Antibiotic Bayer Avelox > Chithandizo ndi kupewa

Moni kwa inu!

Avelox adandiuza kuti azindipanga ndi matenda azachipatala, motero abambo mwina ali ndi zonse zomwe zalembedwa, ndibwino osawerenga.

Zaka ziwiri zapitazo, ndidalemba kale ndemanga pamutuwu "ndili ndi zonunkhira zoyipa"kotero ndidatumizidwa:

Kenako ndidayenera kuvutika: chithandizo sichimapereka zotsatira zake nthawi yomweyo. Ndipo nthawi iyi zinali zofanana.

Sindikudziwa zomwe zikuchitika ndi thupi langa, koma vuto ndi smear yoyipa - maselo oyera oyera okwezeka -

unandichezeranso chaka chino. Ndipo sizimawoneka zovulaza, panali zovuta zina zokha, zomwe nthawi zambiri zimachitika muzochitika zotere.

Mwambiri, ndine mlendo pafupipafupi wopita kuchipatala: kukonzekera ma ultrasound kawiri pachaka komanso kufunsidwa kwa dokotala wazamankhwala a gynecologist-endocrinologist. Chowonadi ndi chakuti kuzindikira kwanga kwakanthawi kokwanira ndi endometrial hyperplasia.

Posachedwa, ndidaphunzira kuti ndi endometrial hyperplasia yomwe imatha kudzutsa leukocytes mu smear - popeza zotupa za endometrium zimapezekapezeka mchiberekero.

Dokotala adalimbikitsanso kuti achite hysteroscopy, koma kuyesa "zabwino" ndikofunikira m'njira iyi. Kuti ndichite izi, ndinayamba kupatsidwa makandulo, kenako - nditapita kwa dotolo, hape.

Gynecologist woyamba adalemba makandulo a Fluomizinum

Koma chithandizo chawo, ngakhale chinali chabwino, sichinathandize zotsatira za smear, - malinga ndi adotolo, adakula kwambiri.

Monga dokotala wazachipatala, sindikudziwa zomwe adawongolera - sindinathenso chifukwa cha ma ultrasound - adalemba mankhwala olimbitsa kwambiri a m'badwo watsopano - Avelox.

Mukunditsimikizira kuti "adzathandiza nthawi yomweyo!", Komanso anandipatsa mankhwala ena angapo omwe angateteze kuoneka kwa dysbiosis ndi thrush.

Kwakukulukulu, chithandizo changa chidalandira ndalama!

Musanatenge avelox Ine, mwachizolowezi, ndimawerenga ndemanga, pomwe zidadziwika kuti thupi langa silingasinthe Avelox, popeza ndili ndi vuto la chikhodzodzo, ndikutiizi zikutanthauzapafupifupi matenda onse amathandiza.

Kugwiritsa

Ndinkamwa piritsi la Avelox 1 tsiku litatha kudya, nditatsuka ndimadzi kwa milungu iwiri.

Ndidayesa kuti ndisasunthire nthawi yodyera kuti pasakhale katundu mthupi losafunikira.

Zizindikiro

Matenda opatsirana komanso otupa kwa akuluakulu omwe amapangidwa ndi tizilombo tating'onoting'ono tokhudza mankhwala: pachimake sinusitis, chibayo chomwe chimagwiritsidwa ntchito ndi anthu ena (kuphatikizapo omwe amayamba chifukwa cha ma microorganism omwe ali ndi ma antioxotic ambiri), kuchuluka kwa chifuwa, matenda osavuta a pakhungu ndi minofu yofewa. kapangidwe kake (kuphatikiza phazi la matenda ashuga), matenda ophatikizika am'mimba, kuphatikizapo matenda a polymicrobial intraperitoneal abscesses, zosavuta zotupa matenda a m'chiuno ziwalo (kuphatikizapo salpingitis ndi endometritis).

Contraindication

pakati, kuyamwitsa (yoyamwitsa),
ana ndi achinyamata osakwana zaka 18,
Hypersensitivity kuti moxifloxacin ndi zina za mankhwala.

Zotsatira zoyipa

Kuchulukitsa kwakanthawi kwa QT (nthawi zambiri mwa odwala omwe ali ndi concomitant hypokalemia, nthawi zina mwa odwala ena), tachycardia ndi vasodilation (kuthina kwa nkhope), ochepa hypotension, ochepa hypertension, kukomoka, kwamitsempha yamagazi tachyarrhythmias, kuphatikiza kwapafupipafupi (ventricular pirouette mtundu arrhythmia) kapena mtima omangidwa makamaka mwa anthu omwe ali ndi chiyembekezo choganiza za arrhythmias, monga bradycardia yayikulu, pachimake myocardial ischemia, kupuma movutikira, kuphatikiza ac masamu, nseru, kusanza, kupweteka kwam'mimba, kutsegula m'mimba, matenda am'mimba, kudzimbidwa, dyspepsia, flatulence, gastroenteritis (kupatula gastroenteritis), stomatitis, pseudomembranous colitis (nthawi zina zimagwirizana ndi zovuta zowopsa), jaundice, hepatitis (makamaka cholestate ), chizungulire, kupweteka mutu, kusokonezeka, kusokonezeka, kugona, kugwedezeka, kugona, nkhawa, kuchuluka kwa zochitika za psychomotor, mgwirizano wolakwika (kuphatikiza kusokonezeka chifukwa cha chizungulire. Ine, m'malo osowa kwambiri, ndikubweretsa kuvulala chifukwa cha kugwa, makamaka odwala okalamba), ndimagwidwa mwamantha ndimankhwala osiyanasiyana (kuphatikizapo kukomoka kwa Grand mal), kusokonezeka kwa chidwi, vuto la kuyankhula, kukangana, kuvutika maganizo (m'malo osowa kwambiri, kukhala ndi chizolowezi chodzivulaza ndikotheka), kuyerekezera zinthu zina, kutengeka ndi malingaliro (mwanjira yowoneka ndi chizolowezi chodzivulaza), kusokoneza kukoma, kusokonezeka kowoneka (kusokonezeka, utachepa kowoneka bwino, diplopia, makamaka kuphatikiza chizungulire komanso chisokonezo), tinnitus, kuphwanya kununkhira, kuphatikiza elemia, kuchepa kwa chidwi champhamvu, kuchepa magazi, leukopenia (kuphatikizapo neutropenia), thrombosis cytopenia, thrombocytosis, nthawi yayitali prothrombin ndi kuchepa INR, arthralgia, myalgia, tendonitis, minofu kamvekedwe ndi kukokana, kupindika kwa tendon, kufalitsa zamkati, vaginitis, kuchepa kwa madzi m'mimba (chifukwa cha kutsegula m'mimba kapena kuchepa kwa magazi) , zomwe zingayambitse kuwonongeka kwa impso (makamaka kwa odwala okalamba omwe ali ndi vuto laimpso), mawonekedwe amkati pakhungu mwachitsanzo, matenda a Stevens-Johnson kapena poyizoni. epermermal necrolysis (yoopsa moyo), urticaria, pruritus, zidzolo, eosinophilia, anaphylactic / anaphylactoid zimachitika, angioedema, kuphatikizapo laryngeal edema (moopseza moyo), anaphylactic mantha yowopseza moyo), malaise yodziwika bwino (kuphatikiza zizindikiro zaumoyo wopanda vuto, kupweteka mosasamala komanso thukuta), kutupa.

