Fomu ndi mankhwala osokoneza bongo a kalasi ya Biguanide

Mbuzi Zotsatsira Galega officinalis ) ogwiritsidwa ntchito pochiza matenda a shuga m'mankhwala achikhalidwe ku Europe. Cholinga chogwiritsa ntchito kuchotsa ndikuti mkodzo unayamba kuchepa (kuchepa kwa glucose mu mkodzo). Kumapeto kwa zaka za m'ma 1800, isoamylene-guanidine adapezeka akupanga. Mu 1918, zidatsimikiziridwa mwasayansi kuti guanidine ali ndi zochita za hypoglycemic mu nyama. Nthawi yomweyo, inali ndi poizoni.

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Fomu ndi mankhwala osokoneza bongo a kalasi ya Biguanide

Malangizo a formethine ogwiritsira ntchito amadziwika kuti ndi mankhwala othandizira odwala omwe ali ndi vuto la Biguanide. Chilendo cha mankhwalawa ndizogwiritsidwa ntchito mosiyanasiyana: mapiritsi angagwiritsidwe ntchito pochiza matenda amishuga a 2, tengani Foromu ndi omwe mtundu wawo wanenepa kwambiri samalola kuti muchepetse thupi kokha kudzera mu zakudya komanso masewera.

Ambiri odwala matenda ashuga amaloleza chithandizo mosavuta, zotsatira zosayenerera zimachitika mosavuta ngati malangizo ndi malamulo operekedwa ndi adotolo sanatsatidwe. Mtundu wa malangizo omwe ali patsamba lino amasinthidwa, amathandizidwa ndi owunika ndi ndemanga. Ndikosatheka kuzimva ngati chitsogozo chodzidzipangira nokha.

Mlingo wa Mlingo ndi malo osungira

Kunja, mankhwalawa amawoneka ngati piritsi loyera loyimbira loyera lokhala ndi mzere wogawika wopanda kukoma kapena kununkhira kwapadera. Mapiritsiwo amakhala ndi matuza, mu bokosi pamakhala zidutswa 10 kapena 12 za mitundu yosiyanasiyana: 0,5 g, 0,85 g kapena 1 g iliyonse. Amapangidwa kuti azigwiritsa ntchito pakamwa.

Mankhwalawa safuna mikhalidwe yapadera kuti asungidwe. Pamtunda wofunda (+ 25 ° C) kutali ndi kuwala kowala ndi chidwi cha ana, Fomu likhoza kusungidwa kwa zaka 2 - moyo wa alumali ukusonyezedwa phukusi. M'tsogolomu, mankhwalawa ayenera kutayidwa.

Limagwirira a zochita za formin

Gawo loyambirira la mankhwala ndi metformin hydrochloride. Kuphatikiza pazogwira ntchito, palinso zokopa zomwe zimapangidwa: magnesium stearate, croscarmellose sodium, povidone.

Mphamvu za Formetin, zomwe chithunzi chake chitha kuwonekera m'gawoli, ndizambiri:

Lowers glycemia
Kuchulukitsa chidwi cha insulin,
Imalepheretsa mayamwidwe a shuga,
Ilamulira kagayidwe ka lipid:
Sichimupangitse kulemera.

Mankhwala samathandizira kupanga insulin ya insulin, ma β-cell a kapamba, omwe amachititsa kuti pakhale kapangidwe kake, osadzaza. Metformin imatengedwa mwachangu: nsonga ya kuchuluka kwake imawonedwa patatha maola awiri.

Ubwino wina wa metformin ndi kuyanjana kochepa ndi mapuloteni amwazi. Formetin siyabwino pakukula kwa hypoglycemia. Gawo lolimbikira limadziunjikira mu minofu, impso, chiwindi, tiziwalo timene timagwira. Imapukutidwa makamaka ndi impso. Kuwunika kwa metformin kumatheka pokhapokha ndikuwonetsa matenda a impso. Pambuyo pa ola limodzi ndi theka, kumasulidwa kwa chinthu chogwira ntchito ndi mkodzo kumayamba.

Popeza mankhwalawa ali ndi katundu wowonjezera pamtundu wa genitourinary, mawonekedwe a impso ndi matenda ashuga amayenera kuwunikiridwa kawiri pachaka.

Ngati myalgia akukayikira, kupezeka kwa lactate m'mayesero amwazi kuyenera kuwunikidwa.

