Mndandanda wa mapiritsi a Rosucard
Kufanizira kwa rosucard ya mankhwala, kusinthana kwa mphamvu ya thupi, kukonzekera komwe kumakhala ndi chinthu chimodzi kapena zingapo zofanana zimaperekedwa. Mukamasankha mawu ofananitsa, osangoganizira mtengo wawo, komanso dziko lakapangidwe ndi mbiri ya wopanga.
- Kufotokozera za mankhwalawa
- Mndandanda wazofananira ndi mitengo
- Ndemanga
- Malangizo ovomerezeka ogwiritsa ntchito
Kufotokozera za mankhwalawa
Rosucard - Mankhwala a hypolipidemic a m'gulu la ma statins. Kusankha mpikisano wosankha wa HMG-CoA reductase, enzyme yomwe imatembenuza HMG-CoA kukhala mevalonate, woyang'anira cholesterol (Ch).
Kuchulukitsa kuchuluka kwa zolandila za LDL pamtunda wa hepatocytes, zomwe zimapangitsa kuti pakhale zambiri zomwe zimapangitsa kuti LDL ichitike, kulepheretsa kaphatikizidwe ka VLDL, kuchepetsa kuthamanga kwa LDL ndi VLDL. Kuchepetsa kuchuluka kwa LDL-C, HDL cholesterol-non-lipoproteins (HDL-non-HDL), HDL-V, cholesterol okwanira, TG, TG-VLDL, apolipoprotein B (ApoV), kumachepetsa kuchuluka kwa LDL-C / LDL-C, kwathunthu HDL-C, Chs-not HDL / Cs-HDL, ApoB / apolipoprotein A-1 (ApoA-1), imakulitsa kuchuluka kwa Cs-HDL ndi ApoA-1.
Kuchulukitsa kwa lipid kumachitika mwachindunji molingana ndi kuchuluka kwa mlingo womwe umaperekedwa. Mankhwala othandizira amawonekera pakatha sabata limodzi atangoyamba kumene chithandizo, pakatha masabata awiri kufika 90% pazowonjezereka, amafika pakadutsa masabata anayi kenako amakhala osasintha.
Tebulo 1. Mphamvu yodalira Mlingo wa odwala omwe ali ndi hypercholesterolemia yoyamba (mtundu IIa ndi IIb malinga ndi gulu la Fredrickson) (kusintha kosinthidwa kwapakati poyerekeza ndi mtengo woyambira)
| Mlingo | Chiwerengero cha odwala | HS-LDL | Chonse | HS-HDL | |
| Malo | 13 | -7 | -5 | 3 | |
| 10 mg | 17 | -52 | -36 | 14 | |
| 20 mg | 17 | -55 | -40 | 8 | |
| 40 mg | 18 | -63 | -46 | 10 | |
| Mlingo | Chiwerengero cha odwala | TG | Xc- osakhala HDL | Apo v | Apo AI |
| Malo | 13 | -3 | -7 | -3 | 0 |
| 10 mg | 17 | -10 | -48 | -42 | 4 |
| 20 mg | 17 | -23 | -51 | -46 | 5 |
| 40 mg | 18 | -28 | -60 | -54 | 0 |
Tebulo 2. Kutengera kudalira kwa odwala omwe ali ndi hypertriglyceridemia (mtundu IIb ndi IV malinga ndi gulu la Fredrickson) (kusintha kwapakati poyerekeza ndi mtengo woyambira)
| Mlingo | Chiwerengero cha odwala | TG | HS-LDL | Chonse | |
| Malo | 26 | 1 | 5 | 1 | |
| 10 mg | 23 | -37 | -45 | -40 | |
| 20 mg | 27 | -37 | -31 | -34 | |
| 40 mg | 25 | -43 | -43 | -40 | |
| Mlingo | Chiwerengero cha odwala | HS-HDL | Xc- osakhala HDL | Xc- VLDL | TG- VLDL |
| Malo | 26 | -3 | 2 | 2 | 6 |
| 10 mg | 23 | 8 | -49 | -48 | -39 |
| 20 mg | 27 | 22 | -43 | -49 | -40 |
| 40 mg | 25 | 17 | -51 | -56 | -48 |
Mphamvu zamankhwala
Kugwiritsa ntchito kwa odwala achikulire omwe ali ndi hypercholesterolemia wokhala ndi kapena wopanda hypertriglyceridemia, mosaganizira mtundu, jenda kapena msinkhu, incl. Odwala matenda a shuga ndi matenda am'magazi. Mu 80% ya odwala omwe ali ndi mtundu wa IIa ndi IIb hypercholesterolemia (malinga ndi gulu la Fredrickson) ndi kuchuluka koyambirira kwa LDL-C pafupifupi 4.8 mmol / L, pamene akumwa mankhwalawa pa 10 mg, kuchuluka kwa LDL-C kumafika kosakwana 3 mmol / L.
Odwala omwe ali ndi heterozygous Famer hypercholesterolemia akulandira rosuvastatin pa mlingo wa 20-80 mg / tsiku, kusintha kwakukulu kwa lipid mbiri. Pambuyo titration kwa tsiku lililonse 40 mg (12 milungu mankhwala), kuchepa kwa ndende ya LDL-C ndi 53% anati. Mu 33% ya odwala, kuchuluka kwa LDL-C kosakwana 3 mmol / L kunakwaniritsidwa.
Odwala omwe ali ndi homozygous Famer hypercholesterolemia akulandira rosuvastatin pa 20 mg ndi 40 mg, kutsika kwapakati pa LDL-C kunali 22%.
