Biosulin® P (Biosulin R)

Biosulin P ndi mankhwala osokoneza bongo a insulin. Insulin iyi imapezeka ndi ma genetic engineering, chifukwa chake, malinga ndi gulu, Biosulin P ndi m'gulu la anthu omwe amapanga majini okhala ndi majini.

Kukhazikika kwa chochitika kumachitika pambuyo pa mphindi 30-60 ndipo kumawonedwa kwa maola 6-8.

Ma insulin receptors amapezeka m'thupi lonse chifukwa amaphatikizidwa pafupifupi zochita zonse za metabolic ndipo amachititsa kuchuluka kwakukulu kwa ma intracellular reaction. Koma ziwalo zazikulu za insulin ndi chiwindi, minofu ndi minofu ya adipose. Zachilengedwe zotsatira za insulin:

• Malangizo a kagayidwe kazakudya chifukwa cha kuchuluka kwa mayendedwe ndi kugwiritsa ntchito shuga m'magazi, chifukwa chomwe chiwindi cha glycogen chimapangidwa.
• kuletsa kwa kaphatikizidwe ka shuga mkati chifukwa cha kuponderezedwa kwa kuwonongeka kwa chiwindi ndi glycogen komanso kuchepetsa kupangika kwa shuga kuchokera kumagwero ena.
• kutenga nawo gawo kagayidwe ka mafuta, owonetsedwa ndi kuchepa kwa mafuta awo, zomwe zimapangitsa kuchepa kwa ingress yamafuta achilengedwe amwazi m'magazi,
• Kuletsa mapangidwe a ma ketoni,
• kuchuluka kwa mafuta acids ndi kutsika kwawo kwamtsogolo, chifukwa chomwe coenzyme yofunika imapangidwa m'thupi,
• kutenga nawo gawo mumapuloteni, omwe amaphatikiza kuwongolera kwa ma amino acid m'maselo, kulimbikitsa kupanga ma peptides, kuchepetsa kugwiritsa ntchito mapuloteni pogwiritsa ntchito minofu, komanso kuletsa mapangidwe a ma keto acid kuchokera ku amino acid.
• kutsegula kapena zoletsa zamitundu mitundu ya michere.

Ma insulini ndi njira yoyamba yolowera m'malo ochizira matenda ashuga. Kusankha kwa mankhwala kumadalira kuuma ndi machitidwe a matendawa, mkhalidwe wa wodwalayo komanso kuthamanga ndi kutalika kwa zotsatira za hypoglycemic. Chithandizo chimachitika molingana ndi njira zomwe munthu amagwiritsa ntchito, zomwe zimapangitsa kuti ma insulin azikonzekera.

Mitundu yazakudya mukamagwiritsa ntchito insulin iyenera kuchepetsedwa ndi mphamvu ya chakudya kuchokera 1700 mpaka 3000 kcal.

Mukamasankha mulingo, shuga ndi mkodzo amayeza pamimba yopanda kanthu tsiku lonse. Kutsimikiza komaliza kumakhala kuchepa kwa hyperglycemia, glycosuria, kutengera thanzi la wodwalayo.

Biosulin P nthawi zambiri imayang'aniridwa mosagwirizana, nthawi zambiri - intramuscularly. Mayamwidwe ndi nthawi ya chitukuko cha zotsatira zimatengera osati njira ya makonzedwe, komanso malo, kuchuluka ndi kuchuluka kwa insulin.

Kutulutsa mawonekedwe ndi kapangidwe kake

Biosulin P imapezeka monga yankho la jakisoni ndi mulingo wa 100 U / 1 ml. Botolo limatha kukhala ndi 5 ml kapena 10 ml, 1, 2, 3 kapena 5 paz pack. Wopanga mankhwalawa ndi Marvel LifeSciences (India).

Mulinso:

• insulin yosungunuka - 100 mg,
• otulutsa osiyanasiyana.