Momwe mungamwere mapiritsi

Mlingo wa tsiku ndi tsiku wa mankhwalawo nthawi zambiri amagawika pawiri. Malingaliro olondola kwambiri amakonzedwa ndi adokotala. Chithandizo chimayamba ndi Mlingo wochepa (0.5-0.85 g / tsiku), kamodzi pa sabata endocrinologist amatha kusintha mlingo kutengera zotsatira za kuyezetsa magazi. Mulingo woyenera ndi 3 ma PC / tsiku.

Metformin nthawi zambiri imatengedwa mphindi 20 asanadye. Kenako magawo azakudya ndi mankhwala amanjana.

Kudumpha zakudya mukatha kumwa mankhwalawa ndizowopsa: mutha kuyambitsa shuga.

Forimetin imatengedwa momasuka ndi odwala matenda ashuga omwe amayendetsa kayendedwe kazinthu zovuta, chifukwa sizimayambitsa zotsatira zosasangalatsa zomwe zimachepetsa chidwi komanso kuthamanga kwa zomwe zimachitika.

Pazovuta zovuta, zovuta zimatha, chifukwa chake, mfundo zoterezi zimayenera kufotokozedwa ndi endocrinologist.

Metformin yochepetsa kulemera: momwe mungatengere komanso kuchita bwino: malangizo ogwiritsira ntchito ndi kuwunikira, Mokwanira zaumoyo pa iLive

Mwa mapiritsi ambiri azakudya, Metformin imatha kusiyanitsidwa. Chida ichi, pogwiritsa ntchito pafupipafupi, chimatha kuchepetsa kwambiri thupi.

Metformin imawonetsedwa kwa odwala omwe ali ndi matenda ashuga, koma anthu onenepa kwambiri amatha kuchepa thupi pomwa mankhwalawa.

Mankhwala Metformin amapezeka mwa mawonekedwe a mapiritsi a pakamwa. Mapaketi ali ndi mapiritsi 30, 50, 60, 120, zonse zimatengera dziko lakapangidwe.

Zomwe zimagwiritsa ntchito mankhwalawa ndi metformin. Mankhwala zochita zam'mapiritsi ndi hypoglycemic.

Zochita za Metformin pa thupi:

Zakudya zomanga thupi zimakonzedwa mwachangu, zomwe zimapangitsa kuchepetsa thupi,
Kuchulukitsa kuchuluka kwa oxidation wamafuta acids,
Imachepetsa kuyamwa kwamatumbo,
Sizimathandizira kupanga insulini, yomwe imachepetsa kumverera kwanjala,
Amachepetsa shuga.

Komabe, musanamwe mapiritsi, ndikofunikira kuti muphunzire mosamala zonse za mankhwalawa.

Ndizotheka kuchepetsa kulemera ndi Metformin pokhapokha ngati insulin yokwanira ipangidwa m'thupi. Kugwiritsa ntchito shuga sikungachedwetse kuchuluka kwa mafuta m'magazi, chifukwa cha kuchuluka kwa shuga ndi chiwindi mukamamwa mankhwalawa.

Ndiye, momwe mungatenge Metformin kuti muchepetse kunenepa? Kuti zotsatira za kumwa mankhwalawa zikhale zabwino, komanso mapiritsiwo palibe vuto, muyenera kutsatira malangizo a madokotala.

Simungathe kumwa mapiritsiwa kwa masiku opitilira 22, ndipo mlingo wa tsiku ndi tsiku sayenera kupitirira 1500 mg.

Malamulo owonjezerawa kutenga Metformin, kutsatira zomwe zingapangitse kuti muchepetse kuwonda:

Mukamamwa mapiritsiwa, kuchita masewera olimbitsa thupi ndikofunikira,
Maziko azakudya ayenera kukhala zopepuka komanso zopepuka m'mimba,
Imwani madzi ambiri
Dzichepetsani pakudya.

Aliyense amadziwa zinthu zomwe zimalimbikitsa kulemera msanga. Mafuta ndi pasitala, mpunga, mbatata, nyama yamafuta, mpunga ndi mowa ziyenera kukhala zochepa monga momwe mungathere.

Dokotala iyemwini amapereka mtundu weniweni wa Metformin kwa wodwala aliyense payekhapayekha. Anthu omwe si onenepa kwambiri, koma amakonda kunenepa kwambiri, amatha kumwa mapiritsi okhala ndi 200 mg, ndipo katswiri wazonenepa amapatsa mpaka 1500 mg patsiku.

Ndizotheka kuchepetsa thupi mothandizidwa ndi Metformin, koma mulimonsemo muyenera kudzipatula pakudya. Mukamamwa mankhwalawa, kulemera kumachepa. Ziwerengero zakuchepera zimatha kufika 15 kg.

Tiyenera kukumbukira kuti simungathe kuchepetsa thupi kwakanthawi kochepa, izi ndizovuta zamthupi, motero makilogalamu 5-6 m'masiku 22 ndizotsatira zabwinobwino.

Monga mankhwala aliwonse, Metformin imakhala ndi zotsutsana zingapo kuti mugwiritse ntchito komanso mavuto. Muyenera kuphunzira nkhaniyi mosamala musanamwe mapiritsi.

Anthu omwe ali ndi zotsutsana ndi Metformin:

Amayi oyembekezera komanso oyembekezera
Ndi ngozi yoopsa kwambiri yam'madzi.
Kuvutika ndi matenda a impso, chiwindi, kupuma komanso mtima,
Mowa
Odwala omwe ali ndi matenda a shuga omwe ali ndi vuto lalikulu laukoma kapena makolo.

Musaiwale kuti thupi la aliyense ndiwopadera ndipo limatha kugwirira ntchito molakwika mankhwala osadziwika. Hypersensitivity pamapiritsi aliwonse angachitike mosayembekezereka, ndikofunikira kuganizira izi musanamwe mapiritsi osayang'aniridwa ndi adokotala.

Zotsatira zoyipa zimatha kukhala zofatsa koma osamvetsetsa kwa nthawi yayitali, koma nthawi zina vutoli limatenga nthawi yayitali ndipo limafunikira kufunsa dokotala. Pakachitika vuto loti thupi litenge mapiritsi, muyenera kusiya kumwa.

Kusanza ndi kusanza
Kupweteka kwam'mimba komanso kutsegula m'mimba
Kuchepa kapena kusowa kwa chakudya,
Tizilombo tating'ono tambiri thupi,
Kulawa kwazitsulo pakamwa
Lactic acid chikomokere (chakupha ndi chosowa).

Musanatenge Metformin, ndikofunikira kuuza adotolo za zovuta zonse zomwe zilipo, matenda osachiritsika komanso otupa pokambirana ndi adokotala. Kubisika kwa chidziwitso chofunikachi kumatha kubweretsa zotsatira zoyipa.

Mtengo wa Metformin ukhoza kukhala wosiyana. M'mafakitala mumapezeka mankhwala osokoneza bongo ku rubles 50-3000. Zosankha zamapiritsi a mankhwalawa. Dokotala adzalembera mankhwala omwe wodwala aliyense payekhapayekha, akuganizira thanzi lake ndi zina zake.

Misonyezo ya mankhwalawa imapezeka kulikonse, koma mtengo wawo umakhala wokwera. Zotsatira za analogues ndi Metformin ndizofanana, koma mtengo wake ndi wosiyana. Bwanji mulipire ndalama zambiri ngati mungathe kugula zotsika mtengo.

Ndipo apa mupeza mndandanda wazinthu zothandiza kuchepetsa kuwonda zomwe zimagulitsidwa ku pharmacy. Komabe, samalani ndikumwa mankhwala; funsani dokotala.

Werengani za maubwino ndi zopweteketsa za kuchulukitsidwa kwa njuchi pano. Zinafika poti amatha kuchiza matenda osiyanasiyana.

Mankhwala onse opangidwa pofuna kuchiza matendawa sayenera kumwa chifukwa china. Thupi laumunthu limagwira ntchito mgoli ina ndipo simungathe kuthyola ngati mukufuna kuchepetsa thupi. Lero mutha kupeza zambiri zokhudzana ndi kuchepa thupi, koma simungakhulupirire.

Kuphatikiza apo, kuti muchepetse thupi mothandizidwa ndi Metformin, muyenera kuyesetsa mwamphamvu, kungomwa mapiritsiwo sikungasiye kulemera, chifukwa chake dziikeni pangozi ngati zingatheke kuchotsa mapaundi ena mwachilengedwe.

Boris Anatolyevich, endocrinologist

Monga dokotala, ndikukhulupirira kuti muyenera kuchepa thupi pang'onopang'ono komanso popanda mapiritsi. Metformin imatha kuthandizira kuchepa thupi, koma pali zovuta zambiri komanso zotsutsana. Anthu, atawerenga pa intaneti za kuthekera kwa Metformin kuwotcha mafuta, adathamangira kukamwa iwo osaphunzirapo zambiri.

Kuthekera kokuvulaza thupi lanu ndizokwera kwambiri kuposa kuthekera kochepa thupi. Mapeto ake, iwo amene akufuna kuchepa thupi ayenera kumvetsetsa kuti izi sizingatheke popanda zoletsa chakudya, ndipo kuchita masewera olimbitsa thupi ndikofunikira. Metformin si malo opha anthu onenepa kwambiri.

Mankhwalawa adandilamula ndi adotolo, chifukwa shuga wanga m'thupi mwanga adakulirakulira. Ndikufuna kunena kuti momwe zimatengera izi zidadabwitsa ine. Ndinayamba kumva bwino, koposa zonse, ndinali wonenepa kwambiri. Ndataya 5 kg ndipo ndine wokondwa kwambiri. Zimakhala zokhumudwitsa pang'ono kuti ndimakhala ndi vuto logaya chakudya nthawi zonse, koma ndingatani.

Atsikana, ndinayesetsa kumwa Metformin kuti muchepetse thupi. Kulemera kunakhala pafupifupi malo, ndipo kupweteka kwa mutu ndi mseru kunandikuta kwa nthawi yayitali. Sindinadye, mwina ndichifukwa chake sizinandithandizire.

Anandiika kuchipatala. Ndinkamwa kwa mwezi umodzi ndipo sindinazindikire kuti ndataya 8 kg. Poyamba sindinamvetsetse zomwe zinachitika, kenako ndinawerenga. Mwinanso kudya kwanga kunakhudzanso, ndinakusintha, monga shuga inayamba kutuluka. Mwambiri, ndimakondwera ndi zotsatira zake.

Ndipo ndidayamba kumwa Metformin makamaka kuti ndichepetse thupi. Pambuyo pake, ndidaphunzira malingaliro onse pa intaneti. Ndakhala ndikumwa mapiritsi kwa masiku 20, ndikuphunzira masewera olimbitsa thupi komanso kudya zakudya zopanda zakudya, ndinataya makilogalamu 9 panthawiyi. Zachidziwikire pali zovuta, koma muyenera kuyesetsa kwambiri. Pakapita kanthawi ndibwereza maphunzirowo.

Ndayesa mapiritsi ambiri azakudya ndipo ndikuganiza kuti Metformin siinasinthe ndi ena onse. Ndinkamwa kwa pafupifupi mwezi umodzi ndipo sindinachepetse kwambiri thupi; Ndinkadya pafupipafupi komanso sindinkachita masewera olimbitsa thupi, mwina zinkandikhudza.

Anandiika metformin (Glucofage) ndi endocrinologist kuti achepetse thupi komanso matenda a metabolism (anayika matenda a metabolic), ndinaperekanso malangizo pazakudya. Mankhwalawa adathetsa zovuta zakuphwanya, ndipo ndidakwanitsa kuchepetsa thupi ndi ma kilogalamu 9.

Metoformin 500 adayamba kumwa ndipo chopondacho nthawi yomweyo chidakwiya. Izi zikapitiliza, ziyenera kuyimitsidwa! Zachidziwikire kuti muchepetsa thupi ndikuphwanya matumbo.

Fomu yothetsera kuwonda - ndemanga - Journal of zakudya ndi kuwonda

Mankhwala olimbana ndi kunenepa kwambiri operekedwa ndi makampani opanga mankhwala masiku ano ali osiyanasiyana. Koma ambiri aiwo ali ndi zinthu monga metformin. Kuphatikizira, kutengera icho, chopangidwa chotchedwa Formmetin chimapangidwa.

Mwakutero, siyosiyana kwambiri ndi mankhwala ena okhala ndi metformin. Komabe, chochitika chenicheni cha chinthu choterocho ndichoyenera kudziwa mwatsatanetsatane.

Kenako zimveka bwino ngati ndizoyenera kugwiritsa ntchito pochepetsa thupi, kapena ngati ndibwino kusankha njira ina.

Forminein yochepetsa thupi - mawonekedwe amachitidwe

Choyamba, ndikofunikira kuzindikira kuti Forthine sanapangidwe poyambirira kuti athetse thupi lolemera. Koma amachepetsa kwambiri njira yobwera ndi chakudya chamafuta.

Nthawi zambiri mankhwalawa amagwira ntchito pama carbohydrate othamanga. Zotsatira zake, kuchuluka kwa shuga kumachepa, ndipo zochitika za pancreatic zimabwereranso.

Koma chifukwa chiyani zonsezi zimagwirizanitsidwa ndi kuchepa thupi? M'malo mwake, kulumikizana ndikulunjika.

Mothandizidwa ndi Formetin, mutha kupanga zinthu zomwe zimapangitsa kuti kuchepetsa thupi kuzikhala kosavuta komanso kosavuta. Ngakhale muyenera kutsatira zina zowonjezera. Kuti muchepetse kunenepa mukamamwa mapiritsi otere, muyenera kuganizira izi:

Siyani kugwiritsa ntchito zakudya zokhala ndi shuga,
chakudya chilichonse ayenera kuchepetsedwa
Kuti muchepetse kuchepa thupi, muyenera kudzipatsa zolimbitsa thupi.
Pambuyo masiku 20 motsatana, ayenera kupuma kwa mwezi umodzi.

Chifukwa chake, Forethine alibe chozizwitsa china chilichonse. Ndipo lonjezo loti "athetsa mafuta" ndiwongochenjera chabe.

Koma, komabe, ndizotheka kukwaniritsa kuchepetsa thupi pogwiritsa ntchito. Ndipo ndemanga zomwe zimaperekedwa pa Formetin kuti muchepetse thupi zimangotsimikizira izi.

Zikuwonekerabe kuti tanthauzo la kugwiritsa ntchito mapiritsiwo ndi liti kwenikweni. Kenako zotsatira zakuvomera kwawo ndizabwino kwambiri.

Kupanga ndi mawonekedwe a kumasulidwa

Malangizo ogwiritsira ntchito formin akuwonetsa kuti mankhwalawa amawagawa ngati mapiritsi omwe ali ndi mawonekedwe:

Mlingo wa ntchito

500 mg
850 mg
1 g

sodium croscarmellose,
magnesium wakuba,
sing'anga yam'mero povidone (polyvinylpyrrolidone).

Mankhwala

Mankhwala akuti Forthine amatanthauza ma hypoglycemic wothandizira (biguanides). Mapiritsiwo adapangira pakamwa. Mankhwala othandizira amathandizira kuchepetsa kuchuluka kwa chiwindi cha gluconeogeneis, kumathandizira kugwiritsidwa ntchito kwa glucose, ndikuwonjezera chidwi cha insulini m'thupi lathu. Mankhwalawa amagwira ntchito moyenera, popanda kupanga zochita za hypoglycemic, osakhudza kutulutsidwa kwa insulin ndi maselo a kapamba.

Ndi mankhwala othandizira, kuchuluka kwa ma triglycerides ndi lipoprotein m'magazi kumatsika. Formmetin imakhala ndi fibrinolytic, imathandizira kulemera kwa odwala omwe ali ndi matenda ashuga, ndipo imagwiritsidwa ntchito kuchepa thupi. Metformin imalowetsedwa m'mimba, imafikira kwambiri m'magazi pambuyo pa maola a 2,5, yowonetsedwa kudzera mu impso.

Mlingo ndi makonzedwe

Koyamba achire mlingo wa mankhwala pafupifupi 500-1000 mg / tsiku. Mlingo komanso kuchuluka kwa mankhwalawa kuyenera kukhazikitsidwa ndi adokotala atatha maphunziro, kuwunika momwe wodwalayo alili komanso kuopsa kwa matendawo. Kwa okalamba, mlingo waukulu wa tsiku ndi tsiku ndi 1 g ya mankhwala. Imwani mapiritsi ayenera kudya.

Malangizo apadera

Pa mankhwala ndi Formetin, malangizo analamula kuti aziona momwe magwiridwe amagwirira ntchito. Ndikulimbikitsidwa kuyeserera magazi kuti mupeze kuchuluka kwa glucose ndi creatinine. Mankhwalawa sakukhudza kuyendetsa magalimoto, makina owopsa. Ndi munthawi yomweyo makonzedwe a sulfonylurea, omwe ali ndi insulin, malangizowo akuwonetsa kusiya ntchito zomwe zikukhudza kuchuluka kwa ndende.

Kuyanjana kwa mankhwala

Kuphatikiza ndi mankhwala ena, formin ingayambitse zotsatira zosafunikira. Malangizo ogwiritsidwira ntchito samalimbikitsidwa kuphatikiza mankhwalawa ndi awa:

Cimetidine - mankhwala omwe amachepetsa kuchoka kwa metformin m'thupi.
Chlorpromazine - Kuphatikiza kumawonjezera mwayi wokhala ndi glycemia.
Danazole - metformin imathandizira mphamvu ya hyperglycemic ya mankhwala.
Maanticoagulants (omwe amapezeka mu coumarin) - zinthu zomwe zimapangidwa ndi Formetin zimachepetsa kugwira ntchito kwawo.
Njira zakulera za pakamwa, mahomoni a chithokomiro, zochokera ku phenothiazine, nicotinic acid, diuretics ya glucagon - zinthu zimafooketsa mphamvu yothandizidwa ndi metformin.
Acarbase, clofibrate zotumphukira, sulfonylureas, mankhwala osokoneza bongo a anti-yotupa, angiotensin kutembenuza ma enzyme inhibitors, monoamine oxidase, β-blockers, oxytetracycline - mankhwalawa amawonjezera mphamvu ya formin.
Ma antipsychotic - ngati ndi kotheka, mlingo wophatikizika umafunika kusintha kwa metformin.

Zotsatira zoyipa ndi bongo

Ngati muyezo wa mankhwalawo watchulidwa mu malangizo, ukadwala, wodwalayo amatha kukhala ndi lactic acidosis. Kuperewera kwa chithandizo chokwanira kumabweretsa imfa. Kumwa mankhwala kumatha kuyambitsa mavuto. Ndi zizindikiro zazikulu, madokotala amatipatsa antispasmodics, antacid. Malinga ndi malangizo ogwiritsira ntchito, pali ngozi ya:

kusanza, kusanza,
kuchepa kapena kusowa kwa chakudya,
zotupa pakhungu
kupweteka kwam'mimba, kusefukira,
kutsegula m'mimba
kuchepa magazi
achina,
lactic acidosis,
hypovitaminosis B12.

Contraindication

Malangizo ogwiritsira ntchito Fetetin amatsata kupatula kugwiritsa ntchito mankhwalawa masiku awiri asanafike komanso atayesedwa ndi radioisotope kapena X-ray. Simungathe kupereka mankhwala kwa anthu opitilira zaka 60 omwe akugwira ntchito yolemetsa. Formetin ilinso ndi zotsutsana zingapo:

mimba ndi mkaka wa m`mawere
uchidakwa wambiri, mankhwala a ethanol
acidosis
Hypersensitivity pazogulitsa,
Zakudya zochepa zopatsa mphamvu
ntchito kwa chiwindi, impso,
mankhwala a insulin pambuyo pakuvulala, chithandizo cha opaleshoni,
matenda ashuga ketoacidosis,
Matenda opatsirana omwe amakhumudwitsa minofu hypoxia (mtima, kupuma, magazi,)
matenda a shuga, wodwala.

Makampani ogulitsa mankhwala amapanga mankhwala omwe ali ofanana ndikupanga ndi mawonekedwe a formin. The fanizo la mankhwala ndi:

Ndani amalimbikitsidwa komanso pamene mankhwalawa apangika

Formetin adapangidwa kuti azilamulira matenda ashuga amtundu wa 2. Imakhala ndi jakisoni wa insulin pophatikiza mankhwalawa, angagwiritsidwe ntchito ngati mankhwala osinthika ngati zakudya zosinthika (zakudya zama carb ochepa, zochitika zolimbitsa thupi zokwanira) sizipereka zotsatira zomwe zikuyembekezeka.

Poyerekeza ndi ndemanga, formatein yochepetsa thupi imasonyezedwa mtundu wa kunenepa kwambiri wokhudzana ndi odwala matenda ashuga omwe ali ndi mtundu wachiwiri wa matenda, pomwe ma deposits amafuta amapezeka pazilonda zam'mimba, makamaka pamimba.

Kugwiritsa ntchito mankhwala akulu kukonza mawonekedwe a munthu wathanzi ndizowopsa.

