NEURORUBINE FORTE LACTAB N20

• Zizindikiro zogwiritsidwa ntchito
• Njira yogwiritsira ntchito
• Zotsatira zoyipa
• Kuchita ndi mankhwala ena
• Contraindication
• Mimba
• Bongo
• Malo osungira
• Kutulutsa Fomu
• Kupanga
• Zosankha

Neurorubin-Forte Lactab - Kukonzekera kwa kuphatikiza komwe kumakhala ndi mavitamini a neurotropic a gulu B. Magawo omwe amagwira mankhwalawa - mavitamini B1, B6, B12 akukhudzidwa ndi zochitika zamtunduwu zomwe zimatsimikizira kufalitsa kwa kutulutsa motsatana ndi minyewa ya mitsempha, kagayidwe kachakudya, komanso kagayidwe ka oyimira pakati mu dongosolo lamanjenje.
Thiamine (Vitamini B1), yotukuka mkati mwa ziwalo zamitsempha, imakhudzidwa ndikupanga kukhudzidwa kwa mitsempha, imathandizanso kukonzanso minofu ya mitsempha. Mukakulitsa kuchuluka kwa thiamine m'magazi, kumalimbikitsa kukula kwa analgesic kwenikweni.
Pyridoxine (Vitamini B6) amakhudza kapangidwe kake ka minyewa yamanjenje, choyamba ndikukhazikitsa kagayidwe ka amino acid, kamene kamalepheretsa kuchuluka kwa poizoni wa neurotropic - ammonia. Amatenga nawo kapangidwe ka oyimira pakati osiyanasiyana: makatekolamaini, histamine, GABA, amawonjezera masitolo owonjezera a magnesium, omwe amagwira ntchito yofunika kwambiri mu metabolic, mwachitsanzo, kayendetsedwe ka mphamvu ndi ntchito yamanjenje.
Cyanocobalamin (Vitamini B12) imayambitsa metabolic kagayidwe ndipo amatenga nawo mbali, motero, pokhalitsa hematopoiesis, komanso amachepetsa neurogenic nocicept.
Pharmacokinetics
Thiamine mononitrate (Vitamini B1) pambuyo pakamwa amachepetsa mu duodenum ndi matumbo ochepa. Kukula kwakukulu, imapangidwa m'chiwindi ndipo metabolites yake yayikulu ndi thiamincarboxylic acid ndi piramidi (2,5-dimethyl-4-aminopyridimine). Ma metabolabolites pamodzi ndi thiamine osasinthika amathandizidwa kudzera m'matumbo ndi impso.
Pyridoxine hydrochloride (Vitamini B6) amatengedwa mwachangu kuchokera m'matumbo. Zimapangidwa m'chiwindi ndikupanga mapiritsi a pacidoxalphosphate ndi pyridoxamine phosphate. Vitamini B6 imagwira ntchito ngati coenzyme itatha phosphorylation ya gulu la CH2OH pamalo a 5, mwa kuyankhula kwina kupanga kwa pyridoxal 5-phosphate (PALP). Pafupifupi 80% ya PALP imamangilira mapuloteni a plasma. Pyridoxine imadziunjikira kumlingo waukulu, chiwindi ndi dongosolo lamanjenje lamkati. Kukonzekera komaliza kwa pyridoxine metabolism ndi 4-pyridoxyl acid, yomwe impso imakumba.
Cyanocobalamin (Vitamini B12). Kuchuluka kwa cyanocobalamin kumayamwa pambuyo kumangiriza ku Castle mkati. Vitamini B12 imadziunjikira kumlingo waukulu. T1 / 2 kuchokera ku seramu ili pafupi masiku 5, kuchokera ku chiwindi - pafupifupi chaka chimodzi. Amapukusidwa makamaka ndi bile ndi mkodzo.

Zizindikiro zogwiritsidwa ntchito

Neurorubin-Forte Lactab Ndikulimbikitsidwa kutenga monga gawo la chithandizo chokwanira:
- neuralgia, neuritis, polyneuritis,
- neuropathy, polyneuropathy (kuphatikizapo matenda ashuga, mowa),
- Mawonetseredwe amtundu wa osteochondrosis a msana (sciatica, radiculopathy, minofu-tonic syndromes).

Njira yogwiritsira ntchito

Neurorubin-Forte Lactab yoika mkati, musanadye kapena chakudya. Mapiritsiwo amametsedwa osafuna kutafuna, osambitsidwa ndi madzi okwanira.
Akuluakulu amalangizidwa kumwa mapiritsi a 1-2 /
Njira ya mankhwala ndi milungu 4. Kuthekera kochita mobwerezabwereza maphunziro kumathandizidwa ndi adokotala omwe amapita kuchipatala.

Zotsatira zoyipa

Zotsatira zamagetsi: nthawi zina - kuyabwa, ming'oma, kupuma movutikira, edema ya Quincke, kuwopsa kwa anaphylactic.
Kuchokera pamatumbo am'mimba: nthawi zina - nseru, kutaya magazi m'mimba, ntchito yowonjezera ya AST.
Kuchokera pamtima: mu tachycardia, kugwa, cyanosis, pulmonary edema.
Otsala: nthawi zina - thukuta losayembekezereka, kumverera kosathandiza, chizungulire, nkhawa, ziphuphu zakumaso, kuletsa kwa secretion ya prolactin.

Kuchita ndi mankhwala ena

Popeza pyridoxine hydrochloride imakwiyitsa decarboxylation wa L-dopamine (levodopa) ndipo ingachepetse kuchiritsa kwa mankhwalawa pochiza odwala omwe ali ndi matenda a Parkinson, kugwiritsa ntchito mankhwalawa sikuyenera kuphatikizidwa.
Thiosemicarbazone ndi 5-fluorouracil amachepetsa mphamvu ya vitamini B1, pokhala omutsutsa.
Maantacidin amachepetsa kuyamwa kwa vitamini B1.

Kutulutsa Fomu

Neurorubin-Forte Lactab - Mapiritsi.
Kuyika - mapiritsi 20.

