Chofunika kwambiri ndi kutaya kapena amlodipine

Kuthamanga kwa magazi (BP) ndiye njira yotchuka kwambiri komanso imodzi mwazomwe zikuyambitsa imfa lero. Pankhaniyi, ndikofunikira kuyang'anira magazi nthawi zonse pomwa mankhwala a antihypertensive. Kuphatikizidwa kwa amlodipine kuphatikiza losartan ndi imodzi mwabwino kwambiri mpaka pano kuti muchepetse kuthamanga kwa magazi.

Amlodipine ndi losartan mwa iwo okha ndi zinthu zomwe zimagwira.

Amapezeka onse payekhapayekha komanso monga gawo la mapiritsi osakanikirana a "Lortenza", "Amzaar", "Lozap AM".

Njira yamachitidwe

• Limagwirira a zochita za losartan limagwirizana blockade wa angiotensin II zolandilira. Angiotensin II ndi vasoconstrictor wamphamvu ndipo, chifukwa chakuchepa kwa lumen ya mitsempha, kumabweretsa kuwonjezeka kwa magazi. Blockade of receptors imalepheretsa mphamvu yake kukhazikika kwa mtima ndikuyambitsa kutsika kwa magazi, kutsika kwa katundu pamtima, komanso kuchepa kwa kuthamanga kwa capillaries a impso. Kuphatikiza apo, losartan imalepheretsa kutulutsa kwa aldosterone - chinthu chomwe chimalimbikitsa kuti madzi asungidwe ndi sodium m'thupi, zimathandizanso kuchepetsa kuchuluka kwa magazi.
• Amlodipine amathandizira kuchepetsa mitsempha poletsa calcium ions kulowa maselo a minofu. Kuwonjezeka kwa lumen m'mitsempha yamagazi kumathandizira kuchepetsa kuthamanga kwa magazi, kuchepetsa katundu pamtima, kusintha magazi mu myocardium, ndikuchepetsa pafupipafupi kugunda kwa angina (kupweteka kumbuyo kwa sternum panthawi yolimbitsa thupi).

Pamodzi, mankhwalawa awiriwa samangoyambitsa kuchepa kwa kukakamizidwa, koma, kugwiritsa ntchito kosalekeza, kumabweretsa kuchuluka kwa chiyembekezo cha moyo mwa anthu omwe ali ndi matenda amtima.

Kugwiritsa ntchito amlodipine molumikizana ndi losartan kumasonyezedwa kwa matenda oopsa chifukwa cholephera kuchiza ndi mankhwala amodzi.

Contraindication

Kuphatikiza kwa mankhwala kumapangidwa motsutsana ndi:

• Kusalolera kwawo,
• Kutenga Alkisiren motsutsana ndi matenda a shuga kapena matenda aimpso,
• Zowopsa zaimpso,
• Kuphwanya kutuluka kwa magazi kochokera pansi pamtima (kuchepetsa kwa msempha kapena valavu),
• Kuchulukitsa kwa kulephera kwa mtima,
• Amawerengera kuchepa kwa kuthamanga kwa magazi,
• Mimba komanso kuyamwa
• Zaka mpaka 18.

Tulutsani mafomu ndi mtengo

Mitengo ya mankhwala osokoneza bongo a losartan ndi amlodipine ndi awa:

• Lozap AM:
  • 5 mg amlodipine + 50 mg losartan, 30 ma PC. - 47 p
  • 5 mg + 100 mg, 30 ma PC. - 550 r
• Lortenza:
  • 5 mg + 50 mg, 30 ma PC. - 295 r
  • 5 mg + 100 mg, 30 ma PC. - 375 r
  • 10 mg + 50 mg, 30 ma PC. - 375 r
  • 10 mg + 100 mg, 30 ma PC. - 385 tsa.

Losartan kapena Amlodipine - ndibwino?

Ngati palibe mavuto ndi impso, ndiye kuti muchepetse kukakamiza, ndibwino kusankha losartan. Kupanda kutero, yambani chithandizo ndi Amlodipine. Komabe, malinga ndi malingaliro apadziko lonse lapansi, ndibwino nthawi zonse kuchepetsa kupanikizika ndikuphatikizidwa kwa mitundu iwiri. Imodzi mwamphamvu kwambiri, yokhala ndi zotsutsana pang'ono ndi zotsatira zoyipa, ndi kuphatikiza kwa sartans (Losartan, Valsartan, Candesartan) ndi calcium Channel blockers (Amlodipine, Lacidipine, Lercanidipine). ACE inhibitors (Lisinopril, Perindopril) osakanikirana ndi calcium channel blocker angagwiritsidwe ntchito mofananamo. Chifukwa chake, kuyerekezera pakati pawo mwa mankhwalawa ndikosayenera.

Losartan ndi Amlodipine - kuphatikiza pamodzi

Funso la momwe angatengere mankhwalawa awiri limangodalira wodwalayo. Mulimonsemo, amakonda kupatsidwa mankhwala osakanikirana, omwe amaphatikiza mankhwala awiri nthawi imodzi - izi zithandizira moyo wa wodwalayo ndipo sizidzayambitsa "m'mawa muyenera kumwa mapiritsi ochepa". Mutha kusankha nokha mankhwala malinga ndi kuchuluka kwa kuthamanga kwa magazi ndi mtengo wovomerezeka. Tsopano mutha kupeza ma fanizo ambiri omwe angakuthandizeni kukwaniritsa zotsatira zabwino pochiza magazi. Makamaka, kuphatikiza kwa Amlodipine ndi Losartan kumapezeka pansi pa mayina "Lortenza", "Amzaar", "Lozap AM", "Amlotop Forte". Mankhwalawa amatengedwa piritsi limodzi nthawi 1 patsiku. Ngati kutupa pamiyendo ndikuda nkhawa, ndiye kuti muyenera kusankha mapiritsi omwe ali ndi Amlodipine ochepera komanso Losartan. Nthawi zina, onse mankhwalawa amasankhidwa payekhapayekha, kuyambira milingo yaying'ono, poganizira momwe kuchuluka kwa magazi kumatengera mankhwalawa.

Kuphatikiza apo, mitundu yonse yosakanikirana imapezeka kuchokera ku ACE inhibitor kapena sartan osakanikirana osiyanasiyana ndi calcium Channel blocker, diuretic (Indapamide, Hypothiazide) ndi / kapena statin (Atorvastatin, Rosuvastatin). Mapiritsi osiyanasiyana oterewa, omwe nthawi yomweyo amakhala ndi zinthu zitatu mpaka zinayi, amatha kusinthitsa moyo wa odwala omwe ali ndi matenda osokoneza bongo ndikusankha mankhwala oyenera.

Makhalidwe a Lozap

Ndi mankhwala omaliza a antihypertensive. Chosakaniza chophatikizacho ndi losartan potaziyamu. Zotsatira zakuchiritsira zimakhazikitsidwa pakutsutsana ndi zomangira za angiotensin 2. Siyoletsa ACE inhibitor. Imakhala ndi modabwitsa osasintha. Chifukwa cha izi, Lozap ali ndi mankhwala awa:

• amachepetsa kuchuluka kwa magazi a adrenaline ndi aldosterone,
• amachepetsa kupanikizika
• imalepheretsa kukula ndi kukulitsa kwa myocardium,
• kumawonjezera kukana kwa anthu omwe ali ndi matenda a mtima kuti azichita zolimbitsa thupi.

Wopezeka mu mawonekedwe a mapiritsi oyera ndi oyera omwe akumagawanika ndi Mlingo wa 12,5, 50 ndi 100 mg. The kuchuluka kwa mankhwala ndi yogwira metabolite m'magazi amapezeka 1 ola pambuyo makonzedwe.

Kodi amlodipine amagwira ntchito bwanji?

Gawo lalikulu la mankhwalawo ndi chinthu chomwe chimadziwika. Mankhwalawa amaletsa kuyenda kwa calcium ion kupita ku myocardium ndi maselo osalala a minofu. Imakhala ndi kupuma kwamphamvu pamitsempha yamagazi. Mankhwala a Amplodipine ali motere:

• amachepetsa kuopsa kwa myocardial ischemia mu angina pectoris,
• amakulitsa zotumphukira za arterioles,
• amachepetsa kuthamanga kwa magazi
• amachepetsa kulanda pamtima,
• kumawonjezera kuperekera kwa okosijeni ku myocardium.

Zotsatira zake, mtima umagwira ntchito bwino ndipo chiopsezo cha angina pectoris chimapewedwa. The achire zotsatira zimawonedwa mkati 6-10 maola.

Amplodipine amachepetsa kuopsa kwa myocardial ischemia ndi angina pectoris.

Kutulutsa mawonekedwe - mapiritsi okhala ndi mlingo wa 5 ndi 10 mg.

Kuphatikizika kwa Lozapa ndi Amlodipine

Mankhwalawa onse ali ndi vuto lodziletsa. Amplodipine amachepetsa mitsempha yamagazi ndikuchepetsa kukana kwawo. Lozap imalepheretsa matenda oopsa ndipo imalepheretsa kuti pakhale matenda a mtima. Chifukwa chake, kugwiritsa ntchito mapiritsi nthawi yomweyo kumachepetsa kuthamanga kwa magazi.

Momwe mungatenge Lozap ndi Amlodipine?

Dokotala akuyenera kufotokozera za nkhuku zakuthandizira ndi kuchuluka kwa mapiritsi atatha kuunika ndikuwunika zomwe wodwalayo apenda. Mlingo wovomerezeka umaloledwa kumwa mosasamala chakudya.

Chiwembu chomwa mankhwala molingana ndi malangizo:

• ku mavuto: Amlodipine (5 mg) + Lozap (50 mg) patsiku,
• matenda a mtima: 5 mg ya Amlodipine ndi 12,5 mg wa Lozap patsiku.

Mlingo ungathe kuwonjezeredwa ndi dokotala malinga ndi momwe matendawo aliri.

Zotsatira zoyipa

Mukagwiritsidwa ntchito limodzi, zotsatirazi zotsatirazi zingachitike:

• chizungulire
• kupweteka mutu kwambiri
• zosokoneza tulo
• tachycardia
• kutopa,
• chisangalalo
• kupuma movutikira
• mawonetseredwe a khungu lawo m'mayikidwe ake, kufiyira pakhungu, edema la Quincke,
• kukodza pafupipafupi
• anaphylactic mantha.

Zizindikirozi zikawoneka, mankhwalawa amayenera kuikidwa kaye ndikusaka uphungu. Ataona momwe zinthu ziliri, atha kuchepetsa kapena kutsata fanizo.

Malingaliro a madotolo

Kristina, wazaka 42, wazachipatala, Nizhny Novgorod

Mankhwala amatengeka mwachangu. Amathandizirana wina ndi mnzake, kukulitsa machiritso awo. Kuchita bwino kwa kuphatikiza kwawo kophatikizira ndikokwera kuposa ndi monotherapy. Ndi magwiridwe antchito a chiwindi ndi creatinine ndende ya 20 ml / mphindi. Sindikulimbikitsa kugwiritsa ntchito mankhwala osokoneza bongo. Mosamala, ndimawalembera anthu okalamba komanso munthawi yosagwira bwino ntchito yamtima.

