathunthu yazotsatira zoyipa za angiotensin (zoletsa za ACE sizinatsekeredwe),
• kuzindikira zabwino za angiotensin kudzera ma receptors a mtundu wa AT2 (ACE zoletsa, m'malo mwake, muchepetse),
• sichimaletsa kinase, chifukwa chomwe sichikhala ndi vuto la bradykinin ndipo, chifukwa chake, zoyipa zomwe zimakhudzana ndi izi (chifuwa, angioedema, zotsatira za sumu, kuchuluka kwa prostacyclin),
• organoprotection.

Zilandira zamtundu wachiwiri siziphunziridwa bwino, koma asayansi adatha kuzindikira kuti alipo ambiri mu nthawi ya embryonic, yomwe ingawonetse kusintha kwawo maselo komanso kusasitsa. Pambuyo pake, kuchuluka kwawo kumachepa. Zomwe amachita kudzera pama receptor awa ndi zosemphana ndi zochita za ma receptor oyamba. Zotsatira zabwino kudzera pa AS2 receptors ndi izi:

• kukonza minofu pa ma cellular,
• vasodilation, kuchuluka kwa NO-factor,
• kuletsa kukula kwa maselo, kuchuluka,
• kuletsa kwa mtima hypertrophy.

Telsartan H ali ndi mphamvu yopitilira muyeso ya antihypertensive, yomwe imakhala ndi hydrochlorothiazide - diopathy yodutsa yomwe imachepetsa kubwezeretsanso kwa sodium ion ndi madzi ndi impso, ndikupereka mphamvu yotsutsa. Imaperekanso mwayi wogwiritsa ntchito: mmalo mwa mapiritsi angapo, ndikokwanira kumwa kamodzi pa maola 24, omwe akupereka zotsatira zabwino.

Ndi kupitiriza ntchito, achire zotsatira za telmisartan amapezeka pafupifupi 3-5-7 milungu. Momwemonso amachepetsa kupanikizika kwa systolic ndi diastolic. Palibe vuto lochotsa: mukasiya kumwa mankhwalawo, kupanikizika kumabwereranso ku manambala ambiri kwa masiku angapo, palibe kulumpha lakuthwa mukasiya.

Mukamamwa pachilichonse, kuchuluka kwambiri m'magazi kumachitika pambuyo pa maola 1-2. Bioavailability ndi 60%, imalowa mwachangu. Mankhwalawa amatha kumwa nthawi iliyonse, mosasamala kanthu za zakudya. 98.6% kapena kupitirira kwa mapuloteni a plasma, kuwonjezera pamenepo kumangiriza minofu (gawo logawa pafupifupi 510 l).

Kuchuluka kwa magazi a azimayi ndiwokwera kuposa kwa abambo, izi sizikhudza kuthandizira. Pafupifupi 98% ya telmisartan imachotsedwa kudzera mu biliary system, yaying'ono - ndi mkodzo. Zimapangidwa ndi conjugation, zomwe zimapangitsa kupanga acetylglucoronide mu mawonekedwe osagwira. Chilolezo chonse ndicoposa 1499 ml / min. Kutha kwa theka-moyo wopitilira maola 19. Hydrochlorothiazide samapangidwira ndipo amamuchotsa ndi mkodzo mwaulere.

Pharmacokinetics sasintha kutengera jenda ndi zaka. Odwala omwe ali ndi vuto la mayendedwe a msambo, kuchuluka kwa magazi m'magazi kumakhala kochulukirapo kuposa masiku onse, ndi hemodialysis, m'malo mwake, kutsika, ngakhale kuti chinthucho chikugwirika bwino ndi mapuloteni amwazi. Mu vuto la chiwopsezo chiwindi, bioavailability ukuwonjezeka mpaka 98%.

Zizindikiro ndi contraindication

Zizindikiro zazikulu zogwiritsa ntchito Telsartan:

• kuthamanga kwa magazi
• kupewa mtima ndi mtima matenda.
• Kuwonongeka kwa kuwonongeka kwa CVD kwa odwala omwe ali ndi mtundu wa shuga wachiwiri ndi kuwonongeka kwa ziwalo zomwe akutsata,
• kwambiri mtima atherosulinosis.

• matupi awo sagwirizana ndi mankhwala
• 2nd and 3 trimesters of mimba, yoyamwitsa,
• zaka zazing'ono
• kusokoneza kwa machitidwe a biliary,
• kuwonongeka kwambiri kwa chiwindi,
• Hypokalemia komanso hypercalcemia,
• gout
• munthawi yomweyo kugwiritsa ntchito Aliskiren mu shuga.

