Mankhwala Metformin-Canon wochizira matenda ashuga

Kunenepa kwambiri komanso kuchuluka kwamafuta sikuwongoleredwa. Sikuti nthawi zonse pamakhala vuto la munthu ndi zizolowezi zake, chifukwa kumwa mankhwala ena kumapangitsa kuti munthu akhale wonenepa. Ndizosatheka kuthana ndi zotsatira za chithandizo popanda mankhwala, zomwe zimabweretsa kuikidwa kwa Metformin Canon wa mankhwala othandizira odwala matenda a shuga. Umu ndi mtundu wa piritsi wa mankhwala a hypoglycemic.

Chochita chozikidwa pa metformin chimapangidwa, motero pogulitsa mungapeze mayina osiyanasiyana ogulitsa mankhwalawa: Glucofage, Metformin Richter (Teva) kapena Siofor. Cholinga chachikulu ndikuchiza matenda a shuga, koma tsopano amagwiritsidwa ntchito kuthana ndi kunenepa kwambiri komanso kunenepa kwambiri kwamitundu yosiyanasiyana.

Kufotokozera ndi kapangidwe

Metformin Canon ndi wa m'badwo wachitatu wa Biguanides. Amagwiritsidwa ntchito pochiza matenda a shuga pobwezeretsa mulingo wa lipid ndikuwongolera kulemera kwa munthu.

Chachilendo cha mankhwalawa, chomwe chimasiyanitsa bwino ndi analogues, ndiko kusowa kwa njira yowonjezera yolimbitsa pancreatic. Metformin imasintha shuga m'magazi.

Mankhwala amaphatikizidwa ndi monga:

Talc,
Primogel
Macrogol
Titanium ndi talc dioxide,
Povidone
Opadry yoyera.

Mankhwalawa amagulitsidwa mwa mawonekedwe a mapiritsi ozungulira kapena ozungulira omwe ali ndi bulge pang'ono, omwe amabisika ndi chipolopolo choyera. Njira zosankha zimasiyana. Chifukwa chake, mapiritsi a 500 mg atha kugulidwa m'chigawo cha ma ruble 160 kwa mayunitsi 60, ndipo dzina la malonda Metformin Canon ndi Mlingo womwe uli wokwanira 2 kuposa woyamba uja - ma ruble 138 (ma 30 ma PC.). Ndipo mitundu yachitatuyo imawululidwa mu kuchuluka kwa mapiritsi 30 a ruble 90, ngati mlingo wa yogwira ndi 850 mg.

Kulimbikitsa njira yamatenda a glucose opangidwa ndi minofu yamatenda,
Matenda a anaerobic kagayidwe ka shuga m'matumbo,
Mafuta a cholesterol athunthu amachepa,
Mafuta a asidi mumafuta a chiwindi
The lipid zikuchokera magazi bwino,
Mafuta ndi kugwiritsa ntchito shuga mwa madipoziti amafuta,
Kutsitsa magazi
Kuwonongeka kwa glycogen m'chiwindi.

Onetsetsani kuti mukuwerenga: Kuuluka kumeza - tiyi wazitsamba kuti muchepetse kunenepa

Kuchuluka kwa shuga m'magazi kumatsika, zomwe zimapangitsa kuti mayendedwe a mayamwidwe ndi matumbo ake. Zotsatira zake, imagwiritsidwa ntchito ndi minofu ina ndikusinthidwa kukhala mphamvu yofunikira mthupi, osati mafuta oyikamo.

Mankhwalawa ali ndi ntchito yofunikira komanso yofunika - imayambitsa kuchepa thupi, ndipo ichi ndi chizindikiro chabwino cha chiwongolero cholondola cha glycemia mwa odwala omwe ali ndi matenda a shuga a 2.

Zizindikiro ndi contraindication

Wothandizira hypoglycemic pamankhwala amagwiritsidwa ntchito ngati mankhwala ochepetsa shuga. Mofananamo, chinthu chogwira ntchito chimakhala ndi kutuluka kokwanira pazinthu zina ndi machitidwe. Koma panthawi yomwe nthumwi zina za gulu lino la anthu odwala matenda ashuga sizilamulira kuchuluka kwa shuga osalamulirika, Metformin Canon salola kuti gawo lagwera pansi pazoyenera.