Mankhwalawa ndi a gulu la ma insulin omwe amagwiritsidwa ntchito ngati mankhwala ochiritsira, amapangidwa ndi njira yopangira ma genetic, ndipo amumwa mankhwala.

Kupanga ndi mawonekedwe a kumasulidwa

mu 10 ml Mbale, mu paketi ya makatoni 1 botolo kapena makatoni a 3 ml, mu blister pack 5 ma PC.

Zizindikiro zogwiritsidwa ntchito

• insellinus wodwala matenda a shuga (mtundu I),
• mtundu wosagwirizana ndi insulin wodwala matenda a shuga mellitus (mtundu II) ndi chitukuko chokana mankhwala osokoneza bongo a hypoglycemic,
• mtundu wosagwirizana ndi insulin wodwala matenda a shuga mellitus (mtundu II) ndi chitukuko cha kukana pang'ono kwa mankhwala amkamwa a hypoglycemic popereka mankhwala othandizira,
• Matenda omwe amagwirizana (matenda owopsa omwe amasokoneza njira ya matenda amiseche amtundu uliwonse),
• kuwonongeka kwa kagayidwe kazakudya, komwe kumayambitsa mwadzidzidzi anthu omwe ali ndi matenda ashuga.

Kuphatikiza apo, monga adokotala adalamulira, ma insulin angagwiritsidwe ntchito pazinthu zotere:

• pokonzekera opareshoni ya odwala omwe ali ndi matenda a shuga a II,
• ndi matenda ashuga mwa amayi apakati,
• Ngati mankhwala a anabolic atopa kwambiri,
• ndi furunculosis,
• ndi hyperthyroidism,
• ndi atony kapena ptosis yam'mimba,
• matenda a chiwindi,
• ndi matenda a chiwindi kumayambiriro kwa matenda,
• mu mkhalidwe wa hypoglycemic coma,
• monga mankhwala a mtima pachimake kulephera.

Contraindication

Biosulin P yotsutsana:

• ndi chidwi chachikulu ndi zomwe zikuchitika kapena zinthu zina za mankhwala,
• ali ndi vuto la chiyambi,
• mu pachimake chiwindi, kapamba, matenda aimpso,
• ndi zilonda zam'mimba zam'mimba,
• ali ndi vuto la mtima paziwongola,
• ndi mtima kulephera.

Njira yogwiritsira ntchito

Mankhwalawa amatumizidwa mphindi 30 asanadye. Mlingo amasankhidwa ndi dokotala payekhapayekha.

Pafupifupi kuchuluka kwa tsiku lililonse kuyambira 0,5 mpaka 1 IU pa kilogalamu yodwala.

Mukamagwiritsa ntchito Biosulin P ngati mankhwala amodzi, imayendetsedwa katatu / tsiku kapena kuwonjezeka mpaka 5-6 ngati kuli kofunikira. Pa mlingo wopitilira 0.6 IU / kg patsiku, uyenera kugwiritsidwa ntchito m'malo osiyanasiyana momwe amapangira jakisoni a 2 kapena kuposa.

Malo omwe jekeseni wambiri wa Biosulin P ndi khoma lam'mimba, koma angagwiritsidwe ntchito matako, ntchafu, ndi mapewa. Popewa kukula kwa adipose minofu ya dyipophy pamalowo jakisoni, tsamba la jakisidwe liyenera kusinthidwa.

Intramuscular and intravenous management imachitika kokha moyang'aniridwa ndi dokotala.

Mawu oyamba ndi awa:

• ndi zala ziwiri amapanga khola,
• singano imayikidwira m'chiyeso chake madigiri 45,
• mwanjira yoyendetsera ndikuwongolera kwathunthu, gwiritsani singano kwa masekondi angapo pansi pa khungu, ndiye kuti muchotse.

Ngati magazi atuluka pamalo a jakisoni, asindikizeni ndi chala chanu ndikuigwira.

