Ubwino ndi kuipa kwa mapiritsi a Amaril: Amati chiyani za iye pakuwunika komanso momwe angamwe mankhwalawa?

Zotsatira za pharmacological

Glimepiride imapangitsa kuti kapamba azitulutsa insulin kwambiri ndikuiponyera m'magazi. Chifukwa cha izi, shuga amachepetsedwa, makamaka mukatha kudya. Mu chiwindi, ntchito yogwira imaphatikizidwa ndi gawo la cytochrome P450 IIC9. Mavuto amatha kuchitika mukamamwa mankhwala ena omwe amapikisana ndi enzyme yomweyo, monga rifampicin kapena fluconazole. Amachotseredwa ndi 60% ndi chiwindi ndipo 40% ndi impso.

Zizindikiro zogwiritsidwa ntchito

Mtundu wa shuga wachiwiri - kwa odwala omwe amadya ndi kuchita masewera olimbitsa thupi samathandiza mokwanira kuti akhale ndi shuga wabwinobwino. Chithandizo cha boma chimati glimepiride ingagwiritsidwe ntchito limodzi ndi jakisoni wa metformin ndi insulin. Dr. Bernstein akuti mankhwalawa ndi ovulaza ndipo ayenera kutayidwa. Werengani zambiri apa Amaryl ndizovulaza ndi momwe mungasinthe.

Kutenga Amaryl, ngati piritsi lina lililonse la shuga, muyenera kutsatira zakudya.

Contraindication	Mtundu woyamba wa matenda a shuga a mellitus, diabetesic ketoacidosis, chikomokere. Matenda akulu a chiwindi ndi impso. Kusagwirizana kwa yogwira mankhwala glimepiride kapena zina za sulfonylurea. Kuperewera kwa zakudya m'thupi, kuperewera kwa zakudya m'thupi, kusamwa kwambiri pakudya m'mimba, kuthana ndi caloric pafupifupi 1000 kcal patsiku kapena kuchepera. Zaka mpaka 18.
Malangizo apadera	Muyenera kusamala ndi hypoglycemia. Werengani nkhani yakuti: “Mwazi Wotsika Magazi (Hypoglycemia)” mosamala. Onaninso zofunikira za zovuta za chisamaliro chazanguzi. M'milungu yoyamba ya kumwa mankhwalawa, glimepiride ndibwino kuti musagwire ntchito yomwe imafunika kuthamanga kwakuthupi komanso kwamaganizidwe. Kuchiza kumakulitsa chiwopsezo chanu mukamayendetsa.
Mlingo	Mlingo woyenera wa Amaril ndi dokotala. Anthu odwala matenda ashuga sayenera kuchita izi okha. Mankhwala amapezeka mosiyanasiyana - mapiritsi a 1, 2, 3 ndi 4 mg. Tengani kamodzi patsiku musanadye kadzutsa kapena chakudya chachikulu choyamba. Mapiritsi amatha kugawidwa pakati, koma osafukulidwa, ayenera kutsukidwa ndi madzi.
Zotsatira zoyipa	Hypoglycemia (shuga m'magazi ochepa) ndimawonekedwe owopsa komanso owopsa. Mavuto ena ndi osowa. Kusanza uku mseru, kumverera kwadzaza m'mimba, kutsegula m'mimba, kuyabwa pakhungu, zotupa. Kuzindikira khungu mpaka dzuwa kumawonjezereka, kusowa kwa sodium m'thupi kumatha kukula. Chifukwa cha kuchepa msanga kwa magazi, masinthidwe angayambe kukulira kwakanthawi.

Mimba komanso Kuyamwitsa	Glimepiride ndi zotumphukira zina za sulfonylurea sizingatengedwe panthawi yoyembekezera komanso poyamwitsa. Ngati mukumva shuga wambiri pa nthawi yoyembekezera, onani zomwe Pregnant Diabetes and Gestational Diabetes. Khalani monga momwe zalembedwera iwo. Osamamwa mapiritsi ochepetsa shuga popanda chilolezo.
Kuchita ndi mankhwala ena	Amaryl amatha kuyanjana molakwika ndi mapiritsi opanikizika, mankhwala osapweteka a antiidal komanso mankhwala ena ambiri otchuka. Werengani zambiri za malangizo ogwiritsira ntchito, omwe ali phukusi ndi mankhwala. Lankhulani ndi dokotala wanu! Muuzeni za mankhwala onse omwe mumamwa.

Bongo

Hypoglycemia yoopsa, yomwe ikhoza kupha anthu akhoza kuyamba. Zizindikiro zake, njira zamankhwala othandizira kunyumba ndi kuchipatala zafotokozedwa pano. Anthu omwe mwangozi kapena mwadala akumeza mapiritsi a glimepiride kapena zotumphukira zina za sulfonylurea amafunikira chithandizo chamankhwala mwadzidzidzi.

Kutulutsa mawonekedwe, moyo wa alumali, kapangidwe kake

Mtundu wa mapiritsi a Amaryl umasiyana malinga ndi mlingo. Mapiritsi ndi yogwira mankhwala glimepiride 1 mg - pinki. 2 mg - wobiriwira, 3 mg - wachikasu, 4 mg - wabuluu. Omwe amathandizira: lactose monohydrate, sodium carboxymethyl wowuma (mtundu A), povidone 25,000, microcrystalline cellulose, magnesium stearate, komanso utoto. Pewani kufikira ana pa kutentha osapitirira 30 ° C. Moyo wa alumali ndi zaka zitatu.

Pansipa pali mayankho a mafunso omwe amafunsidwa kawirikawiri ndi odwala omwe ali ndi matenda ashuga a 2.

Momwe mungatenge Amaryl: musanadye kapena pambuyo chakudya?

Amaryl amatengedwa chakudya chisanadye, kuti nthawi yakwana iyambike kudya momwe chakudya chadyedwera. Monga lamulo, adokotala amalamula odwala matenda ashuga kuti amwe mankhwalawa musanadye chakudya cham'mawa. Ndipo ngati wodwala nthawi zambiri alibe kadzutsa, imwani piritsi musanadye. Mndandanda womwe uli ndi yogwira glimepiride uyenera kutengedwa chimodzimodzi.

Osayesa kudumpha chakudya mutatha Amaril. Muyenera kudya, apo ayi mankhwalawo amachepetsa shuga m'magazi kwambiri ndipo padzakhala hypoglycemia. Uku ndikovuta kwambiri komwe kumatha kuyambitsa zizindikiro zakusiyanasiyana. Kuchokera ku manjenje ndi palpitations mpaka chikomokere ndi imfa. Kuopsa kwa hypoglycemia ndi chimodzi mwazifukwa zomwe Dr. Bernstein samalimbikitsa kuti atenge glimepiride. Pomwe mungagwiritse ntchito ndi njira yodalirika yoperekera matenda ashuga yachiwiri.

Kodi mankhwalawa amagwirizana ndi mowa?

Malangizo ogwiritsira ntchito mapiritsi a Amaril amafunika anthu odwala matenda ashuga kuti asamamwe mowa panthawi yonse ya mankhwala. Chifukwa kumwa mowa kumawonjezera chiopsezo cha matenda a hypoglycemia ndi chiwindi. Kusagwirizana kwa mankhwala glimepiride ndi mowa ndi vuto lalikulu. Chifukwa ndi mankhwala kwa nthawi yayitali, kudya kwa nthawi yayitali, komanso osati kwa chithandizo chanthawi yochepa.

Nthawi yomweyo, odwala omwe ali ndi matenda a shuga 2 omwe samamwa mapiritsi owopsa ndipo amathandizidwa malinga ndi chiwembuchi saloledwa kumwa mowa momwe angathere. Onani nkhani yakuti “Mowa wa Matenda a shuga” kuti mumve zambiri. Mutha kusunga shuga wabwinobwino ndipo nthawi zina mumalolera kumwa kapu kapena awiri osavulaza thanzi.

Kutenga nthawi yayitali bwanji?

Tsoka ilo, palibe chidziwitso chokwanira chambiri kuti atenga Amaril atayamba kuchitapo kanthu. Shuga wamagazi amatsika kwambiri pambuyo pa maola awiri ndi atatu. Mwambiri, mphamvu ya mankhwalawa imayamba kale kwambiri, pambuyo pa mphindi 30-60. Chifukwa chake musachedwe kudya chakudya kuti hypoglycemia isachitike. Zotsatira zilizonse zotengedwa muyezo wa glimepiride zimatha kuposa tsiku limodzi.

Zomwe zili bwino: Amaryl kapena Diabeteson?

Mankhwalawa onse amaphatikizidwa pamndandanda wazipatala zoyipa za matenda a shuga a 2. Ndi bwino kukana kuzitenga. M'malo mwake, gwiritsani ntchito mankhwala othandizira endocrin-patient.com amalimbikitsa.

Yesetsani kudziwa dokotala yemwe adapereka Amaryl kapena Diabeteson ndi zomwe zili patsamba lino. Mankhwala oyamba, a Diabetes, adachulukitsa kufa kwa odwala omwe adamwa. Chifukwa chake, idachotsedwa mwakachetechete ku malonda. Tsopano mutha kugula kokha mapiritsi a Diabeteson MV. Amachita modekha, komabe ndi zovulaza.

Kodi ndibwino kumwa chiyani: Amaryl kapena Glucophage?

Amaryl ndimankhwala ovulaza. Tsambali endocrin-patient.com ikuyesa kukukakamizani kuti mukane kuzilandira. Glucophage ndi nkhani ina. Awa ndi mankhwala oyambira a Metformin, gawo lofunikira la mtundu 2 wa matenda a shuga. Metformin si mankhwala owopsa, koma othandiza kwambiri. Kuti mupewe matenda abwino a shuga, muyenera kusintha kaye ngati zakudya zamafuta ochepa. Chakudya chopatsa thanzi chimaphatikizidwa ndi kugwiritsa ntchito mankhwalawa Glucophage, ndipo, ngati ndi kotheka, komanso ndi jakisoni wa insulini yochepa.

Kodi ndingatenge Yanumet ndi Amaril nthawi imodzi?

Amaryl ndi mapiritsi ena okhala ndi glimepiride sayenera kumwedwa pazifukwa zomwe zafotokozedwa pamwambapa. Yanumet ndi mankhwala osakanikirana okhala ndi metformin. Panthawi yolemba, ndimtengo wokwera mtengo kwambiri ndipo mulibe mnzake wotsika mtengo. Mwakutero, mutha kutenga. Koma mutha kuyesa kuchoka pa iyo kukhala metformin yangwiro, yopambana kwambiri ndi mankhwala onse oyambitsidwa ndi Glucofage. Ngati mungathe kuchita izi popanda kuwonjezera vuto la matenda ashuga, mupulumutsa ndalama zambiri mwezi uliwonse.

Amaril analogues

Panthawi yokonzekera nkhaniyo kuchokera ku ma analogu omwe adagulitsidwa, Glimepirid-Teva okha omwe amapangidwa ndi Pliva Hrvatska, Croatia adagulitsa m'masitolo ogulitsa mankhwala. Nthawi yomweyo, Amaril ali ndi malo ambiri achi Russia, omwe ndi otsika mtengo kwambiri kuposa mankhwala oyambirirawo.