Zina zothandiza pakumwa mankhwalawa:

Anachepetsa chilako
Kuchulukitsa chidwi kwa olandirira insulin -
Kuchepa kwa shuga panthawi yomwe munthu sanadyebe chifukwa cha kuchepa kwa kuchuluka kwa glycogen m'chiwindi.
Matenda a magazi cholesterol,
Kuchepetsa mapangidwe a glycogen kuchokera ku mapuloteni ndi mafuta,
M'matumbo, kuyamwa kwa zakudya zamafuta kumachepetsedwa kwambiri.

Mukamamwa mankhwalawa, pali njira yabwino yochepetsera mafuta am'mimba pamimba, zomwe zimatengera kuzindikira kwa ma receptors kuti apange insulin. Pali maphunziro omwe asayansi ndi akatswiri azakudya ku England adakhazikitsa kudalira kwa moyo wamtsogolo pogwiritsira ntchito mankhwalawa.

Anthu ambiri onenepa kwambiri amasankha mankhwalawa kuti akonze zolemetsa chifukwa kuchepa kwa mtima wofuna chakudya. Koma mankhwalawa Metformin Canon ali ndi vuto limodzi - limakhudza momwe wodwalayo amagwirira ntchito. Pogwiritsa ntchito maphunzirowa, zimakhala zovuta kwambiri kuti munthu athe kudutsa mndandanda womwewo wa masewera olimbitsa thupi, chifukwa chake madokotala amalimbikitsa pakuthandizira mankhwala kuti achepetse nthawi yayitali komanso kuchuluka kwamakalasi.

Mankhwala Metformin Canon amawonetsedwa kuti azitsatira izi: matenda a shuga mwa odwala azaka 10 komanso kuzindikira komweko kwa akuluakulu. Njira ya mankhwala ikuchitika onse mu mawonekedwe osakanikirana ndi ma hypoglycemic piritsi akukonzekera, komanso ngati mankhwala okha.

Onetsetsani kuti mukuwerenga: Kirimu ya French Vichy yogwira mtima ya matanda otambasuka

Contraindra wa mankhwala chidwi:

Amimba
Kuperewera kwa mtima, mapapu, impso,
Odwala oyamwitsa
Matenda a chiwindi ndi am'mimba
Type 1 and Type 2 shuga.

Matenda ndi zotupa, komanso zovuta zina zilizonse, zimakhala cholepheretsa kumwa mapiritsi awa. Kuledzera ndikutsatira pafupipafupi pazakudya zovuta komanso zopatsa mphamvu kumabweretsa kuti kuthetsedwe kwa njira yochiritsira.

Simungagwiritse ntchito mankhwalawa odwala omwe ali ndi vuto la kupuma mu mawonekedwe osakhazikika. Pambuyo poyambitsa myocardial, munthu amaletsedwa kumwa mankhwalawa Metformin Canon panthawi yochira, komanso pakukonzanso pambuyo pakuchita opaleshoni kapena kuvulala kwambiri.

Mlingo ndi makonzedwe

Madongosolo onsewa adzafotokozeredwa ndi adotolo atapimidwa mozama ndikuganizira momwe thanzi la wodwalayo lilili. Ndi zoletsedwa kuti musamadziyerekeze ndikumapereka kapena kusintha magawo ake komanso kuchuluka kwake. Mapiritsi amatengedwa pokhapokha kapena nthawi ya chakudya, osati kutafuna kapena kuluma, koma kumeza. M`pofunika kumwa ndi madzi voliyumu 250 ml.

Mlingo woyambirira ndi 1000 mg, koma simuyenera kumwa nthawi 1. Wodwala ayenera kugawa piritsi zingapo. Madokotala amalongosola izi mwa njira yomwe ingapangitse kupweteka kwa thupi la munthu kuchitidwe cha chinthu - metformin. Kumayambiriro kwa maphunzirowa, odwala amatha kuwona zotsatira zoyipa, chifukwa chake, kupewa ngozi yosasangalatsa, kudya kwa tsiku ndi tsiku kuyenera kugawidwa m'magawo ang'onoang'ono angapo.