Kupanga

Mphamvu yogwira: moxifloxacin hydrochloride - 436.8 mg

Mawonekedwe

Mapiritsi, monga mukuwonera, ndi okulirapo, koma chifukwa cha mawonekedwe awo obisika amakhala oledzera.

Mlingo

400 mg mapiritsi okhala ndi mafilimu

Piritsi limodzi lili

akntchito yogwira - moxifloxacin hydrochloride 436.8 mg,

(ofanana ndi moxifloxacin 400.0 mg),

zokopa: lactose monohydrate, microcrystalline cellulose, croscarmellose sodium, magnesium stearate,

kapangidwe ka chipolopolo: iron oxide ofiira, hypromellose, macrogol 4000, titanium dioxide.

Mapiritsi okhala ndi ofiira ofunika a Oblong, okutidwa, pafupifupi 17 mm kutalika kwake ndi 7 mm, anali ndi "M 400" mbali imodzi ndi "BAYER" mbali inayo.

Mankhwala

Pharmacokinetics

Kubzala ndi bioavailability

Mukamamwa pakamwa, moxifloxacin imagwira msanga komanso pafupifupi. Mtheradi bioavailability pafupifupi 91%.

Mankhwala a moxifloxacin atamwa pa 50 mpaka 1200 mg kamodzi, komanso 600 mg / tsiku kwa masiku 10, ali pamzere. Dera lolingana limafikiridwa pakatha masiku atatu.

Pambuyo pa mlingo umodzi wa 400 mg wa moxifloxacin, ndende yolemekezeka (C max) m'magazi imafikiridwa mkati mwa maola a 0.5-4 ndipo ndi 3.1 mg / l. Peak ndi zochepa za plasma za malo okhazikika (400 mg kamodzi tsiku lililonse) zinali 3.2 ndi 0,6 mg / L, motsatana.

Mukamamwa moxifloxacin ndi chakudya, pamakhala kuwonjezeka pang'ono panthawiyi kuti mufikire Cmax (pofika maola 2) ndi kuchepa pang'ono kwa Cmax (pofika pafupifupi 16%), pomwe nthawi yolemba sichisintha. Komabe, izi ndizosafunikira kwenikweni, popeza kuchuluka kwa AUC / MIC kumaneneratu zochita za antinicrobial za quinolones. Chifukwa chake, mankhwalawa amatha kugwiritsidwa ntchito mosasamala zakudya.

Moxifloxacin imagawidwa mwachangu pabedi. Pali malo akulu pansi pa AUC pharmacokinetic curve (AUCnorm = 6 kg * maola / L) yokhala ndi voliyumu yotsatsira (Vss) ya moxifloxacin pafupifupi 2 L / kg. Kuchuluka kwa kuchuluka kwa moxifloxacin m'malovu kumakhala kwakukulu kuposa plasma. Mu ma in vitro ndi mu vivo maphunziro omwe ali mu ndende kuchokera ku 0.02 mpaka 2 ml / l, kumangidwa kwa moxifloxacin kumapuloteni anali pafupifupi 45%, mosasamala kanthu za kuchuluka kwa mankhwalawa.

Moxifloxacin imagwiritsidwa ntchito makamaka ndi plasma albin.

Pali nsonga yayikulu pamisasa yaulere> 10xMIC chifukwa chamagetsi ochepera.

Kuzama kwambiri kwa mankhwalawa, ochulukirapo kwa omwe amapezeka m'madzi a m'magazi, kumapangidwa minofu yam'mapapu (epithelial fluid, macrophages alveolar, minofu yachilengedwe), mu sinuses ndi polyps, pamtsinje wa kutupa. Malovu, interstitial madzimadzi (intermuscular and subcutaneous), kuchuluka kwamankhwala kumakhala mwaufulu kutsimikiza.

Kuphatikiza apo, kuchuluka kwa mankhwalawa kumatsimikiziridwa mu ziwalo zamkati mwam'mimba komanso madzimadzi a peritoneal, komanso kumaliseche kwamkazi.

Patatha kamodzi muyezo wa moxifloxacin 400 mg, panjira zonse ziwiri za kayendetsedwe, poyerekeza kuchuluka kwazowunikira zikuwonetsedwa poyerekeza ndi kuchuluka kwa plasma m'malo osiyanasiyana osanja.

Pambuyo popita gawo lachiwiri la biotransfform, moxifloxacin imachotsedwa m'thupi ndi impso ndi m'mimba thirakiti (GIT) yonse yosasinthika komanso mawonekedwe osakanikirana a mankhwala a Soffo (M1) ndi glucuronides (M2). Ma metabolites awa amagwira ntchito kokha m'thupi laumunthu ndipo samakhala ndi antimicrobial zochita. Kafukufuku wokhudzana ndi metabolic pharmacokinetic mogwirizana ndi mankhwala ena adawonetsa kuti moxifloxacin sikuti ndi biotransformed ndi microsomal cytochrome P450 system.

Mosasamala kanthu za njira yomwe angagwiritsire ntchito, ma metabolites M1 ndi M2 amapezeka m'madzi am'magazi pozungulira poyerekeza ndi moxifloxacin wosasinthika.

Hafu ya moyo wa mankhwalawa kuchokera m'madzi a m'magazi pafupifupi maola 12. Nthawi zonse chilolezo chitatenga 400 mg kuchokera pa 179 mpaka 246 ml / min. Kuchotsedwako kwa pafupifupi 24-53 ml / mphindi kumachitika mwa kuphatikizanso kwaubongo wa mankhwala mu impso. Kuphatikizika kwa ntchito kwa ranitidine ndi phenenecid sikukhudza kuvomerezeka kwa mankhwalawa. Mosasamala kanthu za kayendetsedwe ka kayendetsedwe, poyambira moxifloxacin pafupifupi 96-98% yopangidwa ndi metabolites ya gawo lachiwiri la metabolism popanda zizindikiro za oxidative metabolism.

Pharmacokinetics m'magulu osiyanasiyana odwala

Zosiyana mu pharmacokinetics za moxifloxacin sizinakhazikitsidwe.

Paulo Kusiyana (33%) mu pharmacokinetics (AUC, Cmax) pakati pa amuna ndi akazi kunawululidwa. Kusiyana komwe kwawululidwa mu AUC ndi Cmax kunalongosoledwa ndi kusiyana kwa kulemera kwa thupi kuposa kutengera jenda. Chifukwa chake, sizofunikira kwambiri pakubadwa.

Kusiyanitsa kothekera kwakadaphunzitsidwa ku Caucasoid, Japan, Negroid, ndi mafuko ena. Kusiyana kwakukulu kwamankhwala mu moxifloxacin sikunakhazikitsidwe.

Ma pharmacokinetics a moxifloxacin mwa ana sanaphunzire.