Zotsatira zoyipa

• hypoglycemia, yowonetsedwa ndi pallor, thukuta kwambiri, tachycardia, kugwedezeka, kugunda kwa zinthu, njala. Kuchuluka kwa hypoglycemia kumabweretsa chikomokere.
• redness, kuyabwa ndi kutupa pamalo a jakisoni,
• adipose minofu ya dyipogu akapatsidwa malo amodzi,
• Hypersensitivity zimachitika mu mawonekedwe a totupa, edema wa Quincke, anaphylaxis sizotheka kwenikweni,
• kutupa kapena kuwonongeka koyambira koyamba kwa chithandizo.

Zomwe zimayambitsa chitukuko cha dziko la hypoglycemic zitha kukhala:

• bongo
• m'malo mankhwala
• kusowa kwa chakudya atamwa mankhwala,
• kusanza, kutsegula m'mimba,
• zochita zolimbitsa thupi,
• matenda omwe kuchepa kwa thupi kukufunika kwa mahomoni, monga matenda a chiwindi kapena impso, kuchepa kwa ntchito ya gren, gitu kapena chithokomiro.
• mogwirizana ndi mankhwala ena.

Malangizo apadera

• Mtundu wa yankho umasintha, kuwoneka kwamtopola kapena tinthu tating'onoting'ono, kugwiritsidwanso ntchito kumatsutsana.
• Mankhwala akukonzekera insulin, ndikofunikira kuyang'anira kuchuluka kwa shuga m'magazi,
• ndi yopuma yayitali pakati pa kukhazikitsa kapena kugwiritsa ntchito Mlingo wolakwika, kukula kwa hyperglycemia ndikotheka, komwe kumawonetsedwa ndikumva ludzu, kukodza pafupipafupi, nseru komanso kusanza, mawonekedwe a redness ndi kuuma kwa khungu, kuchepa kwa chilimbikitso ndi kununkhira kwa acetone kuchokera kwa wodwala. Pokhapokha ngati pali chithandizo chamankhwala otere, ndikotheka kukhala ndi ketoacidosis, womwe ndiwopseza moyo,
• ndi kuchuluka kwa zochitika zolimbitsa thupi, matenda, kutentha thupi, matenda a chithokomiro, chiwindi, impso ndi zina, komanso zaka zopitilira 65 komanso kusintha kwa zakudya, mlingo wa mankhwalawa umayenera kusinthidwa,
• matenda ena amatha kuwonjezera kufunika kwa insulini (mwachitsanzo, matenda osiyanasiyana omwe ali ndi kutentha kwambiri),
• posintha mankhwalawa, kayendedwe ka shuga m'magazi ndikofunikira,
• Biosulin P amachepetsa kuyamwa kwa mowa,
• kugwiritsa ntchito mapampu a insulini sikulimbikitsidwa chifukwa chogwiritsa ntchito mankhwalawa mu catheters.
• Ndi kusintha kosiyanasiyana komwe kumachitika chifukwa cha insulin, kuchepa kwa kuyendetsa kapena kugwira ntchito yomwe ikufunika chidwi chochulukirapo kungaoneke.

Kuyanjana kwa mankhwala

• kuchuluka kwa kuchepetsa shuga kwa Biosulin P kumawonedwa tikamamwa: mapiritsi a kuchepetsa shuga; maziko a lithiamu, omwe amakhala ndi mankhwala osokoneza bongo.
• kuchepa kwa zotsatira za hypoglycemic kumachitika mukamamwa mankhwala oletsa kubereka a m'magazi, glucocorticosteroids, mahomoni a chithokomiro, mankhwala ena okodzetsa, heparin, mankhwala a sympathomimetic, danazole, clonidine, antihypertensive mankhwala, diazoxide, narcotic analgesics, nikotini.
• Reserpine ikhoza kufooka ndikuwonjezera zochita za Biosulin R.