Ngati pali ma pathologies am'mimba otayidwa mu kusanza, kutsekula m'mimba, kapena zilonda zam'mimba, simuyenera kusiya maphunziro ena apambuyo. Akatswiri komanso wopanga mankhwalawa akutsimikizira kuchepa kwa zizindikiro pambuyo pa masabata awiri ovomerezeka.

M'masiku otsatirawa, pamene zochita zoyambirira pazogwira ntchito zimatsalira, adokotala adzakulitsa mlingo mpaka 2000 mg patsiku. Ndikofunika kukumbukira kuti mapiritsi atatu a 1000 mg patsiku sayenera kumwa. Odwala achichepere kuyambira zaka 10 amaloledwa kumwa Metformin-Canon ndi mlingo wa 500 mg patsiku. Mwayi wotenga mapiritsi amadzulo uyenera kulemekezedwa. Pambuyo pa masabata awiri, voliyumu imachulukitsidwa katatu, ndipo malire okwanira ndi mapiritsi awiri a 1000 mg kapena mapiritsi 4 a 500 mg patsiku.

Onetsetsani kuti mukuwerenga: Kumwa mankhwala a Doppelherz kuti muchepetse thupi komanso kuchira kwamatenda a metabolic

Madokotala ndi wopanga amawonetsa zoyenera zapadera kwa okalamba. Kutalika kwa nthawi ya maphunzirowa komanso kumwa kwa mankhwalawa kungathe kutsimikiziridwa ndi kupezeka kwa dokotala pambuyo pakuwunika ndi kusonkhanitsa mayeso. Koma odwala omwe ali ndi zaka 60 atamwa mapilitsi amatha kudandaula kuti vuto la impso.

Zochita Zosiyanasiyana

Zotsatira za Metformin Canon sizosangalatsa kwambiri, koma mukungoyenera kupulumuka zizindikiro izi. Zina mwazodziwika bwino ndi izi:

Hypovitaminosis B12,
Kusanza ndi kusanza
Kutsekula m'mimba ndi kumatulutsa, mpweya,
Ululu pamimba
Kuperewera kwathunthu kwamatenda,
Hypoglycemia,
Megaloblastic anemia,
Thupi lawo siligwirizana.

M'mayendedwe a pathological omwe amayamba chifukwa cha kuperewera kwa m'mimba, wodwalayo sayenera kuchita chilichonse, popeza zizindikiro zimadutsa pakatha milungu iwiri. Nthawi zina, muyenera kusiya kumwa mapiritsi ndi kufunsa dokotala.

Pankhani ya bongo ndi piritsi, wodwalayo anapezeka ndi lactic acidosis. Izi zimadziwika ndi zizindikiro zotsatirazi:

Kutentha kochepa
Kuperewera kwa mgwirizano
Kutaya chikumbumtima
Coma
Mitundu ya mayendedwe amatumbo ikusintha,
Zowawa mu epigastric dera,
Kutulutsa minofu
Kupuma pang'ono.

Pamaso pa kusintha kwakukuru kwa zamankhwala komwe kumafuna kuyitanidwa mwachangu kwa gulu lachipatala ndi kuchipatala, kugwiritsa ntchito mankhwalawa Metformin Canon kuyimitsidwa. Kuchotsa zotsalira za chinthu chogwira ntchito kuchipatala, hemodialysis ndi mankhwala.

Mankhwala moyenera amasunga shuga pamlingo woyenera, pomwe akukhudza mafuta m'thupi. Chokhacho chomwe chimasokoneza odwala ndizosasangalatsa zoyipa zomwe zimafunika kulekeredwa kwa masiku 10 kapena kuposerapo.