Neurorubin-Forte Lactab Muli yogwira: thiamine mononitrate (vit. B1) 200 mg, pyridoxine hydrochloride (vit. B6) 50 mg, cyanocobalamin (vit. B12) 1 mg.
Omwe amathandizira: hypromellose, mannitol, cellulose yafumbi, cellcrystalline cellulose, pregelatinized starch, magnesium stearate, colloidal silicon dioxide.
Zomwe zimapangidwa ndi membrane wa filimuyi: hypromellose, macrogol 6000, talc, titanium dioxide (E171), erythrosine (E127).

NEURORUBINE FORTE TABLETES N20

NEURORUBINE FORTE TABLETES N20

Dzinalo: Neurorubine

Machitidwe
Kupanga mavitamini kovuta komwe kumakhala ndi mavitamini osungunuka a B. Mavitamini a B ali ndi zochitika zambiri zokhudzana ndi chilengedwe, ngakhale zili zofanana ndi zamankhwala, mavitamini aliwonse amathandizira thupi. Makamaka:
Vitamini B1 amatenga nawo gawo mu chakudya cha carbohydrate, ndi kuchepa kwake kuchuluka kwa lactic ndi pyruvic acid m'thupi kumadziwika. Amathandizira pakupanga ndi kusinthana kwa amino acid, motero kuyang'anira kagayidwe kazakudya zomanga thupi. Mu metabolism yamafuta, vitamini B1 amawongolera mapangidwe a mafuta acids ndipo amathandizira kusintha kwa mafuta kukhala mafuta. Mitundu yogwira ya Vitaminiyi imapangitsa kuti matumbo asamayende bwino komanso kuti chitseko chizigwira ntchito. Vitamini B1 imayendetsa njira za ion mu cell membrane ya ma neurons, motero zimakhudza kuperekedwa kwa zophatikizika muzinthu zamitsempha.

Vitamini B6 imakhudzidwa ndi kapangidwe ka michere, mapuloteni komanso metabolism yamafuta. Wogwira mawonekedwe a Vitaminiyi amakhudzidwa ndi mitundu yosiyanasiyana ya michere ngati coenzyme. Pyridoxine amawongolera kaphatikizidwe ka ma neurotransmitters mu ma synapses apakati ndi zotumphukira, amatenga nawo mbali pakapangidwe ka myelin membrane wa neurons. Zimasintha kupanga mphamvu, zimagwira nawo lipid ndi protein metabolism, ndikuwongolera kaphatikizidwe ka hemoglobin.

Vitamini B12 imagwira ntchito yofunika kwambiri mumapuloteni, imayendetsa kapangidwe ka amino acid, purines ndi ma nucleic acid. Cyanocobalamin ndiyofunikira kuti yachibadwa njira ya kamangidwe ka minyewa ndi mapangidwe acetylcholine. Mlingo waukulu wa cyanocobalamin umathandizira kukulitsa bwino kwa kutsekeka kwa mitsempha pamodzi ndi zopangika za mitsempha ndikulimbikitsanso kukonzanso kwa minyewa yamitsempha. Chimodzi mwazinthu zazikulu za vitamini B12 ndi mphamvu yake ya antianemic. Cyanocobalamin ali ndi hematopoietic kwenikweni, imapangitsa erythropoiesis. Vitamini B12 imasintha bwino hepatic hematopoiesis, imachepetsa mphamvu ya magazi, komanso imathandiza kuchepetsa magazi m'thupi.

Mankhwala Neurorubin ali ndi mitundu yayikulu yothandizira ya mavitamini omwe ali pamwambawa, omwe pamodzi amathandizira kuti magwiridwe amachitidwe amanjenje amathandizira lipid, chakudya komanso mapuloteni a protein. Kuphatikiza apo, kuphatikiza kwa mavitamini a B kumathandizira kuchepetsa ululu ndi neuralgia yamayendedwe osiyanasiyana.

The pharmacokinetics ya mankhwala Neurorubin ndi chifukwa cha pharmacokinetic katundu wake zigawo zikuluzikulu:
Thiamine mononitrate pambuyo pakamwa, kuyamwa kwa thiamine kumachitika makamaka m'matumbo aang'ono, duodenum ndi jejunum. Mankhwala ochepa omwe amamwa m'chiwindi, mankhwalawa amaphatikizidwa m'thupi ndikupanga thiaminocarboxylic acid ndi piramidi. Mphindi 30 pambuyo pakumwa pakamwa, kuchuluka kwa mankhwalawo m'magazi ndikotsika kwambiri kuposa ziwalo ndi zimakhala. Amachotsa m'thupi ndi impso komanso matumbo, osasinthika komanso mawonekedwe a metabolites.
Pyridoxine hydrochloride imayamwa bwino m'matumbo, imapangidwa mu thupi ndikupanga metabolites yogwira ya pyridoxal ndi pyridoxamine. Kuphatikiza apo, pyridoxal-5-phosphate ndi mtundu wogwira mankhwala, womwe umagwira ntchito ya coenzyme m'thupi. Pyridoxine amadziwika ndi gawo lalikulu lomangiriza mapuloteni a plasma (mpaka 80%). Kukopa kwa mankhwalawa mu chiwindi, minofu ndi dongosolo lamkati la mantha kunadziwika. Amachotsa m'thupi ndi impso mu mawonekedwe a metabolites yogwira komanso yolimba.

Kwa mayamwidwe abwinobwino a cyanocobalamin m'matumbo awo, kukhalapo kwa Castle factor ndikofunikira, komwe kumatsimikizira kuyamwa kwa mankhwalawa mu kayendetsedwe kazinthu. Kagayidwe ka cyanocobalamin, chifukwa chomwe yogwira metabolite adenosylcobalamin imapangika, imapezeka mu minofu. Amachotseredwa mkodzo ndi bile. Amadziunjikira m'chiwindi. Hafu ya moyo wa mankhwala am'magazi ndi masiku 5, kuchokera ku chiwindi minofu - pafupifupi chaka chimodzi.