Svetlana, wazaka 46, wamtima wazaka, Kazan

Kugwiritsa ntchito nthawi yomweyo kwamankhwala kumapereka mphamvu kuposa placebo. Chifukwa cha katundu wawo wothandizirana, kuthamanga kwa magazi kumachepera msanga ndipo zoopsa zomwe zingayambitse matenda ena a mtima ndi mtima zimapetsedwa. Ngati mumwa mankhwala ndi mlingo woyenera, ndiye kuti pafupipafupi zochita zimatsika.

Ndemanga za Odwala

Stepan, wazaka 50, mzinda wa St.

Ndakhala ndikuvutika ndi matenda oopsa kwa nthawi yayitali. Ndizotheka kukhazikika pokhapokha pokhapokha munthawi yomweyo Lozap ndi Amlodipine. Patatha ola limodzi mutamwa mapiritsiwo, mutu umatha ndipo kugunda kwamtima kumabwezeretseka. Ndimamwa mankhwalawa kutengera dongosolo lomwe adotolo adapereka. Zotsatira zake ndi zabwino.

Ekaterina, wa zaka 49, Omsk

Mayi anga ali ndi zaka 73, zipsinjozi zidayamba kukwera mpaka 140/80. Mapiritsi omwe adamulembera m'mbuyomu samathandizanso. Dotolo adatumiza limodzi kuti apange limodzi Lozap ndi Amlodipine. Zinali zowopsa kumwa mankhwalawa 2 nthawi imodzi, koma ndilofunika. Pakapita nthawi amayi atadwala matendawo. Tsopano timapulumutsidwa ndi mankhwalawa.

Khalidwe la losartan

Mankhwala a antihypertensive ndi osokoneza bongo a angiotensin II receptors. The zikuchokera mankhwala zikuphatikizapo yogwira mankhwala losartan potaziyamu ndi othandiza mbali: lactose, chimanga wowuma, talc.

1. Otayika m'mimba. Zotsatira zimatheka maola 6 pambuyo pa kukhazikitsidwa, mpaka maola 24. Amachotseredwa m'matumbo ndi impso.
2. Imathandizira kuchoka kwa madzimadzi, kutsitsa ochepa vasoconstriction komanso kumalepheretsa kusunga kwa sodium mthupi.
3. Amawonjezera kukana kwa thupi kuchita zolimbitsa thupi.
4. Zimalepheretsa chiwopsezo cha mtima kulephera pambuyo pa vuto la mtima.

• kulephera kwa mtima
• matenda oopsa
• matenda a ischemic.

Itha kugwiritsidwa ntchito molumikizana ndi mankhwala ena a antihypertensive, ndikuwonjezera mankhwala awo. Mlingo wophatikiza ndi potaziyamu mulimbikitsidwa.

Pa nthawi yomwe mayi ali ndi pakati, mankhwalawa amayenera kusiyidwa chifukwa chowopsa cha chitukuko ndi ntchito yofunika ya mwana wosabadwayo. Panthawi yoyamwitsa, muyenera kukana kugwiritsa ntchito mankhwalawo kapena muyenera kusiya kudyetsa.

Losartan imagwiritsidwa ntchito pochiza kulephera kwa mtima, matenda oopsa, kusokonezeka kwa ischemic.

Amlodipine kanthu

Mankhwalawa amachokera ku dihydropyridine ndipo ali ndi antianginal komanso hypotensive. Kuphatikizika kwamphamvu kwa ma isomers omwe amagwira ntchito kumapangitsa kuti calcium ikhale ndi minyewa yamaselo ochepa. Chifukwa chotsitsimutsa minofu yosalala yamitsempha yamagazi, kuchepa kwa kuthamanga kwa magazi kumachitika.

Yogwira pophika mankhwala amlodipine bwino magazi mu impso, amakulitsa main coronary mtsempha wamagazi ndi myocardial arterioles.

Mankhwala amachepetsa pafupipafupi matenda a angina, amawonjezera kutuluka kwa mpweya m'makoma ndi zimakhala za myocardium, ndikuletsa kukula kwa mawonekedwe a mitsempha ya coronary. The achire zotsatira zimachitika pambuyo 3 maola ndipo kumatha kwa tsiku limodzi.

Momwe mungatenge losartan ndi amlodipine palimodzi?

Mankhwala amatengedwa pakamwa kamodzi pa tsiku, piritsi limodzi la 5 mg ndi 50 mg, mosasamala kanthu za kudya. Nthawi zina mlingo wa tsiku ndi tsiku umatha kuchuluka mpaka 5 mg ndi 100 mg. Ndi vuto la mtima, mulingo woyenera kumayambiriro kwa mankhwalawa ndi piritsi 1/4 kamodzi patsiku. Odwala omwe amamwa mankhwalawa amatha kupatsidwa mankhwala osakanikirana omwe ali ndi mankhwala omwewo.

Katundu ndi makina ochitira

Zinthu zimadziwika ndi antihypertensive katundu. Amathandizana wina ndi mnzake, potero amalimbikitsa mphamvu. Thandizani pakukula kwa mitsempha yamagazi ndikuchepetsa makoma amitsempha yamanzere yam'mbuyo (matenda amayamba chifukwa chodumphira pafupipafupi mu kuthamanga kwa magazi). Kuphatikiza kwa zinthu kumayamwa bwino. Metabolism imachitika mu chiwindi.

Chifukwa chakuti losartan imakhudza RAAS ndipo imayambitsa zoletsa za antigenogeneis II, ndipo amlodipine ndi blocker wa njira yochepetsetsa ya calcium, zotchulidwa kwambiri zomwe zimadziwika.

Thupi limachokera ku dihydropyridine ndipo ndi wophatikiza modabwitsa wa ma isoma oyenda. Zimalepheretsa kulowa kwa calcium kukhala maselo amchere. Kutsika kwa kuthamanga kwa magazi kumachitika chifukwa chotsitsimutsa minofu yosalala ya ziwiya zamagetsi. Pankhaniyi, palibe zotsatira zoyipa pa myocardial contractility kapena atrioventicular conduction.

Kulowa mthupi, amlodipine amathandizira kusintha kwa magazi mu impso ndikuchepetsa kukana kwamitsempha.

Limagwirira zake amlodipine

Akatswiri adafufuza zingapo ndikupeza kuti mankhwalawa samakhudza kulolerana kochita masewera olimbitsa thupi, komanso kuchuluka kwa magazi a lipid mwa odwala omwe ali ndi vuto la mtima. Mutatha kumwa mankhwalawa, omwe amachokera pazinthu izi, zotsatira zake zimachitika pambuyo pa maola 2-3 ndipo zimatha tsiku limodzi.

Thupi limakhala lotsutsana ndi angiotensin receptor antagonists. Imatseka mokoma ma AS-1 receptors. Amathandizira kuchepetsa ochepa vasoconstriction komanso amalepheretsa madzi kusungunuka ndi sodium mthupi. Amagwiritsidwa ntchito pochiza matenda a mtima, matenda oopsa, matenda a ischemic. Thupi limalepheretsa kupita patsogolo kwa kulephera kwa mtima pambuyo poyambira.

Zimatithandizanso kukulitsa kulolera. Zotsatira zakugwiritsa ntchito mankhwala zimachitika pambuyo pa maola 5-6. Kuchepa kwake kumachitika mkati mwa maola 24. Losartan imalowa mu ziwalo za m'mimba. Amachotseredwa m'matumbo ndi impso.

Kugwirizana

Pamodzi, losartan ndi amlodipine nthawi zambiri amalembedwa, popeza kuphatikiza koteroko kumakhala ndi tanthauzo lotchulika, chifukwa chakuchepa kwa kukana kwa zotumphukira.

Popeza zimakhudza kuthamanga kwa magazi munjira zosiyanasiyana, zochita zawo zimalimbikitsidwa ndipo zotsatira zake zimabwera mwachangu kwambiri. Kuphatikiza uku kumawonedwa kukhala kotetezeka kwa odwala.

Mankhwala osakanikirana (omwe pano amatchedwa LP), omwe akuphatikizira zonse ziwirizi, amasintha luso la mankhwala pozindikira kulephera kwa mtima (mtima kulephera), angina pectoris, infarction ya ubongo ndi mtima. Ndi kugwiritsa ntchito munthawi yomweyo, chiopsezo cha kuwonetsa kusintha kwa thupi m'njira zithandizo chimachepetsedwa kwambiri.

Chothandiza kwambiri ndi chiyani?

Popeza zinthu zonsezi zimakhala ndi antihypertensive katundu, odwala nthawi zambiri amafunsa kuti ndibwino. Kwenikweni, kuyankha kumakhala kovuta. Chowonadi ndi chakuti ali m'magulu osiyanasiyana ndipo amathandizira kuti magazi azithamanga, ndipo amatithandizanso.

Zinthu izi zimagwiritsidwa ntchito pophatikiza kuti zitheke kukwaniritsa zabwino. Zimathandizira zochita za wina ndi mnzake ndikuthandizira kuchira.

Zizindikiro zogwiritsidwa ntchito

Kodi chimathandiza Lozap ndi chiyani? Mankhwalawa amagwiritsidwa ntchito pazovuta zotere:

• kuthamanga kwa magazi
• kulephera kwa mtima,
• pofuna kupewa matenda a mtima ndi mtima, makamaka kwa anthu omwe akudwala matenda oopsa.

M'malo mwake, mankhwalawa amagwiritsidwa ntchito kuti magazi akhale ochepa.

The zikuchokera mankhwala

Mankhwalawa amapezeka mu mawonekedwe a mapiritsi, omwe amaphatikiza ndi chipolopolo. Yogwira ntchito ya mankhwalawa ndi losartan potaziyamu. Komanso, momwe zimapangidwira zimaphatikizapo zinthu zothandiza:

Lozap amagulitsidwa ku pharmacies popanda mankhwala. Mtengo wapakati wamankhwala ku Russia ndi ma ruble 240. Mtengo wa ku Ukraine wa Lozap ndi 110 UAH.

Malangizo ogwiritsira ntchito mankhwalawa

Momwe mungatengere Lozap molondola? Ngati munthu akudwala matenda oopsa, ndiye kuti ayenera kumwa piritsi limodzi patsiku. Kutalika kwa chithandizo sikuyenera kupitirira miyezi isanu ndi umodzi. Mlingo wambiri watsiku ndi tsiku ndi mapiritsi awiri, ngati zotsatira zomwe mukufuna sizikwaniritsidwa.

Momwe mungamwe mankhwalawa chifukwa cha mtima kulephera kwa matenda osakhazikika? Mlingo wa tsiku ndi tsiku wa odwala oterewa ndi gawo limodzi la piritsi, lomwe linagawika 4. Kutalika kwa mankhwalawa sikuyenera kupitanso masabata atatu.