Mlingo wa Ma Fomu ndi Kuchuluka kwa Metformin Canon

Kampani yopanga mankhwala ku Canonfarm Production imapanga mankhwala mu mawonekedwe a mapiritsi ozungulira kapena oval convex mu chipolopolo choyera. Kutengera ndi zomwe zidapezeka ndi metformin hydrochloride, mankhwala omwe ali ndi Mlingo wa 1000, 850, 500 mg angagulidwe mu gulu la mankhwala.

Pa Metformin Canon, mtengo wake udzatengera njira yogulitsira ya mankhwala ndi mlingo:

30 ma PC 850 mg aliyense. - 88-90 rubles.,
30 ma PC 1000 mg iliyonse - ma ruble a 108-138.,
Ma PC 60. 500 mg - ruble 146-160.,
Ma PC 60. 850 mg aliyense - 167-192 ma ruble.,
Ma PC 60. 1000 mg iliyonse - 248-272 rubles.

Kuphatikiza pazomwe zimagwira, mawonekedwe a mankhwalawo amakhalanso ndi zina zowonjezera mu mawonekedwe a wowuma, primogel, povidone, sodium stearyl fumarate, talc. Chipolopolochi chimapangidwa ndi oyera opadra II, macrogol, mowa wa polyvinyl, titanium dioxide ndi talc.

Moyo wa alumali wa mapiritsi ndi zaka 2, mankhwalawa safuna mikhalidwe yapadera kuti asungidwe.

Pharmacology

Metformin Canon ndi mankhwala ochepetsa shuga pamlomo, woimira yekha pagulu la Biguanide. Ndi kuchuluka kwa shuga m'magazi, kumachepetsa mulingo wake, kulepheretsa glucogenesis m'chiwindi, kutseka mayamwidwe ake m'matumbo a matumbo, ndikuwonjezera mwayi wake wogwiritsidwa ntchito ndi minofu, komwe imasinthidwa kukhala mphamvu, m'malo mwa mafuta, chifukwa chakuwonjezeka kwa chidwi cha maselo a cell cell kulowa insulin.

Kuchepetsa kwa insulin kukokana kwambiri ndi minofu yolimba, mafutawo amakhala ovuta kupukusa metabolite.

Metformin imalimbikitsa glycogen synthase ndi ma cell glycogeneis. Mosiyana ndi kukonzekera kwa gulu la urea la sulfanyl, kupanga insulin sikulimbikitsa biagunids. Izi sizimabweretsa chiwopsezo chowonjezereka cha kapamba ndi ma b-cell, sizimayambitsa zochitika za hypoglycemic mwa anthu athanzi omwe amagwiritsa ntchito metformin kuti achepetse thupi, kupewa oncology ndi zochitika zamtima, kapena kutalikitsa moyo atakula (pambuyo pa 40).

Chofunikira pakuwongolera kwathunthu kwa matenda amtundu wa 2 matenda a shuga ndicholimbitsa thupi. Mosiyana ndi mankhwala ambiri a hypoglycemic, Metformin Canon satenga mbali ina iliyonse poyerekeza ndi kunenepa, ndipo kugwiritsa ntchito nthawi zonse kumathandizanso kuti muchepetse kuchepa.

Pharmacokinetics

Kuyamwa kwa metformin m'makoma am'mimba kumatengera kudzazidwa kwake: ngati mumamwa mapiritsi musanadye, mayamwidwe ndi 48-52%, mukamagwiritsa ntchito mankhwalawa nthawi yomweyo monga chakudya, njirayo imachepetsa ndipo ntchito yake imachepa.

Chiwonetsero chachikulu cha biagunide (2 μg / l) chimawonedwa pambuyo pa maola awiri ndi atatu. Thupi limafalikira mwachangu kudzera mu minofu, ndi mwamtheradi bioavailability wa 60%. Ma metabolite samakumana ndi mapuloteni am magazi, koma amalowa m'magazi ofiira a m'magazi. Ambiri mwa mankhwalawa amadziunjikira impso, chiwindi, ma gasi a salivary. Mukamagwiritsa ntchito piritsi lolemera 850 mg, voliyumu yogawa idzakhala 296-1012 malita.