Analogues a Biosulin P ndi omwe amangokhala osakhalitsa ndi mankhwala ofanana nawo:

• Actrapid NM imapezeka m'mbale 10 ml. Wopanga: Novo Nordisk (Denmark). Actrapid NM Penfill kuchokera kwa wopanga yemweyo amapezeka katiriji 3 ml kwa penfill. Pali ma cartridge 5 pa paketi iliyonse,
• Vosulim-R imabweranso momwe makatoni ndi miphika, zopangidwa ndi Wockhardt Limited (India),
• Gensulin R ya kampani yopanga zoweta, kampani yopanga: Bioton Vostok ZAO (Russia),
• Insuman Rapid GT, Aventis Pharma Deutschland GmbH (Germany),
• Insuran R imapangidwa ndi Institute of Bioorganic Chemistry. Ophunzira M.M.Shemyakin ndi Yu.A. Ovchinnikov RAS (Russia),
• Monoinsulin CR, Belmedpreparaty RUE (Republic of Belarus),
• Rinsulin R, GEROFARM-Bio OJSC (Russia),
• Rosinsulin R, Mtengo wa Medsintez (Russia),
• Humulin Regular, Lilly France (France).

Mankhwala

Ndi insulin yaumunthu yomwe imapezeka pogwiritsa ntchito ukadaulo wa DNA.

Imalumikizana ndi cholandirira chapadera pa cell ya cytoplasmic maselo ndikupanga insulini-receptor zovuta zomwe zimapangitsanso njira zina, kuphatikizapo kaphatikizidwe angapo ofunikira a michere (hexokinase, pyruvate kinase, glycogen synthetase). Kutsika kwa glucose m'magazi kumachitika chifukwa cha kuchuluka kwa kayendedwe kazinthu zosafunikira, kuchuluka kwa mayamwa komanso kusokonekera kwa minofu, kukondoweza kwa lipogenesis, glycogenogeneis, ndi kuchepa kwa kuchuluka kwa shuga m'magazi.

Kutalika kwa nthawi ya kukonzekera kwa insulin kumachitika makamaka chifukwa cha kuchuluka kwa mayamwidwe, zomwe zimatengera zinthu zingapo (mwachitsanzo, mlingo, njira ndi malo oyang'anira), chifukwa chake zochitika za insulin zimasinthasintha kwambiri, mwa anthu osiyanasiyana komanso kwa munthu yemweyo .

Pambuyo pa sc makonzedwe, kuyamba kwa mankhwala amadziwika pambuyo pafupifupi mphindi 30, mphamvu yayikulu ikupezeka pakati 2 mpaka 4 maola, nthawi ya kuchitapo ndi maola 6-8.

Pharmacokinetics

Kukwanira kwathunthu ndi kuyambika kwa mphamvu ya insulin kumatengera njira yoyendetsera (sc kapena intramuscularly) ndi malo oyang'anira (m'mimba, ntchafu, matako), mlingo (kuchuluka kwa insulin), komanso kuchuluka kwa insulin pokonzekera.

Imagawidwa mosiyanasiyana mu minofu. Sichidutsa chotchinga ndipo sichikumbukiridwa mkaka wa m'mawere.

Amawonongedwa ndi insulinase makamaka m'chiwindi ndi impso.

T_1/2 - mphindi zochepa. Kuthira mkodzo - 30-80%.

Zisonyezero za mankhwala Biosulin ® R

lembani matenda a shuga 1 mellitus (wodalira insulin),

lembani matenda a shuga a 2 a mellitus (osadalira insulini): gawo la kukana kwa othandizira a hypoglycemic, osagwirizana ndi mankhwalawa (panthawi yophatikiza mankhwalawa), matenda ogwirizana,

mwadzidzidzi zinthu odwala matenda a shuga, limodzi ndi kuwonongeka kwa chakudya.

Kuchita

Pali mankhwala angapo omwe amakhudza kufunika kwa insulin.