Chifukwa cha kafukufuku wosakwanira, mankhwalawa sayenera kuperekedwa kwa ana osakwana zaka 18. Ndi zoletsedwa kumwa mankhwalawa nthawi yomwe mayi ali ndi pakati, makamaka mu 2nd ndi 3 trimester, popeza mankhwalawa ali ndi mphamvu kwambiri ya fetoto: kuchepa kwa magwiridwe antchito am'kati, kuchepa pang'onopang'ono, ndi oligohydramnios.

Mwa makanda, pali: kuchuluka kwa potaziyamu, kutsika kwa kukakamiza, kusakwanira kwa dongosolo lamafuku. Sartan iyenera kuyimitsidwa ndikusinthidwa ndi gulu lina la mankhwala. Onetsetsani kuti mukuyang'anira mwana wosabadwayo ndi amayi ake.

Malangizo ogwiritsira ntchito

Mankhwalawa amatengedwa kamodzi pa maola 24 aliwonse nthawi yomweyo, osasamala chakudyacho. Imwani zamadzi zambiri. Malinga ndi malangizo ogwiritsira ntchito Telsartan, mlingo woyambirira ndi 20 mg, ndiye kuti mlingowo ungachulukane pang'onopang'ono. Mlingo wa 40 mg nthawi zambiri umagwira. Mwa odwala "omwe akupitiliza", mutha kuwonjezera kuchuluka kwa 80 mg patsiku, koma osapitilira. Mlingo wake ndiwambiri.

Ngati njira ina yolephera monotherapy, kuphatikiza kwa angiotensin receptor blockers ndi diuretic kumagwiritsidwa ntchito, mankhwala a Telsartan N.

Sitikulimbikitsidwa kuphatikiza kutenga Telsartan ndi potaziyamu kukonzekera, ACE inhibitors, saltingtics ya potaziyamu, NSAIDs, Heparin, immunosuppressants - chifukwa izi zimatha kupangitsa kuchuluka kwa ayoni a potaziyamu m'thupi. Kugwiritsira ntchito koyanjana ndi kukonzekera kwa lithiamu sikulimbikitsidwanso, chifukwa izi zimatha kuyambitsa kawopsedwe ake.

Odwala oopsa kwambiri nthawi zambiri amadandaula ngati Telsartan ndi Diuver atha kutengedwa nthawi yomweyo. Kafukufuku wasonyeza kuti kugwiritsa ntchito telmisartan ndi torasemide, ndizomwe zimagwira kwambiri pazinthu izi, zimabweretsa kuchepa kwakukulu kwa magazi.

Gwiritsani ntchito kuphatikiza uku mosamala, chifukwa kutulutsa madzi kwambiri kumatha kubweretsa Hypotension. Musanagwiritse ntchito mankhwala aliwonse, komanso kuphatikiza kwawo, muyenera kufunsa dokotala.

Zotheka zoyipa ndi bongo

Mankhwala osokoneza bongo amatha kuopseza zotsatirazi:

• hypotension
• tachycardia
• Zizindikiro zam'maso
• kulephera kwa aimpso.

Mankhwalawa ali ndi mndandanda wazovuta zake zoyipa, komanso zomwe ndizochepa:

• syncope,
• arrhythmia, tachycardia,
• chizungulire
• vertigo
• parasthesia
• dyspeptic phenomena.

M'malo mwa mankhwala Telsartan:

• Mikardis.
• Telzap
• Telmista.
• Telpres.
• Wotsogolera.
• Tanidol.
• Izi.
• Hipotel.

Kusiyanitsa kofunikira pakati pa mankhwalawa ndi mtengo, dziko lomwe mwachokera mulinso losiyana, lomwe limakhudza mtundu wa kuyeretsa kwa zigawo za mankhwala. Mwa katundu, mankhwalawa ndi ofanana. Koma mawonekedwe ofunikira kwambiri ndi Mikardis, Praitor ndi Telpres.

Ndemanga za madotolo ndi odwala

Mwambiri, onse akatswiri ndi odwala adapereka ndemanga zambiri zabwino za mankhwalawa, nayi ena a iwo:

Alexander Dmitrievich, katswiri wa zamtima: “Mankhwalawa anachepetsa kwambiri anzawo. Zotsatira zake zimakhala nthawi yayitali.