Metformin metabolites m'thupi sanapezeke, impso zimachotsa mu mawonekedwe osasinthika. Mwa anthu omwe ali ndi metabolism yachilendo, chilolezo cha metformin chilipo 400 ml / min. Kutha kwa theka-moyo ndi maola 6.2. Ndi a impso pathologies, chizindikiro ichi chimawonjezeka, ndipo ndi chiopsezo cha kukopeka kwa metformin, kupangitsa lactic acidosis.

Zisonyezo zakusankhidwa kwa Metformin Canon

Metformin Canon imaperekedwa kwa odwala matenda ashuga omwe ali ndi matenda amtundu wa 2 ngati kusintha kwasinthidwe (zakudya zama carb otsika, masewera olimbitsa thupi, chiwonetsero chazomvera) sanaperekenso chiwongolero chonse cha glycemic.

Kwa odwala onenepa kwambiri, metformin ndiye chisankho chabwino kwambiri. Mankhwalawa amaphatikizidwa bwino ndi mankhwala a hypoglycemic a magulu ena a ma pharmacological, momwe mawotchi amachitidwe amasiyana ndi biguanides. Mwina chithandizo chokwanira ndi insulin.

Mankhwala amasonyezedwanso zochizira matenda amishuga amtundu wa 2 kwa ana okulirapo zaka 10. Amagwiritsidwa ntchito ngati mankhwala a mzere woyamba kapena kuphatikiza ndi insulin.

Omanga a thupi amagwiritsa ntchito mankhwalawa pouma minofu, kuyesa kuchepa thupi komanso atsikana, koma kugwiritsa ntchito mankhwalawa kumakhala koyenera pokhapokha ngati vuto la kunenepa kwambiri limalumikizidwa ndi insulin kukaniza ndi zovuta zama metabolic.

WHO imalimbikitsa metformin kwa odwala athanzi atatha zaka 40 ali ndi 200 mg / m / tsiku. kutalikitsa moyo (kupewa atherosulinosis, zochitika zamtima, oncology).

Akuluakulu odwala matenda ashuga

Mankhwalawa amagwiritsidwa ntchito ngati mankhwala a monotherapy kapena osokoneza bongo. Mlingo woyambira wa Metformin Canon, malinga ndi malangizo ogwiritsira ntchito, ndi 1000-1500 mg / tsiku. Ngati mumagawanitsa masiku onse kawiri kawiri, mutha kuchepetsa zomwe zimachitika mu vuto la dyspeptic. Pambuyo pa masabata awiri, ngati thupi lasintha, koma glucometer sakulimbikitsa, kusinthitsa pang'ono pang'onopang'ono kwa Mlingo ndikotheka.

Posintha ma analogi ena, wina akuyenera kuwongoleredwa ndi kuchuluka kwa mankhwala apambuyo, komanso nthawi yomwe amachotseredwa (njira yotalikilapo imafunikira kupuma pang'ono).

Ngati Metformin Canon amathandizira odwala matenda ashuga kuphatikiza jakisoni wa insulini, kuyamba kwa mapiritsi sikudutsa gawo limodzi patsiku la mlingo wa 1000 mg, katatu kapena tsiku. pa mlingo wa 500-850 mg. Poterepa, kuchuluka kwa insulini kumatchulidwa molingana ndi mawonekedwe a menyu komanso zofunikira za glucometer.

Odwala odwala

Matenda a shuga a mtundu 2 kwa ana siachilendo masiku ano, makamaka m'maiko otukuka. Zakudya zabwino, kusachita masewera olimbitsa thupi, kupsinjika kwakukulu kumapangitsa zinthu kufalikira kwa ana. Metformin Canon amalembera ana azaka zopitilira 10 ngati mankhwala a mzere woyamba kapena kuphatikiza jakisoni wa insulin.

Mlingo woyambira, malangizo amalimbikitsa kusankha osachepera - 500 mg / tsiku. Piritsi imaperekedwa kwa mwana madzulo, panthawi yachakudya chokwanira. M'masabata awiri, mutha kuwunika momwe mankhwalawo amathandizira ndikusintha mlingo, pang'onopang'ono mungamubweretse pazokonzanso (1000-1500 mg / tsiku) kapena pazokwanira (200 mg / tsiku). Mlingo wa tsiku ndi tsiku umagawidwa mu Mlingo wa 2-3.