Panalibe kusintha kwakukulu mu pharmacokinetics ya moxifloxacin mwa odwala omwe ali ndi vuto la Impso (kuphatikiza odwala omwe ali ndi chilolezo cha creatinine cha 1/100 ndi 1/1000 ndi 1/10 0000 ndi 1 / 1,000)

- kusintha kwa thromboplastin ndende

- anaphylactic / anaphylactoid zimachitika, matupi awo sagwirizana / angioedema, kuphatikizapo laryngeal edema (yomwe ikhoza kuwononga moyo)

- kuvutikira m'maganizo, kukhumudwa (nthawi zosowa kwambiri, kuwonetseredwa machitidwe omwe ali ndi chizolowezi chodzivulaza, monga malingaliro ofuna kudzipha kapena kuyesa), kuyerekezera zinthu zina

- hyposthesia, kuphwanya kununkhira, kuphatikiza elemia

- maloto okhathamiritsa, kulumikizidwa mosiyanasiyana (kuphatikiza chizungulire, makamaka chifukwa cha chizungulire kapena vertigo (zomwe zimatsogolera pakugwa, makamaka kwa okalamba omwe ali ndi vuto losowa kwambiri), kugwidwa ndi matenda osiyanasiyana (kuphatikizapo ambiri), kusowa chidwi, mavuto a kulankhula, amnesia

- zotumphukira neuropathy ndi polyneuropathy

- tinnitus, kuwonongeka kwa makutu, kuphatikizapo kugontha (nthawi zambiri kumatha kusintha)

- kukomoka, hypotension, matenda oopsa, yamitsempha yamagazi tachyarrhythmias

- dysphagia, stomatitis, pseudomembranous colitis (omwe amaphatikizidwa ndi zoopsa pangozi nthawi zambiri), jaundice, hepatitis (makamaka cholestatic)

- tendonitis, minofu kamvekedwe ndi minyewa kukokana, kufooka kwa minofu

- aimpso ntchito, aimpso kulephera (chifukwa cha kuchepa madzi m'thupi, makamaka odwala okalamba omwe ali ndi vuto lofanana ndi aimpso)

Kutulutsa mawonekedwe ndi kapangidwe kake

Avelox imapezeka mu mawonekedwe a mapiritsi okhala ndi njira komanso kulowetsedwa.

The yogwira mankhwala ndi moxifloxacin: piritsi limodzi ndi 250 ml ya yankho - 400 mg.

Omwe mapiritsi: lactose monohydrate, microcrystalline cellulose, croscarmellose sodium, magnesium stearate, hypromellose, yellow iron oxide, macrogol 4000, titanium dioxide.

Zothandiza pa yankho: 1M hydrochloric acid, sodium chloride, 2M sodium hydroxide solution, madzi a jakisoni.

Mankhwala

Moxifloxacin (dzina la mankhwala - 8-methoxyfluoroquinolone) ndiwodziwika bwino wa bactericidal antibacterial. Mphamvu yake ya bactericidal imachitika chifukwa chakuti imalepheretsa bakiteriya topoisomerases II ndi IV. Izi zimayambitsa kusokonezeka polemba, kukonza ndi kuyikidwanso kwa biosynthesis ya DNA ya maselo okhala ndi michere ndipo, monga chotulukapo chake, kumatsogolera kuimfayo.

Ma bactericidal ochepera poyerekeza moxifloxacin nthawi zambiri amafanana ndi zochepa zoletsa. Ntchito ya antibacterial ya Avelox sichimatsimikiziridwa ndi zomwe zimapangitsa kuti pakhale kukana kwa ma tetracyclines, penicillins, macrolides, aminoglycosides ndi cephalosporins. Kutsutsa kwapakati pamagulu awa a antibacterial mankhwala ndi moxifloxacin sikunapezeke. Milandu yotsutsana ndi plasmid sikulembedwera pano. Pafupipafupi pafupipafupi pamakhala kukana kumakhala kochepa kwambiri (10 -7 ‒10 -10).

Kukaniza kwa Avelox kumayamba nthawi yayitali kudzera pakusintha kambiri.

Kuwonetsedwa mobwerezabwereza ku gawo logwira ntchito la Avelox m'malingaliro omwe samakwanira phindu la osachepera inhibitory concentration (MIC), kumangowonjezera kuwonjezeka pang'ono kwa MIC.

Pali zochitika zina zotsutsana ndi quinolones. Komabe, ma tizilombo tina a anaerobic ndi gram-positive omwe amalimbana ndi ma quinolones ena amawonetsa chidwi cha moxifloxacin.

Kukhazikitsidwa kuti kuwonjezeranso kwa gulu la methoxy komwe limatulutsa C8 ku moxifloxacin mamolekyulidwe amakulitsa zochitika zake ndikuletsa kupangika kwa mabakiteriya okhala ndi majeremusi oyenda bwino.

Kuphatikizika kwa gulu la baiskcloamine ku molekyulu yomwe ili ndi C7 imalepheretsa mapangidwe ogwira ntchito a efflux komanso limagwirira kukana kwa fluoroquinolones.

In vitro moxifloxacin imagwira ntchito motsutsana ndi tizilombo tambiri ta gramu-gramu komanso gram-negative, anaerobes, atypical and acid zosagwira ma bacteria (mwachitsanzo, Legionella spp., Chlamydia spp., Mycoplasma spp.

Pakadali pano, maphunziro awiri ndi odzipereka amadziwika momwe masinthidwe am'mimba a microflora atatha kuphunzira pakamwa moxifloxacin. Adawonetsa kuchepa kuzungulira kwa Klebsiella spp., Escherichia coli, Enterococcus spp., Bacteroides vulgates, Bacillus spp., Komanso anaerobes Peptostreptococcus spp., Eubacterium spp., Bifidobacterium spp. Kusintha kumeneku kunasinthidwa masabata awiri. Poizoni wa Clostridium ubunzima sanatchulike.

In vitro moxifloxacin ikuwonetsa kwambiri antibacterial zochita motsutsana ndi tizilombo totsatirazi:

Mabakiteriya okhala ndi gram: Gardnerella vaginalis, michere yokhala ndi methicillin yovuta kwambiri ya coagulase-negative staphylococci (S. simulans, S. cohnii, S. saprophyticus, S. epidermidis, S.hominis, S. haemolyticus), Staphylococcus aureus (tizilombo tosonyeza kuchepa kwa methicillin), Streptococcus pneumoniae kuphatikiza tizilombo tosagwirizana ndi penicillin, komanso zovuta zolimbana ndi maantibayotiki ambiri, komanso mitundu yotsutsana ndi maantibayotiki awiri kapena kuposerapo, omwe akuphatikiza ndi maantibayotiki awiri kapena kuposerapo, omwe akuphatikiza trimethoprim / sulfamethoxazole, MIC yoposa 2 μg / ml), ma tetracyclines, cephalosporins am'badwo wachiwiri. , S. thermophilus, S. mutans, S. sa livarius, S. sanguinis, S. mitis), gulu la Streptococcus milleri (S. intermedins, S. constellatus, S. anginosus),
mabakiteriya osagwiritsa ntchito mankhwalawa: Proteus vulgaris, Haemophilus parainfluenzae, Haemophilus influenzae (kuphatikiza tizilombo ta kusakanikirana komanso osapanga β-lactamases), Acinetobacter baumannii, Moraxella catarrhalis (kuphatikiza zingwe zomwe zimatulutsa ndipo sizimapanga β-lactamases, Bordella pneumonia, Bordella pneumonia.
tizilombo ta anaerobic: Propionibacterium spp., Fusobacterium spp., Prevotella spp., Porphyromonas spp.,
tizilombo tating'onoting'ono: Coxiella burnetii, Chlamydia trachomatis, Chlamydia pneumoniae, Mycoplasma genitalium, Mycoplasma hominis, Mycoplasma pneumoniae.