Zisonyezo zogwiritsidwa ntchito:
Mankhwala amagwiritsidwa ntchito mu zinthu zomwe zimayendera limodzi ndi zizindikiro za hypovitaminosis ya mavitamini a gulu B m'thupi.
Mapiritsi okhala ndi filimu, Neurorubin-Forte Lactab amagwiritsidwa ntchito popanga zovuta ngati matenda:
Ululu m'mitundu yamatenda am'mimba komanso polyneuritis,
Neuralgia, ndi kuwonongeka kwamitsempha yamagetsi panthawi ya kuledzera ndi zinthu zosiyanasiyana, kuphatikizapo kuledzera ndi poyizoni wa mankhwala,
Matenda a shuga a polyneuropathy.
Njira yothandizira jakisoni Neurorubin amagwiritsidwa ntchito ngati monotherapy kapena kuphatikiza ndi mankhwala ena a matenda awa:
Neuropathies, kuphatikizapo zotumphukira, zimayambitsidwa ndi mowa.
Anthu odwala matenda ashuga polyneuropathies.
Vitamini B hypovitaminosis, youma ndi chonyowa beriberi.
Neuralgia, kuphatikizapo cervicobrachial ndi trigeminal neuralgia.
Pachimake ndi matenda a minyewa yamatumbo ndi polyneuritis osiyanasiyana etiologies.

Njira yogwiritsira ntchito:
Mlingo wa mankhwala ndi kutalika kwa nthawi ya chithandizo akutsimikiza ndi kupezeka kwa dokotala aliyense payekha kwa wodwala aliyense.
Mapiritsi okhala ndi filimu, Neurorubin-Forte Lactab amatengedwa pakamwa ndi madzi okwanira, makamaka musanadye kapena panthawi ya chakudya, osavomerezeka kugawa kapena kutafuna mapiritsi okhala ndi filimu. Akuluakulu nthawi zambiri amapatsidwa mapiritsi 1-2 patsiku. Kutalika kwa mankhwala nthawi zambiri mwezi umodzi.

Jakisoni wothandizirana Neurorubin amagwiritsidwa ntchito jakisoni wa mu mnofu; jekeseni amalimbikitsidwa pamalo apamwamba a minofu ya gluteal.
Mlingo wa mankhwala ndi pafupipafupi jakisoni zimatengera kuopsa kwa hypovitaminosis.
Woopsa, 3 ml ya mankhwalawa nthawi zambiri amaperekedwa tsiku lililonse kapena kamodzi m'masiku awiri mpaka mphamvu ya ululu itachepa, pambuyo pake amasinthana ndi 3 ml ya mankhwala 1-2 pakadutsa masiku 7.
M'magawo olimbitsa, 3 ml ya mankhwalawa nthawi zambiri amaperekedwa nthawi 1-2 m'masiku 7.
Kutalika kwa mankhwala aubwino ndi Neurorubin zimatengera chifukwa cha hypovitaminosis. Mukamapatsa mankhwala osokoneza bongo kwa nthawi yayitali, magawo a ma labotale amayenera kuwunikira miyezi isanu ndi umodzi iliyonse.

Zotsatira zoyipa:
Mukamagwiritsa ntchito mankhwalawa odwala, zotsatirazi zoyipa zimadziwika:
Kuchokera pamiyambo ya kugaya chakudya: nseru, kusanza, kuchuluka kwa hepatic transaminases m'magazi. Odwala omwe ali ndi vuto laumwini, kutuluka kwa m'mimba kunadziwika pamene amamwa mankhwalawo.
Kuchokera pakatikati ndi potumphukira mantha dongosolo: kufooka, mutu, chizungulire. Pazinthu zina, nkhawa, kuchuluka kwa mkwiyo ndi nkhawa zimadziwika. Pogwiritsa ntchito mankhwalawa muyezo waukulu, odwala ena adanenanso za kupezeka kwa zotumphukira zamitsempha, zomwe zimachitika atasiya kumwa mankhwalawa.

Kuchokera pamtima dongosolo: tachycardia, kuzungulira kwa magazi (kumawonekera kokha mwa odwala omwe ali ndi chidwi chamunthu).
Thupi lawo siligwirizana: kuyabwa pakhungu, zidzolo, urticaria, pamene kumwa Mlingo waukulu wa mankhwala odwala, kukula kwa ziphuphu kumadziwika.
Zotsatira zina zoyipa: cyanosis, edema ya m'mapapo, thukuta. Odwala omwe ali ndi vuto la hypersensitivity ku zigawo zikuluzikulu za mankhwalawo, zimachitika kuti anaphylactoid, kuphatikizapo edincke edema. Ndi kholo makonzedwe a mankhwala kwa odwala omwe ali ndi hypersensitivity mpaka B mavitamini, anaphylactic mantha angayambe.

Zoyipa:
Kuchulukitsa kumvetsetsa kwamunthu pazigawo za mankhwala.
Amalembedwa mosamala kwa odwala omwe ali ndi psoriasis, chifukwa cyanocobalamin ikhoza kuyipa mu psoriasis.
Mankhwala Neurorubin mu mawonekedwe a yankho la jakisoni sagwiritsidwa ntchito pa nthawi yoyembekezera komanso mkaka wa m`mawere, komanso kwa ana osakwana zaka 16.

Mimba
Mankhwala amawoloka chotupa cha hematoplacental ndipo amatsimikiza mkaka wa m'mawere. Palibe chidziwitso chokhudza chitetezo cha mankhwalawa panthawi yapakati komanso mkaka wa m`mawere. Mankhwala omwe ali ndi pakati amatha kuthandizidwa ndi adotolo ngati phindu lomwe mayi akuyembekeza limayesa chiwopsezo cha mwana wosabadwayo. Ngati ndi kotheka kuti mupeze mankhwalawa panthawi yoyamwitsa, ndikofunikira kusankha pakuletsa kuyamwitsa.

Mogwirizana ndi mankhwala ena:
Pogwiritsa ntchito munthawi yomweyo, mankhwalawa amachepetsa achire zotsatira za levodopa, zomwe ziyenera kuganiziridwa pochiza odwala omwe ali ndi matenda a Parkinson komanso kupewa kugwiritsa ntchito mankhwalawa munthawi yomweyo.
Pogwiritsa ntchito munthawi yomweyo, mankhwala a Neurorubin amathandizira poizoni wa isoniazid.
Neurorubin chifukwa cha Vitamini B6 imatha kuchepetsa kugwiritsidwa ntchito kwa altretamine pogwiritsa ntchito munthawi yomweyo.
Thiosemicarbazone ndi fluorouracil ndi otsutsana ndi vitamini B1.
Mankhwala okhala ndi envelopu ndi ma antacid amachepetsa kuyamwa kwa mankhwala Neurorubin-Forte Lactab.

Bongo
Ndi mankhwala osokoneza bongo odwala, kuwonjezereka kwa zovuta zoyipa kumadziwika.
Palibe mankhwala enieni. Pankhani ya bongo, chapamimba thonje ndi makonzedwe a enterosorbents akuwonetsedwa. Mankhwalawa ndi chizindikiro. Ndi kupanga anaphylactic mantha, glucocorticosteroids ogwiritsa ntchito mwadongosolo komanso antihistamines amagwiritsidwa ntchito.

Kutulutsa Fomu:
Mapiritsi, okutira-kanema, zidutswa 10 mu chithuza, matuza awiri mu bokosi lamatoni.
3 ml jakisoni yankho mu ampoule, ma ampoules asanu mu katoni.

Malo osungirako:
Mankhwala tikulimbikitsidwa kuti tisungidwe m'malo owuma kutali ndi dzuwa. Mapiritsi a Neurorubin-Forte Lactab akulimbikitsidwa kuti asungidwe pamtunda wa 15 mpaka 25 digiri Celsius.
Njira yothetsera jakisoni Neurorubin tikulimbikitsidwa kuti isungidwe pamtunda wa 2 mpaka 8 digiri Celsius.
Alumali moyo wa mankhwala mu mawonekedwe a yankho la jakisoni ndi zaka zitatu.
Alumali moyo wa mankhwala osokoneza mapiritsi ndi zaka 4.

Mawu:
Neurovitan, Milgamm.

Zopangidwa:
3 ml (1 ampoule) wa jakisoni muli:
Thiamine hydrochloride - 100 mg,
Pyridoxine hydrochloride - 100 mg,
Cyanocobalamin - 1 mg.
Othandizira.

Piritsi limodzi lachifundo 1
Thiamine mononitrate - 200 mg,
Pyridoxine hydrochloride - 50 mg,
Cyanocobalamin - 1 mg.
Othandizira.

Yang'anani!
Musanagwiritse ntchito mankhwala Neurorubin muyenera kufunsa dokotala. Bukuli limaperekedwa mwa kutanthauzira kwaulere ndipo cholinga chake ndi chidziwitso chabe. Kuti mumve zambiri, chonde onani zomwe akupanga.
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Dzinalo: Neurorubine

Machitidwe
Kupanga mavitamini kovuta komwe kumakhala ndi mavitamini osungunuka a B. Mavitamini a B ali ndi zochitika zambiri zokhudzana ndi chilengedwe, ngakhale zili zofanana ndi zamankhwala, mavitamini aliwonse amathandizira thupi. Makamaka:
Vitamini B1 amatenga nawo gawo mu chakudya cha carbohydrate, ndi kuchepa kwake kuchuluka kwa lactic ndi pyruvic acid m'thupi kumadziwika. Amathandizira pakupanga ndi kusinthana kwa amino acid, motero kuyang'anira kagayidwe kazakudya zomanga thupi. Mu metabolism yamafuta, vitamini B1 amawongolera mapangidwe a mafuta acids ndipo amathandizira kusintha kwa mafuta kukhala mafuta. Mitundu yogwira ya Vitaminiyi imapangitsa kuti matumbo asamayende bwino komanso kuti chitseko chizigwira ntchito. Vitamini B1 imayendetsa njira za ion mu cell membrane ya ma neurons, motero zimakhudza kuperekedwa kwa zophatikizika muzinthu zamitsempha.

Vitamini B6 imakhudzidwa ndi kapangidwe ka michere, mapuloteni komanso metabolism yamafuta. Wogwira mawonekedwe a Vitaminiyi amakhudzidwa ndi mitundu yosiyanasiyana ya michere ngati coenzyme. Pyridoxine amawongolera kaphatikizidwe ka ma neurotransmitters mu ma synapses apakati ndi zotumphukira, amatenga nawo mbali pakapangidwe ka myelin membrane wa neurons. Zimasintha kupanga mphamvu, zimagwira nawo lipid ndi protein metabolism, ndikuwongolera kaphatikizidwe ka hemoglobin.

Vitamini B12 imagwira ntchito yofunika kwambiri mumapuloteni, imayendetsa kapangidwe ka amino acid, purines ndi ma nucleic acid. Cyanocobalamin ndiyofunikira kuti yachibadwa njira ya kamangidwe ka minyewa ndi mapangidwe acetylcholine. Mlingo waukulu wa cyanocobalamin umathandizira kukulitsa bwino kwa kutsekeka kwa mitsempha pamodzi ndi zopangika za mitsempha ndikulimbikitsanso kukonzanso kwa minyewa yamitsempha. Chimodzi mwazinthu zazikulu za vitamini B12 ndi mphamvu yake ya antianemic. Cyanocobalamin ali ndi hematopoietic kwenikweni, imapangitsa erythropoiesis. Vitamini B12 imasintha bwino hepatic hematopoiesis, imachepetsa mphamvu ya magazi, komanso imathandiza kuchepetsa magazi m'thupi.

Mankhwala Neurorubin ali ndi mitundu yayikulu yothandizira ya mavitamini omwe ali pamwambawa, omwe pamodzi amathandizira kuti magwiridwe amachitidwe amanjenje amathandizira lipid, chakudya komanso mapuloteni a protein. Kuphatikiza apo, kuphatikiza kwa mavitamini a B kumathandizira kuchepetsa ululu ndi neuralgia yamayendedwe osiyanasiyana.

The pharmacokinetics ya mankhwala Neurorubin ndi chifukwa cha pharmacokinetic katundu wake zigawo zikuluzikulu:
Thiamine mononitrate pambuyo pakamwa, kuyamwa kwa thiamine kumachitika makamaka m'matumbo aang'ono, duodenum ndi jejunum. Mankhwala ochepa omwe amamwa m'chiwindi, mankhwalawa amaphatikizidwa m'thupi ndikupanga thiaminocarboxylic acid ndi piramidi. Mphindi 30 pambuyo pakumwa pakamwa, kuchuluka kwa mankhwalawo m'magazi ndikotsika kwambiri kuposa ziwalo ndi zimakhala. Amachotsa m'thupi ndi impso komanso matumbo, osasinthika komanso mawonekedwe a metabolites.
Pyridoxine hydrochloride imayamwa bwino m'matumbo, imapangidwa mu thupi ndikupanga metabolites yogwira ya pyridoxal ndi pyridoxamine. Kuphatikiza apo, pyridoxal-5-phosphate ndi mtundu wogwira mankhwala, womwe umagwira ntchito ya coenzyme m'thupi. Pyridoxine amadziwika ndi gawo lalikulu lomangiriza mapuloteni a plasma (mpaka 80%). Kukopa kwa mankhwalawa mu chiwindi, minofu ndi dongosolo lamkati la mantha kunadziwika. Amachotsa m'thupi ndi impso mu mawonekedwe a metabolites yogwira komanso yolimba.

Kwa mayamwidwe abwinobwino a cyanocobalamin m'matumbo awo, kukhalapo kwa Castle factor ndikofunikira, komwe kumatsimikizira kuyamwa kwa mankhwalawa mu kayendetsedwe kazinthu. Kagayidwe ka cyanocobalamin, chifukwa chomwe yogwira metabolite adenosylcobalamin imapangika, imapezeka mu minofu. Amachotseredwa mkodzo ndi bile. Amadziunjikira m'chiwindi. Hafu ya moyo wa mankhwala am'magazi ndi masiku 5, kuchokera ku chiwindi minofu - pafupifupi chaka chimodzi.

Zisonyezo zogwiritsidwa ntchito:
Mankhwala amagwiritsidwa ntchito mu zinthu zomwe zimayendera limodzi ndi zizindikiro za hypovitaminosis ya mavitamini a gulu B m'thupi.
Mapiritsi okhala ndi filimu, Neurorubin-Forte Lactab amagwiritsidwa ntchito popanga zovuta ngati matenda:
Ululu m'mitundu yamatenda am'mimba komanso polyneuritis,
Neuralgia, ndi kuwonongeka kwamitsempha yamagetsi panthawi ya kuledzera ndi zinthu zosiyanasiyana, kuphatikizapo kuledzera ndi poyizoni wa mankhwala,
Matenda a shuga a polyneuropathy.
Njira yothandizira jakisoni Neurorubin amagwiritsidwa ntchito ngati monotherapy kapena kuphatikiza ndi mankhwala ena a matenda awa:
Neuropathies, kuphatikizapo zotumphukira, zimayambitsidwa ndi mowa.
Anthu odwala matenda ashuga polyneuropathies.
Vitamini B hypovitaminosis, youma ndi chonyowa beriberi.
Neuralgia, kuphatikizapo cervicobrachial ndi trigeminal neuralgia.
Pachimake ndi matenda a minyewa yamatumbo ndi polyneuritis osiyanasiyana etiologies.

Njira yogwiritsira ntchito:
Mlingo wa mankhwala ndi kutalika kwa nthawi ya chithandizo akutsimikiza ndi kupezeka kwa dokotala aliyense payekha kwa wodwala aliyense.
Mapiritsi okhala ndi filimu, Neurorubin-Forte Lactab amatengedwa pakamwa ndi madzi okwanira, makamaka musanadye kapena panthawi ya chakudya, osavomerezeka kugawa kapena kutafuna mapiritsi okhala ndi filimu. Akuluakulu nthawi zambiri amapatsidwa mapiritsi 1-2 patsiku. Kutalika kwa mankhwala nthawi zambiri mwezi umodzi.

Jakisoni wothandizirana Neurorubin amagwiritsidwa ntchito jakisoni wa mu mnofu; jekeseni amalimbikitsidwa pamalo apamwamba a minofu ya gluteal.
Mlingo wa mankhwala ndi pafupipafupi jakisoni zimatengera kuopsa kwa hypovitaminosis.
Woopsa, 3 ml ya mankhwalawa nthawi zambiri amaperekedwa tsiku lililonse kapena kamodzi m'masiku awiri mpaka mphamvu ya ululu itachepa, pambuyo pake amasinthana ndi 3 ml ya mankhwala 1-2 pakadutsa masiku 7.
M'magawo olimbitsa, 3 ml ya mankhwalawa nthawi zambiri amaperekedwa nthawi 1-2 m'masiku 7.
Kutalika kwa mankhwala aubwino ndi Neurorubin zimatengera chifukwa cha hypovitaminosis. Mukamapatsa mankhwala osokoneza bongo kwa nthawi yayitali, magawo a ma labotale amayenera kuwunikira miyezi isanu ndi umodzi iliyonse.

Zotsatira zoyipa:
Mukamagwiritsa ntchito mankhwalawa odwala, zotsatirazi zoyipa zimadziwika:
Kuchokera pamiyambo ya kugaya chakudya: nseru, kusanza, kuchuluka kwa hepatic transaminases m'magazi. Odwala omwe ali ndi vuto laumwini, kutuluka kwa m'mimba kunadziwika pamene amamwa mankhwalawo.
Kuchokera pakatikati ndi potumphukira mantha dongosolo: kufooka, mutu, chizungulire. Pazinthu zina, nkhawa, kuchuluka kwa mkwiyo ndi nkhawa zimadziwika. Pogwiritsa ntchito mankhwalawa muyezo waukulu, odwala ena adanenanso za kupezeka kwa zotumphukira zamitsempha, zomwe zimachitika atasiya kumwa mankhwalawa.

Kuchokera pamtima dongosolo: tachycardia, kuzungulira kwa magazi (kumawonekera kokha mwa odwala omwe ali ndi chidwi chamunthu).
Thupi lawo siligwirizana: kuyabwa pakhungu, zidzolo, urticaria, pamene kumwa Mlingo waukulu wa mankhwala odwala, kukula kwa ziphuphu kumadziwika.
Zotsatira zina zoyipa: cyanosis, edema ya m'mapapo, thukuta. Odwala omwe ali ndi vuto la hypersensitivity ku zigawo zikuluzikulu za mankhwalawo, zimachitika kuti anaphylactoid, kuphatikizapo edincke edema. Ndi kholo makonzedwe a mankhwala kwa odwala omwe ali ndi hypersensitivity mpaka B mavitamini, anaphylactic mantha angayambe.

Zoyipa:
Kuchulukitsa kumvetsetsa kwamunthu pazigawo za mankhwala.
Amalembedwa mosamala kwa odwala omwe ali ndi psoriasis, chifukwa cyanocobalamin ikhoza kuyipa mu psoriasis.
Mankhwala Neurorubin mu mawonekedwe a yankho la jakisoni sagwiritsidwa ntchito pa nthawi yoyembekezera komanso mkaka wa m`mawere, komanso kwa ana osakwana zaka 16.

Mimba
Mankhwala amawoloka chotupa cha hematoplacental ndipo amatsimikiza mkaka wa m'mawere. Palibe chidziwitso chokhudza chitetezo cha mankhwalawa panthawi yapakati komanso mkaka wa m`mawere. Mankhwala omwe ali ndi pakati amatha kuthandizidwa ndi adotolo ngati phindu lomwe mayi akuyembekeza limayesa chiwopsezo cha mwana wosabadwayo. Ngati ndi kotheka kuti mupeze mankhwalawa panthawi yoyamwitsa, ndikofunikira kusankha pakuletsa kuyamwitsa.

Mogwirizana ndi mankhwala ena:
Pogwiritsa ntchito munthawi yomweyo, mankhwalawa amachepetsa achire zotsatira za levodopa, zomwe ziyenera kuganiziridwa pochiza odwala omwe ali ndi matenda a Parkinson komanso kupewa kugwiritsa ntchito mankhwalawa munthawi yomweyo.
Pogwiritsa ntchito munthawi yomweyo, mankhwala a Neurorubin amathandizira poizoni wa isoniazid.
Neurorubin chifukwa cha Vitamini B6 imatha kuchepetsa kugwiritsidwa ntchito kwa altretamine pogwiritsa ntchito munthawi yomweyo.
Thiosemicarbazone ndi fluorouracil ndi otsutsana ndi vitamini B1.
Mankhwala okhala ndi envelopu ndi ma antacid amachepetsa kuyamwa kwa mankhwala Neurorubin-Forte Lactab.

Bongo
Ndi mankhwala osokoneza bongo odwala, kuwonjezereka kwa zovuta zoyipa kumadziwika.
Palibe mankhwala enieni. Pankhani ya bongo, chapamimba thonje ndi makonzedwe a enterosorbents akuwonetsedwa. Mankhwalawa ndi chizindikiro. Ndi kupanga anaphylactic mantha, glucocorticosteroids ogwiritsa ntchito mwadongosolo komanso antihistamines amagwiritsidwa ntchito.

Kutulutsa Fomu:
Mapiritsi, okutira-kanema, zidutswa 10 mu chithuza, matuza awiri mu bokosi lamatoni.
3 ml jakisoni yankho mu ampoule, ma ampoules asanu mu katoni.

Malo osungirako:
Mankhwala tikulimbikitsidwa kuti tisungidwe m'malo owuma kutali ndi dzuwa. Mapiritsi a Neurorubin-Forte Lactab akulimbikitsidwa kuti asungidwe pamtunda wa 15 mpaka 25 digiri Celsius.
Njira yothetsera jakisoni Neurorubin tikulimbikitsidwa kuti isungidwe pamtunda wa 2 mpaka 8 digiri Celsius.
Alumali moyo wa mankhwala mu mawonekedwe a yankho la jakisoni ndi zaka zitatu.
Alumali moyo wa mankhwala osokoneza mapiritsi ndi zaka 4.

Mawu:
Neurovitan, Milgamm.

Zopangidwa:
3 ml (1 ampoule) wa jakisoni muli:
Thiamine hydrochloride - 100 mg,
Pyridoxine hydrochloride - 100 mg,
Cyanocobalamin - 1 mg.
Othandizira.

Piritsi limodzi lachifundo 1
Thiamine mononitrate - 200 mg,
Pyridoxine hydrochloride - 50 mg,
Cyanocobalamin - 1 mg.
Othandizira.

Yang'anani!
Musanagwiritse ntchito mankhwala Neurorubin muyenera kufunsa dokotala. Bukuli limaperekedwa mwa kutanthauzira kwaulere ndipo cholinga chake ndi chidziwitso chabe. Kuti mumve zambiri, chonde onani zomwe akupanga.
Gwero la kufotokozera, malangizo ogwiritsira ntchito mankhwalawa (mankhwala): tsamba "Piluli - Mankhwala kuyambira A mpaka Z"

Kusaka zokha mitengo yabwino kwambiri ya mankhwalawo ndi mitundu yofananira nayo NEURORUBINE FORTE LACTAB N20 dinani apa:

• Zithunzi ndizongoganizira chabe. Zithunzi za mankhwala omwe ali patsamba lino zimatha kusiyana ndi mawonekedwe enieni.

Zotsatira za pharmacological

Mankhwalawa ali ndi mavitamini atatu omwe amathandizira ndikuthandizira zochita za wina ndi mnzake.

Vitamini B1, kapena thiamine, amatenga nawo mbali mokhudzika ndi kusintha kwa thupi monga coenzyme. Amagwiritsa ntchito poizoni wokhala ndi okhathamiritsa zida za metabolic - pyruvic ndi lactic acid. Amalamulira chakudya, mafuta ndi mapuloteni kagayidwe.