Dzina la malonda	Wopanga
Glemaz	Wodziwika bwino
Glimepiride	Atoll, Pharmproject, Pharmstandard, Vertex
Diamerid	Akrikhin
Glimepiride Canon	Canonpharma

Wopanga aliyense amatulutsa mitundu yonse ya mlingo wa glimepiride - 1, 2, 3 ndi 4 mg. Onani kupezeka kwa mankhwala ndi mitengo yamafesi.

Mankhwala oyamba a Amaryl kapena analogues otsika mtengo: zomwe mungasankhe

Werengani apa chifukwa chake Amaryl ndi mawonekedwe ake ndizovulaza chifukwa chake muyenera kukana kuzitenga komanso zomwe zili bwino kulowa. Tsambali endocrin-patient.com imaphunzitsira momwe angachepetse shuga m'magazi kuti ikhale yokhazikika popanda kusala, kumwa mankhwala oopsa komanso okwera mtengo, jekeseni waukulu wa insulin.

Amaryl M: mankhwala osakaniza

Amaryl M ndi mankhwala ophatikiza matenda a shuga a 2. Muli zinthu ziwiri zogwira piritsi limodzi - glimepiride ndi metformin. Mukamawerenga pamwambapa, glimepiride ndiyabwino ndipo sibwino kuitenga. Koma metformin siyabwino konse, koma ndiyothandiza kwambiri kwa odwala matenda ashuga. Mankhwalawa amachepetsa shuga m'magazi, amateteza ku zovuta za matenda a shuga, amathandizira kuchepetsa thupi komanso kutalikitsa moyo.

Tsambali endocrin-patient.com imalimbikitsa kuti mutenge metformin yangwiro m'malo mwa Amaril M, mankhwala oyamba kwambiri ndi Glucofage. Alinso ndi anzawo aku Russia, omwe ndi otsika mtengo.

Kodi mapiritsi a Amaryl M ali ndi fanizo lotani?

Amaryl M ndi piritsi lophatikiza lomwe lili ndi zosankha ziwiri: glimepiride ndi metformin. Mankhwala onse, kuphatikizapo glimepiride, ndi oyipa. Amatha kutsitsa shuga m'magazi kwa zaka zingapo, kenako matendawa amasintha kukhala mtundu wovuta kwambiri wa shuga. Mwa odwala matenda ashuga omwe amathandizidwa ndi mapiritsi awa, chiwopsezo cha kufa chifukwa cha kugunda kwa mtima ndi sitiroko sikuchepetsedwa, koma ndikuchulukanso.

M'malo moyang'ana kufanana kwa Amaril M, sinthani kwa metformin yoyera. Zabwino koposa zonse, mankhwala omwe adatumizidwa kunja ndi Glucofage. Zili ndiubwino wabwino, ndipo nthawi yomweyo zimakhala ndi mtengo wotsika mtengo. Komanso gwiritsani ntchito njira yothandizira odwala matenda a shuga a 2. Mudzatha kukhala ndi shuga mokhazikika, monga mwa anthu athanzi, wopanda chakudya "chanjala" komanso kuchita masewera olimbitsa thupi.

Amaryl ndiokwera mtengo kwambiri kuposa mapiritsi apikisano, mwachitsanzo, Diabeteson MV kapena Maninil. Chifukwa chake, ochepa odwala matenda a shuga amavomereza, ndipo pali ndemanga zochepa za izi. Kugwiritsa ntchito glimepiride kuwongolera shuga wamagazi kumayambitsa zotsatira zoyipa zazitali. Zalembedwa pamwambapa. Ndemanga zabwino za mankhwala Amaril zalembedwa ndi anthu odwala matenda ashuga omwe samazitenga zaka 1-2 ndipo alibe nthawi yovutikira.

Madokotala ambiri amadziwa kuti glimepiride sikuchepetsa kufa kwa odwala matenda ashuga, komabe akupitiliza kupereka mankhwalawa kwa odwala awo. Chowonadi ndi chakuti m'miyezi yoyamba kutenga Amaril amachepetsa shuga. Odwala amakhutira. Amachoka pa malo a dokotala kwa nthawi yayitali, akumachepetsa ntchito pa iye. M'malo mongomwa mapiritsi owononga, phunzirani njira zamomwe mungapangire matenda a shuga a 2 ndikugwiritsa ntchito. Njira imeneyi imapereka mwayi weniweni wokhala ndi moyo wokalamba kwambiri osakhala olumala.

6 ndemanga pa Amaril

Moni Abambo anga ali ndi zaka 74, kutalika 178 masentimita, kulemera kwa makilogalamu 72. Ali ndi matenda ashuga a 2 kuyambira 2013. Kumayambiriro kwa matendawa, shuga wamagazi adafika pa 16. Dokotala adadziwitsa Maninil 3.5 mg, piritsi 1 kawiri pa tsiku. Dokotala wina wa endocrinologist adati ndikokwanira kumwa piritsi limodzi patsiku, ndipo adatichitira izi kwa zaka zingapo, mpaka posachedwapa. Mu 2017, shuga idagwa kanayi. Mwezi watha, adotolo adachotsa Maninil ndikumuwonetsa Amaril m'malo mwake kamodzi patsiku. Glycated hemoglobin inali pansi pa 5%, koma pakati pa Ogasiti 2017 inali kale 5.99%. M'masabata awiri apitawa, shuga a abambo m'mawa wopanda kanthu ndi 7.5-8.5, ndipo mutatha kudya pambuyo pake 2 imafika 12. Chonde dziwitsani momwe mungayang'anire malangizowo? Zikomo

Mwezi watha, adotolo adachotsa Maninil ndikumuwonetsa Amaril m'malo mwake kamodzi patsiku.

Radish horseradish siwotsekemera. Mankhwala onse awiriwa ndi oopsa. Iwo kwa nthawiyo akuchepetsa magazi, koma samachepetsa kufa kwa odwala, koma, kuwonjezera.

Abambo anga ali ndi zaka 74, kutalika 178 masentimita, kulemera kwa makilogalamu 72. Ali ndi matenda ashuga a 2 kuyambira 2013.

Ndizodabwitsa kuti abambo anu akadali ndi moyobe ndipo amakhalanso ovomerezeka. Anthu ocheperako komanso ochepa thupi Amaril, Maninil ndi mankhwala enanso owopsa amatengedwa kumanda mwachangu kwambiri kuposa odwala omwe ali onenepa kwambiri. Zaka 2-3 zitha kukhala zokwanira. Abambo anu, momwe ndikumvera, adatenga Maninil motalika.

Chonde ndikulangizeni momwe mungasungire zizindikiro?

Kuzindikira mtundu wa matenda ashuga a 2 sikulondola kwa inu. Wodwalayo ali ndi matenda osokoneza bongo a autoimmune, osati kuchepa kwa minofu kumverera, zomwe zimachitika chifukwa cha kunenepa kwambiri.

Muyenera kusinthira kuzakudya zama carb otsika - http://endocrin-patient.com/dieta-pri-saharnom-diabete/ - komanso kubaya insulin ngati pakufunika, kuyambira nkhani iyi - http://endocrin-patient.com/vidy-insulina /. Palibe mapiritsi a shuga omwe amayenera kumwa ndi odwala ochepa kapena owonda, kuphatikiza metformin (Siofor, Glucofage).

Moni, ndikufuna malangizo anu! Mayi anga (azaka 69, kulemera kwake komwe sindikukudziwa, kwathunthu) ali ndi matenda a shuga 2, akhala akudwala kwa zaka zitatu. Poyamba zonse zinkayenda bwino. Posachedwa, adasinthidwa kukhala mapiritsi a Amaryl. Zimawatenga m'mawa pa 4 mg, kenako glucophage ina madzulo. Munjira imeneyi, mwezi wachiwiri. Koma sizinakhale bwino, koma m'malo mwake, thanzi lake lidayamba kuwipira. Sabata ino pafupifupi tsiku lililonse, kudya shuga 12-13. Amadandaula kuti atamwa mankhwalawa m'mawa, Amaryl amayamba kudwala mutu, ndipo shuga samachepa konse. Masomphenya afooka. Kodi timasintha bwanji njira? Kupita kwa madokotala ndikutali kwambiri. Pepani koma mayi kuti tikawatengere kuchipatala.

Sabata ino pafupifupi tsiku lililonse, kudya shuga 12-13. Zimadandaula kuti mutamwa mankhwalawa Amaril m'mawa, shuga samachepa konse. Masomphenya afooka.

Zonsezi zikusonyeza kuti matendawa anasintha kukhala matenda ashuga achiwiri. Kufunika koyamba kuti mugwiritse jakisoni insulini, apo ayi wamkulu sangathe kuzindikira ndikufa.

Kodi timasintha bwanji njira?

Onani nkhani yokhudza matenda a shuga okalamba - http://endocrin-patient.com/diabetes-pozhilych-ludej/. Monga lamulo, njira zosavuta zimagwiritsidwa ntchito. Yesani kuyambitsa jakisoni wa insulin mwachangu kuti muchepetse matenda a shuga. Sizokayikitsa kuti mungachite bwino kuti amayi anu azikupatsani chithandizo chokwanira. Chifukwa anthu okalamba nthawi zambiri amakana kusintha.

Moni Ndili ndi zaka 56, ndakhala ndikudwala matenda ashuga a 2 kwa zaka 4. Ndikumwa Amaryl M pa mlingo wa 2 mg + 500 mg. Masana, shuga sangakhale wamkulu kuposa 8, koma m'mawa umafika 11-14 mmol / l. Ndimayesetsa kutsatira zakudya. M'miyezi yaposachedwa, adatha kutaya 7 kg. Ndazindikira kuti ngati mulibe chakudya chamadzulo, chimodzimodzi, kuchuluka kwa glucose m'magawo m'mawa kukwera kwambiri kuposa masana. Alangizeni momwe mungathetse vutoli ndi shuga m'mawa?

Alangizeni momwe mungathetse vutoli ndi shuga m'mawa?

Choyamba, ndikukulangizani kuti muphunzire mosamala zolemba patsamba lino, kenako kufunsa mafunso mu ndemanga.

Zambiri

Monga tafotokozera mu malangizowo, mapiritsi a Amaril, ndemanga zake zomwe zimakhala zabwino kwambiri, ali m'gulu la mayina a hypoglycemic. Chofunikira chachikulu pazomwe zimapangidwira ndi glimepiride. Ndi m'badwo wachitatu, kutengera urea sulfonyl. Mothandizidwa ndi pawiri mu thupi, mapangidwe a insulin amayamba chifukwa chothandiza kukonza kwa ma cell a ma kanyumba. Chinanso chowonjezera chomwe chimapangitsa kuti mankhwalawo azigwira bwino ntchito ndikuwonjezereka kwa chidwi chachilengedwe cha insulin. Malinga ndi akatswiri, kutenga Amaril moyang'aniridwa ndi dokotala woyenera ndikutsatira malangizowo kumakuthandizani kuti muzitha kuyendetsa bwino magazi a wodwala.

Monga tawonera, “Amaril” (malangizo omwe amagwiritsidwa ntchito nthawi zonse) amapezeka akugulitsidwa piritsi. Makapisozi amadzaza matuza okhala ndi mapiritsi 15. Bokosi limodzi lokhathamiritsa limaphatikizapo matuza awiri. Pali zosankha zinayi: mapiritsi a pinki, obiriwira (mtundu woyamba uli ndi piritsi yogwira mu 1 mg, yachiwiri imakhala ndi kuchuluka kokwanira), mamilimita achikasu achikasu ndi amtambo abuluu. Mapeto ake, ndende ndizokwanira - 4 mg. Kuphatikiza pa gawo lalikulu, zida zina zowonjezera zinagwiritsidwa ntchito. Mndandanda wathunthu wazolumikizidwa walembedwa pamalangizo.