Odwala a Msinkhu Wokhwima

Kwa zaka zambiri, odwala matenda ashuga omwe akudziwa zambiri (osati zokhazokha), mphamvu ya impso imachepa, motero Metformin Canon amalembedwa kuti awone mwadongosolo ntchito zawo miyezi isanu ndi umodzi iliyonse. Kutalika kwa maphunzirowa kukhazikitsidwa ndi adotolo, ndikofunikira kuti azitha kuyendetsa mankhwalawa pakumwa mankhwala amgulu lino la odwala ashuga komanso osasokoneza chithandizo popanda chilolezo cha endocrinologist.

Malangizo owonjezera

Kuchiza ndi Metformin Canon kumafuna kuyang'anitsitsa glucometer tsiku ndi tsiku ndikujambulitsa zotsatira mu diabetes. Kuphatikiza pa kusala shuga, ndikofunikira kuyang'anitsitsa ndikumatha, patatha maola awiri mutatha kudya. Ngati zotsatira zake zikupitilira zomwe zapita ndi 3mmol / l, muyenera kusintha kadyedwe.

Mukamapereka mankhwala, odwala matenda ashuga amuchenjezedwa za zotsatira zosayembekezereka: ngati musanza komanso kusanza, kupweteka kwam'mimba, minyewa yam'mimba komanso kuchepa mphamvu kwa mphamvu, muyenera kusiya kugwiritsa ntchito mankhwalawo ndikuwuza adotolo.

Mavuto ocheperako a dyspeptic (chopondapo ndi vuto lakudya) amachoka popanda chithandizo chamankhwala, koma zizindikilo zina zimakhala ma foni oyamba opanga lactic acidosis.

Metformin, monga mankhwala ena amkamwa a hypoglycemic, amathetsedwa masiku awiri asanachitike opareshoni, mayeso a x-ray (kuphatikiza anti-imaging, iv urography), omwe amagwiritsa ntchito ma iodine-based radiopaque markers. Panthawi imeneyi, wodwalayo amasamutsidwa ku insulin. Malangizo am'mbuyomu amabwezedwa patatha masiku awiri atatha njira zake, ngati mkhalidwe wake sufuna njira zina.

Metformin imachotsedwa ndi impso, motero, isanayambike maphunzirowa komanso nthawi yomwe mukumwa mankhwalawa, kuyimitsidwa kwa creatinine kuyenera kuwunikidwa: ndi thanzi labwinobwino la impso - nthawi 1 pachaka, kuchepetsedwa kwa KK komanso kukula - 2-4 nthawi / chaka.

Zizindikiro za matenda am'mapapo, bronchi, ndi urogenital sphere ziyeneranso kukhala chifukwa chochezera endocrinologist.

Poyerekeza ndi chithandizo cha metformin, mowa ndi woopsa kwambiri. Kuletsa ntchito za chiwindi, kupanga amkati glycogen, kumaopseza kukula kwa hypoglycemic ndi disulfiram-like.

Mafuta osakwanira a vitamini B 12 amakwiya chifukwa choletsa mayamwidwe ake. Vutoli limachitika chifukwa chomwa mankhwala nthawi yayitali ndipo chimasinthidwanso. Ngati zizindikiro za hypovitaminosis B12 zimawonedwa, metformin iyenera kusintha ndi analogues.

Kukopa pa kuthekera kolamulira zida zovuta

Metformin Canon sikukhudzana ndi kasamalidwe ka kayendedwe kapena kayendedwe kazovuta ngati imagwiritsidwa ntchito mu monotherapy. Ndi zovuta mankhwala a sulfonylureas ndi insulin, zotsatira za hypoglycemic ndizotheka, zomwe zimapangitsa kwambiri psychomotor zimachitikira komanso ndende.