Thiamine amalimbikitsa kukopa kwa mathero a mitsempha, kusintha kagayidwe ka neurons. Amayendetsa matumbo kuyenda komanso kugaya chakudya. Imakhala ndi ma analgesic ofatsa kwambiri pamatalikidwe kwambiri.

Ndikusowa kwa vitamini B1, mathero amitsempha (polyneuritis) amakhudzidwa, kumva, Wernicke-Korsakov syndrome (ndi chidakwa) amakhala operewera.

Vitamini B6, pyridoxine - chinthu chomwe chimaphatikizidwa ndi mapuloteni komanso mafuta, mphamvu zama cell a mitsempha. Ndi coenzyme wa kusintha kwa ma amino acid m'chiwindi. Imalimbikitsa kuphatikizira kwa ma neurotransmitters ofunikira kwambiri komanso apakati amanjenje: adrenaline, norepinephrine, dopamine. Amakonza mkhalidwe wa chiwindi, amachepetsa mawonetseredwe a premenstrual syndrome mwa azimayi: kupweteka mutu, kutupa, komanso kuipiraipira kwa malingaliro. Amatenga nawo kapangidwe ka hemoglobin.

Ndikusowa vitamini B6, kutopa kwamanjenje, kutupa, kuchuluka kwa prolactin ya mahomoni, kuchepa kwa tsitsi, kusamba kwa msambo, komanso khungu.

Vitamini B12, cyanocobalamin - mankhwala omwe ali ndi chitsulo cobalt. Zimakhudza mapuloteni, mafuta kagayidwe. Chimalimbikitsa kugawa kwa maselo mwakuwongolera kaphatikizidwe kazinthu ma acid. Kuchulukitsa kuchuluka kwa maselo ofiira m'magazi, kutenga magawo awo chifukwa cha methylation process. Amachepetsa cholesterol yamagazi, homocysteine. Zabwino pachimake ndi zotumphukira mantha dongosolo. Imalimbikitsa njira yofananira yopweteketsa kupweteka m'malire a axonal.

Ndikusowa vitamini B12, kusokonezeka kwakukulu mu kugwira ntchito kwa msana, kuchepa magazi m'thupi, kuchuluka kwa bilirubin, cholesterol, homocysteine, ndi mafuta a chiwindi kumatha.

Ndikusowa kwa vitamini B12, kuchepa kwamafuta m'chiwindi kumatha kuchitika.

Pharmacokinetics

Mukamamwa pakamwa, thiamine amadziwidwa m'matumbo ang'ono ndipo amalowa m'chiwindi. Zina mwa izo zimasinthidwa mobwerezabwereza. Amapangidwa ndi kupukusidwa mwa mtundu wa thiamincarboxylic acid, dimethylaminopyrimidine. Pochulukirapo timatulutsidwa popanda mkodzo.

Pyridoxine hydrochloride, ikamamwa pakamwa, imagwira mwachangu ndipo imalowa m'chiwindi. Zimapangidwa kuti pyridoxalphosphate ndi pyridoxamine. Amamangirira kunyamula mapuloteni m'magazi ndikudziunjikira m'matumbo momwe amapangira pyridoxalphosphate. Amachotseredwa mu mawonekedwe a pyridoxic acid.

Cyanocobalamin imatengedwa ndi thupi chifukwa cha mtima mkati mwa Castle womwe umapezeka m'mimba - gastromucoprotein. Amamezedwa m'matumbo, omangidwa m'magazi ndi mapuloteni onyamula - transcobalamin ndi alpha-1-globulin. Imadziunjikira m'chiwindi, pomwe imatha kusungidwa mpaka chaka chimodzi. Hafu ya moyo wamwazi ndi masiku 5.

Matumbo

Kusanza, kusanza, kutentha pa mtima, kupweteka m'mimba.

Gwiritsani ntchito mu ukalamba

Imavomerezedwa kuti igwiritsidwe ntchito ngati atchulidwa ndi dokotala ndikuyang'ana zovuta zonse. Cyanocobalamin imawonjezera mamasukidwe amwazi, chifukwa chake imatha kuwonjezera ngozi ya thrombosis.

Cyanocobalamin imawonjezera mamasukidwe amwazi, chifukwa chake imatha kuwonjezera ngozi ya thrombosis.

Kuchita ndi mankhwala ena

Maantacid ndi ma sorbot amachepetsa kuyamwa kwa mankhwalawa. 6-fluorouracil, thiosemicarbazone - thiamine wotsutsana naye.

Vitamini B6 amachepetsa ntchito ya anti-Parkinsonia mankhwala Levodopa.

Vitamini B6 amachepetsa ntchito ya anti-Parkinsonia mankhwala Levodopa.

Ndemanga za Neurorubin Fort

Igor, wazaka 40, Samara

Ndinagula mavitamini azakudya za osteochondrosis. Kunali zopweteka m'khosi.Atamwa mankhwalawo, adafooka. Anayamba kumva kukoma kwambiri. Kufooka kudutsa m'mawa.

Anna, wazaka 36, ​​Kazan

Kudzera kwamiyendo ndi zala kunali kuda nkhawa. The neuropathologist adalamula mankhwala. Zizindikiro zinachepa. Mutatenga mapiritsi, panali kupweteka pang'ono, zotsatira zake zimawonetsedwa mu malangizo. Panali mutu.

Contraindication

Hypersensitivity mankhwala.

Vitamini B ₁ Amaphatikizidwa kuti agwiritse ntchito matupi awo sagwirizana.

Vitamini B ₆ Iwo contraindicated vuto la peptic ulcer m'mimba ndi duodenum mu pachimake siteji (popeza kuwonjezeka acidity wa chapamimba madzi ndikotheka).

Vitamini B ₁₂ Amapangidwa kuti agwiritsidwe ntchito mu erythremia, erythrocytosis, thromboembolism.

Njira zoyenera zotetezera

Chifukwa cha hypersensitivity ku mavitamini B ₁ , Mu ₆ ndi B ₁₂ pa mankhwala, zimachitika pakhungu ndi minyewa yofinya ingachitike.