Momwe mungatengere Lozap: m'mawa kapena madzulo? Izi sizofunikira kwenikweni, koma odwala ambiri oopsa amakonda kugwiritsa ntchito mapiritsi a Lozap m'mawa. Zimathandiza kumva bwino tsiku lonse.

Ndikofunikira kukumbukira! Phalelo liyenera kutsukidwa ndi madzi ambiri osafuna kutafuna! Chifukwa cha izi, mankhwalawa amakhala ndi zotsatira zake mwachangu.

Lozap ndi mowa: kuyanjana

Odwala ambiri oopsa sawona vuto lililonse pakumwa mowa limodzi ndi kumwa mankhwalawa, potengera momwe awonera. Koma kodi ndizotetezeka? Tisaiwale kuti ethanol ili m'magazi tsiku lonse. Izi zikutanthauza kuti mukamwa mankhwalawa, mumakomoka ndimowa. Izi zimawonetsedwa ndi kuchepa kowopsa komanso kwamphamvu kwa kuthamanga kwa magazi. Wodwalayo amayamba kuona zizindikiro ngati izi:

• chizungulire chachikulu,
• kufooka kwa thupi,
• nseru kwambiri, nthawi zambiri zimayambitsa kusanza,
• kulumikizana bwino
• kuzirala kwa malekezero akumtunda ndi otsika.

Anthu ambiri omwe amamwa mankhwalawa amati izi zidakwa. M'malo mwake, izi ndizotsatira zamgwirizano wa ethanol ndi mphamvu yogwira ya mankhwala m'magazi. Chifukwa chake, kumwa mowa panthawi ya mankhwala ndi Lozap sikungathandize.

Zotsatira zoyipa za mankhwalawa

Nthawi zambiri, kugwiritsa ntchito chida ichi sikuyambitsa zosasangalatsa. Koma mwakugwiritsa ntchito kwambiri, ndiye kuti, ndi mankhwala osokoneza bongo, zovuta zotere zimatha kuonedwa:

1. Kuchokera kumbali yamanjenje: migraine, chizungulire, kusokonezeka kwa tulo, kusocheretsa pakamwa, ndi kuwonongeka kwa makutu.
2. Kuchokera pakupuma dongosolo: bronchitis, rhinitis ndi matenda ena amtundu wa kupuma.
3. Kuchokera m'mimba thirakiti: kupweteka kwam'mimba, kudzimbidwa kapena kutsegula m'mimba, kunyansidwa pang'ono, nthawi zina ndi kusanza, ludzu.
4. Kuchokera ku minculoskeletal system: kupweteka kumbuyo, miyendo, kukokana. Nthawi zina, nyamakazi imayamba.
5. Kuchokera pamtima dongosolo: hypotension, mtima palpitations, angina pectoris, magazi.
6. Kuchokera ku genitourinary system: mavuto ndi potency mwa amuna, operewera aimpso.

Mavuto azaumoyo omwe ali pamwambawa amawonedwa nthawi zambiri.

Ndikofunikira kukumbukira! Zimafunika kutsatira mosamalitsa malangizo ogwiritsa ntchito, komanso nthawi yoika dokotala! Izi zikuthandizani kupewa mavuto oyipa.

Lozap ndi Lozap kuphatikiza: amasiyana bwanji?

Lozap Plus ndi mankhwala ophatikiza omwe ali ndi zochita zosiyanasiyana. Kusiyana kwakukulu kwa chida ichi ndikuti ili ndi zinthu zingapo zomwe zikugwira ntchito. Lozap yokhazikika ili ndi chophatikizira chimodzi chokha. Amasiyananso pamtengo: Lozap kuphatikiza ndiokwera kawiri kuposa mankhwala wamba.

Prestarium kapena Lozap

Prestarium nthawi zambiri imagwiritsidwa ntchito pazovuta zazikulu, komanso kutsekeka kwa kayendedwe ka mtima. Imeneyi ndi njira yothandiza mukamakonzanso matenda a mtima. Imakhala ndi zotsatila zambiri, koma mumalimbana ndi kuthamanga kwa magazi. Ndi analogue wotsika mtengo.

Lozap kapena Noliprel

Kupanga kwa Noliprel kumaphatikizapo magawo awiri ogwira ntchito omwe ali ndi nthawi imodzi. Chifukwa chake, sichimangochepetsa chizindikiro, komanso chimakhala ndi phindu pa mtima.

Musanasankhe njira yeniyeni yochizira matenda oopsa, muyenera kufunsa dokotala, chifukwa ma pharmacology amakono amapereka mankhwala ambiri.

Kunena kuti ndi mankhwala ati "Amlodipine" kapena "Lorista" ali bwino ndikovuta, chifukwa ali m'magulu osiyanasiyana a mankhwala ndipo nthawi zambiri amapatsidwa mankhwala osokoneza bongo. Koma pali kusiyana kwakukulu. Mwachitsanzo, mphamvu ya Amlodipine imathamanga, chifukwa chake, mankhwalawa amagwiritsidwa ntchito kuti athetse vuto la matenda oopsa, pomwe mapiritsi a Lorista amagwira ntchito kwa nthawi yayitali. Koma kuti mufananitse mankhwala onse awiri, muyenera kuganizira zambiri za iwo mwatsatanetsatane.

Kodi mankhwalawa ndi ofanana?

"Amlodipine" ndi "Lorista", monga akufotokozera pamwambapa, ndi mankhwala ochokera m'magulu osiyanasiyana a antihypertensive mankhwala. Ma calcium calcium blockers amachepetsa kupanikizika pakukulitsa mitsempha, ndiye kuti, mwa kuchepetsa kukana kwawo. Mankhwalawa amalepheretsa magazi kuundana ndikuletsa chitukuko cha atherosulinosis, kukulitsa kupirira kwamthupi, ndikuwonetsa zotsatira zabwino mwa okalamba. Chifukwa chake, zochita za sartan zimalepheretsa zolandilira za angiotensin II ndipo sizimalola kuti timadzi timene timayambitsa matenda oopsa. Angiotensin II receptor blockers amaphatikizidwa pochiza matenda osagwirizana ndi matenda oopsa, osayambitsa chifuwa chowuma komanso matenda achire, amagwira bwino ntchito ku matenda a impso. Chifukwa chake, munthu sanganene kuti zomwe zakonzedwazo ndi zofanana, chifukwa cha magwiridwe antchito komanso kusiyana kwakukwaniritsa.

Zizindikiro zogwiritsidwa ntchito

Kuwonjezeka kwa kuthamanga kwa magazi kopitilira 140 ndi 90 mm RT kumawerengedwa kuti ndi matenda. Art., Ndipo ngati kupanikizika kuli 160 mpaka 90 mm RT. Art. ndipo pamwamba, kuikidwa kwa antihypertensive mankhwala ndikofunikira. "Amlodipine" imagwiritsidwa ntchito makamaka mwa okalamba omwe ali ndi matenda amtundu wa mitsempha, arrhythmias, angina pectoris. Lorista ndi mankhwala osankhidwa mwa odwala omwe ali pachiwopsezo cha matenda amtima ndi matenda ashuga. Ndikofunikira kudziwa kuti monotherapy imagwira ntchito pokhapokha gawo loyambitsa matenda oopsa. Chifukwa chake, makamaka mankhwalawa, kuphatikiza kwa mankhwala angapo ochokera m'magulu osiyanasiyana kumagwiritsidwa ntchito. Komanso, njirayi imakuthandizani kuti muchepetse mavuto obwera chifukwa cha mankhwala ndikuwongolera machitidwe onse a mapangidwe a kuthamanga kwa magazi.

Ndi mankhwala ati omwe ali bwino, Amlodipine kapena Lorista?

Kutengera pa kafukufuku wa odwala omwe adamwa mankhwalawa onse, Amlodipine amachita mwachangu, kukakamiza kumatsika kumanambala ofunikira ndikukhalanso okhazikika pambuyo pa kumwa koyamba, osati patatha masiku angapo, monga momwe anachitira a Lorista. Mankhwalawa amatha kugwiritsidwa ntchito bwino, ndipo nthawi zambiri amawapangira limodzi pochiza matenda oopsa kapena oopsa, osagwirizana ndi matenda oopsa. Koma kuwunikira kwathunthu chithunzi cha matenda, poganizira zovuta, njira zamankhwala, mawonekedwe a wodwala, ndi dokotala yekha amene angatero. Chifukwa chake, mankhwala ayenera kuvomerezedwa nthawi zonse ndi katswiri kapena wamtima.

Zochokera pa intaneti

Pazaka makumi angapo zapitazi, kuchuluka kwa anthu omwe ali ndi matenda amtima wamatenda akula kwambiri. Kupsinjika kowonjezereka kwakhala gawo lodziwika bwino m'moyo. Chifukwa cha kuchuluka kwa mitsempha, matenda oopsa, kulephera kwa mtima, ndi zochitika zina zosasangalatsa zikuchitika. Kuti muthane nawo, akatswiri a zamankhwala akupanga zida zatsopano komanso zowoneka bwino. M'modzi mwa iwo ndi Lozap. Monga mankhwala ambiri, ili ndi ma contraindication omwe amayenera kuwonedwa. Koma pali mgwirizano wanji wa mankhwalawo ndi mowa, ndipo titha kuyankhula za kuyanjana kwa Lozap ndi mowa?

Zinthu ndi cholinga cha mankhwalawa

Lozap amapangidwa ku Czech Republic ndi Slovakia. Mankhwala amapezeka mu mawonekedwe a biconvex elongated splitting mapiritsi, wokutira ndi chipolopolo choyera.

Lozap ndi mankhwala aposachedwa kwambiri a antihypertensive. Malo achire amachokera pamalingaliro okakamira a angiotensin receptors 2. Amakhala ndi diuretic. Chofunikira chachikulu ndi potaziyamu losartan. Monga othandizira - mannitol, magnesium stearate, crospovedin ndi ena.

Mankhwala amatengedwa pakamwa, kamodzi patsiku. Palibe njira zofunikira pakudya, chifukwa chakuti palibe zochitika zolembedwa zokhudzana ndi kuchuluka kwa mayamwidwe ndi kuchiritsa kwa iwo.

Mankhwala sakugulitsidwa, mukufunika kugula mankhwala kuti mugule. Iyenera kusungidwa pamtunda osapitirira 30 ° C, kutetezedwa ndi dzuwa. Alumali moyo wa mankhwala 2 zaka.

Mankhwala a antihypertensive ali ndi izi:

• Amatha kuchepetsa magazi ambiri a adrenaline ndi mahomoni a aldosterone.
• Kuchepetsa kupsinjika kwa kufalikira kwa m'mapapo.
• Khalani ndi diuretic tingati.
• Pewani kukula komanso kukulitsa kwa myocardium.
• Kuonjezera kukana kwa anthu omwe ali ndi mavuto amtima kuti azichita zolimbitsa thupi.

Mphamvu yayikulu yochepetsera kupanikizika imachitika patatha maola 6 mutadwala kamodzi. Pambuyo pake, masana zinthu zimachepa pang'onopang'ono. Ndi dongosolo la mankhwala, kutsika kwakukulu kwa kuthamanga kwa magazi kumachitika masabata 3-6 itatha yoyamba mlingo.

Kuyamwa kwa zinthu za mankhwala kuchokera m'matumbo am'mimba kumachitika mwachangu. Monga lamulo, pafupifupi 33% ya zinthu zimagwidwa ndi thupi. Kuphatikizika kwa madzi am'magazi kumafikira pakatha ola limodzi mutamwa mapiritsi. Chiwerengero chachikulu cha metabolites chimapangidwa pambuyo pa maola 3-4. Mankhwalawa amachotseredwa m'matumbo (pafupifupi 60%) komanso ndi mkodzo (pafupifupi 35%) kwa maola 2-9.

Lozap akuwonetsedwa kuti asankhidwa:

• Ndi kuthamanga kwa magazi.
• Kulephera kwamtima kosalekeza. Milandu iyi, mankhwalawa amawonetsedwa ngati gawo lachithandizo chokwanira pomwe wodwala akapezeka kuti sangalole zigawo zina za mankhwala, kapena sizingatheke.
• Pofuna kupewa matenda a mtima (kuphatikizapo stroke).
• Pankhani ya nephropathy komanso kuthamanga kwa magazi kwa odwala omwe ali ndi matenda a shuga a 2.

ku nkhani zake ↑ Contraindication ndi zotsatira zoyipa

Monga mankhwala aliwonse, mankhwalawo ali ndi malire ake pakubadwa, sangathe kutengedwa milandu:

Poyerekeza ndi kuunika kwachipatala, mukamalandira mankhwala, zotsatira zoyipa sizimachitika. Ngati adapezeka, ndiye kuti ndi achikhalidwe chochepa. Chifukwa chake, palibe chifukwa chochotsa mankhwalawo ndikusokoneza chithandizo.

Nthawi zina, zinthu zotsatirazi zingaoneke:

• Kutopa, kupweteka mutu, nthawi zina chizungulire, kusokonezeka kwa kugona, matenda a kutopa kwambiri. Madokotala olemba osakwana 1% ya odwala mawonekedwe a kugona, kukumbukira pang'ono, kumva, kuwonongeka kwa mawonekedwe, mkhalidwe wamavuto amisala, komanso mutu waching'alang'ala.
• Nthawi zina, bronchitis kapena rhinitis imatha, ndipo zizindikiro za chapamwamba matenda kupuma thirakiti zitha kuonekera.
• Kupukusa m'mimba (kutsegula m'mimba kapena kudzimbidwa), kupweteka kwam'mimba, kusanza, pakamwa kowuma.
• Ululu kumbuyo, mapewa ndi miyendo, kukomoka kumachitika. Palinso milandu yowonjezera nyamakazi.
• Lozap ikhoza kukulira potency, kusokoneza ntchito ya impso.
• Zizindikiro zochepa zimaphatikizanso kutuluka thukuta, thupi lake siligwirizana.

Mankhwala osokoneza bongo atha kufotokozedwa motere:

• Kuchepetsa kwambiri kuthamanga kwa magazi.
• Maonekedwe a tachycardia.
• Bracardia (kuchepa kwa kugunda kwa mtima mpaka 3040 kumenyedwa / mphindi.).

Kuchotsa izi, kukakamiza kukodzetsa kumagwiritsidwa ntchito (kukondoweza pokodza limodzi ndi madzi amodzimodzi amadzimadzi ndi chimbudzi), monga mankhwala othandizira.

Zamkati ↑ Ubwenzi ndi mowa: Nkhani zogwirizana

Odwala ena sawona cholakwika chilichonse ndikumwa mankhwalawo ndikumwa mowa nthawi yomweyo. Kutengera kokha pazomwe akudziwa, amakangana kuti mutha kuzigwiritsa ntchito ngati sichoncho nthawi yomweyo, kenako patsiku limodzi.

Komabe, tiyenera kukumbukira kuti mankhwalawa atagwiritsidwa ntchito ali m'magazi kwa tsiku limodzi, kuti akwaniritse kuchiritsira kwake kuyenera kumwa kwa nthawi yayitali. Izi zikutanthauza kuti nthawi yonseyi zimachitika ndi woledzera. Kuphatikiza apo, ngati odwala ena anali ndi mwayi ndipo popanda zotsatira zoyipa, izi sizitanthauza kuti anthu enanso adzakhala ndi mwayi. Chifukwa chake, khazikikani pakulingana, ndipo makamaka mulangizeni, osalabadira.

Lozap, komanso Lozap Plus, ofanana nayo, ndi mankhwala a antihypertensive, ndiye kuti, mankhwala opangidwa kuti achepetse kuthamanga kwa magazi. Zachilendo zawo zili munthawi yogwiritsa ntchito, ndiye kuti, zinthu zomwe zimagwira ntchito zimakhala m magazi nthawi zonse ndipo zimagwira. Chifukwa chake, munthawi yamankhwala, chisamaliro chimayenera kuyang'aniridwa popewa kupewa kwa zinthu zomwe zingasemphane nawo ndikupereka zotsatira zosayembekezereka.

Izi zimakhudza kwambiri mowa wa ethyl, womwe umapezeka mu zakumwa zonse zamankhwala, komanso ma tinctures a mankhwala ndi zina. Chifukwa chake, funso loti ngati ndizotheka kumwa mankhwala a Lozap kapena Lozap Plus nthawi yomweyo mowa sizikhudzanso okhawo omwe adzachite chikondwerero chilichonse.

Amadziwika kuti atalowa m'magazi, mowa umalimbikitsa kukulitsa mitsempha yamagazi. Ndipo ngati mankhwalawo akhudzidwa kale ndi thupi, mowa umatha kusintha zolakwika zake. Kuchulukanso kwamitsempha yamagazi kudzachitika, komwe kumapangitsa kutsika kwamphamvu kwa mtima komanso kutsika kwamphamvu kwa magazi. Kupanikizika kumatha kugwa kwambiri, msinkhu wake udzakhala wotsika kwambiri.

• Chizungulire
• Kufooka mwadzidzidzi
• Kuchepetsa mseru
• Kuperewera kwa mgwirizano
• Kuzizira kwamiyendo.

Kuphatikiza apo, kukhazikika kwa kugwa kwa orthostatic, komwe kumayambitsa magazi osakwanira kuubongo, sikutsutsidwa. Zimachitika pang'onopang'ono posintha thupi, komanso kuyimilira nthawi yayitali.

Mukamacheza ndi mowa, zotsatira za adrenomimetic zimatha kukula: kutulutsidwa kwa adrenaline ya mahomoni kumachitika. Izi zipangitsa kugunda kwamtima mwachangu, kuchuluka kwa magazi, komanso kuchulukitsa kutsekeka kwa glycogen, komwe kumakulitsa shuga. Kuphatikiza apo, padzakhala cholepheretsa kugaya chakudya.

Zovuta za mowa zimathanso kukodza. Idzachulukana, zomwe zimachepetsa mphamvu ya mankhwalawa komanso nthawi yayitali yokhudza thupi.

Malangizo a mankhwalawa akuti ayenera kuthandizidwa mosamala ndi anthu omwe ali ndi vuto lodana ndi cirrhosis, popeza kuchuluka kwa zinthu zomwe zimagwira m'ziwalo zimachulukana kwambiri. Chifukwa chake, mlingo wa mankhwalawa uyenera kusinthidwa kutsikira. Mowa woledzera, kuwonjezera pa zovuta zake za thupi, umapangitsa kuti pakhale mankhwala ambiri.Ndikosavuta kulosera zomwe zingakhale ndi zotsatilapo zaumoyo, ngakhale moyo.

Muyenera kumwa mankhwalawa mosamala kwa anthu omwe ali ndi matenda a impso. Pa mankhwala, ndikofunikira kuwunika pafupipafupi zomwe zili mu potaziyamu. Choyamba, izi zimakhudzanso odwala okalamba.

Mulinso Lozap Plus

M'mafakitala palinso chida chatsopano kwambiri - Lozap Plus. Zimapangidwa ndi opanga omwewo. Miyezo yoyendetsera, zochita za mankhwala, yosungirako ndi moyo wa alumali ndizofanana. Mutha kusiyanitsa mapiritsi a Lozap Plus akunja, atakulungidwa ndi chipolopolo china - chikasu.

Mankhwala omwe Lozap Plus ali nawo kuwonjezera pa potaziyamu losartan, chinthu chachiwiri chogwira ntchito ndi hydrochlorothiazide, yomwe imakhala ndi diuretic. Mapangidwe onse awiriwa amalimbikitsana zomwe akuchitirana, mwakutero akwaniritsa gawo lalikulu pochepetsa kuthinana kuposa njira zakale.

Chifukwa cha diuretic kanthu, hydrochlorothiazide:

• Pang'onopang'ono kumawonjezera kuchuluka kwa uric acid m'madzi am'magazi.
• Kuchulukitsa mphamvu ya renin.
• Amachepetsa kuchuluka kwa potaziyamu.

Chifukwa cha kukhalapo kwa hydrochlorothiazide, pali zina zowonjezera zogwiritsidwa ntchito ndi Lozap Plus: imaphatikizidwa mu anuria (kusowa kwamkodzo) ndi hypovolemia.

Zaka makumi angapo zapitazi, chiwerengero cha anthu odwala matenda a mtima komanso kuthamanga kwa magazi chakwera kwambiri. Chimodzi mwazifukwa ndi kupsinjika kwakanthawi komanso moyo wovuta. Pofuna kuthana ndi mavuto amanjenje, njira zosiyanasiyana zimagwiritsidwa ntchito: kuchokera ku mowa kupita kumasewera owonjezera. Komabe, ziyenera kukumbukiridwa kuti ndizosatheka kuphatikiza chithandizo ndi mowa. Mowa, pakukhala wokha wokwiyitsa thupi, umasintha kusintha kwa mankhwalawo mthupi, ndipo umatha kupereka zotsatira zosayembekezeka. Choyipa chopweteketsa kwambiri chomwe chingakhale - kuwononga nthawi yothandizidwa.

Lozap imatchulidwa ngati mankhwala a antihypertensive. Mothandizidwa ndi mankhwala, matenda oopsa, komanso matenda oopsa mu ventricle yamanzere, amathandizidwa. Mankhwalawa amaloledwa bwino ndi thupi, omwe amalola kuti azigwiritsidwa ntchito pochiza odwala osiyanasiyana.

Pazaka zingapo zapitazi, kuchuluka kwa anthu omwe ali ndi mavuto azaumoyo, omwe ndi mtima wam'mimba, wakula kwambiri. Kupsinjika, lero, ndi gawo lodziwika bwino m'moyo. Njira zatsopano zikupangidwira kuthana ndi matenda otere. Mankhwala Lozap ali pamndandanda. Monga mankhwala ambiri, ili ndi ma contraindication omwe amayenera kuwonedwa.

Zochizira

Kuti muwonetsetse kuti achire kwambiri, wodwalayo akulimbikitsidwa kuti agwiritse ntchito mankhwala achikhalidwe mogwirizana ndi malangizo. Ngati wodwala wapezeka ndi matenda oopsa, ndiye kuti mankhwalawo ayenera kugwiritsidwa ntchito kawiri pa tsiku. Mlingo umodzi wa mankhwalawa umaperekedwa ndi adokotala.

Ngati matenda oopsa agwiritsidwa ntchito mokwanira ndi okodzetsa, ndiye kuti mankhwalawo amayenera kumwedwa kamodzi patsiku, komanso ndi mlingo womwe adokotala adapereka. Ngati wodwala wadwala matenda a mtima, ndiye kuti mankhwalawo amachitika pogwiritsa ntchito njira yapadera, yomwe imafunikira kuti chiwonjezerocho chiwonjezeke.

Ngati chithandizo cha matenda ashuga chikuchitika limodzi, ndiye kuti mankhwala amachitika poganizira za munthu payekha. Mlingo wamba wa tsiku ndi tsiku ndi wodwala. Ngati ndi kotheka, wonjezerani. Munthawi zonsezi, njira zochiritsira ziyenera kukonzedwa ndi adokotala, kutengera kuopsa kwa matenda.

Ngati kuchuluka kwa magazi kwa wodwala kuchepetsedwa, ndiye kuti nthawi yoika mankhwalawo iyenera kuchitika mosamala momwe angathere. Mlingo wochepetsedwa wa mankhwalawa uyenera kuchitika ngati wodwala ali ndi matenda a chiwindi kapena matenda enaake. Ndi matenda a shuga ndi matenda osachiritsika a ziwalo monga chiwindi ndi impso, chithandizo chikuyenera kuchitika ndi kuyang'aniridwa ndi dokotala kosalekeza.

Nthawi zambiri, thupi la munthu limalekerera mankhwalawo ndikumwa mankhwala ena. Izi zimathandiza kuchiza matenda oopsa. Ngati fluconazole kapena rifampicin amagwiritsidwa ntchito nthawi yomweyo ndi mankhwalawa, ndiye kuti kuchepa kwa kuchuluka kwa zinthu zake zothandizika kungawonedwe. Kutulutsa kwa mankhwalawa, kumaloledwa kugwiritsidwa ntchito pochiza matendawa kwa zaka 5.

Mndandanda wa mankhwala okhala ndi zinthu izi

Kuphatikiza kwa zinthu izi kumapereka mankhwala angapo nthawi imodzi, omwe ali ndi kachitidwe kena kofananira pa thupi ndipo amathandizira kuti magazi achulukane. Zitha kusiyana pamndandanda wina wazinthu zowonjezera komanso mtengo wake.

Zinthu zonsezi zitha kuwoneka m'mankhwala awa: Amozartan, Lortenza, Lozap AM, Amzaar. Mankhwala omwe adalembedwera amalembedwa kwa odwala omwe ali ndi vuto la mtima.

Akatswiriwa amawona kuti Lortensa, Amzaar, ndi Lozap AM ndiwothandiza kwambiri pamankhwala ophatikizidwa omwe alipo. Mankhwala amatithandizanso kuthamanga kwa magazi komanso kupewa kutulutsa zovuta.

Amalandira odwala omwe chithandizo chawo chimafuna kugwiritsa ntchito mitundu yophatikiza. Mankhwala osakanikirana ndi othandiza kwambiri kuposa monotherapy. Ngakhale kuti mankhwalawa ndi fanizo, amadziwika ndi zinthu zingapo ndipo amasiyana pang'ono.

Mankhwala ophatikizidwa amapitilizidwa kugwiritsidwa ntchito ngati mapiritsi okhala ndi mitundu yosiyanasiyana.

Mtundu wa mapiritsiwo umatengera mlingo:

• 5 mg + 50 mg. Piritsi limodzi lili ndi 6.94 mg wa amlodipine besylate ndi 163,55 mg wa losartan (bulauni wowala),
• 10 mg + 50 mg. Chiwerengero cha zigawo zikuluzikulu za piritsi limodzi ndi 13.88 mg wa amlodipine ndi 163,55 mg wa losartan (brown-red),
• 5 mg + 100 mg (6.94 mg / 327.1 mg, mapiritsi a pinki),
• 10 mg + 100 mg: 13.88 mg / 327.1 mg (yoyera ndi pang'ono tint wachikasu).

Zimalowa mthupi, zigawo zam'mapulogalamu zimayamba kugwira ntchito. Imodzi imafinya mitsempha yamagazi, ndipo yachiwiri imakhudza RAAS. Zotsatira zake, pali kuchepa kwa kuthamanga kwa magazi. Mtengo wapakati ndi ma ruble 300.

Mankhwala amapezekanso monga mapiritsi ogwiritsira ntchito pakamwa, mtundu wake womwe umatengera kapangidwe kake. Piritsi limodzi loyera lili ndi 50 mg ya losartan ndi 5 mg ya amlodipine. Piritsi yapinki imakhala ndi 5 mg ya amlodipine ndi 100 mg ya losartan. Kukonzekera kumaphatikizaponso zinthu zothandiza: sodium carboxymethyl starch, microcrystalline cellulose, titanium dioxide, magnesium stearate, hypromellose, talc. Mapiritsiwa ndi zokutidwa ndi filimu.

Amzaar pofotokoza algorithm

Mankhwala ali ndi kutchulidwa kwenikweni. Amawerengera odwala omwe ali ndi vuto losakanizira matenda oopsa. Mtengo wa mankhwalawa ndi ma ruble 590.

M'mafakitala aku Russia, amagulitsidwa monga mapiritsi. Chida ichi chimapezekanso mosiyanasiyana:

• 5 mg ndi 50 mg
• 5 mg ndi 100 mg.

Mndandanda wazinthu zina zowonjezera zimaphatikizapo: microcrystalline cellulose, titanium dioxide, mannitol, crospovidone, magnesium stearate.

Wophatikiza ndi wa gulu la mankhwala omwe amalepheretsa njira zama calcium ndikuchita ngati angiotensin receptor antagonists. Zilowa mthupi, mankhwalawa amathandizira kuchepetsa vutoli ndipo limalepheretsa calcium kulowa m'maselo.

Kutsika kwa kupanikizika sikukhudza kugunda kwa mtima. Mtengo wapakati ndi ma ruble a 350-600, kutengera mlingo.

Zizindikiro ndi contraindication

Akatswiri amawapereka kwa odwala omwe sioyenera kulandira monotherapy. Chizindikiro chachikulu cha kugwiritsa ntchito mankhwala opangidwa chifukwa cha zinthu izi ndi matenda oopsa kwa odwala omwe ali ndi:

• matenda ashuga
• hyperthyroidism
• Kuchepetsa mafupa a impso,
• atherosulinosis.

Musanagwiritse ntchito mankhwala osokoneza bongo, muyenera kudziwa zachipongwe:

• chiwindi / kulephera kwa impso,
• matenda oopsa
• Hypersensitivity yogwira zosakaniza,
• tachycardia
• bradycardia
• kukhalapo kwa stenosis mkamwa mwa msempha.

Mosamala kwambiri, amaloledwa kumwa mankhwala, kuyang'anira mosamala mlingo wokhazikitsidwa ndi adotolo, kwa odwala omwe ali ndi hyperkalemia, mitral stenosis, atavutika ndi myocardial infarction.

Mimba imapatsanso. Izi zikuchitika chifukwa cha kupezeka kwa zodabwitsazi mukukula kwa mwana wosabadwayo. Ngati mayi walandira chithandizo ndikuzindikira za pakati, phwando liyenera kuyimitsidwa nthawi yomweyo.

Sitikulimbikitsidwa kumwa mankhwala mukamayamwitsa. Akatswiri adachita kafukufuku wokhudza nyama ndipo adapeza kuti zochuluka za zinthuzo zimalowa mkaka. Pofuna kuti musawononge thanzi la mwana wakhanda, muyenera kusiya njira yochizira ndi mankhwalawa.

Mu ana, palibe chidziwitso chazotetezedwa ndi zinthu zomwe zimagwiritsidwa ntchito ndi ana ochepera zaka. Motere, mankhwala amaperekedwa kwa anthu azaka zopitilira 18.

Kutenga Lozap ndi Mowa

Odwala ambiri amakhulupirira kuti kumwa mowa sikungawavulaze panthawi yamankhwala. Koma, kumwa mowa kuyenera kuchitika pambuyo pa tsiku mutatenga mapiritsi. Pankhaniyi, odwala ayenera kudziwa kuti mphamvu ya mankhwalawa mukamamwa imawonedwa masana. Kuti muwonetsetse kuti mankhwalawa alidi ambiri, mankhwalawa amayenera kumwa moyenera. Ndiye chifukwa chake Lozap ndi mowa sizigwirizana.

Munthawi ya kukonzekera munthawi yomweyo mankhwala ndi mowa, zotsatira zawo zoyipa zimawonedwa. Malinga ndi ndemanga za odwala ena okhudzana ndi mankhwalawa, titha kuwerengetsa kuti munthawi ya kuyamwa kwa munthawi yomweyo mankhwala ndi mowa sanalandire mavuto. Pankhaniyi, anali mwayi chabe. Zitsanzo zochepa sizipereka ufulu wonena kuti kumwa mowa ndikofunikira.

Lozap ndi mankhwala osokoneza bongo. Ndiye chifukwa chake ndi chithandizo chake amachepetsa kuthamanga kwa magazi. Chodabwitsa cha mankhwalawa ndikuti iyenera kumwa kwa nthawi yayitali. Zotsatira zake zimadziwika pokhapokha ngati magawo a mankhwala ali m'magazi nthawi zonse. Kuyanjana kwa zakumwa ndi mowa sikunaphunziridwe mokwanira, kotero momwe thupi limachitikira munjira imeneyi zitha kukhala zosayembekezereka.

Mowa utalowa m'magazi, mitsempha ya magazi imayamba. Ngati pali zinthu zina zomwe zimagwira m'thupi la mankhwalawo, mowa ndiye kusokoneza kwake. Zotsatira zake, zotengera zidzafalikira msanga, ndipo mawu am'mimba amachepera. Ndi ntchito iyi, kuthamanga kwa magazi kumatha kuchepa kwambiri.

Kuphatikizika kwa Lozap ndi mowa kumatha kupezeka osati ndikuwunika kwa odwala, komanso ndi madokotala. Akatswiri akuti kugwiritsa ntchito mankhwalawa nthawi imodzi ndi mowa ndizoletsedwa.

Kuchita ndi njira zina

Ndi kuphatikiza kwa losartan ndi amlodipine omwe ali ndi mankhwala okhala ndi zinthu zambiri, zotsatira zake zitha kukhala zabwino. Zotsatira zake, kuchepa kowopsa komanso kwamphamvu kwa magazi kumajambulidwa, komwe kumapangitsa kuti wodwalayo asamasangalale. Chifukwa chake, musaphatikize nokha mankhwalawa.