Odwala omwe ali ndi hypertriglyceridemia ndi ndende yoyambirira ya TG kuchokera ku 273 mg / dl mpaka 817 mg / dl, kulandira rosuvastatin mu Mlingo wa 5 mg mpaka 40 mg 1 nthawi / tsiku kwa masabata 6, kuchuluka kwa TG m'magazi a magazi kunachepetsedwa (onani tebulo 2) )
Mphamvu yowonjezera imawonedwa limodzi ndi fenofibrate pokhudzana ndi kuchuluka kwa TG komanso nicotinic acid mu lipid kutsitsa Mlingo (woposa 1 g / tsiku) pokhudzana ndi kuchuluka kwa HDL-C.
Pakufufuza kwa METEOR, chithandizo cha rosuvastatin chinachepetsa kwambiri kupita patsogolo kwa makulidwe apamwamba a intima-media tata (TCIM) magawo 12 a chotupa cha carotid poyerekeza ndi placebo. Poyerekeza ndi zoyambira mu gulu la rosuvastatin, kuchepa kwa TCIM yokwanira ndi 0.0014 mm / chaka kudadziwika poyerekeza ndi chiwonetsero ichi ndi 0.0131 mm / chaka pagulu la placebo. Mpaka pano, ubale wolunjika pakati pa kuchepa kwa TCIM ndi kuchepa kwa chiwopsezo cha zochitika zam'mtima sizinawonetsedwe.
Zotsatira za kafukufuku wa JUPITER zidawonetsa kuti rosuvastatin adachepetsa kwambiri ngozi yokhala ndi mtima ndi kuchepetsedwa kwa chiwopsezo cha 44%. Kuchita bwino kwa mankhwalawa kunadziwika pambuyo pa miyezi 6 yoyambirira yogwiritsa ntchito mankhwalawa. Panali kuchepa kwakukulu kwa 48% mwa zotsimikizika zophatikizika, kuphatikiza kufa chifukwa cha mtima, kuponderezana ndi kuphwanya kwa chifuwa cha infrality, komanso kuchepa kwa 48% pangozi yakupha kapena yosavulala. Chiwerengero chakufa chatsika ndi 20% mgulu la rosuvastatin. Mbiri ya chitetezo kwa odwala omwe amatenga 20 mg rosuvastatin nthawi zambiri inali yofanana ndi mbiri yotetezeka yomwe ili mgulu la placebo.
Mndandanda wa mankhwala Rosucard
Analogue ndiotsika mtengo kuchokera ku ma ruble 529.
Wopanga: Biocom (Russia)
Kutulutsa Mafomu:
- Mapiritsi 10 mg, 30 ma PC., Mtengo kuchokera ku ma ruble 110
- Mapiritsi 20 mg, 30 ma PC., Mtengo kuchokera ku 186 rubles
Malangizo ogwiritsira ntchito
Atorvastatin ndi piritsi-mawonekedwe kumasulidwa kukonzekera anafuna kuchiza ndi kupewa matenda a mtima. Contraindified pa mimba, mkaka wa m`mawere ndi ana osaposa zaka 18.
Analogue ndiyotsika mtengo kuchokera ku ma ruble 161.
Wopanga: Dzuwa (Russia)
Kutulutsa Mafomu:
- Mapiritsi 10 mg, 30 ma PC., Mtengo kuchokera 478 ma ruble
- Mapiritsi 20 mg, ma PC 30, Mtengo kuchokera ku ma ruble 790
Malangizo ogwiritsira ntchito
Akorta ndi mankhwala opangidwa ku Russia omwe amapezeka mwanjira ya mapiritsi ndipo adapangidwira zochizira matenda amtima. Contraindified mu mimba ndi mkaka wa m`mawere. Pali zovuta zina.
Analogue ndiotsika mtengo kuchokera ku ma ruble 176.
Wopanga: AstraZeneca (UK)
Kutulutsa Mafomu:
- Mapiritsi 10 mg, 7 ma PC., Mtengo kuchokera 463 ma ruble
- Mapiritsi 20 mg, ma PC 30, Mtengo kuchokera ku ma ruble 790
Malangizo ogwiritsira ntchito
Krestor ndi mankhwala ochizira matenda a mtima. Monga ntchito yogwira, rosuvastatin wambiri 5 mg amagwiritsidwa ntchito. piritsi 1 limodzi. Pali contraindication ndi mavuto.
Analogue ndiyotsika mtengo kuchokera ku ma ruble a 180.
Wopanga: AJonior Richter (ku Hungary)
Kutulutsa Mafomu:
- Mapiritsi a 5 mg, ma PC 30, Mtengo kuchokera pa ma ruble a 459
- Mapiritsi 20 mg, ma PC 30, Mtengo kuchokera ku ma ruble 790
Malangizo ogwiritsira ntchito
Mertenil ndi mankhwala ochepetsa mphamvu ya lipid aku Hungary yozikidwa pa rosuvastatin. Kugulitsidwa m'makatoni 30 mapiritsi. Zizindikiro zazikulu zakusankhidwa kwake: hypercholesterolemia, hypertriglyceridemia (mtundu IV malinga ndi Fredrickson), komanso kupewa koyambilira kwa zovuta zazikulu zamtima (stroke, mtima, kusinthika kwa mtima).
Analogue ndiotsika mtengo kuchokera ku ma ruble 223.
Wopanga: Krka (Slovenia)
Kutulutsa Mafomu:
- Tab. tsa / obol. 5 mg, ma 30 ma PC., Mtengo kuchokera pa ma ruble 416
- Mapiritsi 20 mg, ma PC 30, Mtengo kuchokera ku ma ruble 790
Malangizo ogwiritsira ntchito
Roxera ndi mankhwala ochepetsa mphamvu ya lipid a ku Slovenia. Amapezeka mu mapiritsi okhala ndi rosuvastatin muyezo wa 5 mpaka 20 mg. Amagwiritsidwa ntchito kuti achulukitse cholesterol yambiri.
