Thioctacid 600 t: malangizo ogwiritsira ntchito

Mbale 1 yankho lili ndi:

Zogwira ntchito: 952.3 mg wa trometamol mchere wa thioctic acid (malinga ndi thioctic (a-lipoic acid) - 600.0 mg).

Othandizira: trometamol, madzi a jakisoni.

Transparent chikasu.

Zotsatira za pharmacological

Alfa-lipoic (thioctic) acid ndi chinthu chokhala ngati vitamini wokhala ndi katundu wa coenzyme. Amapangidwa m'thupi nthawi ya oxidative decarboxylation ya alpha-keto acid.

Mu shuga mellitus chifukwa cha hyperglycemia, zomwe zimakhala zomaliza glycosylation zimachulukirachulukira. Izi zimatsogolera kuchepa kwa kayendedwe ka magazi a endoneural ndi chitukuko cha endoneural hypoxia. Nthawi yomweyo, komanso kuwonjezeka kwa mapangidwe a ma free radicals, zomwe antioxidants, makamaka, glutathione, zimachepa.

Alfa-lipoic (thioctic) acid ndi chinthu chokhala ngati vitamini wokhala ndi katundu wa coenzyme. Mu thupi, imapangidwa nthawi ya oxidative decarboxylation ya alpha-keto acid.

Mu shuga mellitus chifukwa cha hyperglycemia, zomwe zimakhala zomaliza glycosylation zimachulukirachulukira. Izi zimatsogolera kuchepa kwa kayendedwe ka magazi a endoneural ndi chitukuko cha endoneural hypoxia. Nthawi yomweyo, komanso kuwonjezeka kwa mapangidwe a ma free radicals, zomwe antioxidants, makamaka, glutathione, zimachepa.

M'maphunziro oyesera omwe amapangidwa pa makoswe, adawonetsedwa kuti alpha-lipoic acid amachepetsa mapangidwe a mankhwala a glycosylation, kusintha magazi otuluka, ndikuwonjezera milingo ya glutathione. Izi zimawonetsera kuti alpha lipoic acid imathandizira kukonza ntchito ya mitsempha. Izi zimagwira ntchito pazovuta zamatenda a matenda ashuga polyneuropathy, monga dysesthesia, paresthesia (kuwotcha, kupweteka, dzanzi, kumva kuwawa). M'mayesero azachipatala odwala omwe ali ndi matenda ashuga polyneuropathy, kuperekera kwa alpha-lipoic acid kwatsitsa kuchepa kwa zovuta zam'maganizo zomwe zimayendera limodzi ndi matenda ashuga polyneuropathy (kupweteka, paresthesia, dysesthesia, dzanzi).

Mimba komanso kuyamwa

Zambiri zomwe zikupezeka pa za poizoni pakubala sizimapereka mwayi wofotokoza zovuta zakutsogolo kwa mwana wosabadwayo. Chifukwa cha kusowa kwa chidziwitso chokwanira chachipatala, mankhwalawa saloledwa kwa amayi panthawi yomwe ali ndi pakati.

Sizikudziwika ngati asidi wa thioctic (a-lipoic) amadutsa mkaka wa m'mawere. Ngati kuli kofunikira kugwiritsa ntchito mankhwalawa panthawi yoyamwitsa, kuyamwitsa kuyenera kutha.

Mlingo ndi makonzedwe

Mlingo wa tsiku ndi tsiku kumayambiriro kwa chithandizo chazovuta kwambiri zamatenda a matenda ashuga polyneuropathy ndi 1 ampoule wa Thioctacid 600 T (womwe umafanana ndi 600 mg wa thioctic acid) kwa masabata 2-4.

Thioctacid 600 T ungagwiritsidwe ntchito ngati kulowetsedwa mu isotonic sodium chloride solution (kulowetsedwa voliyumu 100-250 ml) kwa mphindi 30. Kuwongolera kwa mtsempha kuyenera kuchitika pang'onopang'ono (osathamanga kuposa 50 mg ya thioctic acid, i.e. 2 ml ya yankho la Thioctacid 600 T pamphindi). Kuphatikiza apo, intravenous ya unilated solution imatheka ndi jakisoni kapena syringe. Potere, nthawi yoyendetsera iyenera kukhala osachepera mphindi 12.

Ndondomeko ya kulowetsedwa

Chifukwa cha chidwi cha ntchito yogwira ntchito kuti iunikire, ma ampoules ayenera kuchotsedwa pamatatoni okhawo nthawi yomweyo asanagwiritse ntchito. Mwanjira yosungunulira njira ya kulowetsedwa kwa Thioctacid 600 T, gwiritsani ntchito yankho la isotonic sodium chloride. Njira yothetsera imayenera kutetezedwa ku kuwala (mwachitsanzo, mu foil ya aluminium). Njira yothetsera kulowetsedwa, yotetezedwa ku kuwala, ndioyenera maola 6.