Zotsatira zoyipa

Metformin ndi mankhwala okhala ndi umboni wamphamvu wodalirika komanso wowoneka bwino, muyezo wa golide pothana ndi matenda a shuga, koma mankhwalawa amadziwika ndi anthu osiyanasiyana odwala matenda ashuga. Zotsatira zoyipa kwambiri zomwe zimachitika ndi dyspeptic, munthawi yakusintha, ochepa omwe amatha kupewa. Ngati mumwa mapiritsi ndi chakudya, ndikuwonjezera mlingo wake, mutha kuchepetsa zomwe zikupezeka m'mimba.

Choyipa china ndi lactic acidosis, yomwe imayamba ndi kudzikundikira kwa metformin mthupi logwirizana ndi kulephera kwa impso. Milandu yotereyi ndiyosowa kwambiri, yolosera ndipo imafuna kusiya mankhwala. Ndikosavuta kuwunika kuchuluka kwa zotsatira zoyipa kuchokera ku ziwalo zosiyanasiyana ndi kachitidwe patebulo.

Organs ndi kachitidwe

Mitundu ya zoyipa

CNSkusintha kukoma (kukoma kwachitsulo)nthawi zambiri Matumbokutaya mtima, vuto la kusowa kwa magazinthawi zambiri Machitidwe a heepatobiliarykukanika kwa chiwindi, chiwindimowirikiza Matupi omalizaerythema, zotupa pakhungu ndi kuyabwa, urticariasikawirikawiri Njira zachikhalidwelactic acidosiskawirikawiri Zosankha zinaHypovitaminosis B12, kuchepa kwa mayankho a folic acid, kuchemera magazi m'thupikawirikawiri

Zotsatira zonse zimasinthidwa ndikusowa pambuyo pakuchotsedwa kwa Metformin Canon. Zochita zamankhwala zimawonetsa kuti pa zaka 10-16 zaka zachilengedwe ndi zomwe zimakhala zovuta zimafanana ndi zomwe zimachitika mwa akulu.

Kuphatikiza kophatikizidwa

Omwe amasiyana ndi radiology potengera ayodini, wogwiritsidwa ntchito m'maphunziro a radiology, amatha kupweteka lactic acidosis pamene akutenga metformin. Chifukwa chake, masiku awiri njira zisanachitike komanso masiku awiri atatha kuyesedwa, mapiritsiwo amasinthidwa ndi jakisoni wa insulin.

Zosankha Zothandiza

Mukamagwiritsa ntchito danazol ndi metformin, mikhalidwe ya hypoglycemic ndiyotheka. Ngati ndi kotheka, kuphatikiza koteroko ndikofunikira kumveketsa mlingo wa metformin.

Mlingo wofunika wa chlorpromazine umalepheretsa maselo a insulin, kukulitsa shuga. Ma antipsychotic amafunikiranso kukhathamiritsa mlingo wa metformin panthawi yomweyo ndikutsatira.

Glucocorticosteroids amachepetsa kulolera kwa glucose, pomwe kukulitsa kuchuluka kwake mu plasma, ketosis ndiyotheka kwambiri. Ndi kukhazikitsidwa kwa ziwembu zotere, kuchuluka kwa metformin kumachepetsedwa.

NSAIDs ndi loop diuretics yokhala ndi metformin imayambitsa zovuta za impso. Matendawa ndi owopsa pakukula kwa lactic acidosis.

Nifedipine imathandizira mayamwidwe ndi kuchuluka kwa metformin, mfundoyi iyenera kukumbukiridwa mukamakonzanso njira yothandizira.

Kupititsa patsogolo mphamvu ya hypoglycemic ya mankhwalawa komanso kuphatikiza ndi acarbose, insulin, mankhwala a sulfonylurea.

Mankhwala omwe amagwiritsidwa ntchito pofuna kuthana ndi matenda oopsa amatha kupititsa patsogolo hypoglycemic ndipo amafunikira titration ya mlingo wa metformin.