Analogue ndiotsika mtengo kuchokera ku ma ruble 371.
Wopanga: Belupo (Croatia)
Kutulutsa Mafomu:
- Mapiritsi 10 mg 14 ma PC., Mtengo kuchokera ku ma ruble 268
- Mapiritsi 20 mg, ma PC 30, Mtengo kuchokera ku ma ruble 790
Malangizo ogwiritsira ntchito
Rosistark ndi mankhwala a hypolipidemic a group la statins. Kuphatikiza molekyu ya rosuvastatin. Imachepetsa cholesterol ndi tizigawo ting'onoting'ono, amathetsa kusokonekera kwa endothelial. Ili ndi antiproliferative ndi antioxidant katundu. Amalembera hypercholesterolemia, kuchuluka kwa triglycerides m'magazi, kuti athetse kupitirira kwa atherosulinosis ndikuchepetsa ngozi ya mtima. Zinthu zonse zomwe zimakhala ndi rosuvastatin zimagwiritsidwa ntchito nthawi iliyonse masana, mosasamala kanthu za kudya. Mtheradi contraindication ntchito kwambiri matenda a impso ndi chiwindi, myopathy, akazi a mibadwo yobala popanda kulera. Zotsatira zoyipa zoyipa kwambiri, kudzimbidwa, kupweteka mutu, ndi kuwawa kwa minofu.
Analogue ndiotsika mtengo kuchokera ku ma ruble 305.
Wopanga: Aegis (Hungary)
Kutulutsa Mafomu:
- Tab. tsa / obol. 5 mg, 28 ma PC., Mtengo kuchokera pa ma ruble 334
- Tab. tsa / obol. 10 mg, 28 ma PC., Mtengo kuchokera ku ma ruble 450
Malangizo ogwiritsira ntchito
Rosulip ndi rosuvastatin wina wa gulu la statin. Zimapangidwa, monga Rosart, komanso ma rosuvastatins onse omwe alipo, momwe amapangira mapiritsi. Ikatengedwa, imatsitsa kuchuluka kwa cholesterol, otsika komanso otsika kwambiri a lipoproteins (LDL, VLDL), triglycerides, ndikuchulukitsa lipoproteins yapamwamba kwambiri, yomwe imateteza thupi laumunthu ku zovuta zamavuto am'kati ndi ubongo. Amasintha magazi, amateteza mapangidwe a atherosulinotic plaques. Zizindikiro zothandizira, Mlingo ndi makina othandizira, zotsutsana ndi zotsatira zoyipa ndizofanana ndendende ndi Rosartark, popeza mankhwalawa ali ndi rosuvastatin.
Katundu wa mankhwala osokoneza bongo
Kuti musankhe fanizo la Rosucard, muyenera kudziwa kuti ili ndi katundu wanji. Mankhwala amapezeka mu mapiritsi 10 mg. Mankhwalawa amachepetsa kuchuluka kwa lipoproteins otsika, kapena "oyipa" cholesterol, ndikuwonjezera kuchuluka kwa lipoproteins yapamwamba. Chofunikira chachikulu ndi rosuvastatin.
Amagwiritsidwa ntchito atherosulinosis, hyperlipidemia, hypercholesterolemia. Itha kugwiritsidwa ntchito ngati prophylactic motsutsana ndi matenda amtima.
Ndikofunikira kuphatikiza kumwa mapiritsi ndi zakudya zochepetsa lipid, ndiye kuti, zakudya, zomwe kuchuluka kwa mafuta kumachepetsedwa.
Njira ya mankhwala ndi mankhwalawa iyenera kumatha mwezi umodzi. Mlingo amasankhidwa ndi dokotala payekhapayekha. Chithandizo chimachitika molamulidwa ndi kolesterol wa wodwalayo komanso kuchuluka kwa shuga, popeza pamakhala mwayi woti matendawa azikhala ndi matenda ashuga a 2 atatsiriza maphunzirowo.
Simungatenge anthu omwe ali ndi matenda otere:
- chiwindi ndi matenda a impso,
- myopathy
- hypothyroidism.
Komanso, mankhwala osavomerezeka ali ndi pakati, kuyamwa, ana ochepera zaka 18, ndi lactose tsankho.
Chithandizo sichitha kuphatikizidwa ndi mowa komanso cyclosporin immunosuppressant. Chenjezo liyenera kuperekedwa kwa odwala azaka zopitilira 65 ndi anthu amtundu wa Mongoloid.
Pa nthawi ya chithandizo, zotsatirazi mavuto zimachitika:
chizungulire- mutu
- nseru
- kudzimbidwa
- asthenia
- thupi lawo siligwirizana
- matenda a impso.
chizungulireMtengo wa mankhwala okhala ndi mapiritsi 30 ndi ma ruble 870.
Mitu ya mankhwalawa
Akorta ndi generic wa Rosucard, kapena Russian wofanana. Ili ndi chinthu chomwechi. Amapezeka pamapiritsi a 10 ndi 20 mg. Zizindikiro, contraindication ndi zovuta zake ndizofanana ndi za Rosucard. Mtengo wa mankhwalawa ndi wotsika mtengo - 653 rubles.
Atomax Mankhwalawa amapangidwa limodzi ndi Russia ndi India. Chofunikira chachikulu ndi atorvastatin calcium calcium. Amapezeka piritsi.
Amagwiritsidwa ntchito pa cholesterol yayikulu. Odwala ana, amayi apakati ndi oyamwitsa. Chenjezo liyenera kumwedwa chifukwa chophwanya chiwindi, kuthamanga kwa magazi, zovuta za endocrine, uchidakwa wambiri, khunyu.
Mankhwala amatha kuyambitsa mavuto:
- asthenia
- kusowa tulo
- mutu
- kulira m'makutu
- thukuta
- malungo.
Njira ya mankhwala ndi milungu 2-4. Mtengo wa mankhwalawa ndi ma ruble 323.
Lipitor - mapiritsi omwe amachepetsa cholesterol, kapangidwe ka Germany. Zomwe zimagwira ndi atorvastatin. Mtengo wake ndi ma ruble 630.
Pravastatin ndi chithunzi cha kuphatikizika kwa Russia ndi Slovenia. Chomwe chimagwira ndi pravastatin sodium. Ndi cholesterol yayikulu, mankhwalawo amadzetsa nkhawa zake. Amachepetsa kuchuluka kwa triglycerins, otsika osalimba lipoproteins.
Amagwiritsidwa ntchito popewa kubwereza kwa mtima, matenda a mtima, angina pectoris. Kugwiritsidwa ntchito ngati cholumikizira ku zakudya zama lipid zotsika.
Mankhwalawa adapangidwa chifukwa cha matenda a chiwindi, pakati komanso mkaka wa m'mawere, kumwa mowa mwauchidakwa.
Njira yochizira imachokera masiku 7 mpaka 28. Imachitika ndikuwunika pafupipafupi milingo ya lipid.
Mtengo wa mankhwalawa ndi ma ruble 650 a mapiritsi 10.
Mutha kulowetsa Rosucard ndi mapiritsi opangidwa ku Romania - Simvastol. Mphamvu yogwira ya mankhwala ndi simvastatin. Amatsitsa cholesterol yamagazi. Njira ya chithandizo ndi miyezi 1-1.5.
Amawonetsedwa ngati cholesterol yokwanira komanso matenda a mtima.
Chithandizo cha mankhwala ndi contraindicated mu matenda:
- khunyu
- matenda a chiwindi
- hypotension
- kuvulala kwaposachedwa ndi ntchito.
Zitha kuyambitsa mavuto:
chisangalalo- nseru
- chizungulire
- kuchepa magazi
- Kuchuluka kwa ESR
- utachepa potency.
chisangalaloMapiritsi amayenera kuledzera usiku, kumwa bwino ndi madzi. Simalimbikitsidwa kuphatikiza ndi mankhwalawa:
- mankhwala antifungal
- nicotinic acid
- cytostatics
- anticoagulants.
Tiyeneranso kukumbukira kuti kugwiritsa ntchito madzi a mphesa kumawonjezera mphamvu ya mankhwalawa.
Mtengo wa mankhwalawa ndi ma ruble 211.
Ariescor ndi mnzake waku Russia. Zomwe mapiritsiwo akuphatikizira:
- simvastatin
- ascorbic acid
- citric acid
- lactose.
Mtengo wa analog yaku Russia ndi ma ruble 430.
Zokor - mankhwala ozikidwa pa simvastatin. Amagwiritsidwa ntchito pa cholesterol yayikulu. Dziko lomwe limapanga malonda ake ndi Netherlands. Zizindikiro ndi contraindication ndizofanana. Mtengo wake ndi ma ruble 572.
Musanalowetse mapiritsi omwe amachepetsa cholesterol, muyenera kufunsa dokotala.
Zilankhulo zaku Russia ndi zakunja kwa Rosucard
Analogue ndiotsika mtengo kuchokera ku ma ruble 529.
Atorvastatin ndi mankhwala a hypocholesterolemic, omwe amapanga kwambiri ndi HMG-CoA reductase inhibitor: atorvastatin. Awa ndi makapisozi 10, 15 ndi 20 mg. Amasonyezedwa kwa hypercholesterolemia kuchokera kulikonse, matenda obadwa nawo - dysbetalipoproteinemia, hypertriglyceridemia, mitundu ina ya hyperlipidemia, matenda a mtima. Mlingo sudalira mtundu wake ndipo umachokera ku 10 mpaka 80 mg wa mankhwala patsiku. Odwala chiwindi kulephera, munthu tsankho kwa zigawo zikuluzikulu za mankhwala, pa mimba ndi mkaka wa m`mawere, komanso osakwana zaka 18. Zosagwirizana ndi mankhwala ambiri.
Rosistark (mapiritsi) Kutalika: 40 Pamwamba
Analogue ndiotsika mtengo kuchokera ku ma ruble 371.
Rosistark ndi analogue ya Rosucard, yomwe imapezeka m'mapiritsi a 10, 20 ndi 40 mg. Amalembera matenda omwewo monga mankhwala ena, omwe amagwira ntchito omwe ali rosuvastatin, mu mawonekedwe ake ndi contraindication nawonso samasiyana ndi iwo. Zilibe mphamvu pakuchitika kwama psychomotor, chifukwa chake amatha kugwiritsidwa ntchito ndi oyendetsa magalimoto ndi anthu omwe amawongolera zida zina.
Analogue ndiotsika mtengo kuchokera ku ma ruble 305.
Rosulip imapezeka m'mapiritsi. Zogwira ntchito: rosuvastatin. Mlingo: 5 mg, 10 mg, 20 mg, 40 mg. Pokhala choletsa cha HMG-CoA reductase, rosuvastatin amachepetsa cholesterol yamagazi ndi triglycerides ndipo amalembera atherosclerosis, hypercholesterolemia yoyambitsa chifukwa cha chibadwa komanso zifukwa zokhudzana ndi zaka, hypertriglyceridemia. Kuwona kwachilengedwe kwa bioavail kwadulidwe kwambiri mwa anthu amtundu wa Mongoloid, chifukwa chake, mankhwala osokoneza bongo amadziwika mosamala. Mlingo watsiku ndi tsiku, kutengera matendawa komanso kuuma kwake, kuyambira 10 mpaka 40 mg.
Analogue ndiyotsika mtengo kuchokera ku ma ruble 223.
Roxera imagwirizana kwathunthu molingana ndi mawonekedwe ndi malo ena a Rosucard okhala ndi rosuvastatin, amabwera momwe mapiritsiwo ali ndi mulingo wa 5, 10, 15 kapena 20 mg. Mndandanda wolimba wa contraindication ndi zovuta zomwe zingachitike zitha kuwoneka pamwambapa, komanso mawonekedwe ogwiritsira ntchito. Sichigwiritsidwa ntchito molumikizana ndi cyclosporine ndi mankhwala ena.
Mankhwala
The yogwira pophika mankhwala Rosucard rosuvastatin, ali ndi zinthu zoletsa ntchito reductase, ndi kuchepetsa kapangidwe ka mamolekyulu mevalonate, amene amachititsa kaphatikizidwe ka cholesterol koyamba magawo a maselo a chiwindi.
Mankhwalawa ali ndi kutanthauzira kwachulukidwe ka lipoproteins, kuchepetsa kapangidwe kake ndi maselo a chiwindi, omwe amachepetsa kwambiri kuchuluka kwa maselo olemera a lipoprotein m'magazi ndikuwonjezera kuchuluka kwa maselo osapindulitsa a lipoproteins.
Pharmacokinetics wa mankhwala a Rosucard:
- Kuchuluka kwamphamvu kwa magawo a madzi a m'magazi, mutatha kumwa mapiritsi, kumachitika pambuyo pa maola 5,
- The bioavailability ya mankhwalawa ndi 20,0%,
- Kuwonekera kwa Rosucard m'dongosolo kumadalira kuchuluka kwa mulingo,
- 90.0% ya mankhwala a Rosucard amamangilira mapuloteni a plasma, nthawi zambiri, ndimapulogalamu a albumin,
- Kagayidwe kake ka mankhwala a m'magazi a chiwindi koyambira kuli pafupifupi 10,0%,
- Kwa cytochrome isoenzyme No. P450, yogwira popangira rosuvastatin ndi gawo lapansi,
- Mankhwala amatsitsidwa ndi 90.0% ndi ndowe, ndipo maselo am'mimba ndi omwe amachititsa,
- 10,0 imachotsedwa pogwiritsa ntchito maselo a impso ndi mkodzo,
- Pharmacokinetics ya mankhwala a Rosucard sizitengera gulu la odwala, komanso jenda. Mankhwalawa amagwiranso ntchito chimodzimodzi, mthupi la wachichepere komanso mu thupi lokalamba, pokhapokha munthu wokalamba payenera kukhala ndi mlingo wocheperako wothandizidwa ndi cholesterol index m'magazi.
Achire achire zotsatira za mankhwala a Rosacard gulu la statins akhoza kumva pambuyo kumwa kwa masiku 7. Kuchuluka kwa mapangidwe a chithandizo kumatha kuonekera mutamwa mapiritsi kwa masiku 14.
Chofunikira kwambiri pakumwa mankhwalawa ndikuphunzira zomwe mwatsimikiza ndikutsatira malangizowo, ndiye kuti zotsatira za mankhwalawo zidzakhala zochuluka.
Mtengo wa mankhwala a Rosucard umatengera wopanga mankhwalawo, dziko lomwe mankhwalawo amapangidwira. Kufanizira kwa Russia kwa mankhwalawa ndikotsika mtengo, koma zotsatira za mankhwalawa sizimadalira mtengo wa mankhwalawo.
Analog ya ku Russia ya Rosucard, monga momwe amachepetsa mndandanda mu cholesterol yamagazi, komanso mankhwala akunja.
Mtengo wa mankhwala a Rosucard ku Russian Federation:
- Mtengo wa rosucard 10,0 mg (mapiritsi 30) 550.00 ma ruble,
- Mankhwala Rosucard 10,0 mg (ma 90 ma PC.) 1540.00 ma ruble,
- Mankhwala enieni a Rosucard 20,0 mg. (30 tabu.) 860.00 ma ruble.
Moyo wa alumali ndi kugwiritsa ntchito mapiritsi a Rosucard ndi chaka chimodzi kuyambira tsiku lomwe amamasulidwa. Tsiku lotha litatha, mankhwalawa ndibwino kuti asamwe.
Zizindikiro zogwiritsidwa ntchito
Musanagwiritse ntchito mankhwala othandizira kuchepetsa cholesterol m'magazi, ndikofunikira kugwiritsa ntchito njira zosagwiritsa ntchito mankhwala pakukakamiza kwa lipoproteins m'thupi:
- Zochita zolimbitsa thupi
- Kuthetsa zonse zomwe zimapangitsa kuti mukhale mowa (chizolowezi chomwa mowa mwauchidakwa komanso chikonga),
- Tengani zakudya zotsutsana ndi cholesterol kuti muchepetse lipids zamagazi ndikuwotcha mapaundi owonjezera.
Ngati njira zonse zamafuta osagwiritsa ntchito mankhwala a cholesterol sizinapereke zotsatira, ndiye kuti dokotala akuganiza zoika mankhwala a gulu la statin.
Malinga ndi madotolo ambiri, ma statins amayenera kumwedwa limodzi ndi zakudya zamafuta, zomwe zingathandize kwambiri kutsitsa cholesterol index kwakanthawi kochepa.
Nthawi zambiri, ndikusintha kuchuluka kwa mafuta m'thupi m'magazi, ndimagwiritsa ntchito mankhwala omwe ali ndi rosuvastatin yogwira.
Malinga ndi malangizo ogwiritsira ntchito, omwe amapangidwa ndi omwe amapanga mankhwalawa, mankhwala a Rosucard ndi omwe amaperekedwa kuti apatsidwe matenda oterewa:
- Heterozygous hypercholesterolemia,
- Hypercholesterolemia wosakanikirana,
- Maphunziro oyambira a hypercholesterolemia,
- Hypertriglycerinemia,
- Matenda a magazi a m'magazi.
Kugwiritsa ntchito mankhwala Rosucard mu njira zodzitetezera ku matenda:
- Njira zopewera kugunda kwa mtima
- Ndi makonzedwe a thupi pakupanga angina pectoris,
- Kupewa matenda amisala ischemia,
- Popewa kukula kwa mtima matenda a atherosulinosis,
- Popewa kuthamanga kwa magazi mu kalozera wamagazi,
- Pambuyo pa opaleshoni yamitsempha yamagazi.
Nthawi zambiri, ndikusintha kuchuluka kwa mafuta m'thupi m'magazi, ndimagwiritsa ntchito mankhwala omwe ali ndi rosuvastatin yogwira.
Contraindication
Sizingagwiritsidwe ntchito kutsitsa cholesterol index m'magazi a odwala omwe ali ndi zovuta zotere ndi ma pathologies ofunikira:
- Kukhudzika kwambiri kwa thupi pazinthu zomwe ndi gawo la mankhwala a Rosucard,
- Cirrhosis wa chiwindi
- Chiwindi ndi kulephera kwa impso
- Mukuwonongeka kwambiri kwa impso,
- Ndi index yowonjezera ya transaminase,
- Ndi matenda, myopathy,
- Pa nthawi yoyembekezera mwa azimayi,
- Panthawi yodyetsa mwana mkaka wamawere.
Komanso, Rosucard sinafotokozeredwe kwa azimayi azaka zosabereka omwe sagwiritsa ntchito njira zakulera.
Pali zotsutsana ndi kukhazikitsidwa kwa mankhwala a Rosucard, ndi muyezo umodzi piritsi limodzi la gawo la rosuvastatin pa 40.0 milligram:
- Ndi uchidakwa wambiri, mankhwala osokoneza bongo a Rosucard
- Kuwonongeka kwakukulu kwa magwiridwe antchito a impso,
- Pogwiritsa ntchito chiopsezo cha matenda, myopathy,
- Pathology hypothyroidism, m'mawu otchulidwa,
- Chithandizo cha cholesterol yayikulu ndi mankhwala a gulu la fibrate,
- Sepsis m'mwazi
- Hypotension odwala
- Pambuyo pakuchita opaleshoni m'thupi,
- Kukula kwa khunyu m'thupi ndi matenda a minofu,
- Matenda a khunyu,
- Kuphwanya kagayidwe kachakudya mthupi, kamene kamachitika kwambiri.
Osamamwa mankhwala azimayi panthawi yoyembekezera
Momwe mungatenge rosucard?
Mankhwala Rosucard ayenera kumwedwa pakamwa ndi madzi okwanira. Kutafuna piritsi sikuletsedwa, chifukwa amaphimbidwa ndi nembanemba yomwe imasungunuka m'matumbo.
Asanayambe njira yothandizira achire ndi mankhwala a Rosucard, wodwalayo ayenera kutsatira zakudya za anticholesterol, ndipo zakudya ziyenera kutsagana ndi maphunziro onse a mankhwalawa chifukwa cha gawo la rosuvastatin.
Dokotalayo amasankha payekha mlingo wa wodwala aliyense, kutengera zotsatira za mayeso a labotale, komanso kuvomereza kwa thupi la wodwalayo.
Ndi dokotala yekha, ngati pakufunika kutero, amadziwa momwe angasinthe mapiritsi a Rosucard. Kusintha kwa Mlingo ndi kusintha kwina kwa mankhwalawa ndi mankhwala ena kumachitika osapitirira masabata awiri kuchokera nthawi ya makonzedwe.
Mlingo woyambirira wa mankhwala a Rosucard sayenera kupitirira milimita 10,0 kamodzi pa tsiku.
Pang'onopang'ono, mothandizidwa ndi mankhwalawa, ngati kuli kotheka, mkati mwa masiku 30, adokotala asankha kuwonjezera kuchuluka kwake.
Kuti muwonjezere mlingo wa tsiku lililonse wa mankhwala a Rosucard, zifukwa zotsatirazi ndizofunikira:
- Hypercholesterolemia yayikulu kwambiri, yomwe imafunika mlingo waukulu wa mamiligalamu 40.0,
- Ngati pa mlingo wa mamiligamu 10,0, lipogram imawonetsa kuchepa kwa mafuta m'thupi. Dotolo amawonjezera mlingo wa mamilimita 20.0, kapena yomweyo mlingo waukulu,
- Ndi zovuta zazikulu za mtima Kulephera,
- Ndi gawo lapamwamba la matenda, atherosulinosis.
Odwala ena, asanachulukane, amafunika zinthu zapadera:
- Ngati nthenda yama cell ya chiwindi ikugwirizana ndi kuchuluka kwa Child-Pugh ya 7,0, ndiye kuti kuchuluka kwa Rosucard sikokwanira.
- Pofuna kulephera kwa impso, mutha kuyambitsa maphunziro a mankhwalawa ndi mapiritsi 0,5 patsiku, ndipo pambuyo pake mutha kuwonjezera pang'onopang'ono mamiligalamu 20,0, kapenanso mpaka mulingo waukulu.
- Kulephera kwakukulu kwa impso, ma statin saloledwa,
- The zolimba kukula kwa aimpso ziwalo kulephera. Mlingo wokwanira wa mankhwala a Rosucard samatchulidwa ndi madokotala,
- Ngati pali chiopsezo cha matenda, myopathy amafunikanso kuyamba ndi mapiritsi a 0.5 ndipo mlingo wa mamiligalamu 40.0 ndi woletsedwa.
Mlingo kusintha pa mankhwala
Bongo
Mankhwala osokoneza bongo a Rosucard samakhudza mankhwala a pharmacokinetics. Zosintha kuchokera pamankhwala osokoneza bongo sizimachitika. Palibe njira zapadera zopangidwa kuti zithetsere mankhwala osokoneza bongo a Rosucard.
M'pofunika kuchitira mankhwala a bongo wa statins. Ndikofunikira kuyang'anira nthawi zonse momwe chiwindi chikugwirira ntchito ndipo ngati pakufunika kutero, chitanipo kanthu.
Kugwiritsira ntchito hemodialysis, wokhala ndi mankhwala osokoneza bongo a statin, sikuthandiza mthupi.
Kuchita ndi mankhwala ena
M'mayiko ambiri, kugulitsa mankhwala kumachitika kokha monga adokotala amafotokozera, tili ndi mankhwala ambiri pamafayilo omasuka, omwe amalimbikitsa odwala ambiri kuyesa azaumoyo wawo ndikumwa mankhwala ngati omwe amadzipangira okha.
Izi zili ndi zovuta zovuta kuzungulira kwa thupi, chifukwa odwala samaganizira zovuta zonse zoyipa zamankhwala pakhungu. Komanso si anthu ambiri omwe amadziwa momwe mankhwala amathandizirana akamamwa.
Gome limawonetsa zotsatira za kuyesa mankhwala a Rosucard mukamayanjana ndi mankhwala ena:
| Mtundu wa mankhwala ndi mlingo wake wa tsiku ndi tsiku | tsiku ndi tsiku mlingo wa rosucard | kusintha kwa mankhwala a AUC Rosucard |
|---|---|---|
| mankhwala Atazanavir 300.0 mg ndi mankhwala Ritonavir 100.0 mg kamodzi / tsiku., kwa masiku 8. | 10,0 mg kamodzi. | Kuchulukitsa kwa 3.1. |
| Cyclosporine kuchokera 75.0 mg kawiri pa tsiku. mpaka 200.0 mg kawiri pa tsiku., theka la chaka | 10,0 mg | kukwera pa 7.1 p. |
| mankhwala Lopinavir 400.0 mg / mankhwala Ritonavir 100.0 mg kawiri / tsiku. | 20,0 mg | kuchuluka kwa 2.1 p. |
| Mapiritsi a Simeprivir 150.0 mg 1 nthawi / tsiku. | 10,0 mg | 2.80 p |
| Eltrombopak 75.0 mg kamodzi / tsiku. | 10,0 mg | okwera pa 1.6 p. |
| mankhwala gemfibrozil 600.0 mg kawiri / tsiku. | 80.0 mg | kuchuluka kwa 1.90 p. |
| Tipranavir 500.0 mg ndi Ritonavir 200.0 mg | 10,0 mg | kuchuluka kwa 1.40 p. |
| mankhwala Darunavir 600.0 mg ndi mankhwala Ritonavir 100.0 mg kawiri | 10,0 mg | Pamwambapa 1.50 p. |
| mankhwala Itraconazole 200.0 mg kamodzi | 10,0 mg | kuchuluka kwa 1.4 p. |
| Dronwoodone 400.0 mg kawiri tsiku lililonse | palibe deta | kuchuluka kwa 1.2 p. |
| mankhwala Fozamprenavir 700.0 mg ndi mankhwala Ritonavir 100.0 mg kawiri | 10,0 mg | 1.4 p |
| mankhwala Aleglitazar 0,30 mg | 40.0 mg | osatenga nawo mbali |
| Ezetimibe 10,0 mg kamodzi | 10,0 mg | osatenga nawo mbali |
| Fenofibrate 67.0 mg katatu | 10,0 mg | osatenga nawo mbali |
| Silymarin 140.0 mg katatu | 10,0 mg | palibe kusintha |
| Ketoconazole 200.0 mg kawiri | 80.0 mg | palibe kusintha |
| Rifampicin 450.0 mg kamodzi | 20,0 mg | palibe kusintha |
| mankhwala erythromycin 500.0 mg kanayi | 80.0 mg | 20.0% kuchepa |
| Fluconazole 200.0 mg nthawi imodzi | 80.0 mg | osatenga nawo mbali |
| mapiritsi Baikalin 50.0 mg katatu | 20,0 mg | 47.0% yotsika |
Kugwiritsanso ntchito kwa Rosucard ndi ma antacid, okhala ndi luminium ndi magnesium, kumachepetsa kuchuluka kwa statin nthawi 2. Ngati mukugwiritsa ntchito mankhwalawa limodzi ndi maola awiri mpaka atatu, ndiye kuti zotsalazo zimachepa.
Mukaphatikiza pakumwa mapiritsi a rosucard ndi mankhwala omwe ali ndi proteinase inhibitors, ndiye AUC0-24 imachulukirachulukira.
Kwa anthu omwe ali ndi kachilomboka, kachiromboka ndi kotsutsana ndipo pamakhala zovuta zake.
Zotsatira zoyipa
Ngati mumwa mankhwalawo molondola, ndikutsatira malangizo onse a dokotala pa kumwa Rosucard, komanso zakudya, ndiye kuti kupewetsa kwambiri vutoli.