Pyridoxine imatha kupangitsa kuti ziphuphu kapena ziphuphu zakhungu ziphuphu kapena kuti zizitha kuwonetsa zomwe zilipo.

Ndi kukhazikitsidwa kwa vitamini ₁₂ chithunzi cha chipatala, komanso mayeso a labotale a funicular myelosis kapena kuchepa magazi m'thupi, atha kutaya mawonekedwe awo.

Kumwa mowa ndi tiyi wakuda kumachepetsa kuyamwa kwa thiamine.

Kumwa zakumwa za sulphite (monga vinyo) kumakulitsa kuchepa kwa thiamine.

Chifukwa mankhwalawa ali ndi vitamini ₆ Iyenera kugwiritsidwa ntchito mosamala odwala omwe ali ndi mbiri yam'mimba komanso zilonda zam'mimba, zomwe zimafotokozedwa ndi kuwonongeka kwa impso ndi kwa chiwindi.

Odwala omwe ali ndi neoplasms, kupatula milandu yomwe imayendera ndi megaloblastic anemia ndi kuchepa kwa vitamini B ₁₂ sayenera kugwiritsa ntchito mankhwalawa.

Mankhwalawa amagwiritsidwa ntchito chifukwa cha mtima kapena kupweteka kwa mtima ndi ntchito za angina pectoris.

Gwiritsani ntchito pa nthawi yoyembekezera komanso mkaka wa m`mawere

Mankhwalawa amatchulidwa pokhapokha kuwunika mozama phindu / chiopsezo, popeza palibe kuchuluka kwa chitetezo cha mankhwalawa panthawi yapakati.

Mavitamini B ₁ , Mu ₆ ndi B ₁₂ chotsekedwa mkaka wa m'mawere. Kuzindikira Kwambiri Vitamini B ₆ ikhoza kuletsa kupanga mkaka. Kafukufuku wokhudza kuchuluka kwa mavitamini obisalira mkaka wa m'mawere sanachitike. Lingaliro la kusiya kuyamwitsa kapena kugwiritsa ntchito mankhwalawa liyenera kuchitika chifukwa chakuganizira za kumwa mankhwala kwa mayi. Ngati ndi kotheka, kugwiritsa ntchito mankhwalawa kuyenera kuyamwa kuyamwitsa nthawi imeneyi.

Kutha kukopa momwe zinthu zikuyendera mukamayendetsa magalimoto kapena njila zina

Mankhwalawa samakhudza kuyendetsa magalimoto kapena kugwira ntchito ndi makina.

Pa milandu yomwe chizungulire chimawonedwa pamankhwala, munthu ayenera kupewa kuyendetsa magalimoto ndikugwiritsa ntchito njira zina.

Ana sayenera kupatsidwa mankhwala, popeza palibe zomwe zingachitike ndi kugwiritsa ntchito ana.

Bongo

Vitamini B ₁ : ili ndi magulu osiyanasiyana achire. Mlingo wapamwamba kwambiri (woposa 10 g) amawonetsa kupindika, kupondereza kutsata kwa mitsempha.

Vitamini B ₆ : Ili ndi poizoni wotsika kwambiri. Kugwiritsa ntchito nthawi yayitali (kupitirira miyezi 6-12) muyezo wa 50 mg wa vitamini B ₆ tsiku lililonse kumatha kuyambitsa zotumphukira mphamvu neuropathy.

Kugwiritsa Ntchito Vitamini Kwambiri ₆ Mlingo woposa 1 g patsiku kwa miyezi ingapo ungayambitse matenda amitsempha.

Neuropathies omwe ali ndi vuto la ataxia ndi zamkati, kugwidwa kwa ubongo ndi kusintha mu EEG, komanso nthawi zina hypochromic anemia ndi seborrheic dermatitis adafotokozedwera pambuyo pakupereka kwa ≥ 2 g patsiku.

Vitamini B ₁₂ : Pambuyo pa makonzedwe a makolo (kawirikawiri, pambuyo pakukonzekera kwamlomo), zovuta zoyipa, kusokonezeka kwa khungu ndi mawonekedwe a ziphuphu anawonedwa pamlingo waukulu kuposa momwe analimbikitsira.

Kugwiritsa ntchito mankhwala yayitali kwa nthawi yayitali, kuphwanya ntchito ya michere ya chiwindi, kupweteka mumtima, ndi kuchepa kwa magazi.

Chithandizo cha kuledzera pakamwa: kuchotsetsa poizoni (kutsuka, kutsuka m'mimba), njira zochepetsera kuyamwa (kugwiritsa ntchito makala opaleshoni).

Zotsatira zoyipa

Kuchokera ku chitetezo chamthupi: Hypersensitivity zimachitika, anaphylactic mantha, anaphylactic mantha. Thupi lawo siligwirizana nthawi zambiri.

Kuchokera ku endocrine system: Kutulutsa kwa prolactin kumalepheretsa.

Kuchokera ku dongosolo lamanjenje: nkhawa, kugwiritsa ntchito nthawi yayitali (kupitirira miyezi 6-12) ya Vitamini ₆ Mlingo ≥ 50 mg tsiku lililonse, kungayambitse zotumphukira zamitsempha, kukwiya kwamanjenje, malaise, chizungulire, kupweteka kwa mutu.

Kuchokera pamtima: tachycardia, kugwa.

Pa mbali ya kupuma dongosolo, chifuwa ndi Mediastinum: cyanosis, pulmonary edema.

Kuchokera m'mimba: matenda am'mimba, kuphatikizapo mseru, kusanza, kutsegula m'mimba, kupweteka kwam'mimba, kuchuluka kwa madzi am'mimba.

Kuchokera ku chiwindi ndi chikhodzodzo: akamagwiritsa ntchito Mlingo wambiri, kuchuluka kwa glutamic acid-transmucosal transaminase (SGOT) mu seramu yamagazi.

Pa khungu ndi subcutaneous minofu: zotupa, zotupa pakhungu, kuphatikizapo pruritus, urticaria.

Mavuto ena: thukuta kwambiri, kumva kufooka, chizungulire, malaise.