Contraindication

Kuphatikiza pa hypersensitivity pazosakaniza za formula, mankhwalawa sanaikidwe:

Ndi matenda ashuga, pachimodzimodzi, ketoacidosis,
Kwa odwala matenda ashuga omwe ali ndi CK pansi pa 60 ml / min.,
Amakhudzidwa ndi zovuta kwambiri (kusowa kwamadzi, kutentha thupi, matenda oopsa),
Ndi hypoxia yomwe imayambitsidwa ndi mantha, sepsis, pathologies a impso zamagulu opatsirana, bronchi, mapapu,
Odwala omwe ali ndi pachimake kapena matenda opatsitsa minofu hypoxia,
Kwa nthawi yopangira opaleshoni, mankhwalawa akavulala kwambiri ndikuwotchedwa,
Oledzera osatha, anthu omwe amamwa kwambiri mowa,
Ndi vuto la chiwindi,
Muli lactic acidosis,
Ana osakwana zaka 10, amayi apakati ndi oyamwitsa,
Pakanthawi: ziletso pa nthawi ya ntchito ndi maphunziro a radiology.

Mitundu ya bongo

M'maphunziro azachipatala odzipereka omwe adatenga mapiritsi khumi a metformin (85 g), hypoglycemia sanatchule, adawonetsa zizindikiro za lactic acidosis.

Mutha kuzindikira vutoli chifukwa cha vuto la kusowa kwa magazi, kusintha kwa matumbo, matenthedwe pocheperapo, minofu kukokana ndi kupweteka kwa epigastric, kupuma movutikira, kulumikizana bwino komanso kudziwa, kukomoka komanso kupweteka. Vutoli limafunikira kuchotsedwa kwachangu kwa mankhwala ndi zipatala. Zotsalira za lactate ndi metformin kuchipatala zimathandizidwa ndi hemodialysis.

Kufufuza kwa Mankhwala Osokoneza bongo

About Metformin Canon, ndemanga zimakhala zabwino. Ambiri amadziwa kupezeka kwa mankhwalawa pagawo la mitengo yamagetsi. Theka la odwala amawonetsa shuga wokhazikika, kuwonda, kusamva kudya.

Mwa zina zowunikira, madandaulo azotsatira zoyipa zomwe zimapangitsa kuti pakhale nthawi yayitali. Mwachidziwikire, muzochitika zoterezi, ndikofunikira kukambirana ndi dokotala wanu, chifukwa ngakhale ma fanog ofotokoza metformin ali ndi zinthu zingapo zothandizira zomwe zingayambitse ziwengo ndi zina. Ndikotheka kusintha generic ndi Glucophage yoyambayo.

Mitu ya mankhwalawa

Kwa Metformin Canon, mitundu ingapo ya mankhwala imatha kukhala fanizo. Mankhwala ofanana ndi mankhwala omwewo ndi ofunikira a metformin ndi awa:

Glucophage - mankhwala oyamba achi French omwe ali ndi ma ruble 130.,
Metfogamma - mapiritsi achijeremani pamtengo wokwera ma ruble 330.,
Formetin ndi generic wamba, amagulitsa ma ruble 250.,
Sofamet ndi mawu ofanana ndi Chibugariya, angagulidwe ma ruble 109.

Malinga ndi gulu la ATX, mndandandawo ungathe kuphatikizidwa ndi Siofor, Bagomet, Avandamet, Metformin Teva ndi ma analogu ena. Opanga Metformin Canon amakhalanso ndi zosintha zina nthawi yayitali. Mankhwala omasulidwa pang'onopang'ono akupezeka mu mankhwala a 500, 750 ndi 1000 mg. Choyambirira "chachitali" ndikukhala ndi zofananira zina

Msika wamakono wamankhwala uli ndi mankhwala odana ndi matenda ashuga, koma m'magulu 10 a mankhwala omwe amapangidwira kuthana ndi matenda amtundu wa 2 shuga, metformin yokha imakhalabe yopanda vuto. Ili ndiye mankhwala okhazikika, ophunziridwa bwino omwe odwala matenda ashuga amafunikira pa gawo lililonse la matenda.

Zambiri zosangalatsa za metformin zitha kupezeka mu kanemayo.