Amlodipine amaletsedwa kuphatikiza ndi:

• beta-blockers (chiopsezo chowonjezeka cha zovuta za mtima Kulephera),
• zoletsa zamphamvu (zomwe zimapangitsa kuti magazi azikhala mokwanira),
• quinidine ndi amiodarone (kuchuluka kwa ionotropic).

Losartan sagwiritsidwa ntchito limodzi ndi:

• potaziyamu woletsa kukodzetsa (kungayambitse kuchuluka kwa ndende ya potaziyamu),
• fluconazole (kumawonjezera kuchuluka kwa zinthu m'magazi),
• rifampinum (imapangitsa kuti mankhwalawa asamagwire bwino ntchito).

Ngati wodwalayo ali kale kulandira chithandizo chamankhwala, adokotala ayenera kudziwitsidwa poyankhulana kaye koyamba.

Analogs ndi ndemanga za madokotala ndi odwala

Nthawi zina, pamafunika kusintha mankhwalawo. Katswiri amafunika kusankha mankhwala ofanana ndi omwe ali oyenera kwa wodwalayo. Pakati pawo, ma analogi amatha kusiyanasiyana pamtengo, komanso pamndandanda wazowonjezera.

Zoyimira m'malo kwambiri ndi:

1. Reserpine (mapiritsi, ma ruble 390-400). Kutengera reserpine. Ili ndi kuchepa kopitilira kuthamanga kwa magazi. Zili pagulu la anthu achifundo. Normalized renin katulutsidwe, kugunda kwa mtima.
2. Raunatin (ma ruble 100-110). Mapiritsiwo ali ndi gawo logwira - alkaloid wa Rauwolfia. LP imadziwika ndi katundu wa hypotensive, imasintha thupi.

Odwala ambiri omwe amagwiritsa ntchito mankhwala osokoneza bongo ndi zinthu izi amakhutira ndi zotsatirapo zake.

Akatswiri amazindikira kuti zinthuzo zimathandizana wina ndi mnzake, potero zimathandizira komanso zimathandizira. Oyenera odwala omwe ali ndi zaka zopuma.

Amlodipine ndi losartan ndi zinthu zomwe zimapanga kuphatikiza kwakukulu. Yesetsani kuchepa kwapang'onopang'ono kopanikizika popanda kuchita zoyipa mthupi.

Ntchito Lozap Plus

Pulogalamu yamakono yamapulogalamu imadziwika ndi kukhalapo kwa mankhwala atsopano a Lozap Plus. Potengera momwe zimakhalira ndi mawonekedwe ake amasulidwe, ndizofanana ndi mankhwala oyambirirawo. Mutha kusiyanitsa mwa mawonekedwe okha. Kuphatikizika kwa mankhwalawa kumaphatikiza zigawo ziwiri zazikulu - potaziyamu losartan ndi hydrochlorothiazide, zomwe zimadziwika ndi kukhalapo kwa diuretic. Izi zimathandizira pakukonzekera zochita za wina ndi mnzake, zomwe zimawonetsedwa moyenera pakuthandizira matenda oopsa.

Mankhwala amakhala ndi kukhalapo kwa okodzetsa, komwe kumapangitsa kuwonjezeka pang'ono kwa zochita za uric acid m'madzi am'magazi. Pogwiritsa ntchito mankhwalawa, kuwonjezeranso mphamvu ya renin ndi kuchepa kwa potaziyamu kumachitika. Mankhwala achikhalidwe ndi oletsedwa kugwiritsa ntchito kwa odwala omwe ali ndi hypovolemia. Contraindication pakugwiritsa ntchito mankhwalawa ndi anuria.

Posachedwa, pakuwonjezeka kwakukulu kwa anthu omwe amadwala matenda a mtima, ndipo kuwonjezereka kwa magazi kukupezekanso. Nthawi zambiri, izi pathological mikhalidwe zimawonedwa ndi zochitika zopsinjika kwambiri komanso mtundu wamoyo kwambiri.

Pofuna kuthana ndi vuto la manjenje anthu amagwiritsa ntchito njira zosiyanasiyana - kumwa mowa, kuchita panja, masewera otopetsa. Koma, munthu azikumbukira kuti kumwa zakumwa zoledzeretsa ndi kusanjanso munthawi yomweyo ndi mankhwala ndizoletsedwa. Izi ndichifukwa mowa umatha kukhumudwitsa. Panthawi ya kayendetsedwe kake, kusintha kosungidwa kwa mankhwalawa m'thupi kumawonedwa, komwe kumatha kubweretsa zotsatira zosatsimikizika. Choyipa chopweteketsa kwambiri cha chithandizo chotere ndikuchepa kwake.

Kupsinjika kwa magazi ndi chimodzi mwazofunikira kwambiri pofufuza wodwala. Anthu ambiri nthawi zambiri amakhala ndi nkhawa chifukwa cha kudumpha kwake, komwe kumabweretsa zovuta zambiri ndikusokoneza moyo wabwinobwino. Chifukwa chake, aliyense akufuna njira yothandiza kwambiri kuti athetse mavuto ake. Imodzi mwa njirazi ndi Lozap, malangizo ogwiritsira ntchito, omwe ayenera kuphunziridwa mwatsatanetsatane, komanso kuti amvetsetse momwe ayenera kutsutsidwa.

Malangizo ogwiritsira ntchito Lozap

Kwa zaka zambiri, kulimbana ndi matenda oopsa osagonjetseka?

Mkulu wa Sukulu: “Mudzadabwitsidwa momwe kumakhalira kosavuta kuchiza matenda oopsa tsiku lililonse.

Pali mitundu iwiri yamankhwala pamsika wamankhwala - Lozap (JSC Saneka Pharmaceuticals, Slovakia) ndi Lozap Plus (Zentiva LLC, Czech Republic).

Kodi pali kusiyana kotani?

"Lozap" ndi mankhwala amodzi a losartan. Losartan ndi blocker omwe amangogwira ma angiotensin II receptors.

Owerenga athu adagwiritsa ntchito bwino ReCardio kuchiza matenda oopsa. Kuwona kutchuka kwa malonda, tidaganiza zoperekera chidwi chanu.

Angiotensin II - mahomoni okhala ndi kukanikiza - kuchuluka kwa magazi - kwenikweni, opangidwa kuchokera ku angiotensin I motsogozedwa ndi enzyme ya ACE. Imayang'anira vasoconstriction, kuchuluka kwa kuphatikizira kwa sodium ions mu impso, kukondoweza kwa kupanga aldosterone ya mahomoni, ndipo ndi gawo la RAAS hormonal system, yowongolera kuthamanga kwa magazi komanso kuchuluka kwa kuzungulira kwa magazi (magazi, zamitsempha) m'thupi.

Magulu a Losartan amalimbitsa thupi onse chifukwa cha angiotensin II, kuchepetsa kukakamiza, mosasamala kanthu za dongosolo la RAAS.

Mankhwala "Lozap Plus", kuphatikiza losartan, lili ndi okodzetsa hydrochlorothiazide, thiazide diuretic ndi saluretic (kuwonjezera chimbudzi cha sodium ndi chlorine ndi impso) kanthu. Losartan imalepheretsa vasoconstriction ndikuchepetsa minofu ya mtima, ndipo hydrochlorothiazide imathamangitsa madzi owonjezera kuchokera mthupi, ndikupititsa patsogolo mphamvu ya mankhwala.

Kupanga ndi mawonekedwe a kumasulidwa

Mapiritsi amapezeka mu chipolopolo.

Kuphatikiza kwa mankhwalawa kukuwonetsedwa pagome.

• kuchuluka kosalekeza kwa kuthamanga kwa magazi pamwamba pa 140/90 mm RT. Art. mutasiyiratu zinthu zonse zoyambitsa (zosafunika matenda oopsa) mwa akulu ndi ana azaka 6,
• kukanika kwa aimpso kwa achikulire omwe ali ndi matenda oopsa ndipo amalemba mtundu wachiwiri wa shuga m'mapuloteni okhala ndi mapuloteni mu mkodzo woposa 500 mg / tsiku (mu zovuta zochizira matenda oopsa),
• Kulephera kwamtima kwa mtima kwa odwala omwe ali ndi zaka zopitilira 60, ngati ataponderezedwa ndi kutenga ACE zoletsa,
• chiwopsezo cha kugunda kwamtima ndi mikwingwirima mwa akulu omwe ali ndi matenda oopsa komanso kukulitsa kwamitsempha yamanzere yamtima, yotsimikiziridwa ndi ECG.

Kuperewera kwa mphamvu ya monotherapy ndi losartan kapena hydrochlorothiazide, kusowa kwa kuchepa kwamphamvu kwa zowonetsa. Sikugwiritsidwa ntchito ngati njira yayikulu yochepetsera kuthamanga kwa magazi.

• tsankho la munthu aliyense wosamverapo kapena aliyense mwa iwo,
• kulephera kwachidziwikire

• mimba kapena kukonzekera kwake. Losartan ali ndi tanthauzo la teratogenic ndipo amatsogolera kusokonezedwa kapena kufa kwa intrauterine kwa mwana, sikugwiritsidwa ntchito poyamwitsa,
• limodzi makonzedwe a mankhwala okhala ndi aliskiren a matenda a shuga ndi / kapena kukanika kwaimpso (kusefera kwa glomerular zosakwana 60 ml / min).

Kuphatikizanso kwa lozap, ma contraindication ena:

• tsankho kuti sulfonamides (hydrochlorothiazide - sulfonamide),
• kupatuka pa chizolowezi cha electrolyte homeostasis - hypokalemia, hypercalcemia, hyponatremia (Refractory),
• anuria (kuchepa kwa mkodzo mu chikhodzodzo),
• cholestasis (kuchepetsa kapena kufafaniza kwa bile secretion), kutsekeka kwa biliary,
• kuchuluka kwa uric acid m'magazi kapena m'mimba matenda,
• creatinine chilolezo (CC) zosakwana 30 ml / min,
• wazaka 18.

Mlingo "Lozap"

Ndi matenda oopsa, 50 mg patsiku amalembedwa piritsi limodzi, osakwanira, koma ndi kulolera bwino, mlingo umakulitsidwa mpaka 100 mg kamodzi patsiku. Kuchuluka kwake kumachitika pambuyo pa milungu 6- ya makonzedwe. Mankhwalawa amatha kuthandizidwa ndi ma diuretics. Ana a zaka 6 zakubadwa amapatsidwa mlingo umodzi wa 25 mg. Ngati munthu wamkulu akulemera zosakwana 50 makilogalamu, poyamba akhoza kupatsidwa mlingo wa 25 mg.

Odwala omwe ali ndi zovuta (AH + mtundu II shuga + mapuloteni mu mkodzo woposa 500 mg / tsiku), Lozap pamwambapa atha kuphatikizidwa ndi diuretics, blockers (calcium channels, cy- kapena β-receptors), insulin ndi mankhwala ofanana amachepetsa shuga .

Ngati kulephera kwa mtima, mankhwalawa amayamba kumwa pa 12.5 mg patsiku, sabata iliyonse akuwonjezera mlingo wa 50 mg patsiku, pokhapokha ngati umaloledwa.