Zimagwira bwanji?

Kupanga kwa mphamvu ya mankhwala pthupi la munthu akuwonetsedwa mu malangizo a Amarila (1 mg, 2 mg, 3 mg, 4 mg). Pulogalamu yayikulu, yotchedwa glimepiride, ndi yogwirizana ndi mankhwala a m'badwo wachitatu ndipo imayambitsa ntchito yowonjezera yamaselo a pancreatic cell. Mothandizidwa ndi pawiri, maselo omwe amakhala ndi chimbudzi amagwira ntchito mwachangu kwambiri. Nthawi yomweyo, glimepiride imakhudza ulusi wa minofu, zomanga zamafuta, zomwe zimakulitsa chiwopsezo cha mahomoni.

Zotsatira zoyambirira zomwe zatchulidwa zimatchedwa pancreatic. Monga tawonetsera malangizo a Amarila (2 mg ndi mankhwala ena), zotsatira zake zimakhala zochepa pakumwa mankhwalawa, zomwe zikutanthauza kuti palibe chiopsezo cha hypoglycemia ndi mlingo wokwanira wa mankhwalawa. Glimepiride amachepetsa kukana kwa insulini, kuchuluka kwa atherogenic lipoprotein tizigawo ta magazi kumachepa. Magazi amayamba kuchepa, kupsinjika kwa oxidative sikumatchulidwa.

Malangizo aukadaulo

Amarila Instruction (4 mg ndi mitundu ina ya mankhwalawa) idzafotokoza tanthauzo lenileni la bioavailability pazomwe zimagwira. Ngati mukugwiritsa ntchito mankhwalawa amavomerezedwa ndi dokotala ndi wopanga, palibe zotsatira zowonjezereka zomwe zimawonedwa. Glimepiride m'magazi oyenda mozungulira mumayang'aniridwa pambuyo pa maola 2,5 kuchokera nthawi yomwe mankhwalawa amamwa. Mu seramu yamagazi, magawo a piritsi ndi okhazikika ndipo samatsimikiziridwa ndi kuchuluka kwa chakudya. Kutha kwa theka-moyo kuli mpaka maola asanu ndi atatu.

Malangizo a mapiritsi a Amaril amatchula kuthekera kwa kulowa kwa wothandizirayo kudzera mu chotchinga chachikulu. Kafukufuku wasonyeza kuti chinthu chogwira ntchito chimadutsa mkaka wa m'mawere. Kugwiritsa ntchito mankhwalawa panthawi ya gestation ndikofunikira. Mimba ikapezeka, chithandizo chikuyenera kusiyidwa.

Kodi ndizotheka kapena ayi?

Monga kutsatira malangizowo, mankhwalawa "Amaril" ayenera kugwiritsidwa ntchito ngati mtundu wachiwiri wa matenda ashuga wakhazikika. Mutha kugwiritsa ntchito chida ngati njira yokhayo yachipatala pakuwongolera mkhalidwe wa wodwalayo. Amaloledwa kuphatikiza dzinalo ndi insulin, metformin.

Saloledwa kugwiritsa ntchito chida ngati matenda a matenda oyamba a mtundu woyamba apezeka, chikomokere kapena mtundu womwe umagwirizana ndi matenda a shuga. Amaryl si yoyenera kuthandizira odwala omwe ali ndi ketoacidosis, komanso kwa iwo omwe ali ndi vuto lalikulu la chiwindi, aimpso. Sichivomerezedwa kugwiritsa ntchito dzinali panthawi ya bere, poyamwitsa. Osagwiritsa ntchito mankhwalawa mowonjezera chidwi chilichonse chomwe chimagwiritsidwa ntchito popanga zinthu. Izi sizikugwira ntchito kokha kwa anthu omwe chiwopsezo chawo chadziwika pakadali pano, komanso ngati zingatchulidwepo m'mbiri yamankhwala.

Kulondola sikungapweteke

Monga momwe malangizo a gwiritsani ntchito, Amaril (2 mg ndi mitundu ina ya mankhwala) angagwiritsidwe ntchito mwanjira zina zapadera za wodwalayo pokhapokha poyang'aniridwa mwamphamvu ndi zamankhwala zofunikira za thupi. Izi zimaphatikizapo kupsa, opaleshoni yokonzekera, kutsekeka kwamatumbo, mitundu yosiyanasiyana yamatumbo adsorption. Izi zimaphatikizanso ndi zovulala zazikulu zingapo. Ngati pakufunika kusamutsa wodwala kupita ku insulin mankhwala, izi zimachitika pokhapokha ngati zingatheke, kuti mugwiritse ntchito zizindikiro, zowunika momwe wodwalayo akumvera mapiritsi.

Momwe mungagwiritsire ntchito?

Kwa Amaril, malangizo ogwiritsira ntchito (3 mg ndi njira zina zomasulira) akuwonetsa mitundu iwiri yogwiritsira ntchito - monga njira yokhayo yolungisa mkhalidwe wa wodwalayo komanso ngati chinthu chovuta kuchira. Mwanjira zilizonse zomwe mungasankhe, nthawi ya maphunziridwe, kuchuluka kwa mankhwalawa omwe agwiritsidwa ntchito, mawonekedwe omwe amasulidwa amasankhidwa ndi adokotala potengera chidziwitso chomwe chimapezeka kuchokera ku mayeso a labotale, maphunziro othandizira a momwe wodwalayo alili. Saloledwa kugwiritsa ntchito Amaril mwakufuna kwake, kukonza pulogalamu yomwe dokotala wakonza.

Monga mankhwala okhawo, Amaril amalembedwa koyamba m'mitundu yaying'ono - osaposa milligram patsiku. Popita nthawi, kuwonjezereka kwa ndende kumaloledwa, koma osapitilira milligram milungu iwiri. Malangizo ogwiritsira ntchito mapiritsi a Amaril ali ndi chidziwitso cha kutsika kwa mlingo wa tsiku ndi tsiku osapitirira 6 mg. Chibowo chilichonse chimayenera kutengedwa pakamwa, popanda kuphwanya umphumphu wa nthawiyo, kumwa madzi ambiri. Amaryl imagwiritsidwa ntchito kamodzi patsiku, mwina asanadye chakudya cham'mawa, kapena nthawi yoyamba kudya masana. Pofuna kupewa hypoglycemia, ndikofunikira kudya chakudya Amarila atamwidwa.

Kuphatikizika, mafomu omasulidwa

Zomwe zimagwira ku Amaril ndi chimodzi chokha - glimepiride . Zinthu zotsalazo ndizothandiza.
Mapiritsi a Amaril amapezeka mu mitundu inayi yosiyanasiyana (1, 2, 3 ndi 4 mg ya glimepiride).

Kutengera mtundu wa glimepiride, mapiritsiwo amakhala osiyanasiyana:

Amaryl 1 mg - mapiritsi a pinki (30, 60, 90 kapena 120 ma PC. Paketi iliyonse),
Amaryl 2 mg - mapiritsi obiriwira (kuchuluka komweko mu phukusi),
Amaryl 3 mg - mapiritsi achikasu owala (kuchuluka komweko mu phukusi),
Amaryl 4 mg - mapiritsi a buluu (kuchuluka chomwecho mu phukusi).

Mapiritsi onsewa ali ndi mawonekedwe okumbika pansi, mbali zonse - cholembedwa "NMK" ndi "ff".

Palinso mankhwala ophatikiza Amaril M, yomwe, kuwonjezera pa glimepiride, imaphatikizanso wothandizira wina wa hypoglycemic - metformin.

Mapiritsi a Amaryl M amapezeka mu mitundu iwiri:

1 mg glimepiride, 250 mg metformin,
2 mg glimepiride, 500 mg metformin.

Mapiritsi onsewo ndi oyera pamtundu, biconvex, oval mawonekedwe, wokutidwa ndi filimu wokutira, ndipo ali ndi "HD25" wolemba mbali imodzi.

Zochita pa thupi

Glimepiride imakhudzanso kapamba, kuyang'anira kupanga insulin, ndi kulowa kwake m'magazi. Ndipo insulin imayamba kale kuchepetsa magazi. Kuphatikiza apo, glimepiride imalimbikitsa kutuluka kwa calcium kuchokera m'magazi kupita m'maselo a minofu. Imalepheretsanso kupangika kwa zolembera za atherosselotic pamakoma amitsempha yamagazi.

Metformin imachepetsa kuchuluka kwa shuga m'magazi munjira ina: imasintha magazi mu chiwindi, ndikuwonjezera kutembenuka kwa shuga (glucose) kukhala glycogen wodwala wodwala matenda ashuga. Metformin imathandizanso kutulutsa shuga m'maselo a minofu.

Zizindikiro zogwiritsidwa ntchito

Mankhwala a Amaryl ndi Amaryl M ali ndi chisonyezo chimodzi chokha choti agwiritse ntchito: mtundu wa 2 matenda a shuga (osagwirizana ndi insulini - i.e., osagwiritsidwanso ntchito pomaliza mankhwala a insulin).

Pochita, zidapezeka kuti zotsatira za Amaril (glimepiride) zimatheka chifukwa cha kuphatikiza kwake ndi metformin. Kenako kukonzekera kophatikizidwa Amaril M. kunapangidwa kuti kukhale kothandiza kwa odwala ndi madokotala.

Zotsatira zoyipa

Zotsatira zoyipa kwambiri pakugwiritsa ntchito Amaril ndi Amaril M ndi hypoglycemia (kuchepa kwa shuga m'magazi m'munsi mwabwinobwino).

Zotsatira zina zoyipa sizachilendo, koma zimatha kusokoneza zochitika zamagulu ndi machitidwe ambiri.
Zotheka kuzimva mu dongosolo lamanjenje:

mutu, chizungulire,
kugona, kapena, kusokoneza tulo,
kukwiya, kulephera kudziletsa,
kukhumudwa
kufooketsa ndende, kuchepa kwa mayankho,
mavuto a kulankhula
zamkhutu
manja ndi miyendo akunjenjemera
kukokana
kulephera kudziwa.

Zomwe zimachitika mu mtima:

kukomoka mtima,
kupweteka kwa mtima
kutentha kwa mtima
kuchuluka kwa kuthamanga kwa magazi.

Zomwe zimachitika mu chimbudzi:

njala
kusanza, kusanza,
kupweteka kapena kumva kuwawa m'mimba,
kutsekula m'mimba (m'mimba)
kusayenda kwa bile
hepatitis (chosowa kwambiri).

Zotheka kuzimva mu hematopoietic system:

kuchepa magazi (kuchepa kwa ndende ya hemoglobin),
kuchepa kwa chiwerengero cha maselo amagazi osiyanasiyana (maselo ofiira a magazi, maselo oyera am'magazi, mapulateleti, ndi zina zambiri).

Zomwe zimayambitsa matupi awo ndi zotupa pakhungu limodzi ndi kuyabwa.

Kumayambiriro kwa chithandizo, kuwonongeka kwakanthawi kochepa kumatha kuzindikirika.

