Kuyimitsidwa kwa ana Amoxiclav 125 mg: malangizo ogwiritsira ntchito

Mapiritsi okhala ndi mafilimu 500 mg / 125 mg, 875 mg / 125 mg

Piritsi imodzi yokutidwa ndi kanema ili

ntchito: amoxicillin (monga amoxicillin trihydrate) 500 mg ndi clavulanic acid (monga potaziyamu clavulanate) 125 mg (kwa 500 mg / 125 mg) kapena amoxicillin (monga amoxicillin trihydrate) 875 mg ndi clavulanic acid (monga potaziyamu clavulanate) 125 mg (Mlingo wa 875 mg / 125 mg).

zokopa: colloidal silicon dioxide, crospovidone anhydrous, sodium carboxymethyl cellulose, magnesium stearate, ya cellulose yophimba ya microcrystalline.

filimu co kuyanika: hydroxypropyl cellulose, ethyl cellulose, polysorbate, triethyl citrate, titanium dioxide (E 171), talc.

Mapiritsiwa adakutidwa ndi utoto wa filimu yoyera kapena yoyera, oblong, yokhala ndi bevel, wolembedwa "875/125" ndi chikhomo mbali imodzi, ndipo adalemba ndi "AMS" mbali inayo (pamtundu wa 875 mg / 125 mg).

Fgulu laacacotherapeutic

Mankhwala a antibacterial pakugwiritsa ntchito kwadongosolo. Beta-lactam antibacterial mankhwala - Penicillins. Ma penicillin osakanikirana ndi beta-lactamase zoletsa. Clavulanic acid + amoxicillin.

ATX Code J01CR02

Mankhwala

Pharmacokinetics

Amoxicillin ndi clavulanic acid amasungunuka kwathunthu mu madzi amchere pazofunikira za thupi pH. Zonsezi ndizoyamwa bwino pakamwa. Mulingo woyenera kumwa amoxicillin / clavulanic acid mukadzayamba kudya. Pambuyo pakamwa, bioavailability wa amoxicillin ndi clavulanic acid pafupifupi 70%. Mphamvu ya kuchuluka kwa mankhwalawa mu plasma ya zigawo zonse ziwiri ndi zofanana. Pazambiri za seramu ndizodziwikiratu zimafikira ola limodzi pambuyo pa kukhazikitsa.

Serum imags ya amoxicillin ndi clavulanic acid akamatenga kuphatikiza kwa amoxicillin / clavulanic acid akukonzekera ali ofanana ndi omwe amawerengedwa pakamwa pokhapokha ngati gawo limodzi la amoxicillin ndi clavulanic acid.

Pafupifupi 25% ya kuchuluka kwathunthu kwa clavulanic acid ndi 18% ya amoxicillin amamangiriza mapuloteni a plasma. Kuchuluka kwa magawa pakamwa pakumwa mankhwala pafupifupi 0.3-0.4 l / kg wa amoxicillin ndi 0,2 l / kg wa clavulanic acid.

Pambuyo pokonzanso mtsempha wamagazi, onse amoxicillin ndi clavulanic acid adapezeka mu chikhodzodzo, mafinya am'mimbamo, khungu, mafuta, minofu yamatumbo, zotumphukira ndi zotumphukira, bile ndi mafinya. Amoxicillin amalowa bwino mu madzi a cerebrospinal.

Amoxicillin ndi clavulanic acid amawoloka placental zotchinga. Zinthu zonsezi zimadutsanso mkaka wa m'mawere.

Amoxicillin amachotsekedwa pang'ono mu mkodzo wofanana ndi penicillic acid wofanana ndi 10-25% ya mlingo woyamba. Clavulanic acid imapangidwa m'thupi ndi kuponyera mkodzo ndi ndowe, komanso mpweya wa mpweya wothira mpweya.

Kuchulukitsa kwapakati theka la moyo wa amoxicillin / clavulanic acid ndi pafupifupi ola limodzi, ndipo kuvomerezeka kokwanira pafupifupi 25 l / h. Pafupifupi 60-70% ya amoxicillin ndi 40-65% ya clavulanic acid amachotsedwa mu mkodzo mkati mwa maola 6 atatha kumwa kamodzi pa mapiritsi a amoxicillin / clavulanic acid. Pa maphunziro osiyanasiyana, zidapezeka kuti 50-85% ya amoxicillin ndi 27-60% ya clavulanic acid amachotsedwa mkodzo mkati mwa maola 24. Kuchuluka kwacrosulanic acid kumachotsedwa pakatha maola 2 mutatha ntchito.

Kugwiritsa ntchito pamodzi kwa phenenecid kumachepetsa kutulutsidwa kwa amoxicillin, koma mankhwalawa samakhudza kutuluka kwa clavulanic acid kudzera mu impso.

Hafu ya moyo wa amoxicillin imakhala yofanana mwa ana a zaka zitatu mpaka ziwiri, komanso mwa ana achikulire ndi akulu. Popereka mankhwala kwa ana aang'ono kwambiri (kuphatikiza ana akhanda) m'milungu yoyamba ya moyo, mankhwalawa sayenera kuperekedwa kawiri patsiku, omwe amalumikizidwa ndi kusakhazikika kwa njira ya impso kwa ana. Chifukwa chakuti odwala okalamba amatha kuvutika ndi vuto la impso, Amoxiclav 2X iyenera kugwiritsidwa ntchito mosamala m'gululi la odwala, koma ntchito yaimpso iyenera kuyang'aniridwa ngati kuli koyenera.

Chilolezo chonse cha amoxicillin / clavulanic acid m'madzi am'magazi amachepetsa mwachindunji kuchepa kwa impso. Kuchepa kwa chilolezo cha amoxicillin kumanenedweratu poyerekeza ndi clavulanic acid, chifukwa kuchuluka kwa amoxicillin kumathandizidwa kudzera mu impso. Chifukwa chake, popereka mankhwala kwa odwala omwe amalephera aimpso, kusintha kwa mankhwalawa ndikofunikira kuti muchepetse kuchuluka kwa amoxicillin ndikukhalabe wofunikira clavulanic acid.

Popereka mankhwala kwa odwala omwe ali ndi vuto la chiwindi, muyenera kusamala posankha mlingo ndikuwonetsetsa ntchito ya chiwindi.

Mankhwala

Amoxicillin ndi mankhwala opanga ma cell kuchokera ku penicillin gulu (beta-lactam antiotic) lomwe limalepheretsa ma enzyme amodzi kapena angapo (omwe nthawi zambiri amatchedwa ma penicillin-binding protein) omwe amaphatikizidwa ndi biosynthesis ya peptidoglycan, yomwe ndi gawo lofunikira kwambiri mwa khoma la bakiteriya. Kuletsa kwa peptidoglycan synthesis kumayambitsa kufooka kwa khungu la cell, nthawi zambiri kumatsatiridwa ndi lysis l cell ndi cell cell.

Amoxicillin amawonongeka ndi beta-lactamases opangidwa ndi mabakiteriya osagwira, chifukwa chake zochitika za amoxicillin zokhazokha sizimaphatikizapo tizilombo tating'onoting'ono timene timatulutsa ma enzymes amenewa.

Clavulanic acid ndi beta-lactam mwapangidwe kogwirizana ndi penicillin. Imalepheretsa ma beta-lactamase, potero kuletsa kuyamwa kwa amoxicillin, ndikukulitsa zochitika zake. Clavulanic acid yokha ilibe mphamvu yokhudza antibacterial.

Kuchulukitsa nthawi yopitilira muyeso wosachepera (T> IPC) imawerengedwa kuti ndiyo yofunika kwambiri pakuwonetsa mphamvu ya amoxicillin.

Njira ziwiri zomwe zingalimbane ndi amoxicillin ndi clavulanic acid ndi:

inactivation ndi bacteria beta-lactamases omwe saponderezedwa ndi clavulanic acid, kuphatikiza makalasi B, C ndi D.

kusintha kwa mapuloteni omangira penicillin, omwe amachepetsa kuyanjana kwa antibacterial wothandizila ku pathogen yomwe akufuna.