Koma wopangayo adalemba zomwe zimapangitsa kuti thupi lizimva kumwa mapiritsi:
| machitidwe a thupi ndi ziwalo zake | nthawi zambiri | osati nthawi zambiri | nthawi ndi nthawi | milandu yokhayokha | pafupipafupi sizikudziwika |
|---|---|---|---|---|---|
| kayendedwe ka magazi | matenda a heestatic dongosolo - thrombocytopenia | ||||
| endocrine matenda | hyperglycemia - shuga | ||||
| malo amanjenje | Zowawa m'mutu, | kukumbukira kukumbukira | Zosokoneza tulo, | ||
| · Chizungulire, | Matenda a polyneuropathy. | ||||
| kusokoneza kayendedwe ka kayendedwe. | |||||
| mavuto amisala | Zovuta | ||||
| Kumva mantha | |||||
| Chisoni. | |||||
| kugaya chakudya | Zowawa pamimba, | ||||
| Kutsegula m'mimba | |||||
| kudzimbidwa | |||||
| matenda a kapamba - kapamba. | |||||
| kupuma dongosolo | Kudwala kouma kwambiri | ||||
| Kupuma pang'ono | |||||
| · Zimavuta kupuma. | |||||
| hepatic limba | transaminase index mu hepatic organ cell imatuluka | kutupa m'maselo a chiwindi - hepatitis | |||
| khungu mawonekedwe | Zotupa, | Matenda a Johnson-Stevenson | |||
| Ming'oma yazotupa, | |||||
| Kuyabwa kwambiri. | |||||
| mafupa ndi minofu minofu | matenda a myalgia | matenda a myopathy | matenda arthralgia | Kuphwanya kwa Tendon, | |
| Myopathy zamakhalidwe a necrotic. | |||||
| dera | gynecological ziwalo | ||||
| kwamikodzo dongosolo | matenda a urethral - hematuria | ||||
| zambiri zakuphwanya | asthenia matenda | kutupa kumaso ndi miyendo. |
Pafupipafupi mawonekedwe owonetsa pakubwera kwa thupi zimatengera zinthu zambiri:
- Kuchuluka kwa glucose index m'magazi (pamimba yopanda kanthu 5.6 mmol pa lita ndi pamwambapa),
- BMI yapamwamba kuposa kilogalamu 30 pa mita,
- Mafuta am'munsi kwambiri a triglyceride,
- Matenda oopsa.
Kukonzekera, momwe rosuvastatin amagwira ntchito ngati gawo, amapangidwa kwambiri. Zimapangidwa m'maiko ambiri, kuphatikizapo opanga aku Russia.
Zofanizira zapakhomo za mankhwala a Rosucard ndizotsika mtengo kwambiri kuposa ma analogu achilendo.
Mankhwala opangidwa kuchokera ku Russia otchipa ndi othandizanso kuchepetsa cholesterol index, komanso mankhwala akunja, omwe ali mumtengo wamtengo wapatali.
Ndi madokotala okha omwe angasankhe analogue pamankhwala. Mndandanda wa mankhwala Rosucard, komanso zida zake:
- Mankhwala ndi Torvacard,
- Mankhwala a Mertenil,
- Statin Rosuvastatin,
- Mankhwala Krestor,
- Mankhwala a Roxer
- Generic Atorek,
- Mankhwala Zokor,
- Mankhwala Rosuvakard.
Pomaliza
Mankhwala a Rosucard angagwiritsidwe ntchito pochizira cholesterol yayikulu m'magazi, pokhapokha pothandizidwa ndi zakudya za anticholesterol.
Kulephera kutsatira zakudya kumachedwetsa kuchira ndikukulitsa zotsatira zoyipa za mankhwala m'thupi.
Mankhwala a Rosucard sangathe kugwiritsidwa ntchito ngati mankhwala omwe mungamwe, ndipo ngati mukuletsedwa ndikuletsedwa kusintha payekha kuchuluka kwa mapiritsi, komanso kusintha njira yochizira.
Yuri, wazaka 50, Kaliningrad: ma statin adatsitsa cholesterol yanga kukhala yabwinobwino mu masabata atatu. Koma zitatha izi, chindoko chidawukanso, ndipo ndidayenera kumwa mankhwalawo ndimapiritsi a statin kachiwiri.
Ndi pokhapokha pomwe dokotala atasintha mankhwala anga akale kukhala a Rosucard, ndinazindikira kuti mapiritsiwa sangangobweretsa cholesterol yanga mwabwino, komanso sangawonjezere kwambiri pambuyo popita kuchipatala.
Natalia, wazaka 57, Ekaterinburg: cholesterol inayamba kutuluka nthawi ya kusintha kwa thupi, ndipo zakudya sizingachepetse. Ndakhala ndikumwa mankhwala a rosuvastatin kwa zaka ziwiri. Miyezi itatu yapitayo, adotolo adasinthanitsa mankhwala anga akale ndi mapiritsi a Rosucard.
Ndimamva kuthekera kwake nthawi yomweyo ndinamva bwino ndipo ndinadabwa kuti ndimatha kuchepetsa ma kilogalamu 4 a kunenepa kwambiri.
Nesterenko N.A., cardiologist, Novosibirsk Ndimapereka mankhwala kwa odwala anga pokhapokha njira zonse zochepetsera cholesterol zitayesedwa kale ndipo pali chiwopsezo chachikulu cha kukulitsa matenda a cardio, komanso atherosclerosis.
Ma Statin ali ndi zotsatira zoyipa zambiri mthupi, zomwe zimakhudza moyo wa odwala.
Koma pogwiritsa ntchito mankhwala a Rosucard machitidwe anga, ndidazindikira kuti odwala adasiya kudandaula za zovuta za ma statins. Kuthana ndi malingaliro onse ogwiritsira ntchito kupatsa wodwalayo mphamvu zochepa zoyipa za thupi.