Mlingo ndi Ulamuliro

Mlingo wa mankhwala a Amaryl ndi Amaryl M amathandizidwa ndi dokotala aliyense payekha kwa wodwala aliyense, kutengera kuchuluka kwa shuga ya wodwalayo.

Chithandizo cha Amaril nthawi zambiri chimayamba ndi 1 mg. Wodwalayo amatenga kumwa kamodzi patsiku - m'mawa, asanadye chakudya cham'mawa, kapena nthawi yake. Mapiritsi ayenera kutsukidwa ndi madzi okwanira (osachepera 0,5 makapu), mapiritsi sayenera kutafunidwa.

Ngati ndi kotheka, adotolo amawonjezera pang'onopang'ono tsiku lililonse la Amaril, pogwiritsa ntchito chiwembu: 1 mg - 2 mg - 3 mg - 4 mg - 6 mg - 8 mg. Amaryl 4 mg nthawi zambiri amagwiritsidwa ntchito ngati mlingo waukulu wa tsiku lililonse. Kukhazikitsidwa kwa Amaril mu gawo la 6 ndi 8 mg ndiye, kupatula.

Pakatikati ya kuchuluka kwa mlingo uyenera kukhala masabata awiri.
Kuchiza kumayendetsedwa ndi mayeso oyenera kuti azindikire kuchuluka kwa shuga kwa wodwala.

Malingana ndi mfundo yomweyo, mlingo wa mankhwalawa Amaryl M. umatsimikiza. Mlingo wa tsiku ndi tsiku umagwiritsidwa ntchito mu 1 mgulu, kapena umagawidwa pawiri. Omwe amagwiritsidwa ntchito kwambiri ndi Amaryl M 2 mg + 500 mg.

Ngati wodwala wayiwala kuphonya mankhwalawo (Amarila kapena Amarila M), masiku awa amaphonya popanda mankhwala. Palibe chifukwa chowonjezera kuchuluka kwa mankhwalawa ndi makonzedwe ena ake.

Ndikofunika kwambiri kuti wodwala akangomwa mapiritsi musaiwale kudya. Kupanda kutero, shuga m'magazi amatsika pang'ono.

Makamaka mankhwalawa amasankhidwa mosamala ndi okalamba odwala (motsogoleredwa ndi impso).

Malangizo owonjezera

Dokotala, pofotokozera wodwala Amaryl kapena Amaryl M, ayenera kuchenjeza za kuthekera kwa zotsatirapo zoyipa, ndipo koposa zonse - za kupezeka kwa hypoglycemia ngati wodwalayo amamwa mankhwalawo, koma amaiwala kudya. Potere, wodwalayo akulimbikitsidwa kuti nthawi zonse azinyamula maswiti kapena shuga pazidutswa kuti athe kukweza msanga shuga.

Kuphatikiza pa kupenda kwa magazi ndi mkodzo mwatsatanetsatane, mankhwalawa Amaril ndi Amaril M amathanso kuwunika kuchuluka kwa magazi ndi ntchito ya chiwindi.

M'mikhalidwe yovuta, yotsatana ndi kutulutsidwa kwa adrenaline m'magazi, mphamvu ya Amaril ndi Amaril M imachepa. Zinthu ngati izi zimatha kukhala ngozi, mikangano m’banja kapena kuntchito, matenda omwe akukwera kwambiri. Zikatero, kusunthira kwakanthawi kwa wodwala kupita ku insulin kumachitika.

Kuyanjana kwa mankhwala

Mankhwala ena omwe amagwiritsidwa ntchito nthawi yomweyo ndi Amaril (Amaril M) amalimbikitsa zotsatira zake, pomwe ena amafooketsa. Mndandanda wazomwezi komanso zina zamankhwala ndizabwino kwambiri. Chifukwa chake, wodwalayo, akakumana ndi dokotala wosadziwika, ayenera kufotokozera za matenda ake (matenda ashuga), ndikuti akutenga Amaril. Dokotala adzalembera mankhwala omwe sagwirizana ndi Amaril chithandizo, kapena asinthe mlingo wa mankhwalawo ngati pakufunika kutero.

Kugwiritsidwa ntchito kwa Amaril ndi Amaril M pamodzi ndi mowa kumapereka malingaliro osayembekezeka: mphamvu ya Amaril imatha kuchepa kapena kuwonjezeka.

Ndemanga zingapo za odwala omwe amathandizidwa ndi Amaril ndi Amaril M, amafotokoza chifukwa chakuti mankhwalawa amathandiza kwambiri pamene mlingo wa mankhwalawo umasankhidwa ndi dokotala moyenera.

Ndemanga kuti zotsatira zoyipa kwambiri za Amaril ndi Amaril M ndi hypoglycemia (kutsika kwakukulu kwa kuchuluka kwa shuga m'magazi) kumatsimikiziridwa ndi ndemanga. Odwala amafotokoza zizindikiro za hypoglycemia monga kufooka lakuthwa, chizungulire, njala, manja akunjenjemera ndi thupi lonse. Ngati simuchita chilichonse, mutha kuzindikira. Chifukwa chake, anthu ambiri omwe ali ndi matenda ashuga omwe amalandila chithandizo ndi Amaril (Amaril M) nthawi zambiri amakhala ndi shuga pazidutswa kapena maswiti. Pambuyo podya shuga, wodwalayo amawonjezera msanga wamagazi m'magazi, ndipo amakhala bwino.

Nthawi zina, oyendetsa magalimoto amadandaula za kuchepa kwa machitidwe poyendetsa. Izi zikugwirizana ndi zovuta zomwe zatchulidwa mu malangizo ndi manjenje.

Ndemanga zambiri amavomereza kuti mitundu yosiyanasiyana ya mapiritsi a Amaril imathandizira kuti asasokoneze mlingo.

Odwala ena, makamaka okalamba, kuvomereza kuthandizira kwa Amaril (Amaril M), amawona kuti mtengo wake ukadali wokwera kwambiri.

Mtengo wa mapiritsi a Amaryl (mapiritsi 30 pa paketi iliyonse), kutengera mlingo, ndi ma ruble 203 - 840.

Mtengo wa mapiritsi a Amaryl M (miyala 30 pamapaketi iliyonse) ndi:

Amaril M 2mg + 500mg: 411 - 580 rubles.
Amaril M mu kipimo cha 1 mg + 250 mg pafupifupi sanafotokozeredwe ndi madokotala, ndipo sichachilendo m'mafakitore.

Phatikizani kuti mupindule

Malangizo ogwiritsira ntchito "Amaril" ali ndi zisonyezo za malamulo ogwiritsira ntchito kuphatikiza ndi mayina ena azachipatala. Ndizotheka kugwiritsa ntchito mankhwalawa ngati wodwala akuchitidwa ndi metformin. Ndikusunga Mlingo wa wothandizirayu, Amaril amachita ngati njira yowonjezerapo yamankhwala. Poyamba, dzinalo limayikidwa mu 1 mg tsiku, pang'onopang'ono kuchuluka kwa nthawi, mpaka zotsatira zokhazikika za hypoglycemic zithe.

Kwa tsiku limodzi, wopanga mu malangizo ogwiritsira ntchito "Amaril" amalimbikitsa kusankha zosaposa 6 mg pazomwe zimagwira. Glimepiride ndi insulin mankhwala zimachepetsa kufunikira kwa dzina lachiwiri ndi 40% (nthawi zina zochepa).

Zotsatira zosasangalatsa: zomwe muyenera kukonzekera?

Monga tikuwonera kuchokera pakuwunika, malangizo, Amaril ikhoza kuyambitsa mavuto. Palibe chodabwitsa mu izi - ali ndi mitundu ya mankhwala omwe amapangidwa kuti achepetse shuga m'magazi. Amaryl imatha kuyambitsa hypoglycemia. Monga lamulo, wodwalayo nthawi yomweyo amamva kufooka, kugona, kupweteka mutu, kuda nseru, nseru ndizotheka.Amadziwika kuti mukamagwiritsa ntchito "Amaril" pamakhala mwayi wokweza chopondapo, ntchito zam'mimba, matumbo. Ndi chithandizo chazitali, pamakhala chiopsezo cha masinthidwe oyipa m'thupi. Pali chiopsezo cha kuchepa kwa magazi m'thupi, thrombocytopenia. Kuyankha kwakutheka, chidwi chochulukirapo.

Ndemanga, malangizo "Amarila" amatchula zovuta zina za kugona. Kafukufuku akuwonetsa kuti mwayi wa zotulukazi ndizochulukirapo, komabe, ndizoposa zero. Komanso, ndizotheka kwambiri, malo osokoneza, osakhazikika ndizotheka. Odwala ena amamva chizungulire, amayamba kunjenjemera, kulephera kwamalingaliro kumawonedwa, mavuto ndi mgwirizano wogwirizana ndiwotheka. Nthawi zina, kuphwanya kwamphamvu kugunda kwa mtima, kukhumudwa, chisokonezo chinajambulidwa. Mukamasintha kuchuluka kwa shuga m'magazi, pamakhala mwayi wamatenda owoneka, koma kusintha koteroko kumasinthiratu.

Malamulo ogwiritsira ntchito: ndikofunikira kutsatira

Malangizo a Amarila amapereka chitsogozo pazochitika zina zapadera. Makamaka, ngati gawo lalikulu kwambiri la mankhwala othandizira alowa mthupi, pamakhala chiopsezo cha hypoglycemia. Kuti muchepetse zotsatira zoyipa, kuyambitsidwa kwa glucose kumafunika. Mwambowu uyenera kuchitika mosamalitsa ndi kuyang'aniridwa ndi dokotala, koma posachedwa.

Gwiritsani ntchito molingana ndi malangizo "Amaryl" angagwiritsidwe ntchito kuphatikiza ndi mayina ena a mankhwalawa, koma ndikofunikira kuti muthe kuzindikira zomwe zimathandizirana. Mphamvu ya hypoglycemic yothandizira pakamwa imayambitsidwa ngati wodwala agwiritsa ntchito insulin, amatenga ma anabolics, ma steroid, metformin, androgen mankhwala, allopurinol, coumarin, komanso zotumphukira za mankhwala. Ndi kulondola kwakukulu, Amaril amalembedwa kwa anthu omwe amakakamizidwa kuchita mankhwala a chloramphenicol, antidepressants ochokera ku gulu lomwe limalepheretsa kugwidwa kwa MAO, miconazole. Zotsatira za kutenga Amaril zitha kukulira mosakonzekera pamene quinolones, tetracycline, ndi pentoxifylline zimalowetsedwa. Kuletsa kwapadera kumakhazikitsidwa ndikugwiritsa ntchito ma salicillates, mayina ena kuchokera m'gulu la sulfonamides.

Zina zomwe muyenera kuyang'ana?

Malangizo a Amarila akuwonetsa kuti kuphatikiza kwina ndi mayina ena a mankhwalawa pali chiwopsezo cha kuchepa kwa zotsatira za hypoglycemic. Izi ndizotheka pogwiritsa ntchito barbiturates ndi mitundu ina ya okodzetsa, komanso kuletsa njira zotupa za corticosteroids. Amaril amagwira ntchito yofooka ngati wodwala amatenga mankhwala otupa, mahomoni ogonana achikazi ndi mahomoni a chithokomiro. Kuchepa kwa mphamvu ya hypoglycemic kumawonedwa limodzi ndi nicotinic acid, sympathomimetics, ndi rifampicin.