Kusakhudzidwa kwa mabakiteriya kapena njira ya pampu ya efflux (kayendedwe ka zinthu) kumatha kuyambitsa kapena kupitiliza kulimbana ndi mabakiteriya, makamaka mabakiteriya osavomerezeka.

Miyezo yokhazikika ya MIC ya amoxicillin / clavulanic acid ndizomwe zimatsimikiziridwa ndi Komiti Yaku Europe Yoyesa Antimicrobial Sensitivity (EUCAST).

Njira yamachitidwe

Amoxicillin ndi mankhwala osokoneza bongo owoneka bwino omwe ali ndi ntchito yolimbana ndi ma gram ambiri komanso gram alibe tizilombo. Nthawi yomweyo, amoxicillin amatha kuwonongedwa ndi beta-lactamases, chifukwa chake ntchito yokhala ndi amoxicillin sinafikira tizilombo tomwe timatulutsa timadzi tambiri.

Clavulanic acid, beta-lactamase inhibitor yokhudzana ndi penicillin, amatha kuyambitsa mitundu yambiri ya beta-lactamases yomwe imapezeka mu penicillin ndi cephalosporin zosagwira tizilombo. Clavulanic acid imakhala ndi mphamvu yokwanira yolimbana ndi plasmid beta-lactamases, yomwe nthawi zambiri imayambitsa kukokana kwa bakiteriya, ndipo siigwira ntchito motsutsana ndi mtundu I chromosome beta-lactamases, womwe suletsedwa ndi clavulanic acid.

Kupezeka kwa clavulanic acid pakukonzekera kumateteza amoxicillin kuti asawonongeke ndi ma enzymes - beta-lactamases, omwe amalola kukulitsa mawonekedwe a antibacterial a amoxicillin.

Amoxiclav ali ndi antibacterial zochita zotsatirazi tizilombo:

• Ma gram-anaerobes (Staphylococcus aureus, pneumococcus, pyogenic streptococcus, mitundu ina ya staphylococcus aureus ndi streptococcus, clostridia, peptococcus),
• Gram-negative anaerobes (mabakiteriya a Kolya, mabakiteriya amtundu wa Enterobacter, Klebsiella, Moraxella catarilis, Bordetella, Salmonella, Shigella, Vibrio cholera).

Chifukwa chakuti mitundu ingapo ya mabakiteriya omwe ali pamwambapa amatulutsa beta-lactamase, izi zimapangitsa kuti asamve chidwi ndi Amoxicillin monotherapy.

Pharmacokinetics

Zinthu zonse ziwiri zomwe zimagwira ntchito ndizoyamwa bwino, mosasamala kanthu za chakudya. Kuchuluka kwa plasma ndende kumafika ola limodzi mutangomwa mankhwalawa (Cmax ya amoxicillin - 3-12 μg / ml, Cmax ya clavulanic acid - 2 μg / ml.

Zigawo za Amoxiclav zimagawidwa bwino m'misempha ya cell, parietal, synovial, bronchial secretions, impso zamkati, malovu, komanso matupi amthupi (m'mapapu, matsempha a palatine, khutu lapakati, thumba losunga mazira, chiberekero, chiwindi, ndulu ya prostate, minofu ya ndulu, chikhodzodzo cha ndulu. ) Mankhwalawa sangathe kulowa mu magazi otchinga magazi (ndimankhwala osapsa). Imalowa mkati mwa chotchinga, mumayang'anitsitsa kutsitsimuka kwa mkaka wa m'mawere. Amamangirira bwino mapuloteni a plasma, amoxicillin trihydrate pang'ono amawola, clavulanic acid - kwathunthu.

Mankhwalawa amachotseredwa ndi impso pafupifupi osasinthika. Zochepa zimatulutsidwa ndi mapapu komanso matumbo. Hafu ya moyo ndi maola 1-1,5.

Amoxicillin amachotseredwa ndi impso pafupifupi osasinthika ndi kubisala kwa tubular ndi kusefera kwa glomerular. Zing'onozing'ono zimatha kupukusidwa kudzera m'matumbo ndi m'mapapu. T1 / 2 ya amoxicillin ndi clavulanic acid ndi maola 1-1,5. Kulephera kwakukulu kwa aimpso, kumawonjezera amoxicillin mpaka maola 7.5, chifukwa cha clavulanic acid - mpaka maola 4.5. Zonsezi zimachotsedwa pa hemodialysis.

Zizindikiro zogwiritsidwa ntchito

Amoxiclav ndimankhwala othana ndi bakiteriya, amawonetsedwa pochiza matenda opatsirana omwe amayamba chifukwa cha mabakiteriya omwe amakhudzidwa ndi penicillin ndi analogenes:

• matenda a chapamwamba kupuma thirakiti ndi ENT ziwalo (pachimake ndi matenda sinusitis, pachimake ndi matenda otitis TV, pharyngeal abscess, tonsillitis, pharyngitis),
• m'munsi kupuma thirakiti matenda (pachimake bronchitis ndi bakiteriya wamphamvu, matenda a bronchitis, chibayo),
• matenda a kwamkodzo thirakiti (mwachitsanzo, cystitis, urethritis, pyelonephritis),
• matenda ku matenda azachipazi,
• matenda a pakhungu ndi minofu yofewa, kuphatikiza kulumidwa kwanyama ndi anthu,
• matenda a mafupa ndi osakanikirana,
• matenda am'mimba thirakiti (cholecystitis, cholangitis),
• matenda odontogenic.

Mlingo ndi makonzedwe

Mkati. Mlingo wa mankhwalawa umayikidwa payekha kutengera zaka, kulemera kwa thupi, ntchito ya impso ya wodwalayo komanso kuopsa kwa matendawa.

Mlingo watsiku ndi tsiku wa kuyimitsidwa ndi 125 mg + 31.25 mg (kuti muthandizire dosing yoyenera, supuni ya 5 ml yomaliza ndi mulingo wa 0,5 ml kapena supuni ya 5 ml ya milingo yokhala ndi zikwangwani zojambulidwa m'milomo ya 2,5 ml yaikidwe padera lililonse ndi 5 ml).

Zithunzi za 3D

Kufotokozera za mtundu wa kipimo

Mapiritsi 250 + 125 mg: yoyera kapena pafupifupi yoyera, yotsika, ya octagonal, ya biconvex, yokutira filimu, yokhala ndi "250/125" mbali imodzi ndi "AMC" mbali inayo.

500 + 125 mg mapiritsi: zoyera kapena pafupifupi zoyera, chowulungika, biconvex, wokutidwa ndi filimu.

Mapiritsi 875 + 125 mg: yoyera kapena pafupifupi yoyera, yofupika, ya biconvex, yokhala ndi makanema, yopezeka ndi zikwangwani ndi kutanthauza "875" ndi "125" mbali ina ndi "AMC" mbali inayo.

Onani pa kink: misa yachikasu.

Mphamvu yakuyimitsidwa pakamwa: ufa kuchokera kuzoyera mpaka zoyera zachikasu. Kuyimitsidwa koyimitsidwa ndikuyimitsidwa kopusa kuchokera pafupifupi koyera mpaka chikasu.

Ufa pakukonzekera njira yothetsera utsogoleri wa iv: kuyambira oyera mpaka oyera achikasu.

Mapiritsi omwaza: oblong, octagonal, wachikasu wopepuka komanso wowerengeka wa bulauni, wokhala ndi fungo labwino.

Mankhwala

Amoxiclav ® ndi kuphatikiza kwa amoxicillin ndi clavulanic acid.