A mawonekedwe ndi mwayi wowonekera bwino ndizovuta zake zosankha zovuta za angiotensin pomwe akukhalabe ndi chiyembekezo. Zokwanira kumwa piritsi limodzi patsiku. Ndikosavuta kusankha ndikusintha mlingo. Mankhwala a m'badwo waposachedwa kwambiri.

Kutengera ndi chidziwitso chodziwika bwino cha mankhwalawa, titha kunena motsimikiza kuti lero ndi amodzi mwa mankhwala othandiza kwambiri antihypertensive. Mwakusankha amachotsera zotsalazo ndikukhala ndi chothandiza pa mtima ndi thupi lonse.

Dzinalo Lopanda Padziko Lonse

Mankhwala a INN - Telmisartan.

Pazigawo zapadziko lonse lapansi za ATX, mankhwalawo ali ndi code C09CA07.

Kugwiritsidwa ntchito kwa Telsartan kukuwonetsedwa pamikhalidwe yambiri yamatenda, limodzi ndi kuwonjezeka kwa kuthamanga kwa magazi.

Pharmacokinetics

Mukamamwa mankhwalawo, chinthu chake chogwira ntchito chimayamba kugwira. Bioavailability ukufika 50%. Kuchuluka kwa mankhwala omwe ali m'magazi mwa amuna ndi akazi kumakwaniritsidwa patatha maola atatu atayikidwa. Mankhwalawa amamangidwa ndi mapuloteni a plasma. Mankhwala kagayidwe amapezeka ndi nawo glucuronic acid. Ma metabolabol amamuchotsa ndowe mkati mwa maola 20.

Ndi chisamaliro

Chithandizo cha telsartan chimafuna kusamala kwambiri mu aimpso. Kuphatikiza apo, odwala omwe ali ndi mitral ndi aortic valve stenosis panthawi ya mankhwala a Telsartan amafunikira chisamaliro chapadera kuchokera kwa akatswiri azachipatala. Chisamaliro chapadera chikuyenera kutengedwa ndi hypokalemia ndi hyponatremia. Ndizotheka kugwiritsa ntchito pokhapokha moyang'aniridwa ndi madokotala ndipo ngati pali wodwala yemwe ali ndi mbiri yokhudza kupatsirana kwa impso.

Ndi matenda ashuga

Kwa odwala omwe ali ndi matenda a shuga a mtundu wachiwiri, mankhwalawa adapangidwa muyezo wa 20 mg. M'tsogolomu, mlingo wa tsiku ndi tsiku ukhoza kuwonjezeka mpaka 40 mg.

Kudya sizikhudzana ndi mayamwa a yogwira mankhwala.

Kuchokera ku genitourinary system

Odwala ena amakhala ndi cystitis. Nthawi zina, pang'onopang'ono chifukwa cha matenda oopsa a genitourinary system, sepsis imatha kuchitika.

Odwala ena amakhala ndi cystitis.

Pa mbali ya chiwindi ndi biliary thirakiti

Ndizachilendo kwambiri pochiza Telsartan kuti pali kuphwanya kwa chiwindi ndi njira yothandizira.

Ndi osowa kwambiri pochiza Telsartan kuti pali kuphwanya chiwindi.

Ngati wodwalayo ali ndi hypersensitivity, thupi lawo siligwirizana, limatchulidwa ngati zotupa pakhungu komanso kuyabwa, komanso edema ya Quincke.

Gwiritsani ntchito pa nthawi yoyembekezera komanso mkaka wa m`mawere

Chithandizo cha Telsartan cha amayi mu trimesters onse am'mimba sichiri chovomerezeka. Sikulimbikitsidwa kugwiritsa ntchito mankhwalawa poyamwitsa.

Chithandizo cha Telsartan cha amayi mu trimesters onse am'mimba sichiri chovomerezeka.

Kugwiritsa ntchito kwa vuto la chiwindi

Mankhwalawa sangathe kugwiritsidwa ntchito pochiza anthu omwe ali ndi matenda a chiwindi, limodzi ndi kutsekeka kwa machitidwe a biliary ndi cholestasis.

Mankhwalawa sangathe kugwiritsidwa ntchito pochiza anthu omwe ali ndi matenda a chiwindi, limodzi ndi kutsekeka kwa machitidwe a biliary ndi cholestasis.

Kuyenderana ndi mowa

Muyenera kukana kumwa mowa panthawi ya Telsartan.

Muyenera kukana kumwa mowa panthawi ya Telsartan.

Masinthidwe a Telsartan omwe ali ndi zofanana ndi achire zotsatira amaphatikizapo: