Zolemba pamapiritsi a Trazent

Trazhenta ndi mankhwala a hypoglycemic omwe amalimbikitsidwa kuti azigwiritsidwa ntchito mkati. Chogulirachi chili ngati mawonekedwe ozungulira, mapiritsi ofiira owala omwe ali ndi mbali zam'mphepete mwa beveled. Kumbali ina ya piritsi ndi logo ya kampani, ndipo inayo, siginecha ya D5.

Chofunikira chachikulu cha mankhwalawa ndi 5 mg ya linagliptin, zigawo zothandizira za mankhwalawa ndi wowuma wa chimanga, mannitol, magnesium stearate, Copovidone, pregelatinized starch. Mutha kugula mankhwalawa m'matumba a aluminium mapiritsi 7 lililonse.

Mankhwala tikulimbikitsidwa kuti agwiritsidwe ntchito ndi mtundu wachiwiri wa matenda a shuga, chida ichi chidzakhala chimodzi chothandiza kwambiri ngati, motsutsana ndi zochitika zolimbitsa thupi zolimbitsa thupi komanso kudya, sizingatheke kuti shuga asungidwe bwino.

Mankhwalawa amayenera kufotokozedwa ngati wodwala matenda ashuga ali ndi mbiri yolephera Impso, Metformin akupatsirana kapena ngati munthu salola mankhwalawa. Zowoneka bwino zitha kugwiritsidwa ntchito limodzi ndi:

• zochokera sulfonylurea,
• Thokozani,
• Metformin.

Komanso, mankhwalawa amafunikira ngati chithandizo ndi mankhwalawa sichikulitsa thanzi la wodwalayo.

Trazenta mtengo wa mapiritsi 30 a 5 mg uzikhala ma ruble 1,500, mutha kuwugula m'mayendedwe apakompyuta ndi pa intaneti. Mankhwalawa adalowa mu radar (regista yamankhwala). Mndandanda wa mankhwalawa: Nesina, Onglisa, Yanuviya, Galvus, Komboglisa, analogues otsika mtengo pakadali pano.

Malangizo ogwiritsira ntchito mankhwalawa

Malangizowo akuwonetsa kuti mankhwalawa sayenera kuthandizidwa pa nthawi yoyembekezera, mtundu wa matenda ashuga 1, nthawi yoyamwitsa, ana osakwana zaka 18, ndi zomwe zimachitika chifukwa cha zinthu zina za mankhwala, ketoacidosis yoyambitsidwa ndi matenda a shuga.

Mlingo wokhazikika wodwala wamkulu ndi 5 mg, muyenera kumwa mankhwala katatu patsiku. Mankhwalawa akamwedwa ndi Metformin, mlingo wake umasinthidwa. Mankhwala kwa odwala mkhutu aimpso ntchito sikufuna kusintha.

Panthawi yophunzira za pharmacokinetics, zidapezeka kuti ndi zovuta za chiwindi, kuchuluka kwa zomwe mankhwalawa amatha kusintha, komabe, pakadali pano, palibe chidziwitso chokwanira ndi kugwiritsa ntchito mankhwalawa odwala matenda ashuga.

Palibe chifukwa chosinthira mlingo wa odwala okalamba, koma:

1. sikulimbikitsidwa kwa odwala omwe ali ndi zaka zopitilira 80 kuti amwe mankhwalawo, popeza palibe chochitika chachipatala,
2. kotero sizinakhazikikebe momwe chithandizocho chiliri chokwanira kwa ana ndi achinyamata

Wodwala matenda ashuga akatenga mankhwala a Trazent pafupipafupi komanso mwangozi akumanidwa ndi mlingo, ndikofunikira kumwa piritsi lotsatira posachedwa, koma mlingo wake sungawonjezeke. Mankhwalawa amatengedwa nthawi iliyonse, mosasamala chakudya.

Chithandizo chitha kuchitika malinga ndi njira zosiyanasiyana. Mapiritsi amagwiritsidwa ntchito ngati monotherapy kwa odwala matenda ashuga omwe ali ndi vuto losakwanira la glycemic motsutsana ndi maziko olimbitsa thupi odwala matenda ashuga, zolimbitsa thupi, ngati munthu salola Metformin, mankhwala omwewo.

Mankhwalawa atenga gawo limodzi la magawo awiri a mankhwala a Metformin, thiazolidatediones, sulfonylureas kuchokera pakadalibe zotsatira za monotherapy yotchedwa mankhwala, kusakwanira kwa zochitika zolimbitsa thupi komanso kudya.

Chidachi chimagwiritsidwa ntchito ngati mankhwala ophatikiza atatu ndi mitundu kuchokera ku Metformin. Dokotala amafotokozeranso mankhwala limodzi:

• jakisoni wa insulin
• Pagogazone
• zochokera sulfonylurea.

Mukatha kugwiritsa ntchito 5 mg ya mankhwala mkati, zinthu zomwe zimayamba kugwira ntchito zimayamba kuyamwa, mpaka zimafika pozama pambuyo pa maola 1.5. Ndendeyi idzachepa malinga ndi gawo la magawo atatu, theka la moyo limadutsa maola 100, chifukwa chokhazikika, chomangira cholimba cha linagliptin.

Kuthandiza kwa theka la moyo kuchokera ku thupi pambuyo pakupereka mankhwala mobwerezabwereza kumakhala maola 12.

Pakangogwiritsidwa ntchito kamodzi pa mankhwalawa, kukhazikika kwa thunthu kumawonedwa pambuyo pa mlingo wachitatu.

Mayanjano omwe angakhalepo ndi oloweza kwa Trazhenty

Analogue ndiyotsika mtengo kuchokera ku ma ruble 1538.

Glucophage ndi mtengo wotsika mtengo wa ku France womwe ungathenso kutumikiridwa pochizira mtundu wa 2 shuga mellitus (mu akulu), koma umasiyana ndipo umakhala ndi metformin mu mlingo wa 500 mpaka 1000 mg. Glucophage ingagwiritsidwe ntchito mwa ana azaka 10 ndi akulu (monotherapy, osakanikirana ndi insulin).

Analogue ndiyotsika mtengo kuchokera ku 1470 rubles.

Metformin ndiyotheka kulowa m'malo mwa mapiritsi a Trazent. Mankhwalawa amasiyana malinga ndi zomwe zimagwiritsidwa ntchito komanso kuchuluka kwa mankhwalawa, koma Metformin amathanso kuuzidwa ndi dokotala kuti athandizire matenda a shuga a mtundu wachiwiri. Mankhwalawa amathandizidwa pakudya, kapena akangomaliza kudya, mlingo wa tsiku ndi tsiku umakhazikitsidwa ndi adokotala.

Analogue ndiotsika mtengo kuchokera ku ma ruble 857.

Galvus ndi mankhwala ochokera ku Switzerland ozikidwa pa vildagliptin mu mlingo wa 50 mg. Ngakhale pali kusiyana pakumwa ndi mankhwala a Trazhenta, Galvus amathanso kuikidwa ngati katswiri pochiza matenda amisala 2 a shuga (monga gawo la mono- kapena mankhwala ophatikiza). Pali zosiyana ndi "choyambirira" pa contraindication ndi mlingo. Musanayambe chithandizo, onetsetsani kuti mukumane ndi katswiri.

Vipidia (mapiritsi) → Chingwe cholowa m'malo: 8 Up

Analogue ndiotsika mtengo kuchokera ku ma ruble 675.

Vipidia amatanthauza mankhwala a hypoglycemic ogwiritsira ntchito mkati ndipo ali ndi 12.5 mg alogliptin piritsi. Itha kugwiritsidwanso ntchito mtundu wa 2 shuga mellitus wokhala ndi chakudya chokwanira komanso / kapena zochitika zolimbitsa thupi.

Analogue ndiokwera mtengo kwambiri kuchokera ku ma ruble 124.

Onglisa ndi mankhwala okwera mtengo kwambiri opangidwa ndi America. Imapezekanso mu mawonekedwe a piritsi, koma ilinso ndi chinthu china (saxagliptin) mu gawo la 2.5 kapena 5 mg piritsi limodzi. Malinga ndi zomwe zikuwonetsa kuti pakhale kusiyana kwakukulu ndi mankhwala "oyambayo" kulibe.

Analogue ndiokwera mtengo kwambiri kuchokera ku ma ruble 561.

Januvia imapezeka m'mapiritsi 28, koma imawononga ndalama zambiri kuposa Trazhenta. Chifukwa cha kusiyana kwazomwe zimapangidwira, zitha kutumikiridwa ngati choloweza mmalo, chifukwa m'malo mwa linagliptin, Januvia imakhala ndi sitagliptin mu gawo loyenera kuchokera ku 25 mpaka 100 mg. Ndi mankhwalawa pochiza matenda amishuga amtundu wa 2 (mtundu wa mono-ndi mankhwala osakanikirana).

Milandu yama bongo osokoneza bongo

Zambiri zakufufuza zamankhwala zikuwonetsa kuti kugwiritsa ntchito kamodzi kwa 600 mg ya mankhwalawa sikuyambitsa zizindikiro zowonjezera ndipo sikuvulaza thanzi la odwala matenda ashuga. Palibe chidziwitso cha milandu ya bongo. Komabe, pofuna kuteteza, mukamagwiritsa ntchito mankhwala ochulukirapo, ndikofunikira kuchotsa m'mimba pang'onopang'ono kapena kusanza.

Onetsetsani kuti mukumane ndi dokotala kapena kuyimbira gulu la ambulansi. Mwina pali kuphwanya kulikonse kwaumoyo, ndikofunikira kupereka mankhwala okwanira.

China chake ndikusintha koyipa kwa thupi, kuchuluka kwa izi zimachitika ndikofanana ndi kuchuluka kwa zotsatira zoyipa chifukwa chotenga placebo. Chifukwa chake, wodwalayo angayambe: njira yotupa mu kapamba, kutsokomola, nasopharyngitis, chidwi cha zinthu zina, hypertriglyceridemia.

Muyenera kudziwa kuti yogwira mankhwala ingayambitse chizungulire, chifukwa chake:

• ndibwino kukana kuyendetsa galimoto ndi machitidwe ena ovuta,
• Pewani kuchita masewera olimbitsa thupi mopitirira malire.

Zotsatira zoyipa zomwe zimatchulidwa zimachitika nthawi ya mankhwala a Trazent limodzi ndi zotumphukira za sulfonylurea ndi Metformin.

Mankhwalawa akaphatikizidwa ndi mankhwala a linagliptin kapena pioglitazone, odwala matenda ashuga nthawi zambiri amawonjezera kulemera, kapamba, hypersensitivity ya chitetezo chathupi.

Malangizo apadera

Mankhwalawa sanatchulidwe kwa amayi apakati, momwe zimayambira m'thupi la munthu wamkazi pakadabereka mwana sizinaphunzire mpaka pano. Komabe, mayesero azachipatala mwa nyama sanawonetse vuto lililonse pakubereka. Kuyesa pa kuthekera kwa kubereka kwa amayi sikunachitike, kuyesa kwa nyama sikunawonetse zotsatira zoyipa.

Zambiri zomwe zimapezeka pazolemba zamankhwala a pharmacodynamic zimawonetsa kulowetsedwa kwa mankhwalawa mkaka wa m'mawere. Pazifukwa izi, momwe mankhwalawo amathandizira mwana sikuchotsedwa. Nthawi zina, madokotala amaumiriza kukomoka kwa mkaka mwa mayi, ngati pakufunika kuti amuwonetsere Trazhenta weniweni.

Malangizo a Trazenta ogwiritsira ntchito akuwonetsa kuti ndikofunikira kusunga mankhwalawo pa kutentha kosaposa 25 digiri pamalo amdima, kutali ndi ana. Moyo wa alumali ndi zaka 2,5.

Endocrinologists samapereka mankhwala kwa odwala:

1. ndi matenda a shuga 1
2. ndi matenda ashuga ketoacidosis.

Anthu omwe ali ndi matenda ashuga amatha kukhala ndi hypoglycemia, chifukwa chake chimatha kuphatikizidwa ndi chithandizo cha molumikizana ndi sulfonylureas.

Palibe deta pakukhudzana ndi mankhwalawa ndi insulin; odwala omwe amalephera kupweteka aimpso amathandizidwa kulandira chithandizo pamodzi ndi mankhwala ena kuti achulukitse matenda a glycemia. Ndemanga za Trazenta nthawi zonse zimakhala zabwino.

Mukagwiritsidwa ntchito molumikizana ndi mankhwalawa, Ritonavir imakulitsa linagliptin pafupifupi katatu, kutsanulira kosasunthika (nthawi zambiri 1% ya mankhwala othandizira) kudzawonjezeka kasanu pambuyo pa kuphatikiza mankhwalawa. Kusintha kotereku mu pharmacokinetics sikuti kumawoneka kuti ndi kwamankhwala kwakukulu, chifukwa cha ichi, kulumikizana kwakukulu ndi zoletsa zina sikukuyembekezeka, mulingo woyeserera sawunikiranso.

Pochiza ndi Rifampicin, pali kuchepa kwama pharmacokinetics a mankhwalawa onse kuchokera pa 39 mpaka 43%, kutsika kwa ntchito zapansi zapansi ndi 30%. Mphamvu ya chithandizo imasungidwa, koma sizichitika mokwanira.

Pogwiritsa ntchito Trazhenty ndi Digoxin, zotsatira zoyanjana sizimachitika, ngakhale kuphatikiza kumene kumagwiritsidwa ntchito:

• mobwerezabwereza
• Mlingo wosiyanasiyana.

Mobwerezabwereza kugwiritsa ntchito mankhwalawa mlingo wa 5 mg / tsiku sangathe kusintha pharmacokinetics ya Warfarin. Ngati Simvastatin ndi kuchuluka kwa linagliptin kumagwiritsidwa ntchito mobwerezabwereza, pharmacokinetics ya mankhwala oyamba amakhudzidwa. Izi ndizabwinobwino; kusintha masinthidwe ofunikira sikofunikira. Pambuyo mankhwala okhazikika ndi Trazenta kuchuluka ndipo Simvastatin 40 mg, ntchito yotsiriza inakula ndi 34%, m'magazi ndi 10%.

Munthu wodwala matenda ashuga amtundu wachiwiri atenga njira zakulera pakamwa motsutsana ndi maziko a chithandizo cha Trezhenta, palibe kusintha kosasunthika komanso kwakukulu mu pharmacokinetics yamankhwala otere.

Ndemanga zowoneka

Ma Dhib-4 inhibitors (mankhwalawa ndi a gululi) amadziwika osati ndi chiwonetsero chochepa chotsitsa shuga, komanso ndi chiwopsezo chowonjezeka, popeza sangathe kuyambitsa kuchuluka kwa thupi la odwala matenda ashuga komanso a hypoglycemic. Mankhwala a gululi amawonedwa kuti ndi othandiza komanso odalirika kwambiri pa chithandizo cha matenda amtundu wa 2 ana ndi akulu.

Kuchita bwino kwa mankhwala kwatsimikiziridwa ndi maphunziro ambiri asayansi, ndikofunikira kuyambitsa maphunziro othandizira kuphatikiza ndi mankhwala ena. Pamaso patsogola kusiyana kwa glucose ndende ndikuchepa kwake, m'malo mwa sulfonylureas akuwonetsedwa.

Nthawi zina zimakhala zomveka kugwiritsa ntchito mankhwalawa ngati njira yoperekera monotherapy ndi kukana kwa thupi ku insulin yamafuta komanso kunenepa kwambiri. Patatha miyezi itatu yakuthandizira, kuchepa kwakukulu kwa zolemetsa kumadziwika.

Chiwerengero chachikulu cha ndemanga chinalandiridwa kuchokera kwa odwala matenda ashuga omwe amagwiritsa ntchito 5 mg ya mankhwalawa ngati gawo la zovuta mankhwala. Poona izi, ndikovuta kuti kumuwunika moyenera Trazhent ndi iye:

Komabe, pafupifupi odwala onse akutsimikiza kuti ndi mankhwalawa omwe adawathandiza kuti achepetse thupi.

Ngakhale zoletsa zina pa ntchito ya Trazent, zimalembedwa kwa odwala matenda ashuga a mtundu wachiwiri uliwonse, kuphatikiza okalamba, omwe akuvutika ndi matenda a impso, chiwindi, mtima. Zotsatira zoyipa kwambiri za mankhwalawa ndi nasopharyngitis.

Zambiri pazomwe DPP-4 inhibitors yaperekedwa kanema munkhaniyi.