Osagwiritsa ntchito mankhwalawa:

Ndi hypersensitivity pazomwe zimapangidwira,
Ngati chiopsezo cha lactic acidosis ndi chokwera kwambiri,
Ndi mavuto akulu a chiwindi,
Pankhani ya uchidakwa wambiri ndi mbiri yakumwa mowa,
Ngati pali matenda oyambitsidwa ndi matenda opatsirana,
Ngati wodwala matenda ashuga akudwala chakudya (mpaka 1000 kcal / tsiku),
Ndi ketoacidosis,
Matenda a impso komanso opweteka kwambiri,
Ngati wozunzidwayo ali ndi vuto kapena asanakumanepo nalo,
Pakakhala mbiri yamilandu yamtima, kuphwanya kwamitsempha yamagazi.

Ndi kupsa kwambiri, kuvulala kwambiri, musanayambe kuchita opaleshoni, wodwalayo amaperekanso insulin. Ngati chizindikiritso cha ayodini chikuyembekezeka kukhala ndi matenda ashuga, masiku awiri asanafike ndi masiku atatu atatha kuyesedwa, Formetin imathetsedwa.

Pokhala ndi zolephera, amagwiritsa ntchito Formetin kwa anthu opitilira 65, chifukwa impso ndi ziwalo zina zomwe zili ndi matenda akuluakulu a shuga sizili bwino, ndipo chiopsezo chokhala ndi lactic acidosis chikuwonjezeka.

Zotsatira zoyipa ndi bongo

Poyerekeza ndi ndemanga pamisonkhano yamtundu, formimetin odwala matenda ashuga amalolera bwino. Komabe, malangizowa ali ndi ziwonetsero zingapo za zomwe zingachitike ngati munthu ali ndi mankhwala osokoneza bongo kapena munthu payekha.

Matumbo. Nthawi zina (mu 3% ya milandu) kusokonezeka kwa dyspeptic, kuphwanya mtundu wa defecation, kusowa chilimbikitso, kupweteka kwa epigastrium amalembedwa.
Ziwengo Kuchita zimawonekera mu mawonekedwe a totupa (manja, chifuwa, masaya), kuyabwa ndi kuwonjezeka kumva khungu. Nthawi zina, kutentha thupi kumatha.
Dongosolo la Endocrine. Hypoglycemia imachitika pakakhala zovuta zina zamagulu ena omwe amalimbikitsa mphamvu za metformin, ndikusintha kwa muyezo wapamwamba ndi Mlingo wa formin.
Kupenda. Mwazowopsa, lactic acidosis imawonedwa - mkhalidwe wowopsa womwe umafuna kusiya mankhwala mwachangu ndi chithandizo chapadera.
Pogwiritsa ntchito metformin kwanthawi yayitali, mayamwidwe ake akuipiraipira, izi zimakhudzanso mavitamini B12 (mankhwala osokoneza bongo amatha).
Njira yozungulira. Pali zigawo (zosowa) za kuchepa kwa magazi m'thupi.

Malinga ndi ziwerengero, zotsatira zoyipa zimawonetsedwa nthawi yoyamba mankhwalawa, mpaka thupi litasintha. Pogwiritsa ntchito pafupipafupi mwezi umodzi, zizindikiro zambiri zimazimiririka osakonzanso njira ya mankhwalawo. Ndi zovuta zoyipa, adokotala amatha kukupatsani mankhwala antispasmodic kapena antacid.

Ngati mwangozi kapena mwadala mukulitsa mankhwalawo kangapo, zotsatirapo zake zimakhala zovuta (mpaka kufa). Lactic acidosis imathanso kuchitika ngati mulingo wawonetsedwa, ngati impso zakana kupukusa metabolites munthawi.

Zizindikiro zoyambirira za lactic acidosis:

Dontho lakuthwa la kuthamanga kwa magazi,
Myalgia
Thupi kapena kuzizira
Kuyenda kwamtima pang'ono
Kuperewera kwa mgwirizano
Kupuma pang'ono
Matenda a shuga.

Ngati pali zingapo mwazizindikiro zomwe zalembedwa, kugwiritsa ntchito mankhwalawa kumayimitsidwa, wogwidwayo amapatsidwa zotengera kuti atulutse m'mimba kuchokera kumayendedwe omwe sanapatsidwe mankhwalawo, ndipo amapempha thandizo kuchipatala. Panthawi yachipatala, hemodialysis imachitidwa, chothandizira cha mankhwala chimayikidwa.