Amoxicillin ndi semisynthetic penicillin (beta-lactam antibiotic) yomwe imalepheretsa ma enzyme amodzi kapena angapo (omwe nthawi zambiri amatchedwa ma penicillin-binding protein, PSB) mu biosynthesis ya peptidoglycan, womwe ndi gawo lofunikira kwambiri la khoma la bakiteriya. Kuletsa kwa peptidoglycan kaphatikizidwe kumabweretsa kuchepa kwa mphamvu ya khoma, komwe nthawi zambiri kumayambitsa lysis ndi kufa kwa maselo a microorganism.

Amoxicillin amawonongeka chifukwa cha beta-lactamases yomwe imapangidwa ndi mabakiteriya osagwira, kotero chiwonetsero cha zochita za amoxicillin sichimaphatikizapo tizilombo tating'onoting'ono timene timatulutsa ma enzyme.

Clavulanic acid ndi beta-lactam mwapangidwe kogwirizana ndi penicillin. Imalepheretsa ma beta-lactamase ena, potero kuletsa kuyamwa kwa amoxicillin ndikukulitsa mawonekedwe ake a zochitika, kuphatikiza mabakiteriya omwe nthawi zambiri samagwirizana ndi amoxicillin, komanso ma penicillin ena ndi cephalosporins. Clavulanic acid yokha ilibe mphamvu yokhudza antibacterial.

Amoxiclav ® imakhala ndi bactericidal mu vivo Zamoyo zotsatirazi:

- zoyipa za gramu - Staphylococcus aureus *, Streptococcus pneumoniae, Streptococcus pyogene,

- gram yoyipa yotsatsira - Enterobacter spp. **, Escherichia coli *, Haemophilus influenzae *mitundu yamtundu Klebsiella *, Moraxella catarrhalis * (Branhamella catarrhalis).

Amoxiclav ® imakhala ndi bactericidal mu vitro pazinthu zotsatirazi (komabe, kufunikira kwamankhwala sikumadziwikabe):

- zoyipa za gramu - Bacillis anthracis *mitundu yamtundu Corynebacterium, Enterococcus faecalis *, Enterococcus faecium *, Listeria monocytogene, Nocardia asteroidescoagulase-negative staphylococci * (kuphatikiza Staphylococcus epidermidis), Streptococcus agalactiae, mitundu ina yamtundu Streptococcus, Streptococcus viridans,

- anaerobes a gramu - mitundu ya mtundu Clostridiummitundu yamtundu Peptococcusmitundu yamtundu Peptostreptococcus,

- gram yoyipa yotsatsira - Bordetella pertussismitundu yamtundu Brucella, Gardnerella vaginalis, Helicobacter pylorimitundu yamtundu Legionella, Neisseria gonorrhoeae *, Neisseria meningitidis *, Pasteurella multocida, Proteus mirabilis *, Proteus vulgaris *mitundu yamtundu Salmonella *mitundu yamtundu Shigella *, Vibrio cholerae, Yersinia enterocolitica *,

- gram-hasan anaerobes - mitundu ya mtundu Mabakiteriya * (kuphatikiza Bacteroides fragilis), mitundu yamitundu Fusobacterium *,

- zina - Borrelia burgdorferi, Chlamydia spp., Leptospira icterohaemorrhagiae, Treponema pallidum.

* Zina mwa mabakiteriya amtunduwu zimatulutsa beta-lactamases, zomwe zimapangitsa kuti azikhala osasangalala ndi amoxicillin monotherapy.

** Tizilombo tambiri ta mabakiteriya amenewa sitingaphatikizidwe ndi amoxicillin / clavulanic acid mu vitro , komabe, kuthandizira kwachipatala kwa kuphatikiza kumeneku kwawonetsedwa mu chithandizo cha matenda amkodzo amtunduwu omwe amayamba chifukwa cha zovuta izi.

Zizindikiro Amoxiclav ®

Mitundu yonse yamiyeso

Matenda oyambitsidwa ndi tizilombo tating'onoting'ono tating'ono:

chapamwamba kupuma thirakiti ndi ENT ziwalo (kuphatikizapo pachimake ndi matenda sinusitis, pachimake ndi matenda otitis TV, pharyngeal abscess, tonsillitis, pharyngitis),

m'munsi kupuma thirakiti (kuphatikizapo pachimake bronchitis ndi bakiteriya wamphamvu, chifuwa, chibayo),

kwamikodzo (mwachitsanzo, cystitis, urethritis, pyelonephritis),

khungu ndi minofu yofewa, kuphatikiza kulumidwa kwa anthu ndi nyama,

mafupa komanso minyewa yolumikizana

bile ducts (cholecystitis, cholangitis),

Wofera pakukonzekera njira yothetsera utsogoleri wa iv

matenda am'mimba

matenda opatsirana pogonana (chinzonono, chancre),

kupewa matenda pambuyo pa opaleshoni.

Contraindication

Hypersensitivity pamagawo a mankhwala,

Hypersensitivity kwa penicillin, cephalosporins ndi mankhwala ena a beta-lactam mu anamnesis,

mbiri yokhala ndi cholestatic jaundice komanso / kapena kukanika kwina kwa chiwindi komwe kumachitika chifukwa cha kuperekedwa kwa amoxicillin / clavulanic acid,

matenda mononucleosis ndi lymphocytic leukemia,

Pamapiritsi omwera Amoxiclav ® Quicktab kuwonjezera

ana osakwana zaka 12 kapena masekeli osakwana 40.

Kulephera kwaimpso (Cl creatinine, m'mimba, kuperewera kwa chiwindi, kukanika kwa impso, kutenga pakati, kuyamwa, kugwiritsidwa ntchito munthawi yomweyo ndi anticoagulants.

Mimba komanso kuyamwa

Pa nthawi yobereka komanso mkaka wa m'mawere, Amoxiclav ® imagwiritsidwa ntchito pokhapokha ngati phindu lomwe likuyembekezeredwa kuti lipite kwa mayi limaposa chiwopsezo cha mwana wosabadwayo ndi mwana.

Amoxiclav ® Quicktab imatha kulembedwera panthawi yapakati ngati pali mawonekedwe omveka.

Amoxicillin ndi clavulanic acid ochepa omwe amalowa mkaka wa m'mawere.

Zotsatira zoyipa

Mapiritsi okhala ndi mafilimu a Amoxiclav ® ndi ufa wokonzekera yankho la iv

Kuchokera m'mimba: kusowa chilimbikitso, kusanza, kusanza, kutsegula m'mimba, kupweteka kwam'mimba, gastritis, stomatitis, glossitis, lilime "lakuda", kuyimitsidwa kwa mano enamel, hemorrhagic colitis (ingathenso kuyamba pambuyo pa mankhwala), enterocolitis, pseudomembranous colitis, kuwonongeka kwa chiwindi, ntchito ALT, AST, zamchere phosphatase ndi / kapena plasma bilirubin, kulephera kwa chiwindi (pafupipafupi kwa okalamba, amuna, omwe ali ndi chithandizo chambiri), cholestatic jaundice, hepatitis.

Zotsatira zoyipa: pruritus, urticaria, erythematous totupa, erythema multiforme exudative, angioedema, anaphylactic mantha, matupi a vasculitis, exfoliative dermatitis, Stevens-Johnson syndrome, pachimake chachikulu pantulosis, matenda ofanana ndi seramu matenda, poizoni epermus.

Kuchokera ku hemopoietic dongosolo ndi dongosolo la lymphatic: leukopenia yosinthika (kuphatikizapo neutropenia), thrombocytopenia, hemolytic anemia, kuchuluka kosintha kwa PV (akagwiritsidwa ntchito limodzi ndi anticoagulants), kuchuluka kosintha kwa nthawi yotaya magazi, eosinophilia, pancytopenia, thrombocytosis, agranulocytosis.

Kuchokera kumbali yamanjenje yapakati: chizungulire, kupweteka mutu, kukomoka (kumachitika mwa odwala omwe ali ndi vuto laimpso akamamwa kwambiri.

Kuchokera pamifupa ya kwamikodzo: interstitial nephritis, crystalluria, hematuria.

Zina: candidiasis ndi mitundu ina yamphamvu kwambiri.

Mapiritsi okhala ndi filimu, ufa wotseka pakamwa, ufa wowonjezera pakamwa kuwonjezera

Kuchokera kumbali yamanjenje yapakati: Hyperacaction. Kumva nkhawa, kusowa tulo, kusintha kwa machitidwe, kukondwerera.

Amoxiclav ® Quicktab ndi Amoxiclav ® ufa kuyimitsidwa pakamwa

Kuchokera ku ziwalo za hemopoietic ndi dongosolo la lymphatic: osowa - leukopenia yosinthika (kuphatikizapo neutropenia), thrombocytopenia, kawirikawiri - eosinophilia, thrombocytosis, agranulocytosis, kuchuluka kwa magazi ndi kuchuluka kwa PV, kuchepa magazi, kuphatikiza magazi kusinthanso hemolytic magazi m'thupi.

Kuchokera ku chitetezo chamthupi: pafupipafupi sizikudziwika - angioedema, anaphylactic zimachitika, matupi awo saviyo, ndi matenda ofanana ndi seramu.

Kuchokera ku dongosolo lamanjenje: pafupipafupi - chizungulire, kupweteka mutu, kawirikawiri - kusowa tulo, kusokonezeka, nkhawa, kusintha kwa machitidwe, kusinthika kwa mankhwalawa, kupweteka, kupweteka kumachitika mwa odwala omwe ali ndi vuto laimpso, komanso kwa omwe amalandira kuchuluka kwa mankhwalawa.

Kuchokera m'mimba: Nthawi zambiri - kusowa kwa chakudya, nseru, kusanza, kutsekula m'mimba. Khansa ya msana imawonedwa kwambiri tikamamwa mitundu yayikulu. Ngati matenda am'mimba atatsimikiziridwa, amatha kutha ngati mankhwalawo atengedwa kumayambiriro kwa chakudya, osachepera - kugaya chakudya, zomwe zimapangitsa kuti antigenicitis ayambidwe ndi maantibayotiki (kuphatikizapo pseudomembranous ndi hemorrhagic colitis), lilime lakuda, gastritis stomatitis. Mu ana, kusintha kwa mawonekedwe a mawonekedwe a mano enamel sikunachitike kawirikawiri. Kusamalira pakamwa kumathandiza kupewa kubowola kwa enamel ya dzino.

Pa khungu: pafupipafupi - zotupa pakhungu, kuyabwa, urticaria, kawirikawiri - kuchuluka kwa erythema kosadziwika, kusadziwika kwapafupipafupi - Stevens-Johnson syndrome, poermal necrolysis yoopsa, dermatitis yodwala kwambiri, pachimake pantulosis yayikulu.

Kuchokera pamifupa ya kwamikodzo: kawirikawiri - crystalluria, interstitial nephritis, hematuria.

Pa mbali ya chiwindi ndi biliary thirakiti: pafupipafupi - ntchito yowonjezereka ya ALT ndi / kapena AST (chodabwitsa ichi chimawonedwa mwa odwala omwe amalandira beta-lactam antiotic therapy, koma tanthauzo lake lamankhwala silikudziwika), Zochitika zolakwika kuchokera ku chiwindi zimawonedwa makamaka mwa abambo ndi odwala okalamba ndipo akhoza kuyanjanitsidwa ndi chithandizo cha nthawi yayitali. Zochitika zoyipa izi sizimawonedwa kawirikawiri mwa ana.

Zizindikiro zomwe zalembedwazo zimakonda kuchitika pakumala kapena atangomaliza kumene chithandizo, komabe nthawi zina mwina sangawonekere kwa milungu ingapo atamaliza kulandira chithandizo. Zochitika zoyipa nthawi zambiri zimasinthidwa. Zochitika zoyipa za chiwindi zimatha kukhala zowopsa, nthawi zina pamakhala nkhani zakufa. Pafupifupi nthawi zonse, awa anali odwala omwe ali ndi vuto lalikulu la matenda kapena odwala omwe amalandila mankhwala oopsa a hepatotoxic. Nthawi zambiri - kuchuluka kwa zamchere phosphatase, kuchuluka bilirubin, hepatitis, cholestatic jaundice (anati ndi concomitant mankhwala ndi penicillin ena ndi cephalosporins).

Zina: Nthawi zambiri - candidiasis a pakhungu ndi mucous nembanemba, pafupipafupi sizikudziwika - Kukula kwa tizilombo tating'onoting'ono.

Kuchita

Mitundu yonse yamiyeso

Maantacid, glucosamine, mankhwala othandizira, aminoglycosides amachepetsa kuyamwa, ascorbic acid imawonjezera kuyamwa.

Ma diuretics, allopurinol, phenylbutazone, NSAIDs ndi mankhwala ena omwe amatsekera katulutsidwe ka cellular (probenecid) amathandizira kuchuluka kwa amoxicillin (clavulanic acid amachotseredwa makamaka ndi kusefera kwa glomerular).

Kugwiritsa ntchito pamodzi kwa Amoxiclav ® ndi methotrexate kumawonjezera kuwopsa kwa methotrexate.

Kukhazikitsidwa pamodzi ndi allopurinol kumawonjezera zochitika za exanthema. Ntchito zofananira ndi disulfiram ziyenera kupewedwa.

Amachepetsa mphamvu ya mankhwala, munthawi ya kagayidwe kamene PABA imapangidwa, ethinyl estradiol - chiopsezo chotaya magazi kwambiri.

Mabukuwa amafotokoza milandu yachilendo ya INR mwa odwala omwe amaphatikizana ndi acenocumarol kapena warfarin ndi amoxicillin. Ngati ndi kotheka, kugwiritsa ntchito nthawi yomweyo ndi anticoagulants PV kapena INR iyenera kuyang'aniridwa mosamala popereka mankhwala kapena kusiya ntchito.

Kuphatikiza ndi rifampicin ndikutsutsana (kufooka kwa mphamvu ya antibacterial). Amoxiclav ® sayenera kugwiritsidwa ntchito nthawi yomweyo kuphatikiza ma bacteriostatic antibayotiki (macrolides, tetracyclines), sulfonamides chifukwa kuchepa kwa mphamvu ya Amoxiclav ®.

Amoxiclav ® imachepetsa mphamvu ya njira zakulera zamkamwa.

Mapiritsi omwera ndi ufa wowayimitsa pakumwa pamlomo

Zimawonjezera kugwira ntchito kwa anticoagulants osalunjika (kupondereza microflora yamatumbo, kumachepetsa kapangidwe ka vitamini K ndi index ya prothrombin). Nthawi zina, kumwa mankhwalawa kungakulitse PV, motere, chisamaliro chiyenera kutengedwa ndikugwiritsa ntchito anticoagulants ndi mankhwala Amoxiclav ® Quicktab.

Probenecid amachepetsa kuwonongeka kwa amoxicillin, kukulitsa kuchuluka kwake kwa seramu.

Odwala omwe amalandila mycophenolate mofetil, atayamba kugwiritsa ntchito mankhwala osakanikirana a amoxicillin ndi clavulanic acid, kuchepa kwa ndende yogwira metabolic, mycophenolic acid, adawonedwa asanamwe mlingo wotsatira wa mankhwalawa pafupifupi 50%. Zosintha pamawonekedwe awa sizingawonetse moyenera kusintha kwamtundu wa mycophenolic acid.

Wofera pakukonzekera njira yothetsera utsogoleri wa iv

Mankhwala a Amoxiclav ® ndi aminoglycoside ndiosagwirizana.

Osasakanikirana ndi Amoxiclav ® mu syringe kapena kulowetsedwa vial ndi mankhwala ena.

Pewani kusakanikirana ndi mayankho a dextrose, dextran, sodium bicarbonate, komanso ndi mayankho okhala ndi magazi, mapuloteni, lipids.

Mlingo ndi makonzedwe

Mapiritsi okhala ndi mafilimu

Mkati. Mlingo wa mankhwalawa umayikidwa payekhapayekha, kutengera zaka, kulemera kwa thupi, impso ya wodwalayo, komanso kuopsa kwa matendawa.

Amoxiclav ® ndikulimbikitsidwa kuti idatengedwe kumayambiriro kwa chakudya kuti mayamwidwe bwino komanso kuti muchepetse zotsatirapo zoyipa zamagetsi.

Njira ya mankhwala ndi masiku 5-14. Kutalika kwa nthawi ya chithandizo akutsimikiza ndi dokotala. Kuchiza sikuyenera kupitirira masiku opitilira 14 popanda kupimidwa kachiwiri.

Mlingowo umaperekedwa potengera zaka komanso kulemera kwa thupi. Mlingo woyenera ndi 40 mg / kg / tsiku mu 3 mgawani.

Ana omwe ali ndi thupi lolemera 40 makilogalamu kapena kupitilira ayenera kupatsidwa mlingo wofanana ndi akulu. Kwa ana azaka zapakati pa ≤6, ndikofunikira kwambiri kuyimitsidwa kwa Amoxiclav ®.

Akuluakulu ndi ana opitilira zaka zopitilira 12 (kapena> 40 makilogalamu akulemera thupi)

Mlingo wamba pofatsa pakamwa pang'ono piritsi limodzi. 250 + 125 mg maola 8 aliwonse kapena piritsi limodzi. 500 + 125 mg maola 12 aliwonse, ngati pali matenda opatsirana kwambiri komanso matenda opatsirana a m'mapapo - 1 tebulo. 500 + 125 mg maola 8 aliwonse kapena piritsi limodzi. 875 + 125 mg maola 12 aliwonse

Popeza mapiritsi osakanikirana a amoxicillin ndi clavulanic acid 250 + 125 mg ndi 500 + 125 mg aliyense amakhala ndi kuchuluka kwa clavulanic acid - 125 mg, ndiye mapiritsi awiri. 250 + 125 mg sizofanana ndi piritsi limodzi. 500 + 125 mg.

Mlingo wa matenda odontogenic

1 tabu. 250 + 125 mg maola 8 aliwonse kapena piritsi limodzi. 500 + 125 mg maola 12 aliwonse kwa masiku 5.

Odwala ndi mkhutu aimpso ntchito

Kusintha kwa Mlingo wokhazikika pazotsatira zoyenera za amoxicillin ndipo zimachitika poganizira mfundo za Cl designinine:

- achikulire ndi ana azaka zopitilira 12 (kapena ≥40 makilogalamu a kulemera kwa thupi) (tebulo. 2),

- ndi anuria, gawo pakati pa dosing liyenera kuchuluka mpaka maola 48 kapena kupitirira,

- Mapiritsi a 875 + 125 mg ayenera kugwiritsidwa ntchito mwa odwala a Cl creatinine> 30 ml / min.

Mphamvu yakuyimitsidwa pakamwa

Mlingo watsiku ndi tsiku wa kuyimitsidwa ndi 125 + 31.25 mg / 5 ml ndi 250 + 62,5 mg / 5 ml (kutsogolera dosing yoyenera, mu phukusi lililonse la kuyimitsidwa 125 + 31.25 mg / 5 ml ndi 250 + 62,5 mg / 5 ml, piritsi yomaliza maphunziro 5 ml yokhala ndi 0,5 ml kapena supuni ya 5 ml, imayikidwa. zikwangwani zakale za 2,5 ndi 5 ml).

Makanda obadwa kumene ndi ana mpaka miyezi itatu - 30 mg / kg / tsiku (malinga ndi amoxicillin), logawidwa mu 2 waukulu (maola 12 aliwonse).

Mlingo wa mankhwala Amoxiclav ® ndi dosing pipette - kuwerengetsa Mlingo umodzi zochizira matenda kwa akhanda ndi ana mpaka miyezi 3 (Table 3).

Ana okulirapo kuposa miyezi itatu - kuchokera 20 mg / kg chifukwa cha matenda ofatsa kwambiri mpaka 40 mg / kg pa matenda opatsirana kwambiri komanso kupumira kwamatumbo opatsirana, ma atitis media, sinusitis (amoxicillin) patsiku, omwe amagawidwa katatu.

Mlingo wa mankhwala Amoxiclav ® ndi dosing pipette - kuwerengetsa kwa Mlingo umodzi wowerengeka wa ana opitilira miyezi itatu (kutengera 20 mg / kg / tsiku (la amoxicillin) (Table 4).

Mlingo wa mankhwala Amoxiclav ® ndi dosing pipette - kuwerengedwa kwa Mlingo umodzi wowerengeka wowerengeka wa ana opitirira miyezi itatu (kutengera 40 mg / kg / tsiku (la amoxicillin) (Table 5).

Mlingo wa mankhwala Amoxiclav ® ndi supuni ya kumwa (pakalibe mlingo wa piritsi) - mlingo woyenera wa kuyimitsidwa kutengera thupi la mwana komanso kuopsa kwa matendawa.

Tsiku lililonse kuyimitsidwa 400 mg + 57 mg / 5 ml

Mlingo amawerengedwa pa kilogalamu iliyonse yakulemera kwa thupi, kutengera kuopsa kwa matendawa. Kuchokera pa 25 mg / kg pa matenda ofatsa kwambiri mpaka 45 mg / kg pa matenda opatsirana kwambiri komanso kupepuka kwa matenda opatsirana, otitis media, sinusitis (malinga ndi amoxicillin) patsiku, logawidwa mu 2 waukulu.

Kuwongolera dosing yoyenera, kuyimitsidwa kwa 400 mg + 57 mg / 5 ml ndikuyikidwa mu phukusi lirilonse la pipette ya mlingo, omaliza nthawi imodzi mu 1, 2, 3, 4, 5 ml ndi magawo 4 ofanana.

Kuyimitsidwa kwa 400 mg + 57 mg / 5 ml amagwiritsidwa ntchito mwa ana okulirapo kuposa miyezi itatu.

Mlingo woyenera wa kuyimitsidwa kutengera thupi la mwana komanso kuopsa kwa matendawa

Mlingo wofanana watsiku ndi tsiku amawerengedwa potengera thupi la mwana, osati zaka zake.

Mlingo wapamwamba wa tsiku lililonse wa amoxicillin ndi 6 ga kwa akulu ndi 45 mg / kg kwa ana.

Mlingo wapamwamba wa tsiku ndi tsiku wa clavulanic acid (munthawi ya mchere wa potaziyamu) ndi 600 mg kwa akulu ndi 10 mg / kg kwa ana.

Odwala ndi mkhutu aimpso ntchito, mlingo uyenera kusintha malinga ndi pazipita mlingo wa amoxicillin.

Odwala omwe ali ndi creatinine Cl> 30 ml / min safuna kusintha kwa mtundu uliwonse.

Akuluakulu ndi ana olemera oposa 40 kg (njira yeniyeniyo ya mankhwalawa imagwiritsidwa ntchito pochotsa matenda osakwanira komanso koopsa)

Odwala a Cl creatinine 10-30 ml / mphindi - 500/125 mg 2 kawiri pa tsiku.

Cl Clininine Cl creatinine 10-30 ml / mphindi, mlingo woyenera ndi 15 / 3.75 mg / kg kawiri pa tsiku (pazambiri 500/125 mg 2 kawiri pa tsiku).

Ndi Cl creatinine iv

Ana: ndi kulemera kwa thupi zosakwana 40 makilogalamu - mlingo amawerengedwa kutengera kulemera kwa thupi.

Osakwana miyezi 3 yokhala ndi kulemera kwa thupi zosakwana 4 kg - 30 mg / kg (malinga ndi mankhwala onse a Amoxiclav ®) maola 12 aliwonse

Pansi pa miyezi itatu ndi thupi lolemera kuposa 4 kg - 30 mg / kg (malinga ndi mankhwala onse a Amoxiclav ®) maola 8 aliwonse

Mwa ana ochepera miyezi 3, Amoxiclav ® imayenera kuperekedwa pang'onopang'ono kwa mphindi 30-40.

Ana kuyambira miyezi itatu mpaka zaka 12 - 30 mg / kg (malinga ndi kukonzekera kwathunthu Amoxiclav ®) ndi nthawi yotalikirapo maola 8, ngati matendawa atenga matenda ambiri - pakadutsa maola 6

Ana omwe ali ndi vuto laimpso

Kusintha kwa Mlingo wokhazikika pazotsatira zoyenera za amoxicillin. Kwa odwala omwe ali ndi Cl creatinine pamtunda wa 30 ml / min, kusintha kwa mlingo sikofunikira.

Ana olemera Cl creatinine 10-30 ml / min25 mg / 5 mg pa 1 kg maola 12 aliwonse Cl creatinine ® imakhala ndi 25 mg ya amoxicillin ndi 5 mg ya clavulanic acid.

Akuluakulu ndi ana opitirira zaka 12 kapena osaposa 40 makilogalamu - 1,2 g ya mankhwalawa (1000 + 200 mg) ndi nthawi yotalikirapo maora 8, ngati ali ndi vuto lalikulu - -

Mlingo wowonjezera wothandiza pakuchitidwa opaleshoni: 1.2 g ndi mankhwala opaleshoni (ndi nthawi ya opaleshoni yochepera maola 2). Kwa ntchito yayitali - 1.2 ga mpaka 4 pa tsiku.

Kwa odwala omwe ali ndi vuto la aimpso, muyezo komanso / kapena pakati pa jakisoni wa mankhwalawa amayenera kusintha malinga ndi kuchuluka kwa kusakwanira:

Popeza 85% ya mankhwalawa imachotsedwa ndi hemodialysis, kumapeto kwa njira iliyonse ya hemodialysis, muyenera kulowa muyezo wa Amoxiclav ®. Ndi peritoneal dialysis, kusintha kwa mankhwala sikofunikira.

Njira ya mankhwala ndi masiku 5-14. Kutalika kwa nthawi ya chithandizo akutsimikiza ndi dokotala. Ndi kuchepa kwa kuopsa kwa zizindikilo, kusintha kwa mitundu yamkamwa ya Amoxiclav ® ndikulimbikitsidwa kuti mupitilize mankhwala.

Kukonzekera kwa mayankho a jakisoni wa iv. Sungunulani zomwe zili mu vial m'madzi a jakisoni: 600 mg (500 + 100 mg) mu 10 ml ya madzi a jakisoni kapena 1.2 g (1000 + 200 mg) mu 20 ml ya madzi a jekeseni. Mu / kulowa kulowa pang'onopang'ono (mkati mwa mphindi 3-4).

Amoxiclav ® iyenera kuperekedwa pakadutsa mphindi 20 pambuyo pokonzekera njira zoyendetsera iv.

Kukonzekera njira zothetsera kulowetsedwa kwa iv. Pa kulowetsedwa kwa Amoxiclav ®, kuchepetsedwa kowonjezereka ndikofunikira: mayankho okonzekera omwe ali ndi 600 mg (500 + 100 mg) kapena 1.2 g (1000 + 200 mg) ya mankhwalawa amayenera kuchepetsedwa mu 50 kapena 100 ml ya kulowetsedwa. Kutalika kwa kulowetsedwa ndi mphindi 30 mpaka 40.

Mukamagwiritsa ntchito zakumwa zotsatirazi pamavuto obwera, maantibayotiki ofunikira amasungidwa:

Njira yothetsera mankhwalawa Amoxiclav ® siyingasakanikirane ndi mayankho a dextrose, dextran kapena sodium bicarbonate.

Mayankho omveka okha ndi omwe ayenera kugwiritsidwa ntchito. Njira zakonzedwa siziyenera kuzizira.

Mkati. Mlingo wa mankhwalawa umayikidwa payekha kutengera zaka, kulemera kwa thupi, ntchito ya impso ya wodwalayo komanso kuopsa kwa matendawa.

Mapiritsiwo ayenera kusungunuka theka la kapu ya madzi (osachepera 30 ml) ndikusakanizidwa bwino, kenako imwani kapena gwiritsani ntchito mapiritsiwo mkamwa mpaka atasungunuka kwathunthu, kenako ndikumeza.

Pofuna kuchepetsa chiwopsezo cha mavuto obwera chifukwa cha m'mimba, mankhwalawa amayenera kumwedwa kumayambiriro kwa chakudya.

Amoxiclav ® Quicktab Mapiritsi Osiyanasiyana 500 mg / 125 mg:

Akuluakulu ndi ana azaka zopitilira 12 okhala ndi thupi lolemera ≥40 kg

Zochizira matenda ofatsa pang'ono zolimbitsa - 1 tebulo. (500 mg / 125 mg) maola 12 aliwonse (kawiri pa tsiku).

Zochizira matenda opatsirana ndi matenda a kupuma dongosolo - 1 tebulo. (500 mg / 125 mg) maola 8 aliwonse (katatu pa tsiku).

Mlingo wapamwamba wa tsiku ndi tsiku wa Amoxiclav ® Quicktab ndi 1,500 mg ya amoxicillin / 375 mg wa clavulanic acid.

Odwala ndi mkhutu aimpso ntchito. Odwala omwe ali ndi creatinine Cl pamwamba pa 30 ml / mphindi, kusintha kwa mlingo sikofunikira.

Akulu ndi ana a zaka zopitilira 12 okhala ndi thupi lolemera ≥40 kg (njira ya dosing yomwe akuwonetsedwa imagwiritsidwa ntchito pochotsa matenda osakhazikika komanso koopsa):

Akuluakulu ndi ana azaka zopitilira 12 okhala ndi thupi lolemera ≥40 kg

Woopsa matenda ndi kupuma matenda - 1 gome. (875 mg / 125 mg) maola 12 aliwonse (kawiri pa tsiku).

Mlingo wa tsiku ndi tsiku wa mankhwala Amoxiclav ® Quicktab akagwiritsidwa ntchito kawiri pa tsiku ndi 1750 mg ya amoxicillin / 250 mg ya clavulanic acid.

Odwala ndi mkhutu aimpso ntchito. Odwala omwe ali ndi Cl creatinine woposa 30 ml / mphindi, palibe chifukwa chofuna kusintha kwa mlingo.

Kwa odwala omwe ali ndi Cl creatinine osakwana 30 ml / min, kugwiritsa ntchito mapiritsi omwedwa a Amoxiclav ® Quicktab, 875 mg / 125 mg ndi kutsutsana.

Odwala otere amayenera kumwa mankhwalawa pa mlingo wa 500 mg / 125 mg pambuyo pa kusintha kwa mlingo woyenera wa creatinine Cl.

Odwala omwe ali ndi vuto la chiwindi. Mukamamwa Amoxiclav ® Quicktab, muyenera kusamala. Kuwunikira pafupipafupi kwa ntchito ya chiwindi ndikofunikira. Ngati chithandizo chikuyambitsidwa ndi makulidwe a makolo ake, ndizotheka kupitiliza mankhwalawa ndi mapiritsi a Amoxiclav ® Quicktab.

Kutalika kwa nthawi ya chithandizo akutsimikiza ndi dokotala!

Njira yochepetsetsa ya mankhwala opha maantibayotiki ndi masiku 5. Kuchiza sikuyenera kupitilira masiku opitilira 14 osanenapo za matenda.

Bongo

Palibe malipoti a imfa kapena zovuta zoyipa chifukwa cha mankhwala osokoneza bongo.

Zizindikiro Nthawi zambiri, kusokonezeka kwa m'mimba thirakiti (kupweteka kwam'mimba, kutsegula m'mimba, kusanza), kuda nkhawa, kusowa tulo, chizungulire ndizothekanso, ndipo nthawi zina kumugwira ndikumugwira.