Odwala ndi kuwonjezeka kwa kumanzere kwamitsempha yamtima, koyamba mlingo ndi 50 mg patsiku. Ndi kuchepa kosakwanira kwa kuthamanga kwa magazi komanso kusowa kwa zotsatira zake, ndikofunikira kuwonjezera kuchuluka kwa hydrochlorothiazide kapena kuwonjezera "Lozap" mpaka 100 mg kamodzi patsiku.

Mlingo "Lozap Plus"

Mulingo woyambira woyamba ndi 50 mg kamodzi tsiku lililonse. Ngati kuchepa kwa kuthamanga kwa magazi sikokwanira, n`zotheka kugwiritsa ntchito 100 mg kamodzi patsiku. Achire zotsatira ukufika kwambiri pambuyo 3-4 milungu kuyambira chiyambi cha makonzedwe.

Kwa odwala oopsa okalamba ndi osachepera zaka zambiri, kusintha kwa mlingo sikofunikira. Kafukufuku wokhudza kuchuluka kwa mankhwalawa kwa ana sanachitike, motero sanapatsidwe mankhwala awa. Odwala okhala ndi creatinine chilolezo (CC) owonjezera 30 ml / min, kusintha koyambirira kwa mlingo sikofunikira. Ndi CC ochepera 30, mankhwalawa satchulidwa.

Bongo

Ndi mankhwala osokoneza bongo a losartan, olemba motere:

• kutsika kwa kupanikizika pansipa magawo a thupi.
• mathamangitsidwe, kapena, kusinthasintha kwa mtima.

Ndi mankhwala osokoneza bongo a hypochlortiazide, kuchepa kwamadzi kwambiri komanso kusintha kwa zinthu zamagetsi zamagetsi kumachitika, chifukwa chotsatira akuti:

• arrhythmias, mantha,
• minofu kukokana, kukomoka, chisokonezo,
• kusanza, kusanza, ludzu.

Chifukwa chake, mankhwala ophatikiza ndi owopsa pankhaniyi. Palibe mankhwala enieni kwa losartan; samatulutsidwa ndi hemodialysis. Hypochlorothiazide imachotsedwa ndi hemodialysis, koma kukula kwake sikunakhazikitsidwe.

Mankhwala osokoneza bongo, muyenera kutsuka m'mimba mwachangu, kumwa makala ogwiritsidwa ndi piritsi limodzi la 10 makilogalamu 10 alionse a kulemera kwa thupi. Kuphatikiza apo, mankhwalawa ndiwowoneka bwino, umalimbana ndikuwonetsa zisonyezo zovomerezeka, kubwezeretsanso kuchuluka kwa madzi ndikubwezeretsani mulingo wamagetsi.

Zotsatira zoyipa za losartan:

• kuwala, chizungulire (1% kapena kuposa),
• mutu, kusokonezeka kwa tulo, kapena, kugona, pafupifupi 1%),
• minofu kukokana, nthawi zambiri ng'ombe (1% kapena kuposa),
• angina pectoris, tachycardia (pafupifupi 1%),
• hypotension, kuphatikizapo orthostatic,
• kupweteka mu peritoneum, dyspepsia, kudzimbidwa (1%),
• kutupa kwa mucosa wammphuno (kupitirira 1%), chifuwa,
• kufooka wamba
• kufunikira kwamphamvu,

• zimachitikira, kuphatikizapo edema wa Quincke,
• kusintha kwa kapangidwe ka magazi (kuchepa magazi, hemolysis, thrombocytopenia),
• kuchepa kapena kusowa kwa chakudya,
• crystallization wa urasis mu thupi (gout),
• kusokoneza chiwindi,
• kuchepa kugonana kuyendetsa, kusabala.

Zotsatira zoyipa za hydrochlorothiazide (zomwe zimawonetsedwa kwambiri.

• hematological pathologies (agranulocytosis, aplastic ndi hemolytic anemia, leukopenia, purpura, thrombocytopenia, neutropenia),
• chifuwa, kuphatikiza anaphylactic mantha,
• metabolism ndi electrolyte kusowa bwino (kuchuluka kwa shuga ndi / kapena urea ndi / kapena lipids m'magazi, kuchepa kwa magnesium kapena sodium ion, owonjezera calcium calcium),
• kugona, mutu,
• kuwonongeka kwamawonekedwe
• vasculitis (zotupa zam'mimba),
• kupuma
• kukanika kwa tiziwalo tating'onoting'ono, kukhumudwa kwa m'mimba,

• Hypochloremic alkalosis (kuchepa kwa anyezi wa chlorine kumalipiriridwa ndi anyezi wa bicarbonate),
• intrahepatic cholestasis, cholecystitis, kapamba,
• kuwoneka kwa shuga mumkodzo, nephritis yapakati, kukanika kwa impso,
• onjezerani khungu
• kusokonekera kwa erectile, kusabala,
• kukhumudwa

Mndandanda wazotsatira zoyipa ndi zabwino kwambiri. Dziwani kuti kuthekera kwa kakulidwe kake sikawonjezereka 1% ndipo ambiri aiwo amasintha pomwe mankhwalawo amachotsedwa. Komabe, chithandizo chamankhwala a losartan kapena losartan omwe ali ndi hydrochlorothiazide ayenera kuyang'aniridwa ndi achipatala, ngati mukumva kuti mukusowa, muyenera kufunsa dokotala, osakayika.

Mogwirizana ndi "Lozap" ndi mankhwala ena:

• "Rifampicin", "Fluconazole", mankhwala osagwiritsa ntchito mankhwala ochepetsa mphamvu ya kutupa omwe amachepetsa mphamvu ya antihypertensive a losartan,
• losartan imathandizanso kukakamiza-kuchepetsa mphamvu ya okodzetsa, ma adrenergic blocking othandizira, angiotensin-kutembenuza enzyme inhibitors (Captopril, Enalapril),
• Ndi munthawi yomweyo makonzedwe a potaziyamu, potaziyamu wothandiza okodzetsa, hyperkalemia ikhoza kukhala.

Mukamamwa "Lozap Plus" chifukwa cha hydrochlorothiazide, mankhwala otsatirawa amawonjezeredwa pamankhwala omwe atchulidwa:

• barbiturates, narcotic painkiller, ethyl mowa - kumawonjezera mwayi ndi zovuta za hypotension ya orthostatic (kusintha kwakuthwa kwa thupi - kupepuka, chizungulire,
• Hypoglycemic mankhwala, insulin - angafune kusintha kwa mlingo,
• Mankhwala onse a antihypertensive amalimbikitsa onse,
• colestyramine - umalepheretsa kuyamwa kwa mankhwala okodzetsa,
• corticosteroids, adrenocorticotropic timadzi - kumaonjezera kutulutsa kwa ma elekitirodi, makamaka potaziyamu,
• opuma minofu - mwina kuwonjezera zochita zawo,
• okodzetsa - madzi am'madzi (kukonzekera kwa mchere wa lithiamu) kungayambitse kuledzera kwa lithiamu,
• Mankhwala osapweteka a antiidal amachepetsa mphamvu ya hypotensive, komanso amachepetsa kupukusika kwa sodium mu mkodzo.

Opanga osiyanasiyana amapanga mankhwala ambiri okhala ndi mawonekedwe omwewo, okhawo omwe amapezeka ndi omwe amatha kusiyana. Pansipa pali ena a iwo:

• "Blocktran", "Brozaar", "Vazotens", "Lorista", "Lortazan-Richter", "Lakea" - chithunzi cha "Lozap",
• "Blocktran GT", "Vazotens N", "Gizaar", "Lozarel kuphatikiza", "Lorista N", "Lortazan-N Richter" ndi fanizo la "Lozap kuphatikiza".

Odwala amayankha bwino kwambiri ngati "Lozap" sikhala ndi malire pazoyenera, "Lozap kuphatikiza" ndiwongolera vutoli. Madandaulo okhudzana ndi zovuta ndizochepa.

Lozap ndi matenda oopsa: malamulo ogwiritsa ntchito mankhwalawa

Mankhwala a Lozap ndi m'badwo watsopano wa mankhwala a antihypertensive. Matenda oopsa a magazi - kuthamanga kwa magazi, pomwe 3 pazochitika zonse ndi 140/90 mm Hg. Art. zidzakulitsidwa.

Kuopsa kwa matendawa kumachitika chifukwa chakuti nthawi zambiri pamakhala zopanda zizindikiro zakunja, koma pang'onopang'ono kuthinikizidwa kumakhala chinthu chowonjezera makoma amitsempha yamagazi. ndiye chotengera chimang'ambika ndipo nthawi zambiri chimayambitsa kugunda kwa mtima kapena stroko.

Mankhwalawa amaperekedwa kumsika wogulitsa mankhwala ngati mawonekedwe a mapiritsi pafupi ndi oyera ku milligram pa 12,5, 50 ndi 100. Mankhwala othandizira omwe amachepetsa kukana kwamitsempha yamagazi, kuthamanga kwa magazi, adrenaline ndi zina zomwe zimapangitsa zotsatira zake.

Wothandizika kwambiri angayesedwe ndi ma receptor suppressants of the causative agent of arterial hypertension - angiotensin II. Amapezeka ndi gawo lalikulu lamaluso - losartanine. Potaziyamu losartan amagwira ntchito ngati yogwira, magnesium stearate, komanso mannitol, etc. ndi othandiza.

Zolemba za mankhwala

Lozap ili ndi gawo lodziwikiratu - limayenda bwino komanso mwamakhalidwe limachepetsa kuthinana kwamtundu wanthawi zonse, imalepheretsa stroko, kugunda kwa mtima ndi zina. Mothandizidwa ndi mankhwalawa, kuchulukitsa kwa moyo wa odwala omwe ali ndi matenda oopsa kungatheke. Kwa mankhwala osowa, malangizo omwe angagwiritsidwe ntchito amaphatikizapo zonse zomwe zikuwonetsa ndikuwonetsa ma contraindication ofunikiranso, omwe amafunikanso kwambiri kuti adziwe ndikutsatira.

Chofunikira kwambiri cha antihypertensive mutatha kutenga zinthu ziwoneka pambuyo pa maola 6 ndipo pang'onopang'ono kuchepa masana. Zotsatira zabwino kwambiri zochizira zimachitika pambuyo povomerezeka kwa milungu itatu. The bioavailability wa mankhwalawa ndi ochepa, zomwe zikusonyeza kuti kudya sikungakhale ndi vuto lililonse.

Kuphatikiza apo, mothandizidwa ndi mankhwalawa ndizotheka kukwaniritsa kuchepa kwamapuloteni ena apadera omwe amatenga nawo mbali pa njira za immunological. Kuchuluka kwa mapuloteni mumkodzo, komanso mapuloteni amtundu wa plasma m'magazi, kumachepa.