Pambuyo pake, amasintha kukonzanso mankhwala omwe ali ndi mitundu ya a-lipoic acid pamlomo wowonjezera pa 300-600 mg patsiku.

Njira yothandizira odwala matenda ashuga polyneuropathy ndiyo njira yoyenera yothandizira odwala matenda ashuga.

Bongo

Pakakhala vuto la bongo, nseru, kusanza, ndi mutu. Atamwa mwangozi kapena mwadala (kufuna kudzipha) wa alpha-lipoic acid mu kumwa kwa 10 mpaka 40 g ndi mowa, kuledzera kwambiri kumawonedwa, nthawi zina kumatha kupha. Zizindikiro zamankhwala zoledzeretsa zimayamba kuoneka ngati zododometsa kapena zosokoneza, mtsogolomo nthawi zambiri zimayendetsedwa ndi kukomoka kwakukulu komanso kukula kwa lactic acidosis. Kuphatikiza apo, chifukwa cha kuledzera ndi milingo yayikulu ya alpha-lipoic acid, hypoglycemia, kugwedeza, rhabdomyolysis, hemolysis, kufalitsa intravascular coagulation (DIC), kuponderezedwa kwa ntchito yopyoza mafupa komanso kufooka kwamankhwala angapo.

Ngakhale atakayikira pang'ono za kuledzera, Thioctacid amawonetsa kugonekedwa kuchipatala mwachangu ndi njira zochizira zochotseredwa. Mankhwalawa akukomoka mwamphamvu, lactic acidosis ndi zovuta zina zonse zowopsa za kuledzera, chithandizo chamankhwala ndichofunikira. Mpaka pano, kuchuluka kwa hemodialysis ndi njira zowonjezera detoxization kutiathandizire kutulutsa kwa alpha-lipoic acid sikunatsimikizike.

Kuchita ndi mankhwala ena

Ndi makonzedwe apakati a Thioctacid 600 T, kuchepa kwa mphamvu ya chisplatin kumadziwika. Thioctacid 600 T imamanga chitsulacho ndi zokonzekera zomwe zimakhala ndi zitsulo (mwachitsanzo, chitsulo, magnesium, zopangidwa ndi calcium mkaka).

Pogwiritsa ntchito munthawi yomweyo, mphamvu yochepetsera shuga ya mankhwala a insulin ndi antidiabetesic yothandizira pakamwa imatha kupititsidwa patsogolo, chifukwa chake, kuwunika pafupipafupi kuchuluka kwa shuga m'magazi, makamaka kumayambiriro kwa mankhwala ndi Thioctacid 600 T, ndikulimbikitsidwa. m'mwazi).

Alpha lipoic acid imakhudzidwa mu vitro ndi ma ionic zitsulo maofesi (mwachitsanzo, cisplatin). Alpha-lipoic acid amapanga zovuta kusungunuka bwino ndi mamolekyulu a shuga. Thioctacid 600 T siyogwirizana ndi mayankho a dextrose, yankho la Ringer, komanso ndi mayankho omwe amachitika ndi disulfide kapena magulu a SH.

Monga zosungunulira za mankhwala a Thioctacid 600 T, njira yokhayo ya isotonic sodium chloride ingagwiritsidwe ntchito.

Njira zopewera kupewa ngozi

Kuledzera kwakumwa kosalekeza kumabweretsa chiwopsezo cha polyneuropathy ndipo kumachepetsa mphamvu ya Thioctacid 600 T. Chifukwa chake, odwala amalangizidwa kuti asamwe zakumwa zoledzeretsa panthawi yonse ya mankhwalawa komanso munthawi yakunja.

Mothandizidwa ndi kukonzekera kwa a-lipoic acid, makonzedwe a hypersensitivity adalembedwa, kuphatikizapo anaphylactic mantha (onani gawo "Zotsatira zoyipa"). Pa chithandizo, kuyang'anira wodwalayo ndikofunikira. Ngati zizindikiro (monga, kuyabwa, nseru, malaise, ndi zina zotere), kuyamwa kwa mankhwalawa kuyenera kuyimitsidwa nthawi yomweyo ndikuwonjezera mankhwala ngati pakufunika kutero.

Mukatha kugwiritsa ntchito mankhwala a Thioctacid 600 T, kusintha kwa fungo la mkodzo ndikotheka, komwe kumakhala kopanda tanthauzo.