Hypoglycemic zotsatira za insulin patsogolo mankhwala m'kamwa hypoglycemic, Mao zoletsa, zoletsa Ace, carbonic zoletsa anhydrase, kusankha beta-blockers, bromocriptine, octreotide, sulfonamides, anabolic mankhwala, tetracyclines, clofibrate, ketoconazole, mebendazole, pyridoxine, cyclophosphamide, fenfluramine, lifiyamu, mankhwala, yokhala ndi Mowa.

Kulera kwapakamwa, corticosteroids, mahomoni a chithokomiro, thiazide diuretics, heparin, tridclic antidepressants, sympathomimetics, danazole, clonidine, BKK, diazoxide, morphine, phenytoin, nikotini kufooketsa mphamvu ya hypoglycemic.

Mothandizidwa ndi reserpine ndi salicylates, kufooka komanso kuwonjezeka kwa machitidwe a mankhwalawa ndizotheka.

Bongo

Zizindikiro hypoglycemia imayamba.

Chithandizo: wodwalayo amatha kuthetsa hypoglycemia wofatsa mwa kudya shuga kapena zakudya zopatsa mphamvu. Chifukwa chake, ndikulimbikitsidwa kwa odwala matenda ashuga kuti azinyamula shuga, msuzi wa zipatso kapena maswiti ena nawo.

Wovulala kwambiri, wodwalayo akapanda kuzindikira, yankho la dextrose 40% limayendetsedwa iv, i / m, s / c, iv glucagon. Pambuyo pakupezanso chikumbumtima, wodwalayo akulimbikitsidwa kudya zakudya zamafuta ambiri kuti aletse kukonzanso kwa hypoglycemia.

Kutulutsa mafomu ndi kapangidwe kake

Jekeseni wa jekeseni umaperekedwa ngati madzi opanda mandala. Monga pawiri yogwira, 1 ml ya kuyimitsidwa ili ndi 100 IU ya insulin yaumunthu. Kuwongolera pH yamadzi ndikuwonjezera bioavailability, chophatikiza chophatikizidwa chimaphatikizidwa ndi zinthu zotsatirazi:

• metacresol
• madzi osalala
• 10% yankho la caustic koloko,
• yankho la hydrochloric acid 10% ya ndende.

Biosulin imapezeka m'mabotolo agalasi kapena makatoni okhala ndi 3 ml, omwe amapangidwa kuti agwiritsidwe ntchito ndi cholembera cha cholembera cha Biomatic cholembera. Bolodi yokhala ndi makatoni okhala ndi zotengera 5 zonyamula matuza.

Zotsatira za pharmacological

Insulin imatsata kapangidwe ka timadzi ta pancreatic ya munthu kudzera pakubwezeretsanso kwa DNA. Mphamvu ya hypoglycemic imachitika chifukwa chomanga chinthu chogwira ntchito mpaka zolandilira kunja kwa membrane wa khungu. Chifukwa cha phatikizoli, maselo okhala ndi insulin amapangidwa, omwe amathandizira ntchito ya enzymatic ya hexose-6-phosphotransferase, kaphatikizidwe ka chiwindi cha glycogen ndi kupasuka kwa shuga. Zotsatira zake, kuchepa kwa magazi m'magazi a seramu kumawonedwa.

Biosulin P imawonjezera mapangidwe a glycogen ndi mafuta achilengedwe kuchokera ku glucose, amachepetsa njira ya gluconeogenesis m'chiwindi.

The achire zotsatira zimatheka mwa kuwonjezera mayamwidwe a shuga ndi minofu. Kuyendetsa kwake mkati mwa maselo kumakulitsidwa. Mapangidwe a glycogen ndi mafuta achilengedwe kuchokera ku shuga amawonjezereka, ndipo njira ya gluconeogeneis mu chiwindi imachepa.

Kutalika kwa zotsatira za hypoglycemic amawerengedwa potengera kuchuluka kwa kukakamira, komwe, zimatengera malowa ndi njira yoyendetsera insulin, mikhalidwe ya munthu wodwala matenda ashuga. Pambuyo pamakonzedwe a subcutaneous, achire zotsatira zimawonedwa pambuyo pa theka la ola ndikufika pakulimba kwambiri pakati pa maola atatu ndi anayi mutatha kugwiritsa ntchito cartridge. Zotsatira za hypoglycemic zimatha kwa maola 6-8.