Langizo la Amarila likuwonetsa kuchepa kwa mphamvu ya mankhwala ngati wodwala adya mosasamala, mosakwanira, ndikuledzera. Mphamvu ya kudya imakhala yotsika ngati zakudya zimadzaza ndi chakudya. Nthawi zina, ndikofunikira kusintha mulingo woyenera wa mankhwalawo, ndikuyang'ana kuchuluka kwa thupi la wodwalayo. Dokotala amasankha njira yabwino kwambiri pogwiritsa ntchito njira zapadera zowerengera.

Kutalika komanso mwamphamvu

Kutenga nthawi yayitali Amaril kumatheka pokhapokha ngati nthawi zonse aziona kuyamwa kwa shuga m'thupi. Kuphatikiza apo, ndikofunikira kuyang'ana magwiridwe antchito a chiwindi ndi impso, kuwunika mawonekedwe a magazi amodzi.

Ngati mankhwala osokoneza bongo amawonedwa, pamakhala chiwopsezo cha kuchepa kwa ndende. Izi ndizofunikira kwambiri ngati wodwala tsiku lililonse amayendetsa kapena akukumana ndi zochitika zina zomwe zimafuna chisamaliro chachikulu komanso kuthana kwambiri.

Maonekedwe, mapasiwedi

Amaril imawonetsedwa m'mashelu apamu pamitengo ya 250 mpaka 1000 rubles. Kusintha kwakung'ono ndikotheka, zambiri zimatengera ndondomeko yamitengo yazogulitsa. Zosankha zotsika mtengo kwambiri ndi mulingo wa milligram, ndipo zotsika mtengo kwambiri ndi 4 mg. Mapaketi okhala ndi makapisozi okhala ndi 2 mg ya yogwira popanga mtengo pafupifupi ma ruble 500, ndi 3 mg - pafupifupi 770 ma ruble.

Ngati sizotheka kulandira zomwe zasankhidwa, Amarila analogues akhoza kupulumutsa. Malangizo ogwiritsira ntchito posankha wogwiritsa ntchito othandizira akuyenera kuwunikidwa bwino kwambiri, ndipo kuyikanso kuyenera kuchitika pokhapokha mogwirizana ndi adotolo, apo ayi pamakhala mwayi woti ayankhe molakwika kuchokera ku thupi, ndipo kuchitira kwake bwino sikokwanira. Mwa fanizo, mayina "Altar", "Diabresid", "Glemaz" ndiofala. Nthawi zina madokotala amalimbikitsa kuti mukhale ndi imodzi mwazithandizo izi:

Zambiri pazofanizira: Glimepiride

Pansi pa dzina ili, mankhwala omwe amachokera pazomwe zimagwiritsidwa ntchito amagulitsidwa. Pali mitundu isanu: 1, 2, 3, 4, 6 mg. Kuphatikiza pazinthu zazikulu, zida zothandizira zinagwiritsidwa ntchito. Ndikofunikira kwambiri kuti mudziwe mndandanda wonse ngati wodwala akuvutika ndi lactose, cellulose, kapena mankhwala ena onse omwe amagwiritsidwa ntchito pamakampani opanga mankhwala. Mapiritsi onse a Glimepiride ali ndi utoto womwe umapereka kusiyana kwa mitundu. Mlingo wocheperako umapakidwa utoto wofiira wachitsulo, chifukwa ma milligrams awiri chitsulo oxide kapena alarnum varnish amagwiritsidwa ntchito. 3 mg ali okongoletsedwa ndi iron iron oxide, 4 mg ndi indigo carmine.

Makapisozi amadzaza matuza a aluminium ndi polyvinyl chloride. Bokosi limodzi lokhazikika lili ndi chithuza chimodzi. Mulingo uliwonse payokha piritsi ya cylindrical yokhala ndi notch, alama.

Kodi ntchito?

"Glimepiride" idapangidwa kuti ichiritse odwala omwe ali ndi matenda osokoneza bongo amtundu wodziimira payekha, ndiye mtundu wachiwiri. Mothandizidwa ndi pulo yogwira, ma cell a ma kondomu amawongolera ndipo insulin imatulutsidwa ndi beta-form. Mankhwalawa, monga ena a m'gulu lomwelo, amatha kutseka njira ya potaziyamu, kudalira ATP, m'matumbo a kapamba. Kuchita koteroko kumakwiyitsa beta-cell depolarization, kumalimbikitsa kutseguka kwa njira za calcium, zomwe insulin imamasulidwa. Chowoneka mosiyana ndi ichi ndi kulowetsedwa mwachangu ndi ma protein a membrane, ngakhale chomangira chimakwaniritsidwa kudzera munjira zina. Izi zimasiyanitsa Glimepiride ku mankhwala ena kuchokera ku gulu la sulfonylurea.

Kulandila kwa "Glimepiride" sikumayambitsa kuletsa kwa mtima njira za ATP, zomwe zimadalira potaziyamu. Mothandizidwa ndi phula, chiwopsezo cha minofu, minofu ya adipose ku insulin imayendetsedwa. Ma cell a Hepatic amagwiritsa ntchito timadzi tokhala ndi ntchito zochepa. Glimepiride amatha kuyambitsa ntchito za zida zina za enzyme, zomwe zimapangitsa kuti glyco-, hypogeneis iwonjezeke. Mlingo wodziwikiratu umatsimikiziridwa ndi kuchuluka kwa mankhwalawa. Pachimake zolimbitsa thupi limodzi ndi ntchito mankhwala limodzi ndi kuchepa kwa insulin (monga kulibe thandizo linalake). Mankhwalawa ali ndi katundu wa antioxidant, amachepetsa kukhuthala kwa magazi, ali ndi mphamvu ya antiatherogenic.

Mawonekedwe akugwiritsidwa ntchito

"Glimepiride", monga zikuwonetsedwera ndi maphunziro azaachipatala, amalengezedwa kuchokera kumimba yopita m'mimba mpaka muyeso womwewo ndi chakudya, ndipo popanda iwo. The bioavailability pafupifupi mtheradi, akuti pafupifupi zana limodzi. Kuti tikwaniritse ndende yayikulu kwambiri m'thupi, pafupifupi mphindi 150 ndizofunikira. Kuwonekera kwa mankhwalawa kumakhala kwakanthawi, ndipo kumangiriza kwa mapuloteni a plasma kumakulitsidwa. Ziwerengero zopanda pake zimapereka chisonyezo cha 95%. "Glimepiride" imatha kulowa mkati mwa placenta, yomwe imawonedwa mkaka wa m'mawere, yomwe idakhala maziko oletsedwa kwa mankhwalawa panthawi yapakati. Chiwerengero chochepa chogwira ntchito chimatha kudutsa chotchinga-magazi.

Hafu ya moyo ndi maola osachepera asanu, koma osaposa asanu ndi atatu ndi magwiridwe antchito amthupi ndi minofu. Nthawi yayitali imafunika ngati wodwala wapatsidwa mlingo waukulu. Zimadziwika kuti glimepiride imasinthidwa m'maselo a chiwindi, ndipo enzyme ya CYP2C9 imatenga nawo mbali pazomwe zimachitika. Opitirira theka la metabolites amachoka m'thupi kudzera mu kwamikodzo, pafupifupi gawo lachitatu - lokhala ndi ndowe. Palibe zopweteketsa mtima. Pharmacokinetics ndizogwirizana kwambiri ndi jenda, zaka za wodwalayo.

Zizindikiro ndi contraindication

Glimepiride imagwiritsidwa ntchito ngati mtundu wachiwiri wa matenda a shuga ukhazikitsidwa, ndiye kuti, popanda insulin. Amayamba kugwiritsa ntchito mankhwalawa pokhapokha ngati sizotheka kusintha momwe wodwalayo alili ndi njira zofatsa - kuchepa thupi, zolimbitsa thupi, kusintha kwa zakudya.

"Glimepiride" sangatengedwe ngati apezeka ndi ketoacidosis, matenda ashuga achititsa khansa, kupweteka kwa chiwindi ndi impso kwambiri. Glimepiride silinapangidwe kuti athandizire odwala omwe ali ndi mtundu woyamba wa matenda a shuga, komanso azimayi onyamula mwana wosabadwayo kapena woyamwitsa. Chogwiritsidwachi sichikugwiritsidwa ntchito pozindikira kuyankha kwamthupi kwa chilichonse chomwe chimagwiritsidwa ntchito popanga Glimepiride.

Amaryl: malangizo ogwiritsira ntchito

Kodi mankhwalawa amagwira ntchito bwanji?

Atatha kumwa mankhwalawa, kapamba amayambitsa, zomwe zimapangitsa kuti apange insulin ndikuwadyetsa m'magazi. Izi zimathandizira kuchepetsa magazi pambuyo chakudya.
The oxidation wa glimepiride mu chiwindi kumachitika ndi nawo gawo la enzyme kuchokera pagulu P450. Chifukwa chake, ngati munthu amwa mankhwala ena omwe amafunikira cytochrome iyi, mavuto ena angabuke pakugwira ntchito kwa thupi. Mankhwalawa amaphatikizapo fluconazole ndi rifampicin.
Glimepiride imachotsedwanso ndi chiwindi mu 60% komanso impso zake 40%.

Mukatenga nthawi yanji

Mankhwalawa amaperekedwa kwa anthu omwe ali ndi matenda a shuga a mtundu wachiwiri ndipo sangathe kuyendetsa chitukuko cha matendawa kudzera pakudya komanso zolimbitsa thupi.
Amaloledwa kuphatikiza Amaril ndi jakisoni wa metformin ndi insulin.

Kodi osavomera

Zotsatira zoyenera kumwa mankhwalawa ndi:

Mtundu woyamba wa shuga.
Coma ndi ketoacidosis.
Kusalolera payekha pazinthu zomwe zimapanga mankhwala.
Zolakwika zazikulu mu zakudya.
Matenda am'mimba, omwe amaphatikizidwa ndi malabsorption a chakudya.
Kuchepetsa zopatsa mphamvu tsiku ndi tsiku zosakwana 1000 kcal.
Age ali ndi zaka 18.

Zomwe muyenera kulabadira mwapadera

Mankhwalawa, pamakhala chiopsezo cha hypoglycemia, makamaka chifukwa cha kuchuluka kwa mankhwala tsiku lililonse. Ngati munthu ali ndi zisonyezo zoyambirira zaumoyo uno, ndiye muyenera kuyimba ambulansi posachedwa.
M'masabata oyambilira a 1-2 pambuyo poyambira kulandira mankhwala ndi Amaril, ndikofunikira kuchepetsa ntchito, yomwe imafunikira zolimbitsa thupi. Ndikofunikira kwambiri kusiyira kasamalidwe ka mayendedwe aliwonse.

Simungasankhe nokha mtundu wa mankhwalawa, uwu ndiudokotala.
Mutha kupeza mapiritsi okhala ndi mulingo wa 1, 2, 3 ndi 4 mg. Imwani mankhwalawa kamodzi pa maola 24 aliwonse, musanadye chakudya cham'mawa.
Piritsi liyenera kumezedwa lonse. Ngati ndi kotheka, ikhoza kugawidwa m'magulu awiriawiri, koma mankhwalawo sangathe kutafuna. Amaryl amatsukidwa ndi madzi.