Zotsatira Zogwiritsa Ntchito Mankhwala

Formmetin ndi mankhwala apadziko lonse: angagwiritsidwe ntchito monotherapy kapena kuphatikizidwa ndi mankhwala ena a hypoglycemic, kuphatikiza jakisoni wa insulin.

Koma nthawi zina, pochiza matenda othandizira, kuchira kwovuta kumatha kukhala ndi zotsatirapo zoyipa.

Ndi makonzedwe omwewo a Danazol, pali chiopsezo cha zotsatira za hypoglycemic, kotero mlingo wa mankhwalawo uyenera kuyang'aniridwa mosamalitsa kapena kusinthanitsa ndi analog.
Akaphatikizidwa ndi cimetidine, mawonekedwe a metformin amalephereka, kuchuluka kwake mthupi kumatha kupereka mphamvu yosagwirizana ndi hypoglycemic.
Kutha kwa coumarin kumachokera ku ziletsa metformin.
Mankhwala osakanikirana ndi carbazole, NSAIDs, clofibrate, insulin, ACE inhibitors, cytophosphamide, β-blockers, sulfonylureas, oxytetracycline amathandizira ntchito ya metformin.
Kuphatikiza komweko kwa glucagon, epinephrine, thiazide diuretics, mahomoni a chithokomiro amalepheretsa kugwira ntchito kwa formin.

Pogwiritsa ntchito njira zakulera zamkamwa, mayi ayenera kuuza mitundu ya mankhwalawo kwa endocrinologist kuti asinthe mlingo wa Formetin. Osam'patsa mankhwala komanso kuphatikiza ndi Nifedipine, womwe umakulitsa kuchuluka kwa metformin m'magazi, imathandizira kuyamwa kwake, imachepetsa kuchoka. Ngati pali vuto ndi impso, zotsatira zake zingayambitse kukomoka.

Ngati mankhwalawa adakhazikitsidwa ndi ethanol, kuphatikiza ndi metformin, chiopsezo cha lactic acidosis chimawonjezeka kwambiri.

Formetin - analogues

Gululi (mankhwala antidiabetesic mankhwala) komanso othandizira (metformin hydrochloride), mankhwalawa akutsatira: Metamine, Bagomet, NovoFormin, Fomu.

Malinga ndi mphamvu ya mankhwala a Formetin ndi ofanana:

Lymphomyozot,
Nyama,
Phuli
Levemir Flekspen,
Levemir Penfill,
Avandia

Kusankha kwina komwe kumachepetsa mankhwala ochepetsa shuga mumsika wamankhwala kumakhala kwakukulu, ngakhale katswiri ndizovuta kuyendera pamodzinso. Ndipo, odwala matenda ashuga kuyesa kwambiri thanzi lawo. Chifukwa chake, simuyenera kudalira malingaliro a oyandikana nawo kapena otsatsa pankhaniyi. Ndi dokotala yekhayo amene angasankhe bwino m'malo mwake, poganizira kuopsa kwa matendawa komanso thanzi lanu lonse.

Malingaliro a odwala matenda ashuga pa Formetin

About Fomu, ndemanga za anthu odwala matenda ashuga amasakanikirana. Iwo omwe amamwa mankhwalawo kwa nthawi yayitali, amadziwa zabwino zake. Oyamba kumene amadandaula za zotsatira zoyipa. Matenda a Dyspeptic amatha okha patapita milungu ingapo, ngati simukuyesa kuonana ndi dokotala. Ngakhale zoletsa za zaka zomwe zikuwonetsedwa mu malangizo ziyenera kukumbukiridwa.

Metformin yochokera kuformformin ndi mankhwala apakhomo okhala ndi umboni waukulu. Nthawi zambiri, makamaka ndi matenda a shuga a 2, palibenso njira ina yomwe ingapezeke chifukwa cha mankhwala a metformin. Chifukwa chake, musathamangire kuti mumvetsetse za kuyenera kwake, ndibwino kuthandiza thupi kuti lizolowera mankhwala ena mothandizidwa ndi kadyedwe, malingaliro oyenera azamankhwala komanso magwiridwe olimbitsa thupi oyenera. Popanda njira yotere, mankhwala omwe angokhala kumene sangakhale opanda ntchito.