Bioavailability ndi isanayambike achire zotsatira zimadalira zotsatirazi:

• njira ya ntchito - subcutaneous kapena mu mnofu jekeseni amaloledwa,
• kuchuluka kwa mahomoni omwe adayambitsidwa
• tsamba la jakisoni (rectus abdominis, ntchafu ya kunja, gluteus maximus),
• insulin ndende.

Ma hormone opangidwa mwachilengedwe amagawidwa mosiyanasiyana m'thupi. Pulogalamu yogwira imawonongeka mu hepatocytes ndi impso. Hafu ya moyo ndi mphindi 5-10. Zomwe zimagwira zimachoka m'thupi ndi 30-80% ndi mkodzo.

Insulin ili ndi vuto lalifupi.

Kutalika kwa zotsatira za hypoglycemic amawerengedwa potengera kuchuluka kwa kukondoweza.

Momwe mungatengere Biosulin P

Mlingo wa insulin umatsimikiziridwa ndi katswiri wazachipatala payekhapayekha, malinga ndi zomwe zimawonetsa shuga. Biosulin imaloledwa kuthandizidwa mosasamala, m'malo okhala ndi minofu yambiri. Munthu amene amalimbikitsidwa kudya munthu wamkulu tsiku lililonse ndi 0,5-1 IU pa 1 makilogalamu (pafupifupi 30 mpaka 40).

Akatswiri azachipatala amalangizidwa kupereka mankhwalawa mphindi 30 asanayambitse zakudya zomwe zimapangidwa ndi chakudya. Pankhaniyi, kutentha kwa mankhwala omwe amaperekedwa kuyenera kukhala kofanana ndi kutentha kozungulira. Ndi monotherapy yokhala ndi Biosulin, wothandizirana ndi hypoglycemic amaperekedwa katatu patsiku, pamaso podyera pakati pa chakudya, pafupipafupi jakisoni amawonjezeka mpaka 5-6 patsiku. Ngati mulingo woposa 0,6 IU pa 1 makilogalamu a kulemera kwa thupi, ndikofunikira kupanga majakisoni awiri m'magawo osiyanasiyana amthupi osati m'dera limodzi lokha.

Ndikofunikira kupaka jekeseni wamankhwala pakhungu pa minofu ya rectus abdominis, kutsatira njira ya algorithm yochita:

1. Patsamba lamayendedwe ofunikira, muyenera kusonkhanitsa khungu lanu pogwiritsa ntchito chala chachikulu ndi chofera. Singano ya syringe iyenera kuyikika pakhungu la pakhungu la 45 ° ndipo piston imatsitsidwa.
2. Pambuyo pakuyambitsa insulini, muyenera kusiya singano pansi pa khungu kwa masekondi 6 kapena kuposerapo kuti muwonetsetsetsetsetsetse kuti mukuyendetsa bwino mankhwala.
3. Pambuyo pochotsa singano, magazi amatha kutuluka m'malo a jakisoni. Dera lomwe lakhudzidwalo liyenera kukanikizidwa ndi chala kapena ubweya wa thonje wothira mowa.

Komanso, jakisoni aliyense amayenera kuchitidwa mkati mwa malire a anatomical, ndikusintha jakisoni. Izi ndizofunikira kuti muchepetse mwayi wa lipodystrophy. Kubayidwa mu mnofu ndi jekeseni wamitsempha kumachitika kokha ndi akatswiri azachipatala. Insulin yogwira ntchito mwachidule imaphatikizidwa ndi mtundu wina wa insulini womwe umathandizanso kuti ukhale wotalikirapo.

Ndi monotherapy ndi Biosulin, wothandizira wa hypoglycemic amaperekedwa katatu patsiku.