Choyipa choopsa kwambiri komanso chofala kwambiri ndi hypoglycemia. Zina zomwe zimachitika mthupi zimaphatikizaponso: kuyabwa khungu, zotupa pakhungu, mseru komanso kusanza. Mwina kukula kwa khungu hypersensitivity kupita ku radiation ya ultraviolet. Pogwiritsa ntchito nthawi yayitali, pali kusowa kwa sodium m'thupi.
Nthawi zina odwala amadandaula chifukwa cha kuwonongeka kwakanthawi kowonekera, zomwe zimachitika chifukwa cha kuchepa msanga kwamagazi m'magazi.

Kuchepetsa ndi pakati

Panthawi yobala mwana komanso nthawi yoyamwitsa, Amaril sanalembedwe.

Kumwa mankhwalawo ndi mankhwala ena

Sikulimbikitsidwa kuphatikiza kutenga Amaril ndi mankhwala ena, monga: mankhwala ochepetsa magazi, NSAIDs, etc. Chifukwa chake, musanayambe chithandizo, muyenera kulandira upangiri wa udokotala. Ngati wodwala akutenga mankhwala aliwonse, ndiye kuti ayenera kudziwitsa dokotala yemwe akhudzidwa ndi matenda a shuga.

Ngati bongo umachitika

Kumwa mlingo waukulu wa mankhwala kumayenderana ndi chiopsezo cha hypoglycemia. Izi zimafunika kuchipatala mwadzidzidzi.

Kutulutsa mawonekedwe, mawonekedwe osungira, mawonekedwe

Amaryl akupezeka piritsi.
Mtundu wa mapiritsiwo udzasiyana, kutengera mtundu wa mankhwalawo:

Mapiritsi a buluu ali ndi muyezo wa 4 mg.
Mapiritsi achikasu ali ndi mlingo wa 3 mg.
Mapiritsi obiriwira ali ndi mlingo wa 2 mg.
Mapiritsi a pinki ali ndi mlingo wa 1 mg.

Kuphatikiza pa chophatikizira chachikulu (glimepiride), mankhwalawa ali ndi zigawo zothandizira: povidone, lactose monohydrate, sodium carboxymethyl stack, cellulose, magnesium stearate, utoto.
Ndikofunikira kusunga mankhwalawo pamtunda wa mpweya osapitirira 30 ° C.
Alumali moyo wa mapiritsi ndi zaka zitatu.

Amaril kutengera chakudya

Amaryl amatengedwa chakudya chisanadye, kotero kuti glimepiride imayamba kugwira ntchito pofika chakudya. Madokotala amalimbikitsa kumwa Amaril musanadye chakudya cham'mawa. Ngati munthu akana kudya m'mawa, pazifukwa zingapo kapena zina, ayenera kumwa mapiritsi a Amaril asanadye.

Malangizo omwewo okhudza makonzedwewo amagwiranso ntchito kwa mankhwala ena omwe ali ndi fanizo la Amaril.

Kudya utatha kumwa mankhwalawa ndikofunikira, apo ayi munthu akhoza kuyamba kukhala ndi hypoglycemia, momwe shuga ya magazi imatsikira kwambiri.

Kutengera ndi kuopsa kwa maphunziridwe a hypoglycemia, amatha kuwonetsedwa pamlingo wowonjezereka wa mtima komanso mpaka kutsika.

Kodi ndingatenge Amaryl ndikumwa mowa?

Pa chithandizo ndi Amaril, ndikofunikira kusiya kumwa mowa. Ngati izi sizitsatiridwa, ndiye kuti munthuyo akhoza kukhala ndi hypoglycemia. Chiwindi chimatha kukhudzidwanso. Kwa anthu ambiri, kukana mowa kwathunthu ndi vuto lalikulu, chifukwa chithandizo cha matenda ashuga chiyenera kupitiliza moyo wonse.

Chifukwa chake, ngati wodwalayo sangathe kuletsa mowa, ayenera kusinthana ndi mankhwala ena kuti muchepetse shuga.

Zimatenga nthawi yayitali bwanji kuti Amaril ayambe?

Mwazi wa magazi umachepetsedwa monga momwe mungathere patatha maola pafupifupi atatu mutamwa mankhwalawa. Asayansi akukhulupirira kuti mankhwalawa amayamba kugwira ntchito kwa theka la ola - ola limodzi asanafike magazi ambiri m'magazi. Chifukwa chake, simungathe kuchedwetsa chakudya mpaka tsiku lotsatira, apo ayi munthu adzakumana ndi hypoglycemia.

Mankhwalawa amagwira ntchito maola 24 mukatha kutsata.

Amaryl kapena Diabeteson - kusankha?

Mankhwala a Diabeteson sanagulitsidwe; pakadali pano, mankhwala omwe amatchedwa Diabeteson MV ndi omwe amapezeka m'masitolo ogulitsa. Awa ndi mankhwala amibadwo yatsopano omwe amakhala osalala kuposa omwe adalipo kale.

Ngati munthu akuganiza za kusankha mankhwala ati - Diabeteson kapena Amaril, ndiye kuti ayenera kufunsa dokotala kuti athetse vutoli.

Kodi ndizotheka kuphatikiza kulandilidwa kwa Amaril ndi Yanumet?

Yanumet ndi mankhwala osakanikirana ozikidwa pa metformin. Ili ndi mtengo wokwera kwambiri ndipo ilibe anzako otsika mtengo. Mutha kuyesa kuyamba kulandira mankhwala omwe ali ndi mankhwala amodzi okha - metformin. Chida choyambirira chomwe chimakhazikitsidwa ndi Glucophage. Nthawi zina madokotala amalimbikitsa kuti odwala matenda ashuga aphatikizire kumwa Amaril ndi Yanumet mu njira yovuta, koma simungathe kudziphatika nokha

Zofananira za Amaril

Analogue ya Amaril yopanga ndalama zakunja ndi mankhwala a Glimepirid-Teva. Zimapangidwa ndi kampani yaku Croatia Pliva Hrvatska.

Zofananira zaku Russia za Amaril ndi:

Glemaz, wochokera ku kampani Valeant.

Glimepiride kuchokera kumakampani Atoll, Pharmproekt, Pharmstandart ndi Verteks.

Diameride kuchokera ku kampani ya Akrikhin.

Glimepiride Canon kuchokera ku kampani ya Canonpharm.

Onse opanga amapanga mankhwala awo mu gawo la 1, 2, 3, 4 mg. Mtengo wa mankhwala enaake uyenera kufotokozedwa m'mafakisi.

Amaryl M ndi mankhwala osakanikirana omwe, kuphatikiza glimepiride, metformin ilipo. Izi zimakuthandizani kuti muchepetse misempha ya magazi kwambiri komanso muteteze munthu ku zovuta za shuga, zomwe zingakhale zovuta kwambiri.

Komabe, chithandizo chimayambika bwino ndi mankhwala ozikidwa pa metformin yokha. Ngati kufunika komwe sikukwaniritsidwa, muyenera kupeza upangiri wa udokotala.

Terms a Tchuthi cha Pharmacy

Amamasulidwa pa mankhwala.

Kodi Amaryl ndi ndalama zingati? Mtengo wapakati pama pharmacies umatengera mtundu wa kumasulidwa:

Mapiritsi a Amaryl 1 mg, 30 ma PC. - kuchokera 262 rub.
Mapiritsi a Amaryl 2 mg, 30 ma PC. - kuchokera pa 498 rub.
Mapiritsi a Amaryl 3 mg, 30 ma PC. - kuchokera 770 rub.
Mapiritsi a Amaryl 4 mg, 30 ma PC. - kuchokera 1026 rub.

Kutulutsa mawonekedwe ndi kapangidwe kake

Amaryl ikupezeka piritsi la mapiritsi mu mitundu ingapo: 1, 2, 3 ndi 4 mg. Katundu wake ali chifukwa cha chinthu chomwe amagwira - glimepiride, zotumphuka za sulfonylurea. Monga zinthu zothandizira, lactose monohydrate, povidone, magnesium stearate, microcrystalline cellulose ndi utoto wa E172 kapena E132 amagwiritsidwa ntchito.

Mosasamala za kuchuluka kwa mapiritsi, mapiritsi onse amatha kudzipatula ndipo adalemba. Monga gawo losiyanitsa - mtundu wa piritsi lokha: 1 mg pink, 2 mg wobiriwira, 3 mg wotuwa wachikasu ndi 4 mg wabuluu.

Zotsatira za pharmacological

Glimepiride - zomwe zimagwiritsidwa ntchito ndi mankhwalawa - zimakhala ndi mphamvu pa kapamba, zimathandiza kuwongolera kupanga kwa insulin ndi kulowa kwake m'magazi. Chifukwa chake, insulin imachepetsa shuga m'magazi.

Chifukwa cha zotsatira za glimepiride, calcium yochokera m'magazi imalowa m'maselo a minyewa ndikuthandizira kupewa mapangidwe a atherosselotic plaret pamakoma amitsempha yamagazi.

Metformin imathandizanso kuchepetsa shuga m'magazi, koma mwanjira ina: imasintha magazi mozungulira hepatic ndikusintha shuga m'magazi kukhala glycogen, chinthu chomwe ndichopulumutsa kwa odwala matenda a shuga. Kuphatikiza apo, metmorphine imalimbikitsa kuyamwa kwabwino kwa glucose ndi maselo amisempha.

Zinapezeka kuti glimepiride ndiyothandiza kwambiri kuphatikiza ndi metformin. Pazifukwa izi, Amaryl M adapangidwa - mankhwala omwe ndi oyenera kwa onse odwala ndi madokotala.

Contraindication

Malinga ndi malangizo, Amaryl imaphatikizidwa pazotsatirazi:

Matenda obadwa nawo (kusowa kwa lactase, galactose tsankho, shuga-galactose malabsorption),
Hypersensitivity kwa yogwira kapena yothandizira zigawo za mankhwala,
Mtundu woyamba wa shuga
Kukanika kwa chiwindi,
Matenda a shuga komanso chikomokere, matenda ashuga a ketoacidosis,
Mimba ndi kuyamwitsa,
Kusokonekera kwambiri kwa ntchito ya chiwindi (kuphatikiza odwala pa hemodialysis),
Zaka za ana.

Pogwiritsa ntchito Amaril, kusamala kuyenera kugwiritsidwa ntchito ngati:

Kuphwanya mayamwidwe chakudya ndi mankhwala kuchokera m'mimba thirakiti (m'matumbo paresis, m'mimba kutsekeka),
Kukhalapo kwa chiopsezo cha hypoglycemia,
Matenda apakati pamankhwala kapena moyo wa wodwala ukasintha (kusintha kwa zakudya kapena nthawi yakudya, kuchepa kapena kuwonjezeka kwa zochitika zolimbitsa thupi),
Glucose-6-phosphate dehydrogenase akusowa.

Mimba komanso kuyamwa

Amaryl amadziwikiridwa ndi pakati. Ngati mayi wapezeka kuti ali ndi pakati kapena pokhapokha ngati ali ndi pakati, mkazi ayenera kuthandizidwa ndi insulin.

Zakhazikitsidwa kuti glimepiride imatulutsidwa mkaka wa m'mawere. Pa nthawi ya mkaka wa m'mawere, muyenera kusamutsira mkaziyo ku insulin kapena kusiya kuyamwitsa.