Chithandizo: vuto la bongo, wodwalayo ayenera kuyang'aniridwa ndi dokotala, chithandizo ndi chisonyezo.

Pankhani yoyendetsa posachedwa (osakwana maola 4) a mankhwalawa, ndikofunikira kutsuka m'mimba ndikuwapatsa makala ophatikizidwa kuti muchepetse mayamwidwe. Amoxicillin / potaziyamu clavulanate amachotsedwa ndi hemodialysis.

Malangizo apadera

Mitundu yonse yamiyeso

Ndi njira ya chithandizo, ndikofunikira kuwunika momwe ntchito ya magazi, chiwindi, ndi impso.

Odwala omwe ali ndi vuto la impso, kusinthitsa kwa mlingo wokwanira kapena kuwonjezeka kwa zinthu pakati pa Mlingo wofunikira.

Ndikotheka kukhala ndi superinitness chifukwa cha kukula kwa microflora sazindikira izi, zomwe zimafunikira kusintha kofananirana ndi mankhwala opha maantibayotiki.

Odwala omwe ali ndi hypersensitivity ku penicillin, zovuta zomwe zimachitika ndi mankhwala a cephalosporin zimatheka.

Mwa akazi omwe ali ndi matendawa zisanachitike, anapezeka kuti mankhwala a prophylactic omwe ali ndi amoxicillin + clavulanic acid akhoza kuphatikizidwa ndi chiopsezo chowonjezeka cha necrotizing colitis ku akhanda.

Odwala omwe ali ndi kuchepetsedwa kwa diuresis, crystalluria ndiyosowa kwambiri. Pogwiritsa ntchito milingo yayikulu ya amoxicillin, tikulimbikitsidwa kuti timwe madzi okwanira ndikukhalanso ndi diursis yokwanira kuti muchepetse mawonekedwe a mapangidwe a amoxicillin.

Zoyeserera zasayansi. Kuyika mozama kwa amoxicillin kumapereka mayankho olakwika a mkodzo pogwiritsa ntchito njira ya Benedict kapena reelling. Enzymatic zimachitikira ndi glucosidase tikulimbikitsidwa.

Mapiritsi omwera ndi ufa wowayimitsa pakumwa pamlomo

Musanayambe chithandizo, ndikofunikira kufunsa wodwalayo kuti adziwe mbiri ya kusintha kwa hypersensitivity kwa penicillin, cephalosporins, kapena mankhwala ena a beta-lactam.

Pofuna kuchepetsa chiwopsezo cha mavuto obwera kuchokera m'matumbo am'mimba, mankhwalawa amayenera kumwedwa musanadye kapena panthawi ya chakudya.

Mukamagwiritsa ntchito mlingo waukulu wa Amoxiclav ® Quiktab, odwala omwe ali ndi makristali amafunika kubwezeretsa mokwanira madzi am'madzi.

Ngati colitis yokhudzana ndi maantibayotiki ipezeka, musiyeni nthawi yomweyo Amoxiclav ® Quicktab, funsani dokotala ndikuyamba chithandizo choyenera. Mankhwala omwe amalepheretsa peristalsis amaphatikizidwa motere.

Kuchiza kumapitirirabe kwa maola 48-72 atatha kutha kwa matenda a matenda. Pogwiritsa ntchito nthawi imodzimodziyo mankhwala okhala ndi pakamwa okhala ndi estrogen komanso amoxicillin, njira zina kapena zowonjezera zakulera ziyenera kugwiritsidwa ntchito ngati kuli kotheka.

Amoxicillin ndi clavulanic acid angapangitse kusakanikirana kwa ma immunoglobulins ndi albumin kumimba ya erythrocyte, yomwe imatha kukhala chifukwa champhamvu chotsatira ndi mayeso a Coombs.

Kugwiritsa ntchito amoxicillin ndi clavulanic acid kumakhudzana ndi matenda mononucleosis, chifukwa kumatha kupangitsa kuti pakhungu lizimveka.

Njira zopewera kusamala pothana ndi mankhwala osagwiritsidwa ntchito. Palibe chifukwa chofunikira kusamalitsa mwapadera mukataya Amoxiclav ® yosagwiritsidwa ntchito.

Kukopa pa kuyendetsa galimoto kapena kugwira ntchito yomwe imafunikira kuthamanga kwamphamvu kwamthupi ndi m'maganizo. Chifukwa chakukula kwakubwera pakati pa dongosolo lamanjenje lamkati, monga chizungulire, kupweteka mutu, ndi kukhudzika, chisamaliro chikuyenera kugwiritsidwa ntchito mukamayendetsa galimoto ndi zochitika zina zofunikira zomwe zimayambitsa chidwi komanso kuthamanga kwa zochitika zama psychomotor.

Kwa mapiritsi okhala ndi filimu, mapiritsi omwazika, ufa woyimitsidwa pakamwa, kuwonjezera apo

Pofuna kuchepetsa chiwopsezo cha mavuto obwera kuchokera m'matumbo am'mimba, mankhwalawa amayenera kumwa ndi zakudya.

Wofera pakukonzekera njira yothetsera utsogoleri wa iv

Amoxicillin ndi clavulanic acid angapangitse kumanga kwa immunoglobulins ndi albumin ku membala wa erythrocyte, komwe kungakhale chifukwa choyesa chabodza cha Coombs.

Zambiri kwa odwala omwe ali ndi chakudya chochepa cha sodium: iliyonse ya 600 mg vial (500 + 100 mg) imakhala ndi 29.7 mg wa sodium. Vial iliyonse ya 1.2 g (1000 + 200 mg) imakhala ndi 59.3 mg wa sodium. Kuchuluka kwa sodium pazokwanira tsiku lililonse kuposa 200 mg.

Kutulutsa Fomu

Mapiritsi okhala ndi mafilimu, 250 mg + 125 mg. 15, 20 kapena 21 mapiritsi. ndi ma desiccants awiri (silika gel osakaniza) mumtundu wofiirira wofiyira wokhala ndi mawu oti "chosakhazikika" mu botolo lagalasi lakuda lomwe lili ndi chingwe cholimba chachitsulo ndi mphete yolamulira yodzikongoletsera komanso gasket ya LDPE mkati. 1 fl. pa kakhadi kadi.

Mapiritsi okhala ndi mafilimu, 500 mg + 125 mg. 15 kapena 21 mapiritsi. ndi ma desiccants awiri (silika gel osakaniza) mumtundu wofiirira wofiyira wokhala ndi mawu oti "osakhazikika" mu botolo lagalasi lakuda lomwe lili ndi chingwe cholimba chachitsulo ndi mphete yolamulira yodzikongoletsera komanso gasket ya LDPE mkati. 1 fl. pa kakhadi kadi.

Mapiritsi a 5 kapena 7. mu chithuza chamtundu wa aluminium wolimba / wofewa wa aluminiyamu. 2, 3 kapena 4 matuza a mapiritsi 5. kapena matuza awiri a mapiritsi 7. pa kakhadi kadi.

Mapiritsi okhala ndi mafilimu, 875 mg + 125 mg. Mapiritsi a 5 kapena 7. mu chithuza chamtundu wa aluminium wolimba / wofewa wa aluminiyamu. 2 kapena 4 matuza a mapiritsi 5. kapena matuza awiri a mapiritsi 7. pa kakhadi kadi.

Ufa woyimitsidwa pakamwa, 125 mg + 31.25 mg / 5 ml kapena 250 mg + 62,5 mg / 5 ml. Kukhazikitsidwa kwapakatikati - 25 g ufa (100 ml ya kuyimitsidwa kotsirizika) mugalasi lamdima lamdima ndi chilembo (100 ml). Botolo limatsekedwa ndi sikelo yachitsulo ndi mphete yowongolera, mkati mwa kapu pali gasket yopangidwa ndi LDPE.