Ma tizilombo totsatirawa ali ndi chidwi ndi moxifloxacin:

Mabakiteriya okhala ndi gram: Enterococcus faechium, Enterococcus avium, Enterococcus faecalis (amangokhala ndi chidwi ndi ma glamicin ndi vancomycin),
mabakiteriya opanda gramu: Providencia spp. (P. stuartii, P. rettgeri), Escherichia coli, Neisseria gonorrhoeae, Klebsiella oxetoca, Klebsiella pneumoniae, Morganella morganii, Citrobacter freundii, Proteus mirabilis, Enterobacter spp. (E. sakazakii, E. intermedius, E. aerogene), Enterobacter cloacae, Stenotrophomonas maltophilia, Burkholderia cepacia, Pseudomonas fluorescens, Pantoea agglomerans,
tizilombo toyambitsa matenda a anaerobic: Clostridium spp., Peptostreptococcus spp., Bacteroides spp. (B. vulgaris, B. fragilis, B. yunifesis, B. distasonis, B. ovatus, B. thetaiotaomicron).

Zamoyo zotsatirazi zikuwonetsa kukana mankhwala:

mabakiteriya okhala ndi gramu: methicillin zosagwira zigawo za coagulase-negative staphylococci (S. simulans, S. cohnii, S. saprophyticus, S. epidermidis, S. hominis, S. haemolyticus), ofloxacin / methicillin zosagwira zotupa za Staphylococcus aureus,
mabakiteriya osagwiritsa ntchito gramu: Pseudomonas aeruginosa.

Kugwiritsa ntchito Avelox sikulimbikitsidwa pochiza matenda oyambitsidwa ndi tizilombo ta Staphylococcus aureus okhala ndi chitsimikizo chotsutsana ndi methicillin (MRSA). Ngati mankhwalawa atheka kapena matenda atatsimikiziridwa ndi a MRSA, mankhwala omwe ali ndi antibacterial oyenera ayenera kuperekedwa.

Kwa zovuta zina, kukana komwe mungapeze kumatha kufalikira mosiyanasiyana kwa nthawi komanso kutengera komwe madera ali. Pachifukwachi, mukamayesa kumva kukhudzika, tikulimbikitsidwa kuti muphunzire zambiri zam'deralo pakukana, makamaka pochiza matenda opatsirana.

Ngati odwala akumalandira kuchipatala, kufunika kwa malo omwe ali pansi pa pharmacokinetic pamapindikira "nthawi -" (AUC) / MIC₉₀ yoposa 125, ndipo zonse za moxifloxacin m'magazi am'madzi (C_max) / MIC₉₀ ili pamtunda wa 8-10, izi zikutanthauza kupitiliza bwino kwa odwala komanso kusintha kwachipatala. Muzochitika, zizindikirozi nthawi zambiri zimakhala zochepa (AUC / MIC₉₀ uzitha 30- 40).

Mukamamwa mawonekedwe a Avelox: ndi MIC wamba₉₀ 0,125 mg / ml AUIC (dera lomwe lili pansi pa zopondaponda, i.e. chiyezo cha AUC / MIC)₉₀) ndi wofanana ndi 279, ndi C_max/ MIC₉₀ - 23,6. Ndi MIC mfundo₉₀ 0.25 mg / ml ndi 0,5 mg / ml AUIC ndi C mfundo_max/ MIC₉₀ ali onse 140 ndi 11.8 pa oyambayo ndipo 70 ndi 5.9 pankhani yachiwiri.

Ndi kulowetsedwa kwa mtsempha: ndi MIC wamba₉₀ 0.125 mg / ml AUIC ndi 313 ndi C_max/ MIC₉₀ - 32.5. Ndi MIC mfundo₉₀ 0.25 mg / ml ndi 0,5 mg / ml AUIC ndi C mfundo_max/ MIC₉₀ ali 156 ndi 16.2 mu nkhani yoyamba ndipo 78 ndi 8.1 pa nkhani yachiwiri.

Pharmacokinetics

Mukamatenga Avelox mkati, moxifloxacin imagwira mwachangu kwambiri komanso pafupifupi kwathunthu. Mtheradi wake bioavailability pafupifupi 91%. Zatsimikiziridwa kuti pharmacokinetics ya chinthu ichi limodzi ndi mlingo umodzi wa 50-1200 mg, komanso mlingo wa Avelox patsiku lililonse la 600 mg kwa masiku 10, ndi liniya. Boma lofanana limakhazikitsidwa mkati mwa masiku atatu.

Pambuyo pa mlingo umodzi wa 400 mg wa Avelox, kuchuluka kwambiri m'magazi kumatheka ndi maola a 0 ndi 0,5 ndipo ndi 3.1 mg / l. Ndi pakamwa 400 mg wa mankhwala kamodzi patsiku, pazoyenera komanso zosafunikira kwenikweni za zinthu zomwe zili m'magazi ndi 3.2 mg / L ndi 0,6 mg / L, motsatana. Pamene moxifloxacin alowa mkatikati ndi chakudya, pamakhala chiwonjezeko chochepa kwambiri chazaka zofika nthawi yayitali kwambiri (pafupifupi maola 2) ndi kuchepa kochepa kwambiri kwa ndende yayikulu (pafupifupi 16%). Poterepa, nthawi yovomerezeka imakhalabe yosasinthika. Komabe, izi sizikhala ndi tanthauzo lililonse m'chipatala, chifukwa chake Avelox ndi yovomerezeka kugwiritsa ntchito mosasamala kanthu za chakudya.

Pambuyo kulowetsedwa kamodzi kwa Avelox pa mlingo wa 400 mg kwa ola limodzi, kuchuluka kwakukulu kwa chinthu kumafika kumapeto kwa kulowetsedwa ndipo kuli pafupifupi 4.1 mg / l, yomwe ikufanana ndi kuwonjezeka kwa pafupifupi 26% poyerekeza ndi phindu la paramuyi pakulamula kwa moxifloxacin.

Kuwonetsedwa kwa moxifloxacin, komwe kumatsimikiziridwa ndi chizindikiro cha AUC, kumapitirira pang'ono poyerekeza ndi kuyamwa kwa moxifloxacin. Mtheradi bioavailability pafupifupi 91%. Pambuyo mobwerezabwereza kulowetsedwa kwa Avelox pa mlingo wa 400 mg wokhazikika 1 ola limodzi patsiku, kuchuluka kwakukulu komanso kosachepera moxifloxacin m'magazi kumasiyana mulingo wa 4.1-5.9 mg / l ndi 0.43-0.84 mg / l, motsatana. Chiyero chokhazikika cha 4.4 mg / L chimakwaniritsidwa kumapeto kwa kulowetsedwa.

Mankhwalawa amagawidwa mwachangu mu ziwalo ndi minyewa. Mlingo wake womangidwa kumapuloteni amwazi (makamaka albin) uli pafupifupi 45%. Kuchuluka kwa magawa kumafika pafupifupi 2 l / kg.

Kuzungulira kwazikulu kwa moxifloxacin, ochulukitsa omwe ali m'madzi am'magazi, amalembedwa mu insulin (zotupa zamkati pakhungu), zotupa zam'mapapu (kuphatikizapo alveolar macrophages ndi epithelial fluid), ma polyps amphuno ndi zolakwika (ethmoid ndi maxillary sinuses). Mu malovu ndi zamadzimadzi am'mimba, gawo logwira ntchito la Avelox limatsimikizika mu mawonekedwe ake aulere (popanda kumangiriza mapuloteni) komanso mozama kwambiri kuposa plasma yamagazi. Komanso, moxifloxacin wapamwamba kwambiri amapezeka mwa ziwalo zoberekera wamkazi, zotumphukira ndi ziwalo zam'mimba.

Moxifloxacin amatenga nawo mbali pazochita ziwiri za gawo limodzi ndipo amuchotsa mthupi ndi mkodzo komanso ndowe. Kuphatikiza apo, imapezeka onse osasinthika komanso mawonekedwe a sulfo complements (M1) ndi glucuronides (M2), omwe alibe pharmacological.

Mankhwalawa sakukhudzidwa ndi michere ya microsomical chifukwa cha kukhudzana ndi microsomal system ya cytochrome P₄₅₀. Kuzama kwa plasma kwa M1 ndi M2 metabolites ndi kocheperako poyerekeza ndi kwa kholo. Zotsatira za kafukufuku wamtsogolo zimawonetsa kuti palibe zoyipa zilizonse za ma metabolites awa pa thupi molingana ndi kulekerera ndi chitetezo chawo.

Hafu ya moyo wa moxifloxacin pafupifupi maola 12. Pafupifupi, chilolezo chokwanira pambuyo pa kutumikiridwa kwa mankhwala mu 400 mg ndi 179-246 l / min. Chilolezo cha renal chimafika 24-53 ml / mphindi. Izi zimatsimikizira kusinthasintha kwa chinthu.

Kuchuluka kwa moxifloxacin ndi gawo 2 metabolites pafupifupi 96-98%, zomwe zimatsimikizira kusowa kwa oxidative metabolism. Pafupifupi 22% ya mlingo umodzi wa Avelox (400 mg) umachotsedwa mu mkodzo, ndipo pafupifupi 26% ndi ndowe.

Mukamaphunzira pharmacokinetics a moxifloxacin mwa odwala amphongo ndi amuna, AUC ndi kutsika kwakukulu kumasiyana pafupifupi 33%. Kuyamwa kwa chinthu sikukutengera jenda. Kusiyana kwa AUC komanso ndende yayitali ndizotheka kwambiri chifukwa cha kusiyana kwa kulemera kwa thupi, osati jenda, ndipo kulibe tanthauzo lililonse lazachipatala.

Kusiyana kwakukulu mu pharmacokinetics ya moxifloxacin mwa odwala azaka zosiyanasiyana komanso amitundu yosiyanasiyana sikunadziwike. Ma pharmacokinetics a moxifloxacin mwa ana pakadali pano samadziwika bwino.

Odwala omwe amakhala akudwala kwakanthawi kwamitsempha yamafupa, kapena odwala hemodialysis, komanso odwala omwe ali ndi vuto la impso (kuphatikizapo odwala CC ochepera 30 ml / min / 1.73 m 2), kusintha kwakukulu mu pharmacokinetics a moxifloxacin sanazindikire. Kusiyanitsa kwakukulu mu kuchuluka kwa moxifloxacin mwa odwala omwe ali ndi vuto la chiwindi (makalasi A ndi B malinga ndi kukula kwa Mwana-Pugh) poyerekeza ndi odwala omwe ali ndi chiwindi chokwanira komanso omwe ali ndiumoyo wathanzi palinso ena.

Zizindikiro zogwiritsidwa ntchito

Malinga ndi malangizo, Avelox 400 mg imasankhidwa kuti:

Njira zopatsirana zam'mapapo ndi ziwalo za ENT,
Matenda a intraabdominal ndi urogenital,
Matenda opatsirana a minofu yofewa ndi khungu.

Ntchito ya Avelox imawonetsedwa pokhudzana ndi mitundu yamagetsi yama gram-positive ndi gram-negative, mabakiteriya osagwirizana ndi mankhwala a beta-lactam ndi macrolide, mabakiteriya osagwirizana ndi asidi komanso mitundu ya michere, komanso mabakiteriya a anaerobic omwe amakana mankhwala.

Contraindication

Malangizo a Avelox akuwonetsa kuti kugwiritsidwa ntchito kwake ndikosavomerezeka mu matenda monga pseudomembranous colitis ndi kulephera kwambiri kwaimpso. Sizoletsedwa kumwa mapiritsi a amayi apakati komanso oyamwa, ana osaposa zaka 18 ndi anthu omwe ali ndi vuto lililonse pazamankhwala. Kusamala makamaka ndikofunikira popereka mankhwala kwa odwala omwe ali ndi matenda amitsempha yamafupa, ndikuwonetsa kuopsa kogwidwa. Matenda monga kulephera kwa chiwindi, pachimake myocardial ischemia, bradycardia, hypokalemia ndi chifukwa chosamalitsa poika Aveloks.

Malangizo ogwiritsa ntchito Avelox: njira ndi mlingo

Ma Avelok akhoza kutengedwa nthawi iliyonse masana, mosasamala kanthu za kudya. Mapiritsiwo amezedwa, popeza kukhulupirika kwa chigoba chake sikungawonongeke. Hafu ya moyo wa mankhwalawa ndi yayitali, motero ndikokwanira kumwa mankhwalawa kamodzi patsiku.

Mlingo wa tsiku ndi tsiku wa Avelox ndi 400 mg. Pambuyo pakumwa pakamwa, mankhwalawa amamwetsa msanga komanso pafupifupi. Mulingo wokwanira wa mankhwalawa m'magazi atagwiritsidwa ntchito kamodzi amawonedwa pambuyo pa maola 0.5-4 kuyambira nthawi ya makonzedwe. Kukwaniritsa khola la plasma moxifloxacin kumachitika pambuyo masiku atatu ogwiritsidwa ntchito pafupipafupi.

Mankhwala othandizira kulowetsedwa kumachitika kumayambiriro kwa chithandizo ndikupitilira kwa wodwalayo kugwiritsa ntchito Avelox pamapiritsi, kapena amagwiritsidwa ntchito mpaka kuchira.

Kutengera ndi matendawa, kutalika kwa mankhwalawa ndi masiku 7-10.

Zotsatira zoyipa

Zotsatira zoyipa zimachitika kawirikawiri, motsatira malamulo a dosing. Avelox ikhoza kuyambitsa zotsatirazi zotsatirazi:

Kusanza, kusanza, kupweteka kwam'mimba, vuto la kukoma, stomatitis, kutsekula m'mimba,
Kuchuluka kwa kugunda kwa mtima, kupweteka pachifuwa, palpitation, kuthamanga kwa magazi,
Chizungulire, kusowa tulo, kukhumudwa, nkhawa, kusokonezeka, kufooka,
Kupweteka kumbuyo, kupweteka kwamisempha ndi mafupa, tendovaginitis, kupindika kwa tendon,
Kuyabwa, zotupa pakhungu,
Hyperglycemia, hyperlipidemia, hyperuricemia,
General malaise, kutupa.

Bongo

Pakadali pano, pali zambiri zochepa zokhudzana ndi bongo wa Avelox. Pogwiritsa ntchito kamodzi kamodzi mankhwala osokoneza bongo mpaka 1200 mg kapena atamwa mankhwala osapitirira 600 mg, palibe mavuto omwe adalembedwa masiku 10.

Pankhani ya mankhwala osokoneza bongo, ndikofunikira kuphunzira mosamala chithunzi cha momwe wodwalayo alili komanso kupereka mankhwala othandizira osakanikirana ndi kuwunika kwa ECG.

Kudya kwa activated kaboni pambuyo pakamwa makonzedwe a moxifloxacin mthupi nthawi zambiri amathandiza kupewa kupewetsa kukhudzana kwatsatanetsatane ndi mankhwalawa ngati munthu ali ndi mankhwala ochuluka.

Malangizo apadera

Ngati kupweteka kumalumikizana kapena tendon mukamamwa Avelox, mankhwalawa amalepheretsa kupindika kwa tendon.

Odwala omwe ali ndi khunyu, Avelox amatha kuyambitsa kukomoka.

Ndi kukula kwa m'mimba kwambiri mutamwa Avelox, ndiye kuti kuthetsedwa.

Kudya kwa ma antacid ndi ma enterosorbents, komanso mankhwala omwe amaphatikiza chitsulo, zotayidwa ndi magnesium ziyenera kuchitika nthawi zosiyanasiyana ndi Avelox, kusiyana kuyenera kukhala kosachepera maola 4.

Avelox sagwiritsidwa ntchito pochiza ana.

Kukopa pa kuthekera koyendetsa magalimoto ndi njira zowerengeka

Kugwiritsa ntchito Avelox kumatha kudzetsa mavuto kwa odwala akamayendetsa magalimoto ndikuchita zina mwa njira zoopsa zomwe zimafuna kuwonjezereka kwa zochitika zama psychomotor, zomwe zimachitika chifukwa cha zovuta zina zamankhwala.

Mimba komanso kuyamwa

Chitetezo cha kayendetsedwe ka moxifloxacin pa nthawi ya pakati sichinakhazikitsidwe, chifukwa chake kugwiritsidwa ntchito kumatsutsana. Zovuta za kusinthika kophatikizika kwa ana omwe adamwa ma quinolones ena amadziwika, koma izi sizinapezeke mwa mwana wosabadwayo panthawi ya chithandizo ndi amayi apakati a Avelox.

Kafukufuku wazinyama atsimikizira kuopsa kwa kubereka kwa moxifloxacin. Kwa anthu, chiopsezo cha Avelox sichimamveka bwino.

Moxifloxacin, monga mitundu ina ya quinolones, imayambitsa kuwonongeka kwa ziwalo zazikuluzikulu zamagulu akulu mwa nyama zobadwa kale. Kafukufuku wamtsogolo akuwonetsa kuti moxifloxacin, pazinthu zochepa, amadutsa mkaka wa m'mawere. Zambiri pazogwiritsidwa ntchito kwa odwala panthawi ya mkaka wa m`mawere sizikupezeka, chifukwa chake, kugwiritsa ntchito kwake pakamayamwa kumatsutsana.

Kutulutsa mawonekedwe, kapangidwe kake ndi ma CD

Mapiritsi okhala ndi Avelox:

Piritsi 1 ili ndi moxifloxacin (mu mawonekedwe a hydrochloride) - 400 mg
mu bokosi 1 chithuza cha 5 kapena 7 ma PC, kapena mu bokosi 2 matuza a ma 5 ma PC.

Njira yothetsera kulowetsedwa kwa Avelox:

Botolo 1 lili ndi moxifloxacin (mu mawonekedwe a hydrochloride) - 400 mg
Zosakaniza zina: sodium chloride, sodium hydroxide, hydrochloric acid, madzi d / ndi.
250 ml -1 botolo m'bokosi.

Njira yothetsera kulowetsedwa kwa Avelox:

Paketi 1 imakhala ndi moxifloxacin (mu mawonekedwe a hydrochloride) - 400 mg
Zosakaniza zina: sodium chloride, sodium hydroxide, hydrochloric acid, madzi d / ndi.
250 ml - matumba a polyolefin (1) - matumba apulasitiki okhala ndi foil (12) m'bokosi.

Zotsatira za pharmacological

Moxifloxacin ndi bactericidal antibacterial mankhwala omwe ali ndi mawonekedwe osiyanasiyana ochita mndandanda wa fluoroquinolone. Mphamvu ya bactericidal ya mankhwalawa imachitika chifukwa cha kuletsa kwa bakiteriya topoisomerases II ndi IV, komwe kumayambitsa kusokonezeka kwa biosynthesis ya DNA ya selo laling'ono ndipo, chifukwa chake, ku kufa kwa maselo okhala ndi ma cell ochepa. Zozungulira zochepa za bactericidal za mankhwala nthawi zambiri zimakhala zofanana ndi kuchepa kwake kwakanthawi.

Njira zomwe zimatsogolera pakupanga kukana kwa penicillin, cephalosporins, aminoglycosides, macrolides ndi ma tetracyclines saphwanya antibacterial zochita za moxifloxacin.Palibe kutsutsana kwapakati pa magulu awa a antibacterial mankhwala ndi moxifloxacin. Pakadali pano, sipanakhalepo zochitika za kukana kwa plasmid. The pafupipafupi kukula kwa kukana ndi ochepa kwambiri (10 7 - 10 10). Kukana kwa Moxifloxacin kumayamba pang'onopang'ono kudzera pakusintha kambiri. Kuwonetsedwa mobwerezabwereza kwa moxifloxacin kuzinthu zamagetsi zomwe zimakhala m'munsi mwa zochepa zoletsa ndende (MIC) zimayendera limodzi ndi kuwonjezeka pang'ono kwa MIC. Milandu yotsutsana ndi quinolones imadziwika. Komabe, tizilombo tating'onoting'ono tokhala ndi gramu komanso anaerobic osagwirizana ndi ma quinolones ena timawaganizirabe moxifloxacin.

In vitro moxifloxacin imagwira ntchito motsutsana ndi michere yama gram-hasi komanso gram-virus, anaerobes, mabakiteriya osagwira asidi komanso mitundu ya atypical, monga Mycoplasma, Chlamidia, Legionella, komanso mabakiteriya osagonjetsedwa ndi ß-lactam ndi maantifid.

Kodi chimathandiza Avelox ndi chiyani?

Zizindikiro zazikulu pakusankhidwa kwa Avelox ndi mikhalidwe / matenda:

Njira zopatsirana zam'mapapo ndi ziwalo za ENT,
Matenda a intraabdominal ndi urogenital,
Matenda opatsirana a minofu yofewa ndi khungu.

Mimba

Chitetezo pakugwiritsa ntchito moxifloxacin pa nthawi ya pakati sichinakhazikitsidwe ndipo kugwiritsidwa ntchito kwake ndikotsutsana. Milandu yakuwonongeka kwaphatikizidwe kwa ana omwe amalandila ma quinolones ena amafotokozedwa, komabe, kuwonekera kwa izi mwa mwana wosabadwayo (akagwiritsidwa ntchito ndi amayi panthawi yapakati) sizinanenedwe.

Kafukufuku wazinyama awonetsa kawopsedwe kabala. Chiwopsezo chomwe chilipo kwa anthu sichikudziwika.

Monga mitundu ina ya quinolones, moxifloxacin imapangitsa kuwonongeka kwa malowedwe akulu azinyama zazikulu. Kafukufuku wofufuza wapeza kuti moxifloxacin wocheperako amamuyamwa mkaka wa m'mawere. Zomwe zimagwiritsidwa ntchito mwa azimayi pa nthawi yotsala sizikupezeka. Chifukwa chake, kuperekedwa kwa moxifloxacin pa yoyamwitsa kumatsutsana.

Kuyanjana kwa mankhwala osokoneza bongo

Kuphatikizidwa kwa moxifloxacin ndi probenecid (kusowa kwa mgwirizano wamphamvu ndi gawo la Avelox kwatsimikiziridwa), atenolol, morphine, ranitidine, digoxin, itraconazole, calcium yokhala ndi zina, glibenclamide, theophylline, kulera kwapakamwa, cyclosporin sikofunikira.

Ndi kugwiritsidwa ntchito kophatikizana kwa Avelox ndi mankhwala omwe amakhudza kutalika kwa gawo la QT, zotsatira zowonjezera pakukweza nthawi ya QT zitha kuonedwa. Ndi kuphatikiza kwa moxifloxacin ndi mankhwala ofanana, chiopsezo chotukuka kwamitsempha yama cell, kuphatikizapo polymorphic ventricular tachycardia (torsade de pointes), ikuchulukitsidwa.

Kuphatikiza kwa moxifloxacin ndi mankhwala otsatirawa omwe amakhudza kutalika kwa nthawi ya QT ndi otsutsana:

antihistamines (misolastine, astemizole, terfenadine),
mankhwala a antiarrhythmic a class IA (disopyramides, hydroquinidine, quinidine, etc.),
mankhwala a antiarrhythmic a kalasi III (ibutilide, amiodarone, dofetilide, sotalol, etc.),
antimicrobials antimalarials, makamaka halofantrine, sparfloxacin, pentamidine, erythromycin (mtsempha wamkati),
mankhwala antidepressants,
antipsychotic (suloprid, phenothiazine, haloperidol, sertindole, pimozide, etc.),
diphemanil ina, chisapride, bepridil, vincamine (mtsempha wamkati).

Kukhazikika kwa munthawi yomweyo kwa Avelox ndi ma multivitamini, michere ndi maantacidin kungapangitse kuti mupewe kufooka kwa moxifloxacin chifukwa cha mapangidwe a chelate complexes omwe ali mbali ya mankhwalawa. Zotsatira zake, kuchuluka kwa moxifloxacin m'madzi am'magazi kumatha kutsika kwambiri kuposa koyenera. Chifukwa chake, mankhwala ochepetsa mphamvu ya kachilomboka (monga. m`kamwa makonzedwe a Avelox.

Ndi kuphatikiza kwa Avelox ndi warfarin, nthawi ya prothrombin ndi magawo ena a magazi a magazi amakhalabe osasinthika. Odwala omwe amathandizidwa ndi anticoagulants osakaniza maantibayotiki, milandu yowonjezereka ya anticoagulant ya mankhwala osokoneza bongo imawonedwa.

Zowopsa zimaphatikizira momwe wodwalayo aliri komanso zaka zake, komanso kukhalapo kwa matenda opatsirana omwe amayenda limodzi ndi njira zotupa. Ngakhale kuti kulumikizana kwa moxifloxacin ndi warfarin sikunatsimikizidwe mpaka pano, odwala omwe amathandizidwa ndi mankhwalawa amayenera kuwunika INR nthawi zonse, ndipo ngati kuli koyenera, achulukitse kapena kuchepetsa mlingo wa anticoagulants osadziwika.

Digoxin ndi moxifloxacin kwenikweni sizikhudza magawo a pharmacokinetic wina ndi mnzake. Ndi kukhazikitsidwa kwa Mlingo wobwereza wa Avelox, kuchuluka kwambiri kwa digoxin kumawonjezeka pafupifupi 30%. Pankhaniyi, kuchuluka kwapadera kwa digoxin ndi kufunika kwa malo omwe ali pansi pa pharmacokinetic pamapindikira "nthawi -" sizinasinthe.

Ndi munthawi yomweyo makonzedwe a moxifloxacin pa mlingo wa 400 mg ndikuyambitsa makala, dongosolo la bioavailability la Avelox limatsika ndi oposa 80% chifukwa choletsa kuyamwa kwake. Ngati bongo umagwiritsidwa ntchito, kugwiritsa ntchito kaboni yokhoma kumayambiriro kwa mayamwa kumalepheretsa kuwonekera kwina.

Zofanizira za Avelox pazomwe zimagwira ndi izi: Mankhwala Vigamox, Moximac, Moxin, Moxifloxacin, Moxifloxacin hydrochloride, Plevilox. Magulu omwewo a pharmacological amaphatikizapo: Abactal, Basigen, Gatispan, Geoflox, Zanocin, Xenaquin, Levoflox, Normax, Ofloxacin, Ciprofloxacin ndi ena.

Ndemanga za Aveloks

Ndemanga za Avelox yomwe idasiyidwa ndi akatswiri ndizosokoneza. Madokotala ena amaliona ngati mankhwala amphamvu komanso othandiza pamavuto omwe amathandiza kuthana ndi causative wothandizila wa matenda monga chlamydia, pyelonephritis, chimfine, SARS, ndi E. coli. Akatswiri ena akuti palibe zotsatira zabwino za chithandizo chamankhwala, koma amawona zovuta zingapo.

Malingaliro a odwala za Avelox nawonso ali osakanikirana. Anthu ambiri amatchula zotsatirapo zosasangalatsa monga kuperewera kwa chidwi ndi nseru. Komabe, odwala ambiri amawona kuti ndi mankhwala amphamvu a antibacterial.

Kupanga ndi mawonekedwe a kumasulidwa

Avelox imapezeka mu mapiritsi ndi njira yothetsera kulowetsedwa (osati jekeseni). Dziwani bwino za kapangidwe kake, malongosoledwe ake ndi mafotokozedwe achidule:

Wapinki, matte, oblong, wokutidwa ndi filimu.

Transparent chikasu chikasu.

The kuchuluka kwa moxifloxacin, mg

400 pa botolo limodzi

Titanium dioksidi, microcrystalline cellulose, macrogol, croscarmellose sodium, red iron oxide, lactose monohydrate, hypromellose

Madzi, sodium chloride, hydrochloric acid, sodium hydroxide solution.

Matumba a ma PC 5 kapena 7., mapaketi a matuza 1 kapena 2.

250 ml Mbale kapena zotengera.

Mlingo ndi makonzedwe

Madokotala nthawi zambiri amapereka Avelox chifukwa cha angina, abscess, chibayo, chifukwa cha antibacterial, mankhwalawa amapha ma causative othandizira matenda ndikuthandizira kutupa. Njira ntchito, Mlingo regimen ndi kutalika kwa njira ya mankhwala zimadalira mtundu, zovuta matenda ndi mawonekedwe a mankhwalawa. Mapiritsi amatengedwa pakamwa, yankho limakhala la makolo, mwanjira ya infusions.

Avelox mapiritsi amatengedwa pakamwa pa 400 mg 1 nthawi / tsiku. Mapiritsiwo samatafunidwa, kutsukidwa ndimadzi, osasamala chakudyacho. Mukakalamba, mlingo sasintha. Kutalika kwa chithandizo kumatengera matendawa:

Njira ya mankhwala masiku

Kuchulukitsa kwa matenda osakhazikika

Chibayo chomwe chimapezeka m'magulu atatha mapangidwe a Avelox

Kulowetsedwa njira

Kuti mugwiritse ntchito intravenous, yankho la dzina lomweli mu 400 mg kamodzi / tsiku limapangidwa. Mankhwala osokoneza bongo amakhala mpaka masiku 21. Ndi chibayo chopezeka m'deralo, mankhwalawa amatenga masiku 7 mpaka 14, ndi matenda ovuta - masiku 7 mpaka 21, omwe ali ndi matenda am'mimba - masiku 5-14. Kwa okalamba ndi odwala omwe ali ndi vuto la chiwindi, Mlingo wakewo sasintha.

Njira yothetsera vutoli imaperekedwa kwa ola limodzi. Mankhwalawa angagwiritsidwe ntchito ndi dilution ndi madzi, yankho la Ringer, sodium chloride, dextrose kapena xylitol. Yankho lomveka lokha lomwe limayambitsidwa popanda turbidity, sediment. Pambuyo pakuthira ndi zosungunulira, mankhwalawa amakhala okhazikika tsiku lonse, malinga ngati amasungidwa kutentha.

Pa nthawi yoyembekezera

Chitetezo pakugwiritsa ntchito moxifloxacin pa nthawi ya pakati sichinakhazikitsidwe, chifukwa chake kugwiritsidwa ntchito kumatsutsana. Kafukufuku mu makoswe adawonetsa kawopsedwe akubereka. Nyama, Moxifloxacin amachititsa kuwonongeka kwa malowedwe akulu, ophatikizidwa mkaka wa m'mawere, kotero chithandizo cha bere chimatsutsana.

Muubwana

Avelox sangathe kugwiritsidwa ntchito muubwana komanso unyamata wazaka 18. Izi zimakhudzana ndi chiwopsezo cha kusokonekera magwiridwe antchito ndi ma cartilage. Kuwonetsa kwambiri maantibayotiki kungayambitse poizoni, kukula kwa totupa tambiri, kukhumudwa komanso kupsinjika kwa mtima wamanjenje. Izi ndizowopsa kuubwana komanso pakati pa ana asukulu.

Avelox ndi mowa

Kuti mupewe chiwopsezo cha zovuta za chiwindi, kwa nthawi yayitali ya Avelox, muyenera kukana kumwa zakumwa zoledzeretsa kapena mankhwala osokoneza bongo. Mowa umasokoneza ziwalo, zimayambitsa chidakwa komanso kuledzera. Ethanol amachepetsa mphamvu ya mankhwalawa, zomwe zimayambitsa zovuta zoyipa. Mutha kuyambiranso kumwa patatha mwezi umodzi kutha kwa chithandizo.

Migwirizano yogulitsa ndikusunga

Avelox amagulitsidwa ndi mankhwala, amasungidwa pamatenthedwe mpaka madigiri 25 a mapiritsi ndi madigiri 15-30 kuti athandizidwe. Alumali moyo wa mapiritsi ndi Mbale za yankho ndi zaka zisanu, yankho lili mumbale ndi zaka zitatu.

Majini okhala ndi zinthu zomwezo ndipo amagwirizira ndi chinthu china, koma mwanjira yomweyo, amatchulidwa ku Aveloks analogues. Mankhwala a antimicrobial:

Aquamox - yankho lochokera moxifloxacin,
Moxifluor ndi mtundu wakale wa mankhwalawo womwe ukufunsidwa,
Megaflox - mapiritsi okhala ndi mankhwala omwewo
Hainemoks - kukonza piritsi, kuwongolera mwachindunji,
Moxifloxacin ndiye wokonda kwambiri mankhwala.

Malangizo ogwiritsira ntchito (Njira ndi Mlingo)

Mapiritsi amatengedwa popanda kutafuna kapena kugawanitsa, mosasamala kanthu ndi chakudyacho.

Malinga ndi malangizo a Avelox 400 mg, kwa akulu, Mlingo wa tsiku ndi tsiku ndi piritsi limodzi kapena 400 mg ya antiotic.

Kutalika kwa magwiridwe antchito amayenera kutsimikiziridwa ndi adotolo, kutengera kuopsa kwa matendawa, kugwira ntchito kwake komanso chidwi cha wodwalayo.

Monga lamulo, kumayambiriro kwa mankhwala, mankhwala amawayikidwa jakisoni, ndiye, atatha kusintha kwa mapiritsi, mapiritsi amatha kuyikidwa.

Ndi zochulukitsa aakulubronchitis Njira ya mankhwala ndi mankhwala masiku 5. At chibayo - kuyambira 7 (jakisoni) mpaka masiku 10.

At sinusitis pachimake ndi matenda osavuta a pakhungu ndi zimakhala, nthawi yopereka maantibayotiki ndi sabata limodzi.

Ndi matenda osavuta a ziwalo zapakhosi, njira yochizira ndi milungu iwiri.

Pazovuta zovuta pakhungu ndi kapangidwe kake pansi pa khungu, mankhwalawa amachitika motsatizana ndipo amatenga masiku 5 mpaka milungu iwiri.

Mwa anthu omwe ali ndi vuto la impso ndi kwa chiwindi, okalamba, komanso m'magulu osiyanasiyana, kusintha kwa mankhwalawa sikuchitika.

Malangizo ogwiritsa ntchito Avelox jakisoni

Gwiritsani ntchito yankho lomveka bwino, popanda kuwongolera kapena kutentha.

Mankhwalawa amathandizidwa pakhungu kwa nthawi yayitali, kwa mphindi 60, osachepera popanda kuchepetsedwa. Nthawi zambiri mankhwalawa amaphatikizidwa T adapter ndi madzi a jakisoni sodium mankhwala enaake(0.9% kapena 1M), yankho dextrose (5%, 10%, 40%), yankho xylitol 20%, yankho la ringer. Osakaniza okonzeka akhoza kusungidwa kutentha firiji kwa maola 24.

Mu syringe kapena dontho lomwelo, othandizira ena saphatikizidwa.

Kuchita

Amakhala bwino ndi atenolol, theophylline, calcium kukonzekera, ranitidine, pakamwa kulera, intraconazole, morphine, glibenclamide, digoxin, warfarin, probenecid.

Komabe, akaphatikizidwa anticoagulants iyenera kuganiziridwa ndi kusunthidwa nthawi ndi nthawi INRSinthani mosamala mlingo wa mankhwalawo.

Akaphatikizidwa ndi Maantacid okhala ndi mavitamini ndipo mchere umapangidwa chelate ma polar okhala ndi ma polyvalent cations, kuchuluka kwa maantibayotiki m'magazi kumachepa. Pachifukwa ichi, kupatula kwa maola anayi pakati pa kumwa mankhwalawa kuyenera kuonedwa.

Ngati muphatikiza mankhwalawo ndi mpweya woyambitsa kapena ena ammayankhoma, ndiye bioavailability wa mankhwalawa amachepetsedwa (pafupifupi 80%). Ndi makonzedwe amkati, chiwerengerochi chimafika 20%.

Njira yothetsera kulowetsedwa sikuyenera kuperekedwa ndi 10% ndi 20% sodium chloride, sodium hydrogencarbonate 4.2% ndi 8.4%.

Zolemba za Avelok

Ma fanizo apafupi kwambiri a Avelox: Moxifloxacin-Farmex, Moxifloxacin, Moxifluor, Moflox, Moxifloxacin-Kredofarm, Maxicin, Moxifluor 400, Moxin, Tevalox, Mofloxin Lupine.