Zotsatira zoyipa

Kugwiritsa ntchito Amaril kumatha kupangitsa zotsatirazi:

Matumbo oyenda m'mimba: kawirikawiri - kupweteka kwam'mimba, kugwidwa ndi mseru, kutsegula m'mimba, kusanza, kumverera kwodzaza ndi kulemera kwa epigastrium, nthawi zina - kuwonjezeka kwa ntchito ya cholestasis ndi / kapena michere ya chiwindi, chiwindi, jaundice, chiwopsezo cha chiwopsezo cha moyo.
Gulu lamasomphenya: kumayambiriro kwa zamankhwala, kusokonezeka kwapang'onopang'ono kwakanthawi kumatheka, ndikusintha mwa kusintha kwa glucose m'magazi.
Dongosolo la hematopoietic: nthawi zina - granulocytopenia, leukopenia, pancytopenia, hemolytic anemia, agranulocytosis ndi erythrocytopenia, kawirikawiri thrombocytopenia. Pogwiritsa ntchito Amaril pambuyo pa malonda, milandu ya thrombocytopenia ndi thrombocytopenic purpura yanenedwapo.
Mawonekedwe a mziwopsezo: kawirikawiri - pseudo-thupi lawo siligwirizana (urticaria, zotupa pakhungu ndi kuyabwa). Izi zimachitika nthawi zambiri zimakhala zofatsa, koma zimatha kuthana ndi kuthamanga kwa magazi, kupuma movutikira, mantha anaphylactic, ziwengo zosagwirizana ndi msambo (munthawi zina).
Metabolism: monga momwe zimapezekera ndi zinthu zina za sulfonylurea, hypoglycemia yomwe imatenga nthawi yayitali. Zizindikiro za matendawa ndi mseru, kupweteka mutu, kusanza, kugona ndi kutopa, kusokonezeka kwa tulo, kugona, kusokonezeka kwa tulo, kupsinjika, kudziletsa, kusokonezeka maganizo komanso kuthamanga kwa zochitika, kusokonezeka kwa mawonekedwe, kukhumudwa , delirium, chisokonezo, kusokonezeka kwa malankhulidwe, aphasia, kugwedezeka, chizungulire, kukokana kwa ziwalo, kupuma kosakhazikika, kulephera kugona mpaka kugona. Kuphatikiza apo, pakhoza kukhala zizindikiro za kutsutsana ndi adrenergic poyankha hypoglycemia (nkhawa, mawonekedwe a thukuta lovuta kwambiri, angina pectoris, tachycardia, kusokonezeka kwa mtima, palpitations ndi arterial hypertension. Chithunzi cha chipatala cha hypoglycemia choopsa chimafanana ndi sitiroko.
Zina: nthawi zina - photosensitivity, hyponatremia.

Zizindikiro zosokoneza bongo: hypoglycemia yoopsa, yotalikitsa moyo (yopereka mankhwala kwa nthawi yayitali ndi glimepiride muyezo waukulu komanso mankhwala osokoneza bongo owopsa.

Bongo

Ndi bongo wa Amaril, nseru, kupweteka kwam'mimba, komanso kusanza kumatha kuchitika. Hypoglycemia imatha kuchitika, komwe kumachitika kunjenjemera, nkhawa, kuwonongeka kwa mawonekedwe, kugona, kusokonekera bwino, kukokana, kukomoka.

Pankhani ya mankhwala osokoneza bongo, kutsuka kwa chapamimba kumasonyezedwa, mutatha kugwiritsa ntchito enterosorbents. Kuwongolera kwa glucose kuyenera kuyambitsidwa mwachangu. Kuperekanso chithandizo kumakhala chizindikiro. Mwa mankhwala osokoneza bongo osokoneza bongo, kuthandizidwa kuchipatala kumalo osamalira odwala kumafunika.

Malangizo apadera

Kuphatikiza pa kupenda kwa magazi ndi mkodzo mwatsatanetsatane, mankhwalawa Amaril ndi Amaril M amathanso kuwunika kuchuluka kwa magazi ndi ntchito ya chiwindi.

Kugwiritsa ntchito komweko kwa amaryl ndi insulin, mankhwala ena ochepetsa shuga, maantibayotiki ena (ma tetracyclines, sulfanilamides, clarithromycin), mlingo waukulu wa pentoxifylline, fluoxetine, fluconazole, anabolic steroids, ACE inhibitors (Captoprilprin, drilopril, erin, priloprilprin. . Kuphatikizidwa kwa amaryl ndi barbiturates, mankhwala opatsirana, ma diuretics, mlingo waukulu wa nicotinic acid, ndi rifampicin adzakhala ndi zotsutsana.

Beta-blockers (carvedilol, atenolol, bisoprolol, metoprolol, etc.), reserpine, clonidine, zotumphukira za coumarin ndi mowa zimatha kuwonjezera ndikuchepetsa mphamvu ya hypoglycemic ya amaryl.

Pogwiritsa ntchito Amaryl pa matenda a shuga a 2, ndemanga zinalandira kuchokera kwa odwala ambiri. Izi zikutsimikizira kuti, ngati mulingo woyenera, mankhwalawa amalimbana ndi hyperglycemia. Kuphatikiza pakuchita bwino, ogula ambiri adatcha mitundu yosiyanasiyana ya mapiritsiyo ngati abwino a mankhwalawa - izi zimathandiza kuti asasokoneze mankhwalawo ndi muyeso wina wa glimepiride.

Ndemanga zomwe zalandiridwa pa Amaril sizinangotithandizanso, komanso zovuta zomwe zawonetsedwa m'malamulo opita ku Amaril. Nthawi zambiri, odwala omwe amamwa mankhwalawa amawonetsa zizindikiro za hypoglycemia:

Zofooka.
Kutentha.
Kugwedezeka thupi lonse.
Chizungulire
Kuchulukitsa chilakolako.

Nthawi zambiri, chifukwa cha hypoglycemia mu shuga mellitus, pamakhala ngozi yotaya chikumbumtima.

Chifukwa chake, iwo omwe amatenga Amaril amayenera kumanyamula nthawi zonse zinthu zokhala ndi shuga (mwachitsanzo, maswiti), kuti ngati zingafunike azitha kuwonjezera msanga komanso azikhala wathanzi.

Komabe, malinga ndi madotolo, kusintha kwa shuga sikuti kukuwonetsa kuti mankhwalawo alibe mphamvu. Zizindikiro zotere zikawoneka, ndikokwanira kusintha mlingo.

Vuto lodziwika kwa madalaivala omwe amakakamizidwa kuti achite ma hypoglycemic othandizira limakhala likuipiraipira poyendetsa galimoto. Zotsatira zoyipa zofananazo zikuwonetsedwa mu malangizo omwe ali mndandanda wazotsatira zoyipa. Kutsika kwake kumachitika pofotokoza chifukwa cha glimepiride yamatsenga.

Mwa odwala omwe ali ndi matenda ashuga okalamba, mu ndemanga ya Amaril, ambiri adanenanso za vuto limodzi: ngakhale kuti Amaril amatsitsa shuga, mankhwala a shuga ndiokwera mtengo kwambiri, chifukwa mankhwalawa atha kulipira ndalama zambiri kuposa ena kupanga.

Zofanana ndi zomanga za Amaril zimaphatikizapo mankhwala: Glemaz, Glumedeks, Meglimid, Diamerid.

Musanagwiritse ntchito fanizo, funsani dokotala.

Amaril mankhwala a m'badwo watsopano

Malangizo a Amaril omwe amagwiritsidwa ntchito amapereka chiyeso ngati mankhwala am'badwo watsopano wamankhwala kuthana ndi matenda a shuga a 2. Chimodzi mwabwino kwambiri lero chinali Glibenclamide-HB-419 kuchokera ku gulu la sulfonylurea. Oposa theka la odwala matenda ashuga omwe ali ndi mtundu wachiwiri adakumana nawo.

Amaril ndi mtundu wosinthika wa Glibenclamide, wopangidwa kuti ukwaniritse zofunikira zatsopano zowongolera "matenda okoma."

Pharmacological mawonekedwe a mankhwala

Amaryl ndi mankhwala a hypoglycemic omwe amathandiza kuwongolera dzuwa la plasma. Yogwira pophika mankhwala ndi glimepiride. Monga omwe adatsogolera, Glibenclamide, Amaril ndiwonso wochokera ku gulu la sulfonylurea, lomwe limalimbikitsa kapangidwe ka insulin kuchokera ku maselo a b pancreatic a Langerhans.

Kuti akwaniritse zomwe akufuna, amatseka njira ya potaziyamu ya ATP ndi chidwi chochulukirapo.

Sulfonylurea ikalumikizana ndi ma receptor omwe ali pamalimba a b-cell, zochitika za gawo la K-AT zimasintha.

Kutsekeka kwa njira za calcium ndi kuwonjezeka kwa kuchuluka kwa ATP / ADP mu cytoplasm kumapangitsa kuti membrane awonongeke. Izi zimathandiza kumasula njira za calcium ndikuwonjezera kuchuluka kwa calcium ya cytosolic.

Zotsatira za kukopa kwachidziwikire kwa ma granules achinsinsi, komwe ndi njira yotulutsira mankhwala ophatikizira pakati pa maselo, ndikutulutsa kwa insulin m'magazi.

Glimepiride ndi woimira m'badwo wachitatu wa sulfonylureas. Zimapangitsa kuti amasulidwe mahomoni a pancreatic mwachangu, amathandizira chidwi cha insulini cha mapuloteni komanso maselo a lipid.

Tizilomboti timatulutsa michere timagulugasi timagwiritsa ntchito mapuloteni ochokera ku ma cell a cell. Ndi mtundu wodziimira payekha wa shuga, kusintha kwa shuga m'matipi kumachepetsedwa. Glimepiride imalimbikitsa kukwera kwa kuchuluka kwa mapuloteni oyendetsa ndikuwonjezera ntchito yawo. Mphamvu yamphamvu kwambiri ya kapamba imathandizira kuchepetsa kukanira kwa insulin (insensitivity) kwa mahomoni.

Amaryl imalepheretsa kuphatikizika kwa glucogen ndi chiwindi chifukwa cha kuchuluka kwa kuchuluka kwa fructose-2,6-bisphosphate ndi antiaggregant (chopinga cha kupangidwa kwa thrombus), antiatherogenic (kuchepa kwa zizindikiro za cholesterol "choyipa") komanso antioxidant (kusinthika, kuthana ndi kukalamba). Njira za oxidation zimachepetsedwa chifukwa chowonjezeka pazomwe zimakhala za end-native b-tocopherol komanso ntchito ya antioxidant enzymes.

Ngakhale milingo yaying'ono ya Amaril imathandizira kwambiri glucometer.

Pharmacokinetics wa mankhwala

Popanga Amaril, gawo lalikulu lomwe limagwira ndi glimepiride kuchokera ku gulu la sulfonylurea. Povidone, lactose monohydrate, magnesium stearate, microcrystalline cellulose ndi utoto wa E172, E132 amagwiritsidwa ntchito ngati ojambula.

Amaryl imayendetsa michere ya chiwindi 100%, kotero ngakhale kugwiritsidwa ntchito kwa nthawi yayitali kwa mankhwalawa sikuwopseza kudzikundikira kwake pazinthu komanso minyewa. Zotsatira zakonzedwe, zotumphukira ziwiri za glipemiride zimapangidwa: hydroxymetabolite ndi carboxymethabolite. Metabolite yoyamba imapatsidwa mankhwala omwe amapereka chokhazikika cha hypoglycemic.