Zisonyezo za kumwa mankhwalawa

Pali zizindikiro ndi matenda angapo omwe amaphatikizapo malangizo ogwiritsira ntchito ngati mankhwala ofanana a antihypertensive adalembedwa. Chifukwa cha chithandizo chamankhwala, lapis imakhala ndi izi:

• Arterial hypertension (matenda oopsa) - matenda wamba a mtundu wosakhazikika, kuchititsa kuchuluka kwa magazi. Itha kutha kuyenda limodzi ndi zizindikiro zapadera, kupatulapo khungu komanso chizungulire, koma ngati chithandizo chosagwiritsidwa ntchito nthawi zambiri chimayambitsa stroko, kugunda kwamtima, mavuto ammaso komanso zovuta zina.
• Kulephera kwamtima kosalekeza - Lozap amalembedwa limodzi ndi mankhwala owonjezera pomwe sagwira ntchito mokwanira kapena munthu salekerera angiotensin-converting enzyme inhibitors. Matendawa amawonetsedwa ndi zikhalidwe - kufupika, kutopa kwambiri, kutupa, kutaya mphamvu, ndi zina zambiri).
• Proteinuria, komanso hypercreatininemia, limodzi ndi matenda a matenda ashuga nephropathy - kuwonongeka kwakanthawi, mavuto a tubules ndi zina za impso mu shuga mellitus yachiwiri. Mavutowa atha kukhala limodzi ndi matenda oopsa.

Kuphatikiza pazinthu izi, malangizo a mankhwala osokoneza bongo ali ndi chizindikiro china chogwiritsira ntchito - ndi kuchepetsa kuwopsa kwa matenda a mtima, kuphatikizapo mikwingwirima. Amachepetsa chiopsezo cha kufa kwa odwala omwe ali ndi vuto lamanzere lamitsempha yamagazi. Chiwopsezo cha kufa kwa omwe akudwala matenda oopsa amachepetsa.

Owerenga athu adagwiritsa ntchito bwino ReCardio kuchiza matenda oopsa. Kuwona kutchuka kwa malonda, tidaganiza zoperekera chidwi chanu.

Zokhudza ubale komanso mtheradi

Lozap mu malangizo ogwiritsa ntchito ali ndi zotsutsana mwamtheradi komanso zolakwika. Mtheradi - kuchita kwathunthu ndikulankhula kuti mankhwalawa sayenera kugwiritsidwa ntchito pamaso pa zotsutsana mwanjira iliyonse. Mtheradi contraindication ntchito mankhwalawa:

1. Kusavulala komanso kugwira bwino ntchito kwa lapz mpaka zaka 18 sizinakhazikitsidwe, popeza mu m'badwo uno, makamaka, palibe umboni wogwiritsa ntchito lapz,
2. Kuwonongeka kwambiri kwa chiwindi - panalibe mayeso azithandizo zamankhwala kwa odwala omwe ali ndi mtengo wofanana ndi kuchuluka kwa Child-Pugh pamtunda wa 9 point,
3. Mimba komanso kuyamwa
4. Pankhani ya matenda a shuga, komanso kulephera kwa aimpso, magazi akakhala kuti sanadutse pafupifupi mamililita 60 mphindi imodzi, simungathe kuphatikiza lorap ndi aliskiren,
5. Munthu payekha amawonjezera chidwi cha zigawo zina za mankhwala.

Zoyipirana zomwe zimagwera pagulu ndizovomerezeka zingapo pomwe chida sichikulimbikitsidwa, koma lingaliro lomaliza limapangidwa ndi adokotala.Nthawi zambiri, kubetana kwapadera kumakhala kwakanthawi ndipo wodwalayo akangomaliza kuphwanya kofananako, amatha kutenga patis, moyang'aniridwa ndi dokotala. Mtundu wachibale wamalangizo ophatikizira uphatikizira izi:

1. Arterial hypotension - pomwe kuthamanga kwa magazi kutsika mpaka pakuwonekera kwa munthu. Kuthamanga kwa magazi sikulimbikitsidwa kuti kuchepetsedwe kosachepera malire oyenera, omwe ndi 110/70 mm Hg, pomwe ndi Hypotension chizindikiro ichi chimatsika ndi 15-20%.
2. Kulephera kwa mtima, komwe kumayendetsedwa ndi kulephera kwambiri kwa impso.
3. Hyperkalemia ndi matenda omwe amachititsa kuti azikhala ndi potaziyamu yambiri m'magazi.

1. Matenda a mtima.
2. Kulephera kwamtima kwambiri mu mawonekedwe a 4 othandizira.
3. Matenda a Cerebrovascular - gulu lalikulu la matenda okhudza masoka amanjenje, ubongo, omwe amayamba ndi matenda a m'mitsempha.
4. Kukhala wa mpikisano wakuda,
5. Zaka kuyambira zaka 75 ndi ena.

Njira zowonetsera, kuyamwa ndi chimbudzi

Angiotensin II ndi vasoconsitricator wamphamvu komanso hormone yofunikira yogwirizana ndi renin-angiotensin-aldosterone system. Ichi ndiye cholumikizira chachikulu cha kuphatikizana kwa matenda m'thupi.

Chomwe chimapangidwira mu mawonekedwe osankha chimatha kulumikizana ndi ma receptors a AT omwe amapezeka m'matumbo a adrenal, komanso zotengera zosalala za minofu ndi ena ambiri. Kuphatikiza apo, ndizolimbikitsa zomwe zimapangitsa kuti maselo a minofu yosalala azikhala osalala.

Atatha kumwa mapiritsiwo, amamwetsedwa bwino, ndipo chinthu chomwe chimagwira ntchito chimakhala ndi mndandanda wathunthu wa metabolic mu chiwindi ndikupanga metabolite yogwira. Pafupifupi 14% ya mankhwala omwe amalumikizidwa pafupifupi osinthika amasinthidwa kukhala metabolite yogwira ntchito, mosasamala kanthu za njira yolowera kapena yamkati yoyendetsera.

Lozap satha kudutsa zotchinga zachilengedwe kuteteza ubongo. The bioavailability wa mankhwala ndi wotsika, zomwe zikutanthauza kuti kudya sikungakhale ndi vuto lililonse. Mukatha kumwa lapoz pafupifupi 4% ya mankhwalawa adzachotsedwanso chimodzimodzi pogwiritsa ntchito impso. Pafupifupi 6% imachotsedwa impso ndi mawonekedwe a metabolite yogwira.

Zambiri za pharmacokinetics zokhudzana ndi atypicality ya gulu la odwala ndi izi:

• Odwala okalamba - kwa amuna, kuchuluka kwa mankhwalawa, komanso metabolite yogwira, sizosiyana kwambiri malinga ndi zizindikiro, monga kwa amuna achichepere odwala.
• Kugonana kwa wamwamuna ndi wamkazi - kunali kuwonjezeka kawiri kuchuluka kwa losartan m'madzi am'magazi a odwala, koma kusiyana komveka kotereku sikumakhala ndi zotsatira zapadera zamankhwala.
• Anthu omwe ali ndi vuto la chiwindi - anthu omwe ali ndi vuto lochepa la chiwindi amakhala ndi kuchuluka kwa nthawi 5 komanso pafupifupi kawiri kuposa maphunziro abwino,
• Odwala omwe ali ndi vuto laimpso - sipadzakhala kusiyana kwakukulu pakumenyedwa kwa losartan.

Mtengo ndi fanizo la mankhwala

Ku lapoz, mtengo umasiyanasiyana kutengera wopanga, komanso kuchuluka kwa mapiritsi omwe ali mgululi komanso kuchuluka kwa mamiligilamu. Czech lozap (Zentiva) imakhala ndi ma ruble 300-350. 30 ma PC. ndi ma ruble 750-800. pa paketi yonse ya ma 90 ma PC. Pali mitundu yambiri yamapangidwe aku Russia ndi akunja, kuphatikiza izi:

• Lorista
• Losartan
• Nyanja
• Losartan Richter (Poland),
• Blocktran ndi ena ambiri.

Lorista ndi mankhwala opatsidwa kuchiza matenda a mtima osalephera komanso zisonyezo zina zomwe zimawonetsedwa pamankhwala amisala. Lakea ndi mankhwala osokoneza bongo othandizira matenda oopsa, komanso kutsekereza kukula kwa impso.

Losartan - kuchepetsa chiopsezo cha stroke, kuteteza impso mwa odwala omwe ali ndi matenda ashuga. Amapangidwa ku Makedonia (Alkaloid JSC), Russia (Ozone LLC, Vertex CJSC, Canonpharma, etc.), Israel (Teva). 30 mapiritsi mu paketi yomwe mungagule kuchokera ku ruble 100 mpaka 300.

Blocktran ndi mankhwala omwe amaphatikizidwa ndi mankhwala othandizira kulephera kwamtima mu mawonekedwe osakhazikika. Amapangidwa ndi makampani opanga mankhwala ku Russia Leksredstva ndi Pharmstandard. Muzipatala mutha kugulidwa pamtengo wokwana ma ruble a 150-300. kutengera wopanga ndi kuchuluka kwa mg mu piritsi limodzi (12.5 kapena 50 mg).

Kuchita ndi mankhwala ena

Monga momwe zimakhalira nthawi zambiri, kugwiritsa ntchito mankhwala osokoneza bongo ndi ena kungayambitse kuchepa kapena kuwonjezeka, komanso mavuto ena. Ngati mumwa mapiritsi limodzi ndi ena a beta-radar, zotsatira zake zimakhala zotsiriza.

Kuphatikiza ndi diuretics, zotsatira za mankhwalawa ndizowonjezera. Kugwiritsa ntchito mankhwala osokoneza bongo monga digoxin, warfarin kapena cimetidine kulibe atypical. Kugwiritsika ntchito kwa lozap kuphatikiza ndi okodzetsa mawonekedwe a potaziyamu kungayambitse kukula kwa hyperkalemia.

Kumwa mankhwalawa nthawi yoyamwitsa kapena pakati

Sitikulimbikitsidwa kuti mutengeko mu nthawi yoyamba kukhala ndi pakati, ndipo mukulumikizidwa wachiwiri ndi wachitatu. Zambiri pamaziko a maphunziro okhudzana ndi mapiritsi a mapiritsi munthawi yoyamba kubereka ndi zotsutsana, koma chiwopsezo kwa mwana wosabadwa sichimatulutsidwa kwathunthu. Ngati ndi kotheka, dokotala atha kukuwonetserani kupitiliza kwa chithandizo choyenera, komabe, ngati wodwalayo ali pachiwopsezo chokhala ndi pakati, ayenera kusamutsidwira ku mtundu wina wamankhwala.

Ngati panali phwando la lozap chifukwa cha zifukwa zina mu 2nd trimester, kuyezetsa kwa fetus kwa mwana wosabadwayo kuyenera kuwunika momwe impso ikuyendera, komanso momwe mafupa aku cranal alili. Amayi omwe amamwa lozapakati pa nthawi yobereka amatha kukhala ndi ana omwe ali pachiwopsezo chachikulu cha kukhala ndi hypotension yotsatira komanso kuyang'aniridwa mosamala kwachipatala kumafunikira.