Kuyenderana ndi mowa

Mowa wa Ethyl umakhudza kayendedwe ka magazi ndi magwiridwe antchito a chiwindi ndi impso. Zotsatira zake, kagayidwe ka insulin kamasokonekera, komwe kungayambitse kutayika kwa glycemic control. Mwayi wopanga hypoglycemia ukuwonjezeka. Chifukwa chake, munthawi ya chithandizo ndi mankhwalawa, ndizoletsedwa kumwa zakumwa zoledzeretsa.

Mankhwalawa amatha kusintha mitundu yotsatirayi ya insulin:

• Insuman Rapid GT,
• Actrapid NM Ndalama,
• Gensulin P,
• Humulin Wokhazikika.

Ndemanga za Biosulin P

Mankhwalawa adakhazikika pamsika wamankhwala chifukwa chakuyankha kwabwino kwa madokotala ndi odwala.

Elena Kabluchkova, endocrinologist, Nizhny Novgorod

Njira yothandiza yochokera ku insulin yomwe imathandizira odwala matenda a shuga mwadzidzidzi. Cholembera cha syringe ndichabwino kwa odwala omwe ali ndi ndandanda yosinthika ya moyo ndi ntchito. Kuchita kochepa kumathandiza kuthana ndi shuga wambiri. Chifukwa cha kuthamanga kwathanzi lanu, mutha kugwiritsa ntchito cartridge musanadye. Biosulin imaloledwa kugwiritsidwa ntchito ndi mankhwala ena potengera insulin. Odwala atha kulandira mankhwala kuchotsera.

Olga Atamanchenko, endocrinologist, Yaroslavl

Muzochita zamankhwala, ndakhala ndikukulemberani mankhwalawa kuyambira mu Marichi 2015. Kubwera kwa mtundu wa insulin mu matenda ashuga, moyo umakhala bwino, mwayi wa hyperglycemia ndi hypoglycemia umachepa. Amaloledwa kugwiritsidwa ntchito mwa ana ndi amayi apakati. Chifukwa cha insulin yochepa, wodwala amatha kupereka mankhwalawa panthawi yadzidzidzi (yokhala ndi shuga yambiri). Ndimaona kuti Biosulin ndiwothandiza mwachangu, komanso wathanzi.

Stanislav Kornilov, wazaka 53, Lipetsk

Kugwiritsa ntchito bwino insulin. Ndidagwiritsa ntchito Gensulin ndi Farmasulin, koma nditha kukwaniritsa kutsika kwamphamvu kwa glucose kokha chifukwa cha Biosulin. Mankhwala adziwonetsa okha kuphatikiza Insuman Bazal - insulin yayitali. Chifukwa cha kuthamanga kwake, adatha kukulitsa kudya kwa zipatso. Ndinaona kuti kuchokera kumankhwala am'mbuyomu mutu wanga umandipweteka, koma zotsatirapo zake sizimawonedwa. Ndine wokhutira ndi zotsatira zake, koma chinthu chachikulu ndikutsatira malangizo ogwiritsa ntchito komanso zakudya zomwe mwapatsidwa.

Oksana Rozhkova, wazaka 37, Vladivostok

Zaka 5 zapitazo, anali chisamaliro chovuta kwambiri chifukwa cha kufalikira kwa matenda a shuga, omwe samadziwa. Atafika pakulamulira kwa glycemic, adotolo adalankhula za kupezeka kwa mankhwalawo ndipo adalamula biosulin mosalekeza. Anatinso ndizosavuta kugwiritsa ntchito cholembera. Pomwe mankhwalawo anali atabayidwa, mitengo ya shuga idakhalabe yochepa. Koma insulin yamtunduwu imagwiranso ntchito kwakanthawi, ndipo kunali kofunikira kusankha mitundu inanso yotalikirapo. Ndinkawopa kuti mankhwalawa angagwirizane, koma kukayikira sikunatsimikizike. Ndibwino kuphatikiza ndi mtundu wina wa insulin.