Ma CD a sekondale - 1 fl. ndi supuni ya mulingo wokhala ndi zikwangwani zozungulira mu 2,5 ndi 5 ml ("2.5 SS" ndi "5 SS"), chizindikiro cha kudzaza kwakukulu kwa 6 ml ("6 SS") pa chogwiririra cha supuni m'bokosi lamatoni. Kapena 1 fl. pamodzi ndi pipette yomaliza maphunziro pamakadi a kakhadi.

Ufa woyimitsidwa pakamwa, 400 mg + 57 mg / 5 ml. Katemera woyambirira - 8.75 g (35 ml ya kuyimitsidwa kotsiriza), 12,50 g (50 ml ya kuyimitsidwa kotsilizidwa), 17.50 g (70 ml ya kuyimitsidwa kotsiriza) kapena 35.0 g (140 ml ya kuyimitsidwa kotsiriza) wa ufa pang'ono. galasi yakuda yokhala ndi chivundikiro chowoneka chopangidwa ndi HDPE chokhala ndi mphete yowongolera komanso chomata mkatikati.Kapena 17.5 g (70 ml ya kuyimitsidwa kotsirizika) mugalasi lamdima wamdima wokhala ndi cholozera (70 ml) ndi chivundikiro chowoneka chopangidwa ndi HDPE chokhala ndi mphete yolamulira komanso ndi gasket mkati mwa chivindikiro.

Ma CD a sekondale - 1 fl. pamodzi ndi pipette yomaliza maphunziro pamakadi a kakhadi.

Ufa wa yankho la kulowetsedwa kwamtsempha, 500 mg + 100 mg kapena 1000 mg + 200 mg. 500 mg ya amoxicillin ndi 100 mg ya clavulanic acid kapena 1000 mg ya amoxicillin ndi 200 mg ya clavulanic acid mu botolo lagalasi lopanda utoto, lotsekeka ndi chopukutira ndi chopukutira cha aluminium ndi chipewa cha pulasitiki. 5 tsa. anayikidwa mu katoni.

Mapiritsi osokoneza, 500 mg + 125 mg kapena 875 mg + 125 mg. Mapiritsi 2 pachimake. Matuza 5 kapena 7 amaikidwa pakatoni.

Wopanga

Lek dd Verovshkova 57, Ljubljana, Slovenia.

Pa ufa pokonzekera yankho la intravenous makonzedwe

1. Lek dd, Verovshkova 57, Ljubljana, Slovenia.

2. Sandoz GmbH, Biohemistrasse 10 A-6250, Kundl, Austria.

Zodandaula za ogula ziyenera kutumizidwa ku Sandoz CJSC: 125317, Moscow, Presnenskaya nab., 8, p. 1.

Tele. ((495) 660-75-09, fax: (495) 660-75-10.

Amoxiclav ®

mafilimu okhala ndi mafilimu 250 mg + 125 mg 250 mg + 125 - zaka 2.

mafilimu okhala ndi mafilimu 500 mg + 125 mg 500 mg + 125 - zaka 2.

mafilimu okhala ndi mafilimu 875 mg + 125 mg 875 mg + 125 - zaka ziwiri.

ufa pokonzekera yankho la mtsempha wa magazi mtsempha wa 500 mg + 100 mg 500 mg + 100 - 2 zaka.

ufa pokonzekera yankho la mtsempha wa magazi mtsempha wa 1000 mg + 200 mg 1000 mg + 200 - zaka 2.

dispersible mapiritsi 500 mg + 125 mg 500 mg + 125 - zaka 3.

dispersible mapiritsi 875 mg + 125 mg 875 mg + 125 - zaka 3.

ufa w kuyimitsidwa kwa makonzedwe amkamwa a 125 mg + 31.25 mg / 5 ml 125 mg + 31.25 mg / 5 - 2 zaka. Kuyimitsidwa kwamaliza ndi masiku 7.

ufa kuyimitsidwa pakamwa makonzedwe a 250 mg + 62,5 mg / 5 ml 250 mg + 62,5 mg / 5 - 2 zaka. Kuyimitsidwa kwamaliza ndi masiku 7.

ufa woyimitsidwa pakumwa kwamlomo 400 mg + 57 mg / 5 ml 400 mg + 57 mg / 5 - 3 zaka. Kuyimitsidwa kwamaliza ndi masiku 7.

Osagwiritsa ntchito tsiku lotha ntchito likusonyezedwa pa phukusi.

Kuphatikizika ndi mankhwala a Amoxiclav 125 milligrams

Amoxiclav 125 mg ili ndi:

1. Amoxicillin - amatanthauza ma penicillin omwe amatha kusintha ndikuwononga kuchuluka kwachilengedwe ndi mabakiteriya achilendo.
2. Clavulanic acid ndi beta-lactam, yomwe imachepetsa kuwonongeka kwa chinthu chachikulu motero imachulukitsa nthawi ya mankhwala a penicillin.

Fomu yotulutsira ndi kapangidwe kake ka mankhwalawo amalola odwala omwe ali m'malo otetezeka kwambiri kuti athane ndi matendawa osaganizira zovulaza thupi. Akatswiri ambiri amalankhula za mankhwalawa kuti ndi imodzi yosavuta kwa ana ndi akulu kuti aziwerenga.

Malangizo ogwiritsira ntchito ndi mawonekedwe omwe amasulidwe amafotokozera mapiritsi a Amoxiclav ndi kuyimitsidwa kwa Amoxiclav (makamaka, ufa pokonzekera kuyimitsidwa).

Zosangalatsa! Pali amoxiclav quiktab, yomwe imakhalapo, komabe, imagulitsidwa kokha mu mankhwala a 625 mg ndi 1000 mg.

Pogwiritsa ntchito mankhwala enaake, monga 5 ml ya mankhwala = 125 mg ya amoxicillin + 31,5 mg wa clavulanic acid, amathandiza kupirira matenda.

Kufotokozera kwa mankhwalawo kumatsimikizira kuti mankhwalawo amapha magulu osiyanasiyana a mabakiteriya ndi ma tizilombo. Nthawi zambiri amati Amoxiclav 125 ndi ya ana, popeza ali ndimadzi amadzimadzi, omwe amathandizira kugwiritsa ntchito.

Momwe zimaswana

Kuti mudziwe momwe mungatengere kwa ana, ndipo koposa zonse momwe mungagwiritsire ntchito amoxiclav molondola, muyenera kuyang'ana malangizo omwe angagwiritse ntchito:

1. Sansani botolo la ufa kuti mumasulidwe.
2. Onjezani botolo lamadzi oyeretsedwa poyamba pakati pa botolo ndikugwedezeka, kenako onjezerani madzi ena m'botolo, koma mpaka kale pamalowo. Pambuyo pa izi, gwiranani kuyimitsidwa kwa Amoxiclav kachiwiri.

Phatikizani mankhwalawa ndi ma millilitere 86 amadzi, ndipo kuyimitsidwa kotsiriza kwa ana mu mawonekedwe otseguka ndi sabata.

Zosangalatsa! Njira yokonzekera kuyimitsidwa kwa Amoxiclav 125 mg kwa mwana wazaka ziwiri sizikhala zosiyana ndi kuchepetsedwa kwa mankhwalawa kwa mwana wazaka 12 zakubadwa. Ndikofunika kuwerengera mulingo woyenera kuti madziwo athe kugwira.

Zambiri zofunika kutenga

Amoxiclav malinga ndi malangizo ayenera kumwedwa kuchokera masiku 5 mpaka 7, koma monga momwe dokotala wanenera, mutha kumwa mankhwalawa kwa milungu iwiri. Kwa masiku opitilira 14, kumwa Amoxiclav 125 sikudzakhala koyenera, chifukwa chazolowera kugwiritsa ntchito mankhwalawa.

Chinthu chachikulu chomwe muyenera kukumbukira mukamamwa Amoxiclav 125 mg ndikuti ndi masiku angati omwe mungagwiritse ntchito mankhwalawa ayenera kutsimikiziridwa ndi adokotala. Kuphwanya malangizo a adokotala kungayambitse mavuto osaneneka.