M'magazi, zomwe zimakhala pazomwe zimagwira ntchito zimawonedwa pakatha maola awiri ndi theka. Kuwona zamtundu wathunthu wa bioavailability, mankhwalawa saletsa odwala matenda ashuga posankha zakudya zomwe "agwiritse" mankhwalawo. Mafuta adzakhala mulimonse 100%.

Likukhalira kuti mankhwala pang'onopang'ono, mlingo wa kumasulidwa kwa zimakhala ndi madzi kuchokera ku mankhwala (chilolezo) ndi 48 ml / min. Kutha kwa theka-moyo kumachokera ku maola 5 mpaka 8.

Kuwongolera kwakukulu kwa glycemic indices kumawonedwa ngakhale ndi zovuta ndi chiwindi, makamaka, mukulira (wazaka zoposa 65) komanso ndi vuto la chiwindi, kugwiritsidwa ntchito kwa chinthucho ndi kwachibadwa.

Momwe mungagwiritsire ntchito Amaryl

Mankhwala amapangidwa mwanjira ya mapiritsi ozungulira omwe ali ndi mzere wogawa, womwe umakulolani kuti mutha kugawa mlingo mosavuta pakati. Mtundu wa mapiritsiwo umatengera mlingo: 1 mg wa glimepiride - chipolopolo, 2 mg - khungu, 3 mg - chikasu.

Kapangidwe kameneka sikanasankhidwe mwamwayi: ngati mapiritsi amatha kusiyanitsidwa ndi mtundu, izi zimachepetsa chiopsezo cha bongo mwangozi, makamaka mwa okalamba.

Mapiritsi amayikidwa m'matumba a 15 ma PC. Bokosi lililonse limatha kukhala ndi mbale ziwiri mpaka 6.

Njira ya mankhwala ndi mankhwala ndi yayitali, ali ndi malingaliro ambiri. Mwachitsanzo, simungalumphe chakudya chotsatira mukamamwa mankhwalawo.

Zomwe mungagwiritse ntchito pa Amaril:

Piritsi (kapena gawo lake) limamezedwa lonse, kutsukidwa ndi madzi osachepera 150 ml. Mukangomwa mankhwala, muyenera kudya.
Endocrinologist amasankha dongosolo la mankhwalawa malinga ndi zotsatira za kusanthula kwa zinthu zachilengedwe.
Yambani maphunzirowa ndi ma Mlingo wocheperako wa Amaril. Ngati gawo la 1 mg patapita nthawi yochepa silikuwonetsa zotsatira zomwe zakonzedwa, mulingowo umachuluka.
Mlingo umasinthidwa pang'onopang'ono, mkati mwa masabata 1-2, kotero kuti thupi likhale ndi nthawi yosinthira kuzatsopano. Tsiku lililonse, mutha kuwonjezera kuchuluka kwa osaposa 1 mg. Mulingo waukulu wa mankhwalawa ndi 6 mg / tsiku. Mulingo wokhazikitsidwa ndi adokotala.
Ndikofunikira kukonza zomwe zimachitika ndikusintha kwa kulemera kwa odwala matenda ashuga kapena kuchuluka kwa mitsempha ya minofu, komanso kuwoneka ngati chiwopsezo cha hypoglycemia (ndi njala, kuperewera kwa zakudya m'thupi, kuledzera, mavuto a impso ndi chiwindi.
Nthawi yogwiritsira ntchito komanso mlingo wake zimatengera mtundu wamoyo ndi mawonekedwe a kagayidwe. Nthawi zambiri, kamodzi pamakonzedwe a Amaril amakhazikitsidwa patsiku limodzi ndi chakudya. Ngati chakudya cham'mawa chadzaza, mutha kumwa mapiritsi m'mawa, ngati chophiphiritsa - ndibwino kuphatikiza phwando ndi nkhomaliro.
Mankhwala osokoneza bongo amawopseza ndi hypoglycemia, pomwe shuga m'mitsempha amatsika mpaka 3.5 mol / L kapena kutsikira. Vutoli limatha kupitilira kwa nthawi yayitali: kuchokera maola 12 mpaka masiku atatu.

Mapiritsi a Amaryl (phukusi la zidutswa 30) amagulitsidwa pamtengo wa:

260 rub - 1 mg,
500 rub - 2 mg aliyense
770 rub. - 3 mg aliyense
1020 rub. - 4 mg aliyense.

Ubwino ndi kuipa kwa mapiritsi a Amaril: Amati chiyani za iye pakuwunika komanso momwe angamwe mankhwalawa?

Anthu ambiri ali ndi matenda ashuga. Komanso, chaka chilichonse chiwerengero cha anthu omwe akudwala matendawa chikukula.

Ndikosatheka kuchiritsa matendawa, komabe, ndizotheka kuzilamulira ndikukhalabe bwino.

Kuti muchite izi, pangani mankhwala osiyanasiyana, amodzi mwa awa ndi Amaryl. Ndemanga za kumwa mankhwala nthawi zambiri zimakhala zabwino. Chachikulu ndikuwonetsetsa kuti mulingo ndi nthawi yokwanira. Werengani zambiri za mankhwalawa munkhaniyi.

The zikuchokera mankhwala, kumasulidwa mawonekedwe

Amaryl imapangidwa ngati mapiritsi, omwe amatha kukhala ndi Mlingo wosiyana, womwe ndi 1, 2, 3, 4 mg.

Zomwe zimagwira pano ndi glimepiride, ndipo zinthu zothandizira zimaphatikizapo lactose monohydrate, magnesium stearate, microcrystalline cellulose, utoto wa E132 ndi E172, povidone.

Piritsi lirilonse limakhala ndi mzere wogawaniza, komanso lolemba. Phukusili lili ndi matuza awiri momwe muli mapiritsi 15.

Mapiritsi osiyanasiyana a mankhwalawa ndiosavuta kusiyanasiyana chifukwa cha mitundu yosiyanasiyana. Mapiritsi okhala ndi yogwira 1 mg pinki, 2 mg wobiriwira, 3 mg chikasu, 4 mg buluu.

Ndemanga zamankhwala Amaryl

Zokhudza mankhwala Amaril, ndemanga za anthu odwala matenda ashuga ndi zabwino. Odwala omwe Amaryl amakhulupirira kuti mankhwalawa amalimbana ndi shuga wamkulu wambiri matenda a shuga.

Chachikulu ndikusankha kuchuluka kwa mankhwalawa. Mbali yabwino ndilinso yosiyanasiyana ya mapiritsi, omwe amagwiritsidwa ntchito mosiyanasiyana. Izi zimakuthandizani kuti musasokoneze yoyenera.

Komabe, pali malingaliro ambiri olakwika, makamaka omwe amaphatikizidwa ndi kupezeka pafupipafupi kwa zotsatira zoyipa, monga kunjenjemera, kufooka, chizungulire, kunjenjemera m'thupi, kuchuluka kwa chilimbikitso. Pali zochitika za hypoglycemia, motero ndikofunikira kunyamula maswiti kapena zinthu zina zomwe zimakhala ndi shuga wambiri.

Ndemanga zolakwika zitha kumvekanso kuchokera kwa madalaivala omwe akutenga Amaryl. Mankhwalawa amakhudza mphamvu yamanjenje, chifukwa chake zimachepa, zomwe zimakhala zowopsa poyendetsa. Kuphatikiza apo, ngakhale kuti mankhwalawo amagwira bwino ntchito, mtengo wake umakhala wokwera kwambiri kuposa ma analogues.

Ndemanga ya Amaril:

Chifukwa chake, matenda ashuga nthawi zonse samayambitsa zovuta zambiri komanso kusasangalala. Mankhwala amtundu wa Amaril amatha kukhala ndi shuga wamba.

Amaryl wa matenda ashuga

Amaril adayikidwa ndi endocrinologist wokhala ndi shuga wambiri, komanso wopezeka ndi matenda a shuga a 2.

Mu kapangidwe kazinthu zingapo za glimepiride:

Mapiritsi apinki ali ndi 1 g yogwiritsira ntchito,
Mitundu - 2 g,
Wachikasu - 3g,
Buluu - 4 g

Kuphatikiza apo, kuyika chizindikiro kumayikidwa phukusi. Kuphatikiza pa glimepiroid, kapangidwe kameneka kamakhala ndi lactose, sodium starch, microcrystalline cellulose ndi polyvidion, komanso utoto wofanana ndi kalembedwe kamankhwala.

Zinthu zonse zomwe zimapangidwa ndizoyenera kugwiritsidwa ntchito mtundu 2 wa shuga mumankhwala omwe ali piritsi.

Fomu yotulutsira ndi miyala, dzina ladziko lonse ndi Glimepiride, mtengo wa Amaril uyambira pa 617 rubles.

Mfundo yogwira ntchito

Ichi ndi mankhwala omwe mumachita kawiri konse:

Imathandizira kupanga insulin yanu ndi kapamba.
Imachepetsa kukana kwa insulini ndipo imachepetsa kukhudzana ndi shuga.

Amaryl adapangidwa ngati njira ina yosagwiritsira ntchito mankhwala otsika mtengo omwe ali ndi chiwopsezo chachikulu cha hypoglycemia. Chifukwa cha zomwe zimagwira, zimapangitsa kuti kapamba kuti atulutse insulin mu Mlingo wochepa. Chiwopsezo chimawonjezeka ndi mlingo woyenera, kapena mlingo waukulu wa mankhwalawo.

Amaryl imakhala ndi antithrombotic ndi antacidosis, imalepheretsa neoglucogenesis m'chiwindi, ndikuwongolera lipogenesis ndi glycogeneis.

Kugwirizana

Amaryl imawonjezera mphamvu ya mankhwala onse omwe amachepetsa shuga. Sikulimbikitsidwa kuwonjezera zakudya zilizonse zanthawi yomweyo ndi zomwe mungachite.

Amaril amathandizidwa ndi anabolic steroids, Mao inhibitors, fluoxetine, tetracyclines ndi sulfonamides, komanso phenfluramine.

Mankhwala othandizira, othandizira osiyanasiyana, mahomoni a chithokomiro, adrenaline, glucagon ndi thiazide diuretics amachepetsa mphamvu ya mankhwalawa.

Palibe chidziwitso chasayansi chokhudza mowa wopanda mowa ndi Amaril.

Zovuta zotsutsana ndi zakumwa zoledzeretsa zimachitika chifukwa chakuti Amaril amalimbikitsa poizoni ndipo amatha kupweteka zilonda zam'mimba komanso magazi. Pakakhala chizungulire, tinnitus ndi zizindikiro zina zapoizoni atamwa mowa, amayitanitsa ambulansi, kutsuka m'mimba, kutenga ufiti, kenako ndikutsatira ndondomeko ya chithandizo.

Momwe mungachepetse Mlingo ndi kusiya mankhwala

Kudziletsa pakokha sikuloledwa. Dokotala amayenera kuwunika kuchuluka kwa shuga m'magazi, achite kafukufuku wa kapamba, ndikuwunika magawo onse a thanzi la wodwalayo.

Kuchotsa wodwala sikuyenera kuchitika mwanjira iliyonse. Kuchepetsa Mlingo, kusankha mankhwala ena - pokhapokha malinga ndi malangizo a dokotala.